Select genomic region:
Overview
2.1
2.2
4.1
7.1
8.1
10.1
13.1
15.1
17.1
18.1
18.2
19.1
23.1
27.1
27.2
27.3
28.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAAHBR010000011.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS,transAT-PKS | 1 | 46,710 |
Region 2.2 | NRPS | 125,241 | 179,881 | High | surfactin | NRPS:Type I

NZ_JAAHBR010000013.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | cyclic-lactone-autoinducer,lanthipeptide-class-ii | 2,747 | 32,005 | High | amyloliquecidin GF610 | ribosomal:RiPP

NZ_JAAHBR010000001.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | other | 118,418 | 159,836 | High | bacilysin | other:other

NZ_JAAHBR010000018.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | NRPS-like | 1 | 22,541 | Low | locillomycin/locillomycin B/locillomycin C | NRPS:Type I+PKS

NZ_JAAHBR010000020.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 10.1 | NRPS | 1 | 10,887 |  |

NZ_JAAHBR010000023.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 13.1 | T3PKS | 5,421 | 46,521 |

NZ_JAAHBR010000026.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | NRPS | 1 | 6,775 |

NZ_JAAHBR010000002.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 17.1 | transAT-PKS | 21,789 | 110,007 | High | macrolactin H | PKS

NZ_JAAHBR010000030.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 18.1 | terpene-precursor | 494,735 | 515,625 |
Region 18.2 | transAT-PKS | 537,717 | 643,951 | High | difficidin | PKS

NZ_JAAHBR010000003.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 19.1 | PKS-like | 65,377 | 106,621 |  |

NZ_JAAHBR010000005.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 23.1 | terpene-precursor,NRP-metallophore,NRPS,RiPP-like | 48,525 | 113,921 | High | bacillibactin | NRPS:Type I

NZ_JAAHBR010000054.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 27.1 | transAT-PKS,NRPS,T3PKS | 1 | 93,325 | High | bacillaene | NRPS:Type I+PKS:Type I
Region 27.2 | NRPS,RiPP-like,transAT-PKS,betalactone | 163,564 | 300,872 | High | fengycin | NRPS:Type I
Region 27.3 | terpene | 324,153 | 346,036 |

NZ_JAAHBR010000009.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 28.1 | terpene | 67,291 | 88,031 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS,transAT-PKS | 1 | 46,710 |
Region 2.2 | NRPS | 125,241 | 179,881 | High | surfactin | NRPS:Type I
Region 4.1 | cyclic-lactone-autoinducer,lanthipeptide-class-ii | 2,747 | 32,005 | High | amyloliquecidin GF610 | ribosomal:RiPP
Region 7.1 | other | 118,418 | 159,836 | High | bacilysin | other:other
Region 8.1 | NRPS-like | 1 | 22,541 | Low | locillomycin/locillomycin B/locillomycin C | NRPS:Type I+PKS
Region 10.1 | NRPS | 1 | 10,887 |  |
Region 13.1 | T3PKS | 5,421 | 46,521 |
Region 15.1 | NRPS | 1 | 6,775 |
Region 17.1 | transAT-PKS | 21,789 | 110,007 | High | macrolactin H | PKS
Region 18.1 | terpene-precursor | 494,735 | 515,625 |
Region 18.2 | transAT-PKS | 537,717 | 643,951 | High | difficidin | PKS
Region 19.1 | PKS-like | 65,377 | 106,621 |  |
Region 23.1 | terpene-precursor,NRP-metallophore,NRPS,RiPP-like | 48,525 | 113,921 | High | bacillibactin | NRPS:Type I
Region 27.1 | transAT-PKS,NRPS,T3PKS | 1 | 93,325 | High | bacillaene | NRPS:Type I+PKS:Type I
Region 27.2 | NRPS,RiPP-like,transAT-PKS,betalactone | 163,564 | 300,872 | High | fengycin | NRPS:Type I
Region 27.3 | terpene | 324,153 | 346,036 |
Region 28.1 | terpene | 67,291 | 88,031 |

No secondary metabolite regions were found in these records:
  NZ_JAAHBR010000010.1 (Bacillus velezensis)
  NZ_JAAHBR010000012.1 (Bacillus velezensis)
  NZ_JAAHBR010000014.1 (Bacillus velezensis)
  NZ_JAAHBR010000017.1 (Bacillus velezensis)
  NZ_JAAHBR010000019.1 (Bacillus velezensis)
  NZ_JAAHBR010000021.1 (Bacillus velezensis)
  NZ_JAAHBR010000022.1 (Bacillus velezensis)
  NZ_JAAHBR010000025.1 (Bacillus velezensis)
  NZ_JAAHBR010000027.1 (Bacillus velezensis)
  NZ_JAAHBR010000004.1 (Bacillus velezensis)
  NZ_JAAHBR010000039.1 (Bacillus velezensis)
  NZ_JAAHBR010000046.1 (Bacillus velezensis)
  NZ_JAAHBR010000006.1 (Bacillus velezensis)
  NZ_JAAHBR010000007.1 (Bacillus velezensis)
  NZ_JAAHBR010000008.1 (Bacillus velezensis)

Compact view
NZ_JAAHBR010000011.1 - Region 1 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 46,710 nt. (total: 46,710 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
G3T15_RS09065: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

G3T15_RS09150: dehydrogenase

smcogs
  SMCOG1181: dehydrogenase

Transferases: acylase methyltransferase
G3T15_RS09050: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

G3T15_RS09075: O-methyltransferase

smcogs
  SMCOG1042: O-methyltransferase

Ligases: ligase synthase
G3T15_RS09045: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS09055: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

G3T15_RS09060: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

G3T15_RS09070: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

G3T15_RS09105: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Translocases: permease
G3T15_RS09100: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000342.4 |  |  | 0.73 | NRPS | enniatin | Fusarium equiseti
BGC0002135.2 |  |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001275.3 |  |  | 0.68 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001276.3 |  |  | 0.68 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001244.3 |  |  | 0.67 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001273.3 |  |  | 0.67 | PKS | asperlactone | Aspergillus ochraceus
BGC0001261.3 |  |  | 0.65 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  |  | 0.63 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  |  | 0.63 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001275.3 |  | 0.67 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001276.3 |  | 0.67 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001244.3 |  | 0.67 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001273.3 |  | 0.67 | PKS | asperlactone | Aspergillus ochraceus
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.65 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.19 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.42 out of 27.78
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33
Confidence: medium
Additional weak hits (5):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.71 out of 20.47
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.30 out of 32.93
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 46710:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Asn - Gly) + (ccmal) + (ccmal) + (mal - D-Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS09045: Asn - Gly
Search NORINE for peptide: strict or relaxed
AMP-binding (155..549): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEYNEYGPTEATVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1657..2050): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGITFDIFGLELQLMVGGEYNMYGPTETTIWSSV
  Nearest Stachelhaus code(s):
    Gly DILQMGMVWK (85% 8Å match)
  Stachelhaus code match:
    90% (moderate)

G3T15_RS09050: mal
PKS_AT (6..293): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 75.0%
  2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 111.1
  inactive: 50.8
  Methoxymalonyl-CoA: 39.3
  Isobutyryl-CoA: 31.6
  Methylmalonyl-CoA: 29.7
  Propionyl-CoA: 12.0
  CHC-CoA: 10.8
  fatty_acid: 10.4
  Benzoyl-CoA: 10.0
  trans-1,2-CPDA: 0.0
  Ethylmalonyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

G3T15_RS09070: Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (1200..1601): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LALAFDASVKQSDGIIGGETNVYGPTECCVDAAS
  Nearest Stachelhaus code(s):
    Glu DAKDIGVVDK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_JAAHBR010000011.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 125,241 - 179,881 nt. (total: 54,641 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase
G3T15_RS09545: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

G3T15_RS09560: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

G3T15_RS09565: flavodoxin

smcogs
  SMCOG1134: flavodoxin

G3T15_RS09570: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

G3T15_RS09585: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: PPTase aminotransferase
G3T15_RS09645: aminotransferase

smcogs
  SMCOG1019: aminotransferase

G3T15_RS09660: aminotransferase

smcogs
  SMCOG1019: aminotransferase

G3T15_RS09665: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase
G3T15_RS09640: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
G3T15_RS09580: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

G3T15_RS09630: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS09635: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.5 |  | 0.78 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.72 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000426.5 |  | 0.72 | NRPS | sevadicin | Paenibacillus larvae
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.70 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.5 |  | 0.78 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.72 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000426.5 |  | 0.72 | NRPS | sevadicin | Paenibacillus larvae
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.70 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
Additional weak hits (17):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.91 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.29 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.14 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.21 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 23.04 out of 30.12
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.79 out of 20.01
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.24 out of 29.38
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 125240 - 179881:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS09630: Glu - Leu - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (465..867): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1511..1908): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
  Nearest Stachelhaus code(s):
    Leu DAFMMGMVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2550..2939): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS09635: Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (469..867): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHVSFDAFTFDSFALFGGEINCYGPTEGTVFATA
  Nearest Stachelhaus code(s):
    Leu DAFFLGCVFK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_JAAHBR010000013.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,747 - 32,005 nt. (total: 29,259 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
G3T15_RS11035: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
G3T15_RS10970: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

G3T15_RS10985: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002663.2 |  |  | 1.04 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0000517.4 |  |  | 0.57 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000623.3 |  |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000525.5 |  |  | 0.43 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000504.5 |  |  | 0.42 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001210.5 |  |  | 0.42 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000497.3 |  |  | 0.39 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0001311.5 |  |  | 0.37 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000626.3 |  |  | 0.36 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001391.3 |  |  | 0.34 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002663.2 |  | 0.95 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0000623.3 |  | 0.66 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000517.4 |  | 0.65 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000504.5 |  | 0.61 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001210.5 |  | 0.56 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000499.3 |  | 0.55 | ribosomal | butyrivibriocin OR79 | Butyrivibrio fibrisolvens
BGC0000497.3 |  | 0.54 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002110.3 |  | 0.54 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000521.3 |  | 0.53 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for G3T15_RS10970

G3T15_RS10965
Leader:
MSIIETWKNPALRMNSQVVNPAGDLMEELSDDEMEMLAGG
Core:
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
Core with dehydrations:
Cys A W Y D I Dha Cys K L G N K G A W Cys Dhb L Dhb V E Cys Q Dha Dha Cys N

#### antiSMASH-DB 4.0 matches for G3T15_RS10965

100.0%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
85.7%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide
Lanthipeptides: IM743_RS02795_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C A W Y D+S C+L G N K G A W C T L T V E C Q++C N
1
C A W Y D V S C R L G N K G A W C T L T V E C Q N N C N
28
75.0%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C
27
C W Y+I S C+L G N K G W C T L T E C Q S C
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
with 101 more sequence matches
Only the first 10 are displayed here.
71.9%
NC_002570.2 and 3 others:
NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide
Lanthipeptides: AYT26_RS02480_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C A W Y+I S C+L G N K G A+C T L T V E C S C N
5
C A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
32
65.5%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C W++I S C L G N G +C T L T E C Q S C N
1
C D W W N I S C H L G N T G Q F C T L T K E C Q P S C N
28
62.1%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C W++I S C L G N G +C T L T E C Q +C N
1
C D W W N I S C H L G N T G R F C T L T K E C Q P N C N
28
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
3
W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
W+++S L G N K G C T L T E C Q S C N
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
57.1%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
2
A W Y-D I S C K L G N K G A W C T L T V E C Q S S C N
28
W Y ++S L G N+G++C T L T E C Q+ C N
1
G W Y S E M S A A L G N R G S Y C T L T K E C Q A C C N
28
57.1%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
2
A W Y-D I S C K L G N K G A W C T L T V E C Q S S C N
28
W Y D+S L G N+G++C T+T E C Q+ C N
1
G W Y A D L S A S L G N R G S Y C T I T K E C Q A C C N
28
57.1%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
2
A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
W D+S L G N K G C T L T E C Q C
2
G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
56.7%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
4
Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
+ +S L G N K G W C T L T E C Q S C N
6
F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
55.2%
NZ_CP036016.1:
Lanthipeptides: allorf_075467_075682_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C
27
C W+D+S C L G N G+ C T L+V E C+ +C
2
C T W W D L S C H L G N D G S T C T L S V E C R P A C
28
53.6%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
6
I S C K L G N K G A W C T L T V E C Q S S C N
28
+S K L G N G C T L T E C Q C N
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27

#### MIBiG 4.0 matches for G3T15_RS10965

82.1%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C A W Y+I S C+L G N K G A+C T L T V E C S C N
1
C A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
50.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
4
Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
+ +S L G N G W C T L T E C Q +C N
6
F S L S N A L G N N G G W C T L T K E C Q P N C N
30
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
C T L T V E C Q S S C N
28
C T L+ E C Q +C N
28
C T L S K E C Q P N C N
39
G3T15_RS10975
Leader:
MTKQEKAAIYRDVNKHSELGLESPVGEVNEEELKNLAGA
Core:
K N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
Core with dehydrations:
K N V N Q E E P L Dha Dha F I P G P G Dhb Cys L Dhb A A I Cys P Dhb Dhb G M Cys N I Y

#### antiSMASH-DB 4.0 matches for G3T15_RS10975

100.0%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13810_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptide
Lanthipeptides: BAMY6639_RS13810_lanthipeptide
1
K N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
34
K N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
1
K N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
34
82.4%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: allorf_0557723_0557881_lanthipeptide
Lanthipeptides: allorf_0557723_0557881_lanthipeptide
2
N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
34
N V Q E S S F I P G P G T C L T A A I C P T T G M C N Y
2
N V A Q N E T H S S F I P G P G T C L T A A I C P T T G M C N K Y
34
34.3%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
2
N V N Q E E-P L S S F I P G P G T C L T A A I C P T T
28
+V N E P + I G +T A++C P T T
2
D V N P E T T P A T P T I I G A T I A V T A S L C P T T
29
with 6 more sequence matches
24.3%
NZ_CM001792.1 and 1 other:
NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide
Lanthipeptides: C794_RS17975_lanthipeptide
5
Q E E P L S S F I P G P G T C--L T A A I C P T T G
29
++ L S P G+C ++ A C P T+
3
E Q N S L S P L T P S S G S C V A I S L A F C P T S A
29
23.5%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
20
L T A A I C P T T G M C N I Y
34
++A A I C P T T +I
14
I S A A I C P T T Q C A S I V
28
21.4%
NZ_BMMP01000005.1 and 3 others:
NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide
Lanthipeptides: IEY56_RS09415_lanthipeptide
10
S S F I P G P G T C L T A A I C P T T
28
++++ T T A A I C P T T
18
T A W V C A T V T L A T A A I C P T T
36
20.9%
NZ_QLLX01000002.1 and 1 other:
NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide
Lanthipeptides: K378_RS30040_lanthipeptide
18
T C L T A A I C P T T
28
T T A A I C P T T
27
T L A T A A I C P T T
37
18.6%
NZ_JAASAG010000001.1 and 1 other:
NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide
Lanthipeptides: HCC61_RS01465_lanthipeptide
21
T A A I C P T T
28
T A A I C P T T
30
T A A I C P T T
37
17.6%
NZ_BBZF01000020.1:
Lanthipeptides: LPU43_RS18755_lanthipeptide
14
P G P G T C L T A A I C P T T G M
30
P G P + + +C P + M
4
P G P A S N A S V V L C P I S V M
20

#### MIBiG 4.0 matches for G3T15_RS10975

16.2%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
20
L T A A I C P T T
28
++A A C P T T
23
V S A A F C P T T
31
11.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
24
I C P T T
28
C P T T
16
F C P T T
20
G3T15_RS10980
Leader:
MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGA
Core:
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
Core with dehydrations:
A D V Dhb P H Dhb Dhb P Dha Dha L P Cys G V F V Dhb A A F Cys P Dha Dhb K Cys Dhb Dha Dha Cys

#### antiSMASH-DB 4.0 matches for G3T15_RS10980

100.0%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
78.1%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide
Lanthipeptides: BALI_RS00915_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
A D V T P H T T P S S L P C G V T A +C P S C T S C
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
65.6%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
D V P T T P S S+ C G+ V+A F C P+T K C T S C
1
G D V D P Q T T P S S V A C G I A V S A L F C P T T K C T S Q C
32
with 123 more sequence matches
Only the first 10 are displayed here.
55.3%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
2
D V T P H T T P---S S L P C---G V F V T A A F C P S T K C T S S C
32
D V P T T P S S C G V V+A+ C P+T K C T S C
2
D V N P E T T P A T T S S W T C I T A G V T V S A S L C P T T K C T S R C
38
53.1%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
D V P T T P++ P V V+ C P+T K C T S C
1
G D V N P E T T P A T-P T I V A V S L G I C P T T K C T S K C
31
53.1%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
8
T P S S L P C G V F V T A A F C P S T K C T S S C
32
T S S C G V +A A F C P S T C T S C
5
T T S S W I C G V-A S A A F C P S T A C T S K C
28
53.1%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide
Lanthipeptides: C8268_RS00150_lanthipeptide
8
T P S S L P C G V F V T A A F C P S T K C T S S C
32
T S S C G F V T A A C P S T C T C
8
T T S S W I C G-F V T A A L C P S T A C T G D C
31
51.3%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
1
A D V T P H T T P---S S L P C---G V F V T A A F C P S T K C T S S C
32
D V P T T P S S P C V ++A C P+T K C T S C
2
G D V N P E T T P L T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
51.3%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide
Lanthipeptides: PDUR_RS29295_lanthipeptide
1
A D V T P H T T---P S S L P C---G V F V T A A F C P S T K C T S S C
32
D V P T T S S C G V V+A+ C P+T K C T S C
2
G D V N P E T T I L T T S S W T C I T A G V T V S A S L C P T T K C T S Q C
39
48.6%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
A D V T P H T T P S S---L P C G V F V T A A F C P S T K C T S S C
32
D V P T T P++ + + V T A+ C P+T K C T S C
1
G D V N P E T T P A T P T I I G A T I A V T A S L C P T T K C T S R C
35
46.9%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
D V+P T T P++ V ++ C P+T K C T S C
1
G D V S P E T T P A T P T I V V A I S V G L C P T T K C T S K C
32
46.9%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
7
T T P S S L P C G V F V T A A F C P S T K C T S S C
32
T T P S S P C G+ +T C P+ C T S C
2
T T P S S W P C G I G I T T T I C P T A V C T S K C
27
46.9%
NZ_MLKL01000042.1:
Lanthipeptides: BKK45_RS27405_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
D V P T T P++ P V V+ C P+ C T S C
1
G D V N P E T T P A T-P T I V A V S V K L C P T G V C T K S C
31

#### MIBiG 4.0 matches for G3T15_RS10980

35.1%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
16
V F V T A A F C P S T K C T S S C
32
V V+A A F C P+T K C T S C
21
V G V S A A F C P T T K C T S R C
37
28.1%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
F C P S T K C T S S C
32
F C P+T K C T S C
16
F C P T T K C T S K C
26
11.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
8
T P S S L P C
14
T S S L P C
42
T L S S L P C
48

#### Lanthipeptide(s) for G3T15_RS10985

G3T15_RS10965
Leader:
MSIIETWKNPALRMNSQVVNPAGDLMEELSDDEMEMLAGG
Core:
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
Core with dehydrations:
Cys A W Y D I Dha Cys K L G N K G A W Cys Dhb L Dhb V E Cys Q Dha Dha Cys N

#### antiSMASH-DB 4.0 matches for G3T15_RS10965

100.0%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
85.7%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide
Lanthipeptides: IM743_RS02795_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C A W Y D+S C+L G N K G A W C T L T V E C Q++C N
1
C A W Y D V S C R L G N K G A W C T L T V E C Q N N C N
28
75.0%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C
27
C W Y+I S C+L G N K G W C T L T E C Q S C
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
with 101 more sequence matches
Only the first 10 are displayed here.
71.9%
NC_002570.2 and 3 others:
NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide
Lanthipeptides: AYT26_RS02480_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C A W Y+I S C+L G N K G A+C T L T V E C S C N
5
C A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
32
65.5%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C W++I S C L G N G +C T L T E C Q S C N
1
C D W W N I S C H L G N T G Q F C T L T K E C Q P S C N
28
62.1%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C W++I S C L G N G +C T L T E C Q +C N
1
C D W W N I S C H L G N T G R F C T L T K E C Q P N C N
28
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
3
W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
W+++S L G N K G C T L T E C Q S C N
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
57.1%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
2
A W Y-D I S C K L G N K G A W C T L T V E C Q S S C N
28
W Y ++S L G N+G++C T L T E C Q+ C N
1
G W Y S E M S A A L G N R G S Y C T L T K E C Q A C C N
28
57.1%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
2
A W Y-D I S C K L G N K G A W C T L T V E C Q S S C N
28
W Y D+S L G N+G++C T+T E C Q+ C N
1
G W Y A D L S A S L G N R G S Y C T I T K E C Q A C C N
28
57.1%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
2
A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
W D+S L G N K G C T L T E C Q C
2
G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
56.7%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
4
Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
+ +S L G N K G W C T L T E C Q S C N
6
F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
55.2%
NZ_CP036016.1:
Lanthipeptides: allorf_075467_075682_lanthipeptide
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C
27
C W+D+S C L G N G+ C T L+V E C+ +C
2
C T W W D L S C H L G N D G S T C T L S V E C R P A C
28
53.6%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
6
I S C K L G N K G A W C T L T V E C Q S S C N
28
+S K L G N G C T L T E C Q C N
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27

#### MIBiG 4.0 matches for G3T15_RS10965

82.1%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
C A W Y+I S C+L G N K G A+C T L T V E C S C N
1
C A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
50.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
4
Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
+ +S L G N G W C T L T E C Q +C N
6
F S L S N A L G N N G G W C T L T K E C Q P N C N
30
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
C T L T V E C Q S S C N
28
C T L+ E C Q +C N
28
C T L S K E C Q P N C N
39
G3T15_RS10975
Leader:
MTKQEKAAIYRDVNKHSELGLESPVGEVNEEELKNLAGA
Core:
K N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
Core with dehydrations:
K N V N Q E E P L Dha Dha F I P G P G Dhb Cys L Dhb A A I Cys P Dhb Dhb G M Cys N I Y

#### antiSMASH-DB 4.0 matches for G3T15_RS10975

100.0%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13810_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptide
Lanthipeptides: BAMY6639_RS13810_lanthipeptide
1
K N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
34
K N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
1
K N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
34
82.4%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: allorf_0557723_0557881_lanthipeptide
Lanthipeptides: allorf_0557723_0557881_lanthipeptide
2
N V N Q E E P L S S F I P G P G T C L T A A I C P T T G M C N I Y
34
N V Q E S S F I P G P G T C L T A A I C P T T G M C N Y
2
N V A Q N E T H S S F I P G P G T C L T A A I C P T T G M C N K Y
34
34.3%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
2
N V N Q E E-P L S S F I P G P G T C L T A A I C P T T
28
+V N E P + I G +T A++C P T T
2
D V N P E T T P A T P T I I G A T I A V T A S L C P T T
29
with 6 more sequence matches
24.3%
NZ_CM001792.1 and 1 other:
NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide
Lanthipeptides: C794_RS17975_lanthipeptide
5
Q E E P L S S F I P G P G T C--L T A A I C P T T G
29
++ L S P G+C ++ A C P T+
3
E Q N S L S P L T P S S G S C V A I S L A F C P T S A
29
23.5%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
20
L T A A I C P T T G M C N I Y
34
++A A I C P T T +I
14
I S A A I C P T T Q C A S I V
28
21.4%
NZ_BMMP01000005.1 and 3 others:
NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide
Lanthipeptides: IEY56_RS09415_lanthipeptide
10
S S F I P G P G T C L T A A I C P T T
28
++++ T T A A I C P T T
18
T A W V C A T V T L A T A A I C P T T
36
20.9%
NZ_QLLX01000002.1 and 1 other:
NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide
Lanthipeptides: K378_RS30040_lanthipeptide
18
T C L T A A I C P T T
28
T T A A I C P T T
27
T L A T A A I C P T T
37
18.6%
NZ_JAASAG010000001.1 and 1 other:
NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide
Lanthipeptides: HCC61_RS01465_lanthipeptide
21
T A A I C P T T
28
T A A I C P T T
30
T A A I C P T T
37
17.6%
NZ_BBZF01000020.1:
Lanthipeptides: LPU43_RS18755_lanthipeptide
14
P G P G T C L T A A I C P T T G M
30
P G P + + +C P + M
4
P G P A S N A S V V L C P I S V M
20

#### MIBiG 4.0 matches for G3T15_RS10975

16.2%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
20
L T A A I C P T T
28
++A A C P T T
23
V S A A F C P T T
31
11.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
24
I C P T T
28
C P T T
16
F C P T T
20
G3T15_RS10980
Leader:
MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGA
Core:
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
Core with dehydrations:
A D V Dhb P H Dhb Dhb P Dha Dha L P Cys G V F V Dhb A A F Cys P Dha Dhb K Cys Dhb Dha Dha Cys

#### antiSMASH-DB 4.0 matches for G3T15_RS10980

100.0%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
78.1%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide
Lanthipeptides: BALI_RS00915_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
A D V T P H T T P S S L P C G V T A +C P S C T S C
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
65.6%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
D V P T T P S S+ C G+ V+A F C P+T K C T S C
1
G D V D P Q T T P S S V A C G I A V S A L F C P T T K C T S Q C
32
with 123 more sequence matches
Only the first 10 are displayed here.
55.3%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
2
D V T P H T T P---S S L P C---G V F V T A A F C P S T K C T S S C
32
D V P T T P S S C G V V+A+ C P+T K C T S C
2
D V N P E T T P A T T S S W T C I T A G V T V S A S L C P T T K C T S R C
38
53.1%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
D V P T T P++ P V V+ C P+T K C T S C
1
G D V N P E T T P A T-P T I V A V S L G I C P T T K C T S K C
31
53.1%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
8
T P S S L P C G V F V T A A F C P S T K C T S S C
32
T S S C G V +A A F C P S T C T S C
5
T T S S W I C G V-A S A A F C P S T A C T S K C
28
53.1%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide
Lanthipeptides: C8268_RS00150_lanthipeptide
8
T P S S L P C G V F V T A A F C P S T K C T S S C
32
T S S C G F V T A A C P S T C T C
8
T T S S W I C G-F V T A A L C P S T A C T G D C
31
51.3%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
1
A D V T P H T T P---S S L P C---G V F V T A A F C P S T K C T S S C
32
D V P T T P S S P C V ++A C P+T K C T S C
2
G D V N P E T T P L T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
51.3%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide
Lanthipeptides: PDUR_RS29295_lanthipeptide
1
A D V T P H T T---P S S L P C---G V F V T A A F C P S T K C T S S C
32
D V P T T S S C G V V+A+ C P+T K C T S C
2
G D V N P E T T I L T T S S W T C I T A G V T V S A S L C P T T K C T S Q C
39
48.6%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
A D V T P H T T P S S---L P C G V F V T A A F C P S T K C T S S C
32
D V P T T P++ + + V T A+ C P+T K C T S C
1
G D V N P E T T P A T P T I I G A T I A V T A S L C P T T K C T S R C
35
46.9%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
D V+P T T P++ V ++ C P+T K C T S C
1
G D V S P E T T P A T P T I V V A I S V G L C P T T K C T S K C
32
46.9%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
7
T T P S S L P C G V F V T A A F C P S T K C T S S C
32
T T P S S P C G+ +T C P+ C T S C
2
T T P S S W P C G I G I T T T I C P T A V C T S K C
27
46.9%
NZ_MLKL01000042.1:
Lanthipeptides: BKK45_RS27405_lanthipeptide
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
D V P T T P++ P V V+ C P+ C T S C
1
G D V N P E T T P A T-P T I V A V S V K L C P T G V C T K S C
31

#### MIBiG 4.0 matches for G3T15_RS10980

35.1%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
16
V F V T A A F C P S T K C T S S C
32
V V+A A F C P+T K C T S C
21
V G V S A A F C P T T K C T S R C
37
28.1%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
F C P S T K C T S S C
32
F C P+T K C T S C
16
F C P T T K C T S K C
26
11.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
8
T P S S L P C
14
T S S L P C
42
T L S S L P C
48

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 21.55
Confidence: medium
Additional weak hits (1):
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

G3T15_RS10965 - Class II
  Cleavage pHMM score: 2.80
  RODEO score: 0
  Monoisotopic mass: 2992.3 Da
  Molecular weight: 2994.4 Da
  Number of bridges: 5
G3T15_RS10975 - Class II
  Cleavage pHMM score: 3.70
  RODEO score: 0
  Monoisotopic mass: 3460.7 Da
  Molecular weight: 3463.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3481.0 Da N = 1
    3499.0 Da N = 2
    3517.0 Da N = 3
G3T15_RS10980 - Class II
  Cleavage pHMM score: 3.80
  RODEO score: 0
  Monoisotopic mass: 3016.4 Da
  Molecular weight: 3018.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3036.4 Da N = 1
    3054.5 Da N = 2
    3072.5 Da N = 3
    3090.5 Da N = 4
    3108.5 Da N = 5
    3126.5 Da N = 6
    3144.6 Da N = 7
G3T15_RS10965 - Class II
  Cleavage pHMM score: 2.80
  RODEO score: 0
  Monoisotopic mass: 2992.3 Da
  Molecular weight: 2994.4 Da
  Number of bridges: 5
G3T15_RS10975 - Class II
  Cleavage pHMM score: 3.70
  RODEO score: 0
  Monoisotopic mass: 3460.7 Da
  Molecular weight: 3463.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3481.0 Da N = 1
    3499.0 Da N = 2
    3517.0 Da N = 3
G3T15_RS10980 - Class II
  Cleavage pHMM score: 3.80
  RODEO score: 0
  Monoisotopic mass: 3016.4 Da
  Molecular weight: 3018.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3036.4 Da N = 1
    3054.5 Da N = 2
    3072.5 Da N = 3
    3090.5 Da N = 4
    3108.5 Da N = 5
    3126.5 Da N = 6
    3144.6 Da N = 7

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation

NZ_JAAHBR010000001.1 - Region 1 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 118,418 - 159,836 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
G3T15_RS00755: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS00775: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS00810: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase
G3T15_RS00760: aminotransferase

smcogs
  SMCOG1019: aminotransferase

G3T15_RS00840: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

G3T15_RS00865: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase lyase
G3T15_RS00770: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

G3T15_RS00830: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

G3T15_RS00835: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease
G3T15_RS00665: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

G3T15_RS00800: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.4 |  | 0.96 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000888.5 |  | 0.95 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000773.3 |  | 0.55 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000790.3 |  | 0.54 | saccharide | O-antigen | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000791.3 |  | 0.53 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000795.3 |  | 0.52 | saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.4 |  | 0.96 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000888.5 |  | 0.95 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000773.3 |  | 0.55 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000790.3 |  | 0.54 | saccharide | O-antigen | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000791.3 |  | 0.53 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000795.3 |  | 0.52 | saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.63 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.12 out of 23.79
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.47 out of 28.19
Confidence: medium
Additional weak hits (7):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.32 out of 26.06
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.62 out of 32.93
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAAHBR010000018.1 - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 22,541 nt. (total: 22,541 nt) Show pHMM detection rules used
Region on contig edge.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
G3T15_RS13000: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Hydrolases: esterase
G3T15_RS12940: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase
G3T15_RS12935: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease
G3T15_RS12980: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.64 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.64 | NRPS | AM-toxin | Alternaria alternata
BGC0001758.4 |  | 0.63 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001240.4 |  | 0.62 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001825.4 |  | 0.61 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.64 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.64 | NRPS | AM-toxin | Alternaria alternata
BGC0001758.4 |  | 0.63 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001240.4 |  | 0.62 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001825.4 |  | 0.61 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.63 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06
Confidence: medium
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.01 out of 30.22
Confidence: medium
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 22541:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS12935: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (248..645): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LETAFDASTFEGWLLVGGDINGYGPTEGTTFTCC
  Nearest Stachelhaus code(s):
    Val DAFWLGGTFK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ClgR | Caseinolytic protease gene regulator
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_JAAHBR010000020.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 10,887 nt. (total: 10,887 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
G3T15_RS13080: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

G3T15_RS19855: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

G3T15_RS20000: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.71 | NRPS | AM-toxin | Alternaria alternata
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.71 | NRPS | AM-toxin | Alternaria alternata
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 10887:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val) + (Asp)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS20000: Asp - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (437..839): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1482..1865): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS19855: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (470..864): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_JAAHBR010000023.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,421 - 46,521 nt. (total: 41,101 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase methyltransferase
G3T15_RS13620: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

G3T15_RS13630: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: hydrolase
G3T15_RS13600: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Ligases: synthase
G3T15_RS13625: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002332.2 |  | 0.44 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0002254.3 |  | 0.33 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0001964.2 |  | 0.33 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001663.3 |  | 0.32 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110
BGC0001928.2 |  | 0.32 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002332.2 |  | 0.44 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0002254.3 |  | 0.33 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0001964.2 |  | 0.33 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001663.3 |  | 0.32 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110
BGC0001928.2 |  | 0.32 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.26 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.39 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.67 out of 21.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.26 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.96 out of 24.78
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.10 out of 32.93
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.15 out of 18.46
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19
Confidence: medium
Additional weak hits (12):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.18 out of 25.75
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.28 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.96 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.56 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.01 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.58 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.23 out of 29.38
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.07 out of 30.22
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.96 out of 29.65
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.45 out of 29.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.42 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAAHBR010000026.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 6,775 nt. (total: 6,775 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
G3T15_RS13925: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS20005: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000396.5 |  | 0.71 | NRPS | nodularin | Nostoc sp. 73.1
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001050.5 |  | 0.68 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000426.5 |  | 0.68 | NRPS | sevadicin | Paenibacillus larvae
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000396.5 |  | 0.71 | NRPS | nodularin | Nostoc sp. 73.1
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001050.5 |  | 0.68 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000426.5 |  | 0.68 | NRPS | sevadicin | Paenibacillus larvae
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 6775:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Phe - Asp)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS20005: Asp
Search NORINE for peptide: strict or relaxed
AMP-binding (264..665): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWVSFDLCYTSPKMILGGEINHYGPTESTVGCIA
  Nearest Stachelhaus code(s):
    Asp DLTKIGHVGK (65% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS13925: Phe
Search NORINE for peptide: strict or relaxed
AMP-binding (155..546): Phe
nrpys: Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LVFAFDASVWEMTLITAGSINAYGPTETTICSTM
  Nearest Stachelhaus code(s):
    Phe DAWTIAAICK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_JAAHBR010000002.1 - Region 1 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 21,789 - 110,007 nt. (total: 88,219 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
G3T15_RS01685: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

G3T15_RS01715: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS01725: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS01730: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS01740: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase kinase
G3T15_RS01745: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

G3T15_RS01845: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Hydrolases: deacetylase deformylase hydrolase phosphatase
G3T15_RS01645: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

G3T15_RS01675: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

G3T15_RS01705: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

G3T15_RS01710: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

G3T15_RS01760: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

G3T15_RS01765: hydrolase

smcogs
  SMCOG1179: hydrolase

Ligases: synthase
G3T15_RS01695: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

G3T15_RS01735: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001383.3 |  | 0.91 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0000181.5 |  | 0.90 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.63 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001383.3 |  | 0.91 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0000181.5 |  | 0.90 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.63 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
Additional weak hits (7):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.20 out of 31.73
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 21788 - 110007:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:
  G3T15_RS01740 + G3T15_RS01735 + G3T15_RS01730 + G3T15_RS01725 + G3T15_RS01720 + G3T15_RS01715 + G3T15_RS01710

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS01745: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 91.9
  inactive: 31.2
  Methoxymalonyl-CoA: 26.1
  Methylmalonyl-CoA: 19.6
  Propionyl-CoA: 16.9
  fatty_acid: 13.9
  trans-1,2-CPDA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis

NZ_JAAHBR010000030.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 494,735 - 515,625 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
G3T15_RS16605: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
G3T15_RS16635: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

G3T15_RS16640: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
G3T15_RS16635: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25
Confidence: medium
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
SypG | Regulator of biofilm formation and host colonization

NZ_JAAHBR010000030.1 - Region 2 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 537,717 - 643,951 nt. (total: 106,235 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
G3T15_RS16860: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

G3T15_RS16885: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

G3T15_RS16925: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS16930: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS16950: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS16955: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS16965: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

G3T15_RS16970: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

G3T15_RS16995: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS17075: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acylase transferase
G3T15_RS16835: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

G3T15_RS16905: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase hydrolase
G3T15_RS16840: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

G3T15_RS16990: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase
G3T15_RS16980: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
G3T15_RS16920: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS16940: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

G3T15_RS16960: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

G3T15_RS16975: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.91 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001164.3 |  | 0.64 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002056.3 |  | 0.58 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001795.3 |  | 0.54 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000067.5 |  | 0.54 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0001012.3 |  | 0.53 | NRPS, PKS | meridamycin | Streptomyces violaceusniger
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001383.3 |  | 0.52 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.91 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001164.3 |  | 0.64 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002056.3 |  | 0.58 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001795.3 |  | 0.54 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000067.5 |  | 0.54 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0001012.3 |  | 0.53 | NRPS, PKS | meridamycin | Streptomyces violaceusniger
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001383.3 |  | 0.52 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.92 out of 25.88
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.93 out of 27.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31
Confidence: medium
Additional weak hits (11):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.31 out of 28.14
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.69 out of 27.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 537716 - 643951:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (Me-ccmal - ccmal - mal) + (ohmal - mal) + (mal) + (ccmal - ccmal) + (ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:
  G3T15_RS16930 + G3T15_RS16935 + G3T15_RS16940 + G3T15_RS16945 + G3T15_RS16950 + G3T15_RS16955 + G3T15_RS16960 + G3T15_RS16965

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS16905: mal
PKS_AT (4..281): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 87.7
  inactive: 30.9
  Methoxymalonyl-CoA: 29.3
  Methylmalonyl-CoA: 21.7
  Propionyl-CoA: 16.5
  2-Methylbutyryl-CoA: 15.4
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

G3T15_RS16920: X
AMP-binding (15..363): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
  Nearest Stachelhaus code(s):
    2,3-dohHda IGNPTGTIMK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
LexA variant 2 | Repressor of DNA damage response
MexT | Global virulence regulator
PsrA | Oleic acid responsive regulator
ToxT | Regulator of MSHA biosynthesis

NZ_JAAHBR010000003.1 - Region 1 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 65,377 - 106,621 nt. (total: 41,245 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
G3T15_RS03560: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase
G3T15_RS03590: acyltransferase

smcogs
  SMCOG1141: acyltransferase

G3T15_RS03605: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase
G3T15_RS03650: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: synthase
G3T15_RS03610: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease
G3T15_RS03565: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.50 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.48 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.44 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001292.5 |  | 0.42 | other (other) | A33853 | Streptomyces sp. NRRL 12068
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.50 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.48 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.44 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001292.5 |  | 0.42 | other (other) | A33853 | Streptomyces sp. NRRL 12068
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.70 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.33 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.85 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19
Confidence: medium
Additional weak hits (12):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.53 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.42 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_JAAHBR010000005.1 - Region 1 - NRP-metallophore,NRPS,RiPP-like,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 48,525 - 113,921 nt. (total: 65,397 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
G3T15_RS05005: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS05080: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS05130: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

G3T15_RS05135: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

G3T15_RS05180: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase
G3T15_RS05175: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: esterase hydrolase
G3T15_RS04925: thioesterase superfamily protein

smcogs
  SMCOG1144: thioesterase superfamily protein

G3T15_RS04970: isochorismatase

smcogs
  SMCOG1027: isochorismatase

G3T15_RS05065: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase
G3T15_RS05075: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthetase
G3T15_RS04945: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

G3T15_RS05060: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

G3T15_RS05070: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | NRP-metallophore | NRPS | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0000616.4 |  |  |  |  | 2.65 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  |  |  |  | 1.63 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  |  |  | 1.05 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  |  |  | 1.04 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  |  |  | 0.87 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  |  |  | 0.86 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  |  |  | 0.75 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.98 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  | 0.94 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.80 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
G3T15_RS04945: PT_FPPS_like
Domain 1 (62 - 308): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 23.04 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.00 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
Additional weak hits (17):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.36 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.99 out of 33.14
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 48524 - 113921:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 62135 - 113871:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS05060: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (456..855): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1513..1929): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS05070: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (100% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAAHBR010000054.1 - Region 1 - NRPS,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 93,325 nt. (total: 93,325 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
G3T15_RS17975: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS17995: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: acylase
G3T15_RS17935: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

G3T15_RS17940: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

G3T15_RS17945: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease
G3T15_RS17930: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

G3T15_RS18015: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase
G3T15_RS17960: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

G3T15_RS17965: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
G3T15_RS17955: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

G3T15_RS17970: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

G3T15_RS17980: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

G3T15_RS17985: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

G3T15_RS17990: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | T3PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001089.5 |  |  |  |  | 1.69 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0001160.5 |  |  |  |  | 1.03 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0002135.2 |  |  |  |  | 1.03 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  |  |  |  | 0.97 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  |  |  |  | 0.97 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001833.4 |  |  |  |  | 0.96 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  |  |  | 0.96 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  |  |  | 0.95 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  |  |  | 0.94 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  |  | 0.91 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001089.5 |  | 0.91 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0002135.2 |  | 0.70 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.96 out of 24.78
Confidence: medium
Additional weak hits (15):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.29 out of 30.25
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.94 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.06 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.97 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.38 out of 28.14
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 93325:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS17935: mal
PKS_AT (4..285): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 100.0
  inactive: 46.8
  Methoxymalonyl-CoA: 38.9
  Methylmalonyl-CoA: 25.3
  Propionyl-CoA: 23.1
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

G3T15_RS17940: mal
PKS_AT (7..293): mal
ATSignature: (unknown)
No matches above 50%
minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 35.4
  inactive: 26.4
  Methoxymalonyl-CoA: 14.9
  Benzoyl-CoA: 14.0
  Methylmalonyl-CoA: 9.2
  Isobutyryl-CoA: 8.8
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

G3T15_RS17945: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 92.8
  inactive: 28.2
  Methoxymalonyl-CoA: 23.4
  Methylmalonyl-CoA: 11.0
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

G3T15_RS17970: fatty_acid - Gly
Search NORINE for peptide: strict or relaxed
CAL_domain (74..476): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 26.7
  NH2: 9.4
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (1145..1540): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
  Nearest Stachelhaus code(s):
    Gly DILQLGMIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS17985: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (492..896): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
  Nearest Stachelhaus code(s):
    Ala DVSNMAIIYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_JAAHBR010000054.1 - Region 2 - NRPS,RiPP-like,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 163,564 - 300,872 nt. (total: 137,309 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
G3T15_RS18615: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

G3T15_RS18635: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

G3T15_RS18710: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

G3T15_RS18815: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase
G3T15_RS18610: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

G3T15_RS18655: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

G3T15_RS18670: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

G3T15_RS18680: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

G3T15_RS18700: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase
G3T15_RS18790: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

Lyases: hydratase
G3T15_RS18685: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
G3T15_RS18595: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

G3T15_RS18600: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS18605: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

G3T15_RS18650: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

G3T15_RS18690: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

G3T15_RS18705: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS18725: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

G3T15_RS18735: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS18740: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

G3T15_RS18745: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS18750: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS19900: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

G3T15_RS19905: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | RiPP-like | transAT-PKS | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001098.5 |  |  |  |  |  | 1.61 | NRPS, PKS | iturin | Bacillus subtilis
BGC0002135.2 |  |  |  |  |  | 1.60 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  |  |  |  |  | 1.59 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  |  |  | 1.52 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  |  |  |  | 1.50 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001090.5 |  |  |  |  |  | 1.50 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001825.4 |  |  |  |  |  | 1.50 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  |  |  |  |  | 1.50 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  |  |  | 1.48 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  |  |  |  |  | 1.47 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001095.5 |  | 0.90 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0001098.5 |  | 0.89 | NRPS, PKS | iturin | Bacillus subtilis
BGC0001090.5 |  | 0.88 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0000402.4 |  | 0.81 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5 |  | 0.79 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000407.5 |  | 0.78 | NRPS | plipastatin | Bacillus subtilis subsp. subtilis
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.75 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.74 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.27 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.94 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.35 out of 24.78
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.93 out of 29.25
Confidence: medium
Additional weak hits (16):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.82 out of 39.62
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.16 out of 27.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.82 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.43 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.68 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.11 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.79 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.75 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.42 out of 36.53
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 163563 - 300872:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu) + (D-Orn) + (Tyr - D-Thr) + (Glu) + (D-X) + (Pro - Gln) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 163563 - 240808:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 223705 - 300872:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu) + (D-Orn) + (Tyr - D-Thr) + (Glu) + (D-X) + (Pro - Gln) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
G3T15_RS18595: Asn - Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (268..663): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTITSTKLIVGGDFNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1778..2185): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS18600: Tyr - Asn - Gln - Pro
Search NORINE for peptide: strict or relaxed
AMP-binding (268..662): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
  Nearest Stachelhaus code(s):
    Tyr DALSVGEVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1779..2174): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3288..3693): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASVQQADGLIGGETNVYGPTETCVDASL
  Nearest Stachelhaus code(s):
    Gln DAQDLGVVDK (100% 8Å match)
    Ile DAQDLGVVDK (74% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4337..4733): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LYEAFDVCYQESFLIAAGEHNHYGPSETHVVTMY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS18605: fatty_acid - Asn
Search NORINE for peptide: strict or relaxed
CAL_domain (36..478): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 624.6
  NH2: 18.6
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (2956..3351): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS18610: mal
PKS_AT (6..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 75.7
  inactive: 30.0
  Methoxymalonyl-CoA: 20.4
  Propionyl-CoA: 11.8
  Methylmalonyl-CoA: 11.0
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

G3T15_RS18705: X
AMP-binding (12..445): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
  Nearest Stachelhaus code(s):
    Z-ahmohOrn FGLHIASTCK (56% 8Å match)
    Ile DGLFIGIPVK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

G3T15_RS18725: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (473..866): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
  Nearest Stachelhaus code(s):
    Ile DAFFYGITFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS19900: Pro - Gln
Search NORINE for peptide: strict or relaxed
AMP-binding (469..866): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1901): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
  Nearest Stachelhaus code(s):
    Gln DAWHFGSVEK (100% 8Å match)
    Glu DAWHFGSVEK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS18735: X
AMP-binding (712..1105): X
nrpys: Ala, Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSSFDVTTFEGWLIIGGEWNGYGPTENTTFSTC
  Nearest Stachelhaus code(s):
    Ala or Val DVFWIGGTFK (97% 8Å match)
    Val DVFWIGGTFK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS18740: Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (468..873): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS18745: Tyr - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (474..867): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGSLTSTLITFAGELNEYGPTENSVATTI
  Nearest Stachelhaus code(s):
    Tyr DGTLTAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1509..1905): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHKHFDFSVWEGNQIFGGEVNMYGITETTVHVTC
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS18750: Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (505..910): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    AAWAFDVFSGDRESVLGSDINSYGVTEATIDSSY
  Nearest Stachelhaus code(s):
    Orn DVGEVGSIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

G3T15_RS19905: Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (463..766): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
GnfM | Regulator of nitrogen-fixation genes
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_JAAHBR010000054.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 324,153 - 346,036 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
G3T15_RS19045: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase
G3T15_RS19070: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.47 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.47 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
G3T15_RS19050: T2TS
Domain 1 (5 - 625): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.88 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
Additional weak hits (6):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.37 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.54 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAAHBR010000009.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 67,291 - 88,031 nt. (total: 20,741 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
G3T15_RS08440: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.3 |  | 0.43 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.41 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001374.5 |  | 0.35 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0000937.5 |  | 0.31 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0001007.5 |  | 0.30 | NRPS, PKS | lymphostin, neolymphostinol B, lymphostinol, neolymphostin b | Salinispora arenicola CNS-205
BGC0000254.5 |  | 0.30 | PKS | oxytetracycline | Streptomyces rimosus
BGC0001739.3 |  | 0.29 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001006.5 |  | 0.29 | NRPS, PKS | lymphostin, neolymphostinol B, lymphostinol, neolymphostin B | Salinispora tropica CNB-440
BGC0000190.5 |  | 0.29 | PKS | A-74528 | Streptomyces sp. SANK 61196

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.3 |  | 0.43 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.41 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001374.5 |  | 0.35 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0000937.5 |  | 0.31 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0001007.5 |  | 0.30 | NRPS, PKS | lymphostin, neolymphostinol B, lymphostinol, neolymphostin b | Salinispora arenicola CNS-205
BGC0000254.5 |  | 0.30 | PKS | oxytetracycline | Streptomyces rimosus
BGC0001739.3 |  | 0.29 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001006.5 |  | 0.29 | NRPS, PKS | lymphostin, neolymphostinol B, lymphostinol, neolymphostin B | Salinispora tropica CNB-440
BGC0000190.5 |  | 0.29 | PKS | A-74528 | Streptomyces sp. SANK 61196

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | squalene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
G3T15_RS08445: PT_phytoene_like
Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → squalene
  FPP → PSPP
  FPP → diapophytoene
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47
Confidence: strong
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.23 out of 20.97
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.29 out of 27.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.46 out of 27.78
Confidence: medium
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63
Confidence: medium
Additional weak hits (3):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.91 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
NrtR | NAD synthesis repressor
RutR | Regulator of the pyrimidine and purine metabolism
VqsM | Regulator of quorum-sensing signalling systems