LOCUS       NZ_NJRE01000018        15131 bp    DNA     linear   CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain 18-3 18-3_R1_(paired)_contig_18, whole
            genome shotgun sequence.
ACCESSION   NZ_NJRE01000018
VERSION     NZ_NJRE01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 15131)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 15131)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010578165.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:36:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,453
            CDSs (total)                      :: 4,376
            Genes (coding)                    :: 4,252
            CDSs (with protein)               :: 4,252
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 5, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 5, 2 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 124
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 124
            Pseudo Genes (frameshifted)       :: 72 of 124
            Pseudo Genes (incomplete)         :: 64 of 124
            Pseudo Genes (internal stop)      :: 16 of 124
            Pseudo Genes (multiple problems)  :: 23 of 124
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:28:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 15131
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NJRE01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..15131
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     gene            complement(<1..3842)
                     /locus_tag="CE047_RS22055"
     CDS             complement(<1..3842)
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (2-30). E-value: 3.2e-16.
                     Score: 50.3. Matches aSDomain:
                     nrpspksdomains_CE047_RS22055_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (7-305). E-value:
                     7.9e-119. Score: 388.1. Matches aSDomain:
                     nrpspksdomains_CE047_RS22055_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (469-870). E-value:
                     8.1e-113. Score: 369.0. Matches aSDomain:
                     nrpspksdomains_CE047_RS22055_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (972-1041). E-value: 1e-25. Score:
                     81.7. Matches aSDomain: nrpspksdomains_CE047_RS22055_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1055-1279). E-value:
                     8.8e-78. Score: 253.3. Matches aSDomain:
                     nrpspksdomains_CE047_RS22055_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389714.1"
                     /locus_tag="CE047_RS22055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_163136940.1"
                     /sec_met_domain="Condensation (E-value: 6.2e-93, bitscore:
                     298.8, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.8e-123, bitscore:
                     399.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.8e-17, bitscore:
                     50.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTINGQL
                     DLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPVYVEDISHLNEKDKEHC
                     TEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDFLHI
                     YQALGKGQFPDLPPVQPYGTYITWLMQQDREEAAEYWKKRLQHFEKASPLPKRTDQMSD
                     GTLQQITFTIPEKETSELQKIAAACGATLNTVFQALWGIMLQKFNRRDDAVFGSVISGR
                     PSELKDVENMVGLFINTIPIRVQSDFLSFSDLVSGMQKDMTEAEAYSYFPLYDIQAQSA
                     LKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYRCSVKVIPGRTLYV
                     RIHFHTGTYQPNMMSEIKDYLQHLISDVISDPSLPVSKMTLLDEDKTRKIVSQNNRTVS
                     VSPEAPTLHGLFERQAAVTPERPAIRFSGGSLTYTELDMYANRLAAHLAARGVTNESIV
                     GILSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSAPSF
                     SGETLEVDMTSLDREEVKRYVSASVSDGSLAYVIYTSGSTGQPKGVAVEHRQAVSFLTG
                     MQHQFPLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVKAIHQE
                     NVTTAHFIPAMLNSFLDQAEMLALGDGANLKRVFAGGEPLAPRTAARFASILPQVSLIH
                     GYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGELYIA
                     GAGVARGYLNRPALTEERFLKDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIRG
                     YRIEPEEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGYMV
                     PAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKNGPV
                     GIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLATVIREGTDSPYEA
                     IKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFKELIKR
                     HESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAFIKPFDLSQAPLFRA
                     QIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYNNRKLPALRIQYKDYAVWQEGF
                     KTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEVASGL"
     source          1..15131
                     /collection_date="2016-07"
                     /db_xref="taxon:1423"
                     /geo_loc_name="China"
                     /mol_type="genomic DNA"
                     /note="commercial probiotic used for animal"
                     /organism="Bacillus subtilis"
                     /strain="18-3"
                     /submitter_seqid="18-3_R1_(paired)_contig_18"
     cand_cluster    1..15131
                     /SMILES="NC(CCCN)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(O)C)C(=O)NC
                     (CCC(=O)O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..15131
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:>15127](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..>15127)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     aSDomain        complement(6..677)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22055_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="8.80E-78"
                     /label="CE047_RS22055_Condensation_LCL.1"
                     /locus_tag="CE047_RS22055"
                     /protein_end="1279"
                     /protein_start="1055"
                     /score="253.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIISDG"
                     /tool="antismash"
                     /translation="ETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRA
                     FKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAFIKPFDLS
                     QAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYNNRKLPALRIQYKDY
                     AVWQEGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEVA
                     SG"
     CDS_motif       complement(174..203)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0013"
                     /evalue="1.20E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="CE047_RS22055"
                     /protein_end="1223"
                     /protein_start="1213"
                     /score="14.7"
                     /tool="antismash"
                     /translation="QYKDYAVWQE"
     CDS_motif       complement(234..299)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0012"
                     /evalue="4.70E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="CE047_RS22055"
                     /protein_end="1203"
                     /protein_start="1181"
                     /score="31.9"
                     /tool="antismash"
                     /translation="MHHIISDGVSVNILIREFGELY"
     CDS_motif       complement(498..605)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0011"
                     /evalue="6.50E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="CE047_RS22055"
                     /protein_end="1115"
                     /protein_start="1079"
                     /score="53.9"
                     /tool="antismash"
                     /translation="YNMPAVLELEGKLNPERMDRAFKELIKRHESLRTSF"
     aSDomain        complement(720..926)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22055_PCP.1"
                     /evalue="1.00E-25"
                     /label="CE047_RS22055_PCP.1"
                     /locus_tag="CE047_RS22055"
                     /protein_end="1041"
                     /protein_start="972"
                     /score="81.7"
                     /tool="antismash"
                     /translation="EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFD
                     VQVPLKDVFAHPTVEGLATVIREG"
     aSModule        complement(720..3821)
                     /complete
                     /domains="nrpspksdomains_CE047_RS22055_Condensation_DCL.1"
                     /domains="nrpspksdomains_CE047_RS22055_AMP-binding.1"
                     /domains="nrpspksdomains_CE047_RS22055_PCP.1"
                     /locus_tags="CE047_RS22055"
                     /monomer_pairings="Glu -> Glu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(1203..1268)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0010"
                     /evalue="5.30E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="CE047_RS22055"
                     /protein_end="880"
                     /protein_start="858"
                     /score="37.6"
                     /tool="antismash"
                     /translation="FLGRTDDQVKIRGYRIEPEEIE"
     aSDomain        complement(1233..2435)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22055_AMP-binding.1"
                     /evalue="8.10E-113"
                     /label="CE047_RS22055_AMP-binding.1"
                     /locus_tag="CE047_RS22055"
                     /protein_end="870"
                     /protein_start="469"
                     /score="369.0"
                     /specificity="substrate consensus: Glu"
                     /tool="antismash"
                     /translation="FERQAAVTPERPAIRFSGGSLTYTELDMYANRLAAHLAARGVTNE
                     SIVGILSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSA
                     PSFSGETLEVDMTSLDREEVKRYVSASVSDGSLAYVIYTSGSTGQPKGVAVEHRQAVSF
                     LTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVKAI
                     HQENVTTAHFIPAMLNSFLDQAEMLALGDGANLKRVFAGGEPLAPRTAARFASILPQVS
                     LIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGEL
                     YIAGAGVARGYLNRPALTEERFLKDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVK
                     IR"
     CDS_motif       complement(1350..1439)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0009"
                     /evalue="7.90E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="CE047_RS22055"
                     /protein_end="831"
                     /protein_start="801"
                     /score="56.5"
                     /tool="antismash"
                     /translation="PSGVAGELYIAGAGVARGYLNRPALTEERF"
     CDS_motif       complement(1965..2024)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0008"
                     /evalue="5.60E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="CE047_RS22055"
                     /protein_end="626"
                     /protein_start="606"
                     /score="34.1"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGQPKGVAVEH"
     CDS_motif       complement(2208..2249)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0007"
                     /evalue="8.20E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="CE047_RS22055"
                     /protein_end="545"
                     /protein_start="531"
                     /score="18.9"
                     /tool="antismash"
                     /translation="LAVLKAGGAYLPLD"
     CDS_motif       complement(2775..2891)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0006"
                     /evalue="1.60E-18"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="CE047_RS22055"
                     /protein_end="356"
                     /protein_start="317"
                     /score="59.1"
                     /tool="antismash"
                     /translation="QKDMTEAEAYSYFPLYDIQAQSALKQELIDHIIVFENTP"
     aSDomain        complement(2928..3821)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22055_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="7.90E-119"
                     /label="CE047_RS22055_Condensation_DCL.1"
                     /locus_tag="CE047_RS22055"
                     /protein_end="305"
                     /protein_start="7"
                     /score="388.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHILMDG"
                     /tool="antismash"
                     /translation="QDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTINGQLDLERFQK
                     SMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPVYVEDISHLNEKDKEHCTEAFKEQ
                     DKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDFLHIYQALGKG
                     QFPDLPPVQPYGTYITWLMQQDREEAAEYWKKRLQHFEKASPLPKRTDQMSDGTLQQIT
                     FTIPEKETSELQKIAAACGATLNTVFQALWGIMLQKFNRRDDAVFGSVISGRPSELKDV
                     ENMVGLFINTIPIRVQS"
     CDS_motif       complement(2937..3032)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0005"
                     /evalue="1.20E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="CE047_RS22055"
                     /protein_end="302"
                     /protein_start="270"
                     /score="62.7"
                     /tool="antismash"
                     /translation="DAVFGSVISGRPSELKDVENMVGLFINTIPIR"
     CDS_motif       complement(3267..3305)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0004"
                     /evalue="1.30E-02"
                     /label="C4_DCL_171-183"
                     /locus_tag="CE047_RS22055"
                     /protein_end="192"
                     /protein_start="179"
                     /score="8.6"
                     /tool="antismash"
                     /translation="PYGTYITWLMQQD"
     CDS_motif       complement(3351..3416)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0003"
                     /evalue="8.60E-11"
                     /label="C3_DCL_135-156"
                     /locus_tag="CE047_RS22055"
                     /protein_end="164"
                     /protein_start="142"
                     /score="34.2"
                     /tool="antismash"
                     /translation="HHHILMDGWCLGIVIKDFLHIY"
     CDS_motif       complement(3633..3749)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0002"
                     /evalue="2.40E-17"
                     /label="C2_DCL_024-062"
                     /locus_tag="CE047_RS22055"
                     /protein_end="70"
                     /protein_start="31"
                     /score="55.2"
                     /tool="antismash"
                     /translation="AYFEQASFTINGQLDLERFQKSMDAVFDRYDIFRTAFIY"
     aSDomain        complement(3753..3836)
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22055_NRPS-COM_Nterm.1"
                     /evalue="3.20E-16"
                     /label="CE047_RS22055_NRPS-COM_Nterm.1"
                     /locus_tag="CE047_RS22055"
                     /protein_end="30"
                     /protein_start="2"
                     /score="50.3"
                     /tool="antismash"
                     /translation="QQPEIQDIYPLSFMQEGMLFHSLYDEQS"
     CDS_motif       complement(3771..3812)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22055_0001"
                     /evalue="8.20E-05"
                     /label="C1_DCL_004-017"
                     /locus_tag="CE047_RS22055"
                     /protein_end="24"
                     /protein_start="10"
                     /score="14.6"
                     /tool="antismash"
                     /translation="YPLSFMQEGMLFHS"
     gene            complement(3859..11541)
                     /gene="ppsB"
                     /locus_tag="CE047_RS22060"
     CDS             complement(3859..11541)
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (0-29). E-value: 1.6e-15.
                     Score: 48.0. Matches aSDomain:
                     nrpspksdomains_CE047_RS22060_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (7-309). E-value:
                     2e-111. Score: 363.9. Matches aSDomain:
                     nrpspksdomains_CE047_RS22060_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (474-865). E-value:
                     1.9e-110. Score: 361.2. Matches aSDomain:
                     nrpspksdomains_CE047_RS22060_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (970-1035). E-value: 6e-23. Score:
                     72.8. Matches aSDomain: nrpspksdomains_CE047_RS22060_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1054-1341). E-value:
                     2e-103. Score: 337.5. Matches aSDomain:
                     nrpspksdomains_CE047_RS22060_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1505-1903). E-value:
                     4.9e-119. Score: 389.5. Matches aSDomain:
                     nrpspksdomains_CE047_RS22060_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2011-2078). E-value: 2.7e-20.
                     Score: 64.3. Matches aSDomain:
                     nrpspksdomains_CE047_RS22060_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (2088-2392). E-value:
                     3.3e-157. Score: 516.4. Matches aSDomain:
                     nrpspksdomains_CE047_RS22060_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (2403-2553). E-value: 1.1e-52.
                     Score: 169.9. Matches aSDomain:
                     nrpspksdomains_CE047_RS22060_TIGR01720.1"
                     /codon_start=1
                     /gene="ppsB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389715.1"
                     /locus_tag="CE047_RS22060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plipastatin non-ribosomal peptide synthetase
                     PpsB"
                     /protein_id="WP_163136942.1"
                     /sec_met_domain="Condensation (E-value: 8.8e-96, bitscore:
                     308.1, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-127, bitscore:
                     413.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3e-17, bitscore:
                     50.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGNL
                     CVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQEQQ
                     ALIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILKEFF
                     SMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRIRRRT
                     AEGDYKAAQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDAVFGSV
                     ISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGYYPLYEI
                     QNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNYDFNIVIV
                     PGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPPEEQQVIQS
                     FNETERPYVNKTIPQLFEEQARKTPEAAALKMGDERWTYRQLNIRANQIAHALIEKGVG
                     SGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQAAQLLIEEDL
                     ISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKGVLVDHHGIANT
                     LQWRREEYGMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDDEAKDVLALKRKI
                     ARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLELSQMICPSAELAN
                     EYGPTENSVATTILRHLNEKERITIGHPIRNTKVFVLHGNQMQPIGAAGELCISGAGLA
                     KGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIGRFDDQVKIRGYRIEL
                     REIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLPDLYQHLAGTLPSYMIP
                     ASIINISRMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEADLAHIWEDVLNKQHIGI
                     RDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVESMAGKLMSLKEHAFTQIE
                     PADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRGSLNRQRLRSVLTELVNRHE
                     ALRTVFVLDRDEPVQIIYPEIAFDLKELEMESEQMLESAIETFIKPFDLSSGPLFRACV
                     ITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGKELPALNLHYKDFAVWQQEKHP
                     KELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFSGGTIEVNIDKDTADELHRLMAE
                     TGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRPHADLERVIGMFVNTLAMRSKPEG
                     HKTFSSYLQDIRHLALTAYEHQDYPFEELADKLDTNREINRNPLFDAMLVLQSSEDFRF
                     EVPGLSISSVTPKHDISKFDLTLHAEEHPSGIRCRFEYSTALFEEETITQWASYFIELV
                     KGVTADTEMRISDMQLLPAAERRLLLEKMGQYAAYPRNENIVSLFEKQAAKYPEHIAVV
                     CGHSQLTYRDLNEKAERAAAMLIKQGVRTGDIVGLMLDRSPDMIIGILSILKAGGAYLP
                     IDPEYPKERISFMLNDSGAKRLLTERGQNKPADYTGHILYIDECENDSIPADVNIQEIV
                     TDQPAYVIYTSGTTGQPKGVIVEHRNVISLLKHQNLPFEFNHEDVWTLFHSYCFDFSVW
                     EMFGALLNGGTLVVVSKETARDPHAFRLLLKKERVTVLNQTPTAFYGLMLEDQNHTDHL
                     SIRYVIFGGEALQPGLLQSWNKKYPHIDLINMYGITETTVHVTFKKLSAADIAKNKSNI
                     GRPLSTLQAYVMDAHMNLQPIGVPGELYIGGEGVARGYLNRDELTADRFVSNPYLPGDR
                     LYRTGDLAKRLSNGELEYLGRIDEQVKVRGHRIELGEIQAALLQYPMIKEAAVITRADE
                     QGQTAIYAYMVIKDQQAANISDIRTYLKNALPDFMLPARMIQIDSIPVTVNGKLDQKAL
                     PEPEKHAYTADDISPRNEIETVMAEIWEELLNVDELGVSANFFELGGDSIKALQVCARL
                     KQRGFETTVREMFEYQTLGELSARVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHH
                     FNQSVMIYRAERFDEAALRKVLKSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYA
                     LELFDVKDSLTEARYTIEEAASRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVD
                     AVSWRILFEDFSAAYKQAVSGKSIKLPQKTDSYLTYSQRIVDYSKSRQVQREAAYWDEC
                     ESRHIQPIPKDNDAAYNTFKDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGL
                     ALQKWTGNNQFKISMEGHGRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLG
                     HLIKQTKDMLHRIPHKGAGYGVLKYISKRWGSEKNSTEISFNYLGQFDQDIQSNAFEVS
                     DIKPGNEISPNWERPYALDISGAVSSGCLNMHIIYNRHQFEEETIQTFAGHFKQTLENI
                     IEHCTGKENREWSASDFTDEDLTLDELSEIMGAVNKL"
     aSDomain        complement(3883..4332)
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_TIGR01720.1"
                     /evalue="1.10E-52"
                     /label="CE047_RS22060_TIGR01720.1"
                     /locus_tag="CE047_RS22060"
                     /protein_end="2553"
                     /protein_start="2403"
                     /score="169.9"
                     /tool="antismash"
                     /translation="LGHLIKQTKDMLHRIPHKGAGYGVLKYISKRWGSEKNSTEISFNY
                     LGQFDQDIQSNAFEVSDIKPGNEISPNWERPYALDISGAVSSGCLNMHIIYNRHQFEEE
                     TIQTFAGHFKQTLENIIEHCTGKENREWSASDFTDEDLTLDELSEI"
     aSModule        complement(3883..8379)
                     /complete
                     /domains="nrpspksdomains_CE047_RS22060_Condensation_LCL.1"
                     /domains="nrpspksdomains_CE047_RS22060_AMP-binding.2"
                     /domains="nrpspksdomains_CE047_RS22060_PCP.2"
                     /domains="nrpspksdomains_CE047_RS22060_Epimerization.1"
                     /domains="nrpspksdomains_CE047_RS22060_TIGR01720.1"
                     /locus_tags="CE047_RS22060"
                     /monomer_pairings="Thr -> D-Thr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(4252..4311)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0025"
                     /evalue="4.90E-08"
                     /label="NRPS-E6"
                     /locus_tag="CE047_RS22060"
                     /protein_end="2430"
                     /protein_start="2410"
                     /score="25.3"
                     /tool="antismash"
                     /translation="TKDMLHRIPHKGAGYGVLKY"
     aSDomain        complement(4366..5277)
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_Epimerization.1"
                     /evalue="3.30E-157"
                     /label="CE047_RS22060_Epimerization.1"
                     /locus_tag="CE047_RS22060"
                     /protein_end="2392"
                     /protein_start="2088"
                     /score="516.4"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVVDA"
                     /tool="antismash"
                     /translation="EGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVLK
                     SLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARYTIEEAASR
                     MQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSAAYKQAVSGKS
                     IKLPQKTDSYLTYSQRIVDYSKSRQVQREAAYWDECESRHIQPIPKDNDAAYNTFKDTE
                     VIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGHGRESY
                     LEDIDISRTVGWFTSIYPVWLDM"
     CDS_motif       complement(4372..4422)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0024"
                     /evalue="5.10E-09"
                     /label="NRPS-E5"
                     /locus_tag="CE047_RS22060"
                     /protein_end="2390"
                     /protein_start="2373"
                     /score="28.0"
                     /tool="antismash"
                     /translation="DISRTVGWFTSIYPVWL"
     CDS_motif       complement(4825..4890)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0023"
                     /evalue="1.60E-11"
                     /label="NRPS-E2"
                     /locus_tag="CE047_RS22060"
                     /protein_end="2239"
                     /protein_start="2217"
                     /score="36.3"
                     /tool="antismash"
                     /translation="LFLTIHHLVVDAVSWRILFEDF"
     CDS_motif       complement(5113..5178)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0022"
                     /evalue="1.60E-03"
                     /label="C2_LCL_024-062"
                     /locus_tag="CE047_RS22060"
                     /protein_end="2143"
                     /protein_start="2121"
                     /score="10.9"
                     /tool="antismash"
                     /translation="RFDEAALRKVLKSLVTHHDALR"
     CDS_motif       complement(5236..5262)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0021"
                     /evalue="2.90E-03"
                     /label="NRPS-E1"
                     /locus_tag="CE047_RS22060"
                     /protein_end="2102"
                     /protein_start="2093"
                     /score="10.8"
                     /tool="antismash"
                     /translation="WTPIQQWFF"
     aSDomain        complement(5308..5508)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_PCP.2"
                     /evalue="2.70E-20"
                     /label="CE047_RS22060_PCP.2"
                     /locus_tag="CE047_RS22060"
                     /protein_end="2078"
                     /protein_start="2011"
                     /score="64.3"
                     /tool="antismash"
                     /translation="ETVMAEIWEELLNVDELGVSANFFELGGDSIKALQVCARLKQRGF
                     ETTVREMFEYQTLGELSARVRK"
     CDS_motif       complement(5803..5868)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0020"
                     /evalue="3.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1913"
                     /protein_start="1891"
                     /score="35.3"
                     /tool="antismash"
                     /translation="YLGRIDEQVKVRGHRIELGEIQ"
     aSDomain        complement(5833..7026)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_AMP-binding.2"
                     /evalue="4.90E-119"
                     /label="CE047_RS22060_AMP-binding.2"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1903"
                     /protein_start="1505"
                     /score="389.5"
                     /specificity="substrate consensus: Thr"
                     /tool="antismash"
                     /translation="FEKQAAKYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTG
                     DIVGLMLDRSPDMIIGILSILKAGGAYLPIDPEYPKERISFMLNDSGAKRLLTERGQNK
                     PADYTGHILYIDECENDSIPADVNIQEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL
                     LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGGTLVVVSKETARDPHAFRLLL
                     KKERVTVLNQTPTAFYGLMLEDQNHTDHLSIRYVIFGGEALQPGLLQSWNKKYPHIDLI
                     NMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAYVMDAHMNLQPIGVPGELYIG
                     GEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQVKVR"
     CDS_motif       complement(5950..6039)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0019"
                     /evalue="3.10E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1864"
                     /protein_start="1834"
                     /score="57.8"
                     /tool="antismash"
                     /translation="PIGVPGELYIGGEGVARGYLNRDELTADRF"
     CDS_motif       complement(6154..6177)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0018"
                     /evalue="2.50E+00"
                     /label="NRPS-A_a5"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1796"
                     /protein_start="1788"
                     /score="2.0"
                     /tool="antismash"
                     /translation="YGITETTV"
     CDS_motif       complement(6556..6615)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0017"
                     /evalue="4.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1662"
                     /protein_start="1642"
                     /score="31.4"
                     /tool="antismash"
                     /translation="AYVIYTSGTTGQPKGVIVEH"
     CDS_motif       complement(6799..6840)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0016"
                     /evalue="1.70E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1581"
                     /protein_start="1567"
                     /score="15.0"
                     /tool="antismash"
                     /translation="LSILKAGGAYLPID"
     CDS_motif       complement(7360..7473)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0015"
                     /evalue="8.70E-15"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1394"
                     /protein_start="1356"
                     /score="47.0"
                     /tool="antismash"
                     /translation="LALTAYEHQDYPFEELADKLDTNREINRNPLFDAMLVL"
     aSDomain        complement(7519..8379)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.00E-103"
                     /label="CE047_RS22060_Condensation_LCL.1"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1341"
                     /protein_start="1054"
                     /score="337.5"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIIADG"
                     /tool="antismash"
                     /translation="VYPLSFSQKRLYALHQLADDSTGYNMPAVLELRGSLNRQRLRSVL
                     TELVNRHEALRTVFVLDRDEPVQIIYPEIAFDLKELEMESEQMLESAIETFIKPFDLSS
                     GPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGKELPALNLHYKDFA
                     VWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFSGGTIEVNIDKDTAD
                     ELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRPHADLERVIGMFVNTL
                     AMRSKP"
     CDS_motif       complement(7528..7617)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0014"
                     /evalue="8.90E-17"
                     /label="C5_LCL_267-296"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1338"
                     /protein_start="1308"
                     /score="53.4"
                     /tool="antismash"
                     /translation="DIVVGSPAAGRPHADLERVIGMFVNTLAMR"
     CDS_motif       complement(7876..7908)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0013"
                     /evalue="3.60E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1222"
                     /protein_start="1211"
                     /score="13.2"
                     /tool="antismash"
                     /translation="HYKDFAVWQQE"
     CDS_motif       complement(7939..8004)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0012"
                     /evalue="1.90E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1201"
                     /protein_start="1179"
                     /score="30.0"
                     /tool="antismash"
                     /translation="MHHIIADGVSMSTLVQEFTDLY"
     CDS_motif       complement(8200..8310)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0011"
                     /evalue="1.30E-16"
                     /label="C2_LCL_024-062"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1114"
                     /protein_start="1077"
                     /score="52.9"
                     /tool="antismash"
                     /translation="YNMPAVLELRGSLNRQRLRSVLTELVNRHEALRTVFV"
     aSDomain        complement(8437..8631)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_PCP.1"
                     /evalue="6.00E-23"
                     /label="CE047_RS22060_PCP.1"
                     /locus_tag="CE047_RS22060"
                     /protein_end="1035"
                     /protein_start="970"
                     /score="72.8"
                     /tool="antismash"
                     /translation="EADLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLN
                     VELPLSEVFSYPTVESMAGK"
     aSModule        complement(8437..11520)
                     /complete
                     /domains="nrpspksdomains_CE047_RS22060_Condensation_DCL.1"
                     /domains="nrpspksdomains_CE047_RS22060_AMP-binding.1"
                     /domains="nrpspksdomains_CE047_RS22060_PCP.1"
                     /locus_tags="CE047_RS22060"
                     /monomer_pairings="Tyr -> Tyr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(8917..8982)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0010"
                     /evalue="4.20E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="CE047_RS22060"
                     /protein_end="875"
                     /protein_start="853"
                     /score="34.8"
                     /tool="antismash"
                     /translation="YIGRFDDQVKIRGYRIELREIE"
     aSDomain        complement(8947..10119)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_AMP-binding.1"
                     /evalue="1.90E-110"
                     /label="CE047_RS22060_AMP-binding.1"
                     /locus_tag="CE047_RS22060"
                     /protein_end="865"
                     /protein_start="474"
                     /score="361.2"
                     /specificity="substrate consensus: Tyr"
                     /tool="antismash"
                     /translation="FEEQARKTPEAAALKMGDERWTYRQLNIRANQIAHALIEKGVGSG
                     DIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQAAQLLIEEDLIS
                     LIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKGVLVDHHGIANTLQ
                     WRREEYGMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDDEAKDVLALKRKIAR
                     YKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLELSQMICPSAELANEY
                     GPTENSVATTILRHLNEKERITIGHPIRNTKVFVLHGNQMQPIGAAGELCISGAGLAKG
                     YYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIGRFDDQVKIR"
     CDS_motif       complement(9064..9153)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0009"
                     /evalue="3.90E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="CE047_RS22060"
                     /protein_end="826"
                     /protein_start="796"
                     /score="41.6"
                     /tool="antismash"
                     /translation="PIGAAGELCISGAGLAKGYYKQQELTQKAF"
     CDS_motif       complement(9250..9282)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0008"
                     /evalue="1.20E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="CE047_RS22060"
                     /protein_end="764"
                     /protein_start="753"
                     /score="5.7"
                     /tool="antismash"
                     /translation="EYGPTENSVAT"
     CDS_motif       complement(9655..9714)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0007"
                     /evalue="1.60E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="CE047_RS22060"
                     /protein_end="629"
                     /protein_start="609"
                     /score="29.8"
                     /tool="antismash"
                     /translation="AYLIYTSGTTGRPKGVLVDH"
     CDS_motif       complement(9892..9933)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0006"
                     /evalue="6.80E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="CE047_RS22060"
                     /protein_end="550"
                     /protein_start="536"
                     /score="16.1"
                     /tool="antismash"
                     /translation="LGIWKAGGAYMPLD"
     CDS_motif       complement(10459..10575)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0005"
                     /evalue="3.10E-19"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="CE047_RS22060"
                     /protein_end="361"
                     /protein_start="322"
                     /score="61.4"
                     /tool="antismash"
                     /translation="QEDILSSEQHGYYPLYEIQNHSPLKQGLIDHIFVFENYP"
     aSDomain        complement(10615..11520)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="2.00E-111"
                     /label="CE047_RS22060_Condensation_DCL.1"
                     /locus_tag="CE047_RS22060"
                     /protein_end="309"
                     /protein_start="7"
                     /score="363.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIIMDG"
                     /tool="antismash"
                     /translation="QDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGNLCVDSFQK
                     SLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQEQQALIDAFM
                     TKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILKEFFSMYDSLK
                     NNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRIRRRTAEGDYKA
                     AQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDAVFGSVISGRPSA
                     IDGIESMVGLFINTVPVRIRS"
     CDS_motif       complement(10624..10719)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0004"
                     /evalue="2.40E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="CE047_RS22060"
                     /protein_end="306"
                     /protein_start="274"
                     /score="61.7"
                     /tool="antismash"
                     /translation="DAVFGSVISGRPSAIDGIESMVGLFINTVPVR"
     CDS_motif       complement(11044..11109)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0003"
                     /evalue="2.50E-11"
                     /label="C3_DCL_135-156"
                     /locus_tag="CE047_RS22060"
                     /protein_end="166"
                     /protein_start="144"
                     /score="35.9"
                     /tool="antismash"
                     /translation="HHHIIMDGWCLGIILKEFFSMY"
     CDS_motif       complement(11335..11448)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0002"
                     /evalue="2.10E-14"
                     /label="C2_DCL_024-062"
                     /locus_tag="CE047_RS22060"
                     /protein_end="69"
                     /protein_start="31"
                     /score="45.7"
                     /tool="antismash"
                     /translation="AYIEQTSFTITGNLCVDSFQKSLNLLVSRYDIFRTIFI"
     aSDomain        complement(11455..11541)
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22060_NRPS-COM_Nterm.1"
                     /evalue="1.60E-15"
                     /label="CE047_RS22060_NRPS-COM_Nterm.1"
                     /locus_tag="CE047_RS22060"
                     /protein_end="29"
                     /protein_start="0"
                     /score="48.0"
                     /tool="antismash"
                     /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFS"
     CDS_motif       complement(11470..11511)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22060_0001"
                     /evalue="9.00E-05"
                     /label="C1_DCL_004-017"
                     /locus_tag="CE047_RS22060"
                     /protein_end="24"
                     /protein_start="10"
                     /score="14.5"
                     /tool="antismash"
                     /translation="YPLSHMQEGMLFHS"
     CDS             complement(11566..>15127)
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (129-534). E-value: 1.2e-97.
                     Score: 319.0. Matches aSDomain:
                     nrpspksdomains_CE047_RS22065_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (639-703). E-value: 2.6e-21. Score:
                     67.6. Matches aSDomain: nrpspksdomains_CE047_RS22065_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (715-1026). E-value:
                     1.3e-147. Score: 484.7. Matches aSDomain:
                     nrpspksdomains_CE047_RS22065_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1034-1179). E-value: 1.2e-46.
                     Score: 150.3. Matches aSDomain:
                     nrpspksdomains_CE047_RS22065_TIGR01720.1"
                     /codon_start=3
                     /gene="ppsA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389716.2"
                     /locus_tag="CE047_RS22065"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="plipastatin non-ribosomal peptide synthetase
                     PpsA"
                     /pseudo=""
                     /sec_met_domain="AMP-binding (E-value: 4.1e-107, bitscore:
                     345.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-15, bitscore:
                     45.5, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.1e-87, bitscore:
                     281.5, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="TRDMSRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDI
                     TLIATEISGSICCEMEFSTEVFLKATIERWADHFIEFLHEALSTPETNLAQINILSDKE
                     KQKIVFEFNKTQVEFAQKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLA
                     RTLQNRKGPKPTVAVLAKRSIDAIVGVLAVMKAGGVYIPIDSHYPKARIEYILRDSGAD
                     ILLLQRELKHLISNFPESEMSHICLDDESTYEESNCNLNLSPAPEEPVYIIYTSGTTGA
                     PKGVIVTYQNFTHAALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVC
                     PDETRLEPAEIYKIMNSRRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKA
                     QDFKTLTDRFGQSMRIINSYGVTEATIDSSFYETSMSGECTGDNVPIGSPLPNVRMYVL
                     SQTDQIQPIGVAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLP
                     NGTIRLLGRMDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVP
                     SDVNTNALRAALTKELPAYMIPAHLIPLENMPLTLNGKLDRNALPAPNNVLSRPYTAPV
                     NDMQKTMAYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYS
                     TIQELCGHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNA
                     NALHLALRKITEHHDAIRMIFQHDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERA
                     HLDEKLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDL
                     AAAYQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKPYWQTILDAHTAFLPKD
                     IENVPDRLQKNSDAAAFVLSGDWTEKLQFETQQAYGTDANELLLTALGMALSEWTGHDH
                     IVISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR
                     VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEADTFQLSYYQPRHEIAGERERE
                     YELDINALITDGRLQVKAVYTQVFSKHSIEYFMDRFHRHLIETIEHCSQKKAREKTLSD
                     FSNKELTLSALSSIEDLVKDL"
     gene            complement(11566..>15131)
                     /gene="ppsA"
                     /locus_tag="CE047_RS22065"
                     /pseudo=""
     aSDomain        complement(11590..12024)
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22065_TIGR01720.1"
                     /evalue="1.20E-46"
                     /label="CE047_RS22065_TIGR01720.1"
                     /locus_tag="CE047_RS22065"
                     /protein_end="1179"
                     /protein_start="1034"
                     /score="150.3"
                     /tool="antismash"
                     /translation="LAYRIKTTKDMLRRVPNKGTGYGLLTHIGELRHKEPEVSFNYLGQ
                     FSEEKEADTFQLSYYQPRHEIAGEREREYELDINALITDGRLQVKAVYTQVFSKHSIEY
                     FMDRFHRHLIETIEHCSQKKAREKTLSDFSNKELTLSALSS"
     aSModule        complement(11590..14739)
                     /complete
                     /domains="nrpspksdomains_CE047_RS22065_AMP-binding.1"
                     /domains="nrpspksdomains_CE047_RS22065_PCP.1"
                     /domains="nrpspksdomains_CE047_RS22065_Epimerization.1"
                     /domains="nrpspksdomains_CE047_RS22065_TIGR01720.1"
                     /locus_tags="CE047_RS22065"
                     /monomer_pairings="Orn -> D-Orn"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(11944..12003)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0010"
                     /evalue="8.70E-09"
                     /label="NRPS-E6"
                     /locus_tag="CE047_RS22065"
                     /protein_end="1061"
                     /protein_start="1041"
                     /score="27.6"
                     /tool="antismash"
                     /translation="TKDMLRRVPNKGTGYGLLTH"
     aSDomain        complement(12049..12981)
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22065_Epimerization.1"
                     /evalue="1.30E-147"
                     /label="CE047_RS22065_Epimerization.1"
                     /locus_tag="CE047_RS22065"
                     /protein_end="1026"
                     /protein_start="715"
                     /score="484.7"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVIDG"
                     /tool="antismash"
                     /translation="EGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHLAL
                     RKITEHHDAIRMIFQHDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDEKLA
                     AEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAAYQQA
                     LEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKPYWQTILDAHTAFLPKDIENVPDR
                     LQKNSDAAAFVLSGDWTEKLQFETQQAYGTDANELLLTALGMALSEWTGHDHIVISTEG
                     HGREGHVPNIDISRTVGWFTSIYPILLDMG"
     CDS_motif       complement(12058..12108)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0009"
                     /evalue="4.20E-09"
                     /label="NRPS-E5"
                     /locus_tag="CE047_RS22065"
                     /protein_end="1023"
                     /protein_start="1006"
                     /score="28.3"
                     /tool="antismash"
                     /translation="DISRTVGWFTSIYPILL"
     CDS_motif       complement(12514..12579)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0008"
                     /evalue="2.40E-11"
                     /label="NRPS-E2"
                     /locus_tag="CE047_RS22065"
                     /protein_end="871"
                     /protein_start="849"
                     /score="35.8"
                     /tool="antismash"
                     /translation="LLIALHHLVIDGVSWRILLEDL"
     CDS_motif       complement(12805..12876)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0007"
                     /evalue="2.00E-02"
                     /label="C2_LCL_024-062"
                     /locus_tag="CE047_RS22065"
                     /protein_end="774"
                     /protein_start="750"
                     /score="7.3"
                     /tool="antismash"
                     /translation="FNANALHLALRKITEHHDAIRMIF"
     CDS_motif       complement(12940..12966)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0006"
                     /evalue="4.20E-03"
                     /label="NRPS-E1"
                     /locus_tag="CE047_RS22065"
                     /protein_end="729"
                     /protein_start="720"
                     /score="10.3"
                     /tool="antismash"
                     /translation="LTPIQRRFF"
     aSDomain        complement(13018..13209)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22065_PCP.1"
                     /evalue="2.60E-21"
                     /label="CE047_RS22065_PCP.1"
                     /locus_tag="CE047_RS22065"
                     /protein_end="703"
                     /protein_start="639"
                     /score="67.6"
                     /tool="antismash"
                     /translation="KTMAYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWS
                     MTIRDLFRYSTIQELCGHI"
     CDS_motif       complement(13267..13398)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0005"
                     /evalue="1.20E+00"
                     /label="C2_LCL_024-062"
                     /locus_tag="CE047_RS22065"
                     /protein_end="620"
                     /protein_start="576"
                     /score="1.7"
                     /tool="antismash"
                     /translation="SDVNTNALRAALTKELPAYMIPAHLIPLENMPLTLNGKLDRNAL"
     CDS_motif       complement(13495..13557)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0004"
                     /evalue="2.30E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="CE047_RS22065"
                     /protein_end="544"
                     /protein_start="523"
                     /score="29.4"
                     /tool="antismash"
                     /translation="LGRMDYQVKINGYRIETEEIE"
     aSDomain        complement(13525..14739)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS22065_AMP-binding.1"
                     /evalue="1.20E-97"
                     /label="CE047_RS22065_AMP-binding.1"
                     /locus_tag="CE047_RS22065"
                     /protein_end="534"
                     /protein_start="129"
                     /score="319.0"
                     /specificity="substrate consensus: Orn"
                     /tool="antismash"
                     /translation="FEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKP
                     TVAVLAKRSIDAIVGVLAVMKAGGVYIPIDSHYPKARIEYILRDSGADILLLQRELKHL
                     ISNFPESEMSHICLDDESTYEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNF
                     THAALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEI
                     YKIMNSRRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG
                     QSMRIINSYGVTEATIDSSFYETSMSGECTGDNVPIGSPLPNVRMYVLSQTDQIQPIGV
                     AGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGRMD
                     YQVKIN"
     CDS_motif       complement(13642..13731)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0003"
                     /evalue="1.20E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="CE047_RS22065"
                     /protein_end="495"
                     /protein_start="465"
                     /score="46.4"
                     /tool="antismash"
                     /translation="PIGVAGELCIGGAGVAKGYHHKPDLTQMKF"
     CDS_motif       complement(14263..14316)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0002"
                     /evalue="1.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="CE047_RS22065"
                     /protein_end="288"
                     /protein_start="270"
                     /score="24.1"
                     /tool="antismash"
                     /translation="YIIYTSGTTGAPKGVIVT"
     CDS_motif       complement(14515..14556)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS22065_0001"
                     /evalue="7.00E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="CE047_RS22065"
                     /protein_end="204"
                     /protein_start="190"
                     /score="16.1"
                     /tool="antismash"
                     /translation="LAVMKAGGVYIPID"
ORIGIN
        1 tgaaggcctg atgcaacctc tggttccagc gtaaatgaga ccttgtcacc cgcgaagctt
       61 cgcaccggcg ggcgggcatg atcagccgga agatccagca caggcagctc gccctcgagc
      121 tgcttcagcc agtacgcctc ctgcgttttg tacgcgtctc ctgttttaaa tccttcttgc
      181 catacggcat aatctttata ttgaatgcgc agtgccggaa gcttccgatt attgtacagc
      241 tcgccgaatt cccgaatcag aatgttgacg gaaacaccgt ctgaaatgat gtgatgcata
      301 tcaaccagca acaggtgccg ctcatctgat acctttacga tttgggcacg gaacagcggc
      361 gcttggctga gatcaaacgg tttgataaag gcggctgcgg cctcctgttc ggttcgttcg
      421 ccgagaactg tagtctgtaa cgtaaacggc acctcgtcat ggatgcgctg caccggatcg
      481 cctcctgcgt cctgttcgaa ggaggtacga agcgactcgt ggcgcttgat cagctctttg
      541 aaagctctgt ccatcctttc agggttgagc ttcccttcga gctctaacac agccggcata
      601 ttgtagcctg tccctccgtc ctccagctgc tgaaggacat aaatccgctt ttgggcagag
      661 gaaaccggat aggtttcctg tttttcagcg ggcttaatcg cttcatatgg actgtccgtt
      721 ccttcacgga taacggtagc cagcccttcg actgtcggat gggcaaatac atcttttagc
      781 ggcacctgta catcgaattc tttggcaatc cgtgagacaa gcgccgttgc ttttaaggaa
      841 tgtcccccgc ggtcaaaaaa gttgtcgtga atcccgacag ggccattttt cagcacgtcc
      901 tcccacagct gagaaagctt catctcagtc acgtttctcg gcgctgtgta ggtctccgca
      961 tctgccgctc cgccaggagc tggcagggcg tttcggtcga gttttccgct tggcgtaacc
     1021 ggccactgtt ccatctctat catataggct gggaccatgt agcccggcaa cagtctctca
     1081 agctgtgccc gcacttcgtt tctttggagc ccttctacat aagcgcataa ttccggctcg
     1141 ccgctgtctg tccgtacggt aacggccgcc tcccttacgc cttctatgct tcttagtgcc
     1201 gcttcaattt cttccggctc aatccggtag ccgcggattt tcacctgatc atccgtgcgc
     1261 ccgaggaatt caacattccc gtcagggagc cagcgcgcca catccccggt tttgtacatg
     1321 cgttcacccg ggtaaaacgg gtccttaaga aaacgctcct ccgttaatgc cggccgattc
     1381 aaataacctc tggcaacacc cgctccggca atgtacagtt cgccggcgac accagaaggc
     1441 tgtacggcta aatgtggatc taaaacatac aaacgcgcac cgggtacggg cttcccaatc
     1501 ggaatccgca aacggtccct gtcccgttct gggtccaaca cgtaaaatgc cgcgtctacc
     1561 gttgcttctg tcggcccgta gccatggatt aatgatacct gcggcaagat agaagcaaaa
     1621 cgggctgccg tacgcggcgc aagcggttca cctccggcga atacacgctt taggtttgcc
     1681 ccgtcaccga gcgctaacat ttccgcttga tctagaaagc tgttcagcat agccggaata
     1741 aaatgagccg ttgtcacgtt ttcctgatga atggctttta cgatcaatgc ggagtctttt
     1801 tcccagccgg gcggaagcag atacgccgaa gcaccggaaa gagcccacca aaacagctgc
     1861 cacacagacg catcaaagga aaaagaggtt ttcaccatga cgatgtcatc ttctgaaagc
     1921 ggaaactggt gctgcatgcc ggtcagaaaa gaaacagcct ggcggtgctc aacggccact
     1981 cctttcggct gcccggtaga gcccgatgta tagatgacat aggcgagaga tccgtcgcta
     2041 acagaagcag acacataacg ttttacttct tcacgatcaa gagatgtcat gtcaacttca
     2101 agcgtctctc cagaaaagct cggtgcggag catcccggct gtgtcagcaa gagcgatgcc
     2161 ccgctgtctt tcagcatgta gctcagccgc tcctttggat acgcaggatc aagcggcaaa
     2221 tacgcccctc cggccttcaa tacagcaagg acagcgatca gcatgtcagg tgagcgttca
     2281 gacaggatac cgacgatact ttcgtttgtg acgccgcgtg ccgcaaggtg cgcagccagc
     2341 cggttggcgt acatgtcaag ctcagtgtat gtcagcgaac cgccggaaaa tcggatagct
     2401 ggccgctccg gtgtgactgc cgcctgtcgt tcaaacagcc catgcagggt tggggcttca
     2461 ggtgaaacag atactgtcct gttattttga gaaacgattt tccgtgtttt gtcctcatct
     2521 agcaatgtca tctttgacac aggaagagat ggatcagaga tgacgtcaga gatcaagtgc
     2581 tgtaaataat cttttatttc ggacatcata tttggttgat aagtgcctgt atgaaaatga
     2641 atccgaacgt acaaagtacg ccctgggatc actttgacac tgcatctata attagttacc
     2701 tcttccatct caaaatcttt cacggagaaa tcaaatgatc cagcttgatt cagctcttca
     2761 atctcttgtt gagtaggtgt attttcaaag acgataatat gatcaatcag ctcttgttta
     2821 agagcgctct gcgcctgaat gtcatataaa gggaagtaac tatacgcttc tgcttcagtc
     2881 atgtcctttt gcattccgct gactaggtca gaaaaagaca gaaaatcact ttggactcga
     2941 ataggaatgg tattgataaa aagtccgacc atgttttcca catcttttag ctcagaaggt
     3001 ctgcctgata taactgatcc gaatacagca tcgtcgcggc gattgaactt ttggagcatg
     3061 attccccata aagcttggaa aacagtgtta agtgtcgcac cacatgctgc agcgattttc
     3121 tgtaattcgg aggtttcttt ttcaggaatg gtaaacgtga tctgctgtaa tgtcccatcc
     3181 gacatttgat ctgttctttt aggcagaggt gaagcttttt cgaaatgctg aagcctcttt
     3241 ttccaatact cagctgcttc ttcccggtct tgctgcatca gccatgtaat atacgtcccg
     3301 tacggctgta cgggaggcaa atcaggaaac tgcccttttc caagcgcttg ataaatatgg
     3361 agaaagtctt taatgacgat gcctaaacac cagccatcca ttaaaatatg atggtggctc
     3421 cagatacaga cataatgatc aggcgcccat tttaaaatag atattctcat caatacatcc
     3481 gtttggagat caaagccttt tgatttgtcc tgttctttga atgcctctgt acaatgttct
     3541 ttatcttttt cattgaggtg agaaatatct tcaacataaa cagggcaatg acgttgcttg
     3601 agcacgactt gacgaggttt ggctacattt ttatagatga atgctgttcg aaagatatcg
     3661 tacctgtcaa aaacagcatc catacttttc tggaaacgct ccaagtcaag ctgtccattg
     3721 atcgtaaaag aagcctgttc aaaataagct ctcgactgct catcatacaa tgagtgaaaa
     3781 agcatccctt cctgcataaa tgacaaaggg tatatatcct gtatttcagg ttgctgcggc
     3841 atcagtgaat ctcctctcct atagtttgtt gacggctccc atgatctcac tcaattcatc
     3901 aagcgttaag tcttcatcag tgaaatcaga tgcgctccac tctcggtttt ctttgcccgt
     3961 acaatgctca atgatatttt ccagagtctg tttaaaatgc ccggcaaatg tttgaatggt
     4021 ttcttcctca aattgatgtc tgttatagat gatgtgcatg ttcaggcacc ccgaagaaac
     4081 ggcgccgctg atatccagtg cataaggacg ctcccagttc gggctgatct catttcctgg
     4141 cttgatgtca gacacctcaa aggcatttga ttgaatatcc tgatcaaact ggcctaaata
     4201 attaaagctg atttctgtgc tgtttttctc agagccccat cttttgctga tatatttcag
     4261 cacgccgtag cccgcgcctt tatgcggtat acggtgcagc atatcttttg tctgtttaat
     4321 aaggtggccc agccgctctt ctttgtcctt atgatcggaa tctctcatat caagccacac
     4381 aggataaata gaggtgaacc agccaacagt tctgctaata tcgatgtcct caagatatga
     4441 ttcccttccg tggccctcca tgctgatttt aaattggtta tttcccgtcc atttctgcaa
     4501 agcaagacct aaagctgtca gaaggatatc attcatctcc gtgctgtaag ctttatgtgc
     4561 agccgttagt agtaattctg tgtgatggcg agatagctca aaatcaatca cttctgtatc
     4621 tttgaatgtg ttatatgctg cgtcattgtc ttttggaata ggctggatgt gacggctctc
     4681 gcactcatcc cagtacgctg cttcgcgctg cacctggcgg cttttagagt agtcaactat
     4741 tctttgtgaa tacgttaaat atgaatctgt tttttgcggc agtttaatag attttcctga
     4801 gactgcctgt ttgtaagcag ctgaaaaatc ctcgaacaaa atgcgccagg aaaccgcatc
     4861 aacaactaag tgatgaatcg tcagaaataa atggtcacca ttctcggttc taaacaatcc
     4921 agcgtgaagt aaggggccgg tttccaaacg aatatgttct tgcatccggc tggctgcttc
     4981 ctcaatcgtg taccgtgctt ctgttaggct atcctttaca tcaaacagtt caagtgcata
     5041 tagctcctca tctgaaagat ctatccctct gtttatctgc acctgcctgc catcttcatg
     5101 ccggcatacg attctcagtg catcatgatg agtcacaagg ctttttagta cttttctaag
     5161 cgcagcctca tcaaatcgtt cagcccggta gatcataacg gactggttaa aatgatggct
     5221 ttccagagat tgcgagaaaa accactgctg gataggtgtc caagtaatct cgccttcgac
     5281 cgggccttgg tcaatggcgc gtacgtcttt tcgaacccgg gcggacagtt caccaagagt
     5341 ctgatattca aacatctcac gtactgtcgt ttcaaatccg cgctgcttca gtctggcaca
     5401 aacctgcagc gctttaatag agtctccgcc aagctcaaag aaattggcgc ttacacccag
     5461 ctcatctaca ttaagaagct cctcccaaat ttcagccatc accgtttcaa tctcatttct
     5521 aggactgata tcatcagctg tataagcgtg tttttcaggc tctggcaggg ctttctgatc
     5581 gagctttcca ttaacagtca ccgggatgct gtcaatttgt atcatacggg caggcagcat
     5641 aaagtcaggc aaggcgtttt ttaggtaagt tcggatgtct gatatattcg cagcctgttg
     5701 atcttttatc accatatatg catatatagc tgtttgccct tgctcgtctg ctctggtaat
     5761 gacagccgcc tctttaatca ttggatactg aagaagtgcc gcttggattt cgcctaactc
     5821 aatacggtgc cctctgactt tcacctgctc atcaatgcgg cctaagtatt ccagctcgcc
     5881 atttgacagg cgcttagcaa gatctcctgt tcggtataat ctgtctcccg gaagataagg
     5941 attggataca aaacggtcag cggtcagctc atctctgttg agatatcccc gtgccacacc
     6001 ttcgccgcct atatacagct cccctggaac tccgatcggc tgcagattca tatgagcatc
     6061 catcacataa gcctgcagag ttgaaagcgg ccgtccgata ttgcttttat tttttgcaat
     6121 gtctgctgcg gacaattttt tgaatgttac atggaccgtt gtttctgtaa taccgtacat
     6181 attaatcaaa tcaatatgag gatatttttt attccagctt tgaagcaatc cgggctgtaa
     6241 ggcttcgccg ccaaaaatca catagcggat gcttaaatga tctgtatgat tttgatcttc
     6301 aagcatcaag ccgtaaaaag cagtcggggt ctgattgagt acagttacgc gctctttttt
     6361 taacaataaa cggaatgcat gggggtcacg ggctgtttct ttagagacca cgactaatgt
     6421 acctccgttc aatagtgcac cgaacatctc ccatacagag aaatcaaagc aataagaatg
     6481 aaataacgtc cagacgtctt catggttaaa ttcaaaaggc aggttttgat gcttcaagag
     6541 actgatcaca ttgcggtgct cgacaatgac gccctttggc tggccagtcg ttccagatgt
     6601 gtatatcacg tatgcgggct gatccgttac tatttcttga atgtttacat cagccggaat
     6661 tgagtcgttt tcacattcat cgatatacaa aatatgcccg gtgtagtctg caggtttgtt
     6721 ttgaccgcgc tctgtcagca gccgttttgc tccgctgtca ttgagcataa agctaatacg
     6781 ctccttggga tattcaggat caatcggcaa ataggcccct ccagctttta aaatcgataa
     6841 aatgccaatg atcatatcag gtgaccgatc gagcatcaga ccgacgatat ccccagttct
     6901 caccccttgt ttgatcagca tagcagctgc ccgctcggct ttttcattca ggtctcgata
     6961 cgtaagctga gaatggccgc acactactgc gatatgctcc ggatatttag cggcttgctt
     7021 ttcaaataag cttactatgt tttcatttct cggataagcc gcatactgtc ccattttttc
     7081 aaggagcaac ctacgctctg cagcaggaag caattgcatg tccgaaattc tcatctcggt
     7141 atccgccgtt acccctttca ccaattcaat aaaataggat gcccactgcg taatggtttc
     7201 ttcttcaaaa agagcagtgc tgtattcaaa acggcagcgt attccactcg gatgctcctc
     7261 agcgtgtaat gttaaatcga atttagatat atcatgttta ggagtgacag acgaaatcga
     7321 cagaccaggc acttcgaacc ggaaatcttc actgctttga agcacaagca tcgcatcgaa
     7381 cagcgggttg cgatttatct ctcgatttgt atcgagctta tctgccagct cctcaaaagg
     7441 ataatcctga tgctcgtaag cggtcagagc caggtggcga atgtcctgca aataggagct
     7501 gaacgttttg tggccctcgg gcttgctgcg catcgccaat gtattgacga acatcccgat
     7561 gacgcgctcc agatcagcgt gcggtcttcc ggcagcaggc gaaccgacaa caatatcctc
     7621 ttgcccgctt agcttagata acaaaataga atagacagcc agaagaatca tatacaatgt
     7681 tgttcccgtt tcagccatta aacggtgcag ttcatcagcc gtgtctttat caatgttgac
     7741 ttcaattgtt ccaccgctga aatcagggag acgcggcctt gttttatcaa gcggtaattc
     7801 tagtgtagga agactcccgc caagctgacc aagccagtag gcctcctgtt ttttgtatag
     7861 ctctttcggg tgcttctctt gctgccaaac agcaaaatcc ttataatgca ggtttaaagc
     7921 tggcaactct tttccgcaat ataagtcagt aaattcttgg acaagagtgc tcatcgagac
     7981 accgtcggca ataatatggt gcatatcgag cagcaaaaag ccgcgattat tgcccattgt
     8041 aatgacacat gctctaaaaa gcggaccgga tgatagatca aacggtttga taaaggtctc
     8101 gattgcagac tcaagcattt gttctgattc catttcaagc tcttttagat caaaagctat
     8161 ctctgggtaa atgatctgca caggctcgtc tctgtcaagc acaaaaacag tccgtaatgc
     8221 ttcatgccga ttcacaagtt ctgtgagaac gcttctcaac cgctggcgat tcagacttcc
     8281 gcgtaattca agtacagctg gcatgttata acctgtgctg tcatctgcca gctgatgaag
     8341 agcatataat cgtttttgcg agaaagacag cggatagaca tctctttgat ccgcaggttc
     8401 aatctgtgta aaagcgtgtt cttttaagct catcaatttg cccgccatgc tttcaaccgt
     8461 cggataagaa aacacctcac tgagcggcag ctcgacatta agctttttat gtattcttga
     8521 taccagtgcg gccgctttta aggactgtcc gcctaactga aagaaatcat cacgaatgcc
     8581 gatgtgctgt ttattcagca catcctccca tatatgtgcg agatcagctt cgattaaggt
     8641 tcggggcgcc atatatgtga cactcgtatt gttttctggt tcaggaagcg caaacctgtc
     8701 aagcttgccg ctggatgtta atggcatccg gctgatgttg ataatacttg ctgggatcat
     8761 ataggacggc aatgtcccgg caagatgctg atacaaatct gggaggctgt ttcccttttc
     8821 tggaacgata taagcaacaa gctccttttc ctcagcagaa acatcacggg ccagtaccgc
     8881 ggcttccttt acccccggtg cttgtcgaag aactgtttca atctctctca gttcaatacg
     8941 gtaaccccta atttttactt gatcatcaaa acgtccaata tattcaatcg ttccatcagg
     9001 caagaagcgg cctgcatcac ctgttcggta taaacgctcc ccttcaagga atggatgatc
     9061 agagaatgct ttctgtgtca gctcttgctg tttgtagtat cctttcgcaa gacccgcgcc
     9121 ggaaatacac agttcacccg ccgcgccgat cggctgcatt tgatttccgt gcaaaacaaa
     9181 tacttttgtg tttctgatcg ggtgtccgat cgtaatcctc tctttttcat tcagatgccg
     9241 caatattgtt gttgccacac tgttttctgt gggcccgtat tcatttgcca gttctgcaga
     9301 aggacaaatc atttgactca actcaagcag atcaggcgtg accgcttcac ccgcaaatgt
     9361 cacaatacga agactttttg catcgtcagc agtcatcact tccaataaca ccctgtacag
     9421 ggaaggaaca atgatcatgt ggctgacctt ataacgagct atttttcgct taagggccag
     9481 cacatccttc gcttcgtcat ctgttgtcag cagtacgcac gcaccagata aaagcggggt
     9541 aaataagctc gttacacagc cgtcaaacac gtacgaaaac aaatggaggg atatatcctg
     9601 ttcggtcatg ccatactctt cccgtctcca ttgcaatgta ttggcaatac cgtgatgatc
     9661 aactaaaacc cctttagggc gccccgtcgt tcccgacgta tagatcaagt aggctaggtc
     9721 acctggcggc atatttggcg cttctgtttg gtaactttct gtatgttcta tcgttatcgt
     9781 atttccttca taggacggag ggatcaaaga aataaggtct tcttctatca gcaattgagc
     9841 cgcttgactg tccttcagca ggaaagaaag acgttctgct ggaaaatgtg gatcaagcgg
     9901 catataagcg ccgcctgctt tccaaatccc aagcagagct gcaggcattt ccattgaccg
     9961 gcccatcatt acagcaacga tatctccaga tccaacgcct ttttctatca gggcgtgcgc
    10021 aatctgattg gctcttatat ttaattggcg ataggtccag cgctcgtctc ccatttttaa
    10081 tgctgccgct tcaggtgttt tgcgggcttg ttcctcgaac aattggggta tcgttttgtt
    10141 cacataagga cgctcagttt cgttaaacga ttggataacc tgttgctcct ccggcggcac
    10201 gatattgatg tcactgacgg caacatcggg atttgtcaaa atgcaatcca gtgcttgctt
    10261 tagatgcccc tgaatcctca gcatctcctc ccgctcgtaa acgtctgcgt tgtagctgaa
    10321 tttgatataa aatgattctc ccggaacgat aacgatatta aagtcgtaat tggtttgttc
    10381 cgacattgaa atgtcactca gcttcagagc gccttcgtca ttttcactct ccacgcttaa
    10441 tgcctgatga agctgtacag ggtaattttc aaaaacaaaa atatgatcga tcaacccttg
    10501 cttcaatgga ctatggtttt gaatctcata aagcggataa tagccatgct gttcagatga
    10561 taaaatatcc tcctgtacgg ctttgaccag cgaagaaaac gttatgcctt ccgcagatcg
    10621 gattcgcact ggaacagtat tgataaacaa gccgaccatt gattcaatcc cgtcaatcgc
    10681 tgacgggcgt cccgaaatga cggagccaaa aacggcatca tctgcagcat tatatcgatg
    10741 gagcagcacg ccccaaatac tcataaacag cgtgtttaat gtcactcccc agttttgggc
    10801 agcctctgtc agtttctcaa ccatatccgg cgctaatgaa aagctgacct gggcggcttt
    10861 ataatccccc tctgccgtgc ggcgccttat tcggggaata gaagcagtat tgccgtactc
    10921 ctttaaatat tcgctccagt aggcagcagt ctcttcttga tcttgttctc cgagccattc
    10981 aatataacgg ctgtacggca ccgtgctgcc aagctgtaca ggtgagttat ttttgagcga
    11041 atcatacatg ctgaaaaact ctttaagaat aatgccgaga caccacccat ccatgatgat
    11101 atggtgatgt gtccagacac atgtatattg gctgtctcct ctatcaaaaa gggcaagacg
    11161 cattaaagga tctttttgca aatcaaatcc tttttcccga tccttagtca taaaagcatc
    11221 aatcagcgcc tgctgttctt gatcagccag gcgagaaata tcttctctat atactgtcaa
    11281 ttcccggttt gataagacta cctgctgcgg acctgtaaga tctggtactt ctttaatgaa
    11341 aatcgttctg aaaatatcat atctagaaac aagaaggttt aagctctttt gaaacgagtc
    11401 gacgcataga ttccctgtga tcgtaaacga ggtctgttcg atatatgctt tcgagctgaa
    11461 atccattagt gaatgaaaca gcattccttc ctgcatgtgc gataacggat aaatatcttg
    11521 aatttgtgcc gattgtgcca tcaattccac acaccttttc aaaagttaaa gatctttcac
    11581 gagatcttcg atgctagata atgcagacaa cgttaattcc ttattgctga aatcgctcag
    11641 tgttttttcg cgtgcttttt tctgcgaaca atgctcaatc gtctcgataa gatgcctgtg
    11701 aaaacgatcc ataaagtact caattgagtg cttgctgaac acctgggtgt ataccgcttt
    11761 tacttgaagc cgtccgtccg taatgagagc attgatgtcc agctcatact ctcgttctct
    11821 ctcacccgct atttcgtgac ggggctggta atatgataat tgaaacgtat cagcttcctt
    11881 ctcttcgcta aattgaccga gataattaaa gctgacctca ggctctttat gccgcagttc
    11941 tcctatgtgt gttaacaatc catatccagt tcctttgttc ggtactcttc tcagcatatc
    12001 ttttgtcgtc ttaattcggt atgcgagctg atcctcgaaa ggctcgggaa tacccatgtc
    12061 tagcagaata ggataaatgg aagtaaacca tccaacggtc cttgaaatat caatgtttgg
    12121 cacatgccct tctctgccgt gtccctcagt gctgatcacg atatggtcat gccctgtcca
    12181 ttcagaaagc gccattccta aagccgtaag caaaagttcg ttggcatcag taccataggc
    12241 ttgctgggtt tcaaactgca atttttcagt ccagtccccg gatagtacaa acgctgctgc
    12301 gtcgctgttc ttttggagtc tgtccggcac attttctatg tccttaggaa gaaaagcagt
    12361 gtgagcgtct aaaatcgttt gccaatacgg tttctctgaa agcaattgtt tactttcagc
    12421 tatttgggta agaccatcgg cgtaggataa ataagaatcc gtttttggcg gtaattggat
    12481 ttctttcttt tctaaagcct gttgatatgc tgcagctaaa tcttcaagca gaattctcca
    12541 agaaacgcca tctatcacaa gatgatgaag tgcaatcagc aaatgatccc cttctgccgt
    12601 tttaaacaag cctgcttgca gcaaaggccc tttttctaca ttcattttgc tttgaatgac
    12661 ggtttcctca gcggcaagtt tttcatcaag atgagccctt tccagcgatg cttttgtcca
    12721 atctgaaata taaaggccaa acagttcatg atccttgtga ttgattccgc gattaaactg
    12781 aatgacatgg ccgttttggt catgttggaa aatcatgcga atggcatcat gatgctcggt
    12841 tattttacgc agcgctagat gaagcgcgtt agcattgaat cctttttcac tgaaaagcat
    12901 gacggactgg ttgtaatgat agtgaaaagc atgtacctgt ccgaaaaatc ttcgctgaat
    12961 cggggtgagt tcagcttcac cttccgcagg tccctggtcc gcttgagatg ccaatggtgt
    13021 gatatgtccg catagttcct gaatcgttga ataacggaat aagtcgcgta ttgtcatgct
    13081 ccagccttca gctgccagac gtgctgccac ttgtaatgct ttaattgagt ctccgccaag
    13141 ctcaaaaaag gaatcgtgaa tgccgactcg tgacatgctc agtacatctt cccatatata
    13201 cgccatcgtt ttttgcatgt cgttaactgg tgcggtatat ggacgcgata acacattatt
    13261 tggagccggc aaggcatttc tgtccagctt tccgtttagg gttagcggca tgttttctaa
    13321 aggaatcaga tgtgcaggaa tcatatacgc tggcagctcc tttgttaaag cagcacggag
    13381 agcattcgta ttgacgtctg aaggcacaat atatgctgcc aaaccagcct gtccattctt
    13441 atcatgctga acggcaacag cagcttctct gacaagtccc gtttgaagca gaacactttc
    13501 aatttcttct gtttcaattc tgtatccatt tatctttact tgataatcca ttcggccaag
    13561 aagccggatc gttccgtttg gaagccagca tgctcgatca ccggttctgt acagcctttc
    13621 tccagagaca aatggatttt ctgtaaattt catttgcgtt aagtcaggtt tatgatgata
    13681 gcctttcgca acacctgccc cgccgatgca cagctcgccg gcaacgccga tcggctgaat
    13741 ttgatcagtc tggctgagta cgtacatgcg tacattcggc agcgggctgc cgattggtac
    13801 gttatcgccc gtacactctc cactcatact tgtttcataa aagctcgaat caatggttgc
    13861 ctctgtgaca ccatagctat taatgatgcg catgctttga ccaaagcgat ctgtcaatgt
    13921 tttgaaatct tgagctttca ccatgtcgga accaagaatc agtatgtcta agtcaggaag
    13981 cttgaactga ttacggtata catactccat caccgggata atgagagccg gtgtcgactc
    14041 catcaccgtg attctccgag agttcatgat tttatatatt tcagcaggtt ccagccgtgt
    14101 ttcatctggg caaacgatta gagtcccgcc gttggtcaat gttctcgcca aatctcctga
    14161 gaagacatcg aatgaaaagc tcgcgatttg aagcagtctg acaggcttcc gatccagttc
    14221 ataaatttga cgccaagcaa gagcagcatg agtaaagttc tgataggtga caataacacc
    14281 tttaggcgca cccgtcgttc ctgacgtata aatgatatat accggctctt caggagcagg
    14341 agataagtta aggttgcagt tactttcttc ataagtgctt tcatcgtcaa ggcagatatg
    14401 agacatctca gattcaggaa agtttgaaat caaatgcttc aactctctct gtaaaagaag
    14461 aatatctgcc ccgctatcac gaagaatgta ttcaatacgg gcttttggat aatgtgaatc
    14521 gattgggata tacactccgc cagctttcat cactgccagc accccaacaa ttgcatcgat
    14581 ggaccgcttg gctaaaacag ccacagttgg cttcggtcct tttctgtttt gcaatgttcg
    14641 tgccagacga ttggctcttt catttagaag ccgatagcta atctctgttt cgttatcaat
    14701 aacagctata tgttctggat tttcttcagc tttcgcttca aatatgcgat gaaaaggaat
    14761 atctttttga gcaaattcaa cttgagtttt gttaaattca aagactattt tttgtttttc
    14821 tttatcacta agtatgttta tttgtgcaag gtttgtttca ggagttgaaa gtgcctcatg
    14881 cagaaattcg ataaaatgat cagcccagcg ttcaatcgta gctttcagga atacttctgt
    14941 actaaattcc atttcgcagc aaatagatcc acttatttcc gtagctatta atgtgatatc
    15001 aaataaggaa atgtgatgtg cgaaattggc aggccggact tttatttctc tcagatctat
    15061 gtcttgtttt tccacatttt gaaggataaa catcgcatca aacactggat tccggctcat
    15121 atcccgtgtc a
//
