LOCUS       NZ_WHZR01000001        27765 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. OM5714 A912_AS4_SC1_R2, whole genome shotgun
            sequence.
ACCESSION   NZ_WHZR01000001
VERSION     NZ_WHZR01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. OM5714
  ORGANISM  Streptomyces sp. OM5714
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M.
  TITLE     Whole Genome Sequence of the phthoxazolin producer Streptomyces sp.
            OM5714
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2019) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2017
            Assembly Method                   :: Newbler v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010993835.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:48:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,730
            Genes (coding)                    :: 7,557
            CDSs (with protein)               :: 7,557
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 7, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 7, 5 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 58 of 173
            Pseudo Genes (incomplete)         :: 139 of 173
            Pseudo Genes (internal stop)      :: 18 of 173
            Pseudo Genes (multiple problems)  :: 36 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:03:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1520282
            Orig. end                         :: 1548047
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHZR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27765
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="10"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..27765
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27765
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:17765]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17765
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(454..924)
                     /locus_tag="STPH1_RS06470"
                     /old_locus_tag="STPH1_1297"
     CDS             complement(454..924)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445403.1"
                     /locus_tag="STPH1_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1297"
                     /product="hypothetical protein"
                     /protein_id="WP_164382380.1"
                     /transl_table=11
                     /translation="MNHTPTVTTPRTPAAAVTGMVDHVLALAATWTRWDGRPAHSDGRV
                     HTPHKAIRRVADHMIDHLAELEARLAGEETQPDHWHASAVTTDADRARFTGEDLDEARS
                     RLTRLARIWANRLDALTDEQLDHSPGEGWSFRELAVHLTESVYYADSVGDLS"
     misc_feature    959..973
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(1027..1037)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            1032..1568
                     /locus_tag="STPH1_RS06475"
                     /old_locus_tag="STPH1_1298"
     CDS             1032..1568
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972781.1"
                     /locus_tag="STPH1_RS06475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1298"
                     /product="hypothetical protein"
                     /protein_id="WP_240468961.1"
                     /transl_table=11
                     /translation="MASEERSEDRPRLRWQDSLWGIGGTALAVGIGVQLVLHGVTAWPS
                     ALVGAVPAAAWIVWWVRRRRVRDAGRVGTEPEDVPAMERRILKGGPAPRDPERRRAMAA
                     FVDSRQERLRRHRWWAFPVLALIFFGTSALWYVSGSVGAGTMMLGLGVVFLGWLAWYNA
                     RFDRRLSQMRGRLQG"
     gene            complement(1585..2247)
                     /locus_tag="STPH1_RS06480"
                     /old_locus_tag="STPH1_1299"
     CDS             complement(1585..2247)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972782.1"
                     /locus_tag="STPH1_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1299"
                     /product="response regulator transcription factor"
                     /protein_id="WP_153177295.1"
                     /transl_table=11
                     /translation="MSAPVRVVICDDQALIRTGLATIVDAQPDLEVVGECGDGQAGVDL
                     ARELRPDVVVMDIRMPVLDGLEATRLLAGAGVQHPVKVLVVTTFNLDEYVYEALRAGAS
                     GFLLKDAPPDRLLHGIRTVAMGAALLDPDVTRRLVGRYAARIRPAEGGTTRDIPLTPRE
                     MEVLRLIADGLSNSEIAAALVISPETVKTFVSRILTKLDLRDRVQAVVFAYRHGLVT"
     gene            complement(2244..3401)
                     /locus_tag="STPH1_RS06485"
                     /old_locus_tag="STPH1_1300"
     CDS             complement(2244..3401)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972783.1"
                     /locus_tag="STPH1_RS06485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1300"
                     /product="histidine kinase"
                     /protein_id="WP_153177296.1"
                     /transl_table=11
                     /translation="MIDRRGIVERWHRLDVTVRDLPLGMLLLLASLVPSLQGQGTEIGG
                     LPTRPADALAGVAAVLQSVPLAVRRRWTLVCLALVSVGFALDQLRGYHLFAGAALPIVL
                     INAGSHQEKYRRATQIAGTLAYVAMAVGLNARGGDETLVEYVTFYLILALAWGVGAWMR
                     SARAAEDERRRRVAEDARTAERTRIARELHDVVTHHVTAMVVQSEAARYLTAAPDRLDE
                     TLAAVSDTGRRAITDLRHLLDLLNPDHGTAEPRTPPVGRVLTLVEQTRRAGQPVEFTEE
                     GTPAAATGSSDLVAYRVVQEALTNALKYDHGAQTSVLVRHGEREITVEVGTDGSGTGAA
                     SPGGSGRGLAGLRERVDVLGGEFSTDRPGGGGFVVRARIPGGSTA"
     gene            complement(3398..4240)
                     /locus_tag="STPH1_RS06490"
                     /old_locus_tag="STPH1_1301"
     CDS             complement(3398..4240)
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972784.1"
                     /locus_tag="STPH1_RS06490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1301"
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="WP_164382384.1"
                     /sec_met_domain="Abi (E-value: 1.4e-11, bitscore: 43.3,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFVWQFLAVLAAYALGGIAVQAVKDNDWLTLVVGLTSAALVVFV
                     YAWVVRRTERRQALDVAREGAAAKAGWGALIGFGLFGAVITNLFASGYYEVDGLGSVQG
                     AIGLVGFMAAAAATEEVVFRGVLFRIIEEHIGTYLSLGLTGIVFGLMHLLNEDATLWGA
                     LAIAVEAGFMLAAAYAATRNLWLVIGVHFGWNFAAGGVFSTVVSGNGDSEGLLDATVSG
                     PKLLTGGDFGPEGSVYSVGFGVLLTLVFLWLAHRRGNIVAFGSRRRAAGVDSAATLPR"
     gene            4401..5324
                     /gene="mmuM"
                     /locus_tag="STPH1_RS06495"
                     /old_locus_tag="STPH1_1302"
     CDS             4401..5324
                     /EC_number="2.1.1.10"
                     /GO_function="GO:0047150 - betaine-homocysteine
                     S-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mmuM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445390.1"
                     /locus_tag="STPH1_RS06495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1302"
                     /product="homocysteine S-methyltransferase"
                     /protein_id="WP_164382386.1"
                     /transl_table=11
                     /translation="MTSDFADALASGPLVLDGGLSNQLEAAGHDLGDALWSARLLADDP
                     EAITRAHLAYFEAGADVVITSSYQATFEGFARRGIGGQRAAELLALSVESAREAARRAR
                     VGPAGRAGRRRWVAASAGPYGAMLADGSEYRGRYGLDVGELERFHRPRLEVLAAARPDV
                     LALETVPDTDEAVALLRAVRGLGVPAWLSYTVDGDRTRAGRPLEEAFALAADAEEVVAV
                     GVNCCAPGDVSGAVRTAARVTGKPVVAYPNSGEVWDARARAWRGRSLFAPGLVREWRAA
                     GARLVGGCCRVGPDAIRSIASAPSSC"
     gene            complement(5326..6195)
                     /locus_tag="STPH1_RS06500"
                     /old_locus_tag="STPH1_1303"
     CDS             complement(5326..6195)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445398.1"
                     /locus_tag="STPH1_RS06500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1303"
                     /product="DUF6282 family protein"
                     /protein_id="WP_164382388.1"
                     /transl_table=11
                     /translation="MTAADGAARTARFVDVHYHCGPDAYVRRHTATAAAARYAEHGGWV
                     VLKNHLGSTAAQAWEARQQGLPVSGSIVLNDLAGGFDPRAVEQAVVQHGEDSGLRLIVH
                     LPTVTGRAHRSRLTRTPSHPLLAGGQRPLTVTDDSGTLRPDVRELLRAARDLPVVVSTG
                     HADGHEVRLLIEEAVRLDLPRLMLNQPANPMTGLTCKDLADLVGAEQVFTEQTALTHLL
                     GYQPWSDLADVLTLLPRVVYSSDLGQPSQPDITPWLTQSAEWFERAGLTPRRVQEVTRD
                     TPLAMLSL"
     gene            complement(6182..6895)
                     /locus_tag="STPH1_RS06505"
                     /old_locus_tag="STPH1_1304"
     CDS             complement(6182..6895)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445397.1"
                     /locus_tag="STPH1_RS06505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1304"
                     /product="RraA family protein"
                     /protein_id="WP_164143493.1"
                     /transl_table=11
                     /translation="MTTATAPSGDTGELRRRLARLDTAALSDAMDSLRTPPCVLPGIRP
                     RTPGTLACGPAFTVRYRPLDPDARGFRNAADYIDEVPAGSVVVVDNGGSLTCTNWGSLL
                     SSVALHRGVSGTVVHGSVRDVAESRAAGYPLFSTGVTMVSGKNRVVLDRTGVSVDVAGT
                     TVDPGDWIVADDNGALRVPAALAGEVLRRAEAVDRTEARIRAAVLDGSRLDGARARFGY
                     ARPWEDEDGGRHDGR"
     gene            complement(6892..9105)
                     /locus_tag="STPH1_RS06510"
                     /old_locus_tag="STPH1_1305"
     CDS             complement(6892..9105)
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012407.4"
                     /locus_tag="STPH1_RS06510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1305"
                     /product="isocitrate/isopropylmalate family dehydrogenase"
                     /protein_id="WP_164382390.1"
                     /transl_table=11
                     /translation="MNRKTVAVLPGDGIGPEVLDAALPVIDALDLPLDLEFGDIGWECW
                     RAEGTPVPDRTWDLIDRSDAVLLGATTTKPRGEALAELAPELRASAPRYVSPIIQLRRR
                     LDLFANLRPVENYLGGTTPYRYCVVRENTEGLYAGLDFSPVPDALWPLVADHPNVRRST
                     RTGAAASVRLQTAHGLDRILRFAFETARTHGYGRVTLADKPNVLRDSSAYVLNRLEDIA
                     GDYPEIPYEVLNVDAVALWMTRRPERFGVIVAENMFGDILSDLGGGVMGGLGLAPSANI
                     GENGNYFEPVHGSAPALAGRQRANPTAAFLTVGLMLDHLGFTEAAGAVKDAVRHVTRRR
                     DRVTYDLGGTATTAEAAEAVVDACRALPQAPTAAVVTVGDELLRGDLEDSNAGHASRLL
                     AERGIPVRARHTVGDDEAGIADAVRSCLGRDDVVVVMGGLGPTSDDVTRGAVARALGRP
                     LEHREEAWQAVVARLTRFGVAVHDDNRRQALFAEGAELLPNPNGTAWGCRAETQGSTVL
                     MLPGPPRECLPMLEESLRDGLPHIPRPPETTTLFRRTLGVIEADAAALVDALVKEYGGP
                     ARTAYRWHYPYVDIRVTCPPEDAADLARRLDATLARHVVTDRDRTAVQELAAVLDEHDV
                     VLDVDDRLTGGLFAAELARARATGDGSRSLRVTLSGRWDGGDRTTYTGTVALNCAVREG
                     TDERTDTLTVPNRGAEVTAYAAQYAAWTLTRHLTGHPHPKDPA"
     gene            complement(9102..10004)
                     /locus_tag="STPH1_RS06515"
                     /old_locus_tag="STPH1_1306"
     CDS             complement(9102..10004)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="STPH1_RS06515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="STPH1_1306"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_164382392.1"
                     /transl_table=11
                     /translation="MTRPGPPSEPTHDTAPVPAHAVLGPVGAPRHAIVLAPVLARWDHG
                     AFFRRIAGPFLDSGHRVTIHDTLSLLRDGDDLGSLVHRWARYLAPRENPGPASGAHGPS
                     GHAPPDVLVGNALGGAVVQGMLGEEWTHRAKVLLLSGPTVADHRLNTTLERIAATADAE
                     GLPAATRLLEDVVRGPDEPAAAAHRRPAAPNAPARTAAPAAPARPTAADEPAAARRLAA
                     GLRLLHDADARHPVRDFPGPLLHVYGERSRLVGREHLATGPLPHHRLVAVPRAGMRPHA
                     DRPDLVRHTLTRFLGAELT"
     gene            complement(10001..10933)
                     /locus_tag="STPH1_RS06520"
                     /old_locus_tag="STPH1_1307"
     CDS             complement(10001..10933)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012885.4"
                     /locus_tag="STPH1_RS06520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1307"
                     /product="3-hydroxy-3-methylglutaryl-CoA lyase"
                     /protein_id="WP_164382394.1"
                     /sec_met_domain="HMGL-like (E-value: 2.6e-34, bitscore:
                     117.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVINLDVTLRDGGYRNNFDFPLDYARHHVRESVAAGMEWIEIGYR
                     NGSFKPRPGIGRTGLGADDYIRALAEVVPPEHLCMIVHPKNITEEDLPRMYEAGARMVR
                     FCLPSGAPEAGLALLAQAVDLGFTTTVNITRVSQLDGRRLAELAAMSGDSGADVVYLAD
                     SNGSMLPREVSRLVTLVRSVTDAAIGLHAHNNLGLALANAIAAVEAGATWIDSSVLGMG
                     KGPGNLVTEQWLAYLGRRGRTEGHDLGRILALAHRMEGEFAEAAPSLPLPDLVLGHFDL
                     SVEERAKLPQGRISDAFSAARELTATGAR"
     misc_feature    complement(10902..10915)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.37"
                     /tool="antismash"
     misc_feature    complement(10919..10934)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.76"
                     /tool="antismash"
     misc_feature    10924..10938
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.28"
                     /tool="antismash"
     misc_feature    complement(11002..11017)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.54"
                     /tool="antismash"
     misc_feature    complement(11177..11186)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.02"
                     /tool="antismash"
     gene            complement(11184..12095)
                     /locus_tag="STPH1_RS06525"
                     /old_locus_tag="STPH1_1308"
     CDS             complement(11184..12095)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018531691.1"
                     /locus_tag="STPH1_RS06525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1308"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_153177304.1"
                     /transl_table=11
                     /translation="MELRQIQYFVAVAEDLHFGRAAERLHIGQPAVSQQVRRLERELSA
                     ELFDRSGRTVTLTPAGRALLPEGREVLRAMDSFAATARRLAAQGDATFRVGISSALGRR
                     LDDFLDALPDRGAGTRFEFQTLDAHTRLEEVRAGRLDAAFVRGLESAPGLLLLSLWQDP
                     LVVALPAAHALAGRDRLRLADLARLPLRIAPRAENPVLFDTVVLACRKAGFEPALGPPS
                     TGLQETLAEIGAGAGGWIPMYPAAAGTVSSRRVAVLPLDGEPVAIRMSLALRADADPER
                     LKLLTETSARVRGKSAGKETSA"
     gene            complement(12298..13629)
                     /locus_tag="STPH1_RS06530"
                     /old_locus_tag="STPH1_1309"
     CDS             complement(12298..13629)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387913.1"
                     /locus_tag="STPH1_RS06530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1309"
                     /product="multidrug effflux MFS transporter"
                     /protein_id="WP_164382396.1"
                     /transl_table=11
                     /translation="MRTASTPVPRPARTSYGLLLAVLCSLNAGGLFASDINLPGVPDTA
                     QAFGAPVASVQWTFSAFMIGIAVSQAVYGPISDAYGRKRVIVFGLGLFVAASLVCAAAP
                     TIEVFGAGRLLQALGAGSGMVLGRAVISDLYEEKDAARTFATVMPIVGVSPSVAPLIGG
                     YLTSYVSWRAPFAVTALIGLATLVVMVARIPESLPPQRRSKHLAATLKGYPGLLTRPLF
                     WAYTVNLAVAYGGYFGYLAASPLVFQKMGLATETTSYCYITVSVAYVAGNLTSRALVRR
                     RRIDELLWAGHGFFLAGALLMLGLGLSGAGGRWGLLVLVFMPVMTFGNGFLLPLSMSAG
                     VTAFRTTAGSASGLMGALQLLGASLGIYLTSRLPAGDLLALGWFVLAASAVGVVLFALF
                     LWLAAQGRATGSPRSDDTATAPPVATAATGAGERPKEVQEAVAE"
     gene            complement(13711..13908)
                     /locus_tag="STPH1_RS06535"
                     /old_locus_tag="STPH1_1310"
     CDS             complement(13711..13908)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387912.1"
                     /locus_tag="STPH1_RS06535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1310"
                     /product="4-oxalocrotonate tautomerase family protein"
                     /protein_id="WP_164382398.1"
                     /transl_table=11
                     /translation="MPLIHVQQTPGKTAEQKSELVRALTDAYVSATGSKPESVWVTVQE
                     IATDSWSIGGDTLAARAARS"
     misc_feature    complement(14041..14055)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.14"
                     /tool="antismash"
     misc_feature    complement(14042..14055)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            complement(14105..14995)
                     /locus_tag="STPH1_RS06540"
                     /old_locus_tag="STPH1_1311"
     CDS             complement(14105..14995)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645137.1"
                     /locus_tag="STPH1_RS06540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1311"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_164382400.1"
                     /transl_table=11
                     /translation="MTLPNHLYAQRMNVELRHLRCFLAVAEEGGFTAAAHRLHLAQPTL
                     TRNIRTLEESLGVRLFERTTRRTELTGKGEALREAVVPLLRQLDSALTDLRNGDTLRVG
                     FSWGLPEGLSRLAARFTEATGTGVEFIRCDTPRAGLDTGRADVALLRSTPLPKGLRGVL
                     LYEEPRSAAVPAGWKLAERSELDWAELAGLPLIVNTVSGTTFPDMWPAGSRPVVGSECR
                     NFDEWLEQVAVGLGVGTAPVSAARRYTHPSVRIMPLTGAPTVPAYLTYPSHGAHPQAAR
                     FTDHAWRAAEELQPA"
     misc_feature    complement(14987..14989)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15316..15331
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            15334..16164
                     /locus_tag="STPH1_RS06545"
                     /old_locus_tag="STPH1_1312"
     CDS             15334..16164
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (23-130). E-value:
                     2.9e-15. Score: 48.5. Matches aSDomain:
                     nrpspksdomains_STPH1_RS06545_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="STPH1_RS06545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1312"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_164382402.1"
                     /sec_met_domain="PF00561 (E-value: 7.4e-12, bitscore: 44.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.6e-13, bitscore:
                     49.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVITMRNGPLEHVVIDGNSDLSPLVFLHGGLGCLAAWGRFPAQL
                     AAATGRRALVYSRHGHGGSGPDPLPRTDRYMHEHAHEVLPELLDALGMRRPVLVGHSDG
                     ASMALLHASAHPVRAVVGMGPHLYFEEENRRGIENARASYAAGPLARKLAMVHDDPRGV
                     FDRWSGVWLSPAFRDWSIEDELDVTAPVLAIQGDADEYGTLAQVDAVERAVDGPFVRLV
                     PEGCDHYPHLVRPGLVVDAVRGFLAEPATFAAAPSARTAHTAHTDRIPSAGAGR"
     aSDomain        15403..15723
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STPH1_RS06545_Abhydrolase_1.1"
                     /evalue="2.90E-15"
                     /label="STPH1_RS06545_Abhydrolase_1.1"
                     /locus_tag="STPH1_RS06545"
                     /protein_end="130"
                     /protein_start="23"
                     /score="48.5"
                     /tool="antismash"
                     /translation="PLVFLHGGLGCLAAWGRFPAQLAAATGRRALVYSRHGHGGSGPDP
                     LPRTDRYMHEHAHEVLPELLDALGMRRPVLVGHSDGASMALLHASAHPVRAVVGMGPHL
                     YFE"
     gene            16161..17765
                     /locus_tag="STPH1_RS06550"
                     /old_locus_tag="STPH1_1313"
     CDS             16161..17765
                     /NRPS_PKS="Domain: AMP-binding (13-427). E-value: 2.5e-90.
                     Score: 294.9. Matches aSDomain:
                     nrpspksdomains_STPH1_RS06550_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="STPH1_RS06550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1313"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_164382405.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-94, bitscore:
                     315.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTAPRLDALLARAARDHPGRTALEGAGESWTYARLERAVDAL
                     AARLAATGVAPGDRIGVHAPKTPATVVALYAVLRAGAVAAPLDTADPPERTARMIRNAG
                     LSALLTVDRTLTGARRAVVRARDGRTRDDAPATAEALDHGLHLLRCLGPDERPAPLPPP
                     ADRGGYILFTSGSTGWPKGVLLSHENVAHYALWAAREFGLTPDDRIGSQAALTFDLTTF
                     DLFSAAAAGACTVLMPDPLRVFPRDVVAWLTEQRVTAFMAVPSLYHAMLQQGGVADAPP
                     ATLRIAAFGGEPFAPELLERYLRLFDGVPFYNLYGPTETNACTYYRVPADWTAGRELPI
                     GRGIDGVHVDVLDDEGRPTDGEGEIHIAGPVVFQGYLRGGAPEDPTVTAVFRDGVARRA
                     YASGDLGRMRPDGQVLLRGRRDHQVKRRGHRIDLMDVENAVLELEQVVTAAVVAKEGSH
                     GPDGPDGSRTGEIWAYAQTDATEHEVLAALRGVLPKRMLPDRVVPLTTLPTTTSGKVDR
                     RALSGTTGPAHPEDVTV"
     aSDomain        16200..17441
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STPH1_RS06550_AMP-binding.1"
                     /evalue="2.50E-90"
                     /label="STPH1_RS06550_AMP-binding.1"
                     /locus_tag="STPH1_RS06550"
                     /protein_end="427"
                     /protein_start="13"
                     /score="294.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ARAARDHPGRTALEGAGESWTYARLERAVDALAARLAATGVAPGD
                     RIGVHAPKTPATVVALYAVLRAGAVAAPLDTADPPERTARMIRNAGLSALLTVDRTLTG
                     ARRAVVRARDGRTRDDAPATAEALDHGLHLLRCLGPDERPAPLPPPADRGGYILFTSGS
                     TGWPKGVLLSHENVAHYALWAAREFGLTPDDRIGSQAALTFDLTTFDLFSAAAAGACTV
                     LMPDPLRVFPRDVVAWLTEQRVTAFMAVPSLYHAMLQQGGVADAPPATLRIAAFGGEPF
                     APELLERYLRLFDGVPFYNLYGPTETNACTYYRVPADWTAGRELPIGRGIDGVHVDVLD
                     DEGRPTDGEGEIHIAGPVVFQGYLRGGAPEDPTVTAVFRDGVARRAYASGDLGRMRPDG
                     QVLLRGRRDHQVKRR"
     CDS_motif       16386..16424
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS06550_0001"
                     /evalue="9.30E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="STPH1_RS06550"
                     /protein_end="88"
                     /protein_start="75"
                     /score="9.7"
                     /tool="antismash"
                     /translation="AVLRAGAVAAPLD"
     CDS_motif       16665..16721
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS06550_0002"
                     /evalue="2.40E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="STPH1_RS06550"
                     /protein_end="187"
                     /protein_start="168"
                     /score="26.2"
                     /tool="antismash"
                     /translation="YILFTSGSTGWPKGVLLSH"
     CDS_motif       17247..17294
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS06550_0003"
                     /evalue="2.60E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="STPH1_RS06550"
                     /protein_end="378"
                     /protein_start="362"
                     /score="13.5"
                     /tool="antismash"
                     /translation="GEIHIAGPVVFQGYLR"
     CDS_motif       17412..17471
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS06550_0004"
                     /evalue="5.50E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="STPH1_RS06550"
                     /protein_end="437"
                     /protein_start="417"
                     /score="25.2"
                     /tool="antismash"
                     /translation="GRRDHQVKRRGHRIDLMDVE"
     gene            17762..18025
                     /locus_tag="STPH1_RS06555"
                     /old_locus_tag="STPH1_1314"
     CDS             17762..18025
                     /NRPS_PKS="Domain: PP-binding (19-74). E-value: 3.3e-11.
                     Score: 35.3. Matches aSDomain:
                     nrpspksdomains_STPH1_RS06555_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="STPH1_RS06555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1314"
                     /product="acyl carrier protein"
                     /protein_id="WP_087789116.1"
                     /sec_met_domain="PP-binding (E-value: 1.7e-09, bitscore:
                     36.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSVEELCALIGSRITWGPGEDASSLTADTPLLEMGLVDSLAIME
                     IVAALDKEAGVTLPDTEIVAANFRSPKALWAAIESLAVEGRP"
     aSDomain        17819..17983
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STPH1_RS06555_PP-binding.1"
                     /evalue="3.30E-11"
                     /label="STPH1_RS06555_PP-binding.1"
                     /locus_tag="STPH1_RS06555"
                     /protein_end="74"
                     /protein_start="19"
                     /score="35.3"
                     /tool="antismash"
                     /translation="GEDASSLTADTPLLEMGLVDSLAIMEIVAALDKEAGVTLPDTEIV
                     AANFRSPKAL"
     gene            18022..19182
                     /locus_tag="STPH1_RS06560"
                     /old_locus_tag="STPH1_1315"
     CDS             18022..19182
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004933757.1"
                     /locus_tag="STPH1_RS06560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1315"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_164382407.1"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 9.1e-20, bitscore:
                     69.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.1e-19, bitscore:
                     67.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATTIAAPRSCAPETEAVVDAHRDLAAPVVERIRDADFTAGWRA
                     MADLGVLRLAPPDAAAPGPVTRALAVIEGIGLAGVDPGLCYALASQVFGMQFPLRATLP
                     AAAWDAVADVQDGRSLLCHALTERGGGSDPFSMETRAVRDADGFVLDGAKTFITAAPVA
                     DRAIVFARTAQGRSPFALSAFLLPLDLPGVRRGETFAKTALPTVPMGELVFEGARLPAG
                     ALLGEEGSGLAVMASTTAWERSVILGYALGPMHRLLTRTVEWAAGRDHFGRRMGASHQV
                     AARVSDMALALHRSRVQLYAMAARLDAGTPARQLAAEAALTKISVSEDYVRMTEHATAL
                     SGVRAFLPGFDLAADLSSPMAALTYAGPNDLLRVAVARQLGLPVEN"
     gene            19386..20573
                     /locus_tag="STPH1_RS06565"
                     /old_locus_tag="STPH1_1316"
     CDS             19386..20573
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="STPH1_RS06565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1316"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_164382409.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.3e-07, bitscore:
                     30.9, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 9.5e-16, bitscore:
                     56.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.4e-12, bitscore:
                     45.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPTHFDDLLKLAADTGSAIAPLAAGTDAADDDGHEAYRVLRES
                     GLLALLVPREAGGAGLGFGDYWRVLAELGAHHGAAALGFNMHHVVIGALAEAAGTRLSP
                     AADAFQTWMLGEVVDGRKMFASATSEAGRGAKLRGMRTRYRRSDDGTHYVLNGRKDFVS
                     LAGAADYYVVAAADGDAEETAEVSHFVVAADDPGVGFGPVRHMSAMYGTSTAPMTLDEV
                     VVPRSRLYLGVEGMSLFKVVREPHWMFAGYTGAYLGMAEALYRHTVDRVTAAPGRAGSP
                     VVQQELGRMSARLRAARALVHEAGDLVTAERGSLEANAMVHAAKYVVGETGPRLAQDAL
                     RLCGSAAVSCGQTLERLIREVQFAHVMPAKPHECLEYLGKAATGVNLYDARTFSW"
     gene            20570..21121
                     /locus_tag="STPH1_RS06570"
                     /old_locus_tag="STPH1_1317"
     CDS             20570..21121
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013756.4"
                     /locus_tag="STPH1_RS06570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1317"
                     /product="flavin reductase family protein"
                     /protein_id="WP_164382411.1"
                     /transl_table=11
                     /translation="MTPASTTASMPPAPRAGDEHAVPHDAFRALMGSHPGGVAVVTTAD
                     ARGTPYGFTCTALCSVSLDPPQLLVCAAAGGSTLPVLAARGAFTVNLLHGSGRRAAQAF
                     AGPAAERFTTVPWRPGLLTGLPVLPQDAHATAECRVARTVPAGDHTIVIGEVLHTETHV
                     PAAEAAPLLYGMRRYATWPV"
     gene            21181..21603
                     /gene="panD"
                     /locus_tag="STPH1_RS06575"
                     /old_locus_tag="STPH1_1318"
     CDS             21181..21603
                     /EC_number="4.1.1.11"
                     /GO_function="GO:0004068 - aspartate 1-decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="panD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004954456.1"
                     /locus_tag="STPH1_RS06575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1318"
                     /product="aspartate 1-decarboxylase"
                     /protein_id="WP_087789120.1"
                     /transl_table=11
                     /translation="MYRTLMKSKIHRATVTQADLHYVGSVTVDSDLMHAAGLLPGEKVD
                     IVDIDNGARLSTYVIEGPAGTGVLGINGAAARLISPGDLVILIAYAAMTDEEAASFVPD
                     VVFVDEHNAVAGLGSDPAEVPAGSGLKRGDLVAEVS"
     gene            21600..22334
                     /locus_tag="STPH1_RS06580"
                     /old_locus_tag="STPH1_1319"
     CDS             21600..22334
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (4-156). E-value: 1.1e-18. Score:
                     59.7. Matches aSDomain:
                     nrpspksdomains_STPH1_RS06580_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019433623.1"
                     /locus_tag="STPH1_RS06580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1319"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_164382413.1"
                     /sec_met_domain="adh_short (E-value: 1.9e-35, bitscore:
                     121.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLAVVSGGTRGIGRALSLRLAALGHRVVALYRGDDDAARRTEKA
                     GDGRIEALRCDLARPQEVRAVCASLTARHGAPSVLVNNAGVNRDRPFLSMTDRDWDTVL
                     ATNLSGPFHLTRALAPAMVQAGGGSVVNVASTTAIRPRADGANYCASKAGLLQLTRCLA
                     LELAPHVRVNALLPGFTDTEEVTERYRLDDPERLGAVLDTIPRGRLGTAEDMADALEFL
                     VSAHSGYVSGQQLVVDGGHFMG"
     CDS_motif       21612..21692
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS06580_0001"
                     /evalue="2.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="STPH1_RS06580"
                     /protein_end="31"
                     /protein_start="4"
                     /score="13.8"
                     /tool="antismash"
                     /translation="VVSGGTRGIGRALSLRLAALGHRVVAL"
     aSDomain        21612..22067
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STPH1_RS06580_PKS_KR.1"
                     /evalue="1.10E-18"
                     /label="STPH1_RS06580_PKS_KR.1"
                     /locus_tag="STPH1_RS06580"
                     /protein_end="156"
                     /protein_start="4"
                     /score="59.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVSGGTRGIGRALSLRLAALGHRVVALYRGDDDAARRTEKAGDGR
                     IEALRCDLARPQEVRAVCASLTARHGAPSVLVNNAGVNRDRPFLSMTDRDWDTVLATNL
                     SGPFHLTRALAPAMVQAGGGSVVNVASTTAIRPRADGANYCASKAGLL"
     CDS_motif       21939..21992
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS06580_0002"
                     /evalue="3.80E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="STPH1_RS06580"
                     /protein_end="131"
                     /protein_start="113"
                     /score="0.3"
                     /tool="antismash"
                     /translation="LTRALAPAMVQAGGGSVV"
     gene            22396..23208
                     /locus_tag="STPH1_RS06585"
                     /old_locus_tag="STPH1_1320"
     CDS             22396..23208
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017532.4"
                     /locus_tag="STPH1_RS06585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1320"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_153177313.1"
                     /sec_met_domain="PhyH (E-value: 5e-35, bitscore: 120.3,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLTQQQAAEYHERGFLMLESLLDAQEVETLRAAFERDAKVPGPQ
                     VVTEDGGTEVRAVYSSHQRQQEYAGLVRDPRILAPVRQLLCDDVYVYQFKINAKPPFGG
                     DKWAWHQDFLAWRIADGLPAPRQVNIGVFLDDVTEFNGPVIFLPGSHRRGLVREGRSAS
                     ARSEQHLDPDDISLSPGQLAEYVDRHGMTSPKGPAGSVVLFSPEIVHGSSPNMSPFARR
                     LLIATYNDTGNLPRPEGEPRPDYVVCRDTAPLRPLAAPFSQVPCAVAS"
     gene            23205..24329
                     /locus_tag="STPH1_RS06590"
                     /old_locus_tag="STPH1_1321"
     CDS             23205..24329
                     /NRPS_PKS="Domain: PKS_ER (140-305). E-value: 4.2e-12.
                     Score: 37.7. Matches aSDomain:
                     nrpspksdomains_STPH1_RS06590_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012335.4"
                     /locus_tag="STPH1_RS06590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1321"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_205616641.1"
                     /sec_met_domain="ADH_N (E-value: 5.5e-22, bitscore: 76.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.6e-18, bitscore:
                     64.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARAATSAATGRAVVLEEFGKPLSLRTFPLPGPPAGGMVVACGY
                     GGVCGTDLHLCQGHLDIPVPLVLGHEGLGVVRELGPGTDRDAAGTPLAAGDTVMWASSI
                     SCGVCPPCRLHREPTLCERRRTYGVNRALADGPELSGAWADHIVLQPGTAVIKVPDGTD
                     PLAAMSLACAGPTVAHALFERRPVRLGETVVVQGSGPVGLAAAAFAQLAGAAKVVVVGG
                     PAGRLERAADAGIGDVHLDIAGADDPAEVLRRARAAVGGDGADLVIECAGVPAAVGQGL
                     GLARRGGSYLVIGQYTDAGDTTLNPHQIVHRQLDVVGSWAFTGAHLVEYVRLLPALTGR
                     FGLAGLVTPFPLERHADALDAVADGSVIKAVLTS"
     aSDomain        23625..24119
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STPH1_RS06590_PKS_ER.1"
                     /evalue="4.20E-12"
                     /label="STPH1_RS06590_PKS_ER.1"
                     /locus_tag="STPH1_RS06590"
                     /protein_end="305"
                     /protein_start="140"
                     /score="37.7"
                     /tool="antismash"
                     /translation="GAWADHIVLQPGTAVIKVPDGTDPLAAMSLACAGPTVAHALFERR
                     PVRLGETVVVQGSGPVGLAAAAFAQLAGAAKVVVVGGPAGRLERAADAGIGDVHLDIAG
                     ADDPAEVLRRARAAVGGDGADLVIECAGVPAAVGQGLGLARRGGSYLVIGQYTDAGDTT
                     LN"
     CDS_motif       23772..23819
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS06590_0001"
                     /evalue="8.50E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="STPH1_RS06590"
                     /protein_end="205"
                     /protein_start="189"
                     /score="8.9"
                     /tool="antismash"
                     /translation="GETVVVQGSGPVGLAA"
     gene            complement(24388..25215)
                     /locus_tag="STPH1_RS06595"
                     /old_locus_tag="STPH1_1322"
     CDS             complement(24388..25215)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089878.1"
                     /locus_tag="STPH1_RS06595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1322"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_240468963.1"
                     /transl_table=11
                     /translation="MNGGGAGDPRRELGAFLRSRRERLGPADVGLPGSPRRRTPGLRRE
                     EVAELAGVSASWYAWLEQGRVRTSEQVLRSLARALRLNADETAHVLSFVERAAPAGPPP
                     GWVSPNLLSLVESLAPHPAAVLDPHWDLLAWNAGYSGLLTDLARLAPKQRNLLWLVFRW
                     PPARTLLASWESEARSLLGQFRAKAARHPQDGRYAEITGELLHDPDAARWYGRRETAAF
                     HPAVRHFRHPLAGDLRLRYVKLAAVDEPGHHLLAYLPDDRATEEGLELLAGQR"
     gene            25388..26614
                     /locus_tag="STPH1_RS06600"
                     /old_locus_tag="STPH1_1323"
     CDS             25388..26614
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387910.1"
                     /locus_tag="STPH1_RS06600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1323"
                     /product="MFS transporter"
                     /protein_id="WP_164382416.1"
                     /transl_table=11
                     /translation="MDPADSSPTTSAPPPAGPADPASARPATPMPAATLRLLRTAGFVS
                     NFDRFCITPMLLVIGTRLGVPLTTVMLAASGYFLAYGLMQPVWGLASDRLGRVRVMRIS
                     LAGAAVAALASVLAPGATVLIVARVVAGACFAASIAASITYVGDTVPAAVRQRPLSELM
                     TAFALGTAVATVVAGVLAHYASWRVVFALPGLIAAYLVVALRRLPEPPRAEPGALFAPF
                     AVVLRSRWQWYVMAVALFEGAVLLGFLTYLAPALEAQGASAALAGAVTALYGVGSMAAA
                     QLVKRLVGRWTPVRLIVAGGVQMTVAFGCAAADRSVPALVVCALLLGGGWSFMHSTIQS
                     WATALSPAARATGVAMFGVALYVGSALASAVAAGPAQRHAYHGLFLTAAVLTVPLTVAA
                     AVGRARYRG"
     misc_feature    complement(26709..26724)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.1"
                     /tool="antismash"
     misc_feature    26710..26723
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.0"
                     /tool="antismash"
     gene            26791..27756
                     /locus_tag="STPH1_RS06605"
                     /old_locus_tag="STPH1_1324"
     CDS             26791..27756
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387909.1"
                     /locus_tag="STPH1_RS06605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_1324"
                     /product="DUF4129 domain-containing protein"
                     /protein_id="WP_164382418.1"
                     /transl_table=11
                     /translation="MDRGGRTGHRAAPGAVVAVGVVGALAVAALALRPAEGLLHSGRGP
                     LGQWGIVAIGASAAWTAGVWTAVRRLRPRFGAERMDLPPVEERLREAAAPLLLSATAVV
                     GVLALVLHRFSTGDGPPGPPPLATEPVPEPTFATPPPQERPPGSGDHSSLPLRLVLVVL
                     AAVVVVLVVVAVVRRLRRYRLSLPYRPGPLGSTEPQDDDARLLLSAVHSGRRALAGTDD
                     DARAAVIACYAAMEDALAASGVRRQASDSPADLLTRAADAGFAPGPAGPRLTALFREAR
                     YSSHPMDGAHRAAAAAALEEIASLLGDRAPDPVRDEEAER"
ORIGIN
        1 ggcgccgcag agtgtcggac cagtcgccgt cgcccgacca gtacgtgtcc gtacgggcgt
       61 tgacgaacag gccgggggcg gtccggcgga ccgcggcgat cttcgcggcg tgccgggcgg
      121 cgggcccgag ggtgtcctcc aggttgatgc cgacggcgcc gaccgcggcc agttgccgcg
      181 cgaactcccc cacctcgtcg gggtcgtcgc tgaacccgtc ctccgcgtcg acggagagca
      241 ggaagggggc cgagccgagg gtgagggcca gccgcagggt ctcgtcgcgg gtcgccgccg
      301 ccccgtcggg cagcccggcc gccgccgcga cgccgaggct ggtcgtgccg acggcgcgga
      361 agccctgccc ggcgagggcg agcgcggagg cgtggtccca ggcgcacggg aggagcaacg
      421 gctcgccggg gcggtggagc cggccgaacg cggtcacgac aggtcaccca ccgagtcggc
      481 gtagtacacg gactccgtca ggtggacggc gagttcgcgg aagctccagc cctcgccggg
      541 cgagtggtcg agttgctcgt cggtgagcgc gtcgaggcgg ttggcccaga tccgggcgag
      601 ccgggtgagg cggctgcggg cctcgtcgag gtcctcgccg gtgaagcggg cgcggtcggc
      661 gtccgtggtg accgcggagg cgtgccagtg gtcgggctgc gtctcctccc ccgccagccg
      721 ggcctccagt tccgcgaggt ggtcgatcat gtggtcggcc acccggcgga tcgccttgtg
      781 cggggtgtgg acgcgcccgt cgctgtgggc gggccgaccg tcccagcggg tccaggtggc
      841 ggccagggca aggacgtggt cgaccatgcc ggtgaccgcg gcggcgggcg tgcggggggt
      901 cgtgacggtt ggcgtgtggt tcatgtcccg cacgctaggg cccggttggt tcggcgccgg
      961 ccgaagtgtt ccgggggaac acgggtaccc ggtcggcact gtacgtgcac gtcttctcca
     1021 tggaaggtga catggcgagc gaagagagaa gcgaagaccg tccgcggctg cggtggcagg
     1081 acagcctgtg gggcatcggc gggaccgccc tggccgtggg catcggggtc cagctggtcc
     1141 tgcacggcgt gacggcgtgg ccgtcggcct tggtgggcgc ggtgccggcc gccgcctgga
     1201 tcgtgtggtg ggtgcgccgc cggcgggtgc gcgacgccgg aagggtgggt acggaaccgg
     1261 aggacgtgcc cgccatggag cggcggatcc tcaagggcgg gccggcaccc cgggacccgg
     1321 agcggcggcg ggcgatggcg gcgttcgtcg actcgcgtca ggagcggctg cggcgccacc
     1381 gctggtgggc gttccccgtg ctggccctca tcttcttcgg cacgtcggcc ctgtggtacg
     1441 tctccggctc ggtcggcgcc ggaacgatga tgctaggcct cggggtcgtc ttcctgggct
     1501 ggctggcctg gtacaacgcg cgtttcgacc ggcgcttgtc gcagatgcgc ggcaggttgc
     1561 agggctgagc ggccggtagg ggcctcaggt caccagcccg tgccggtagg cgaagacgac
     1621 cgcctggacg cggtcgcgca ggtcgagctt ggtgaggatg cgggagacga aggtcttgac
     1681 ggtctcgggg ctgatcacga gggccgcggc gatctcgctg ttggagagcc cgtccgcgat
     1741 caggcgcagg acctccatct cccggggggt gagcgggatg tcgcgggtcg tgccgccctc
     1801 ggcgggccgg atccgggcgg cgtagcggcc cacgaggcgg cgtgtcacgt cggggtcgag
     1861 gagcgccgcg cccatggcca cggtgcggat gccgtgcagc agccggtccg ggggcgcgtc
     1921 cttgagcagg aagccgctgg cgcccgcgcg cagcgcctcg tagacgtact cgtcgaggtt
     1981 gaacgtcgtg accacgagca ccttgacggg gtgctgcacc ccggcgccgg ccagcagccg
     2041 ggtcgcttcg aggccgtcga ggaccggcat gcggatgtcc atcaccacga cgtccgggcg
     2101 cagttcgcgt gccaggtcga ccccggcctg cccgtccccg cactctccga ccacctccag
     2161 gtcgggctgg gcgtcgacga tcgtcgccag gccggtgcgg atcagtgcct ggtcgtcgca
     2221 gatcacgacc cggaccggcg cgctcatgcc gtgctccccc cgggtatccg ggcccggacg
     2281 acgaatccgc cgccccccgg acggtccgtg ctgaactcgc cgcccagtac gtcgacgcgt
     2341 tcccgcaggc cggccaggcc ccgcccgctg ccgccggggg acgcggcccc cgtgccggag
     2401 ccgtccgtgc ccacttccac cgtgatctct ctttctccgt ggcgcaccag gacggaggtc
     2461 tgggcgccgt ggtcgtactt gagggcgttg gtcagggcct cctgcacgac gcggtaggcc
     2521 acgaggtcgg agctgccggt ggccgccgcc ggggtgccct cctcggtgaa ctccaccggc
     2581 tgcccggccc ggcgcgtctg ctcgaccagg gtgagcaccc ggccgacggg tggcgtcctg
     2641 ggctcggcgg tgccgtggtc ggggttgagg aggtcgagca ggtgccgcag gtcggtgatg
     2701 gcgcggcggc cggtgtcgct gacggcggcc agcgtctcgt cgagccggtc gggtgcggcg
     2761 gtcaggtagc gggccgcctc ggactggacg accatcgccg tgacgtggtg ggtcacgacg
     2821 tcgtgcaact cacgggcgat gcgagtgcgt tcggcggtgc gggcgtcctc ggcgacccgc
     2881 ctgcggcgtt cgtcctccgc ggcgcgcgcg gagcgcatcc acgcgccgac gccccatgcc
     2941 agggcgagga tcaggtagaa ggtcacgtac tcgaccagcg tctcgtcgcc gccgcgcgcg
     3001 ttcagcccga cggccatggc cacgtaggcc agggtgccgg cgatctgcgt ggcacgccgg
     3061 tacttctcct ggtgggagcc ggcgttgatc agcacgatgg ggagcgcggc gcccgcgaac
     3121 aggtggtagc cgcggagttg gtcgagggcg aagccgaccg agaccagggc gaggcagacg
     3181 agtgtccacc ggcgccgcac ggccaggggg acggactgga ggacggccgc caccccggcc
     3241 agcgcgtcgg cggggcgggt cggcaggccg ccgatctccg tgccctgccc ctggagcgag
     3301 ggcaccagcg acgcgaggag cagcagcatc ccgagcggga ggtcccggac cgtgacgtcg
     3361 agccggtgcc accgctccac gatccctcgg cgatcgatca ccggggcagt gtagccgcgg
     3421 agtcgacacc cgcggcacgc cgtcgcgagc cgaacgccac gatgttcccg cgccggtgcg
     3481 ccagccacag gaagaccagg gtgagcagca ccccgaagcc caccgagtac acgctgccct
     3541 cggggccgaa gtcaccgccg gtgagcagct tcgggcccga caccgtggcg tcgagcaggc
     3601 cctcgctgtc gccgttgccg gagaccacgg tgctgaagac gccgcccgcg gcgaagttcc
     3661 agccgaagtg cacgccgatc accagccaca ggttgcgggt ggcggcgtag gcggcggcga
     3721 gcatgaagcc ggcctcgacg gcgatggcca gggcgcccca cagggtggcg tcctcgttga
     3781 gcaggtgcat gaggccgaac acgatgccgg tcaggcccag cgagaggtac gtgccgatgt
     3841 gctcctcgat gatccggaac aggaccccgc ggaacacgac ctcctcggtc gcggcggcgg
     3901 cggccatgaa cccgacgagc ccgatcgcgc cctgcaccga accgagtccg tcgacctcgt
     3961 agtacccgga ggcgaagagg ttcgtgatga cggccccgaa cagtccgaag ccgatcagtg
     4021 ccccccagcc ggccttggcc gcggcgccct cccgggccac gtccagggcc tgccggcgct
     4081 cggtccgccg caccacccag gcgtacacga acaccaccag cgcggccgac gtgagaccga
     4141 ccaccagcgt gagccagtcg ttgtccttca ccgcctggac ggcgatgccg ccgagggcgt
     4201 aggccgccag cacggccagg aactgccaca cgaatctcac gggaactcct tggtagggcc
     4261 cgtgactcga gtgccgcggg ctgccatgga cgctacggat ccggcggccg gagatcgtca
     4321 cctcacggtg gacacctgtg tgtagctcgc acgggggaca agggcccgga gcgcgggtgg
     4381 gctcgtcgta gcctcgtggc atgaccagcg acttcgccga cgccctcgcc tcgggcccgc
     4441 tcgtgctcga cggcgggctg tccaaccagt tggaggcggc cgggcacgac ctgggcgacg
     4501 cgctgtggtc ggcgcggctg ctcgccgacg acccggaggc gatcacgcgg gcccatctcg
     4561 cctacttcga ggcgggcgcc gacgtggtga tcacctccag ctaccaggcc accttcgagg
     4621 gcttcgcccg gcgcggcatc ggcgggcagc gggcggccga actgctggcg ctcagtgtgg
     4681 agtcggcccg ggaggccgcc cgccgggcgc gggtgggccc ggcgggccgg gcgggccgcc
     4741 gccggtgggt ggcggcgtcg gcgggaccgt acggggcgat gctcgcggac ggttccgagt
     4801 accggggtcg gtacgggctc gacgtgggcg agctggagcg cttccaccgg ccccgtctgg
     4861 aggtcctggc cgccgcacgg ccggacgtcc tcgcgctgga gacggtcccg gacaccgacg
     4921 aggcggtggc gctgctgcgg gcggtgcgcg gtctgggcgt gcccgcctgg ctgtcgtaca
     4981 ccgtcgacgg ggaccgtacc cgcgcgggcc ggccgctgga ggaggccttc gccctggccg
     5041 ccgacgcgga ggaggtggtc gcggtcggcg tcaactgctg tgctcccggg gacgtgtccg
     5101 gcgcggtccg gaccgccgcc cgggtcaccg ggaagccggt cgtcgcctac cccaacagcg
     5161 gggaggtctg ggacgcgcgg gcgcgggcct ggcgggggcg ttccctgttc gcgcccgggc
     5221 tggtgcggga gtggcgggcg gccggggccc ggctggtcgg ggggtgctgc cgggtggggc
     5281 ccgacgcgat caggtcgatc gcgtcggcgc cctcttcgtg ctgactcaca gcgagagcat
     5341 cgccaggggc gtgtcccggg tgacctcctg gacgcgtcgc ggggtcaggc cggcccgttc
     5401 gaaccactcg gcgctctgcg tcagccaggg ggtgatgtcc ggctgggacg gctggcccag
     5461 gtcggagctg tagacgaccc tcggcagcag ggtcaggacg tcggcgagat cgctccaggg
     5521 ctggtagccg aggaggtggg tcagggcggt ctgctcggtg aagacctgtt ccgcgccgac
     5581 gagatcggcg aggtccttgc aggtcagccc ggtcatgggg ttggcgggct ggttgagcat
     5641 cagacggggc aggtcgagcc gtacggcctc ctcgatcagc agccgcacct cgtggccgtc
     5701 ggcgtgtccg gtggagacga ccacggggag gtcccgggcg gcgcgcagga gttcacggac
     5761 gtcggggcgg agcgtgccgc tgtcgtcggt gacggtgagc ggacgctggc cgccggcgag
     5821 cagggggtgg gagggggtgc gggtcaggcg gctgcggtgc gcccggccgg tgacggtggg
     5881 caggtggacg atcagccgca ggccgctgtc ctcgccgtgc tggacgacgg cctgttccac
     5941 cgccctgggg tcgaagcctc cggccaggtc gttgaggacg atcgaacccg agaccggcag
     6001 gccctgctgc cgggcctccc acgcctgggc ggcggtggat cccaggtggt tcttgaggac
     6061 gacccagccg ccgtgctcgg cgtagcgcgc ggccgcggcc gtcgcggtgt ggcggcgcac
     6121 atacgcgtcg gggccgcagt ggtagtggac gtcgacgaag cgggcggtcc gcgccgcgcc
     6181 gtcagcggcc gtcatggcgg cccccgtcct cgtcctccca cgggcgcgcg tagccgaagc
     6241 gggcacgtgc cccgtcgagc cggctgccgt cgagcacggc ggcgcggatg cgtgcctcgg
     6301 tgcggtcgac cgcctcggcg cggcgcagga cttctccggc cagcgcggcg ggcacgcgca
     6361 gcgcgccgtt gtcgtcggcg acgatccagt ccccggggtc gaccgtggtg cccgccacgt
     6421 ccacgctcac gcccgtccgg tccaggacga cccggttctt gccgctgacc atggtgacgc
     6481 cggtgctgaa cagggggtag ccggcggcgc ggctctccgc cacgtcgcgc accgagccgt
     6541 ggacgaccgt gcccgagacg ccgcggtgca gggcgacgga gctgagcagg gagccccagt
     6601 tggtgcaggt gaggctgccg ccgttgtcca cgacgacgac ggagccggcc ggtacctcgt
     6661 cgatgtagtc ggccgcgttg cgaaagcccc gggcgtcggg gtccagcggg cggtagcgga
     6721 cggtgaaggc cgggccgcag gcgagggtgc ccggcgtgcg cgggcggatg cccggcagga
     6781 cgcacggcgg ggtgcgcagg ctgtccatgg cgtcggagag ggcggcggtg tccagccgcg
     6841 cgagcctccg gcgcagctcg ccggtgtcgc cggagggtgc ggtggcggtg gtcatgcggg
     6901 gtccttcggg tgggggtggc cggtgaggtg ccgggtgagg gtccaggcgg cgtactgggc
     6961 ggcgtaggcg gtgacttcgg cgccccggtt ggggacggtc agggtgtccg tccgctcgtc
     7021 cgtcccctcg cgcaccgcgc agttgagggc gacggtgccg gtgtacgtcg tccggtctcc
     7081 gccgtcccac cggccggaca gggtgacccg cagggagcgg gagccgtcgc cggtggcgcg
     7141 ggcgcgggcc agttcggcgg cgaagaggcc cccggtcagc cggtcgtcca cgtccaggac
     7201 gacgtcgtgc tcgtccagca cggccgccag ctcctggacg gcggtgcggt cgcggtcggt
     7261 gacgacgtgg cgggccagcg tggcgtcgag gcgccgcgcg aggtccgcgg cgtcctcggg
     7321 cgggcaggtg acgcggatgt cgacgtaggg gtagtgccag cggtaggcgg tcctggccgg
     7381 cccgccgtac tccttgacca gggcgtcgac cagggcggcc gcgtccgcct cgatgacgcc
     7441 gagggtgcgg cggaagaggg tggtggtctc gggcgggcgg gggatgtggg gcaggccgtc
     7501 gcgcagcgac tcctccagca tgggcaggca ttcgcgcggc gggccgggga gcatgaggac
     7561 ggtgctgccc tgcgtctcgg cgcggcagcc ccaggcggtg ccgttggggt tgggcagcag
     7621 ttcggcgccc tcggcgaaca gcgcctggcg gcggttgtcg tcgtggacgg cgacgccgaa
     7681 gcgggtcagg cgggccacga cggcctgcca ggcctcctcc cggtgttcca gcggccggcc
     7741 gagcgcccgg gccacggcgc cgcgggtcac gtcgtcggag gtggggccga gtccgcccat
     7801 gaccacgacg acgtcgtccc ggcccaggca ggagcggacc gcgtcggcga tgccggcctc
     7861 gtcgtcgccc acggtgtgcc gggcgcggac cgggatgccg cgttcggcca gcaggcggga
     7921 ggcgtggccc gcgttggagt cctccaggtc gccgcgcagg agttcgtcgc cgacggtgac
     7981 gacggccgcg gtgggggcct gcgggagcgc gcggcaggcg tcgacgaccg cctcggccgc
     8041 ctcggcggtg gtggccgtgc cgcccaggtc gtaggtgacc cggtcgcgcc ggcgggtgac
     8101 gtgccgtacg gcgtccttga ccgcgcccgc cgcctcggtg aacccgaggt ggtcgagcat
     8161 cagcccgacg gtgaggaacg cggccgtggg gttggcgcgc tgccggcccg ccagggcggg
     8221 ggcgctgccg tgcaccggtt cgaagtagtt gccgttctcg ccgatgttgg cgctgggcgc
     8281 caggccgagt ccgcccatga cgccgccgcc gaggtcggag aggatgtcgc cgaacatgtt
     8341 ctcggcgacg atcacgccga accgctccgg gcgccgggtc atccacaggg cgaccgcgtc
     8401 cacgttgagc acctcgtacg ggatctccgg gtagtcgccg gcgatgtctt cgaggcggtt
     8461 caggacgtac gcgctggagt cgcgcaggac gttgggcttg tcggcgaggg tgacgcgccc
     8521 gtagccgtgg gtccgggcgg tctcgaaggc gaagcgcagg atgcggtcca ggccgtgcgc
     8581 ggtctggagg cggacggagg cggcggcccc ggtgcgggtg gagcggcgga cgttggggtg
     8641 gtcggcgacc agcggccaca gcgcgtcggg cacggggctg aagtccagcc ccgcgtacag
     8701 gccctcggtg ttctcccgca ccacgcagta gcggtacggg gtggtgccgc cgaggtagtt
     8761 ctccactggg cgcaggttgg cgaagaggtc caggcggcgg cggagctgga tgatcggcga
     8821 gacgtaccgc ggtgcgctcg cgcgcagttc gggggcgagt tccgccagtg cctcgccgcg
     8881 cggtttggtg gtggtggcgc cgagcagtac ggcgtcgctg cggtcgatca ggtcccaggt
     8941 gcggtccggg acgggggtgc cctcggcgcg ccagcactcc cagccgatgt cgccgaattc
     9001 gaggtcgagg gggaggtcga gggcgtcgat caccggcaac gcggcgtcca gcacctccgg
     9061 tccgattccg tcgccgggga ggacggcgac ggtcttgcgg ttcatgtgag ttcagctccc
     9121 aggaagcggg tgagggtgtg ccggacgagg tccggccggt cggcgtgcgg gcgcatcccg
     9181 gcccgcggta cggcgacgag tcggtggtgc ggcagcggtc ccgtcgccag gtgttcgcgc
     9241 ccgacgagcc gggaccgttc gccgtacacg tgcagcagcg ggcccgggaa gtcccgtacg
     9301 gggtgccggg cgtcggcgtc gtgcagcagc cgcagtccgg cggccagccg gcgggccgcc
     9361 gccggttcgt cggccgccgt ggggcgggcg ggggctgccg gcgcggcggt gcgggcgggg
     9421 gcgttcggcg cggcgggccg ccggtgggcg gcggcggccg gttcgtcggg tccgcgcacc
     9481 acgtcctcca gcaggcgggt ggccgccggc aggccctcgg cgtcggccgt cgcggcgatg
     9541 cgttcgagtg tggtgttcag ccggtggtcg gcgaccgtgg gtccggagag cagcagcacc
     9601 ttggcccggt gggtccactc ctcgccgagc atgccctgga cgacggcgcc gcccagggcg
     9661 ttgccgacga ggacgtccgg gggcgcgtgc cccgacggac cgtgcgcgcc ggacgccggg
     9721 cccgggttct cccgcggtgc gaggtaccgg gcccagcggt gcacgaggct ccccaggtcg
     9781 tcgccgtcgc gcagcaggga cagggtgtcg tggatcgtga cccggtggcc cgagtcgagg
     9841 aacgggccgg cgatccgccg gaagaacgcg ccgtggtccc accgggcgag aacgggggcg
     9901 aggacgatcg cgtggcgcgg ggcgccgacc ggacccagca cggcgtgggc cgggaccggc
     9961 gccgtgtcgt gcgtgggctc ggacggtggt ccgggccggg tcaccgggcg ccggtggcgg
    10021 tgagttcgcg ggccgccgag aaggcgtccg agatacggcc ctgggggagc ttggcgcgct
    10081 cctcgacgga caggtcgaag tggcccagga ccaggtcggg cagcggcagg gaaggggcgg
    10141 cttccgcgaa ctcgccctcc atgcggtggg cgagggcgag gatccggccc aggtcgtggc
    10201 cctcggtgcg cccgcgccgg ccgaggtagg ccagccactg ttcggtgacg aggttgcccg
    10261 gccccttgcc catgcccagg acggaggagt cgatccacgt cgcccccgct tccacggcgg
    10321 cgatggcgtt ggccagggcc agtccgaggt tgttgtgggc gtgcaggccg atggccgcgt
    10381 cggtcaccga acggaccagg gtcaccagcc gggagacctc gcgcggcagc atgctgccgt
    10441 tggagtcggc caggtagacg acgtcggcgc ccgagtcgcc cgacatggcg gccagttcgg
    10501 ccaggcggcg gccgtcgagc tggctgacgc gggtgatgtt gacggtggtg gtgaacccga
    10561 ggtccacggc ctgggcgagc agggcgagtc cggcctcggg cgcaccggag ggcaggcaga
    10621 agcgcaccat gcgcgcgccc gcctcgtaca tgcgcggcag gtcctcctcg gtgatgttct
    10681 tcgggtgcac gatcatgcac aggtgctccg gcgggacgac ctcggcgagg gcgcgtatgt
    10741 agtcgtccgc gcccagtccg gtccggccga tgcccgggcg cggcttgaac gagccgttgc
    10801 ggtacccgat ctcgatccac tccatgccgg ccgcgacgct ctcccggacg tggtggcgtg
    10861 cgtagtcgag cgggaagtcg aagttgttgc ggtagccgcc gtcgcgcagc gtcacatcaa
    10921 gattgatgac catttctacc cctccatgaa tggcgcatgc agcaggcggg gcgacggccc
    10981 gcgcggcttt ccgcgcgggc cgacaaagaa ttgggaaacc gttcattctg ttgcgggggg
    11041 tcccgatgga cccgctccgc atcaccccgt tgataaaccg cgaagaactt cggtattcaa
    11101 ccagcgtcat gctgaaggaa gttcttcgac acgggacacg ctatcccacg atgcgagcgc
    11161 gaccttaatg cccgggtaaa gaatcaggcg gaggtctctt tacccgcgga cttcccgcgc
    11221 acgcgtgcac tggtttcggt cagcagtttc agccgttcgg gatccgcgtc cgcccgcagg
    11281 gccagggaca tgcgaatggc gacgggctcg ccgtcgaggg gcagcaccgc gacgcggcgc
    11341 gaggagacgg tgccggccgc cgccgggtac atcggaatcc agccgcccgc ccccgcgccg
    11401 atctcggcga gggtctcctg gagaccggtc gagggcgggc cgagggcggg ctcgaagccc
    11461 gccttgcggc aggcgaggac cacggtgtcg aagagcacgg ggttctcggc gcggggggcg
    11521 atgcgcagcg gcaggcgggc caggtcggcc aggcgcagcc ggtcccggcc ggccaacgcg
    11581 tgcgcggcgg gcagcgccac cacgagcggg tcctgccaga ggctgagaag cagcaggcca
    11641 ggggcgcttt cgaggccgcg gacgaaggcc gcgtcgaggc gtccggcacg cacctcttcc
    11701 agccgggtgt gggcgtccag ggtctggaac tcgaagcggg tcccggcgcc ccggtcgggc
    11761 agcgcgtcca ggaagtcgtc gagccgccgg ccgagggcgg agctgatgcc gacgcggaag
    11821 gtggcgtcgc cctgggcggc cagccgccgg gccgtcgcgg cgaaggagtc catcgccctg
    11881 agcacctcac ggccctcggg cagcagtgcc cggccggcgg gtgtgagggt gacggtgcgg
    11941 cccgagcggt cgaagagctc ggcgctcagc tcgcgctcca ggcggcgcac ctgctggctg
    12001 accgcgggct ggccgatatg caggcgttcg gccgcgcggc cgaaatgcag gtcttcggcg
    12061 accgcgacga agtattgaat ctgacgcagt tccacggtgt ccccctctgc ggccggcgac
    12121 ccctttacgg aatatgccga acacaggcgg gtgggggcgc cgcgagggaa atcctcgcat
    12181 accacggagc ggcacctccc ccaggagggc cgctcacggc ggagcgcgac acgacgggtt
    12241 cttcgggtgg cggttcggtg aggatttcgc cgatgcgacg gaaccggtcc ggtccttcta
    12301 ctcggcgacg gcctcctgaa cctccttggg acgctcgccc gcgccggtcg cggcggtcgc
    12361 caccggcggg gcggtcgcgg tgtcgtcgga ccgggggctc ccggtcgcgc gtccttgggc
    12421 cgcgagccac aggaacaggg cgaacaggac gacgcccacc gccgacgcgg ccagcacgaa
    12481 ccagcccagc gcgaggaggt caccggcggg cagcctgctg gtcaggtaga tgccgagcga
    12541 ggcgccgagc agttgcagcg cgcccatcag cccggacgcc gagccggccg tcgtgcggaa
    12601 ggccgtcacc ccggcgctca tcgacagcgg gagcaggaag ccgttgccga aggtcatcac
    12661 cggcatgaag accagcacca gcaggcccca ccgcccgccc gcgccgctca gtcccagccc
    12721 gagcatcagc agcgcgccgg cgaggaagaa cccgtggccg gcccacagca gttcgtcgat
    12781 gcgccgcctg cggaccaggg cgcgcgaggt caggttcccc gccacgtagg cgacggagac
    12841 ggtgatgtag cagtaactgg tcgtctcggt cgccaggccc atcttctgga agaccagcgg
    12901 cgaggcggcc aggtagccga agtaaccgcc gtaggcgacc gcgaggttga cggtgtaggc
    12961 ccagaacagc gggcgggtca gcaggccggg gtagcccttg agcgtggccg ccaagtgctt
    13021 gctgcgccgc tgcggcggca ggctctccgg gatgcgcgcg accatcacga ccagcgtcgc
    13081 cagcccgatc agcgcggtca ccgcgaacgg cgcccgccag gagacgtacg aggtcagata
    13141 gccgccgatc aacggcgcga cggacgggga gacacccacg atcggcatga ccgtggcgaa
    13201 ggtcctcgcc gcgtccttct cctcgtacag gtcgctgatc acggcccgtc cgagcaccat
    13261 gccggacccg gcgccgagcg cctggagcag gcggcccgcc ccgaagacct cgatggtggg
    13321 ggccgccgcg cagaccaggg acgcggcgac gaacaggccg agcccgaaga cgatgacgcg
    13381 cttgcgcccg tacgcgtccg agatcggacc gtagaccgcc tgcgagacgg cgatgccgat
    13441 catgaacgcg ctgaacgtcc actgcacgga cgcgaccggg gcaccgaagg cctgcgcggt
    13501 gtcgggcacg cccggcaggt tgatgtcgga ggcgaacaga ccaccggcgt tcagcgagca
    13561 cagcacggcc agcagcagtc cgtaggacgt ccgcgcgggt ctcggtaccg gtgtcgatgc
    13621 ggttctcatg gcgactctct gcgaaggggg atgccgttcc cggcgggaac gagggggacg
    13681 gttcccggcg ggaacggcgg ctgcgggccg tcagctcctg gcggcgcggg cggcgagggt
    13741 gtccccgccg atcgaccagc tgtcggtggc gatctcctgc accgtcaccc acacgctctc
    13801 cggcttgctg ccggtggcgc tcacataggc gtcggtcagg gcgcgcacca gctcgctctt
    13861 ctgctcggcg gtcttgccgg gggtctgctg cacgtggatc aggggcatga cgtgctccgg
    13921 ggctcgttct ggactgcgga cgaacggcgt acgccccggc gccgtgggcc ggggagtcgc
    13981 tgtggtccaa gtccagcacc gggtgcgggg ccgtccaaga cgcagttcgc tctggccacg
    14041 atcacgaatc gtgatgagac tctgctcggg ggccgcggac gcggccccgt gtcccggccg
    14101 ccggtcaggc cggctgcaac tcctcggcgg cgcgccaggc gtggtcggtg aagcgggcgg
    14161 cctgggggtg ggcaccgtgc gagggatagg tgaggtaggc gggcacggtg ggtgcgccgg
    14221 tcagcggcat gatgcgcacg gagggatgcg tgtagcggcg ggcggcggag acgggtgcgg
    14281 tgcccacgcc gagccccacg gcgacctgct ccagccattc gtcgaagttg cggcactcgg
    14341 agccgaccac aggccggctg ccggccggcc acatgtcggg gaaggtggtg ccgctgacgg
    14401 tgttgacgat cagcggcagc ccggccagct ccgcccagtc gagttcgctg cgctcggcca
    14461 gcttccagcc ggcggggacg gccgcgctgc gcggctcctc gtagaggagg acaccccgca
    14521 gccccttcgg cagcggcgtg ctgcgcagca gggccacgtc cgcccggccg gtgtcgagtc
    14581 cggcccgggg ggtgtcgcag cggatgaact cgaccccggt gccggtcgcc tccgtgaacc
    14641 gggcggcgag ccgcgacagg ccctcgggca gtccccagct gaacccgacg cgcagtgtgt
    14701 ccccgttgcg caggtcggtc agcgcggagt ccagttgacg caggagcggg acgacggctt
    14761 cccgcagggc ctctcctttc ccggtgagtt ccgttctgcg ggtggtgcgc tcgaaaagcc
    14821 gcacgcccaa agactcctca agtgtcctga tattgcgcgt cagggtcggc tgggcgagat
    14881 gcagccggtg tgcggcggcc gtgaaacccc cctcctcggc aacggccagg aagcaacgga
    14941 ggtgacgcag ttcgacattc attcgttgag cgtataggtg gttcggtaac gtcatttctc
    15001 ccacaccttg cgcggcgtct agtcttcgtg gtgccgccgg gcggaccgtg cgctcgacgg
    15061 caacggggtt actgtgcagc gatattgacg cgcaccgtca atcgacatgg cgcaaagatc
    15121 gaccaaaggg cgagtaaagg caccggcgtc ccggccgtcc tgcggacgcg atgtccgcca
    15181 cccccgatgg ttattccctc aactatttcc gttcggcttc ccggcgcatt gccggggcct
    15241 cggccgcgtc accgggtccc ggcacggcgc gccgtccgcg cgccctgccc gaatgcccgc
    15301 tccgccaccg taaacactga gaaggattgt gctgtgccgg tcatcaccat gcgcaacggt
    15361 cccttggaac acgtcgtcat cgacggcaat tccgacctct cccccctggt cttcctgcac
    15421 ggcggactcg gctgcctcgc ggcctgggga cgattccccg cccagctcgc cgccgccacc
    15481 ggacgccgcg ccctcgtcta ctcccgccac ggccacggcg gcagcggacc cgacccgctc
    15541 ccccgcaccg accgctacat gcacgagcac gcccacgagg tgctgccgga gctgctcgac
    15601 gcgctgggca tgcgccgccc cgtcctggtc ggccacagcg acggcgcctc catggcgctg
    15661 ctgcacgcgt cggcgcaccc ggtacgggcg gtcgtcggga tgggcccgca cctgtacttc
    15721 gaggaggaga accgccgggg catcgagaac gcccgcgcct cctacgcggc gggtccgctc
    15781 gcccggaagc tggccatggt gcacgacgac ccccgagggg tgttcgaccg ctggagcggg
    15841 gtctggctgt cgcccgcctt ccgcgactgg tccatcgagg acgaactcga cgtcaccgca
    15901 ccggtgctgg cgatccaggg cgacgcggac gagtacggca ccctggccca ggtcgacgcg
    15961 gtcgaacgcg cggtggacgg cccgttcgta cgcctggtcc ccgaaggctg cgaccactac
    16021 ccccatctgg tccggcccgg actcgtcgtc gacgccgtcc gcgggttcct cgccgaaccc
    16081 gccaccttcg ccgccgcccc ctccgcgcgc accgcgcata ccgcgcacac cgaccggata
    16141 ccgtccgcgg gagccggccg gtgaccgcga cgaccgcgcc ccgcctcgac gccctgctgg
    16201 cccgcgccgc acgcgaccac cccgggcgca ccgccctgga gggcgccggc gagagctgga
    16261 cgtacgcccg gctggagcgg gccgtcgacg cgctggccgc ccggctggcc gccaccggcg
    16321 tcgcccccgg tgaccggatc ggcgtccacg cgcccaagac ccccgccacc gtcgtcgccc
    16381 tgtacgcggt gctgcgggcc ggcgcggtgg ccgcaccgct ggacaccgcg gacccgccgg
    16441 agcgaaccgc ccggatgatc cgcaacgcgg gtctgtcggc gctgctgacc gtcgaccgca
    16501 ccctgaccgg ggcccgccgg gccgtcgtcc gcgcccgcga cggccgcacc cgcgacgacg
    16561 cgccggccac cgcggaggcc ctcgaccacg gcctgcacct gctgcgttgc ctcggccccg
    16621 acgagcggcc cgcgccactg cccccgccgg ccgaccgggg cggctacatc ctgttcacct
    16681 ccggcagcac cggctggccc aagggcgtcc tgctctcgca cgagaacgtc gcgcactacg
    16741 cgctgtgggc cgcgcgcgag ttcgggctca ccccggacga ccggatcggc tcgcaggccg
    16801 ccctcacctt cgacctgacc accttcgacc tgttcagcgc cgccgccgcg ggagcctgta
    16861 cggtcctgat gccggacccg ttgcgggtct tcccgcggga cgtcgtcgcg tggctgaccg
    16921 aacagcgcgt caccgccttc atggccgtac cgtccctcta ccacgccatg ctccagcagg
    16981 gcggtgtcgc ggacgccccg ccggccaccc tgagaatcgc ggccttcggc ggggagccgt
    17041 tcgcccccga actgctcgag cggtacctga ggctgttcga cggggtgccg ttctacaacc
    17101 tgtacggccc caccgagacc aacgcctgca cctactaccg ggtgccggcc gactggacgg
    17161 ccggccggga actgcccatc ggccggggca tcgacggcgt ccacgtcgac gtgctcgacg
    17221 acgagggccg gcccacggac ggcgagggcg agatccacat cgcggggccc gtcgtcttcc
    17281 agggctacct gcgcggcggg gcgcccgagg accccaccgt caccgccgtc ttccgcgacg
    17341 gcgtcgcccg ccgcgcctat gccagcggtg acctcggccg gatgcggccc gacggacagg
    17401 tgctgctgcg cggccggcgc gaccaccagg tcaagcggcg cggccaccgc atcgatctga
    17461 tggacgtgga gaacgccgtc ctggagctgg agcaggtggt caccgccgcc gtcgtcgcca
    17521 aggagggctc ccacggcccg gacggcccgg acggctcccg caccggcgag atctgggcct
    17581 acgcgcagac ggacgccacc gaacacgagg tcctggccgc gctgcgcggc gtactgccca
    17641 agcggatgct gcccgaccgc gtcgtaccgc tcaccaccct gcccaccacc accagcggaa
    17701 aggtcgaccg ccgcgccctg agcggcacga ccggccccgc gcacccggag gacgtcaccg
    17761 tatgaacagc gtcgaagaac tctgcgccct gatcggcagc cgcatcacct ggggccccgg
    17821 cgaggacgcg agctccctga ccgccgacac cccgctcctc gagatgggcc tggtcgactc
    17881 gctggcgatc atggagatcg tcgcggcgct cgacaaggag gccggcgtca ccctgcccga
    17941 caccgagatc gtcgccgcca acttccgcag ccccaaggcg ttgtgggccg cgatcgagag
    18001 cctcgccgtc gagggccgcc catgagcgcg acgaccatcg cggcaccgcg ctcgtgcgca
    18061 ccggagaccg aagcggtcgt cgacgcccac cgggacctgg ccgcgccggt ggtggagcgg
    18121 atccgggacg cggacttcac cgccgggtgg cgggcgatgg ccgacctcgg tgtgctccgc
    18181 ctcgccccgc ccgacgccgc ggcgcccgga ccggtcaccc gcgcgctcgc cgtgatcgag
    18241 ggcatcgggc tggcgggcgt cgacccgggc ctgtgctacg cgctggcctc ccaggtcttc
    18301 gggatgcagt tcccgctgcg ggccacgctc ccggcagcgg cctgggacgc ggtcgccgac
    18361 gtccaggacg gccgatccct gctctgccac gcgctgaccg aacgcggggg cggcagcgac
    18421 ccgttctcga tggagacccg cgccgtgcgc gacgccgacg gcttcgtgct cgacggcgcg
    18481 aagacgttca tcaccgcagc gcccgtggcc gaccgggcga tcgtcttcgc ccgtaccgcc
    18541 caaggacgct caccgttcgc gctgtcggcg ttcctcctcc ccctcgatct cccgggggtc
    18601 cggcgcggtg agaccttcgc caagaccgcg ctgccgaccg tgccgatggg ggagctggtc
    18661 ttcgagggcg cccggctgcc cgcgggcgcg ctgctcggcg aggagggttc cgggctggcg
    18721 gtgatggcct cgaccaccgc ctgggagcgc tccgtcatcc tcgggtacgc cctcggcccg
    18781 atgcaccgtc tgctgacgcg caccgtcgag tgggccgccg gacgggacca cttcggccgg
    18841 cgcatgggcg ccagtcacca ggtcgccgca cgcgtcagtg acatggccct ggcgctgcac
    18901 cgctcccgcg tccagctcta cgcgatggcc gcccggctcg acgccggcac acccgcccgg
    18961 cagctggccg ccgaggccgc cctcaccaag atctccgtgt ccgaggacta cgtgcggatg
    19021 accgagcacg ccaccgcgtt gtccggagtc cgggccttcc tgcccggctt cgacctcgcc
    19081 gcggacctgt cgagccccat ggcggccctc acctacgccg gtccgaacga cttgctgcgg
    19141 gtggccgtgg cacggcaact cggcctgccc gtcgagaact gacgggacga cggcccttca
    19201 cccgtcaacc ggccgatcga cacccgaccg gccggcatcc gaccggcccg acacccgacc
    19261 ggccggcatc cgaccggccc gacacccgac cggccggcat ccgacccggc cgggaaccgg
    19321 ccgatcgaga cccgaccggc cgacgaccca cccaccggcc gggaaccgac cccccaagga
    19381 catcgatgac gctgccgacc cacttcgacg atctcctcaa actcgccgcc gacaccggct
    19441 ccgcgatcgc cccgctcgcc gccggcaccg acgccgcgga cgacgacggc cacgaggcct
    19501 accgcgtcct gcgcgagtcc gggctgctcg ccctgctcgt gccccgggaa gccggcggcg
    19561 ccggcctcgg cttcggcgac tactggcggg tgctggccga actcggcgcg caccacggcg
    19621 ccgcggccct cggcttcaac atgcaccacg tcgtgatcgg cgcgctcgcc gaagccgccg
    19681 ggacccggct gtcccctgcc gccgacgcct tccagacctg gatgctgggc gaggtggtgg
    19741 acgggcgcaa gatgttcgcc tccgccacct cagaggcggg acgcggcgcg aagctccgcg
    19801 gcatgcggac ccgctaccgc cgctccgacg acggcacgca ctacgtcctc aacggcagga
    19861 aggacttcgt gtccctggcc ggcgccgccg actactacgt cgtggccgcc gccgacgggg
    19921 acgccgagga gaccgccgag gtctcgcact tcgtcgtcgc cgccgacgac ccgggcgtcg
    19981 gcttcggccc ggtgcggcac atgtcggcga tgtacggcac cagcaccgcg ccgatgacgc
    20041 tggacgaggt ggtcgtgccc cgctcccgcc tctacctcgg cgtcgagggc atgtccctgt
    20101 tcaaggtggt gcgcgagccc cactggatgt tcgcgggcta caccggcgcc tacctgggca
    20161 tggcggaggc cctctaccgg cacaccgtgg accgtgtcac cgccgccccc ggccgcgccg
    20221 gctcacccgt cgtgcagcag gaactgggcc ggatgtccgc ccgtctgcgg gccgcccgcg
    20281 ccctcgttca cgaggccggt gacctggtca ccgcggaacg cggcagcctg gaggccaacg
    20341 ccatggtgca cgccgccaag tacgtcgtgg gcgagaccgg cccgcgactc gcccaggacg
    20401 cgctcaggct gtgcggctcg gccgccgtca gctgcggtca gacgctggaa cggctgatcc
    20461 gcgaggtcca gttcgcgcac gtgatgccgg ccaagccgca cgagtgcctg gagtacctcg
    20521 gcaaggccgc gaccggcgtc aacctctacg acgcccggac cttctcgtgg tgacccccgc
    20581 gagcaccacc gcctcgatgc cccccgcgcc ccgtgccggg gacgaacacg ccgtgccgca
    20641 cgacgccttc cgggccctga tgggctcgca ccccggcggg gtcgccgtcg tcaccacggc
    20701 cgacgcgcgg ggcacaccgt acggcttcac ctgcaccgcg ctgtgctccg tctccctcga
    20761 tccgccgcag ttgctggtgt gcgcggcggc cggcggtagc accctgcccg tcctcgccgc
    20821 ccgcggggcc ttcaccgtca acctcctgca cggcagcggg cgacgcgcgg cccaggcgtt
    20881 cgccggtccg gccgccgagc ggttcaccac cgtcccctgg cggcccgggc tgctcaccgg
    20941 actgccggta ctgccgcagg acgcccacgc gaccgccgag tgccgcgtcg cgcggacggt
    21001 cccggccggc gaccacacca tcgtgatcgg cgaggtcctg cacaccgaga cccacgtccc
    21061 ggccgccgag gccgcgcccc tgctgtacgg catgcgccgc tacgcgacct ggccggtctg
    21121 acccggccgc cccggcccgc accgtcccgt ccgtctcccc cgccccgtga aggagtccgc
    21181 atgtaccgca ccctgatgaa gtcgaagatc caccgcgcca ccgtcaccca ggccgacctg
    21241 cactacgtcg gctcggtcac cgtcgactcc gacctcatgc acgccgccgg cctgctcccc
    21301 ggcgagaagg tcgacatcgt cgacatcgac aacggcgccc ggctgtccac gtacgtcatc
    21361 gagggcccgg ccggcaccgg cgtcctcggc atcaacggag ccgcggcccg gctcatcagc
    21421 cccggcgacc tcgtcatcct catcgcctac gccgccatga ccgacgagga ggccgcctcc
    21481 ttcgttcccg acgtcgtgtt cgtcgacgag cacaacgccg tcgccggcct gggctcggac
    21541 ccggccgagg tgcccgcggg ctcgggtctc aagcgcggcg acctcgtcgc cgaggtgtca
    21601 tgaccctcgc cgtggtcagc ggcggcaccc gcggcatcgg acgggcgctg agcctccggc
    21661 tcgccgccct cggccaccgg gtggtcgccc tctaccgcgg tgacgacgac gccgcgcggc
    21721 ggaccgagaa ggccggtgac ggccggatcg aggcgctgcg ctgcgacctg gcccggccgc
    21781 aggaggtccg ggcggtctgc gcgtcgctca ccgcccgcca cggggcaccc tccgtgctcg
    21841 tcaacaacgc cggtgtcaac cgcgaccggc cgttcctgtc gatgaccgac cgggactggg
    21901 acacggtcct ggccaccaac ctctccggcc ccttccatct gacccgcgca ctggcccccg
    21961 cgatggtgca ggccggcggg ggcagcgtcg tcaacgtcgc ctccaccacg gcgatccggc
    22021 cccgcgccga cggcgccaac tactgcgcga gcaaggcggg cctgctccag ctcaccaggt
    22081 gcctggccct cgaactcgcc ccgcacgtcc gggtcaacgc cctgctgccc gggttcaccg
    22141 acaccgagga ggtgaccgag cgctaccgcc tggacgaccc ggaacggctc ggcgccgtcc
    22201 tggacaccat tccgcgcggc aggctcggca cggccgagga catggccgac gccctggagt
    22261 tcctggtgag cgcgcacagc ggctacgtca gcgggcagca actcgtcgtc gacggcggcc
    22321 acttcatggg atgacctccg cattgtcccc cgtccccccg tcctccgtcc cccgaccaac
    22381 caggagaaga agcgcatgcg actgacccag caacaggccg ccgagtacca cgagcgcggc
    22441 ttcctcatgc tcgaatccct cctcgacgct caggaggtgg agacactgcg cgccgccttc
    22501 gagcgcgacg cgaaggtccc cgggccgcag gtggtgaccg aggacggcgg cacggaggtc
    22561 cgcgccgtct actcctcgca ccagcggcag caggagtacg ccggactggt ccgcgacccg
    22621 cggatcctgg caccggtgcg tcaactgctc tgcgacgacg tctacgtcta ccagttcaag
    22681 atcaatgcca aaccgccgtt cggcggcgac aagtgggcct ggcaccagga cttcctggcg
    22741 tggcgcatcg ccgacggcct gcccgccccg cgccaggtca acatcggcgt cttcctggac
    22801 gacgtcaccg agttcaacgg cccggtcatc ttcctgcccg gctcgcaccg gcgcggactg
    22861 gtccgggagg gccggtcggc gtccgccagg tccgagcagc acctcgaccc ggacgacata
    22921 tcgctgtcgc cggggcagct cgcggagtac gtggaccgcc acggcatgac cagcccgaag
    22981 ggtccggccg gctccgtcgt gctgttctct ccggagatcg tgcacggctc gtcccccaac
    23041 atgtcgccgt tcgcacgccg gctgctgatc gccacctaca acgacaccgg gaaccttccg
    23101 cggccggagg gcgagccccg tccggactac gtggtgtgcc gggacaccgc gccgctgcgc
    23161 ccgctggcgg ccccgttctc ccaggtgccg tgcgcggtgg cgtcgtgacc gcccgcgccg
    23221 cgacgtccgc cgccaccgga cgcgccgtcg tcctggagga gttcggcaag ccgctgtcgc
    23281 tgcggacgtt cccgttgccc gggccgcccg ccggcggcat ggtcgtggcc tgcggctacg
    23341 gcggtgtctg cgggaccgac ctgcacctgt gccagggcca cctggacatc ccggtccccc
    23401 tcgtcctggg ccacgaggga ctgggtgtcg tacgggagct ggggcccggc accgaccggg
    23461 acgccgccgg gacaccactg gcggccggtg acacggtgat gtgggcctcc tccatctcct
    23521 gcggggtctg cccgccctgc cggctgcacc gtgagccgac cctgtgcgag cggcgccgca
    23581 cctacggcgt caaccgggcc ctggccgacg ggccggagct gtccggggcc tgggccgacc
    23641 acatcgtgct ccagccgggc accgccgtga tcaaggtgcc cgacggcacg gacccgctgg
    23701 ccgccatgtc gctggcctgc gccgggccca ccgtggcgca cgcgctgttc gagaggcggc
    23761 cggtgcggct cggggagacc gtggtggtgc agggcagcgg tccggtgggg ctggcggccg
    23821 ccgccttcgc gcagctggcc ggggccgcga aggtggtggt cgtcggcggc ccggccggcc
    23881 ggctggagcg ggccgccgac gccggtatcg gtgacgtcca cctggacatc gcgggtgccg
    23941 acgaccccgc ggaggtcctg cgtcgggcac gggccgcggt gggcggggac ggcgccgacc
    24001 tggtgatcga gtgcgccggt gtgccggccg ccgtcggcca gggcctgggc ctggcgcgcc
    24061 ggggcggcag ctacctcgtc atcggccagt acaccgacgc cggggacacc acgctcaacc
    24121 cgcaccagat cgtccaccgg caactcgacg tggtcggttc ctgggccttc accggtgccc
    24181 atctcgtcga gtacgtacgg ctgctgcccg ccctcaccgg ccggttcggc ctggcggggc
    24241 tggtgacgcc gttcccgctg gaacggcacg ccgacgcgct cgacgcggtc gccgacgggt
    24301 cggtgatcaa ggccgtactc acgtcctgac gccgcccgtc ccggtgcacc cgacggcccg
    24361 gcagccgccc cccgcgcggc cgggccgtca ccgctgcccg gcgagcagct ccagcccctc
    24421 ctccgtcgcc cggtcgtcgg gcaggtaggc cagcaggtgg tggccgggct cgtccacggc
    24481 ggcgagtttg acgtagcgca ggcggagatc accggccagc gggtgccgga agtgacggac
    24541 cgcggggtgg aacgccgccg tctcccggcg gccgtaccag cgggcggcgt ccgggtcgtg
    24601 cagcagctcc ccggtgatct cggcgtaccg gccgtcctgc gggtgccggg ccgccttcgc
    24661 ccggaactgg ccgagcagac tccgcgcctc ggactcccaa ctggccagca gcgtacgggc
    24721 gggcggccag cggaacacca gccacagcag gttgcgctgc ttgggcgcca gccgcgccag
    24781 gtcggtcagc agtcccgagt agcccgcgtt ccaggccagc aggtcccagt gcgggtcgag
    24841 caccgcggcc ggatgcggtg ccagcgactc gaccagcgac agcaggttcg gcgacaccca
    24901 tcccggcggc ggcccggccg gcgcggcccg ttcgacgaag gacagcacgt gcgcggtttc
    24961 gtcggcgttc agccgcaggg cccgcgccaa cgaccgcagc acctgctccg acgtacggac
    25021 ccggccctgc tccagccagg cgtaccagga cgcgctgacg ccggccagct cggcgacctc
    25081 ctcgcgtcgc aggcccgggg tgcgccgtcg cggtgagccg ggcagcccca cgtcggccgg
    25141 cccgagccgc tcccggcggg agcgcaggaa ggctcccagc tcgcgccgcg ggtcgccggc
    25201 tcccccgccg ttcacgtcct cggtcctcct cggttctccc cgcgccaccg gcccgggccg
    25261 gcgcgacgca ccgcgcccca ggctgtgagc aagggtaatc ggctgcgggg ccgggcgggc
    25321 cgaccgcggt gatgagctgg acacgccggt cggaccgtcc ggcgaccacc acccgaggag
    25381 cactcccatg gacccggccg actcgtcacc gaccacctcc gcaccgcctc cggccggccc
    25441 cgccgacccg gcctccgcgc gcccggcgac gcccatgccc gcggccaccc tgcgactgtt
    25501 gcgcacggcc gggttcgtca gcaacttcga ccggttctgc atcaccccca tgctgctggt
    25561 catcggcacc cggctcggcg tcccgctgac cacggtcatg ctcgccgcca gcggctactt
    25621 cctcgcctac ggcctgatgc agccggtctg gggcctggcg agcgaccgac tgggccgggt
    25681 gcgggtcatg cggatctccc tggccggggc cgccgtcgcc gcgctcgcct cggtgctggc
    25741 gcccggcgcg acggtgctga tcgtggcgcg cgtcgtggcc ggggcgtgct tcgccgcgtc
    25801 catcgccgcg tccatcacct acgtcggcga cacggtgccc gccgcggtcc gccagcggcc
    25861 gctcagcgag ctgatgaccg ccttcgcgct gggcaccgcc gtggccaccg tcgtcgccgg
    25921 ggtactggcc cactacgcga gctggcgcgt ggtcttcgcc ctgccgggcc tgatcgccgc
    25981 ctacctggtc gtcgccctgc gccggctgcc ggaaccgccg cgcgcggaac ccggcgcgct
    26041 gttcgccccc ttcgccgtgg tcctgcgctc ccgctggcag tggtacgtca tggccgtcgc
    26101 tctgttcgag ggcgccgtgc tgctgggctt cctcacgtac ctcgcgccgg cgctggaggc
    26161 ccagggtgcc tcggccgccc tggccggtgc ggtgaccgcg ctgtacggcg tgggctcgat
    26221 ggccgcggcg cagctggtca agcggctggt cgggcggtgg acgccggtcc ggctgatcgt
    26281 ggccggcggg gtgcagatga cggtggcgtt cggctgtgcc gcggccgacc ggtcggtgcc
    26341 cgcgctggtg gtgtgcgccc tgctgctggg cggcggctgg tcgttcatgc actccacgat
    26401 ccagtcctgg gccaccgcgc tgtccccggc ggcccgtgcg accggggtcg cgatgttcgg
    26461 ggtggccctc tacgtcggca gtgccctggc cagcgccgtc gccgccggtc ccgcgcaacg
    26521 ccacgcctac cacggcctgt tcctcaccgc ggcggtgctc accgtcccgc tgacggtggc
    26581 cgccgccgtg ggccgcgccc gctaccgggg ctgaccggca cgggccgccg ccgggagcgc
    26641 ccgcggtcga tcgccccggg cgcggaggcg ctgccccgga ggccggtgcg gcatgtgcca
    26701 agatagcgct gaacaggcgt tcgggggcga cgggttcgac ggggcaacgg cttcgagggg
    26761 ttcgacgggg caacgggggg agcgaacggc atggatcggg gcgggcggac cggacaccgc
    26821 gcggcgccgg gggcggtggt cgccgtcgga gtcgtcggcg ccctggcggt cgccgcgctc
    26881 gcgctgcggc ccgcggaggg gctgctgcac tccggccggg ggccgctcgg ccagtggggc
    26941 atcgtcgcga tcggggcgtc cgccgcctgg acggcggggg tctggacggc cgtccggcgc
    27001 cttcgccccc ggttcggcgc ggagcgcatg gacctgccgc cggtcgagga acggctgcgg
    27061 gaggccgccg cgcccctgct gctctccgcg acggccgtcg tcggcgtact ggccctggtc
    27121 ctgcaccggt tctccaccgg cgacggcccg cccggcccgc cgccgctggc gacggagccg
    27181 gtccccgaac cgacgttcgc cactcccccg ccccaggagc gcccgcccgg ttcgggggac
    27241 cattcctccc tgccgctgcg tctcgtgctc gtcgtgctgg ccgcggtcgt cgtcgtgctc
    27301 gtcgtggtgg ccgtcgtacg gcggctgcgc aggtaccggc tgagcctgcc gtaccgtccg
    27361 ggcccgttgg ggagcaccga gccgcaggac gacgacgcgc gactcctgct gtccgccgtg
    27421 cactcgggtc gccgcgccct ggccggcacc gacgacgacg cccgggccgc cgtcatcgcc
    27481 tgttacgccg cgatggagga cgccctcgcc gcgtccggtg tgcggcggca ggcctccgac
    27541 agtccggccg acctgctcac ccgtgccgcc gacgcgggct tcgccccggg cccggccggg
    27601 ccgcgcctca ccgccctctt ccgcgaggcc cgttactcct cgcacccgat ggacggcgcg
    27661 caccgggcgg ccgcggccgc cgcgctggag gagatcgcgt ccctgctcgg ggaccgggca
    27721 ccggacccgg tccgggacga ggaggccgag cggtgaaccg gttcc
//
