LOCUS       NZ_WHZR01000001        21194 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. OM5714 A912_AS4_SC1_R2, whole genome shotgun
            sequence.
ACCESSION   NZ_WHZR01000001
VERSION     NZ_WHZR01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. OM5714
  ORGANISM  Streptomyces sp. OM5714
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M.
  TITLE     Whole Genome Sequence of the phthoxazolin producer Streptomyces sp.
            OM5714
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2019) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2017
            Assembly Method                   :: Newbler v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010993835.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:48:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,730
            Genes (coding)                    :: 7,557
            CDSs (with protein)               :: 7,557
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 7, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 7, 5 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 58 of 173
            Pseudo Genes (incomplete)         :: 139 of 173
            Pseudo Genes (internal stop)      :: 18 of 173
            Pseudo Genes (multiple problems)  :: 36 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:03:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2876354
            Orig. end                         :: 2897548
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHZR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21194
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="19"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21194
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21194
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11194](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11194)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(685..1149)
                     /locus_tag="STPH1_RS12295"
                     /old_locus_tag="STPH1_2457"
     CDS             complement(685..1149)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984616.1"
                     /locus_tag="STPH1_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2457"
                     /product="ATP-binding protein"
                     /protein_id="WP_164383365.1"
                     /transl_table=11
                     /translation="MPINPTKRDTGGGLSAGEVIGVSDDEGDCAEWVFPAAPDAVRTAR
                     SLVRRTLDEWRLGGVADLTALLVSELVTNALRHATGPIGVRLVRDPAGAAGVLLVEVSD
                     PLPDPPRERVARADDEDGRGLQLVASVTRRWGTRPGEAGKTVWFELALPR"
     gene            complement(1177..1611)
                     /locus_tag="STPH1_RS12300"
                     /old_locus_tag="STPH1_2458"
     CDS             complement(1177..1611)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973876.1"
                     /locus_tag="STPH1_RS12300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2458"
                     /product="(deoxy)nucleoside triphosphate
                     pyrophosphohydrolase"
                     /protein_id="WP_164383366.1"
                     /transl_table=11
                     /translation="MTERIVVGAALLDGGRLLAARRSAPAELAGRWELPGGKVEAGETP
                     EAALERELREELGVAAEAGERVPGQWPLRAPFVLQVWTARLLPGSAAPQPLEDHDDLRW
                     LTPAQVWDVPWLEQDVPAVERVLAHLGLGASGAARGTGPG"
     gene            complement(1672..1863)
                     /locus_tag="STPH1_RS12305"
                     /old_locus_tag="STPH1_2459"
     CDS             complement(1672..1863)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973877.1"
                     /locus_tag="STPH1_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2459"
                     /product="SPOR domain-containing protein"
                     /protein_id="WP_007444327.1"
                     /transl_table=11
                     /translation="MNDSTVTLPWLVFRQDDNGNRYRVGRYATRAEAQQIADTLDGRGH
                     QQLYWVERLGAAGTGTAD"
     misc_feature    1977..1990
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.49"
                     /tool="antismash"
     gene            complement(2263..3015)
                     /locus_tag="STPH1_RS12310"
                     /old_locus_tag="STPH1_2460"
     CDS             complement(2263..3015)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998196.1"
                     /locus_tag="STPH1_RS12310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2460"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_153178129.1"
                     /transl_table=11
                     /translation="MTFGEQPAYLRVAGDLRKKIADGLLPPHTRLPSQARIREEYGVSD
                     TVALEARKVLMAEGLVEGRSGSGTYVRERPVPRRVARSGYRPAGGATPFRQEQADADAR
                     GTWESRSEQAEASGAVAERLGIKPGDRVMCTRYVFRESGEAVMLSTSWEPLDLTGRTPV
                     MLPEEGPLGGMGVVERMAAIDVVVDNVTEEVGARPGLAEELLALGGVPGHVVLVVQRTF
                     YASGRAVETADVVVPADRYRVAYHLPVR"
     misc_feature    complement(3028..3046)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.0"
                     /tool="antismash"
     gene            complement(3162..4196)
                     /locus_tag="STPH1_RS12315"
                     /old_locus_tag="STPH1_2461"
     CDS             complement(3162..4196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444325.1"
                     /locus_tag="STPH1_RS12315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2461"
                     /product="DUF4190 domain-containing protein"
                     /protein_id="WP_346429408.1"
                     /transl_table=11
                     /translation="MNGLAVAAFVLGVLCFVPAVGLVLGLIALVRIRKRGERGKGFAVA
                     GCVLSSVGLALWALTLSTGAVADFWEGFRDAARGEGTAYALEKGECFTTPGGSLQGVTY
                     DVDQVPCAAEHDGEVFAVFDLPRGGSYPGDDALTSMADLRCYGLVGEYAMDDWALPADV
                     DVYYLTPTRRSWLSNDREITCLFGSTDERKNLTGSLRNDATTLDAHQIAYLEAARALDG
                     ALESTPENEYFEDDPTAQQAWAGRVENALTEEIGMLGAHSWPSASEQPVSELVTDLEAA
                     REEFAAAEATPDADAFYEHLYQGYALIDGDTTVTARESLGLDTTPPEYAESGGDGGESP
                     GREV"
     gene            complement(4408..4749)
                     /locus_tag="STPH1_RS12320"
                     /old_locus_tag="STPH1_2462"
     CDS             complement(4408..4749)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444324.1"
                     /locus_tag="STPH1_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2462"
                     /product="YrdB family protein"
                     /protein_id="WP_164383368.1"
                     /transl_table=11
                     /translation="MLSFLKSLNLLLMFLLELAVYVAVVLWGVAVGDGWPVEVALGVGA
                     PVVMMTAWALFGSPRAAHPARGAWRVVLEVFWFGAGAAALAASGRPRWAVAFAGACLVN
                     AALRRLWRQ"
     gene            complement(4872..5702)
                     /locus_tag="STPH1_RS12325"
                     /old_locus_tag="STPH1_2463"
     CDS             complement(4872..5702)
                     /NRPS_PKS="Domain: PKS_KR (3-155). E-value: 2.9e-09. Score:
                     29.0. Matches aSDomain:
                     nrpspksdomains_STPH1_RS12325_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119688.1"
                     /locus_tag="STPH1_RS12325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2463"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_164383369.1"
                     /sec_met_domain="adh_short (E-value: 1.6e-30, bitscore:
                     105.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKVWLITGASSGFGRAIAEAALADGDVVVGAARRPEALDGLVAA
                     YPDQMEALRLDVADTAAAGDAVRDVLARHGRVDVLVNNAGRTHVGALEETGEDELRALF
                     DVHVFGPAALTRAVLPSMRERRSGAIVQMSSMGGQMSFAGFSAYSGTKFALEGMSEGLA
                     DEVRDFGIKVLIVEPGSFRTGLFQAGNAGISADSGVYAKVGETRGMIAGGDGGQPGDPA
                     RAAAVIRAALAAEHTPLRLPLGDDGVGAVLGHLDQIRADVEAWEKQTRATAFDD"
     aSDomain        complement(5238..5693)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STPH1_RS12325_PKS_KR.1"
                     /evalue="2.90E-09"
                     /label="STPH1_RS12325_PKS_KR.1"
                     /locus_tag="STPH1_RS12325"
                     /protein_end="155"
                     /protein_start="3"
                     /score="29.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VWLITGASSGFGRAIAEAALADGDVVVGAARRPEALDGLVAAYPD
                     QMEALRLDVADTAAAGDAVRDVLARHGRVDVLVNNAGRTHVGALEETGEDELRALFDVH
                     VFGPAALTRAVLPSMRERRSGAIVQMSSMGGQMSFAGFSAYSGTKFAL"
     CDS_motif       complement(5643..5693)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS12325_0001"
                     /evalue="1.20E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="STPH1_RS12325"
                     /protein_end="20"
                     /protein_start="3"
                     /score="11.6"
                     /tool="antismash"
                     /translation="VWLITGASSGFGRAIAE"
     gene            5804..6718
                     /locus_tag="STPH1_RS12330"
                     /old_locus_tag="STPH1_2464"
     CDS             5804..6718
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444320.1"
                     /locus_tag="STPH1_RS12330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2464"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_240469004.1"
                     /transl_table=11
                     /translation="MTMDVHVRELRYFVTVAEELHFTRAAELLYVSQPALSKQIRALER
                     QVNAELFRRDHQGVALTEAGTALLPHARRVLAGWAEGAAAVEAVREARRGTLVVGMSTS
                     PGRGGLLPAIRSRFTAARPEAVLRLRQLSWEDSTAGLADGTADVAYVWLPLPDAGRYAW
                     TVVAEEPRLVALPDTHPLACHAELDFADLVAEPFLALPPEAGVLRDFWLALDERRALGA
                     GPPRVGAEISGTEETYEALVAGLGVCLVATGNAPLITLGGVGTRPVRGLSPSRYALAWR
                     REDEGRALVRGYVEACRRVTAGG"
     gene            complement(6679..7314)
                     /locus_tag="STPH1_RS12335"
                     /old_locus_tag="STPH1_2465"
     CDS             complement(6679..7314)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444322.1"
                     /locus_tag="STPH1_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2465"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_164383371.1"
                     /transl_table=11
                     /translation="MDAGADDVDDVLDTVGPRLRALRRERGITLAHLSAATGVSESTLS
                     RLESGQRRATLELLLPLARIYDVPLDDLVGAPRTGDPRIHLKPVRRFGMVFVPLSRRPG
                     GTQAFKMIIPSRPAPLEPTPQTHEGSEWLYVLSGRLRLLAGERDLTLTPGEAAEFDTSL
                     PHWLGSADGGAVELLVLFGLQGVRAHVRDGGARASGQPPAVTRRQAST"
     gene            7525..8178
                     /locus_tag="STPH1_RS12340"
                     /old_locus_tag="STPH1_2466"
     CDS             7525..8178
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (44-147). E-value: 1.2e-09. Score:
                     28.7. Matches aSDomain: nrpspksdomains_STPH1_RS12340_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444319.1"
                     /locus_tag="STPH1_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2466"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_164386336.1"
                     /transl_table=11
                     /translation="MNPTGPTSPTSAAEAVTFWDGVYAARPAPDAPRPNVRLVETVTDL
                     PPGTALDLGCGSGGDALWLARRGWRVTAVDISGVAAERLAGHARAHGLGDRVDAVRHDL
                     RASFPGGRFDLVCAHYLHTPFDLDRAAVLRTAAHALRPGGRLLVVDHGSTAPWSWDQDP
                     DARYPAPREVAAGLALDPATWRVERAEAVRRTATGPDGRTAEVVDHVLLVHRTG"
     aSDomain        7657..7965
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STPH1_RS12340_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.20E-09"
                     /label="STPH1_RS12340_oMT.1"
                     /locus_tag="STPH1_RS12340"
                     /protein_end="147"
                     /protein_start="44"
                     /score="28.7"
                     /tool="antismash"
                     /translation="LPPGTALDLGCGSGGDALWLARRGWRVTAVDISGVAAERLAGHAR
                     AHGLGDRVDAVRHDLRASFPGGRFDLVCAHYLHTPFDLDRAAVLRTAAHALRPGGRLL"
     gene            8205..8693
                     /locus_tag="STPH1_RS12345"
                     /old_locus_tag="STPH1_2467"
     CDS             8205..8693
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030051.1"
                     /locus_tag="STPH1_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2467"
                     /product="DinB family protein"
                     /protein_id="WP_164383372.1"
                     /transl_table=11
                     /translation="MSTTPRRDAPPPRTGDSEAETLRGFLDYLRTSVAGKVEGAPEPQV
                     RTAAVPSGTNLLGLLNHLTHVERALFLGEEVRSWPATFRAAPRDGVADVVARYREAVER
                     ANRVLDACADLGAPLPRPRPGRPAPSARWALAHMIEETGRHAGHADILRELIDGTTGR"
     gene            complement(8736..10004)
                     /locus_tag="STPH1_RS12350"
                     /old_locus_tag="STPH1_2468"
     CDS             complement(8736..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522324.1"
                     /locus_tag="STPH1_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2468"
                     /product="hypothetical protein"
                     /protein_id="WP_164383373.1"
                     /transl_table=11
                     /translation="MTDTTAGDPPRIGPATRVALHDLAVRRDRDEWIVGRMVTRNFVAL
                     PAAGARAVELLGDGLSVARTEETLRAETGEEFDIADFVGDLTALGFVARIGDRPVPDAE
                     PPRASLPWLRPRHVRLALHAALPLLVGALLTAAVVVLVRRPDLLPGYRDLLWSRHGSVV
                     LLSGAAAGWTLLLAHELAHLVTARAAGVPGRMRLGTRLQFLVMQTDISGIELAPRRHRL
                     TAYLAGIALNLSVASCLVLVLAATEPGTTAHRLLAAALLLALLPLPFQCMVFTRTDLYF
                     VLQDLTGCRDLYGDGLAYARYRFRRAVRPVRRVARGKAPALARDDPSTRLPAHERRAVR
                     IYSVVLVVGTAACLTFMAAVTLPVDIALLVRAVRGLGPEHGLAGNADAVTVLVVLGGVN
                     VLWLVTWWRNRRARRARRATGAA"
     gene            complement(10001..11194)
                     /locus_tag="STPH1_RS12355"
                     /old_locus_tag="STPH1_2469"
     CDS             complement(10001..11194)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387620.1"
                     /locus_tag="STPH1_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2469"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_205616671.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 4.2e-26,
                     bitscore: 89.6, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 2.7e-41, bitscore: 140.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVHPMRRPRIKPEHRAYRTVDGHVRIGSVVHGIGAEVRDDDGWV
                     WTLVQVMDGTRSAPDVVAEVAGRHPELRLPAPDIAQAMTDLTDAGYVEDAGAEPPAELS
                     ERERERYGRGMTLLRWMDLRPRDSAWEPQLLLRRAEVLLVGVGGTGSAAARDLVASGVG
                     RLHCVEPDVVELSNLNRQTLFREEDLGRPKLDAALTALRALNPDVEVTGERREVRGPAD
                     LEDLLTGARGASGYDALLLAADRPAAIRRWANQVCLATGTPWAEAGYRGPLVAVGVFTP
                     GRGACWQCLRDAEAERRDLRLGPGQDEDAASPRMPWNPANAVTAGLSGGLLAHAALMLL
                     CGVPPVEPGCRFGLNLMMPGDPVLQRSPRRPDCPACRRAENGPAPAARSGSGDRGSS"
     aSDomain        complement(10892..11179)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_STPH1_RS12355_Pantocin_Microcin_RRE.1
                     "
                     /evalue="1.70E-28"
                     /identifier="RREFam017.1"
                     /label="STPH1_RS12355"
                     /locus_tag="STPH1_RS12355"
                     /protein_end="101"
                     /protein_start="5"
                     /score="89.6"
                     /tool="antismash"
                     /translation="MRRPRIKPEHRAYRTVDGHVRIGSVVHGIGAEVRDDDGWVWTLVQ
                     VMDGTRSAPDVVAEVAGRHPELRLPAPDIAQAMTDLTDAGYVEDAGAEPPA"
     gene            11488..12792
                     /locus_tag="STPH1_RS12360"
                     /old_locus_tag="STPH1_2471"
     CDS             11488..12792
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387607.1"
                     /locus_tag="STPH1_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2471"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_164383374.1"
                     /transl_table=11
                     /translation="MHRYPTVAEVTESARRLVSRFPGSGRLRRIGTSRAGRPVLMLSVG
                     HGPRHVLVVARPHPDEPVGGATALALAERVATGDRRSPATDPETVTWDIVLCLDPDGAA
                     LSEGIEAATAGPGATLARYYRAAFRPVAAEQPEWAPIVGRRLPESHALFDTIDALRPVL
                     QCSLHNVDAGGAWVQLTGDLPGLAAPFAASASALGVPVQHGTYDALYWENPAPGVHVLP
                     PPDSTARLAAGSENIGRSTWCAPQRYGGVTAIVEVPLWSTGTADDPTPHPDPARALREL
                     SHLVREGGRHVTAVFDKARGFLPSAEDSPPGRVLEWMADDLYDLVADSWQPLVRQAESA
                     PRADRSPALTTAGISALEVVARRQPLRAAGLLLRLLDATDAPASVALRHELDGLFTTWC
                     TDFETSLRLRPVPVRTQVELQTRTVLAAAECALMR"
     gene            complement(12890..14380)
                     /locus_tag="STPH1_RS12365"
                     /old_locus_tag="STPH1_2472"
     CDS             complement(12890..14380)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973911.1"
                     /locus_tag="STPH1_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2472"
                     /product="carboxylesterase family protein"
                     /protein_id="WP_164383375.1"
                     /transl_table=11
                     /translation="MKHRPDPVVTTAQGAVRGLRRGDTLTFLNIPYAAPLHGAGRFAPP
                     LPHEPWDGVRDATVPGPNAPQSERRLGDVDMTPYFGTGWSRGEDYLTVNVFAPAAGGDA
                     LPVMVFVHGGGFVAGATRAALYDGSAFARDGVVLVTLNYRLGIAGFLDLPGAPANRGLL
                     DVVAALRWVRENISAFGGDPHHVTLFGQSAGATIVGGVLATPEAAGLVRRAIVQSGSGL
                     GAFTPEQAARVTGAAAGALGVEPHADAFAGLPDERLVEAASGLAGLDLRTGTHRDPLIG
                     LSPFSLVLDTQPAVSVAAGLAADVDLLVGTNAEEGNLYLVPVGAYATSTAADVDEAAAR
                     AHPDPVRLVETYRKSRPEAGFAELRSAVMADALFGAGSRALAGAHAAHPRSGTYAYEFA
                     WRSHALDGRLGATHTVELPFVFDLADRPELNGPHALLGPDGAPADLATRVHETWIRFAR
                     TGDPGWDPYDTDRRATMRIGAEWTRVDDPRSEERRAWS"
     gene            complement(14467..15390)
                     /locus_tag="STPH1_RS12370"
                     /old_locus_tag="STPH1_2473"
     CDS             complement(14467..15390)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387617.1"
                     /locus_tag="STPH1_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2473"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_164383376.1"
                     /transl_table=11
                     /translation="MDTITLGDVTVTRVREYYGPVDLTPEAFVPDSPARAWETHRSWLV
                     PDFLDAGTRIVNSAIQTWVLRSEGRTVLVDTGVGNHKDRPYAPVWNRLDTDFLGNLARA
                     GVRPEDVDIVINTHLHVDHVGWNTYLDGRTWVPTFPNATYLMARADFDYWNPANEIRTR
                     LGRGNQNVFEDSVAPVHEAGLTRLWEGSHRIDGNLRLDLAPGHTPGSSVLRLESGSDRA
                     LFVGDLMHNPIQIVEPDANSCFCEDPAEARATRHRLLGSAADGNALVFPAHLGGHGAAE
                     VVREGGKFAVKGWAPFAKYAEYTESA"
     misc_feature    15380..15398
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            15587..18430
                     /locus_tag="STPH1_RS12375"
                     /old_locus_tag="STPH1_2474"
     CDS             15587..18430
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387605.1"
                     /locus_tag="STPH1_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2474"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_164383377.1"
                     /transl_table=11
                     /translation="MKHGERARAGRDAPGDRRGAPGDPGPTVVGRESETAEIMGRLAAD
                     RSRGAVLVVEGGPGAGKSVLLDLAVRRTRGAGHRVLRAVGSESEARLAYAGLHQLLRPV
                     LGDLDALPARQRSALRAALGLTGHAEAPDAPDALLVGLAVLTLVSDLAEPAAPLLVVVD
                     DAQWIDRASLDVLSFLARRLDGEPVTLLLGVRAAAVLPGFDKGYARLEVGPLSGDAANR
                     LLDEQPEPPTGRTRVRILREAAGNPLALVELSRAVAGRRPEDLAVEGPLPVTDRLEALF
                     ALRVSHLPEATCRALLLLAAADAADAPAAARGPSEADGTAWAPAERAGLVRQDSAGISF
                     RHPVVRSAVYHAASFRERRQAHLALARLLGDDPDRRAWHLAAATVGPDEQVSAVLLETA
                     ARARRRGGHAAAAAALERAAELSPRRADQARLLADAADTAVFTGQLGWVAHLADEVRRR
                     SDDPALISRAALAAGRLMIMGPRHTAAFALLARIADEAADARSPRLLDALAAAAVVRYY
                     SGEESQRQRIETLLADLPDTATGGALGTWVRAVSDPVGAGASLAPALPRLIDEAKHDAG
                     TLTALAVVAWLLDRTALAARTFDEAADRWRAHGPLPTGLGCAVGWTYLEQGRWAEARSV
                     AAEIAAVAAQSGLDHAEACARALDAAAVALLGEPADARENAERALALVDPLESRSVAVA
                     ARRALGMAAVAEGDYDTAYAHFRSAFTEDGDPVHYHVSYTVLAELAAAAARRGQCAPAA
                     ELLERSVRRLGTGMSARLALLVERARALLADPEHAERHFRAALANETGDQWPFERAQTR
                     LDYGEWLRRQRRIAEARPLLTGALDTFRRLGARPWIERTKAELRAAGIEATGAAPGALT
                     ELSPQQQQIVRLAARGLTNREIGEKLFLSPRTVGSHLYRVFPRLGITARAQLRDVVDDT
                     RPRPPDRHRGAGAPAAR"
     gene            complement(18569..19987)
                     /locus_tag="STPH1_RS12380"
                     /old_locus_tag="STPH1_2475"
     CDS             complement(18569..19987)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011211317.1"
                     /locus_tag="STPH1_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2475"
                     /product="ATP-binding protein"
                     /protein_id="WP_164383378.1"
                     /transl_table=11
                     /translation="MVDFVGRRQELATLERELSKVAAGVRGERPGRCVMLRGRRRVGKS
                     RLVERFAERSGVPFLFYAATGASPEDDLARLARDAQASTLPLAQLVAAARPASWDAAFD
                     VLAAALPADRASVLVIDEVPYLMDADGAFEGMLQRAWDRVLETKPVLLVLIGSDLSMME
                     ALNSYGRPFHQRGREMVLGPLNPAEAGRMLGLDPAEAFDAALVTGGLPLICAEWPHGAG
                     LWDFLGEALSDPVSALLVSAERSLAAEFPPQAQARTVLAAIGSGERTFTNIARAAGGIG
                     ATPLQRALELLAEKRVVVGELPVSPRPSKDRRYRVADPYLRFWLHLLGPSMEEIERGRG
                     DLTLARIRENWTSWRGRAVEPLVREALARILPDDRLPAAPAVGGYWTRTNDVEIDIVGA
                     DRAPVAKELLFVGSIKWLEQSSFDRHDLAALHRHRAALTDAPVPVVAVSRSGVDCRGLD
                     AAYGPGDLLTAWPL"
     misc_feature    complement(20013..20030)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.53"
                     /tool="antismash"
     gene            complement(<20118..20808)
                     /locus_tag="STPH1_RS12385"
                     /pseudo=""
     CDS             complement(<20118..20808)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="STPH1_RS12385"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKCFLSVVSIGVLRRCAGLTSLAERMVPEELWELFRRPMPAKVVL
                     HPQGGGWRRAGDCECLAVIIFVATSGCFWRRLSPVFGPAWPTVYRRFAQWSKVHVWARL
                     HRVILDELESPASWTGRGARSTPSACEPPEGAPDGTESDRPRQKRIENPPHRRPQRPFP
                     SRLAPPAPTPTAARPATADLLRPTRPQPPRTAPKAIGQAARRRGLRLRPPPSMGPSSRH
                     HAPHRPLR"
     misc_feature    complement(20674..20676)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(20794..20796)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21112..21128)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.92"
                     /tool="antismash"
     misc_feature    complement(21120..21137)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.25"
                     /tool="antismash"
     misc_feature    complement(21120..21140)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.53"
                     /tool="antismash"
     misc_feature    21151..21165
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.22"
                     /tool="antismash"
ORIGIN
        1 cgcgccgtcc gcccggccgc gacccggacc cggcgccgcc gtccggtgcc cggaagggga
       61 ccacgccggt ccactcccgg ccgtcgagga tctcagtcat cttgcgccgg ccgcgctcgc
      121 gcagatcggg gtcgatgaag gcctcgatgg ggtcggtacc cacggcgtct tccgcccgga
      181 tgccgagcag ttgctccgcc cgcaggctcc actggtcgac gagcccgtcg ggaccgatgg
      241 agaaggacgc gaccttgacg tagtcgtaga tggagccggg cgggctgctc tgccacaccg
      301 cgtcaccgag gggcgcgtct tgcgacggac ccccggactc cgtggactcc gtgggctcct
      361 cggccctcgc tggtatctcg ctcacgcgaa ccgtcccctc cagctcaccg cgtccggcac
      421 cggtcaccgg aggcggctgc ccgcagtatc cagcactacg gcgccgcacg acacggtgtt
      481 cacgatcaca gcacggtccc gatggttttc ggtccggacc gtgacaacac ttccagtctt
      541 ctaaccagcg gacacggcat cgaatcacgc agttccacaa ctgccgctgg cctgaaccgg
      601 ttgacggccg cagtcagggg tgatgtcggt acattccgga cacctgtcgc cgcgatggca
      661 acgctgtgtc acgagaccgt cgcgtcagcg cggcagggcg agttcgaacc acaccgtctt
      721 gcccgcctcg ccggggcggg tgccccagcg ccgcgtcacg gacgccacca gttgcagacc
      781 gcggccgtcc tcgtcgtcgg cgcgggcgac gcgctcgcgg ggcgggtcgg gcagcgggtc
      841 ggacacctcg accagcagga ccccggcggc tccggccggg tcgcgcacca ggcggacgcc
      901 gatgggtccg gtggcgtgcc gcagggcgtt ggtgaccagc tcgctgacca gcagggcggt
      961 gaggtcggcg actccgccga ggcgccactc gtccagcgtg cggcggacca gggagcgggc
     1021 ggtccgcacg gcgtccgggg ccgcggggaa gacccactcg gcacagtcgc cctcgtcgtc
     1081 gctcacgccg atcacttccc cggccgacaa ccccccaccg gtgtcccttt tcgtggggtt
     1141 aatgggcaca taccctttat ccgggcccgg taccgctcat ccgggcccgg taccgcgcgc
     1201 cgcgccactc gccccgagtc ccaggtgggc gagcacccgc tcgacggcgg gtacgtcctg
     1261 ctcgagccag ggaacgtccc agacctgggc gggggtcagc cagcgcaggt cgtcgtggtc
     1321 ctcgaggggt tggggggcgg cggagccggg gagcaggcgg gcggtccaca cctggaggac
     1381 gaagggcgcc cgcaggggcc actgtcccgg gacgcgctct ccggcctcgg ccgccactcc
     1441 cagttcctcg cgcagttcgc gctcgagcgc cgcctcgggc gtctcccccg cctcgacctt
     1501 gccgccgggc agttcccagc gcccggccag ttccgcgggc gcgctccggc gtgcggcgag
     1561 caggcgcccg ccgtcgagca gggcggcacc caccacgatc cgttccgtca tgcgccggag
     1621 cctacggcct gtccggccgg ccccggcccc gcccccgcgg gagggcgccg gtcagtcggc
     1681 cgtgcccgtg cccgccgcgc cgagcctctc gacccagtag agctgctggt gtccgcgacc
     1741 gtcgagggtg tccgcgatct gctgggcctc ggcccgggtc gcgtacctgc ccacgcgata
     1801 gcgattgccg ttgtcgtcct gccggaagac cagccaggga agagtgaccg tgctgtcgtt
     1861 catcgcgccc ttccacctcc cgttcccgcc cgcggcactc gccgcgcccc gcccgccaag
     1921 gaaaccgcag tccgcatatg cccgagcgta cgcccaacct tcacggagcg aatacgactt
     1981 tgcacaaaga ggtacgcaac cagccagaac gcagggggcg cacgatgcag aacgcgccgt
     2041 ccacgcacac cgatgcctcc ggtcacaggc atggcggggc cgactgacgc gacctgcggg
     2101 aacggccgga ttacggcgcc gcgcgcggag gtgccgaggt tcggcccggg tgcgggcagg
     2161 cgcgcgtgcg gcggaaagcg gcgcgggagg cgcacgacgg gcgtgcgcca tctcacaccg
     2221 tggcggcggt gaaccgccct ggaccgggcg gcggttgccg ggctacctga ccggcaggtg
     2281 gtaggcgacc cggtaccggt cggccgggac gaccacgtcg gccgtctcca ccgcgcgccc
     2341 cgaggcgtag aaggtgcgct ggacgaccag caccacgtgc cccggtacgc cgcccagcgc
     2401 gagcagctcc tcggcgaggc cggggcgggc gccgacctcc tcggtgacgt tgtcgacgac
     2461 gacgtcgatg gcggccatcc gctcgacgac gcccatgccg ccgagcggcc cctcctcggg
     2521 gagcatcacc ggggtgcgcc cggtcaggtc cagcggctcc caggaggtgg agagcatgac
     2581 ggcctcgccg gactcccgga agacgtaccg ggtgcacatc acccggtcgc cgggcttgat
     2641 cccgagccgc tcggccacgg caccgctcgc ctcggcctgc tcgctgcgcg attcccaggt
     2701 gccgcgcgcg tcggcgtcgg cctgctcctg ccggaagggc gtggcgccac ccgccggccg
     2761 gtacccggag cgggcgacgc gcctggggac gggccgctcg cgcacgtagg tgccggagcc
     2821 ggagcggccc tcgaccagcc cctcggccat gagcaccttg cgggcctcca gcgcgacggt
     2881 gtccgagacg ccgtactcct cgcggatccg tgcctgggac gggaggcggg tatgaggcgg
     2941 cagcaggccg tcggcgatct tcttgcggag atcacccgcg acacggagat acgccggctg
     3001 ctcaccgaat gtcactggcc gctcccatca ggttgtacag acagcaacag cgtggcaacc
     3061 gccggtcgac cgggcaagca aaggccaaag aatcactcga tgtgatgact tctgcggtcc
     3121 gagggcttta cgcaggcact ttctccccgc tatgggcgcc ctcacacctc cctgccgggg
     3181 ctctctcccc cgtcgccgcc ggactccgcg tactccggcg gcgtggtgtc gaggccgagg
     3241 gactcgcggg cggtgaccgt ggtgtcgccg tcgatgagcg cgtagccctg gtagaggtgc
     3301 tcgtagaatg cgtccgcgtc gggggtcgcc tccgccgcgg cgaactcctc gcgtgccgcc
     3361 tccaggtcgg tgaccagctc gctgaccggc tgctcgctcg cggacggcca ggagtgcgca
     3421 cccagcatgc cgatctcctc ggtgagcgcg ttctccaccc ggcccgccca cgcctgttgc
     3481 gcggtcgggt cgtcctcgaa gtactcgttc tccggcgtcg actccagggc cccgtccagg
     3541 gcccgcgccg cctccaggta cgcgatctgg tgcgcgtcga gcgtcgtcgc gtcgttgcgc
     3601 agcgaaccgg tcaggttctt ccgctcgtcc gtgctgccga acaggcaggt gatctcccgg
     3661 tcgttcgaca gccagctgcg ccgggtcggc gtcaggtagt acacgtcgac atcggcgggc
     3721 agggcccagt cgtccatggc gtactcgccc acgagcccgt agcagcgcag gtcggccatc
     3781 gacgtgagcg cgtcgtcccc cgggtacgag ccgccgcgcg gcaggtcgaa cacggcgaac
     3841 acctcgccgt cgtgctccgc ggcgcacggc acctggtcga cgtcgtacgt caccccctgg
     3901 agagagcccc cgggtgtggt gaagcactcg cccttctcca gcgcgtacgc ggtgccctcg
     3961 ccgcgcgcgg cgtcccggaa accctcccag aagtcggcca cggcgcccgt ggagagcgtc
     4021 agcgcccaca gggccagccc cacggaggac aggacgcagc cggccaccgc gaaccccttg
     4081 ccccgctcgc cccgcttccg gatccggacc agcgcgatca gccccagcac gagcccgacc
     4141 gccggcacga agcacaggac gccgagcacg aacgcggcga cggcgagccc gttcacgggg
     4201 gcctgccggg ggtacggacc gagggggtgg ccccactgcg gagcgtacgg gccctggggg
     4261 tacggccctt ggggtcccgg cggtggcggt atcgacacgg gtgccttgct cctgttcgcg
     4321 agggtggtgc gccgacggtg cggcctcgcg catcgtaagc ggcccggacg ggaggcggcc
     4381 cgcgggccgc ggacgcgccg ggtgccctca ctgcctccac agccgtctga gcgccgcgtt
     4441 gaccaggcag gcaccggcga aggcgaccgc ccagcgcggt ctgccggagg cagccagggc
     4501 ggccgcgccg gcaccgaacc agaacacctc caggacgacc cgccacgccc cgcgcgcggg
     4561 gtgtgcggcg cggggcgacc cgaacagcgc ccacgccgtc atcatcacca ccggcgcgcc
     4621 cacccccagg gccacctcga ccggccaccc gtcgccgacg gcgacccccc agagcacgac
     4681 cgcgacgtac accgccagtt ccagcaggaa catcagcagc aggttgaggg acttcaggaa
     4741 cgagagcacg acggactcct ggctcggaca cggacacgga cacggacacg gacacggtcg
     4801 ggtgcggaga ccaaggtgtc agcccgcgcg ccatggccgg aacagagccg gggaatccgt
     4861 cgcgcggcgg ctcagtcgtc gaacgcggtg gcccgggtct gcttctccca cgcctcgacg
     4921 tcggcacgga tctggtcgag atgaccgagg accgcgccga cgccgtcgtc gcccaggggc
     4981 aggcgcagcg gggtgtgttc ggccgcgagg gcggcccgga tgacggccgc cgccctggcc
     5041 gggtcgccgg gctggccgcc gtcgcctccg gcgatcatcc cgcgggtctc gccgaccttg
     5101 gcgtacacgc cgctgtccgc gctgatcccg gcgttgccgg cctggaagag gccggtgcgg
     5161 aaggagcccg gctcgacgat cagcaccttg atgccgaagt cccggacctc gtccgcgagc
     5221 ccttcggaca tgccctccag cgcgaacttc gtgccgctgt acgccgagaa gccggcgaag
     5281 gacatctgcc cgcccatgct gctcatctgc acgatcgcgc ccgagcgccg ctcccgcatg
     5341 gacggcagca ccgcgcgcgt cagcgcggcc ggcccgaaga cgtgcacgtc gaacagcgcg
     5401 cgcagttcgt cctcgccggt ctcctcgagg gcgccgacgt gcgtgcggcc cgcgttgttg
     5461 acgagcacgt cgactctgcc gtgccgtgcc agcacgtccc gcaccgcgtc cccggcggcg
     5521 gccgtgtcgg cgacgtccag gcgcagcgcc tccatctggt cggggtacgc ggccacgagg
     5581 ccgtccagtg cctcggggcg ccgtgccgcg ccgaccacga cgtcgccgtc ggccagggcc
     5641 gcctcggcga tcgcccgccc gaagccgctg ctcgcaccgg tgatcagcca gaccttgttc
     5701 ataccgactc ctcgtgtccc gttcacatcc gtcgctccga cgccaaccac cctcgtccac
     5761 aagccggttg ccggtccaag acccacggtg ataacccatg gttatgacga tggacgtgca
     5821 cgtgcgggag ctgcgctact tcgtgacggt ggccgaggaa ctgcacttca cgcgggcggc
     5881 cgaactcctg tacgtgtccc agcccgcgct gagcaagcag atccgcgccc tggagcggca
     5941 ggtgaacgcc gaattgttcc gccgcgacca tcagggcgtg gccctcaccg aggcgggcac
     6001 ggcactgctg ccgcacgccc ggcgggtgct ggccggctgg gccgagggcg cggcggcggt
     6061 ggaggcggtc cgggaggcgc ggcgcggcac cctggtcgtc ggcatgagca ccagccccgg
     6121 acgcggcggg ctgctgccgg cgatccgctc ccgcttcacg gcggcccgtc cggaggcggt
     6181 cctgcggctg cggcagctga gctgggagga ctcgaccgcg ggcctggccg acggcaccgc
     6241 cgacgtcgcg tacgtgtggc tgccgctgcc cgacgccggc cgatacgcct ggacggtggt
     6301 cgccgaggaa ccccgcctgg tcgccctacc cgacacccac ccgctcgcct gccacgcgga
     6361 gctcgacttc gccgacctcg tcgccgagcc gttcctcgcc ctgcccccgg aggcgggagt
     6421 gctgcgcgac ttctggctgg cgctggacga gcggcgcgca ctcggcgccg gcccgccgcg
     6481 ggtcggtgcc gagatctccg gtacggagga gacgtacgag gccctggtcg cgggcctcgg
     6541 cgtctgcctg gtggccacgg gcaacgcgcc gctgatcacc ctgggcggcg tcggcacccg
     6601 cccggtccgc ggtctgagcc ccagccgcta cgcgctggcc tggcgccgcg aggacgaggg
     6661 gcgggcactg gtccggggct acgtggaggc ctgccgccgg gtgacggccg ggggctgacc
     6721 ggaggctcgg gcaccgccgt cccgcacgtg cgcgcgcacc ccctggaggc cgaagaggac
     6781 gagcagttcg accgcgccgc cgtcggcgct gcccagccag tgcggcaggg acgtgtcgaa
     6841 ctccgccgcc tcaccgggcg tcagcgtgag gtcgcgctcc ccggccagca gccgcagccg
     6901 gccgctgagc acgtacagcc actcggagcc ctcgtgggtc tgcggggtcg gttcgagcgg
     6961 tgccggacgg ctcgggatga tcattttgaa cgcctgggtg ccgcccggcc gccgggagag
     7021 cggcacgaag accatcccga agcgccggac gggcttcagg tggatgcgcg ggtcgccggt
     7081 gcgcggggcg ccgacgaggt cgtccagggg cacgtcgtag atccgggcga gcggcagcag
     7141 cagctccagg gtcgccctgc gctgcccgct ctccagccgc gacagggtgc tctccgacac
     7201 tccggtcgcc gccgacaggt gggcgagggt gatgccccgc tcgcggcgca gcgcgcgcag
     7261 gcgcgggccc accgtgtcga gtacgtcgtc cacgtcgtcc gctccggcgt ccatcgggcc
     7321 accttgccac aacggcaagt tctcgtgccg gatcggacgg ccgctgccaa gactggccgc
     7381 atcgtccgtc gcccgcggct gccggcccag cccggccgga cccgaacgag cccgagcgaa
     7441 cccgaacgag cccgaacgag cccgaacgaa ggagtcccgg tgagtccgaa caatccgatg
     7501 agcccgatga gcccgatgag cccgatgaac ccgacgggtc cgacgagtcc gacgagtgcc
     7561 gccgaggcgg tcaccttctg ggacggcgtg tacgcggccc gcccggcgcc cgacgccccc
     7621 cggccgaacg tccgtctcgt cgagacggtc accgatctgc ctcccggcac cgcgctggac
     7681 ctggggtgcg gcagcggcgg ggacgcgctg tggctcgccc ggcggggctg gcgggtcaca
     7741 gccgtggaca tctccggcgt ggcggccgag cggctcgcgg gacacgcccg cgcgcacggc
     7801 ctcggcgacc gggtggacgc cgtacggcac gatctgcgtg cgtccttccc cgggggccgg
     7861 ttcgacctgg tctgcgcgca ctacctccac accccgttcg acctggaccg ggcggcggtc
     7921 ctgcgtacgg ccgcgcacgc gctgcgcccc ggcgggcggc tgctggtcgt cgaccacggc
     7981 tcgaccgcgc cgtggtcgtg ggaccaggac cccgacgccc ggtacccggc cccgcgggag
     8041 gtcgcggcgg gtctcgccct cgacccggcg acgtggcggg tcgaacgggc cgaggccgtg
     8101 cgccgcaccg cgaccggccc ggacgggcgc accgcggagg tcgtcgacca cgtcctgctc
     8161 gtccaccgca ccggctgaag gcacacgtcc cccaggaggt caccatgtcc accacgcccc
     8221 gccgggacgc gccgccgccc cgcaccggag acagtgaggc cgagaccctg cgcgggttcc
     8281 tcgactacct gcggacctcg gtcgcgggca aggtcgaggg agccccggaa ccgcaggtcc
     8341 gcacggccgc ggtgccgtcc ggcaccaacc tgctcgggct gctcaaccac ctgacccacg
     8401 tcgaacgcgc cctcttcctc ggggaggagg tgcggagttg gccggcgacg ttccgggccg
     8461 cgccccggga cggcgtggcc gatgtcgtcg cccgctaccg ggaggccgtc gaacgcgcga
     8521 accgcgtcct cgacgcctgc gccgacctcg gcgccccact cccccggccc cgtccgggcc
     8581 gccccgcgcc cagcgcccgc tgggccctcg cccacatgat cgaggagacc ggccgccacg
     8641 ccggtcacgc ggacatcctg cgcgagctga tcgacggtac gacgggacgc tgagcgcgcc
     8701 gccccgtggc gtgccccgcg tgccgtgccc cgccctcagg ccgcgcccgt ggcccggcgg
     8761 gcgcggcggg cgcggcggtt gcgccaccag gtgaccagcc agaggacgtt gaccccgccc
     8821 aggaccacca ggaccgtcac cgcgtcggcg ttgcccgcca ggccgtgttc cggtcccagt
     8881 ccccgcacgg cgcggaccag gagggcgatg tcgacgggca gggtgaccgc ggccatgaac
     8941 gtcaggcagg ccgccgtacc caccacgagg acgacgctgt agatccggac tgcccgccgc
     9001 tcgtgcgcgg gcagccgggt gctcgggtcg tcccgtgcga gcgccggtgc cttcccgcgg
     9061 gcgacgcgcc gcaccggccg caccgcgcgc cggaaccggt accgggcgta cgccaggccg
     9121 tcgccgtaca ggtcccggca gccggtgagg tcctggagga cgaagtacag gtcggtgcgg
     9181 gtgaagacca tgcactggaa gggcagcggc agcagggcga ggagcagggc cgcggccagc
     9241 aggcggtggg cggtcgtccc gggctccgtc gcggcgagca ccaggacgag gcacgacgcg
     9301 acggacaggt tgagggcgat tccggccagg taggccgtca gccggtgccg gcggggggcg
     9361 agttcgatgc cgctgatgtc ggtctgcatg acgaggaact gaagccgggt gcccagccgc
     9421 atccgccccg gcacgcccgc cgcccgggcg gtgaccaggt gcgccagttc gtgggccagc
     9481 agcagcgtcc acccggccgc cgcaccgctc agcaggacca cgctgccgtg gcggctccac
     9541 agcaggtcgc ggtagccggg aagcaggtcg gggcggcgca ccaggacgac gacggcggcc
     9601 gtcagcagtg ccccgacgag cagcgggagc gccgcgtgca gggcgagacg gacgtggcgg
     9661 ggccgcagcc acggcaggga cgcccgcggc ggttcggcgt cggggaccgg acggtcgccg
     9721 atccgcgcca cgaagcccag cgcggtcagg tccccgacga agtccgcgat gtcgaactcc
     9781 tccccggtct cggcccgcag cgtctcctcc gtacgcgcca cgctcagccc gtcgcccagg
     9841 agttccaccg cgcgcgcccc ggccgccggc agggcgacga agttccgggt gaccatgcgg
     9901 cccacgatcc actcgtcgcg gtcgcgtcgt acggccaggt cgtgcagggc gacacgggtc
     9961 gccggcccga tccggggagg gtcgccggcg gtcgtgtccg tcacgaggag cctcggtccc
    10021 cggagccgga acgggcggcc ggggccgggc cgttctccgc gcggcggcag gccggacagt
    10081 cggggcgccg cggcgagcgt tgcaggaccg ggtcgcccgg catcatgagg ttgaggccga
    10141 accggcatcc gggttcgacg ggcgggacgc cgcacagcag catcagggcg gcgtgggcca
    10201 gcagcccgcc cgacaggccc gcggtcacgg cgttggccgg attccacggc atgcggggcg
    10261 aggccgcgtc ctcgtcctga ccggggccga gccgcaggtc gcggcgttcc gcctcggcgt
    10321 cgcgcaggca ctgccagcac gcgccccggc ccggcgtgaa gacgcccacg gcgaccagcg
    10381 gtccgcggta gcccgcctcg gcccacggtg tgcccgtggc caggcagacc tggttggccc
    10441 atcggcggat cgcggcgggg cggtcggcgg cgagcagcag ggcgtcgtag ccggacgcgc
    10501 cgcgggctcc cgtcagcagg tcctcgaggt cggccgggcc ccgtacctcg cgccgctcgc
    10561 cggtgacctc gacgtccggg ttgagcgcgc gcagggcggt gagcgccgcg tccagtttgg
    10621 gtctgccgag gtcctcctcg cggaagagcg tctgccggtt gaggttggac agttcgacca
    10681 cgtccggttc gacgcagtgc agccgcccca cgccggaggc caccaggtcc cgggcggcgg
    10741 ccgagccggt gccgccgacg ccgaccagca ggacctcggc ccggcgcagc agcagctgcg
    10801 gctcccaggc actgtccctg ggccggaggt ccatccaccg cagcagggtc atgcccctgc
    10861 cgtaccgctc gcgttcccgc tcggacagtt ccgccggcgg ctcggcgccg gcgtcctcga
    10921 cgtacccggc gtcggtcagg tccgtcatgg cctgggcgat gtccggggcc ggcagccgca
    10981 gttccgggtg gcgtccggcc acctcggcga cgacgtccgg ggcgctgcgc gtcccgtcca
    11041 tgacctggac gagcgtccag acccagccgt cgtcgtcccg tacctcggcg ccgatgccgt
    11101 ggacgacgct gccgatccgc acgtggccgt ccacggtccg gtaggcgcgg tgctccggct
    11161 tgatccgggg ccgccgcatc gggtgcaccg tcattttcgc gccaacctcg ccatccccca
    11221 ccacgcgggc cacaacggac gttgacaacg gtgcacgggt gagcgaacgc tgacaagagc
    11281 acgacgtgcc tcgcacgcca caagcaccac ggctgcagag cacgtcggcg tcacggcaca
    11341 cggcacacgg cacacggtca ccacggtcac cacggtcacc accggaagga gacggcatgg
    11401 cgaacaagat cgagatccgt ccgctggaca agaaggagac caccggcgac agcggtggca
    11461 acggcggctc ctgaccggac tcgcccgatg caccgctacc ccacggtcgc ggaagtcacc
    11521 gagtcggcgc gacggctggt ctcccggttc cccgggtccg gccgcctgcg ccggatcggc
    11581 acgtccaggg ccggccggcc ggtcctgatg ctgtcggtgg ggcacgggcc gcgccacgtc
    11641 ctggtggtgg cccgcccgca cccggacgag ccggtgggcg gcgcgacggc gctggcgctg
    11701 gcggagcggg tcgcgaccgg cgaccgccgg tccccggcga ccgaccccga gaccgtcacc
    11761 tgggacatcg tcttgtgcct cgacccggac ggcgcggcgc tgagcgaggg catcgaggcg
    11821 gcgacggccg gccccggcgc cacgctggcc cgctactacc gcgccgcctt ccgcccggtc
    11881 gcggcggaac agccggagtg ggcaccgatc gtcggccggc ggctcccgga gagccacgcc
    11941 ctgttcgaca cgatcgacgc gctccgcccc gtactccagt gctccctgca caacgtcgac
    12001 gcgggcggcg cctgggtcca gctcaccggg gacctccccg gcctcgccgc ccccttcgcg
    12061 gcgtccgcgt cggcgctggg cgtcccggtc cagcacggca cgtacgacgc cctgtactgg
    12121 gagaacccgg cccccggcgt ccacgtcctg ccgccaccgg acagcaccgc ccgcctggcg
    12181 gccgggtccg agaacatcgg ccggtccacc tggtgcgcgc cccagcggta cggcggtgtc
    12241 acggcgatcg tcgaggtgcc cctgtggtcc accggcacgg ccgacgaccc gaccccgcac
    12301 ccggaccccg cccgggccct gcgcgaactg tcccacctgg tccgggaggg cggacgacac
    12361 gtcaccgccg tcttcgacaa ggcccgcggc ttcctgccgt cggccgagga cagcccgccc
    12421 ggacgcgtac tggagtggat ggccgacgat ctgtacgacc tggtcgccga ctcctggcaa
    12481 ccgctggtcc ggcaggcgga gtcggcaccc cgcgccgacc gctcccccgc gctgacgacg
    12541 gccgggatca gcgccctgga ggtcgtcgcc cgacgccagc cactgcgcgc ggcgggactt
    12601 ctgctgcgcc tcctggacgc gaccgacgcc cccgcgtccg tcgccctccg ccacgaactc
    12661 gacggcctct tcaccacctg gtgcacggac ttcgagacgt cactgcgcct gcgcccggtc
    12721 cccgtccgca cccaggtgga actccagacc cgcacggtgc tggcggctgc ggagtgcgcg
    12781 ctgatgcgct gaagctctga cactctgagg ctctgaagct ctgatgcgct gaagcagtcg
    12841 ggacgggggc cggccagggg agttgcgggt cgatgacgtg agtgccgggt cagctccagg
    12901 cccgtcgttc ctcgctgcgg gggtcgtcga cccgggtcca ctcggcgccg atgcgcatgg
    12961 tcgcccggcg gtcggtgtcg tacgggtccc agccggggtc gccggtccgg gcgaaccgga
    13021 tccaggtctc gtggacgcgc gtggcgaggt ccgcgggggc cccgtcgggg ccgagcaggg
    13081 cgtgcggccc gttgagttcg ggccggtccg cgaggtcgaa gacgaagggc agttccacgg
    13141 tgtgcgtggc gccgagtcgt ccgtccaggg cgtgggagcg ccaggcgaac tcgtaggcgt
    13201 aggtgccgga gcgcgggtgc gccgcatggg cgccggccag cgcgcggctg cccgcgccga
    13261 acagggcgtc ggccatgacg gcggagcgca gttccgcgaa gcccgcctcg ggccgggact
    13321 ttcggtaggt ctcgacgagc cgcaccggat cggggtgcgc gcgggcggcg gcctcgtcga
    13381 cgtcggcggc ggtcgaggtg gcgtacgcgc ccaccgggac caggtagagg ttgccttctt
    13441 ccgcgttggt gccgacgagc aggtcgacgt cggcggcgag accggcggcg acggacacgg
    13501 cgggctgggt gtccaggacg aggctgaagg ggctgaggcc gatcagcgga tcgcggtggg
    13561 tcccggttcg caggtcgagg cccgcgagtc cggatgccgc ctcgacgagc cgctcgtcgg
    13621 ggaggccggc gaaggcgtcg gcgtggggct ccacgcccag cgccccggcc gcggccccgg
    13681 tgacgcgggc ggcctgctcg ggtgtgaaag cgcccagacc gctgccgctc tgcacgatcg
    13741 cccggcggac cagtccggcg gcctcggggg tggcgaggac gccaccgacg atggtcgccc
    13801 cggcggactg gccgaacagg gtgacgtggt gcgggtcgcc gccgaaggcg gagatgttct
    13861 cccgcaccca gcgcagcgcg gcgacgacgt cgagcaggcc gcggttggcg ggcgccccgg
    13921 gcaggtcgag gaacccggcg atgccgagcc ggtagttgag ggtgacgagg acgacgccgt
    13981 cccgggcgaa cgcggagccg tcgtacaggg cggcccgcgt cgccccggcg acgaagccgc
    14041 cgccgtggac gaagaccatc accggcaggg cgtcaccgcc ggcggcgggc gcgaagacgt
    14101 tgacggtgag gtagtcctcg ccccggctcc agccggtgcc gaagtagggg gtcatgtcga
    14161 cgtcgccgag cctgcgttcg gactgcgggg cgttgggtcc cggcacggtg gcgtcccgta
    14221 ccccgtccca cggctcgtgc ggcagcggcg gggcgaaccg gccggcgccg tggagcggag
    14281 cggcgtacgg gatgttcagg aaggtgaggg tgtcgccccg gcgcaggccg cggacggctc
    14341 cctgcgcggt ggtgacgacg gggtcggggc ggtgcttcat ctctcgtgtc cttccgtgga
    14401 ttctgcggtg ctccgtggat tccgtgggct ccgtgggctc cgtggattcc gtgggctccg
    14461 tggacttcag gccgactcgg tgtactcggc gtacttggcg aagggcgccc agcccttgac
    14521 ggcgaatttg ccgccctcgc gtacgacttc ggcggcgccg tggccaccga ggtgcgcggg
    14581 gaagacgagg gcgttgccgt cggcggccga gcccaggagc cggtggcggg tggcgcgggc
    14641 ttcggcgggg tcctcgcaga agcagctgtt ggcgtcgggc tcgacgatct ggatcgggtt
    14701 gtgcatcagg tcgccgacga acagggcccg gtcggagccg gactccagcc tcagcacgga
    14761 ggagccgggg gtgtggccgg gggcgaggtc gaggcgcagg ttgccgtcga tccggtggct
    14821 gccctcccac agccgggtga gaccggcctc gtgcacgggg gcgacgctgt cctcgaagac
    14881 gttctggttg ccccggccga gccgggtcct gatctcgttg gccgggttcc agtagtcgaa
    14941 gtccgccctg gccatcaggt aggtggcgtt ggggaaggtc ggtacccagg tccgcccgtc
    15001 gaggtaggtg ttccagccga cgtggtcgac gtgcaggtgc gtgttgatca cgatgtcgac
    15061 gtcctcgggg cgcaccccgg cgcgggcgag attgcccagg aagtcggtgt ccaggcggtt
    15121 ccacacgggc gcgtacggcc ggtccttgtg gttgccgacg ccggtgtcga ccaggacggt
    15181 cctgccctcg ctgcgcagga cccaggtctg gatcgccgag ttgacgatcc gggtcccggc
    15241 gtccaggaag tccgggacca gccaggaacg gtgcgtctcc cacgcccggg ccgggctgtc
    15301 cgggacgaac gcctcgggcg tcaggtcgac gggaccgtag tactcccgga cccgggtcac
    15361 ggtgacgtcg cccagggtga tggtgtccac ggtgtgctcc agtgcagaag gtcgggctcg
    15421 aacgcccctg ttccgcaaga gtgcgtcgcg ggtggcgggc cgcggtatgc gtcatgtgac
    15481 tgcacccggt tccgcccgac ctgtggtgtc cggccgcggg acggcaggaa tacggccacg
    15541 gcaccgccac gttgccgtca gggctgtctc agttcctgga gcatccgtga agcatggtga
    15601 acgcgcccga gcgggccggg acgcgcccgg agatcgccgg ggcgcgcccg gagatcccgg
    15661 tccgaccgtg gtgggccggg agagcgagac cgcggagatc atggggcgcc tcgccgccga
    15721 ccggtcccgc ggcgcggtgc tggtcgtcga gggcggcccc ggtgccggca agagcgtgct
    15781 gctcgacctc gccgtacggc ggacccgcgg tgccggccac cgggtgctga gggcggtcgg
    15841 cagcgagtcc gaggcgcggc tcgcgtacgc cggtctgcac cagctgctcc gcccggtcct
    15901 cggcgacctg gacgccctgc cggcacggca gcgttccgcg ctccgggcgg ccctgggcct
    15961 gaccggacac gccgaggccc ccgatgctcc cgacgccctg ctcgtcggcc tggcggtgct
    16021 gacgttggtg tcggacctgg cggagccggc agcaccgctg ctcgtggtgg tggacgacgc
    16081 ccagtggatc gaccgcgcgt cgctggacgt cctctccttc ctggcgcggc gcctggacgg
    16141 cgagcccgtg acgctgctgc tcggcgtgcg ggccgcggcc gtgctgcccg gtttcgacaa
    16201 ggggtacgcg cgcctggagg tcggccccct gagcggtgac gcggcgaacc gcctgctcga
    16261 cgagcagccg gagccgccca ccggccgcac ccgggtccgg attctgcggg aggcggcggg
    16321 caatcccctg gccctggtcg agctgtcccg cgccgtcgcg ggcagacggc cggaagacct
    16381 cgcggtcgag ggcccgctgc ccgtcaccga ccgcctggaa gccctcttcg cgctccgcgt
    16441 gagccacctg ccggaagcca cctgccgcgc tctgctgttg ctcgccgccg ccgacgcggc
    16501 ggacgcgccg gcggccgcac ggggcccgtc cgaggccgac ggcacggcgt gggcacctgc
    16561 cgaacgagcc ggtctcgtac ggcaggacag cgccgggatc tccttccgtc accccgtcgt
    16621 ccgctcggcg gtctaccacg ccgcgtcctt ccgggaacgc aggcaggcgc acctcgccct
    16681 cgcccggctg ctgggcgacg accccgaccg ccgcgcatgg cacctcgccg ccgcgaccgt
    16741 ggggcccgac gaacaggtgt cggcggtgct cctggagacg gcggcccggg cccggcgccg
    16801 gggcggtcac gcggctgccg ccgccgcgct ggaacgcgcc gcggaactca gcccgcgccg
    16861 cgcggaccag gcgcggctgc tggccgacgc ggcggacacg gccgtcttca ccggtcagct
    16921 cggctgggtg gcacacctgg ccgacgaggt gcgcaggcgc agtgacgacc cggcgctgat
    16981 cagccgggcc gcgctggcgg cggggcggct catgatcatg ggtccgcgcc acacggccgc
    17041 cttcgcgctc ctggcgcgca tcgccgacga ggcggcggac gcccggtcgc cccggctgct
    17101 ggacgccctc gccgcggcag cggtggtccg ctactactcg ggcgaggagt cccagcggca
    17161 acggatcgag accctgctcg ccgacctgcc ggacaccgcc acgggtggag cgctgggcac
    17221 ctgggtgcgg gccgtctccg accccgtcgg cgcgggagcg tccctcgccc cggcgctgcc
    17281 gcggctgatc gacgaggcaa agcacgacgc cggaacgctg accgcgctcg ccgtcgtggc
    17341 ctggctgctg gaccggactg ccctggccgc caggaccttc gacgaggcgg ccgaccgttg
    17401 gcgggcccac ggcccgttgc cgaccggtct gggctgcgcc gtcggctgga cctatctgga
    17461 gcagggccgc tgggccgagg cccgctcggt ggccgccgag atcgcggcgg tggccgcgca
    17521 gtccggactg gaccacgccg aggcgtgtgc gcgagcgctc gacgcggcag cggtggcgct
    17581 gctcggtgag ccggccgacg cacgcgagaa cgccgagcgg gccctggccc tcgtcgatcc
    17641 gctggagagc cgctccgtcg cggtcgccgc ccgccgtgcc ctgggcatgg cggcggtggc
    17701 cgagggtgac tacgacaccg cgtacgcgca cttccgctcc gccttcaccg aggacggcga
    17761 cccggtccac taccacgtct cctacaccgt cctggccgaa ctcgccgcgg cggcggcccg
    17821 ccggggacag tgcgcacccg ctgcggaact gctggaacgg tcggtgcgac gcctgggcac
    17881 cggtatgtcg gcacgactcg ccctcctggt cgagcgcgcc cgcgccctgc tggccgaccc
    17941 ggagcacgcc gaacggcact tccgggcggc actcgcgaac gagacgggcg atcagtggcc
    18001 cttcgagcgg gcgcagaccc ggctggacta cggcgagtgg ctgcgcaggc agcgccgtat
    18061 cgcggaggcc cgcccgctgc tgaccggagc actcgacacg ttccggcggc tcggcgcacg
    18121 accgtggatc gaacgcacga aggcggaact gcgcgccgcg ggcatcgagg cgaccggtgc
    18181 cgcacccggt gcgctcaccg aactcagccc ccagcagcaa cagatcgtcc gactcgcggc
    18241 ccgcggcctg acgaaccggg aaatcgggga gaaactgttc ctctccccgc gtacggtcgg
    18301 ctcccacctc taccgggtgt tccccaggct gggcatcacc gcccgcgccc aactgcgcga
    18361 cgtggtcgac gacacgcggc cgcgcccgcc ggaccggcac cgcggagccg gcgcaccggc
    18421 cgcacggtga agcgcactgc cttcgacctg cccctgacct gcgacgaagc cgccccggcc
    18481 ggggttgccg aggcagagaa gacccgccca gccgccggca gcctccgcac cggacagcag
    18541 gccgcacgct atgccccgcc caaggcactc acaggggcca ggcggtcagc aggtcgccgg
    18601 ggccgtaggc ggcatcgagc ccccggcagt cgactccact gcgcgaaacc gccacgacgg
    18661 gaacgggcgc gtcagtgagg gcggcgcggt ggcggtggag agccgccagg tcgtgccggt
    18721 cgaaggacga ctgctccagc cacttgatgg agccgacgaa gagcagttcc ttggcaacgg
    18781 gagcgcgatc cgctcctacg atgtcgattt cgacgtcgtt ggtacgggtc cagtaaccgc
    18841 ccactgcggg ggccgcgggc agccggtcgt cgggcaggat ccgcgccagg gcctcgcgaa
    18901 cgagtggttc gacggcccgg ccacgccaac tggtccagtt ctcccggatc cgcgccaggg
    18961 tcagatcgcc gcgcccccgc tcgatctcct ccatggacgg gccgagcaga tgcagccaga
    19021 accgcaagta gggatctgcg acccggtagc ggcggtcctt cgaggggcgc ggtgacacgg
    19081 gcaactcccc cacgaccacc cgcttttccg cgagcagctc gagagctcgc tgcaacggcg
    19141 tggccccgat accgccggcc gcacgggcga tgttggtgaa ggtccgctcg ccactgccga
    19201 tcgctgccag gaccgtacgc gcctgagcct gcggcgggaa ctcggctgcc agtgagcgct
    19261 cggccgacac cagcagagcc gagaccgggt cactcagcgc ctcgccgagg aagtcccaca
    19321 gtccggcgcc gtgcggccac tccgcgcaga tcagcggcag tccgccggtg acgagcgcgg
    19381 cgtcgaaggc ttccgccgga tcgagcccca gcatccgccc cgcctctgcg gggttgagcg
    19441 gccccagcac catctcccgg ccacgctggt ggaagggccg gccgtagctg ttcagggcct
    19501 ccatcatgga cagatcggag ccgatgagga ccagcagtac cggtttggtc tccagcaccc
    19561 ggtcccacgc ccgttgcagc atcccttcga acgccccgtc ggcgtccatc aggtacggca
    19621 cttcgtcgat gaccagcacg ctcgcccggt cggcgggcag cgccgcggcc agcacgtcga
    19681 aggcggcgtc ccagctcgcc ggccgagcgg cggccaccaa ctgcgccagc ggcagtgtcg
    19741 acgcctgggc gtcgcgggcc agccgcgcca ggtcgtcctc gggggaagca ccggtcgcgg
    19801 catagaacag gaacgggact ccggagcgct ccgcgaaccg ctcgaccagc cgcgacttac
    19861 ccacccggcg ccgcccacgc aacatcacac accgaccggg ccgctcgccg cgcacccctg
    19921 ccgccacctt cgacagctcc cgctccagcg tcgccagctc ctgccgacga cccacgaagt
    19981 ccaccatgcc cggcgacctc cacaacgtga cactaacgac gatgttacta acatagacgt
    20041 tagtaactgc tcctgccgtc gaactgtgga gtttcatatc ggtggatcac cggtttgggt
    20101 tctctgtaca tgggtctccc gcagcgggcg atgcggggcg tgatgccgcg agctcggacc
    20161 catcgacggt ggtggtcgta gtcgtagccc tcgtcgtcgt gcagcttgcc cgatcgcctt
    20221 cggcgcggtc cgcggcggct gcggacgggt gggacggagc agatcagcgg ttgcagggcg
    20281 agctgccgtg ggtgttggcg ccggaggtgc caaccgcgat gggaaaggtc gttgcggtcg
    20341 acgatgaggt ggattttcga tccgcttttg cctcggtcgg tcggattcgg tcccgtcagg
    20401 agccccttcc gggggctcgc acgctgacgg agtcgatcgc gcaccgcgac cagtccagct
    20461 cgccggcgac tccaactcgt cgaggatgac gcggtgcagg cgagcccaga cgtggacctt
    20521 ggaccactgc gcgaagcggc ggtagacggt gggccaggct ggcccgaaca cgggcgacag
    20581 tcgccgccag aagcagccgg aggtggcgac gaagatgatc accgccaggc actcgcaatc
    20641 cccagcccgc cgccacccac cgccctgcgg gtgtaagacc accttcgccg gcatcggccg
    20701 ccgaaacagc tcccacaact cctcaggcac catccgctca gcaaggctcg tcagcccagc
    20761 acaacggcgc aggaccccaa tggaaacgac gcttaagaag cacttcatgt catcccacag
    20821 cagtccagcc accacgctat gttgcccgaa cgccaggcca acaaagcgct gtttcccttt
    20881 gaccaacaac atcctcccgg ccccaacggg taggaatgaa ccacgaaaac gtggatacaa
    20941 acattcctta cacgattgag tgagtcagcg aaagcgaact gcctccttct ctctcctatg
    21001 ccatagttag tcgcggtcgg cggagatcga agggcgagtc atggcagcat ctttggccag
    21061 atcgaacggg acatccgaaa gactttcgcg aatgagcccg tttgcgtgca tatgggagat
    21121 tatcgcgagt gtgacatcaa gcgacatccc acttatccga agtttcgcgc caaggcgatc
    21181 aattccgggg tcca
//
