LOCUS       NZ_NJRE01000005        22760 bp    DNA     linear   CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain 18-3 18-3_R1_(paired)_contig_5, whole
            genome shotgun sequence.
ACCESSION   NZ_NJRE01000005
VERSION     NZ_NJRE01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 1011869)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1011869)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010578165.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:36:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,453
            CDSs (total)                      :: 4,376
            Genes (coding)                    :: 4,252
            CDSs (with protein)               :: 4,252
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 5, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 5, 2 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 124
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 124
            Pseudo Genes (frameshifted)       :: 72 of 124
            Pseudo Genes (incomplete)         :: 64 of 124
            Pseudo Genes (internal stop)      :: 16 of 124
            Pseudo Genes (multiple problems)  :: 23 of 124
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:28:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 989109
            Orig. end                         :: 1011869
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NJRE01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22760
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="4"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..22760
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22760
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:>22760](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..>22760
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            157..1050
                     /gene="proC"
                     /locus_tag="CE047_RS15155"
     CDS             157..1050
                     /EC_number="1.5.1.2"
                     /GO_function="GO:0004735 - pyrroline-5-carboxylate
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="proC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389730.2"
                     /locus_tag="CE047_RS15155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="WP_080481277.1"
                     /transl_table=11
                     /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQN
                     ICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRIQP
                     HQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKKLAE
                     ALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSIGAQT
                     LLGAAKMLMETGEHPKILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAKRSKEI
                     SEDIEKTAAPLSGVIK"
     gene            1047..2162
                     /gene="proB"
                     /locus_tag="CE047_RS15160"
     CDS             1047..2162
                     /EC_number="2.7.2.11"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004349 - glutamate 5-kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="proB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389729.1"
                     /locus_tag="CE047_RS15160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate 5-kinase"
                     /protein_id="WP_163136339.1"
                     /transl_table=11
                     /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQIVKLKDAG
                     YEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVASQI
                     LITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVAGLI
                     DADMLVILSDIDGLYDGNPRTNPEAKRIQRVSEITPDIEAFAGDTGSIVGTGGMRSKLD
                     AFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEKWIAFNSGPEG
                     KMFLSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVNYSSVQL
                     QEPEKKKELTNRALIDQEAFVCHVDFSLPVN"
     gene            complement(2213..3115)
                     /gene="gltC"
                     /locus_tag="CE047_RS15165"
     CDS             complement(2213..3115)
                     /codon_start=1
                     /gene="gltC"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389728.2"
                     /locus_tag="CE047_RS15165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate biosynthesis transcriptional regulator
                     GltC"
                     /protein_id="WP_004399246.1"
                     /transl_table=11
                     /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNV
                     TLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLASQ
                     LLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKILFT
                     EKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEG
                     EDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPS
                     ANDFYEFVIQFFSKLEQYQ"
     misc_feature    3135..3149
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 22.93"
                     /tool="antismash"
     gene            3261..7823
                     /gene="gltB"
                     /locus_tag="CE047_RS15170"
     CDS             3261..7823
                     /EC_number="1.4.1.13"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0015930 - glutamate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006537 - glutamate biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="gltB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389727.2"
                     /locus_tag="CE047_RS15170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate synthase large subunit"
                     /protein_id="WP_163136341.1"
                     /transl_table=11
                     /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHTIVKQGLKM
                     LCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKDINLPEKERYGVGMVFFSQKEDE
                     RKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGANSDLKDNLS
                     FERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEAFVSA
                     FALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFGEDLNK
                     ILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRAFYEYHS
                     SLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIEVEQENVL
                     YKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDPESREEEQF
                     SDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQSLFNYFKQLF
                     AQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSNEQFYALKTIV
                     HPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNERLTPIPPLLAV
                     SALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLAYATYKQEIDEGR
                     LDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGISRDVIDRYFTGTA
                     SQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEHHAFNPKTIHTLQWA
                     CRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVESAESIVKRFKTGAMSF
                     GSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDRRSAIKQIASGRFGVKS
                     HYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVAEVRGSTPGVGLISPPPHHDIYSIE
                     DLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATADVIVISGYDGGTGASPKTS
                     IKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGRDVVMAALLGAEEFGFATAP
                     LVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHIVNYMLFIAEEVREYMAALGF
                     KTFDEMIGRTDVLHVSERAKGHWKASQLDLSTLLYQPEGVRTFRSPQNHKIDQSLDITT
                     ILPAVQEAIESGKEADISIEINNTNRVAGTITGSEISKRYGEEGLPEDTIKLHFTGSAG
                     QSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKSPEGFNSASDDNVIIGNVAFYGAT
                     SGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEYMTGGSVVVLGDVGKNFAAGMSGGI
                     AYVLAEDVKAFKRKCNLEMILFESLEDEKEIQQIKAMLERHTAYTNSQKAEDLLDQWED
                     SVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEAIMFAFEANTKPKQNTAASGQKQAVVQ
                     "
     gene            7840..9321
                     /gene="gltD"
                     /locus_tag="CE047_RS15175"
     CDS             7840..9321
                     /EC_number="1.4.1.-"
                     /GO_component="GO:0009342 - glutamate synthase complex
                     (NADPH) [Evidence IEA]"
                     /GO_function="GO:0045181 - glutamate synthase activity,
                     NAD(P)H as acceptor [Evidence IEA]"
                     /GO_process="GO:0006537 - glutamate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gltD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1285: ferredoxin fdxC"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389726.2"
                     /locus_tag="CE047_RS15175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate synthase small subunit"
                     /protein_id="WP_014476983.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.8e-27, bitscore:
                     91.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGAR
                     CMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFTGR
                     VCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGSGPA
                     GLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGIDFVTN
                     TEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKSYLDSN
                     FKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTNDNMWPE
                     QPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVKNEHGKYE
                     FRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVDSVNNKISAAYGDYQTNIDGVFAA
                     GDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP"
     misc_feature    7858..7871
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.8"
                     /tool="antismash"
     gene            complement(9378..10367)
                     /gene="yogA"
                     /locus_tag="CE047_RS15180"
     CDS             complement(9378..10367)
                     /NRPS_PKS="Domain: PKS_ER (15-324). E-value: 4.7e-40.
                     Score: 129.6. Matches aSDomain:
                     nrpspksdomains_CE047_RS15180_PKS_ER.1"
                     /codon_start=1
                     /gene="yogA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389725.1"
                     /locus_tag="CE047_RS15180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_103804368.1"
                     /sec_met_domain="ADH_N (E-value: 1.4e-12, bitscore: 43.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.6e-27, bitscore:
                     92.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDLF
                     LMKNKSEQDPHVILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPEIL
                     GGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEQLLI
                     PGIGSGVATYALLMAKAIGATVSVTSRSEEKRKRALQLGADYTFDSYSNWDDQLQGKKI
                     DVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTSMGSGE
                     EFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME"
     aSDomain        complement(9396..10322)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS15180_PKS_ER.1"
                     /evalue="4.70E-40"
                     /label="CE047_RS15180_PKS_ER.1"
                     /locus_tag="CE047_RS15180"
                     /protein_end="324"
                     /protein_start="15"
                     /score="129.6"
                     /tool="antismash"
                     /translation="SVQDVPSTKPGYGEVKVKLKSAGLNHRDLFLMKNKSEQDPHVILG
                     SDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPEILGGPSDGTLAEYVIIP
                     SQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEQLLIPGIGSGVATYALLMA
                     KAIGATVSVTSRSEEKRKRALQLGADYTFDSYSNWDDQLQGKKIDVVLDSIGPALFSEY
                     FRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTSMGSGEEFQAMLAFIDKHKLR
                     PVIDRIYPLEKACEAYKRMQEGRQFGNI"
     gene            10496..11353
                     /gene="yofA"
                     /locus_tag="CE047_RS15185"
     CDS             10496..11353
                     /codon_start=1
                     /gene="yofA"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389724.1"
                     /locus_tag="CE047_RS15185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator YofA"
                     /protein_id="WP_125121264.1"
                     /transl_table=11
                     /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLNI
                     RLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETTAVTH
                     LPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVSHDE
                     LVLISSREGTSEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAIIKGV
                     SAGMGTALLPKSAVNCSEHRTNVWIHQLPPAYQDLEIVFIYRKDFFITSAFQTFLDEIN
                     EMKR"
     gene            complement(11515..13278)
                     /gene="ggt"
                     /locus_tag="CE047_RS15190"
     CDS             complement(11515..13278)
                     /EC_number="2.3.2.2"
                     /GO_function="GO:0036374 - glutathione hydrolase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006750 - glutathione biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006751 - glutathione catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ggt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1274: gamma-glutamyltranspeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389723.1"
                     /locus_tag="CE047_RS15190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gamma-glutamyltransferase"
                     /protein_id="WP_014476980.1"
                     /transl_table=11
                     /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVGK
                     DGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDGKT
                     KDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDKWGT
                     RSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGDTLIQ
                     KDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPIWGDYQ
                     GYQIATTPPPSSGGIFLLQMLKILDDFNLSQYDVRSWEKYQLLAETMHLSYADRASYAG
                     DPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQVEQPKDKV
                     EGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIPGGANEVQP
                     NKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELKAAVEEPRIY
                     TNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGTFKGVADSSRN
                     GAAIGINLKRK"
     misc_feature    complement(13318..13334)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.85"
                     /tool="antismash"
     misc_feature    complement(13352..13370)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            13463..13693
                     /gene="yoeD"
                     /locus_tag="CE047_RS15195"
     CDS             13463..13693
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="yoeD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389722.1"
                     /locus_tag="CE047_RS15195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="excisionase family DNA-binding protein"
                     /protein_id="WP_003231472.1"
                     /transl_table=11
                     /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQFK
                     THLEQLENYKALVQEILNEPIPEDIDVKDED"
     gene            14009..14554
                     /gene="yoeC"
                     /locus_tag="CE047_RS15200"
     CDS             14009..14554
                     /codon_start=1
                     /gene="yoeC"
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389721.2"
                     /locus_tag="CE047_RS15200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /protein_id="WP_159376829.1"
                     /transl_table=11
                     /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDIL
                     PLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMRENEYLFKSVRTRKPI
                     SRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSITMRY
                     IGIDEDTTRAAYKVFGGL"
     tRNA            14607..14679
                     /anticodon=(pos:1003749..1003751,aa:Arg,seq:cct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CE047_RS15205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Arg"
     gene            14607..14679
                     /locus_tag="CE047_RS15205"
     gene            complement(14775..15320)
                     /gene="iseA"
                     /locus_tag="CE047_RS15210"
     CDS             complement(14775..15320)
                     /codon_start=1
                     /gene="iseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389720.2"
                     /locus_tag="CE047_RS15210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DL-endopeptidase inhibitor IseA"
                     /protein_id="WP_163136343.1"
                     /transl_table=11
                     /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSAREH
                     FWNTMSGHNPKVKKAFCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEKGF
                     KDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAKRKV
                     TFVKENKKWKVNQFDAVI"
     misc_feature    complement(15549..15562)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.34"
                     /tool="antismash"
     gene            15607..16998
                     /gene="yoeA"
                     /locus_tag="CE047_RS15215"
     CDS             15607..16998
                     /codon_start=1
                     /gene="yoeA"
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389719.2"
                     /locus_tag="CE047_RS15215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MATE family efflux transporter"
                     /protein_id="WP_004399508.1"
                     /transl_table=11
                     /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGMM
                     AVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGTTL
                     TFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYTTFL
                     RGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFLVLMV
                     YLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFVNHYGS
                     NATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWLNYIIGG
                     VLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMRASGTVLW
                     PTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQFVWKKKQI
                     TRLIQ"
     misc_feature    17032..17041
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            17132..18109
                     /gene="galM"
                     /locus_tag="CE047_RS15220"
     CDS             17132..18109
                     /EC_number="5.1.3.3"
                     /codon_start=1
                     /gene="galM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389718.1"
                     /locus_tag="CE047_RS15220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldose 1-epimerase"
                     /protein_id="WP_151870209.1"
                     /transl_table=11
                     /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKKTKV
                     QLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHGFL
                     YHENWNVVTAKKTDEEVIVETEIDLSELPHVYKQFPHHAVVRMTYTVKGNTLFKHATVM
                     NKGKEAFPWGIGYHTTFVFPAESSLFSLTADQQWELDERLLPTGKLMDVPNKEALHEGM
                     DLRHKQLDDVFLSSYQKRDGENQAVIYHQHAHISIIYKADEQFNHWVVYNADGKQGYLC
                     PEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ"
     gene            18143..19618
                     /gene="dacB"
                     /locus_tag="CE047_RS15225"
     CDS             18143..19618
                     /EC_number="3.4.16.4"
                     /GO_function="GO:0004175 - endopeptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0009002 - serine-type D-Ala-D-Ala
                     carboxypeptidase activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="dacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389717.1"
                     /locus_tag="CE047_RS15225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="D-alanyl-D-alanine
                     carboxypeptidase/D-alanyl-D-alanine-endopeptidase"
                     /protein_id="WP_151870210.1"
                     /transl_table=11
                     /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSEQIDKILA
                     DHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTE
                     VRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEKLKHSGVKVIKGNLIGDDTWHDD
                     MRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSISPKTD
                     YITIKNGAETTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAGYALDL
                     FKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEM
                     GKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD
                     QSWFSAYLNSLPVAGNPDRMVGGTLRNRMKDTPAQGKVRAKTGSLSTVSSLSGYAETKS
                     GKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ"
     misc_feature    19791..19804
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     gene            20001..>22760
                     /gene="ppsA"
                     /locus_tag="CE047_RS15230"
                     /pseudo=""
     CDS             20001..>22760
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Condensation_Starter (3-300). E-value:
                     4.1e-92. Score: 300.6. Matches aSDomain:
                     nrpspksdomains_CE047_RS15230_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (463-864). E-value:
                     1.8e-111. Score: 364.6. Matches aSDomain:
                     nrpspksdomains_CE047_RS15230_AMP-binding.1"
                     /codon_start=1
                     /gene="ppsA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389716.2"
                     /locus_tag="CE047_RS15230"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="plipastatin non-ribosomal peptide synthetase
                     PpsA"
                     /pseudo=""
                     /sec_met_domain="Condensation (E-value: 6.1e-76, bitscore:
                     251.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-121, bitscore:
                     402.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELHTL
                     EGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQDQA
                     SIPFKLFNSPLYQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKKKDP
                     LPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQSTSAS
                     RDTIILSPDLEQTIRNFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGNRGSKA
                     EKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNELRNEQKD
                     LHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQLNFDYQN
                     TLFSLEDIKRIQSHLLTILENALQHPHSFIRELDMTNTREKQKLLYEFNKTEAVSPKAF
                     TLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASQLAAHLAARGVSNESIVGVLSER
                     SPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSAPNFSGETLE
                     VDMTSLAREKAENHLFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAVSFLTGMQHQFP
                     LSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVKAIHQEKVTTAH
                     FIPAMLNSFLDQAEMLALGDGTNLKRVFAGGEPLAPRTAARFASVLPQVSLIHGYGPTE
                     ATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGELYIAGAGVAR
                     GYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRLDDQVKIRGYRVEPG
                     EIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLP"
     aSDomain        20010..20900
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS15230_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="4.10E-92"
                     /label="CE047_RS15230_Condensation_Starter.1"
                     /locus_tag="CE047_RS15230"
                     /protein_end="300"
                     /protein_start="3"
                     /score="300.6"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIIMDG"
                     /tool="antismash"
                     /translation="HTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELHTLEGA
                     LNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQDQASIP
                     FKLFNSPLYQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKKKDPLPD
                     QPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQSTSASRDT
                     IILSPDLEQTIRNFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGNRGSKAEKE
                     MLGMFVSSLPIRITVD"
     aSModule        20010..22592
                     /domains="nrpspksdomains_CE047_RS15230_Condensation_Starter
                     .1"
                     /domains="nrpspksdomains_CE047_RS15230_AMP-binding.1"
                     /incomplete
                     /locus_tags="CE047_RS15230"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       20079..20195
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS15230_0001"
                     /evalue="2.40E-07"
                     /label="C2_starter_024-063"
                     /locus_tag="CE047_RS15230"
                     /protein_end="65"
                     /protein_start="26"
                     /score="23.4"
                     /tool="antismash"
                     /translation="ICNLTACVKFKGNIELHTLEGALNHSISRNDAIRFQLLE"
     CDS_motif       20400..20465
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS15230_0002"
                     /evalue="9.40E-08"
                     /label="C3_starter_134-155"
                     /locus_tag="CE047_RS15230"
                     /protein_end="155"
                     /protein_start="133"
                     /score="24.9"
                     /tool="antismash"
                     /translation="FHHIIMDGISLNVMGNQIIDLY"
     CDS_motif       20799..20888
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS15230_0003"
                     /evalue="1.20E-08"
                     /label="C5_starter_265-294"
                     /locus_tag="CE047_RS15230"
                     /protein_end="296"
                     /protein_start="266"
                     /score="27.4"
                     /tool="antismash"
                     /translation="DLAIGTYYGNRGSKAEKEMLGMFVSSLPIR"
     CDS_motif       20940..21053
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS15230_0004"
                     /evalue="4.50E-09"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="CE047_RS15230"
                     /protein_end="351"
                     /protein_start="313"
                     /score="28.9"
                     /tool="antismash"
                     /translation="REQLSVMRHQRFPYNLLVNELRNEQKDLHNLIGISMQY"
     aSDomain        21390..22592
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE047_RS15230_AMP-binding.1"
                     /evalue="1.80E-111"
                     /label="CE047_RS15230_AMP-binding.1"
                     /locus_tag="CE047_RS15230"
                     /protein_end="864"
                     /protein_start="463"
                     /score="364.6"
                     /specificity="substrate consensus: Glu"
                     /tool="antismash"
                     /translation="FERQAAFTPERLAIRFSGGSLTYAELDMYASQLAAHLAARGVSNE
                     SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSA
                     PNFSGETLEVDMTSLAREKAENHLFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAVSF
                     LTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVKAI
                     HQEKVTTAHFIPAMLNSFLDQAEMLALGDGTNLKRVFAGGEPLAPRTAARFASVLPQVS
                     LIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGEL
                     YIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRLDDQVK
                     IR"
     CDS_motif       21576..21617
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS15230_0005"
                     /evalue="5.60E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="CE047_RS15230"
                     /protein_end="539"
                     /protein_start="525"
                     /score="19.4"
                     /tool="antismash"
                     /translation="LAVLKAGGAYLPLD"
     CDS_motif       21801..21860
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS15230_0006"
                     /evalue="3.80E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="CE047_RS15230"
                     /protein_end="620"
                     /protein_start="600"
                     /score="34.7"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGQPKGVAVEH"
     CDS_motif       22386..22475
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS15230_0007"
                     /evalue="5.40E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="CE047_RS15230"
                     /protein_end="825"
                     /protein_start="795"
                     /score="57.0"
                     /tool="antismash"
                     /translation="PSGVAGELYIAGAGVARGYLNRPALTEERF"
     CDS_motif       22557..22622
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE047_RS15230_0008"
                     /evalue="7.10E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="CE047_RS15230"
                     /protein_end="874"
                     /protein_start="852"
                     /score="40.3"
                     /tool="antismash"
                     /translation="FLGRLDDQVKIRGYRVEPGEIE"
ORIGIN
        1 aatttttaat agaaacaaac acccggcgca gcagtgtgaa ccgggtgttt tctgcttttc
       61 attatacata tttgtcgaaa agaaacaata caaatcaatg atgaccttca aacttgacat
      121 catttcctca cgtggtaaca ttttaaacgt gtgaaaatgc gaacaaaaaa gcgaacaaag
      181 gagatgttac cgatctttga tcaaaagaaa gtagccttta taggagcagg atctatggcg
      241 gaaggaatga tatcaggtat cgttcgtgcc aacaaaatcc cgaaacaaaa catctgcgtt
      301 acaaaccgca gcaatacaga gcgattaact gaacttgaac ttcaatatgg cattaaaggc
      361 gccttgccga accaactatg tattgaagac atggatgtgc tcattttggc aatgaagcca
      421 aaagacgccg aaaacgctct gtcatcacta aaatcacgta ttcaacccca tcaattaata
      481 ttgtcggtcc ttgccggcat aaccacctct tttattgaac aatcattgct taatgaacag
      541 ccggttgtca gagtgatgcc caacacttcc agtatgattg gcgcttctgc aacagctatt
      601 gcccttggca aatatgtgtc ggaagacctg aagaagctgg ccgaagcatt gctcggatgc
      661 atgggcgaag tctatacaat ccaagaaaat caaatggata tattcaccgg aattgcaggc
      721 agcggacccg cgtattttta ttatttaatg gaattcattg aaaagacagg cgaggaagcg
      781 ggcctcgata aacagttatc tcgaagcatc ggcgcacaga cacttttagg tgccgcaaaa
      841 atgctcatgg aaacaggaga acatcctaag atcttaagag ataatatcac gtcaccgaac
      901 ggaacgacag cagcggggct gcaagccttg aaaaagagcg gcggcggaga agcgatttct
      961 caagcaataa agcatgcggc taagcgttca aaggaaatca gcgaagatat cgaaaaaact
     1021 gcagcgccgc tatcaggagt gataaagtga cgcctgatac aagcatgaaa agagtcgttg
     1081 tgaagattgg aagcagttca ttaacaagcc ttcatggaga aatcagcatt cgaaaattag
     1141 aagcgctggt cgaccagatc gtcaaactca aagacgccgg ttatgaagta attttggttt
     1201 cctcaggcgc agtggcggcg ggatatcgga agctcggatt tatccaaagg cccgagaagc
     1261 ttccagaaaa acaagcatca gcttcaatcg gccagggatt gctgatggag gcttattcaa
     1321 agctgttctt ggcacacggc tatgtcgcat cccaaatttt aattacgaga agcgattttt
     1381 ctgatgaata tcgatacaac aatgtcagga atacaatgaa tgtactgctc gagcgcggca
     1441 tcatcccgat cataaacgaa aatgatacag ttaccgtcaa tcggctcaag tttggcgaca
     1501 atgatacact cgcggcaaaa gtcgcaggat tgattgatgc agatatgctt gtgattttat
     1561 cagatataga cggattatat gacggcaatc cgcgcacaaa tccagaagcg aaaaggatac
     1621 agcgggtgag tgaaataaca cctgacatcg aagcattcgc aggtgacact ggaagcatcg
     1681 ttggcaccgg cggcatgcgc tctaagcttg atgcgtttaa aatcgtaatg gcgtctggca
     1741 ttaaaggttt ccttggtcag gcagatgctg gcgatatttt atatcacgcc gttcatgaac
     1801 aggcggaagg cacctatttt gaagcagaag gaacgcttcc gttgaatcaa aaggagaaat
     1861 ggatcgcttt taattccggt ccggaaggta aaatgttttt atcagatgac tgttcacgaa
     1921 aaataacaaa cggccaatcg agtttatacc tggacggtgt acagaagatt aaagggaaat
     1981 tcaaaagcgg ttcagttgtt cggctgatgg attcaaaagg gacggaaatc ggccttggaa
     2041 tcgtcaatta ctcttctgta cagcttcaag aaccggaaaa gaaaaaggaa ctgacaaaca
     2101 gagctctaat tgatcaagaa gcctttgttt gccatgtgga tttttcttta cctgtaaatt
     2161 aatttgcaga aaaaaacccg aagcttctat atagaagctc gggttcattt ttttattgat
     2221 actgctccag cttagagaaa aattgaatga caaactcata aaaatcattc gcggaaggcg
     2281 caagctctct atttttcggt ttaatgattc cgacagtccg ttttacttga gggaactcaa
     2341 ttggaatttt cacagtaaaa cgaggtgttg tttcagcaaa agtactttca ggcagaaggg
     2401 taacgcccat tcctgcggac actaaccctt tgatagcatc caaatcctca ccctccgtgg
     2461 aaacgagagg agcaaagcct gcttgtttgc aagtatcgat tgccatctct ctaagtacaa
     2521 atccttccgg gaacaataca aattggtcgt tgcgcaaatc gattaaatga accgtttttt
     2581 gtttagcaag cggatgattt aatggaacaa gcgcgtaaat tttttcagta aataatattt
     2641 ttcccgttat gtcagagaaa ttcgtcggca ccggtcctaa taaggccaga tcaatatcgc
     2701 ggtttctgac agcttcaatc agaaacttat aggagccttg gcgcagcaaa aattcgacgt
     2761 gcggatattc ttctttaaac gctgaaatga cagtcggcaa aagctggctg gcgaggcttg
     2821 taggaaagcc gatctttacc gttccgcgat gcgggtcaag atactcatca atttgctctt
     2881 tcgcataatc aatggctttc atcgccgttt tcacatgaat caaaaattct tttccgattg
     2941 gcgtgagttt gatatttctc ccttcacgct caaataaggt cacatttaat tcttcttcaa
     3001 gattggcaat ttgtctgctg attgctgatt gggccacatg caaatgatca gcggcttctg
     3061 aaacgtgttc tctttcagcc acctccatga aataacgcag ttggcgcagc tccatgtttg
     3121 tctcacatcc atctatctca ttttgagatt cttttgatct aaattatata ttgtttatat
     3181 cgttttgaaa acctacaatg attatagagt tgttagattt tatgaccggt atatcggaaa
     3241 ttgatcgggg gagaggaatt atgacgtaca atcaaatgcc aaaagctcaa ggtctctacc
     3301 gtcctgaatt tgaacatgat gcatgcggaa tcggcctata tgcacactta aagggcaagc
     3361 agactcacac cattgtcaaa caaggactta agatgctttg ccagctagac catagaggag
     3421 ggcaaggcag tgatccggat acaggagacg gagccggctt actggttcaa atccctgatg
     3481 ctttctttag aaaagagtgc aaagacatca atctgccaga aaaagaacgt tacggggtag
     3541 gaatggtctt tttctcacag aaagaagatg aaagaaaaaa aattgaaaag caaatcaatg
     3601 cactgattga acaagaaggc caagtcgttc ttggatggag aactgtacct gtaaatgtcg
     3661 gaaaaatcgg aacagtggcg caaaaaagct gtccgtttgt ccgtcaggta tttatcggcg
     3721 caaattctga tctaaaggac aatttatctt ttgaacgaaa attgtatgtc attcgtaaac
     3781 aggctgaaaa ttggggagta acggaaggtc ttgattttta ttttgccagt ctttcaagcc
     3841 agaccattgt ttacaaaggc cttttaacac ctgaacaggt tgatgcattt tattctgatc
     3901 tgcaagacga agcattcgtt tctgcttttg cgcttgttca ttcacgcttc agtaccaata
     3961 cattccctac atgggaaaga gcgcatccta accgctattt ggttcacaac ggtgaaatta
     4021 acacccttcg cggaaatatc aactggatga gagcacgtga gcagcaattt gtttctgaaa
     4081 gcttcggtga ggacttaaac aaaattttgc cgattctcaa tgctgatggc agtgactctt
     4141 ccattttgga taacgcattt gagttttttg tgatggctgg acgcaaaccg gcacatacgg
     4201 caatgatgct cattccagag ccttggacgg aaaatacgca tatgtccaag gaaaaaaggg
     4261 cgttttacga gtaccatagc tccctgatgg agccttggga cggaccgaca gccatttcat
     4321 ttactgacgg taaacaaatc ggggcaatcc ttgaccggaa tggtctccgt ccggcccgtt
     4381 attatgtcac aaaagatgat tatattattt tctcatctga agtaggcgtt attgaagttg
     4441 aacaggagaa cgttttatat aaaaaccgcc ttgagcctgg gaaaatgctt ttaatcgacc
     4501 tggaagaagg ccgtattatc tccgatgagg aagtcaaaac acaaattgca actgagtatc
     4561 cgtaccaaaa atggcttgaa gaagagcttg tacaagtaaa tcctgatccg gagtcaagag
     4621 aagaagaaca atttagtgat cttcttactc gccagaaggc attcggatac acatatgagg
     4681 atatccaaaa gtatctaatt cctgttatta aagaaggcaa agatcccctt ggttcaatgg
     4741 ggaatgacgc tccgcttgct gtactttctg accgagcgca atcactgttt aactacttta
     4801 aacagctgtt tgcacaagta acgaacccgc caatcgacgc gattcgtgag cagcttgtca
     4861 cttcaacgat gacttggctc ggtgcggaag gcgatcttct tcatccaagt gaacgaaatg
     4921 ttcgccggat taaactgtat acacctgttt tatccaatga acagttttac gcattgaaaa
     4981 cgattgttca tcctgattta aaaagccaaa aaattgatgt gctgttttca gaggatcttg
     5041 aacgcggttt aaaggacatg ttcacacaag cagagaaagc catcagccaa ggcgtaagtt
     5101 tgttaatttt atcagacaaa aagatgaacg aacgactgac accaattccg ccgcttctgg
     5161 cagtaagcgc gctgcaccag cacttaatcc gcaaagggct gcgtacgaag gtcagcatta
     5221 ttgtggaatc gggagaagca cgtgaagtgc atcactttgc agcgttaatc ggttatggcg
     5281 cagatgcgat taacccttat ctcgcttatg cgacctacaa gcaggaaatt gatgaaggcc
     5341 gtttggatat cagctatgaa gaagcggtca gcaaatatgg aaaaagcatt actgagggcg
     5401 tcgtaaaagt gatgtccaag atgggaattt caactgtgca aagctacaga ggcgcccaaa
     5461 tctttgaagc ggtaggaatc agccgtgatg tgatcgaccg ctatttcaca ggtactgcat
     5521 cacagctagg cggcatcgat ttacaaacaa ttgcagaaga ggcacagcgc cgccaccggg
     5581 aagcgtatca ggatgattac agcaaaacgc ttgaaccggg aagtgacttc caatggagaa
     5641 atggcggaga gcatcatgcc tttaatccga aaacgattca tactttgcaa tgggcatgcc
     5701 gcagaaatga ttacaatctg tttaaacagt atacaaaagc ggctgatgaa gaacgcatcg
     5761 gatttttgcg gaacttgttc gcatttgacg gaaaccgcaa gcctttgaag ttggaggagg
     5821 ttgaatccgc tgaatcgatt gtcaaacgtt ttaaaacggg tgcgatgtca ttcgggtcct
     5881 tgagtaagga agcgcacgaa gctttagcaa tcgcaatgaa ccgtcttgga ggaaaaagca
     5941 acagcggtga aggcggagaa gatcccaaac gctttgttcc agatgagaac ggcgatgata
     6001 gaagaagtgc gatcaaacaa attgcatccg gacggtttgg tgtcaaaagc cattacctcg
     6061 tcaatgctga tgagctgcag attaaaatgg ctcaaggtgc taagccgggt gaaggcggtc
     6121 agcttcctgg caacaaggta tatccatggg ttgccgaagt ccgcgggtca acgccaggtg
     6181 tcggattaat ctcacctccg ccacaccatg acatttattc gattgaggat ttagcccagc
     6241 tgatccacga tttgaaaaat gccaaccgtg acgcaagaat cagcgtaaag ctggtgtcaa
     6301 aagcaggtgt aggaacaatc gctgcaggtg ttgccaaagc gactgcagat gtcattgtga
     6361 tcagcggcta tgacggaggt acaggcgctt ctccgaaaac cagtattaaa catacagggc
     6421 ttccgtggga gcttggcctt gcagaagcac atcaaacact aatgctgaac ggacttcgtg
     6481 accgtgttgt attagaaaca gacggaaagc tcatgacggg ccgcgacgtt gtgatggctg
     6541 ccttgctcgg cgccgaagaa tttggtttcg caacggctcc gttagttgta ctcggctgtg
     6601 tcatgatgcg tgcctgccat ttggatacat gccctgtcgg tgtagcgaca caaaacccag
     6661 agcttcgcaa aaagttcatg ggggatcctg accatattgt gaactatatg ctgttcattg
     6721 ctgaagaggt tcgtgagtac atggctgcgt taggcttcaa gacatttgat gaaatgatcg
     6781 gccgcactga tgtacttcat gtaagtgaac gggcgaaggg gcactggaaa gcaagccagc
     6841 ttgatttgtc tacacttctt tatcagcctg aaggggtgcg gacgttccga tcgccgcaaa
     6901 atcataaaat tgatcaatcg cttgatatca caacaattct cccggctgta caagaagcca
     6961 tcgaatctgg aaaagaagct gatatttcga ttgaaatcaa taatacaaat cgtgtagccg
     7021 gaacgataac cggcagtgaa atctcaaagc gctacggaga agaagggctt cctgaagata
     7081 caatcaagct gcactttacc ggatcagccg gccaaagctt tggagctttc gttcctaaag
     7141 ggatgacgct ttatttggac ggagactcaa atgattacgt cggaaaaggg ctttctggcg
     7201 gaaaaatcat cgtcaagtca ccagaaggat tcaactctgc ttcggatgac aatgtcatta
     7261 tcggcaacgt ggctttttac ggtgcgacaa gcggagaagc atatattaac ggacgtgctg
     7321 gtgaacgctt tgccgttcga aacagcggtg tgaacgtagt tgtagaaggc attggcgacc
     7381 acggctgtga atacatgact ggcggcagcg ttgtcgttct cggtgatgta ggcaaaaact
     7441 ttgcggcagg tatgtccggc ggaatcgctt atgtactggc cgaagatgtc aaagcgttta
     7501 aacgcaaatg caaccttgag atgattttat ttgaatcatt agaggatgag aaagaaatcc
     7561 agcaaatcaa agcaatgctt gaaagacata ctgcgtatac aaacagccaa aaagcagaag
     7621 atctgcttga tcaatgggaa gacagtgtga aaaaattcgt caaagtcatt ccgaaaaact
     7681 ataaacaaat gctcgcaagc atcgaagagc aaaaagctgc aggtttatca gatgaagaag
     7741 ccatcatgtt cgcttttgag gccaacacga agccaaagca gaatacagca gcttcgggac
     7801 aaaaacaagc ggtagtacag taaggaaggg gagaggaaca tggggaaacc aactggattt
     7861 atggagatca aacgagaaaa acctgcggag cgggaccctc tcactcgctt aaaggattgg
     7921 aaagaatatt ctgctccttt ttcagaagaa gcatcgaaac ggcagggggc gcggtgcatg
     7981 gattgcggta caccgttttg ccagatcggt gcggacatta acggatttac atccggctgt
     8041 ccgatttaca acttaattcc tgaatggaat gatcttgtct accggggcag atggaaggaa
     8101 gcattggaac gcctgttgaa aacaaacaac tttcctgaat tcacagggcg ggtatgtccc
     8161 gctccttgtg aaggatcatg cactttagcg atttcagacc cggccgtttc aattaaaaat
     8221 atcgagcgaa ccattatcga caaaggattt gagaacggct ggattcaacc tagaattcct
     8281 aaaaaacgaa caggcaaaaa agtggccatt gtcgggtcag gcccagccgg actggcgagt
     8341 gctgaccagc tgaatcaagc gggacattcc gtcactgttt ttgaacgagc agacagagcg
     8401 ggcggccttt taacatacgg cattccaaac atgaagcttg agaagggcat tgtagaacgc
     8461 cgaattaaat tgctgacgca agagggaatt gattttgtaa cgaatacaga aatcggtgtt
     8521 gacattacag ctgatgagct aaaggagcaa tttgatgctg tgatcttatg cacaggcgct
     8581 caaaaacagc gggacctctt aattgaagga cgcgactcaa aaggagtcca ttacgcgatg
     8641 gactacctca cacttgcaac aaaaagctat ttagattcta attttaaaga caagcaattc
     8701 attgatgcca aagggaaaga tgtcatcgta atcggaggcg gagatacagg agctgactgt
     8761 gtggctaccg ctctgcgtca aaaagccaaa agtgtgcacc aattcggcaa acacccgaaa
     8821 cttccgccag cccgcacgaa tgacaatatg tggcctgaac agccacacgt ctttacgctt
     8881 gaatatgcat acgaggaagc agaagcaaaa ttcggaagag atccgagaga atactccatt
     8941 caaacgacaa aaatggtcgc ggataaaaac ggaaagctga aagagcttca taccatccaa
     9001 atggaaaaag tgaaaaatga gcatggtaaa tacgagttcc gcgagctgcc tggaacggaa
     9061 aaagtatggc ctgctcagct tgtctttatc gctatcggct ttgaaggcac agaacagccg
     9121 ctgttgaaac agttcggtgt tgattcagta aataacaaaa tcagtgcagc atatggggat
     9181 tatcaaacaa atatcgatgg tgtattcgcc gcaggggatg caagaagagg ccaaagctta
     9241 atcgtatggg cgattaatga aggccgtgaa gtggcgaggg aagtggatcg atatttgatg
     9301 gggagttcag ttcttccgta aataaagggg attatcatat aagagaaacc ggtctggctg
     9361 ccagccggtt tcttttttta ttccattacg atcccgatgt ttccaaactg tctgccttcc
     9421 tgcattcttt tatatgcttc acatgctttt tctaaaggat atatccggtc aattacaggc
     9481 cgcagcttat gtttgtcaat gaaagcgagc atagcttgaa attcctcacc gcttcccatc
     9541 gaggttccca aaacattgac ctgaggaaag aataaagaac gcaccggaaa actgagatta
     9601 tcccctgagc ttgccccaaa gctgacaata cggccatttg gttttacatg gcggaagtat
     9661 tccgaaaaga gggcaggtcc tatgctgtca agaacaacat ctatcttttt tccctgcaac
     9721 tgatcatccc aattgctgta gctgtcaaat gtgtaatcag cacctaattg cagcgccctt
     9781 tttcttttct cctcactgcg ggaggtcacg cttactgttg ccccaatcgc tttagccatc
     9841 aataaagcgt aggttgcaac cccgcttccg atgccgggta tcaatagttg ctcgcctttt
     9901 tttaattgcc cctttgtaaa caaggcccga tatgcagtta aagcggataa aggtaaaacg
     9961 cccgcttctt cccatgataa ataagcaggt tttttgattg cattttgtga aggaatgatc
    10021 acatattcag caagtgttcc gtctgaagga cctcccagaa tctcaggtac aggtggaaca
    10081 ttctctgtca aatcccagtt caatgtcggg aaaatgacta cttctgtctg aacagtaaca
    10141 tttttcacgc cttcaccaat ctcttcaatg atacccgcgc cgtcagaacc gaggatcacg
    10201 tgaggatctt gttcagattt gtttttcata agaaacaagt cacgatgatt cagacccgca
    10261 gatttcaatt taacctttac ctctccgtat ccaggctttg ttgatggaac gtcctgaact
    10321 gataacccca gaagaccggc ttttccgttg tgaattacag ctttcatgct gtctgcctcc
    10381 tcattgaatt gtattctcat atctttacat attttacata gcggttttct tcgagtaaaa
    10441 tgaacaaata tgatagccaa tatcactttt catcatagca agcaggtgag agcgcgtgga
    10501 aagcggagat ttaaagattt ttcaggctgt tgctcgcgaa ggaagcataa cgaaagcagc
    10561 ccaaatgctg aattatgttc agtcgaatgt gacagccaga gtgcataacc ttgaggaaga
    10621 tttgaatatc aggctttttc atcgaacgaa tcgggggatg aagctgactg ctgcaggaga
    10681 aaatcttttg caatatgcag atcaagtatt atcgctgtta gaccaagctg aaaaatcgac
    10741 ccgaatgagc aggcaaccaa aagggccttt gcggatcgga tcactggaaa cgacggcggt
    10801 aacgcatctg cctgagcatg cagcatcctt cctcaggcgt tttcctgaag tggatttatc
    10861 agtgaacaca gctgatacgc atcatttgat tcaacaggtt cttgatcata aagttgatgg
    10921 cgcttttgta tatgggccgg ttgagcacgc tgcagttaga caactccatg tctcccatga
    10981 tgaattagtt ttgatttcat cacgagaagg gacgtcagaa gacatgcttc agcagccgat
    11041 gctctttttt ggggctggct gttctcatcg tgacagggtc aaaagattac tagaggaagc
    11101 aggcatacac aatcaaaaaa tcatagagtt tggcacattg gaggctatta taaaaggtgt
    11161 ttccgccggg atgggtacgg cgctgctccc aaagtccgct gttaactgct ccgagcatcg
    11221 tacaaatgta tggattcatc aattgccacc agcatatcaa gacttagaga tcgtctttat
    11281 atacaggaaa gactttttta ttacgagtgc gtttcagaca tttcttgatg agataaacga
    11341 aatgaaaaga tgaagataga cgtgcattag cagaataaag attttgtcaa agaagcagtc
    11401 atcattctgt cattttggat tgcaatcagg gatacagagc attaccaatg cccgttgtta
    11461 taaagatctg catgaaaaaa ctgtactcat ttgaagcgag tacagttttt taatttattt
    11521 acgttttaaa ttaatgccga tcgccgcgcc gtttctgctt gaatcagcta cgcctttaaa
    11581 ggtgccgttt tcatggtcga tcgatatgct ttgcacgttt ccgatatcca ccggacttgt
    11641 gccgaatttg tggcccatac cgttcagctt gctgaggaca tctttaggaa ctccgtcttc
    11701 gtaacggtaa gagctcatac tgtttgtgta aattctcggc tcttcaacag ctgcttttaa
    11761 ttccatacca tattcaatgt ggtagagaat ggtttgcaaa acggatgaaa taattgtggc
    11821 cccgccagga gatccaacag tgaggacagg cttgtcatcc ttaaataaaa tcgtcggggt
    11881 catgctgctt aaaggccgtt tgtttggctg tacttcgtta gctccgcctg gtatcgcatc
    11941 aaaatccgtt aattcattgt ttaaaataac accgtaatca gggaccataa tacccgttcc
    12001 gaatagctgt tcgattgttg ttgtgtaaga aacaacattt ccccatcgat cagcaactgt
    12061 aaagtgggtt gtttggcctt ctactttgtc tttcggctgt tcaacttgtt tatagtttgc
    12121 tgatccttct tggtatttcc aagggtcacc ggctttcggt tttttattca cttgatctag
    12181 gttgattaat tgctggcgtt ctttaatata atcgggatga agcaggcctt tgagaggaac
    12241 atttacaaat tcgggatcac ctgcgtaaga cgcacggtcg gcatatgaca aatgcatcgt
    12301 ttcagcaagc agctgatatt tttcccatga gcggacatcg tattgtgaaa ggttaaaatc
    12361 atcaaggatt ttcagcattt gcaataagaa aataccgccg gagcttggag gaggagtagt
    12421 agcgatttga tagccttgat agtctcccca aatcggttca tcaatcgtaa tgtcgtaatt
    12481 ttctaaatct ttttctgtca ttgatccgcc gaaatcctgg acagtgtcag aaagcgtctt
    12541 agcgaatttt cctttataaa aagcgtcagt gcctttggag cgaataagct taaatgtttt
    12601 agccaaatcc ttttgaataa gggtatctcc ttctttaagc ggttcgccat ttggtaaaaa
    12661 tacatctttt gcggcagtcc gtgaaagctt ttcctgataa tcagaaatgg cctctgccaa
    12721 caccgaatca atcggaaagc ctttttcagc gagtttaata gaaggggtaa ttaattgctt
    12781 catcgaacgg gttccccatt tatccaaggc ttcttccagc cctttcagag tgcctggaac
    12841 accaacggca gtaccttttg ttacacgttc agagaaagga attgctttgc cgttttcgtc
    12901 cagaaacata tcaggagttg cgcctgctgg agcacgctca cggctgtcga ttatcgttgt
    12961 atccttcgtt tttccgtcat acaccatcat aaaaccgccg ccgccaatac ctgacatcat
    13021 cggctctgtt acattgagtg caaattgaat ggcaaccgct gcgtcaatag catttcctcc
    13081 ttttttcagc acatcagcac cgatttcaga agcaagagga tgtgcggtcg caaccatgcc
    13141 gtcttttcca acatctactt gtttgtactc atcgtagctt ttgggcggtt ttttagcttc
    13201 cgcgtgaaaa gggacacttc cagcgactaa cagaacacta agcagagctg ttaaacagac
    13261 gttccacgtt cttttcatgt tctccctcct atatgaagct gtattgttac aatcttagcg
    13321 taaaaaaatt acagcgtttt cacaagtgac aaatggtata ttatatagta cataaagccg
    13381 tttttctgtg caaaattgat tatattgata tgagccatgt gctatattag aatcagcata
    13441 cggattaaga agggactgct atatgtattt aacgattgaa gaaacagcag aatatacaaa
    13501 tctttcagag gattatatta aaagcttggt gctcgaaggg aaaatcagag ccgttcatga
    13561 cggggagcaa tttttgattt ataaggaaca gttcaaaacg catctcgaac agctggagaa
    13621 ttacaaagca ctggtgcagg aaatattaaa tgaaccgatc ccggaagata ttgatgtaaa
    13681 ggatgaggat taggacacaa tttgaaattg tgtctttttt tgtatatttt tgcggaagct
    13741 ccagaaaatt gggagtgtca gatttcgttt taagaggttt tttgatgatt agtaggggga
    13801 taagtatcca agaggttaaa agctttataa gaggctttaa agcttatttt atagggtgaa
    13861 ggttggaaga agctttttta aaagcttatg taacactatg tatattatgt tacataaacg
    13921 ccgccgcact ttgacattca acgtttttca gctataatag taacatagac ctcaaaacgt
    13981 tacataacgg tttttaagga gttttttgat gcatattgta cagccgattc gcagtctaga
    14041 gaaaatccaa gaagtcaaac agtatttgct taacaaaaac aagcgggatt attttctgtt
    14101 tattttcggc atcaacagcg cgctccgcat ttctgatatt ctgccgctgc aagtgaagga
    14161 cgttcaaaat aaagatcatt tatgggcgac tgaaagcaaa acgaaaaaga aaagaaagat
    14221 tcttatttta gaatcgctga aacaggaaat atacgagtat acaaaagaca tgagggaaaa
    14281 cgaatatctt tttaaatcag tgcggaccag gaagccgatt tcccgcattc aggcctacag
    14341 aattttaaga gaggctgctg cggcgtgcgg acttgaggag atagggacgc atacactccg
    14401 gaaaacgttt ggctatcatt tttatcagcg aacgaaagac atcgccgagc tgcagagaat
    14461 actgaatcat tcatcaccat caattacaat gcggtatatc ggtattgatg aagatacgac
    14521 aagagccgca tataaggttt ttggagggct ttaatacaaa tcgcttgaaa atattgatca
    14581 tcagagctac tatataaata ccaaaagctc tagtagcaca gcggatagtg cagcagtttc
    14641 ctaaactgca ggtcgggagt tcgaatctct cctagagcgt tatattcaca aaaagacaac
    14701 aggcactttt cgcctgttgt ctttctttat gcaaaccaaa taagaaaaac gcccgcttat
    14761 accgggcgtt tttcttatat aactgcgtca aattgattga ctttccattt tttattttct
    14821 ttcacaaatg tcactttccg ttttgcagaa ggggatccgt ctaatgtagg gacggtaaat
    14881 tcgtatgtga ttgtgctgcc ttttttagag atcagtttag cagttgattt tttccaattc
    14941 aaaagattgt ctccgtcacc gattggaaca gcaagttttc cttttgaaac agtgaaatga
    15001 taatctttaa agcctttttc gattgctgtt tttgtaaaaa taggagttaa ataattcacc
    15061 gcttttgctt tagtgcctag atcactgcac atgtatacat attgaagatt ttgatactcg
    15121 aatgtgcctg atggacaaaa tgcttttttc accttcggat tgtggccgct catggtgttc
    15181 caaaaatgtt ctctagcgga taatgccaac tgtaatgctt gtttttgtga taaatcgcct
    15241 gatgtatttt tcgcaaatgc atttgtgctt aatgacagaa taagtgcaat ggttgttaga
    15301 aatagaagac attttttcat tatcgctctc tccttcaaaa tctctttctc ttatgttaca
    15361 aatgttacaa taattacgga tagattacaa tacttttgca taaattattt ttttattctt
    15421 ttactcacaa aaaatacgcc attacttgct agtttattct tcataagcta aaaagatgtg
    15481 taaaattaga agaatcggga agggtttcat atgtgcagtg atgaataata acatgttgca
    15541 tatcctgttt ttgtcaaaaa atgagggcat gtttaaaaac gatttcaaat aaaggagtcc
    15601 tttaatatgg aaacatcaca agaacctctt gtaactcaaa agaaaagcaa accatcagtt
    15661 tggcggtcga tgtcactctt tttagtgccg cttctgctga gcaatgtgct gcaatcagtc
    15721 ggccagctag tcgggatgat ggctgtaggc agatggctcg gtgttgatgc agtggcagct
    15781 gtatcatcct ttttcccatt attttttctt ttaatctcat ttacgattgg gatcggttca
    15841 ggaagttcga ttctgatcgg acaagcttac ggagcgaaaa atgaggaacg gctaaaggct
    15901 gttgtcggga cgacgctcac gtttacattt ttattaggcg ttgtgttagc cgtcatcggc
    15961 agtattttca ccctggatat ccttcgttta atgggcacgc ctgaaaatgt cattcatgtc
    16021 agcgctaact atgcacgtat tttattttat gctatgccgt ttatgttttt atattttgca
    16081 tatactacct ttttgcgcgg aacaggggat tctaagacac cgttttatac gctgattgtg
    16141 agcacggtca tcaacatcgc gcttttgcct gtcttaatcc ttggcatgtt tggttttccg
    16201 aaactgggca tatacggctc ggcatatgca actgtcattt ccacgattgc gacttttctc
    16261 gtgttaatgg tgtatttacg aaagcgaaaa cacccgctgc aatttgataa aacagtgcgt
    16321 cgttatttga aaatggataa ggaactgctg gttctcctgc tgcgtcttgg ggtcccagca
    16381 agcatcaata tgattcttgt ctcattatca gagatagcgg ttatttcatt cgtcaatcat
    16441 tacggctcta atgcaacagc tgcatacgga gtggtcaacc aggtagccag ctatgtacag
    16501 atgccggccg tcagccttgg tattgcggtt tctattttcg ctgcgcaatc gattggggca
    16561 aacgagtttg accgcttaaa gcaggtcatt cgcgtgggga tttggctgaa ttatatcatt
    16621 ggcggcgtac tgatcattct gatctatgtt ttttcacatc agattttatc gttattttta
    16681 accgagcaag agacgcttta cattgcacac cgtcttttga tgattacatt gtggagctat
    16741 ttgctgtttg gaaatgccca aattatttct gcaacgatgc gggcaagcgg aacagtttta
    16801 tggccgaccg tcatcagtat ttttgcaatc tggggagtag aggtgcctgt cgctttcgtc
    16861 ctttctcact atacaaagct tgaaatactc ggcgtctggg ttggttatcc agctgcgttt
    16921 gccgtcagct tgctgttgat ttatgggtat tatcaattcg tctggaaaaa gaaacaaatc
    16981 acacgtctca tccaatagcc tccgaatcac accgttcata agtttgaacg gtgttttttt
    17041 atttgatagg ggaaaatata aaatggagga aatatggcac agtacattga attcttatac
    17101 tagcaatgaa tcaaggagag gttgagtaaa catggcaaac tttattgaga aaatcacgta
    17161 tttgggaacg ccggccatca aagcgggcaa cgaacatcta gaaatgattg ttgtccctga
    17221 gtgggggagc aacgtcattt ctctcgtgga caaaaaaaca aaagtccagc ttttgcgtga
    17281 accggaaaca gcagaaagtt ttcacgacac accaacattg tatggcattc caatcctgtt
    17341 cccgcctaac cgcataagtg acggtacatt cagtttccgg ggcagaacgt atcattttga
    17401 tatcaacgag aaggataaac acaaccatct tcatgggttt ctttaccatg aaaattggaa
    17461 cgtagtgacc gcgaagaaaa ctgatgaaga agtgattgtt gaaacagaaa ttgatctttc
    17521 tgagctcccc catgtgtata agcaatttcc tcaccatgcc gtcgttcgga tgacatacac
    17581 ggtaaagggg aatactctat ttaaacatgc gacggtcatg aacaaaggaa aggaagcgtt
    17641 tccttgggga attggttatc atactacatt tgtgtttccg gcagaaagct cgttattctc
    17701 cctgacagca gatcagcagt gggagttgga tgaacgcctg ctgccgaccg ggaaactgat
    17761 ggatgtaccg aataaagaag ctttgcatga aggaatggat ttgcgccaca agcagctgga
    17821 tgatgtcttt ttatcttctt atcagaagag ggacggagaa aaccaggcag tcatttatca
    17881 tcagcatgca catatcagca ttatttataa ggcagatgaa cagtttaacc attgggttgt
    17941 atacaatgcg gacggaaaac aagggtattt atgccctgaa ccttacacat gggtgacaaa
    18001 cgcagtgaat cttgatttac cttcgtcact cactggttta caagtgctgg agccgggaga
    18061 agaaacgaca gctaaaagca gtatcaccat tgaactgaat catcaatagc caatgatgaa
    18121 gcgcagagag gcggggaaat gaatgaaaaa aagcataaag ctttatgttg ctgttttact
    18181 gcttttcgtc gttgcttcgg tgccttatat gcatcaggct gcgcttgccg ctgaaaaaca
    18241 agatgcactt tccgagcaga tcgataagat tttagctgat catcctgccc tcgaaggcgc
    18301 aatggccggc atcaccgttc gctctgcgga aacaggtgct gttctatatg aacattcagg
    18361 agacacccga atgaggcctg cctcttctct aaagcttttg acagcggccg cggcactttc
    18421 tgtccttggc gagaattatt cttttacaac cgaggtccgg acggatggaa cactgaaagg
    18481 gaaaaagctg aatggtaacc tttatttgaa agggaaaggc gatccgacac ttttaccatc
    18541 tgattttgac aaaatggctg agaaattgaa acattccggc gtaaaagtaa ttaaaggcaa
    18601 tctgatcggt gatgatacgt ggcatgatga catgcgatta tcacctgata tgccttggag
    18661 cgatgaatac acatattatg gcgcgccaat ctccgctcta acagcgtctc cgaatgaaga
    18721 ctatgatgca ggcactgtga ttgttgaggt caccccaaat caaaaagaag gggaagagcc
    18781 tgccgtgtct atctctccga aaaccgatta tataacgata aagaacggtg ctgaaacgac
    18841 tgctgccggt tcagagaaag acctcacaat cgaaagagag catggaacaa acacgattac
    18901 aattgaaggg agcgtaccgg ttgacgcaaa caagacaaag gaatggattt ctgtctggga
    18961 gcctgccgga tatgccttag atttatttaa gcagtcacta aaaaaacaag gtattactgt
    19021 gaaaggggac atcaagacgg gtgaagcacc tagttcttca gatgtgctgc tctctcatcg
    19081 ctcaatgcct ttatcgaaac tttttgtgcc gttcatgaaa ttaagtaata acggacatgc
    19141 cgaagtgctc gtaaaagaga tggggaaagt gaaaaaagga gaagggagct gggaaaaggg
    19201 gctcgaagtg ttaaacagta cgcttccgga atttggtgtt gattctaaat cactcgtctt
    19261 aagagacgga tcaggaatct cacatattga tgctgtatcc tcagatcaac tttcacagct
    19321 gttatatgac attcaggatc agagttggtt ctcggcttat ctaaattctt tacctgttgc
    19381 gggcaatcct gacagaatgg tgggcggaac gctgagaaac cgcatgaaag acactcctgc
    19441 acaaggaaaa gtaagagcaa aaaccggatc gctcagtacg gtaagctctc tatcggggta
    19501 cgcagaaaca aagagcggaa aaaaacttgt tttctctatt cttctaaatg gattgattga
    19561 tgaagaggat ggaaaagata ttgaggatca aatcgctgtc attttggcaa atcaataata
    19621 gcggcagacc tgttttccaa gagaaaacag gtttttttta tgtctgtaat aacgctttgt
    19681 cgaaccttcc aacaattaga agaatcatgc acaaaagaaa attagtccga ttaaaaagta
    19741 gtgtataaga ccttatgtaa aacaatactt ttatcacttt atatccggaa atttgataaa
    19801 aaaagaaacg aaaaataaag aaataatact atattcaaaa aaatgttata aaaatttaat
    19861 gttttttatt gtactttaaa aaatatccgt taatatagtg catatatgga ttatatagtc
    19921 atataatttc ttttattgac atttttctgc ttttttctac tttttcttat cctcttatta
    19981 tgagaactgg agggaatccg ttgagcgaac atacttattc tttaacccat gcccaaagga
    20041 gagtgtggtt tactgaactg ctggagccag ataccagcat ttgcaatctc acagcctgtg
    20101 tgaaattcaa aggcaatatt gagcttcata ctctcgaggg agcgctgaat cattccatct
    20161 cccgcaacga cgccattaga tttcagctgt tagaaggaga agagcttgag ccgcgattgc
    20221 accttactga atataaatat tatccactta gaataattga tttttcaaat gttgaaatga
    20281 tagaaataga gcaatggatt caggatcaag cgagcattcc atttaaactg ttcaactcgc
    20341 ctctttatca attttacctc cttagaattg actctcatga agtttggcta tttgcgaaat
    20401 tccatcatat cataatggat ggaatctctt taaatgtgat gggaaatcaa attatagatc
    20461 tttatcaaaa aatgaaaaag aaagatcctt tacctgatca gccggaacct tcttacttga
    20521 gttacatcga aaaagagagt caatatctac aatctccgcg gtttgcaaag gaccgtttat
    20581 tttggacaca aacctttgag cacccgttgg aataccactc gttagccgac cagacgtcct
    20641 tacaaaaaca gagcacatct gcatccagag acaccatcat tctttcacct gatctagagc
    20701 aaacgattcg aaacttctgc gaagaacaca agatcaatat catttcctta tttatggctt
    20761 cattttacat atgcattagc cgaatcactt ctaaaaaaga tcttgccatt ggcacctact
    20821 atggcaacag agggtcaaag gctgaaaaag aaatgctcgg catgttcgtt agttctcttc
    20881 caatcagaat aacggttgat cctgacacag attttctttc ctttgtccgc acaataggca
    20941 gggaacagct ttctgttatg cgtcatcaac ggtttcctta taatttgctt gtaaatgaat
    21001 taagaaatga acagaaggat ttacacaacc ttatcggtat atctatgcag tatcagccac
    21061 ttcagtggca taatgcagat gattttgact atgaaacagc gctttatttc agcggataca
    21121 ccgcaaacga gctttcagtt caaatacaag aacggataga caatggaacc attcaattaa
    21181 atttcgatta tcaaaatacc ttgttttctc ttgaggatat taaacgaata caatctcatc
    21241 tgcttaccat actggaaaac gcccttcaac atccgcacag ctttataaga gaattagata
    21301 tgacgaatac aagagaaaag caaaaattgt tgtatgagtt taacaagacg gaagctgttt
    21361 cgcctaaagc tttcaccctg catgggctgt ttgagcgaca ggcagctttc acaccggagc
    21421 ggctggccat tcgcttttcc ggcggttcgc tgacatacgc tgagcttgat atgtatgcca
    21481 gccagctggc tgcgcacctt gcggcacgcg gcgtctcaaa cgaaagtatc gtcggtgtcc
    21541 tgtctgaacg ctcacctgac atgctgatcg ctgtccttgc tgtactgaag gccggcgggg
    21601 cgtatttgcc gcttgatcct gcgtatccaa aggagcggct gagctacatg ctgaaagaca
    21661 gcggggcatc gctcttgctg acacagccgg gatgctccgc accgaacttt tctggcgaaa
    21721 cgcttgaagt ggacatgaca tctcttgcga gagaaaaagc agaaaaccat ctgtttactc
    21781 ctgctgacgg cggttctctc gcctatgtca tctatacatc ggggtctacc gggcagccga
    21841 aaggagtggc cgttgagcac cgccaggctg tttcctttct gaccggcatg cagcaccagt
    21901 ttccgctttc agaagatgac attgtcatgg tgaaaacctc tttttccttt gatgcgtctg
    21961 tgtggcagct gttttggtgg gctctttccg gtgcttcggc gtatctgctt ccgcccggct
    22021 gggaaaaaga ctccgcattg atcgtaaaag ccattcatca ggaaaaagtg acaacggctc
    22081 attttattcc ggctatgctg aatagctttc tggatcaagc agaaatgtta gcgcttggtg
    22141 acgggacaaa cctaaagcgt gtattcgccg gaggtgaacc gcttgcgccg cgtacggcag
    22201 cccgttttgc ttctgtattg ccgcaggtat cattaatcca tggctacggg ccgacagaag
    22261 caacggtaga cgcggcattt tacgtattgg atccagaacg ggacagagac cgtttgcgga
    22321 ttccgattgg gaagcccgta cctggtgcgc gtttgtatgt tttagatccc catttagccg
    22381 tacagccttc cggtgtcgcc ggcgaactat acattgccgg agcgggtgtt gccagaggtt
    22441 atttgaatcg gccggcatta acggaggagc gttttctaga agacccgttt tacccgggtg
    22501 aacgtatgta caaaacagga gatgtggcgc gctggctccc tgacgggaat gttgaattcc
    22561 tgggacggtt ggatgatcag gtgaaaattc gcggctaccg ggttgaaccg ggagaaattg
    22621 aagcggcact aagaagtata gaaggtgtaa gggaggcggc cgttaccgta cggacagaca
    22681 gcggcgagcc ggaattatgc gcttatgtag aagggctcca aagaaacgaa gtgcgggcgc
    22741 agcttgagag actgttgccg
//
