LOCUS       NZ_WHZR01000001        21059 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. OM5714 A912_AS4_SC1_R2, whole genome shotgun
            sequence.
ACCESSION   NZ_WHZR01000001
VERSION     NZ_WHZR01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. OM5714
  ORGANISM  Streptomyces sp. OM5714
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M.
  TITLE     Whole Genome Sequence of the phthoxazolin producer Streptomyces sp.
            OM5714
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2019) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2017
            Assembly Method                   :: Newbler v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010993835.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:48:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,730
            Genes (coding)                    :: 7,557
            CDSs (with protein)               :: 7,557
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 7, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 7, 5 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 58 of 173
            Pseudo Genes (incomplete)         :: 139 of 173
            Pseudo Genes (internal stop)      :: 18 of 173
            Pseudo Genes (multiple problems)  :: 36 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:03:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2833870
            Orig. end                         :: 2854929
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHZR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21059
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="18"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21059
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21059
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11059](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11059
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(124..1251)
                     /locus_tag="STPH1_RS12125"
                     /old_locus_tag="STPH1_2424"
     CDS             complement(124..1251)
                     /EC_number="7.4.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0015833 - peptide transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327064.1"
                     /locus_tag="STPH1_RS12125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2424"
                     /product="dipeptide ABC transporter ATP-binding protein"
                     /protein_id="WP_164383346.1"
                     /transl_table=11
                     /translation="MAETTEPILEVRGLVKHYPLTSGILFKKQVGAVKAVDGVDFELAR
                     GETLGIVGESGCGKSTVAKMLVNLERPTAGEIRYKGEDITRLSGRALKSVRRNIQMVFQ
                     DPYTSLNPRMTVGDIIGEAYDIHPEVAPKGDRRKRVQDLLDVVGLNPEYINRYPHQFSG
                     GQRQRIGIARGLALRPEIIVADEPVSALDVSVQAQVINLMGRLQDEFDLSYIFIAHDLS
                     IVRHISDRVGVMYLGRIVETGRDAEIYDHPTHPYTQALLSAVPVPDPEAREHRERIILA
                     GDVPSPTNIPSGCRFRTRCWKARERCALEVPLLAVPAEFRDVSGPAAHDSACHFAEEKQ
                     VVPPEEPGPSGPHGAGGPPGSRGPHGSHREDSEGG"
     gene            complement(1244..2227)
                     /locus_tag="STPH1_RS12130"
                     /old_locus_tag="STPH1_2425"
     CDS             complement(1244..2227)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030066.1"
                     /locus_tag="STPH1_RS12130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2425"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_153178100.1"
                     /transl_table=11
                     /translation="MLLEVRDLHVEFRTRDGVAKAVNGVSYGVDAGETLAVLGESGSGK
                     SVTAQTIMGILDIPPGRVTAGEILFEGRDLLKLKEEERRKVRGAEMAMIFQDALSSLNP
                     VLTVGAQLAEMFTVHRGMSRKDAHAKAVELMDRVRIPAARERVRQYPHQFSGGMRQRIM
                     IAMAMALEPKLIIADEPTTALDVTVQAQVMDLLAELQRELHMGLILITHDLGVVADVAD
                     KIAVMYAGRIVETAPVHDIYKAPAHPYTRGLLESIPRLDQKGQELYAIKGLPPNLTRIP
                     PGCAFHPRCPMAQDVCRTDVPPLYDVTESDAERGSACHFWRECLHG"
     gene            complement(2236..3216)
                     /locus_tag="STPH1_RS12135"
                     /old_locus_tag="STPH1_2426"
     CDS             complement(2236..3216)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973858.1"
                     /locus_tag="STPH1_RS12135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2426"
                     /product="ABC transporter permease"
                     /protein_id="WP_164383347.1"
                     /transl_table=11
                     /translation="MPEQEPYEPERAIAGTGMGGTMDLGTSEAVTLEQPPGPDGADPRE
                     KPRSLWSDAWHDLRRNPVFIISALVILFLVVISIWPSLIASGSPLKCDLAKAQEGSQPG
                     HPFGFNGQGCDVYTRTVYGARTSVAVGILATLGVAILGSVLGGLAGFFGGGGDAVLSRI
                     TDIFFAIPVVLGGLVLLSVITSNTIWPVIGFIVLLGWPQISRIARGSVITAKQNDYVQA
                     ARALGASNSRLLLRHIAPNAIAPVIVVATIALGTYISLEATLSFLGVGLKPPSVSWGID
                     ISSAAPYVRNAPHALLWPSGALAITVLAFIMLGDAVRDALDPKLR"
     gene            complement(3209..4132)
                     /locus_tag="STPH1_RS12140"
                     /old_locus_tag="STPH1_2427"
     CDS             complement(3209..4132)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550237.1"
                     /locus_tag="STPH1_RS12140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2427"
                     /product="ABC transporter permease"
                     /protein_id="WP_164383348.1"
                     /transl_table=11
                     /translation="MGRYVVRRLLQMIPVFIGATLLIFLMVNVMGDPIAGLCGDRECDP
                     ATAAQLRHEFGLDQPVWRQYATYMGNVFTGDFGTAFNGQPVTELMGTAFPVTIRLTIVA
                     ILFEIVVGIILGVVTGLRRGRPVDTGVLLLTLVVISVPTFVTGLLLQLLLGVKWGWIDP
                     AVSSEALFGELIVPGLVLASVSLAYVTRLTRTSIAENRRSDYVRTAIAKGLPRHRVITR
                     HLLRNSLIPVVTFIGTDIGALMGGAIVTERIFNIHGVGYQLYQGILRQNTQTVVGFVTV
                     LVLVFLVANLVVDLLYAVLDPRIRYA"
     gene            complement(4142..5776)
                     /locus_tag="STPH1_RS12145"
                     /old_locus_tag="STPH1_2428"
     CDS             complement(4142..5776)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444498.1"
                     /locus_tag="STPH1_RS12145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2428"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_164383349.1"
                     /transl_table=11
                     /translation="MRGATHAKWAACAAAVVLAATACGGGGGDGGSGGDGGGVLSSSWG
                     DPQNPLEPANTNEVQGGKVLDMIFRGLKKYDPDTGEAKNMLAEKIETSDSQNFTVTVKD
                     GWTFSNGEKVTAQSFVDAWNYGASLKNNQRNAYFFAYIDGYDKVHPESGSQSADTLSGL
                     KVTGPRTFTIKLNQKFSSFPDTLGYAAFAPLPKAFFDDHDAWLKKPVGNGPYQVDNYTR
                     GSQMSLRKWDDYPGPDKAQNGGVDLKVYTDNNTAYTDLIAGNLDLVDDVPASQLKNVKN
                     DLGDRYINTPAGIIQTLAFPFYDNDWSKSGSEKVRKGLSMAINRKQITDTIFQQTRTPA
                     TDWTSPVLGKDGGYKPGLCGDACEYNPEEAKKLVKEGGGLPGGQVKITYNADTGSHKQW
                     VDAVCNSINNALDNDRACAGNPVGTFADFRNQITDQKMSGPFRAGWQMDYPLIQNFLQP
                     LYYTNASSNDGKWSNQKFDDLVDKANAETDTAKAVGLFQQAEEVLRDDMGAIPLWYQNG
                     SAGYSDRLSDVKLNPFSVPVYNEIKVG"
     gene            6032..6196
                     /locus_tag="STPH1_RS12150"
                     /old_locus_tag="STPH1_2429"
     CDS             6032..6196
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="STPH1_RS12150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="STPH1_2429"
                     /product="hypothetical protein"
                     /protein_id="WP_153178103.1"
                     /transl_table=11
                     /translation="MSKMLSRIADKLLPQTSAAAGCAPGCWMERSSTGGQFYEYKCCYN
                     PNCSVRCFV"
     gene            6274..6789
                     /locus_tag="STPH1_RS12155"
                     /old_locus_tag="STPH1_2430"
     CDS             6274..6789
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="STPH1_RS12155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2430"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_153178104.1"
                     /transl_table=11
                     /translation="MAVAFGQLCLATVLFWSGLLKLRDVSAFRRHVATTLPRLGGGLSA
                     ALALAVPAVEVAAAGLLLIRPWAWLGCAAATLLLLAFTGYLIGLMRSRPDASCGCAGAD
                     DTPVSEVHVLRNVLLLTVCVLTWWATVRTGGPGPVAYAVVVAPAAVFGVALLHLGELVS
                     FFRPPRTT"
     gene            6804..7379
                     /locus_tag="STPH1_RS12160"
                     /old_locus_tag="STPH1_2431"
     CDS             6804..7379
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="STPH1_RS12160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="STPH1_2431"
                     /product="hypothetical protein"
                     /protein_id="WP_153178105.1"
                     /transl_table=11
                     /translation="MSIALAVLALLVASAACGLSVAVALRVKKLLDPLTQEGALSRRPD
                     ELPAVGTLVPPVPGLLDMDGNEVRLPVPGSRPWILSFQSVGCSGCEQQLPGYAKFLRDA
                     GVDRDRVVSFVVGDPDGAALYRDQLGELAHVVAGEKQAPTLIGELGVSMFPTYLVVDGE
                     GRVTVSSGSSARLAGSVPELSSSALARS"
     gene            7385..9244
                     /locus_tag="STPH1_RS12165"
                     /old_locus_tag="STPH1_2432"
     CDS             7385..9244
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018486997.1"
                     /locus_tag="STPH1_RS12165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2432"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_164383350.1"
                     /transl_table=11
                     /translation="MIRQGLAPVLGVLSLAREAAALKLAAYAALDLLSGAFPVAAGWLT
                     KLALDELGAQAPVNTLVALAVGLALVGVVQAVVPHVSGYLQAEVERATGTLAQGRLFTA
                     VGRFVGIGPFEDPSFLDKLRLAKQSGKSAPGQVVGGVLGTVRAGVTIVGFLSSLLVIAP
                     LMALFVLVFAVPVLVAEIVLSRRRADMIWRISPRERREFFFDQLLSNVEAAKEVRLFGI
                     GGFLLGRMQTERLASNAARRAVDRRELSTQSLLALFAALVSGTGLVWAIHSALSGGLTL
                     GDVAIFIAAVAGVQSSVGQLSAGAAQAHQALVLFGHYQDVVATEPDLARAADPLPAPAL
                     AHGLELRDVWFRYGPDQPWVLRGVDLFIPKGRSTALVGLNGAGKSTLVKLLCRFYDPTR
                     GAILWDGVDIREFDPDDLRRRTSAVFQDFMHYDLTARENIALGDLDALASSSRVAEAAR
                     NAGIDRTLEGLPRGYDTLVTRTFFPGEEQDDTTTGVLLSGGQMQRLALARALVREQRDF
                     LILDEPTSGLDAEAEHELHTRLSEFHHGRTSLLISHRLGSVREADVIVVLSEGRITERG
                     DHATLMALDGSYARLFGLQAAGYAGGSPSLPEHGPAAVEGAVP"
     gene            9244..9690
                     /gene="lepB"
                     /locus_tag="STPH1_RS12170"
                     /old_locus_tag="STPH1_2433"
     CDS             9244..9690
                     /EC_number="3.4.21.89"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006465 - signal peptide processing
                     [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="lepB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979298.1"
                     /locus_tag="STPH1_RS12170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2433"
                     /product="signal peptidase I"
                     /protein_id="WP_164386333.1"
                     /transl_table=11
                     /translation="MWAVAGGCAGLVVAGTALLRRRLVSVTVTGHSMLPAYRPGDRVLV
                     RRGAVPRRGQVVVVELPDTERRSWISEPAGLGSPGTPVTERQWLLKRVSAVAGDPCGSR
                     DEAAGRVPPGHLLLLGDNASVSFDSRQMGPFPVERVLGAVWRRL"
     gene            9780..9920
                     /locus_tag="STPH1_RS12175"
                     /old_locus_tag="STPH1_2434"
     CDS             9780..9920
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="STPH1_RS12175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="STPH1_2434"
                     /product="hypothetical protein"
                     /protein_id="WP_153178107.1"
                     /transl_table=11
                     /translation="MQDNTRGTQDDERAFPVVTEPEGQTELIEIRMLDKIETIDSKAVA
                     R"
     gene            10001..11059
                     /locus_tag="STPH1_RS12180"
                     /old_locus_tag="STPH1_2435"
     CDS             10001..11059
                     /GO_function="GO:0008641 - ubiquitin-like modifier
                     activating enzyme activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444474.1"
                     /locus_tag="STPH1_RS12180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2435"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_240469003.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 1.8e-11,
                     bitscore: 42.6, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 1.8e-41, bitscore: 140.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKREHIPHRFDDGTVRLGGEVYGIAAEITDRHGWAWDALTLMDGT
                     APRQDIETALAERHPRLGADGARRLVRELIGTGYVEDAAAGRPDGFTDGEIERYSRNHD
                     YFRRVDLRPGSDPWEAQRRIGRARVTVLGVGGTGSHAAWALTAVGVGTLHLVDPDRVEV
                     SNLTRQTLYTEADVGRAKAEVAAERIGAVNSSGRFTCDVRRVDTEDALRELVAGCDVFV
                     LCADEPRNDVINKMTNRVCAGLGVPWVTAGYNGPLVTVGVYGPEGPCFECVGAGEEAKL
                     KPGRHPDLGGTGAMAPAAGISGQLIANEVVSLVTGTARTPPGFVRGINLIAPDHLVHVR
                     HPARPECPLCSR"
     aSDomain        10004..10255
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_STPH1_RS12180_Pantocin_Microcin_RRE.1
                     "
                     /evalue="7.30E-14"
                     /identifier="RREFam017.1"
                     /label="STPH1_RS12180"
                     /locus_tag="STPH1_RS12180"
                     /protein_end="85"
                     /protein_start="1"
                     /score="42.6"
                     /tool="antismash"
                     /translation="KREHIPHRFDDGTVRLGGEVYGIAAEITDRHGWAWDALTLMDGTA
                     PRQDIETALAERHPRLGADGARRLVRELIGTGYVEDAAA"
     gene            11047..12264
                     /locus_tag="STPH1_RS12185"
                     /old_locus_tag="STPH1_2436"
     CDS             11047..12264
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444473.1"
                     /locus_tag="STPH1_RS12185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2436"
                     /product="hypothetical protein"
                     /protein_id="WP_164383352.1"
                     /transl_table=11
                     /translation="MQPVTRTGGLDVSFHELEFRPDRDEWIVGRQGTDEIVALPGIGMD
                     AIRLLSAGRTVEETRSSLRASTGRDVDVRAFVERLASAGLVASIGERRFPVAPAAVSFP
                     RVRPHQVRLLLNPVLHAVLLLVPVAGLAVALTRPGTFPSWDSFLWTEYGTFTVLVQCVI
                     GWCLIALHEAAHLLTARATGVRGRIRLGTRLQFLVAQTEVSGIWLKGRRARLTVYLSGI
                     VLDAVIWGGCLLARAWGADFVLLPVVVATLFLALANQCLVFMRTDLYFVVQDLTGCRNL
                     FTDTTRYLRHVAALPFGRRAPHPLRSLPARERRFVKGYAVAVAVGSVVCLAIGLRVLTE
                     VTWPLLRRSLVHMVDGSDWWLRLDALATVLVLCGMQTLWARLWWKRHGDRVGRAGRAAR
                     RWRRDR"
     gene            12312..15728
                     /locus_tag="STPH1_RS12190"
                     /old_locus_tag="STPH1_2437"
     CDS             12312..15728
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444472.1"
                     /locus_tag="STPH1_RS12190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2437"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_164383353.1"
                     /transl_table=11
                     /translation="MHNRSPRFRLLGPLEIRVDDTAVVLTGRQRALCAVLLLHADRVVS
                     VDRLAQGLWDERMPSASAARIRALVSEVRHAFGPDGAALLATRKPGYVLRAAPAEVDAF
                     LFEALIRDGLRALAHKEWAEAYRYHDDALALWRGDPLPDLPAMEAERRRLTELRIAAEE
                     GRAEAELELGRPRSAVADLVRLTSEHPLRERPHALLMRSLARDGRSPDALAVYTGLRNR
                     MVRELGVDPSDELTELHRRLLVGDAAPRAAGSAPAEPSRHRWVPRQLPRAPHRFVGRNT
                     ELRLLDVCPREDGAPAVIVGPAGAGKTALALHWAHRIADGYPDGQLFLDMRGFDNAGPM
                     SLEEALPLLLQGLGCAPHDIPLGLDAQTALYRTLLAGRRVLVVLDDVADASTVRRLLPS
                     TSGSLTLVTSRRKLNGLVLDGAHRVTCDVLSREEALELFGAAIGADAVAADPGAAAHLV
                     ELCDHLPLALCVAGSWIGTGAGSVRAYVTSLAERGRLARLHVEGEESVAVRAALDLSYG
                     TLPDEAKWVFRSLGLIPGTGRSVAATAAGAGLDESHTADLLRLAQRVHLLRDTEDGRTA
                     WHDLVHEYAVERVVTEDAEAERARAVDRLLDHYLQSVSRVAETCRLYCPQPRPEPVGGS
                     VPRTFRTPEEAFAWFDEEWEDIAAAIAYAAEHGPARFAWQIVDALQDLFHHRRPLSDWL
                     RLAALAGKAAERGGDRRGQAVVHLSSGHALWRSGDFRGALGAYESAQLAARDAGWLSGE
                     ARSAQGTGVTLKLLGEPREALPFYDRALTLYRTLGMTEAEKIMLTNTASLQLALGRLAE
                     AEEAVTAALALDAGTQGHLHSMTLVNHALVQQKQARFRDAAATLRKGLEVSRASESLYA
                     EAVMLETLGRVRDDAGQDARALLAYEDALGLARRVGNRNCQVDSLVGLASLELRTGRTR
                     EAAAHLDDARTIAEETGHRTGLIEILLVRGALHCAEGRYREAAAVLETAGGLAVNGSPL
                     TLPRIRSPSAVALRKTGETTAATEAAREAVEQARHSGQRLVLARALTALAAAHEAPGDV
                     RSPAGYRDEAETLFDAIGVPSSCRTATGRRTATGHRGADAAPDRSPAARIPAARSARPP
                     LPDDAAERLARYLADHFDDLTDDGPGTGGRL"
     gene            complement(15723..16514)
                     /locus_tag="STPH1_RS12195"
                     /old_locus_tag="STPH1_2438"
     CDS             complement(15723..16514)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444494.1"
                     /locus_tag="STPH1_RS12195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2438"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_205616670.1"
                     /transl_table=11
                     /translation="MNVQILGCIELRATDGGNIPVSPTVGRLLATLAWSANSFITDEDT
                     IGRVWESRVPAHPRDALYTVATRLRKALHAVAAPDTACDVVRRPGGYTLVAAEETVDVL
                     RFRALVRQARNAQCRGEEEAALERYERALALCHGRPLSDVRTAWAEAARVTFGQELRAA
                     RINSAELALGLGRCDDYVPLLHELAEAHPLDERIASLLMLALYRSGRQDEALRCFRSIR
                     SRFVAELGVEPGGRLRMLHERILRRDEIVHGGRPVWAAMAS"
     misc_feature    complement(16558..16570)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    16751..16766
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.61"
                     /tool="antismash"
     misc_feature    16867..16882
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.93"
                     /tool="antismash"
     misc_feature    complement(16893..16906)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.14"
                     /tool="antismash"
     gene            16972..18000
                     /locus_tag="STPH1_RS12200"
                     /old_locus_tag="STPH1_2439"
     CDS             16972..18000
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444470.1"
                     /locus_tag="STPH1_RS12200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2439"
                     /product="ABC transporter permease"
                     /protein_id="WP_207627886.1"
                     /transl_table=11
                     /translation="MTPPTPSAAAPLEVTDETVDKSPMPATPKGSESRSPGRLAWKRFK
                     RDRTGVISACIVIFFFAIALAAPLIAKLYGKDPYTTYASQRPELLDAFSYPAGPNGGMS
                     SEFWFGIEPQLGRDVFTFLLYGIRTSLGLAVAATIVTAVLGVVIGTTAGYLGGKTDYLV
                     GRIIDILLSFPSTLFFIAFMPVIYGLFVAPDENIPTSLRAISLIIVLSGFGWASLARLL
                     RGQVLGLREREFVEAAKVTGASPWRIVFKELLPNLWTPIIIQTTLMLPMFVTAEAGLAF
                     LGVGMIDPTPDWGVMIQRGAQFYTEDLTFMLFPGLSMVIFVLAFNLLGDSVRDALDPKT
                     KR"
     gene            18079..19842
                     /locus_tag="STPH1_RS12205"
                     /old_locus_tag="STPH1_2440"
     CDS             18079..19842
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444469.1"
                     /locus_tag="STPH1_RS12205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2440"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_164383354.1"
                     /transl_table=11
                     /translation="MAFSRRNFLIATGVVAASSSVLTACGGSDNKGGGGKSDAPKVSGS
                     KTVEILVGTKADSTGPAPEVKGAVKGGIVHSLDQFDMDHMDPAQIYVSTEGAITVPIMR
                     GLTGYKLDDKGGCTLVGDVATDAGTMKDGGKTWSFTIKDGVKWEDGSDLSMDDVRHTFE
                     RLFADFVTEGPRYVQQFLVGGDKYKGPYDGKQLDSVEVDGKTITFRLNEPRADFNFTLA
                     MRGYSLVPKAKDTKQKYDSRPFSCGPYKISERSVGKSLTYVRNEHWDPKTDAIRNAYPD
                     QYQFRFGYQPLAATDRFIADSGEDQQAMAIFNEVAPERIAKVLTDPNLKKRVLTAVDTV
                     TYYWPINTTRIKDVKVRQAINWAWPHQQLQTIRGGASTSELATTILSPVTPGHEEFDLY
                     GVDKKPGGDPEKAKALLKEAGKVGQKLVIAYQTSDNALKQAVAIKNALEAAGFKVVNKQ
                     LDKSTFYTQIGKIDNGYDLFAAGWSPDWPNGYSVFYPCWSGENIGNGRSNYAQLDDPSV
                     NKAINAASKIADAEEANKAWGAIDRQIMELAAVVPDYHSIRNWMYGSKIGNVVFDYGNT
                     CIALCKLYVKK"
     gene            19947..20927
                     /locus_tag="STPH1_RS12210"
                     /old_locus_tag="STPH1_2441"
     CDS             19947..20927
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444468.1"
                     /locus_tag="STPH1_RS12210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_2441"
                     /product="ABC transporter permease"
                     /protein_id="WP_164383355.1"
                     /transl_table=11
                     /translation="MFRFLVRRVFGALVILLIISAITFWLFYAVPRDPAMMSCGKNCTP
                     ENLEQIRKNLGIDESIVMQYWHWLSGIFAGRDYAGYGNCEAPCLGYSFANNQPVYGTIM
                     DRLPLTLSLAFGAAIFFLIIGIGAGMLAASKQGKFLDKFASSVSLLGSSLQIYFVGYIA
                     MFFLVGELGILSQPSYTPLTDDPAAWVSGLLLPWLVLSIIFTANYTRMTRSQMVEQLSE
                     DYVRTARAKGLSKRNVFFRFAWRGAMGPIVTIFGVDLGVLIGGAIITETTFSLQGIGRL
                     AIESVFKSDLPMLLGVTVLAAGAIVLFNIVVDAVYALIDPRIRLA"
     misc_feature    19989..20003
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.6"
                     /tool="antismash"
ORIGIN
        1 gccctggtcg aggcgatcga gacggccacg gggaaggtgg tcgtcactga agacggatat
       61 cccgcaaccg gtgtggtgga cgagggcgac gaagactgaa cctccgcggg ccgccccgtc
      121 gtgtcatccg ccttcgctgt cctcccggtg cgagccgtgc ggtccgcgcg aaccgggcgg
      181 tccgcccgct ccatgcggcc cggacggtcc cggctcctcc ggcggtacca cctgcttctc
      241 ctccgcgaag tggcacgccg agtcgtgggc cgcggggccg gagacgtccc ggaactcggc
      301 ggggaccgcc aggagcggta cctcgagggc gcagcgctcc cgtgccttcc agcagcgggt
      361 gcggaagcgg cagccggagg ggatgttggt cggggacggg acgtcgccgg ccaggatgat
      421 ccgctcgcgg tgctcccggg cctccgggtc gggcaccggc acggcggaca gcagggcctg
      481 ggtgtagggg tgggtcggat ggtcgtagat ctccgcgtcg cggcccgtct ccacgatgcg
      541 gcccaggtac atcacgccga cccggtccga gatgtgccgg acgatcgaga ggtcgtgggc
      601 gatgaagatg taggagaggt cgaactcgtc ctggaggcgg cccatcaggt tgatcacctg
      661 ggcctggacc gagacgtcga gggcggagac cggctcgtcc gcgacgatga tctccgggcg
      721 cagcgccagg ccccgcgcga tgccgatgcg ctggcgctgg ccgccggaga actggtgggg
      781 gtagcggttg atgtactccg ggttcaggcc gaccacgtcc agcaggtcct ggacccgctt
      841 ccggcggtcg cccttggggg ccacctcggg gtggatgtcg tacgcctcgc cgatgatgtc
      901 gccgacggtc atgcgggggt tgagggaggt gtaggggtcc tggaagacca tctggatgtt
      961 gcggcgtacg gacttcaggg ccctgcccga gaggcgggtg atgtcctcgc ccttgtagcg
     1021 gatctcgccg gccgtcggcc gttccaggtt gaccagcatc ttggcgaccg tggacttgcc
     1081 gcagccggac tcgccgacga tgccgagggt ctcgccgcgg gccagctcga agtccacgcc
     1141 gtcgacggcc ttgaccgcgc cgacctgctt cttgaagagg atgccggagg tcagcgggta
     1201 gtgcttgacc aggccgcgga cttcgaggat cggctcggtg gtctcagcca tgcaggcact
     1261 ccctccagaa gtggcaggcg ctgccccgct cggcgtcgga ctcggtcacg tcgtacaggg
     1321 gcggtacgtc ggtgcggcag acgtcctggg ccatcgggca gcgggggtgg aaggcgcagc
     1381 cgggcgggat gcgggtgagg ttgggcggca ggcccttgat ggcgtagagc tcctggccct
     1441 tctggtcgag gcgcgggatg gattccagga ggccgcgggt gtacgggtgg gcgggcgcct
     1501 tgtagatgtc gtggaccggg gccgtctcca cgatccggcc cgcgtacatg accgcgatct
     1561 tgtcggcgac gtcggcgacc acgccgaggt cgtgggtgat gaggatgagc cccatgtgca
     1621 gctcgcgctg gagttccgcg agcaggtcca tgacctgggc ctggacggtg acgtcgaggg
     1681 cggtggtcgg ttcgtcggcg atgatcagct tgggttccag ggccatcgcc atggcgatca
     1741 tgatgcgctg gcgcatgccg ccggagaact ggtgcgggta ctgccgcacc cgctccctgg
     1801 cggccgggat gcgcacccgg tccatcagct cgacggcctt ggcgtgggcg tccttgcggg
     1861 acatgccgcg gtgcacggtg aacatctcgg cgagctgggc accgacggtc aggacggggt
     1921 tcagcgagga cagcgcgtcc tggaagatca tcgccatctc ggcgccgcgg accttccggc
     1981 gttcctcctc cttcagcttc agcaggtccc ggccctcgaa gaggatctcc cccgcggtga
     2041 ccctgcccgg cgggatgtcg aggatgccca tgatcgtctg ggcggtgacg gacttgccgg
     2101 agccggactc gccgagcacc gcgagggtct cgcccgcgtc cacgccgtag ctgacgccgt
     2161 tgacggcctt ggcgacgccg tcccgggtgc ggaactccac gtgcaggtcg cgtacttcga
     2221 gcagcatgcg gtcgctcacc tcagcttcgg gtcgagggcg tcgcgcaccg cgtcgccgag
     2281 catgatgaac gcgaggacgg tgatggcgag ggctccggag ggccagagca gcgcgtgcgg
     2341 ggcgttgcgc acgtaggggg cggcggagga gatgtcgatg ccccaggaga cgctgggcgg
     2401 cttgagaccg acgccgagga aggacagggt cgcctccagg gagatgtagg tgccgagtgc
     2461 gatggtcgcc acgacgatga cgggcgcgat cgcgttgggc gcgatgtggc ggagcaggag
     2521 acgggagttg gaggcgccca gggcacgggc cgcctggacg tagtcgttct gcttggcggt
     2581 gatgacggag ccgcgggcga tgcgggagat ctgcggccag ccgagcagca cgatgaagcc
     2641 gatgaccggc cagatggtgt tgctggtgat gacggagagc aggacgaggc cgcccaggac
     2701 gaccgggatc gcgaagaaga tgtcggtgat ccgggacagg accgcgtccc cgccgccgcc
     2761 gaagaacccg gcgaggccgc cgaggacgct gccgaggatc gcgacgccga gcgtggcgag
     2821 gatgccgacc gcgaccgagg tgcgggcgcc gtagacggtg cgggtgtaga cgtcgcagcc
     2881 ctggccgttg aagccgaagg ggtggccggg ctgggagccc tcctgggcct tggccaggtc
     2941 gcacttgagg gggctgccgg aggcgatcag ggacggccag atggagatga cgaccaggaa
     3001 gaggatcacc agggccgaga tgatgaagac ggggttgcgg cgcaggtcgt gccaggcgtc
     3061 ggaccagagg ctgcgcggtt tctcgcgggg gtcggcgccg tccggtccgg gcggctgctc
     3121 cagcgtgacc gcctcgctgg tgccgaggtc catcgtgccg cccatgccgg tgccggcgat
     3181 ggcgcgttcg ggctcgtagg gctcctgttc aggcatagcg gatcctcggg tcgagtacgg
     3241 cgtacaggag gtcgacgacg aggttggcga cgaggaagac gaggaccagg acggtgacga
     3301 agccgaccac ggtctgggtg ttctggcgca ggatgccctg gtagagctgg tagccgacgc
     3361 cgtggatgtt gaagatccgc tcggtgacga tggcgccgcc catcagggcg ccgatgtcgg
     3421 tgccgatgaa ggtgacgacc gggatgaggg agttgcgcag caggtgccgg gtgatgaccc
     3481 ggtgccgggg caggcccttg gcgatggcgg tgcggacgta gtcggagcgc cggttctccg
     3541 cgatggaggt gcgggtcagc cgggtgacgt aggccagcga gaccgaggcg agcaccaggc
     3601 cggggacgat cagctcgccg aagagcgcct cggaggagac cgccgggtcg atccagcccc
     3661 acttgacgcc gagcagcagc tggagcagca ggccggtgac gaaggtgggg acggagatga
     3721 cgacgagggt gaggagcagc accccggtgt cgacggggcg gccgcggcgc aggccggtga
     3781 cgacgccgag gatgatcccc acgacgatct cgaagaggat cgcgacgatg gtcagccgga
     3841 tggtgaccgg gaacgccgtg cccatcagct cggtgaccgg ctggccgttg aaggcggtgc
     3901 cgaagtcgcc ggtgaagacg ttgcccatgt aggtggcgta ctgccgccac acgggctggt
     3961 cgaggccgaa ctcgtgccgc agctgcgcgg ccgtcgccgg atcgcactcc cggtcgccgc
     4021 acaggcccgc gatggggtcg cccatcacgt tgaccatcag gaagatcagc agcgtggccc
     4081 cgatgaagac cgggatcatc tggagcagcc gccggacgac gtagcgtccc atggcgcccc
     4141 ctcagccgac cttgatctcg ttgtagaccg ggacgctgaa ggggttgagc ttgacgtcgg
     4201 agagccggtc ggagtagccg gcgctgccgt tctggtacca gagcgggatg gcgcccatgt
     4261 cgtccctgag gacttcctcg gcctgctgga agaggccgac ggccttggcg gtgtcggtct
     4321 cggcgttggc cttgtcgacg aggtcgtcga acttctggtt ggaccacttg ccgtcgttgg
     4381 aggaggcgtt ggtgtagtag agcggctgga ggaagttctg gatgagcggg tagtccatct
     4441 gccagccggc gcggaagggg ccgctcatct tctggtcggt gatctggttg cggaagtcgg
     4501 cgaaggtgcc gaccgggttg ccggcgcagg cgcggtcgtt gtccagggcg ttgttgatgg
     4561 agttgcagac cgcgtcgacc cactgcttgt gggagccggt gtcggcgttg tacgtgatct
     4621 tgacctggcc tccgggcagc ccgccgccct ccttgaccag cttcttggct tcctcggggt
     4681 tgtactcgca ggcgtcgccg cacaggcccg gcttgtagcc gccgtccttg ccgaggaccg
     4741 gtgaggtcca gtcggtggcc ggggtgcggg tctgctggaa gatcgtgtcg gtgatctgct
     4801 tgcggttgat cgccatggac aggcccttgc ggaccttctc ggagccggac ttgctccagt
     4861 cgttgtcgta gaacgggaag gcgagcgtct ggatgatgcc ggcgggggtg ttgatgtacc
     4921 ggtcgccgag gtcgttcttg acgttcttga gctgggacgc cgggacgtcg tcgaccaggt
     4981 cgaggttgcc ggcgatcagg tccgtgtagg cggtgttgtt gtcggtgtag accttgaggt
     5041 ccacgccgcc gttctgcgcc ttgtccgggc cggggtagtc gtcccacttg cgcagggaca
     5101 tctgcgagcc gcgcgtgtag ttgtcgacct ggtacgggcc gttgccgacc ggcttcttca
     5161 gccaggcgtc gtggtcgtcg aagaacgcct tgggcagcgg cgcgaaggcg gcgtagccga
     5221 gggtgtcggg gaagctggag aacttctggt tgagcttgat ggtgaaggtg cgcgggccgg
     5281 tcaccttcag cccggagagc gtgtcggcgc tctgcgagcc gctctcgggg tgcaccttgt
     5341 cgtagccgtc gatgtacgcg aagaagtagg cgttgcgctg gttgttcttc aggctcgcgc
     5401 cgtagttcca ggcgtccacg aaggactggg cggtgacctt ctcgccgttg ctgaaggtcc
     5461 agccgtcctt gacggtgacg gtgaagttct gcgagtcgga ggtctcgatc ttctcggcga
     5521 gcatgttctt ggcctcgccg gtgtcggggt cgtacttctt cagcccccgg aagatcatgt
     5581 cgaggacctt gccgccctgc acctcgttgg tgttggcggg ctccagcggg ttctgcgggt
     5641 cgccccagga ggagctgagc actccgccgc cgtccccgcc actgccgccg tccccgcccc
     5701 cgccgccgca ggccgtcgcc gcgaggacta ccgccgccgc gcaagcggcc catttggcgt
     5761 gcgtggctcc gcgcatggag tgcctcctcg tgccctgact cgtcctttgc cccatttcag
     5821 tcaatatccg tggatcaccg acactccgca ccttcagtcc caccatccgg ggtgccccgc
     5881 gaccggaggg cagccgtcca ccggctccgc cgcccgctca ccgcgccgga aaggccactg
     5941 aaagacgacg gaaagtccgc cggtggagcc tggggaccga ggccgggcgc ccgcctgacg
     6001 ccccgacgga gaacacgacg aggagaactc catgtccaag atgctgagcc gtatcgccga
     6061 caagctgctg ccccagacgt ccgccgccgc cggctgcgca ccgggctgct ggatggagcg
     6121 cagcagcacg ggtggccagt tctacgagta caagtgctgc tacaacccga actgctcggt
     6181 gcgctgcttc gtctgagacc cgtggccgcc gtgcccgaac gggtgcacgg cggccatcgg
     6241 ccaccgatcc acctctagcg ggaatggaca gacatggcag tagcattcgg ccagttgtgt
     6301 ctggccaccg tgctcttctg gtcgggcctg ctcaaactcc gggacgtctc cgcctttcgc
     6361 cggcacgtcg ccaccaccct gccgcggctg gggggcggcc tttcggcagc cctggccctc
     6421 gcggtccccg ccgtcgaggt ggccgccgcg ggacttctgc tgatccggcc gtgggcctgg
     6481 ctcgggtgtg ccgcggccac gttgctgctg ctggccttca ccggatatct gatcggcctg
     6541 atgcggtcgc gcccggacgc gtcctgcggc tgcgccggag cggacgacac gcccgtctcc
     6601 gaagtgcacg tcctgcgcaa cgtcctgctc ctgaccgtct gcgtcctcac ctggtgggcg
     6661 accgtgcgca ccggcggtcc cggcccggtc gcctacgccg tcgtcgtggc acccgccgcg
     6721 gtcttcggcg tcgccctgct ccacctcggg gaactggtct ccttcttccg ccccccgcgc
     6781 acgacctgag aactggagtc cctatgagca tcgcgctcgc cgtcctcgcc ctgctggtcg
     6841 cttccgccgc gtgcggtctc tccgtggccg tcgcgctgcg cgtcaagaag ctcctcgatc
     6901 cgctgaccca ggagggagcg ctgagtcgcc gtccggacga gctccccgcc gtgggcaccc
     6961 tcgtcccgcc ggtgcccgga ctcctcgaca tggacgggaa cgaggtacgg ctgcccgttc
     7021 ccggctcgcg gccgtggatc ctctccttcc agtcggtcgg atgcagcggc tgtgaacagc
     7081 agctgccggg atacgcgaag ttcctgcgcg acgcgggtgt cgaccgggac cgcgtcgtct
     7141 ccttcgtcgt cggggacccg gacggagccg ccctctaccg ggaccagctc ggcgaactgg
     7201 cccacgtcgt cgccggggag aagcaggcac ccacgctgat cggcgagttg ggggtgtcga
     7261 tgttccccac gtacctcgtg gtggacggag agggcagggt gacggtgtcg tccggcagtt
     7321 cggcccggct cgccggcagc gtccccgagc tgtcctcgtc ggccctcgcc aggagttaat
     7381 gctcatgatc agacaagggc tcgccccggt cctgggcgtt ctctccctcg cacgcgaggc
     7441 cgccgcgctc aagctggccg cctatgccgc gctcgacctg ctcagcgggg ccttcccggt
     7501 cgccgccggc tggctcacca agctcgccct cgacgagctg ggcgcccagg caccggtgaa
     7561 caccctggtg gcgctggccg tcggactggc cctcgtcggc gtcgtccagg ccgtggtccc
     7621 gcacgtctcc ggctatctgc aggcggaggt cgagcgggcc accggaaccc tggcgcaggg
     7681 gcggctgttc accgcggtgg gccggttcgt cggcatcggg cccttcgagg acccgagctt
     7741 cctggacaag ctgcgcctgg ccaagcagtc ggggaagagc gcacccggcc aggtggtcgg
     7801 aggcgtactg ggaaccgtgc gcgcgggcgt caccatcgtg ggattcctca gttccctcct
     7861 ggtcatcgcc ccgttgatgg ccctgttcgt cctggtcttc gccgtgcccg tgctggtcgc
     7921 cgagatcgtg ctgtcccgtc gcagggcgga catgatctgg cgcatcagcc cgcgggagcg
     7981 ccgcgaattc ttcttcgacc agttgctctc caacgtcgag gccgccaagg aagtgcggct
     8041 gttcggcatc ggcggcttcc tgctgggccg gatgcagacg gagcggctcg cctcgaacgc
     8101 cgcgcggcgc gcggtggacc gccgtgagct ctcgacccag tccctgctgg cgctgttcgc
     8161 cgcgctggtg tccgggaccg gcctggtctg ggccatccac agcgcgctgt ccggtgggct
     8221 cacgctggga gacgtcgcga tcttcatcgc cgccgtcgcg ggggtgcaga gctccgtcgg
     8281 ccagctgtcg gccggcgcgg cccaggccca ccaggcgctg gtgctgttcg gtcactacca
     8341 ggacgtcgtc gccacggaac ccgacctggc gcgcgccgcc gatccgctgc ccgcccccgc
     8401 cctggcacac ggactcgaac tccgcgacgt ctggttccgc tacggtccgg accagccgtg
     8461 ggtactccgg ggggtcgacc tcttcatccc caagggacgg agcacggccc tcgtcggcct
     8521 caacggagcg ggcaagtcca cgctggtcaa gctcctgtgc cggttctacg acccgacgcg
     8581 cggcgcgatc ctctgggacg gcgtcgacat ccgcgagttc gacccggacg acctgcgccg
     8641 gcggacgagc gcggtcttcc aggacttcat gcactacgac ctcaccgcac gggagaacat
     8701 cgcgctcggc gacctggacg cgctggcctc gtcctcgcgc gtcgccgagg cggcccgcaa
     8761 cgcgggcatc gaccggacgc tggagggcct cccccgcgga tacgacaccc tggtcacccg
     8821 gaccttcttc ccgggcgagg agcaggacga cacgaccacc ggcgtcctgc tgtccggggg
     8881 ccagatgcag cggctggccc tggcccgtgc cctggtgcgc gagcagcgcg acttcctgat
     8941 cctggacgag cccacgtccg gtctcgacgc cgaggccgag cacgaactgc acacgcggct
     9001 gagcgagttt caccacgggc ggacgagtct gctcatctcc caccggctgg gttccgtacg
     9061 ggaggcggac gtcatcgtcg tcctctccga gggacggatc acggaacggg gtgaccacgc
     9121 caccctgatg gcccttgacg gctcgtacgc ccggctcttc ggtctccagg ccgccgggta
     9181 cgcgggcggg tccccgtccc tgccggaaca cggaccggcc gccgtggaag gagcggtgcc
     9241 gtgatgtggg cggtggcggg cgggtgcgcg ggactcgtcg tcgcggggac ggcgctgctg
     9301 cgcaggcgcc tcgtctcggt caccgtcacg ggacacagca tgctgccggc gtaccggccc
     9361 ggtgaccggg tcctggtgcg gcgtggtgcc gtcccgcgcc gcggccaagt ggtcgtcgtg
     9421 gagctcccgg acacggagcg ccgcagctgg atttccgaac cggccggact gggcagtccc
     9481 ggaacgccgg tgaccgagcg ccagtggctg ctcaaacggg tctccgccgt ggccggcgat
     9541 ccgtgcggca gccgggacga agcggccggc cgggtgccac cgggccatct gctgctgctc
     9601 ggggacaacg cgtccgtcag tttcgactcg cgtcagatgg ggcccttccc cgtggaacgg
     9661 gttctcggcg cggtgtggcg gcggctgtga cctccggcgc ttgtcaggag cttcttcgga
     9721 gctccgtcgg agggtcgcgg cggaccaagg aaacgcacac cgagaagaga ggaagacaca
     9781 tgcaggacaa cacgcgcggc acgcaggacg acgagagggc gttccccgtg gtgacggagc
     9841 cggaggggca gaccgagctg atcgagatcc gcatgctcga caagatcgag accatcgaca
     9901 gcaaggcggt cgcccggtag tcaccgggtc gtcgccggcc cacggcggac cgttgcgtcg
     9961 gagaagcact ccgggaaggc tggttgtgag acgtccacga gtgaaacggg aacacatccc
    10021 gcaccggttc gacgacggaa cggtccgcct cggcggcgag gtctacggca tcgcggcgga
    10081 gatcaccgac cgccacgggt gggcatggga cgccctgacc ctgatggacg ggacggctcc
    10141 acgccaggac atagagacgg cgctggccga gcggcacccc cgcctcggtg ccgacggcgc
    10201 ccggcggctg gtgcgtgagc tgatcggcac cggctacgtg gaggacgcgg ccgccggccg
    10261 tcccgacggg ttcacggacg gcgagatcga gcgctacagc cgcaaccacg actatttccg
    10321 gcgcgtcgat ctgcgtccgg ggagcgaccc ctgggaggcc caacggcgca tcggacgcgc
    10381 ccgtgtgacg gtgctgggcg tcggaggcac gggcagccac gccgcctggg cgctgaccgc
    10441 agtcggcgtc ggaacccttc atctcgtgga tcccgaccgg gtcgaggtgt ccaacctgac
    10501 ccggcagacg ctctacaccg aggccgacgt cggccgggcc aaggccgagg tggccgcgga
    10561 acggatcggc gcggtcaact cctcggggag gttcacctgt gacgtgcggc gggtggacac
    10621 cgaggacgcg ctgcgcgaac tcgtcgccgg ctgcgacgtc ttcgtgctgt gcgccgacga
    10681 gccgcgcaac gacgtcatca acaagatgac caaccgggtc tgtgccgggc tgggagtccc
    10741 ctgggtgacc gccggctaca acggtcccct ggtgacggtc ggtgtctacg ggcccgaagg
    10801 tccctgcttc gagtgcgtcg gcgcgggcga ggaggccaaa ctgaagcccg gtcggcaccc
    10861 ggatctgggg ggcacgggag cgatggcgcc ggccgccggg atctcgggtc agctcatcgc
    10921 caacgaggtc gtctcgctgg tcaccggtac cgcccggacg cctcccggct tcgtgcgcgg
    10981 catcaatctg atcgccccgg accatctcgt ccacgtgcgg caccccgccc ggccggagtg
    11041 tccgttgtgc agccggtgac ccgtacgggc ggcctcgacg tctccttcca cgagctggag
    11101 ttccgcccgg accgggacga gtggatcgtc ggacggcagg gcaccgacga gatcgtcgcc
    11161 ctgcccggga tcggcatgga cgcgattcgt ctgctgtccg ccggccggac ggtggaggag
    11221 accaggagca gcctgcgtgc gagcaccggc cgggacgtcg atgtccgggc cttcgtggag
    11281 cggctggcgt ccgccgggct ggtggcgtcc atcggtgagc ggcggtttcc cgtcgcaccg
    11341 gccgcggtct cgtttccccg ggtgcgaccg caccaggtac gcctgctcct gaacccggtg
    11401 ctgcacgccg tcctgctcct ggtcccggtc gcgggtctcg cggtcgcgct gacgcgtccg
    11461 ggcaccttcc cctcctggga cagcttcctc tggacggagt acggcacctt cacggtgctg
    11521 gtgcagtgcg tgatcggctg gtgcctcatc gccctgcacg aggccgcaca cctgctgacc
    11581 gcccgcgcca cgggggtgcg cgggcggatc cggctcggta cccgcctcca gttcctggtg
    11641 gcgcagaccg aggtgtccgg catctggctc aagggccggc gggcgcggct cacggtctac
    11701 ctgtcgggca tcgtcctcga cgcggtgatc tggggcggct gcctgctggc tcgcgcctgg
    11761 ggagcggact tcgtcctgct tcccgtcgtc gtggcgaccc tgttcctcgc gctggcgaac
    11821 cagtgcctgg tgttcatgcg cacggacctg tatttcgtcg tccaggacct gacgggctgc
    11881 cggaacctgt tcaccgacac gacccgctac ctgcgccacg tggcggccct gcccttcggg
    11941 cgccgggccc cgcatccgct gcgctcactg cccgcccgtg agcggcgctt cgtcaagggg
    12001 tacgccgtcg ccgtggccgt gggcagcgtg gtctgcctgg ccatcggctt gcgagtgctc
    12061 accgaggtca cctggccgct gctgcgccgg tccctcgtac acatggtgga cggatccgac
    12121 tggtggctgc ggctcgacgc gctcgccacc gtcctggtcc tgtgcggcat gcagacgctg
    12181 tgggcacgcc tgtggtggaa acgccatggt gaccgggtcg ggcgtgcggg gcgggcggcc
    12241 cgcaggtggc ggcgcgatcg ctgacaggag ccccatagcc tgggggaacg ccgctggtct
    12301 acctttcctt gatgcacaac cgctcgcccc ggttccgtct gctcggcccc ctggagatcc
    12361 gagtcgacga caccgccgtt gtcctcaccg gccgccaacg cgccctctgc gcggtcctgc
    12421 tgctgcacgc cgaccgcgtc gtctccgtgg accggctggc ccagggcctg tgggacgagc
    12481 ggatgcccag cgcgtcggcc gcacggatcc gcgccctggt ctccgaggtc cggcacgcct
    12541 tcggtccgga cggagccgcc ctgctggcca cccggaagcc cgggtacgtc ctgcgcgccg
    12601 ctcccgcgga ggtcgacgcg ttcctcttcg aagcgctgat cagggacggg ctgcgggcgc
    12661 tggcgcacaa ggagtgggcg gaggcgtacc gctaccacga cgacgccctc gcgctgtggc
    12721 gcggcgaccc gctccccgat ctgccggcca tggaagcgga acgccggcgt ctgaccgaac
    12781 tgcgcatcgc cgccgaggag ggcagggcgg aggcggaact ggagctgggc cggccgcgct
    12841 ccgccgtcgc cgacctggtc cggctcacgt ccgagcaccc gctgcgcgaa cgcccgcacg
    12901 cgctgctgat gcgctccctg gcccgggacg ggcggtcccc ggacgccctg gccgtctaca
    12961 ccgggctgcg caaccgcatg gtgagggaac tcggcgtcga cccctcggac gaactcacgg
    13021 agctccaccg gaggctgctc gtcggagacg ccgccccccg cgcggccggg tccgctcccg
    13081 ccgagccctc ccggcaccgc tgggtgcccc gccagctgcc ccgggctccg caccgcttcg
    13141 tcggccggaa cacggagctg cgcctgctcg acgtctgccc gcgggaagac ggcgctccgg
    13201 ccgtgatcgt ggggcccgcc ggtgccggga agaccgcgct ggccctgcac tgggcccacc
    13261 ggattgccga cggctatccc gacgggcagc tcttcctgga catgcggggc ttcgacaacg
    13321 ccggtcccat gtccctggag gaggcgctgc cgctgctgct gcaggggctg ggctgcgcgc
    13381 cgcacgacat cccgctgggg ctggacgcgc agaccgcgct ctaccgcacg ctcctggcgg
    13441 gccgtcgggt cctcgtcgtc ctcgacgacg tggccgacgc ctcgacggta cgccggctcc
    13501 ttccctccac cagcgggtcg ctcaccctgg tgaccagccg gcggaagctg aacgggctcg
    13561 tcctggacgg tgcccaccgg gtgacctgcg acgtgctgtc ccgggaagag gcgctggagc
    13621 tgttcggcgc cgcgatcggt gccgacgccg tggcggccga ccccggggcc gcggcccacc
    13681 tggtggaact ctgcgaccac ctgcccctcg ctctgtgcgt cgccggttcc tggatcggca
    13741 ccggggccgg gagcgtccgg gcctacgtca ccagcctcgc ggaacgcggc cgtcttgccc
    13801 ggctgcacgt ggagggggag gagagcgtcg ccgtacgggc cgcgctcgac ctgtcctacg
    13861 ggacgctgcc cgacgaggcg aagtgggtct tccgctccct ggggctgatt ccgggcaccg
    13921 gccgctcggt ggccgcgacc gcggcgggcg cgggactcga cgagtcccac acggccgacc
    13981 tgctcaggct cgcgcagcgg gtgcacctgc tgcgcgacac cgaggacggc cgtaccgcct
    14041 ggcacgacct cgtgcacgag tacgccgtgg aacgcgtggt caccgaggac gccgaagcgg
    14101 agcgggcccg ggcggtcgac cgcctcctcg accactacct gcagagtgtc tcccgcgtcg
    14161 ccgagacgtg ccgcctctac tgcccgcagc cccgtccgga acccgtcggc ggctccgtcc
    14221 cccggacctt ccgcaccccg gaggaggcct tcgcctggtt cgacgaggag tgggaggaca
    14281 tcgcggcggc gatcgcgtac gcggccgagc acgggcccgc ccgcttcgcc tggcagatcg
    14341 tcgacgcgtt gcaggacctg ttccaccacc gccgcccgct gtccgactgg ctgcggctgg
    14401 ccgcgctcgc cgggaaggcg gccgaacgcg gcggcgaccg caggggccag gcggtcgtcc
    14461 acctgtcgtc cggccacgcc ctgtggcgga gcggcgactt caggggtgcc ctcggcgcct
    14521 acgagagcgc acagctcgcg gcccgcgacg ccgggtggct gtcgggagag gcacggagcg
    14581 cgcagggcac gggggtgacg ctgaaactgc tgggcgaacc gcgcgaggca ctgcccttct
    14641 acgaccgcgc cctcaccctc taccgcaccc tcggcatgac ggaggccgag aagatcatgc
    14701 tgaccaacac ggcctccctg cagctcgcgc tcgggcggct cgccgaggcc gaggaggcgg
    14761 tgaccgcggc gctcgcgctc gacgccggca cgcaggggca cctccactcg atgaccctgg
    14821 tgaaccacgc gctggtgcag cagaagcagg cgaggttccg ggatgccgcc gccactctgc
    14881 gcaagggcct ggaggtctcc cgggcctccg aatcgctcta cgcggaggcg gtgatgctgg
    14941 agaccctcgg ccgggtgcgc gacgacgcgg gccaggacgc ccgtgccctg ctcgcctacg
    15001 aggacgcgct cgggctggcc cggcgcgtcg gcaaccgcaa ctgtcaggtc gactccctgg
    15061 tgggtctggc ctccctcgag ctgcgcacgg gccggactcg ggaggcggcc gcccacctgg
    15121 acgatgcccg gaccatcgcc gaggagaccg ggcaccggac cggcctgatc gagatcctgc
    15181 tggtgcgcgg ggccctgcac tgcgcggagg gacggtaccg ggaagcggcg gcggttctgg
    15241 agacggccgg cgggctcgcg gtgaacggca gtcccctcac gctgccccgc atccggagcc
    15301 cgtccgcggt ggccctccgg aagaccggtg agaccaccgc agcgacagag gcggcgcggg
    15361 aggcggtgga gcaggcgcgg cactcgggtc agcgcctggt gctggctcgt gcgctgaccg
    15421 ccctcgccgc cgcccacgag gcccccggtg acgtccggtc ccccgccggg taccgcgacg
    15481 aggcggagac cctgttcgac gcgatcggcg tcccgtcctc ctgccggacg gccaccggac
    15541 gcaggacggc caccggacac cgtggggccg acgccgcgcc ggaccggagc ccggcggcac
    15601 ggatccccgc ggcacggagc gcgcggcctc ccctgccgga cgacgcggcg gaacgtctcg
    15661 cgcgctacct cgccgatcac ttcgacgacc tcacggacga cgggcccggc acgggtgggc
    15721 ggctatgacg ccatggccgc ccacaccgga cggccgccgt gcacgatctc gtccctgcgc
    15781 aggatccgct cgtgcagcat gcgcagcctg cccccgggct cgacgccgag ttccgcgacg
    15841 aaccgtgagc ggatggagcg gaaacagcgc agcgcctcgt cctggcgtcc gctgcggtac
    15901 agcgccagca tcagcagact ggcgatccgt tcgtccaggg ggtgggcctc ggccagctcg
    15961 tggagcaacg gcacgtagtc gtcgcagcgc ccgaggccga gcgcgagttc cgcgctgttg
    16021 atcctcgcgg cccgcagctc ctgcccgaac gtcacgcgcg cggcctccgc ccatgccgtc
    16081 cggacatcgg acaggggacg gccgtggcac agggccagcg ccctctcgta gcgctccagg
    16141 gcggcctcct cctctccccg gcactgtgcg ttcctggcct gccggacgag ggcgcggaag
    16201 cggaggacgt cgaccgtctc ctcggccgcg accagggtgt atccgcccgg ccggcggacc
    16261 acgtcgcacg cggtgtccgg cgcggcgacc gcgtgcagcg ccttgcgcag ccgggtcgcc
    16321 actgtgtaga gggcgtcgcg ggggtgggcc gggaccctgc tctcccagac ccggccgatc
    16381 gtgtcctcgt cggtgatgaa ggagttcgcg gaccaggcca gcgtggccag aaggcggccg
    16441 acggtcgggc tgaccggaat gtttccaccg tctgtggcgc gaagctcgat acaacccagg
    16501 atctgtacgt tcacgcggtc ccctgaaggt cttcgtcggt ctggtgtcag tggtctggtg
    16561 tcagcggcac ctctcactgt gcggaccgga cgttcgggtt ctgcatggat cacgcacgga
    16621 cgtcgcagga cagcgcggcg atttgtccgg tcggccacgc aatggatcac cggaaagcga
    16681 tgcaaacccg ttactttgcg accctcaggt gtacgcattc cgacgacccg gcgcccatat
    16741 aacgaacatc ttgcccgatt ggtccagttg gcccgatgta aggcacggat cgatcacgac
    16801 gtgctacacg cgtaactacg gaatgaccaa gagaaggcaa agaaagtaaa gacaaggtca
    16861 actcgagcca gattttattg accttgaacg aattgcgttg aaaaagtccg gcgtagcccg
    16921 tagggggacg ccctgcggag tcatcagacc ctcccttggg ccaggagcac catgaccccc
    16981 ccaactccat cagcggccgc cccgctcgag gtgaccgacg aaaccgtcga caagtcaccc
    17041 atgcccgcca cccccaaggg cagcgagagc cgttcgccgg gccgactggc ctggaagcgt
    17101 ttcaagcgcg accgcacggg cgtcatatcg gcgtgcatcg tgatcttctt cttcgcgatc
    17161 gcgctcgcgg cgcccctcat cgccaagctg tacggcaagg acccgtacac cacgtacgcc
    17221 agccagcgac ccgagctgct cgacgccttc tcgtacccgg ccggcccgaa cggcggcatg
    17281 agttcggagt tctggttcgg catcgagccg cagctcggcc gggacgtctt caccttcctg
    17341 ctgtacggca tccggacctc gctgggcctc gcggtggccg ccacgatcgt cacggccgtc
    17401 ctcggcgtcg tcatcggcac cacggcgggc tacctgggcg gcaagacgga ctacctcgtc
    17461 ggccggatca tcgacatcct gctgtcgttc ccctccacgc tgttcttcat cgcgttcatg
    17521 ccggtcatct acggcctgtt cgtcgcgccg gacgagaaca tcccgacctc tctgcgggcc
    17581 atctccctca tcatcgtgct gtccggcttc ggctgggcct ccctcgcccg tctgctgcgc
    17641 ggtcaggtac tcggcctgcg cgagcgggag ttcgtcgagg ccgcgaaggt cacgggcgcg
    17701 tctccttggc gcatcgtctt caaggagctg ctgccgaacc tctggactcc gatcatcatc
    17761 cagaccacgc tgatgctgcc gatgttcgtc accgccgagg cggggctggc attcctcggc
    17821 gtcggcatga tcgacccgac gccggactgg ggcgtcatga tccagcgagg cgcccagttc
    17881 tacaccgagg acctcacctt catgctcttc ccgggcctct ccatggtgat cttcgtcctc
    17941 gccttcaacc tgctcggcga ctcggtgcgc gacgcgctcg acccgaagac caagcgctga
    18001 tccgttcctt ccccggtccg tacacaggaa tctggccggc cacctccgtc ccgtttgacc
    18061 acccttggta ggttctccat ggctttctcc cgcagaaact tcctcatagc gaccggtgtc
    18121 gtcgcggcct cctcctcggt cctgaccgcc tgtggcggca gtgacaacaa gggcggcggc
    18181 ggcaagagcg acgctccgaa ggtctccggt tccaagaccg tcgagatcct ggtcggcacg
    18241 aaggccgact cgaccggtcc ggcgcccgag gtcaagggtg cggtgaaggg cgggatcgtc
    18301 cactcgctcg accagttcga catggaccac atggacccgg cgcagatcta cgtctcgacc
    18361 gagggcgcca tcaccgtccc gatcatgcgc ggtctgaccg gctacaagct ggacgacaag
    18421 ggcggctgca ccctggtcgg cgacgtcgcc accgacgccg gcacgatgaa ggacggcggc
    18481 aagacctggt cgttcaccat caaggacggc gtgaagtggg aggacggctc cgacctctcc
    18541 atggacgacg tccgccacac cttcgagcgc ctcttcgcgg acttcgtcac cgagggcccg
    18601 cgctacgtgc agcagttcct cgtcggcggc gacaagtaca agggcccgta cgacggcaag
    18661 cagctcgact ccgtcgaggt cgacggcaag accatcacct tccgtctcaa cgagccccgc
    18721 gccgacttca acttcacgct ggccatgcgc ggctactccc tcgtgcccaa ggcgaaggac
    18781 accaagcaaa agtacgacag ccgcccgttc tcctgcggtc cctacaagat cagcgagcgc
    18841 agcgtcggca agtccctgac ctacgtgcgc aacgagcact gggacccgaa gacggacgcg
    18901 atccgcaacg cctacccgga ccagtaccag ttccggttcg gctaccagcc gctggccgcc
    18961 accgaccgct tcatcgccga ctccggcgag gaccagcagg ccatggcgat cttcaacgag
    19021 gtcgcgccgg agcgcatcgc caaggtgctc accgacccga acctgaagaa gcgcgtcctc
    19081 accgcggtcg acacggtcac ctactactgg ccgatcaaca ccacccgcat caaggacgtc
    19141 aaggtccgcc aggccatcaa ctgggcctgg ccgcaccagc agctccagac gatccgcggc
    19201 ggcgcctcca ccagcgagct cgccaccacc atcctcagcc cggtgacccc cggccacgag
    19261 gagttcgacc tgtacggcgt cgacaagaag cccggcggcg acccggagaa ggccaaggcg
    19321 ctgctgaagg aggccggcaa ggtcggccag aagctggtca tcgcgtacca gacctcggac
    19381 aacgcgctga agcaggccgt cgccatcaag aacgccctgg aggccgcggg cttcaaggtc
    19441 gtcaacaagc agctcgacaa gtcgaccttc tacacccaga tcggcaagat cgacaacggc
    19501 tacgacctgt tcgcggccgg ctggagcccg gactggccga acggctactc ggtgttctac
    19561 ccgtgctgga gcggtgagaa catcggcaac ggccgcagca actacgccca gctggacgac
    19621 cccagcgtga acaaggcgat caacgccgcg tccaagatcg ctgacgcgga ggaggccaac
    19681 aaggcctggg gcgccatcga ccgccagatc atggagctcg cggccgtcgt gcccgactac
    19741 cactcgatcc gcaactggat gtacggatcg aagatcggca acgtcgtgtt cgactacggc
    19801 aacacctgca tcgccctctg caagctctac gtcaagaagt aggcgcgcag acgcacaggg
    19861 gggcggccac cacccttatg gccgccccct gaggcccacc cccctctcac cccggcgacg
    19921 gcgccccgtc cggaaagtca cgccccatgt tccgcttcct agtccgccga gtcttcggcg
    19981 cgttggtcat tttgctgatc atcagcgcca tcaccttctg gctcttctac gccgtgccgc
    20041 gcgaccctgc catgatgtcc tgcggcaaga actgcacgcc ggaaaacctt gagcagatcc
    20101 ggaagaacct gggcatcgac gagtcgatcg tcatgcagta ctggcactgg ctctccggca
    20161 tcttcgcggg ccgcgactac gccggttacg gcaactgcga ggcgccgtgc ctcggctact
    20221 cgttcgccaa caaccagccc gtctacggca cgatcatgga ccggctgccg ctgaccctgt
    20281 cgctcgcctt cggtgcggcc atcttcttcc tgatcatcgg catcggcgcc ggcatgctcg
    20341 cggcctcgaa gcagggcaag ttcctggaca agttcgccag ctccgtgtcg ctgctcggct
    20401 cctcgctcca gatctacttc gtcggctaca tcgccatgtt cttcctggtc ggtgagctcg
    20461 gcatcctcag ccagccgtcg tacacgccgc tgaccgacga cccggccgcc tgggtgtccg
    20521 gcctgctgct gccctggctg gtgctgtcga tcatcttcac cgccaactac acccgtatga
    20581 cgcgttccca gatggtggag cagctgagcg aggactacgt gcgcaccgcg cgggccaagg
    20641 gcctgtcgaa gcgcaacgtc ttcttccgct tcgcctggcg cggtgcgatg ggcccgatcg
    20701 tcaccatctt cggtgtcgac ctcggtgtcc tgatcggcgg cgccatcatc accgagacga
    20761 ccttcagcct ccagggcatc ggccggctcg cgatcgagtc cgtgttcaag agcgacctgc
    20821 ccatgctgct cggcgtcacc gtgctggcgg ccggcgcgat cgtgctcttc aacatcgtcg
    20881 tcgacgcggt ctacgccctc atcgacccgc ggatccggct cgcctgacct gcgcccgcca
    20941 cagtcgcctc tcccaccgcc ccacccggct accccccgca tcacctcctg gagcgtcccc
    21001 gtgacgagca ccgaacagca gcccttcctc tccgtcaggg acttgaaggt ccacttctc
//
