LOCUS       NZ_WHZR01000001        10216 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. OM5714 A912_AS4_SC1_R2, whole genome shotgun
            sequence.
ACCESSION   NZ_WHZR01000001
VERSION     NZ_WHZR01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. OM5714
  ORGANISM  Streptomyces sp. OM5714
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M.
  TITLE     Whole Genome Sequence of the phthoxazolin producer Streptomyces sp.
            OM5714
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2019) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2017
            Assembly Method                   :: Newbler v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010993835.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:48:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,730
            Genes (coding)                    :: 7,557
            CDSs (with protein)               :: 7,557
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 7, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 7, 5 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 58 of 173
            Pseudo Genes (incomplete)         :: 139 of 173
            Pseudo Genes (internal stop)      :: 18 of 173
            Pseudo Genes (multiple problems)  :: 36 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:03:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 420879
            Orig. end                         :: 431095
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHZR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(444..2930)
                     /locus_tag="STPH1_RS01970"
                     /old_locus_tag="STPH1_0394"
     CDS             complement(444..2930)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389404.1"
                     /locus_tag="STPH1_RS01970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_0394"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_164381116.1"
                     /transl_table=11
                     /translation="MSHKRCNGDVVEEGTAERGPRALRAEGALKAIAAAPGPEERLRGI
                     LEQTLVFAGASLAALYTPGDDRDLLCLVASAGVPRTLYGVRDSYPAEGGSPVADAHRGG
                     ETVWIGPEEFAGSAESRHVPSSGFSLAVLPVRGDGGGCLLVLTERPDGFDADDRECLGL
                     IAGAMTCPAPAEAVGTPESGALQPDAFTLAMDTGRAEVGDDILRLFGLAPGEFDGKVET
                     LLGLTVPEDLPSLMSVTESDHMTIGERELEFRVLQPTGPPKWLRLSGRLLPGGDGRPAR
                     LVGTVADASTLRPDVTDVARVQRLAAALATAGTVRDVSQAVVAALRRPLRADRIALAEL
                     ENDRLVVTVLDPPDPESWPELWRLEWRTEWPDAPVRAMPTLAAALREGRARIWPAGTGD
                     LEPALADVGPGGLAVLPLPAGGRVAGACLIGWDAPHDFGPDERALLTASAGLAGQALMR
                     AHAFDAEHELVGMLQRQLLPRRLPKLPGAVAVARYLPSTAGLELGGDWYDVIPLPDHHV
                     ALVIGDVQGHSAGAATLMGQMRTALRAYAVEGHPPDVVVSHANRLLTGMETDLFATCVY
                     VDLDMEEGSAWCVRAGHLPPVLRHPDGSTEIAEVEGGPPLGVVTQADFPMSPLRLRPGT
                     LIALTTDGLVETPESDIDEGMDRFAHALAVSAPGHLGLVADALLGNARRNDDVALLLVR
                     YDGMALRPLRESWSVWRLPEAVRHARRFTRRTLRSWDVPDDTVDGVLLIVSELVTNALV
                     HTDGKVRLDLTLISGRLRVAVADASPRTPVKPTSIGWEATGGRGILLVEAMSATWGTLP
                     VSGGKQVWSEIPVGGA"
     gene            complement(3132..4394)
                     /locus_tag="STPH1_RS01975"
                     /old_locus_tag="STPH1_0395"
     CDS             complement(3132..4394)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978109.1"
                     /locus_tag="STPH1_RS01975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_0395"
                     /product="S1 family peptidase"
                     /protein_id="WP_164381118.1"
                     /transl_table=11
                     /translation="MSHKRIPKRRAAMAAGGVVALGAAAILLPNANASQDGGSSDEAAA
                     APRTLKSADASDLATRLAGLLGDTFAGSYYDSGAQRLVVNVVPGQDDRVVAQAKQAGAE
                     VREVDNSMGELRSGARTLKSEASIPGTSWAIDPRTNRILVTADSTVTGDRWDRLESTVE
                     SLGSGMATVRKSAGTFKTFASGGDAIFGGGARCSLGFNVTAGDGSPAFLTAGHCGVAAD
                     QWSDAQGGQPIATVDQAVFPGEGDFALVKYDDPATGAPSEVNLGDQTLPISRAAEAAVG
                     QEVFRMGSTTGLADGQVLGLDATVNYPEGTVTGLIQTDVCAEPGDSGGSLFTRDGLAVG
                     LTSGGSGDCTVGGETFFQPVTTALEAVGATLGDAGAGAGAGAGAGDAGEGAGGGDAGDA
                     GAGAGAGDAGVGGDDGSGPTG"
     misc_feature    complement(4970..4983)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.26"
                     /tool="antismash"
     gene            5001..5216
                     /locus_tag="STPH1_RS01980"
                     /old_locus_tag="STPH1_0397"
     CDS             5001..5216
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="STPH1_RS01980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_0397"
                     /product="hypothetical protein"
                     /protein_id="WP_007389398.1"
                     /sec_met_domain="strepbact (E-value: 2.1e-37, bitscore:
                     126.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETVEISDADLDNVSGGLNVNAVGTVTGLVDGIAPVSGL
                     VNTVVGTVEGATGLNTAPVTGLVAGL"
     misc_feature    5353..5371
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.54"
                     /tool="antismash"
     gene            5370..6176
                     /locus_tag="STPH1_RS01985"
                     /old_locus_tag="STPH1_0398"
     CDS             5370..6176
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="STPH1_RS01985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_0398"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_164381120.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPEELDLPVRFARPQGWLVLSVTVVAMAAASVW
                     AVGGSVTSTVSAPAVLTHGQGSYLLQSPVSGQVTAVLARPGQRLGADAPVLKVRTAKGE
                     TVVRTVDAGRVSALAATVGQIIGTGANVASVEKVAHADDPLYATVYVPAENAAAIPAHA
                     SVDLTVQSVPTQQYGVLHGEVKSVDRSAQSAQTIGAFLGDSALGEQFTEDGRPVAVTVR
                     LETSTSTQSGYEWSSADGPPFELTSMTLASGSIRLADQRPVDWLLP"
     gene            6173..8392
                     /locus_tag="STPH1_RS01990"
                     /old_locus_tag="STPH1_0399"
     CDS             6173..8392
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="STPH1_RS01990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_0399"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_164381122.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2e-39, bitscore:
                     133.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAQETRGRRRAAPPRRSVPKSRAKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARSYGFTAKGMQMDLAALAEVTA
                     PAILFWEFNHYVVYDGMGRRFGRRGVFINDPGKGRRFVSLEDFDGSFTGVVLTMEPGDG
                     FTRGGRKPGVLGAMPARLRGTAGTLPAAVLASLLLVAVGAAVPALSRTYIDMFLIGGQT
                     SLLGVLFASMGACVLLTVVLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTFVGVGVALLNIL
                     AMRVVIRLRATRTAKLRADTARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSGLILWIGGMRAVEGHISVGLLVAFQALVVRFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFRADPLYDRPGGDSTRRLHGHVELQNVSFGYNPL
                     DKPLLSGFDLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWDGVIRVDGQRLDDIPRG
                     ALASSVSFVDQDVFLFEGSVRDNVALWDPSIPDDAVVDALKDAALYDVVMRRPGGIHSP
                     VEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETELVVMDNLRRRGCACVV
                     IAHRLSTVRDSDEIVVLEHGTVVERGRHAELVAHGGAYAALVGER"
ORIGIN
        1 tggccgtcgt cgacgaccgg gacccggcgc accgcgtgcg cgcgcatcag ctcgacggcg
       61 tggcccagct cctcgtccgg ccgtacggtc accatgtcgt cgctgcacgc ccccgccacg
      121 gtggtctgct ccgggtcacc gccctcggcg agcgaccgga ccaccaggtc acggtcggtg
      181 accaggccgc gcagccggtc gccctccgtg accaggacgg cgccgaggtc acggtcccgc
      241 atgaggcggg ccacctccgt gacggaggtc agcggctcga cggtcaccgg gtcgccggtc
      301 atgatgtcgc ggacgtactg ggtcatgggg tactcctcgg ttctcccgga tcgctcagtc
      361 gtggtgcgac cgcgcgggta cccggcgtcg cgccgcccgc acctcggcgg ccgcggtgac
      421 ggccggagcg gcgcgggaca tgttcaggcg ccgcccaccg ggatctcgct ccacacctgc
      481 ttgcccccgc tgaccggcag cgtcccccag gtcgccgaca tcgcctcgac caggaggatg
      541 ccgcgtccgc cggtggcctc ccagccgatg ctggtcggtt tgacgggcgt acgcggcgag
      601 gcgtcggcga ccgcgacgcg cagcctgccg ctgatcaggg tgaggtcgag ccgcaccttg
      661 ccgtcggtgt gcaccagggc gttggtgacc agctcggaga cgatcagcag gacgccgtcg
      721 acggtgtcgt ccggcacgtc ccaggagcgc agggtgcgcc gggtgaagcg gcgggcgtgc
      781 cgcacggcct cgggcagccg ccacaccgac cagctctccc gcagcgggcg cagggccatg
      841 ccgtcgtagc gcaccagcag cagggccacg tcgtcgttgc ggcgggcgtt gccgagcagg
      901 gcgtcggcga cgagcccgag gtggcccggg gcggagacgg ccagcgcgtg cgcgaaccgg
      961 tccatcccct cgtcgatgtc ggactccggc gtctccacga ggccgtccgt ggtgagggcg
     1021 atcagcgtgc cggggcgcag ccgcagcggg ctcatcggga agtcggcctg cgtcaccacg
     1081 ccgagcggcg ggccgccctc cacctcggcg atctcggtgc tgccgtcggg gtggcgcagc
     1141 accggcggca ggtgtcccgc ccgcacgcac caggcggagc cctcctccat gtcgaggtcg
     1201 acgtagacgc aggtggcgaa gaggtcggtc tccatgccgg tcagcagccg gttggcgtgg
     1261 gagaccacca cgtccggcgg atgcccctcg acggcgtagg cgcgcagggc ggtgcgcatc
     1321 tggcccatga gggtggccgc gccggcgctg tgcccctgta cgtcgccgat gacgagggcg
     1381 acgtggtggt cgggcagcgg gatcacgtcg taccagtcgc cgccgagctc gagtccggcc
     1441 gtgctgggca ggtagcgggc gacggcgacc gcgccgggca gtttcggcag cctgcgcggc
     1501 agcagctggc gctggagcat gccgaccagt tcgtgctcgg cgtcgaaggc gtgggcgcgc
     1561 atcagggcct gcccggccag gcccgcggag gcggtgagca gggcgcgttc gtcggggccg
     1621 aagtcgtgcg gagcgtccca gccgatcagg caggcaccgg ccacgcgtcc gccggcgggc
     1681 agcggcagta cggcgaggcc gccggggccg acgtcggcga gggcgggttc caggtcgccg
     1741 gtgccggcgg gccagatccg ggcgcgtccc tcgcgcagcg cggcggcgag agtgggcatg
     1801 gcccgtaccg gtgcgtccgg ccactcggtg cgccattcca ggcgccacag ctcgggccag
     1861 gactcggggt cgggcgggtc gaggacggtg acgacgagcc ggtcgttctc cagctcggcc
     1921 agcgcgatcc ggtcggccct gagcggtctg cgcagggcgg cgacgacggc ctggctgacg
     1981 tcgcggacgg tcccggcggt ggccagcgcg gcggcgagcc gctggacgcg ggcgacgtcg
     2041 gtcacgtccg ggcgcagggt ggaggcgtcg gcgacggtcc ccaccaggcg ggcgggccgg
     2101 ccgtcgccgc cgggcagcag gcgtccgctg agccgcagcc acttcggcgg gccggtgggc
     2161 tggagcaccc ggaactccag ctcgcgctcg ccgatcgtca tgtggtcgga ctcggtcacc
     2221 gacatcagcg acggcaggtc ctccggcacg gtgaggccga gcagcgtctc gaccttgccg
     2281 tcgaattccc cgggggcgag gccgaacagg cgcaggatgt cgtcgccgac ctccgcgcgg
     2341 ccggtgtcca tggccagggt gaaggcgtcc ggctggaggg caccggactc gggggtgccg
     2401 acggcctcgg ccggggcggg gcaggtcatg gccccggcga tcagtccgag gcactctcgg
     2461 tcgtcggcgt cgaatccgtc cgggcgctcg gtcaggacga gcaggcagcc gccgccgtcc
     2521 ccgcgcaccg gcaggacggc cagcgagaag ccgctggacg gcacgtgccg ggactccgcc
     2581 gatccggcga actcctccgg tccgatccac accgtctcgc ccccgcggtg ggcgtcggcg
     2641 accggggagc cgccctccgc gggatagctg tcgcggacgc cgtacagggt gcgcggcaca
     2701 ccggccgacg cgaccaggca gagcaggtcg cggtcgtcgc cgggcgtgta gagcgcggcc
     2761 agggaggcgc ccgcgaagac cagcgtctgc tcgaggatcc cgcgcagccg ctcctccggc
     2821 cccggcgctg ccgcgatcgc cttcagggca ccctcggcac gcagcgccct cggtccgcgt
     2881 tccgcagtgc cctcttcgac cacgtcgcca ttacagcgct tatgggacat gtgcgcagcc
     2941 cctacggatc ggctaccggt gatcgggggc acatcggggg ctcacggaca gacgctgcgc
     3001 gccgccggtc gggtgcgggc ggagccctgc cggtggcacg gggcggacac gcgtcgcgcg
     3061 tcgccgatac gcggtgcaga ccgccgaccc ctcccgtcgg gtgccggggc ggcggtccgc
     3121 aggacgtgcc gtcagcccgt cggccccgag ccgtcgtcgc caccgactcc cgcgtcacct
     3181 gcaccggcac cagcaccagc gtcgcccgcg tcaccgccac cggcgccctc gcccgcgtcc
     3241 ccggcaccgg caccggcacc cgcacccgca ccggcgtccc cgagggtggc gccgaccgcc
     3301 tccagggcgg tggtgaccgg ctggaagaag gtctcgccgc cgaccgtgca gtcgccgctg
     3361 ccgccggagg tcaggccgac cgcgaggccg tcccgcgtga acagggaccc gccgctgtcg
     3421 cccggctcgg cgcagacgtc ggtctgtatg aggccggtga cggtgccctc ggggtagttg
     3481 acggtggcgt ccaggccgag gacctgaccg tcggccagtc cggtcgtgct gcccatccgg
     3541 aagacctcct ggcccaccgc ggcctcggcg gcccggctga tcggcagggt ctggtcgccg
     3601 aggttcacct cgctcggggc cccggtcgcc gggtcgtcgt acttcacgag tgcgaagtcc
     3661 ccctcgccgg ggaagacggc ctggtcgacg gtggcgatcg gctgcccgcc ctgtgcgtcg
     3721 gaccactggt cggccgcgac cccgcagtga cctgccgtca ggaaggcggg cgagccgtcg
     3781 cccgcggtga cgttgaagcc gagcgagcag cgcgctccgc cgccgaagat cgcgtcgccg
     3841 cccgaggcga aggtcttgaa ggtgccggcg gacttccgca ccgtcgccat gccggaaccg
     3901 aggctctcca cggtggactc caggcggtcc caccggtcgc cggtgacggt gctgtcggcg
     3961 gtcaccagga tcctgttggt gcgcgggtcg atcgcccacg aggtgccggg gatgctcgcc
     4021 tcggacttca gggtccgggc gccgctgcgc agttccccca tgctgttgtc gacctcgcgg
     4081 acctccgcgc ccgcctgctt cgcctgcgcg acgacccggt cgtcctggcc ggggacgacg
     4141 ttgacgacga gccgctgcgc gccggagtcg tagtaggagc cggcgaaggt gtcgccgagc
     4201 aggccggcga gccgtgtggc gagatccgac gcgtccgccg acttgagggt cctgggcgcc
     4261 gcggcggcct cgtccgagga gccgccgtcc tgcgaggcgt tggcgttcgg cagcaggatc
     4321 gcggccgcgc cgagcgcgac cacaccgccc gccgccatcg cggccctgcg cttcgggatt
     4381 cgcttgtgac tcaacctact cgacctcctg ggaccggggt gggtgtccgc cggtccggca
     4441 gctgttgggg gcgcctggac ggctgttggt acgcacgggc cgggcggggt gttcagacgg
     4501 gccgcccggc cgcaccccgg cacgggccgt ttcacgccac ccctcgacac cctccgcgtt
     4561 cacccggcga cgcagtgtcc cggccaccga gcggaatgac cgcttcagcg aatctgcaca
     4621 ccgaatgccc aacccggtca ctcccgtcgg cgcatctgca caagcccgcg gcggccccta
     4681 cgcctttggg gccggagtgt cccaatcgcc tccgcgcggg caagggatcg cgcgggccga
     4741 tctcgcccac cgtgtgaaga agtcgccgcg aaggagtgcg cgctcctgca cgcatgggtg
     4801 cccgggcgtc gcaagtgcgc tggtgggagg ggtgattgat tggaagcccg gaccggccgc
     4861 gtgctttgat ccatcgcacc gcgggggccg cggagggctc tggaaacggg cgcccggtgc
     4921 ccgcggtcgc ggccgtcatc tgtccccaga gggggccgct ccccccttgt gaaaatggct
     4981 atacgaaggg aagttcccac atgaactcca ccccccaggt tgagaccgtc gagatctccg
     5041 acgccgacct cgacaacgtc tccggcggcc tgaacgtgaa cgccgtcggc accgtcaccg
     5101 gcctggtgga cggcatcgcc ccggtctccg gcctggtcaa cacggtcgtc ggcacggtcg
     5161 agggcgccac cggcctgaac accgccccgg tcacgggcct ggtcgccggt ctctgatcgc
     5221 gtccttgcgt cgctgagtcc cggagccgtc caggctccgg gacttttcgg ccgttcacga
     5281 tccccggccc ttcacggtcc ccggccgttc tcgatctccg gccgttcccc gtctgcggcc
     5341 gctctcatca agccctggat acatcagccg tgcagttccg ccaacaggcc ctctccaaac
     5401 tccagtcacc ggaagagctc gatctcccgg tgcgtttcgc ccgtccccag ggctggctgg
     5461 tgctgtccgt gaccgtcgtc gcgatggccg ccgcgtccgt gtgggcggtg ggcggctcgg
     5521 tgacctccac cgtctccgcg cccgccgtcc tcacccacgg gcagggcagt tacctgctcc
     5581 agagccccgt ctccgggcag gtcaccgcgg tcctcgcccg cccggggcag cggctgggcg
     5641 ccgacgcccc cgtgctgaag gtccgtaccg ccaagggcga gaccgtggtc cgcaccgtcg
     5701 acgccggccg ggtcagcgcg ctcgcggcga ccgtcgggca gatcatcggt accggcgcga
     5761 acgtcgcctc ggtggagaag gtcgcccacg ccgacgaccc cctctacgcc accgtgtacg
     5821 tccccgccga gaacgccgcc gccatccccg cgcacgcctc cgtcgacctg accgtgcagt
     5881 cggtgccgac gcagcagtac ggcgtgctgc acggcgaggt gaagtccgtg gaccgctcgg
     5941 cccagtcggc acagacgatc ggtgccttcc tcggggacag cgcgctcggc gagcagttca
     6001 ccgaggacgg caggccggtg gccgtgacgg tgcggctgga gacctccacg tccacgcaga
     6061 gcggctacga gtggtcctcg gccgacggac cgccgttcga actgacctcc atgaccctgg
     6121 cctcgggctc gatccggctg gccgaccagc gtcccgtcga ttggctgctg ccgtgagcac
     6181 cgcacaggag acccggggca ggcgccgcgc cgccccgccg aggcgcagcg tgccgaagag
     6241 ccgcgcgaag accgtccgca cgcccacggt gctccagatg gaggccgtgg agtgcggtgc
     6301 cgcctccctc gccatggtgc tggggcacta cggccgccac gtcccgctgg aggagctgcg
     6361 gatcgcctgc ggcgtctctc gcgacggctc ccgggcgagc aacctgctga aggccgcgcg
     6421 gagttacggg ttcaccgcca agggcatgca gatggacctg gccgcgctcg ccgaggtgac
     6481 ggcaccggcc atcctcttct gggagttcaa ccactacgtc gtctacgacg gcatgggccg
     6541 ccggttcggg cggcgcgggg tgttcatcaa cgacccgggc aagggacgca ggttcgtgtc
     6601 cctggaggac ttcgacggct ccttcaccgg tgtggtgctg accatggagc ccggtgacgg
     6661 cttcacccgc ggcggccgca agcctggtgt gctcggcgcg atgcccgccc ggctgcgcgg
     6721 gaccgcgggc acgctgcccg ccgcggtgct ggcgagcctc cttctggtgg cggtcggcgc
     6781 ggcggtgccc gcgctcagcc gcacctacat cgacatgttc ctcatcgggg ggcagacctc
     6841 gctgctcggc gtgctgttcg cgtcgatggg ggcctgtgtc ctgctcacgg tggtgctgac
     6901 ctggctccag caggccaacc tgctgcacgg ccgcatcatc tcctccaccc tctccagcgc
     6961 ccgtttcctg cggcacctgc tgcggctgcc ggtgaccttc ttctcccagc gcagccccgc
     7021 cgacctggtg cagcgcctcc agtcgaacga cgcggtcgcc gagacgctgg cccgcgacct
     7081 cgccgcggcg ggcgtggacg cgatcgtggt cgtcctgtac gccgtgctgc tgtacacgta
     7141 cgacccgcag ctcaccttcg tcggcgtcgg ggtggcgctg ctcaacatcc tcgcgatgcg
     7201 ggtcgtcatc cggctgcgcg cgacccgtac ggcgaagctg cgggcggaca ccgcgcggct
     7261 gaccaacacc gcgtacaccg gcctccagtt gatcgagacg atgaaggcga ccggtggcga
     7321 ggacggctac ttccgcaagt gggccggcca gcacgccacc acgctggagg agcagcagcg
     7381 gctcggggtg cccagtgcct ggctcggtgt ggtcgcgccg acgctcgcga cgctgaacag
     7441 cgggctgatc ctttggatcg gcggcatgcg cgcggtcgag gggcacatct cggtcgggct
     7501 gctggtcgcc ttccaggcgc tggtggtccg cttcaccgcc ccgctgaccc ggctgaacgg
     7561 tgtcgcgggc cgcatccagg acttcgcggc cgacgtggcc cggctgaagg acgtggagaa
     7621 cttccgggcg gaccccctct acgaccgtcc cggcggcgac tccacgcgcc ggctgcacgg
     7681 tcacgtcgag ttgcagaacg tctccttcgg ctacaacccg ctcgacaagc cgttgctgtc
     7741 cggtttcgac ctgaccgtcg ggccggggca gcaggtggcg ctggtgggcg gttcgggcag
     7801 cggcaagtcg acggtgtcgc ggctgatctc gggcctgtac gcgccctggg acggcgtgat
     7861 ccgcgtcgac gggcagcggc tcgacgacat cccgcgcggg gcgctggcct cctcggtctc
     7921 cttcgtcgac caggacgtgt tcctgttcga ggggtcggtg cgcgacaacg tggcgctgtg
     7981 ggacccgtcg atcccggacg acgccgtggt ggacgcgctg aaggacgccg cgctctacga
     8041 cgtggtgatg cgcaggccgg gcggcatcca cagcccggtc gagcaggacg gccgcaactt
     8101 ctccggcggg cagcgccagc gcctggagat cgcgcgggcg ctggtgcgcc ggccgagcat
     8161 cctggtgctt gacgaggtga ccagcgcgct ggacgcggag accgagctgg tggtcatgga
     8221 caacctgcgc cggcgcggct gcgcctgcgt ggtgatcgcg caccggctca gcaccgtgcg
     8281 ggacagcgac gagatcgtcg tcctggagca cggcacggtc gtggagcgcg ggcggcacgc
     8341 ggagctggtg gcacacggcg gcgcgtacgc ggcgctggtc ggggagcgat gagatgacga
     8401 ccgtgcggga aggacagggc gacctcgtcc tcggggcgct cggcgcactg ggcacccgtg
     8461 tcgactgcgc cgggttcaac cggctcgacc tggaggggcc gcaggtgctg tggctcgtgg
     8521 tgtccggcgc ggtggacctg ttcgcggtgg acgcggcgga gcagggccac tggcaccacc
     8581 tggggcgcct ggaggcgggc tcggtgctgc tcgggccggt caccgggccg cagcacacgc
     8641 tggtggcgcg cccgctgcgg gactgcgtcg tgcaccgcat cgggctgcgc gagctgtacc
     8701 agccggcgca cacccagacg tggtcgtacg acgcgtacgg caacccgcag tacgtgccgc
     8761 cgacgacgag cccgctggag tacgccctcg ccctcggcgt gggccggggc ctgaccgtcc
     8821 tcttccaggc gccgatggcc gcggagcggg ccgacgcgcc cgccgacgac gacgtgttct
     8881 ggatgcaggt gccgcccggc agcgtgcagt acggggcggt gtacggcgag gaggcggccg
     8941 ccgacctgct gatggacccg gcgctgtggc agtccatggt cgaccagcag taccggctgc
     9001 tcaccaccct ggaccgctgg atcgagcagc tggagcgcac ccacgagacg cgtaccgcgg
     9061 ccggtatcaa ggccggtgag gcggtacgcg cgcaggccga ccggacgctg ctggcctcca
     9121 tcggcaagcg gtcggcgcag cgcacgacgg ccgcggacgc cgacgccacc cacgcggcct
     9181 gcgcgctggt cgcccgcgcc gccgggatcc cgctggccga gccggcccgc agcggcacgg
     9241 agagcgaccg gctcgacccc gtggagcgca tcgcgctcgc ctcacgcgtc cgcaccaggt
     9301 ccgtacggct ggaggaccgc tggtggcgcg acgacgtcgg accgctggtc gggcaccgca
     9361 ccctgtcggg ggcgccggtg gcgctgctgt ggcggcgctg cggttatgtc gccgtacacc
     9421 cggcgaccgg acgtgagacg ccggtggaga aggcgaacgc cggggagttc gagccgcgcg
     9481 cggtgatgtt ctaccgtccg ctgccggagc gccggctcag tccgctgcgg ctgctgcggt
     9541 tctgcctgac gggcacgcgc cgggacctga ccgggctgct gctcgccggt ctggtgacgg
     9601 tgggtctcgg cgcgctggtg ccggtcgcga cgggcaaggt gctcggcgag ttcgtgccga
     9661 aggcgcagac cgggctgatc gtgcaggtgt gtctcgcggt gatgctgagc agcgtcgtcg
     9721 cggcggcctt catgctgttg cagaacctga ccatcctgcg cctggagggc cggatcgagg
     9781 cgacgctcca gcccgcggtg tgggaccggc tgctgcggct gccgaccagg ttcttcaccg
     9841 ggcgttccac cggcgagctg gcgagcgcgg ccatgggcat cagcgcgatc cgccgactcc
     9901 tcgcgggggt cggtccgacg gtggcccagt cggtgacggt cggggcggtg aacctggtgc
     9961 tgctgctgtg gttcagcgtg ccgatggcgc tcgcggcgat cggcatgctg gtggtcgtcg
    10021 ccggggtgtt cctggggctc gggctgtggc aggtgcgctg gcagcggcgg ctggtcaagc
    10081 tcaccaacaa actgaacaac caggcgttcc agaccctgcg cgggctgccc aagctgcggg
    10141 tggcggcggc cgagaactac gcctacgcgg cctgggcgga gcagttcgcg cacagccggg
    10201 aactccagca gcgggc
//
