LOCUS       NZ_NJRE01000002        21699 bp    DNA     linear   CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain 18-3 18-3_R1_(paired)_contig_2, whole
            genome shotgun sequence.
ACCESSION   NZ_NJRE01000002
VERSION     NZ_NJRE01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 904110)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 904110)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010578165.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:36:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,453
            CDSs (total)                      :: 4,376
            Genes (coding)                    :: 4,252
            CDSs (with protein)               :: 4,252
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 5, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 5, 2 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 124
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 124
            Pseudo Genes (frameshifted)       :: 72 of 124
            Pseudo Genes (incomplete)         :: 64 of 124
            Pseudo Genes (internal stop)      :: 16 of 124
            Pseudo Genes (multiple problems)  :: 23 of 124
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:28:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 800255
            Orig. end                         :: 821954
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NJRE01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21699
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="epipeptide"
                     /region_number="4"
                     /rules="(TIGR04078 and yydH)"
                     /tool="antismash"
     cand_cluster    1..21699
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04078 and yydH)"
                     /kind="single"
                     /product="epipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21699
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11699](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04078 and yydH)"
                     /neighbourhood="10000"
                     /product="epipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11699)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04078 and yydH)"
                     /neighbourhood="10000"
                     /product="epipeptide"
                     /protocluster_number="1"
     misc_feature    complement(12..26)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.46"
                     /tool="antismash"
     gene            201..1547
                     /gene="gntP"
                     /locus_tag="CE047_RS08600"
     CDS             201..1547
                     /codon_start=1
                     /gene="gntP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391887.1"
                     /locus_tag="CE047_RS08600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gluconate permease GntP"
                     /protein_id="WP_077670847.1"
                     /transl_table=11
                     /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFDK
                     VVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVVIA
                     SFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGPTAI
                     AGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQKTFNL
                     EETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAMIISLL
                     VAVYTMGIKRDIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDYVADLFK
                     GTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLATGAGSVI
                     ASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV"
     gene            1570..2976
                     /gene="gnd"
                     /locus_tag="CE047_RS08605"
     CDS             1570..2976
                     /EC_number="1.1.1.44"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="gnd"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391888.1"
                     /locus_tag="CE047_RS08605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="decarboxylating NADP(+)-dependent
                     phosphogluconate dehydrogenase"
                     /protein_id="WP_003243876.1"
                     /transl_table=11
                     /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQKL
                     DGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNSHY
                     EDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAAQVG
                     DDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFETWNQ
                     GELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPSTIITE
                     SLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYAQGFAQY
                     KMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPYFTDKLHA
                     YQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDM
                     DGVFHTNWSE"
     misc_feature    complement(3246..3260)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 23.04"
                     /tool="antismash"
     misc_feature    3380..3395
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            3442..4005
                     /gene="ahpC"
                     /locus_tag="CE047_RS08610"
     CDS             3442..4005
                     /EC_number="1.11.1.26"
                     /GO_function="GO:0102039 - NADH-dependent peroxiredoxin
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ahpC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391889.1"
                     /locus_tag="CE047_RS08610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkyl hydroperoxide reductase subunit C"
                     /protein_id="WP_003243686.1"
                     /transl_table=11
                     /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFSF
                     VCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQTI
                     SRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQNPG
                     EVCPAKWEEGGETLTPSLDLVGKI"
     gene            4019..5548
                     /gene="ahpF"
                     /locus_tag="CE047_RS08615"
     CDS             4019..5548
                     /GO_function="GO:0008785 - alkyl hydroperoxide reductase
                     activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000302 - response to reactive oxygen
                     species [Evidence IEA]"
                     /codon_start=1
                     /gene="ahpF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391890.1"
                     /locus_tag="CE047_RS08615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkyl hydroperoxide reductase subunit F"
                     /protein_id="WP_017697262.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-45, bitscore:
                     151.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDISKDMLALVDELA
                     SMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPKVD
                     QKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKAEVE
                     SKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGADASEFADKEPFDVLVVGGGPAGAS
                     AAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEYDIDVM
                     NLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGVAYCPHC
                     DGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRLYSLPNVT
                     VVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLEGTVERNRM
                     GEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIRN"
     gene            complement(5658..7097)
                     /gene="bglA"
                     /locus_tag="CE047_RS08620"
     CDS             complement(5658..7097)
                     /EC_number="3.2.1.86"
                     /codon_start=1
                     /gene="bglA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391891.1"
                     /locus_tag="CE047_RS08620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-phospho-beta-glucosidase BglA"
                     /protein_id="WP_046381465.1"
                     /transl_table=11
                     /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVPR
                     KITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEPNE
                     AGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEACFTR
                     YKEKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVASALAV
                     AKGKDINPEFQIGAMVSHVPIYPFSSNPKDVMLAEEEMRQRYFFPDVQVRGYYPSYALK
                     EFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGGLPNGVE
                     NPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKVHDPERIQ
                     YLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRDNEGNGSMK
                     RYKKDSFEWYKNVIQTNGEEL"
     gene            complement(7111..7521)
                     /locus_tag="CE047_RS08625"
     CDS             complement(7111..7521)
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014478513.1"
                     /locus_tag="CE047_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="WP_161621094.1"
                     /transl_table=11
                     /translation="MSGKVRDYTRLAKDILEAVGGEENVIGASRCATRLRLVLKRSTPK
                     AKDIVKSMPGVITMVMVAPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT
                     VKKGEVLVEFDKAFIEEIEESALHQKIFTVVS"
     gene            7678..8388
                     /gene="yydK"
                     /locus_tag="CE047_RS08630"
     CDS             7678..8388
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="yydK"
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391893.1"
                     /locus_tag="CE047_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_163136028.1"
                     /transl_table=11
                     /translation="MLKYQQIAAEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTITK
                     SLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVRKP
                     TPEAAENLNIGMDEDIYYVKRVRYINGHTLCYEESYYNKSIVTYLNNEIVSHSIFHYIR
                     EGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKISYNY
                     KQSQFVVQANSFLL"
     gene            complement(8479..9201)
                     /gene="epaB"
                     /locus_tag="CE047_RS08635"
     CDS             complement(8479..9201)
                     /codon_start=1
                     /gene="epaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391894.1"
                     /locus_tag="CE047_RS08635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide ABC transporter permease"
                     /protein_id="WP_014478516.1"
                     /transl_table=11
                     /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPEM
                     FFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFLEC
                     FAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISMLCPNILISIGVSIVY
                     WMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLVSIII
                     INAIILRFSKTRWIKMGI"
     gene            complement(9222..9851)
                     /gene="epeA"
                     /locus_tag="CE047_RS08640"
     CDS             complement(9222..9851)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="epeA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391895.1"
                     /locus_tag="CE047_RS08640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_072173744.1"
                     /transl_table=11
                     /translation="MNIANYTLKVNGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAKD
                     FLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAEMIDKIAHLLNLDN
                     IDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYIQEN
                     PEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE"
     gene            complement(10001..10759)
                     /gene="liaK"
                     /gene_synonym="yydH"
                     /locus_tag="CE047_RS08645"
     CDS             complement(10001..10759)
                     /codon_start=1
                     /gene="liaK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     epipeptide: yydH"
                     /gene_kind="biosynthetic"
                     /gene_synonym="yydH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391896.2"
                     /locus_tag="CE047_RS08645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc metalloprotease LiaK"
                     /protein_id="WP_017697257.1"
                     /sec_met_domain="yydH (E-value: 7.3e-154, bitscore: 508.1,
                     seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDEQLLRF
                     KMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMNIV
                     LHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLFINY
                     FLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEYSRFK
                     TNHWLVLTIQIIGIGLAVNSVVHWILYIVN"
     gene            complement(10740..11699)
                     /gene="epeE"
                     /locus_tag="CE047_RS08650"
     CDS             complement(10740..11699)
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="epeE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     epipeptide: TIGR04078"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391897.1"
                     /locus_tag="CE047_RS08650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YydG family radical SAM peptide epimerase"
                     /protein_id="WP_003242609.1"
                     /sec_met_domain="TIGR04078 (E-value: 1.2e-173, bitscore:
                     572.4, seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.4e-08, bitscore: 30.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.7e-06, bitscore: 23.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.9e-11, bitscore: 40.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTEF
                     AKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFHDM
                     NSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHILEEL
                     GDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGEIYPC
                     CSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKIEEFDI
                     PYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV"
     misc_feature    complement(11683..11701)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 25.45"
                     /tool="antismash"
     gene            complement(11757..11906)
                     /gene="epeX"
                     /locus_tag="CE047_RS08655"
     CDS             complement(11757..11906)
                     /codon_start=1
                     /gene="epeX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614717.1"
                     /locus_tag="CE047_RS08655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="epipeptide YydF family RiPP"
                     /protein_id="WP_014478520.1"
                     /transl_table=11
                     /translation="MKKENTNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWIL
                     GSGH"
     gene            12397..14322
                     /gene="fbp"
                     /locus_tag="CE047_RS08660"
     CDS             12397..14322
                     /codon_start=1
                     /gene="fbp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391899.2"
                     /locus_tag="CE047_RS08660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fructose-1,6-bisphosphatase"
                     /protein_id="WP_044052409.1"
                     /transl_table=11
                     /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLHG
                     EYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAKAA
                     LNEWYKETINRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQYYSE
                     IIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHSVDIQ
                     WGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYYDDNPA
                     FRPKADDNRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKIDYDKNE
                     ITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMNFMMKKGS
                     LYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFAHPEETDDL
                     ATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDEATCRNILAE
                     FGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGIAGYTLLYNSY
                     GMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEELLQEVAILESLR
                     EYRYMK"
     gene            complement(14570..15424)
                     /locus_tag="CE047_RS08665"
     CDS             complement(14570..15424)
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013964.4"
                     /locus_tag="CE047_RS08665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HNH endonuclease signature motif containing
                     protein"
                     /protein_id="WP_095844101.1"
                     /transl_table=11
                     /translation="MALTLEVCSEVLAKCARICCICRLFKPLHVQVHHIREKADGGSDD
                     FDNLIPVCIECHASIHTKTKMTQNFSEKELKKIRDDVYELVSTGYLPKSRSIERKEIEL
                     ISSIFADTLKLSKEDEEKSLSSEALELLSTILCEGKPATFKKVGEDFILFEIGGQYITK
                     KFNEKAQYPGFVIELLAKGLIYTNGNSIEITEEGEQLISTLVQTTATYTQMKVKCLECG
                     LHFIICTWNKDTHNSSTINCPECGQNNENFLVWAQQKFGFIFQDVPGKARLYDVKGLIQ
                     ARE"
     gene            complement(15681..17276)
                     /locus_tag="CE047_RS08670"
     CDS             complement(15681..17276)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012307.4"
                     /locus_tag="CE047_RS08670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA-directed DNA polymerase"
                     /protein_id="WP_163136030.1"
                     /transl_table=11
                     /translation="MEAEIGEEIIEKVVKEFKIKGLFSEYLPSNFNLKSETFDIFKDIE
                     VPNSIDYIEPYKFTMSRFKDNESRRVIHLPEITAYISAVNYMDSEKIIKELIELSAESE
                     NSFSQIVQSNGEILKHETSYGYFEDEGVDESRFIQSTYIPNIAEKIKRAQGGKGILYLD
                     ISNFYGSVYTHIFPAILLGYDKAIEQYKYFQGNKADGRISDIYKRYEKLDGKVRGLNSN
                     RTNGLLTGPLLSFFLAEALLTRIDQEIESAGVSFVRYVDDFEIIIYEDKDIDLYKTIIS
                     DILGKYHFSINNEKTKYVKFPYYVVENLQMIYEEYVSSKAESNDLIKIFNKYFNLENEG
                     NKGAIRYLVKSINERFQVKDYELYVSYLLNILVNDNRSLIKVCELIIKDKDKLTFGDNH
                     IKIIKKLILQYVRHKKDLEVIWLIYLLKNLGVNSIERDIVKNVIRSKNELAIIMIIEEY
                     TEDLDDNIMDELTALSSSWILLYQLFLKNHISTDEFENRVGLNKSKHFYRKLKYNCFTF
                     YKLIADDSRTKFPF"
     gene            complement(17325..17804)
                     /gene="rlmH"
                     /locus_tag="CE047_RS08675"
     CDS             complement(17325..17804)
                     /EC_number="2.1.1.177"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rlmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391903.1"
                     /locus_tag="CE047_RS08675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="WP_163136032.1"
                     /transl_table=11
                     /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAPE
                     NLSDQDMKIIKDKEGERILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSKVT
                     FVIGGSLGLSDAVMKRADEKLSFSRMTFPHQLMRLILVEQIYRAFRINRGEPYHK"
     gene            complement(17885..18055)
                     /gene="yyzF"
                     /locus_tag="CE047_RS08680"
     CDS             complement(17885..18055)
                     /codon_start=1
                     /gene="yyzF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097800.1"
                     /locus_tag="CE047_RS08680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CxxH/CxxC protein"
                     /protein_id="WP_003236479.1"
                     /transl_table=11
                     /translation="MKQTYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACELC
                     GDPAVYIVGNE"
     gene            18239..18653
                     /locus_tag="CE047_RS08685"
                     /pseudo=""
     CDS             18239..18653
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391904.1"
                     /locus_tag="CE047_RS08685"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQLKWVWLFVIMLLLAGCQPSYWVLEKDRIGEGSPDLEIYANYLQ
                     MHDDVKGYQVFTILEGRKMVIVSLGSSEKR"
     gene            complement(18687..19913)
                     /gene="fdhA"
                     /locus_tag="CE047_RS08690"
     CDS             complement(18687..19913)
                     /EC_number="1.2.1.46"
                     /GO_function="GO:0018467 - formaldehyde dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046292 - formaldehyde metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fdhA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391905.1"
                     /locus_tag="CE047_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="formaldehyde dehydrogenase,
                     glutathione-independent"
                     /protein_id="WP_080287639.1"
                     /sec_met_domain="ADH_N (E-value: 1e-25, bitscore: 85.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.2e-11, bitscore:
                     39.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVNR
                     KCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGDIV
                     SVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYADFQL
                     LVFPEKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAHSAQL
                     LGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDCVGFEA
                     SGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIRFGLGWA
                     KAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFDKGAAKKF
                     VIDPHGTLK"
     gene            complement(19976..20146)
                     /locus_tag="CE047_RS08695"
     CDS             complement(19976..20146)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097801.1"
                     /locus_tag="CE047_RS08695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_041850289.1"
                     /transl_table=11
                     /translation="MRTKRVILLAVMICLVSAITVFLLNGCKVDFLDIAGTIIGCFLGI
                     FVVVRIQKKQS"
     gene            complement(20250..20498)
                     /gene="yycQ"
                     /locus_tag="CE047_RS08700"
     CDS             complement(20250..20498)
                     /codon_start=1
                     /gene="yycQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391906.1"
                     /locus_tag="CE047_RS08700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2651 family protein"
                     /protein_id="WP_041850288.1"
                     /transl_table=11
                     /translation="MGAIAVLFIVFGFPIIAGVFGIAGHFLFKRFWVAPLIVLIASLIL
                     LFTLASGNSSFMFWVVMYTAIALVTSIVTLFLRKFFE"
     gene            complement(20514..21677)
                     /locus_tag="CE047_RS08705"
     CDS             complement(20514..21677)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391907.2"
                     /locus_tag="CE047_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_163136034.1"
                     /transl_table=11
                     /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDDK
                     EVLLYFSSSADQDAFGGGKSYALFISQDGSLSSFQMKGLELGSAKVHGDSVMLEDKNTM
                     YTIKDGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKKEGYRSELYRQMDGEWKK
                     DVIPYYIRASGFHDGAIYALVPTADGKGYQLLQIQADQKKLTYHKVTEWQYREGASVES
                     QLAVDDQAVYVMVRGQKAHNLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMPFSFKN
                     SFFPYDGNLYFIDGFGKVHKIDAKTGKTSIAFTLSPDKMKADFKEITQKGSSLYFFTYT
                     YHKPAYIEQYNLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF"
ORIGIN
        1 tttcgacgcc gtgtccgaca tgatcggcag cacatacaga catacgccga tcgaagactc
       61 agccaaggaa tacagaacat taatgccgat tttcatcaat ctatcaagat tattagaaaa
      121 tcaatataca caaattgcag attatcagag gggcttaatc acacacaaat agtacatgac
      181 atgaagggga gggcattacc atgccgttaa tcatcgttgc acttgggatc ttagcattac
      241 tatttctgat tatgggctta aaattaaaca catttatttc cctgctggtc gtatcgttcg
      301 gcgtggcact ggcactcggg atgccgttcg ataaggttgt cagctccatc gaagcaggga
      361 taggggggac tcttggccac atcgcgctca tcttcggact cggtgcgatg ctgggcaagc
      421 tgatcgcgga ttcaggaggc gcacagcgca ttgcgatgac gctcgtcaac aaattcggcg
      481 agaaaaatat tcaatgggcc gttgtcattg cctcatttat tattgggatt gcgttatttt
      541 ttgaagtagg actggttcta ttaattccga ttgtctttgc gatttcaaga gaattgaaga
      601 tttctatttt atttctcgga atcccgatgg tcgcggcact atccgtcaca cacggtttcc
      661 tgccgccgca cccgggacct acggcgatcg ccggtgagta tggcgcaaac attggagaag
      721 tgctgctgta cggctttatt gttgctgttc cgacagtgct catcgcaggg ccgttattta
      781 caaagttcgc gaaaaaaatc gttcctgcat catttgcgaa aaacggcaat attgcatcac
      841 tcggcacaca aaaaacgttt aaccttgaag aaacacccgg ctttggaatc agtgtcttta
      901 ctgcaatgct cccgattatc atcatgtcgg tcgcgactat tatcgacctg cttcaagaaa
      961 caatcgggtt tgcagataac ggagttttag cttttatcag attgattgga aacgcatcga
     1021 ctgctatgat tatttcgtta ttggtcgcag tctatacaat gggcatcaag cgcgacattc
     1081 cagtcaaaac cgtgatggat tcttgttcaa ctgccatttc acaaatcggc atgatgcttt
     1141 tgatcatcgg aggaggcggc gccttcaaac aagtgctgat caacggcggt gtcggcgatt
     1201 acgtagcaga cctattcaaa ggaacggcat tatcgccaat cattctggca tggctcatcg
     1261 cagcgatcct gcgcatttct ctaggatcag cgactgttgc cgcactaagc acaacaggtc
     1321 tggtcattcc gttattgggc cattctgatg ttaacctggc gttagtcgtg ctcgcaacag
     1381 gcgccggaag tgtcatcgct tcacacgtca atgacgccgg cttctggatg ttcaaggaat
     1441 acttcggatt aagcatgaaa gaaacattcg ccacatggac attgctggaa accattattt
     1501 ccgttgctgg actgggattc attttattgt taagtttagt tgtatgaaat taagaaggag
     1561 ctgtaacaca tgttcaattc gattggtgtc ataggcttag gcgtaatggg aagcaacatc
     1621 gccttaaaca tggcaaataa aggcgaaaac gtcgctgtct ataattacac cagagattta
     1681 acggaccagc ttatccaaaa gctggatgga caatctctca gcccgtatta cgagcttgag
     1741 gactttgttc aatcgttaga aaaaccaaga aaaatctttt tgatggtcac agcgggaaaa
     1801 cccgtagatt ccgtcatcca atcattaaag cctttgcttg aagaaggcga cgtcatcatg
     1861 gacggaggaa actcccacta tgaagacaca gaaagaagat atgacgagct gaaggaaaaa
     1921 gggatcggct acctgggagt cggcatttcc ggcggtgaag tcggtgcgtt aacagggcct
     1981 tccatcatgc cgggcggaga tcgcgacgtc tatgagaaag ccgctcctat cctgacgaaa
     2041 atcgcagccc aagtcggaga tgacccttgc tgtgtctata tcggaccaaa aggggcaggg
     2101 cactttacaa aaatggtgca caacggcatt gaatatgccg acatgcagct gattgcagaa
     2161 gcttatacgt ttctaagaga aacgcttcgt ctgccgctag atgaaattgc atctattttt
     2221 gaaacatgga atcaaggtga gctgaaaagc tatttaatag agattacagc tgagatttta
     2281 cgcaaaaaag acgaaaaaac aggacagcct ctgatcgatg tcatccttga taaaaccggc
     2341 caaaaaggca ccggaaaatg gacgagcatg caggcgattg ataacggcat cccgtccacg
     2401 atcatcacag agtccttgtt cgcccgctac ttgtcatctt taaaagaaga acggatggca
     2461 gctcaagatg tattagcagg cccggaagcc gaagaaaaac acttggataa agacacttgg
     2521 attgaatacg tcagacaggc tctttacatg gggaaagtat gcgcctatgc acaaggcttt
     2581 gcccaatata agatgtcatc tgagctttac ggctggaatc tgccgctcaa agacatcgcc
     2641 ttgattttcc gaggcggctg catcatccgc gctgatttcc taaacgtgat cagcgaagca
     2701 ttcagtgagc agccaaatct ggctaacctg ctgatcgcgc cttatttcac agataagctc
     2761 catgcctatc aaacaggcct gcgaaaagtc gtttgcgagg gtatcagcac cggaatctct
     2821 ttcccatgct taactaccgc gctctcttat tacgacggct accgcacagg gcgttccaat
     2881 gcgaacctct tgcaggcaca gcgcgattac tttggcgctc acacgtacga acggactgat
     2941 atggacggcg tcttccatac gaattggtct gaataacctg tcatcaaaaa cacggtcagt
     3001 tttcaactga accgtgtttt tttcttctat cccaaacaac agaagacata agttatgttt
     3061 taaatatcat aaacagtgat acaataatag ctagaaacaa tccccaagat catcatgtga
     3121 cagcagcttg ctgttccgtt ctattctgct tttggccatt gtcctttgcc cttgcccatg
     3181 gtgtcataaa atgttcaaat gccaaaacgg cctgtcattc tgatttacaa aagtccctga
     3241 aaaccttgtc taattgagaa tcaggctctc atttgttata aaagaaatgc ctaaatccta
     3301 cctgtcacac ctttagtaag atgaaaaaaa gtaggttatg gcttgacaaa aaatatatat
     3361 taattaataa ttcatatata attagaatta ttattgaaag cgaatatgct ttctaataca
     3421 tttttaggag gaatatacat tatgtcttta atcggtaaag aagtacttcc attcgaagca
     3481 aaagcattca aaaacggtga attcatcgat gtaacaaacg aagatttgaa aggccaatgg
     3541 agcgtattct gcttctaccc agcagatttc tctttcgtat gcccaactga gcttgaagat
     3601 cttcaagaac aatatgctgc acttaaagaa ttaggtgttg aagtatactc tgtttctaca
     3661 gatactcact tcgtacacaa aggctggcat gacagctctg aaaaaatcag caaaatcact
     3721 tacgcaatga tcggtgaccc atctcaaaca atctctcgca acttcgatgt tcttgacgaa
     3781 gaaactggtc ttgctgaccg cggaacattc atcatcgatc cagacggcgt catccaaact
     3841 gtagaaatca atgcaggcgg tatcggccgt gacgcaagca accttgtaaa caaagtaaaa
     3901 gcagctcaat acgttcgtca aaacccaggt gaagtttgcc cagcgaaatg ggaagaaggc
     3961 ggcgaaactc ttacacctag ccttgatcta gtaggtaaaa tctaaggagt gcattcaatt
     4021 ggtacttgat gcaaatatca aagcacaatt aaatcaatat atgcagctaa ttgagaatga
     4081 cattgttctc aaagttagcg caggcgaaga tgacatttca aaggacatgc tggctctcgt
     4141 tgatgagctg gcttccatgt catcgaaaat ttcagttgaa aaagctgaat taaacagaac
     4201 gccaagcttc agtgtcaatc gtgtcggaga agacactggc gtgactttcg ccggtatccc
     4261 tctgggccac gaattcacat cattagtgct ggcgttgctc caagtgagcg gcagaccgcc
     4321 taaggtagac caaaaagtca ttgatcaggt gaagaagatc agcggtgaat accactttga
     4381 atcttatatc agcctgacat gccacaactg tcctgatgtt gtacaggctt taaacatgat
     4441 gagcgtgctg aatccgaaca ttacgcacac gatgattgac ggtgcagcat acaaagcaga
     4501 agttgaaagc aaaaacatca tggcagttcc gaccgtttac ctgaatggcg aatccttcgg
     4561 aagcggccgc atgacgcttg aagaaattct tgcgaaaatg ggcagcggcg cagatgcatc
     4621 tgagtttgct gacaaagagc cgtttgacgt tcttgttgtc ggaggcggac ctgctggtgc
     4681 aagtgcagcg atctacactg cacgtaaagg catccgcact ggggttgtcg ctgaacgctt
     4741 cggcggacag gttctcgaca ccatgagcat cgaaaacttc atcagcgtca aagcgacgga
     4801 aggaccgaag cttgcggcaa gtcttgaaga gcatgtgaag gaatatgata ttgatgtcat
     4861 gaaccttcag cgtgcgaaac gccttgagaa gaaagatctg ttcgaacttg aactcgaaaa
     4921 cggcgctgtt ctgaaaagta aaacagtgat cctttcaaca ggtgcacgct ggcgcaatgt
     4981 caacgtacca ggtgaacaag agttcaaaaa caaaggtgtc gcatactgcc cgcactgtga
     5041 tgggccattg tttgaaggca aagacgtagc ggtaatcggc ggcggaaact ctggtattga
     5101 agcagcgatt gaccttgcag gtattgtcaa tcatgttact gtgctagagt tcgcaccgga
     5161 actgaaagca gacgaagtcc tgcaaaaacg tctctacagc ctgcctaacg ttactgttgt
     5221 aaaaaacgca caaacaaaag aaatcacagg cgatcagagc gttaacggca tcacatacgt
     5281 agaccgcgaa acaggcgaag aaaaacacgt tgaacttcaa ggtgtattcg tccaaatcgg
     5341 tctcgtgcca aacacagaat ggttagaagg aacggttgaa cgcaaccgca tgggcgaaat
     5401 cattgtcgac aaacacggcg caacaagcgt accaggctta tttgctgccg gcgactgcac
     5461 agacagtgcg tacaaccaaa ttattatttc tatgggatca ggtgcaactg ccgccctcgg
     5521 cgcgtttgat tacctaatcc gtaactaata taagaaatcc gctatattgc cagattggca
     5581 ggatagcgga tttttctttt tctacagaaa aaaaccgaac caggcactac ggtaaaagtg
     5641 ctcgattcga gcgcttctta tagttcctca ccattcgttt gaatgacatt tttataccac
     5701 tcaaaggagt ctttcttata tcgtttcatg gatccgtttc cttcattgtc acgatcaaca
     5761 tagatcatgc cgtagcgttt tttcatttcg ccagttgtga aggagacaat atcaataatg
     5821 ccccacggcg tgtagccaat taaatcaaca ccatcgtacg tgaccgcttt tttcaatgct
     5881 tcaatatgcg attttaaata ttgaatgcgt tccggatcat gaaccttgcc gtcctcctcc
     5941 agcgtatcca ctgcgccaaa gccattttca acgatgaata acgggatttg gtatcggtca
     6001 taaaaacgat ttaacgtata tctcaacccg gttggatcaa tcgcccatcc ccagtcactc
     6061 gaagtgatgt acggattttc gacaccattc ggcaagccgc catttacaat atcgccagtg
     6121 ttatcatttt tcacatcgct tttcacagtt gttgacatgt aatagctgaa gcctaagtaa
     6181 tcgacggttc cgtttcttaa aatctcatca tcgccgtctt cgaatgtgat gttgtagcct
     6241 tcgcgttcaa attccttcaa cgcgtagctt ggataataac cgcgaacctg cacatcaggg
     6301 aagaaatagc gctgcctcat ttcttcttca gccagcatca catctttagg attggaggag
     6361 aaaggataaa tcggcacgtg tgataccatg gccccgatct ggaactctgg attgatgtct
     6421 tttccttttg ccactgctaa tgcgctcgcc actaattcgt ggtgcgccgt ttgatacatg
     6481 acttccttgg cgttttcgtt ttcgccaact acaacacctg aattcgtcca taggaacagc
     6541 ggattgttca catccatttg gttgttgatc tcgttaaatg tcatccagta cttcactttc
     6601 tctttgtaac gggtaaagca agcctctgca aagttgacga agaagtccac gactttccgg
     6661 tttctgaagc cgccatattc tcttgccagg tgcagcggca tttcaaagtg agacagcgta
     6721 atgaccggct cgatcccatg cttcagcaat tcatcaaaca catcatcata aaactgcaaa
     6781 ccagcttcgt tcggttcagc ctcatcgcct ttcggaaaaa tccggctcca gccgatggac
     6841 gtccgcagac attttaatcc catttctgca aacaaagcga tatcttcctt gtatctgtga
     6901 tagaaatcaa tggcttcatg gttcggataa aactcgttct cttcaatcgt atccgtgatt
     6961 tttctcggca cgccgtgtgc acccgctgtc atcacatcga cgacactcgg ccctttacct
     7021 ccttgattcc atccgccttc aaattggtgg gcagctaaag caccgcccca taaaaaatcc
     7081 ttcggcatgt ttcccatgtt taattcctcc tcagcttacg actgtaaata ttttttgatg
     7141 caatgcactt tcctcaatct cttcaatgaa agctttatca aactcaacaa gcacttcgcc
     7201 ttttttgacg gtatcgcctt cttttacctt caaggaaaaa ggcgtgccgt caaatgtcac
     7261 cgtatccagc ccgatgtgcg caagcaattc gacgccagac gctgaacgca ggccaatcgc
     7321 atgctttgta ggcgcgacca tgaccatcgt aatgacgccg ggcatcgatt tcacgatatc
     7381 cttcgcttta ggggtagacc gcttcagcac caatcgaagt ctggtagcgc agcgagaagc
     7441 ccctatcaca ttctcttccc cgcctacggc ctctaaaatg tcttttgcta gtctcgtata
     7501 atctctcact ttccccgaca ttttcaccca cccctttgtt tggttacgct ttcattataa
     7561 ttgtaccgat ataattcatc aatgccgaaa caaaatattt acgcactaac tataattgta
     7621 agcggtttat gctataattt tgacaagtga aactaaacga ataaatgagg aatgcgtatg
     7681 ttaaaatacc agcaaatcgc agcggaaatt gaaacatata tagaagaaca ccagcttcag
     7741 cagggagaca aactgccagt cctagaaacc ctcatggccc agtttgaagt cagcaaaagc
     7801 accatcacaa agtccctcga gctattagag caaaaaggcg cgatctttca ggtcagagga
     7861 agcggcattt tcgtcagaaa acataaacga aaaggctata tcagccttct gtcgaatcag
     7921 ggatttaaaa aagacctcga ggattttaac gtcacctcaa aagtcatcga actggacgtg
     7981 agaaagccaa caccggaagc ggcggaaaac ctgaacatcg gaatggacga ggacatctac
     8041 tatgtcaaaa gggtccgcta catcaacggc cacacccttt gctacgaaga atcctattac
     8101 aacaaatcga tcgtgacgta tttaaacaac gaaatcgtct cccactccat cttccattac
     8161 atccgggaag gactggggtt gaagattggt ttttctgatt tgtttctgca cgtgggccag
     8221 cttaatgagg aggaagcgga atatttggga ttagaggctg gactgcctaa gttgtatata
     8281 gaaagtattt ttcacctgac aaatgggcag ccgtttgatt actcgaagat ttcgtataat
     8341 tataagcagt cgcagtttgt ggtacaggct aatagttttt tattgtgaaa ttcggtatct
     8401 aataggattt cttttaataa ttctccacca aatattatgt tcaaaaaaag ctacttcact
     8461 gtgaagtagc ttcctttatt aaatgcccat tttgatccat ctagttttag aaaagcgaag
     8521 gataatcgca tttatgataa taattgaaac taaatacaaa ataataaata aaacatcatt
     8581 actcccaagt gtcatgttat cagattgcag cactctttct attcggggat acatagtgtt
     8641 acctgcctca aaaggagcaa tgaaaccaaa cgttttattg cttatagcta ctaagataac
     8701 agaagtcatc caataaacga tactgacacc tatactaatt aatatattag gacataacat
     8761 gcttatagtt ccaataatta gaatatactg cagtataact gcagaaaata aaaaaagtaa
     8821 taatgcaaaa tgcgaaaaat catggtacat caacgatatg attagcaggc ctagcgttat
     8881 aaatgcaaaa cattctaaaa ataaaacagc tatcttttta taaaagaaag tatagatgtt
     8941 ctctccaatt aatttgtaaa agagaatatt tttgtttgaa tactctctat taataaagaa
     9001 agctataaca aatgaaaata acatcaaacc aaactgggtc gcaacagtat aggagctaaa
     9061 gaaaaacatt tcaggtgtaa cattgctgac tttatcaatt ccaacaagta aaaaataacc
     9121 cagcaagaat aaaaatacaa acattgctcc taaaataatg ataactttgt tgctaatact
     9181 ctttttaaac tctaatttca tctcaagccc ccactgtttt attactcgtt tatatacact
     9241 tcaattaatt tatccactga atgatattgt tgaatttctt ggtgattaaa tatataataa
     9301 tccccttcta tcgcctttaa atcagacaaa tcatgtgtaa tgttgatgat aatcttctcg
     9361 gggttctcct gaatatactt gtttaagaag ccatgaatct ctataaccgt ttttttgtct
     9421 aatgaattcg ttatttcatc taaaacaata atatttttat cctctaataa gaaactgagc
     9481 aattttaatt tttgcttttg tccatcactc aaatttttga tcagaacttt tccatcaata
     9541 ttatccagat taagtaaatg tgcgatttta tctatcattt ctgcatcaaa ttttttactc
     9601 aaaaagtgta ataaaaagtc cttagaaaca tcattaggta tattcgaaga gctggatatt
     9661 aaagaaacat tttgacgaat atctctgccg attcttttgc tattattcaa caaaaagtct
     9721 ttagcaagct gtgatttacc gactccattt tttccgacaa cgtgattaat tttcccgctc
     9781 gaaaaatgca agtcggtgtc ctgaagtaac gttttgccat tcacttttaa agtgtaattc
     9841 gctatattca tatacatact cctaggaaat atttgcataa taataaaatg ttctgccttg
     9901 tgatttgtta ctaatgtcta agcttttgag gtacctcttt cgtttccgat ctggaagcgc
     9961 aagaaatgtt tttagatggc taatttggag atcttttact ctagtttaca atatataata
    10021 tccaatgtac aactgaattc actgcaaggc caatccctat aatttgaatc gtaagaacta
    10081 accaatgatt tgtcttaaaa cggctatatt catctaagct cagaaaagct aaaagaattt
    10141 tgtaaccatc agaattcagt attggaatta agttccacaa taaagtagac gagaaaagca
    10201 taaatgccat agttaatgct tcactggaaa atgtaaattg atttattaat tctaatgtgt
    10261 ttattaaaaa ataattgata aacaagccaa ataaatgaac gattatcttt tcatttcttg
    10321 atagcatata ggtttcattc aattggacat aaaaagcagg aaatacataa aaattcagtt
    10381 tgaatcccac tttatcaaag tttttcccga aaaattttaa ggaataaata tgtcccagtt
    10441 catgaagcac tatattcatt ataaagtaaa taactataat tatccacatt ttccagccat
    10501 aaaatactga ggacaatcca ttttgcaatt ttattaaatg aatataattt aatatgaaca
    10561 tgagagccgt aaaggataag aacagataaa aaaactttgg tgatactttc tctttataca
    10621 ttttaaaacg taataattgt tcatctgaca gagaatttaa actattttta tagtattctc
    10681 cgcttttttt gtcttttata aatacgttgt tttgcacaag cacttcatat ttttcatctt
    10741 catactttaa aattttcatt atagtatttt tccatataag gatagaagta gtttattttt
    10801 tctgcagagt tgaataagga accacaaact ccacaaatag aggaaaattc ataaggaatg
    10861 tcaaattcct ctatcttgtt attctctttt aaaatattca aaaaccattt gaatccttct
    10921 tttctaagaa taaataatag caaattggaa tttaactttt ccacggttct ttcgaaactt
    10981 tggttatatt cttcccttag ggttattttc gtttcaaaaa tagcagggga acaacatgga
    11041 taaatttctc catcatgatg atatacaatg tcatatccgg gacaatgtaa ggaatcttca
    11101 tcttcaagac tgtaaaattt atgtatgttt tcttgcttaa ttctagtttt agcagcgcca
    11161 actgatatca ttggaaattt tgttatcttt acacctaaga ttgaatcccc caattcctct
    11221 aaaatatggt tggacatttt gtctttggta actgccatat taagagaaat atcgatatca
    11281 gggtatttcc tgctatgttc taatatgttt ttaatactgg aagacttgac aaatggagca
    11341 tggtactcat cataacttat agtcagtgct atcacattta aagaattcat atcatgaaag
    11401 tactcctgga cctttttctt gctcaaaccc caaaatccat tagagatcaa cgttatttgt
    11461 ttttcatatg gtttaatgat ttccattagt tcttttaaaa atttataatc taaaaaaact
    11521 tccccacctg taaaagaaat cacttgaatg gttttgtttt ttgcaaattc agttactaac
    11581 tctcttatgt attctttttc catcctggtt gttgaagttg gtgaactaga aaaacaacaa
    11641 tggtcacagg atgcattaca ccttgaatct aaattgattg atactgtttt attatacatg
    11701 aaatatcccc caacaaatgg taaaggagag ttagactctc ctttgtaccc ctctaattaa
    11761 tgaccacttc caagaatcca gcgattttct tttgatttta caaaatacca aagatcattc
    11821 acttttgcta acttttgtga ttcatctaat agacccttaa attctaagtt tttcacagtc
    11881 tcattgttag tgttttcctt tttcatatta tccctccttc ttttctaata taaaccaatt
    11941 attctatatg attcaataca tgtcaatata ttgtacctaa aaaatctgaa aaatgtcact
    12001 attcttagta tataaagcct atagtcctct agcccctcta agctataccg aatgaaaggc
    12061 catagtttga tttaaagctt cgtaatgaaa agtaaaacat caatattgac tacactagtt
    12121 aagggatata cagattttaa gtggaagaaa tgaggcaaac aatcttaccc caaaccaacc
    12181 tgcaagatcc tctatggata ctactgaaaa gctgttttaa gctcttgctt accccatttg
    12241 gcatctcttt ctctcgtttc aattgtcata aaaagcagtt atgcggtact atcatataaa
    12301 ggtccaataa tgaaaaccaa tgtcatactt ttaaattcac cttatcatgc acatgatcat
    12361 atataggggt ttattctaaa aaggggatgg acgattttgg aaagcaagta cctagatcta
    12421 ctcgcgcaaa aatacgattg tgaagaaaaa gtggtaacag aaatcattaa tttgaaagcg
    12481 atattgaacc tgccgaaggg cactgagcat tttgtcagtg atttgcacgg ggagtatcag
    12541 gcattccagc acgtgctgcg caatggttca ggacgagtca aagagaagat acgcgacatc
    12601 ttcagcggtg tcatttacga tagagaaatc gatgaattag cagcattggt ctattatcca
    12661 gaagacaaac tgaagttgat caaacatgac tttgatgcga aagcagcatt aaacgagtgg
    12721 tataaagaaa ccattaaccg aatgattaag ctcgtttctt attgctcctc caagtatacc
    12781 cgctccaaac tgcgcaaagc actgcctgcc cagtttgctt atattacgga ggagctgtta
    12841 tacaaaacag aacaagctgg caacaaggag caatattact ccgaaatcat tgatcagatc
    12901 attgagcttg gccaagccga taagctgatc accggccttg catacagcgt tcagcgattg
    12961 gtggtcgacc atctgcatgt ggtcggcgat atttacgacc gcggaccgca accggatagg
    13021 attatggaag aactgatcaa ctatcattct gtcgatattc agtggggaaa tcacgatgtc
    13081 ctttggatcg gcgcctattc cggttccaaa gtgtgcctgg ccaatattat ccgcatctgt
    13141 gcccgctacg acaacctgga tattattgag gacgtgtacg gcatcaacct gagaccgctt
    13201 ctgaacctgg ccgaaaaata ttatgatgat aatccagcgt tccgtccaaa agcagacgac
    13261 aacagaccag aggatgagat taagcaaatc acaaaaatcc atcaagcgat tgccatgatc
    13321 caattcaagc ttgagagccc gattatcaag agacggccga actttaatat ggaagagcgg
    13381 ctgttattag agaaaataga ttatgacaaa aatgaaatca cgctgaacgg taaaacatat
    13441 caactggaaa acacctgctt tgcgacgatt aatccggagc agccagatca gcttttagaa
    13501 gaagaagcag aagtcataga caagctgcta ttctctgtcc agcattccga aaagctgggc
    13561 cgccatatga attttatgat gaaaaaaggc agcctttatt taaaatataa cggcaacctg
    13621 ctaattcacg gctgtattcc tgtcgatgaa aacggcaata tggaaacgat gatgattgag
    13681 gataaaccgt atgcgggccg tgagctgctc gatgtatttg aacgattctt gcgggaagcg
    13741 tttgcccacc cggaagaaac cgatgacctg gcgacagata tggcttggta tttatggaca
    13801 ggagagtatt cctccctctt cggaaaacgt gccatgacga catttgagcg gtatttcatc
    13861 aaagagaagg aaacgcataa agaaaagaaa aatccgtatt attatttacg cgaagacgag
    13921 gcaacctgcc gaaacatcct ggcagaattc ggcctcaatc cagatcacgg ccatatcatc
    13981 aacggccata cacccgtaaa agagatcgaa ggagaagacc caatcaaagc aaacggaaaa
    14041 atgatcgtca tcgacggcgg cttctccaaa gcttaccaat ccacaacagg catcgccggc
    14101 tacacgttgc tatacaactc ctacggcatg cagctcgtcg cccataaaca cttcaactcc
    14161 aaggcagaag tcctaagcac cggaaccgac gtcttgacgg tgaagcgatt agtggacaaa
    14221 gagcttgagc ggaagaaagt aaaggaaacg aatgtcggtg aggaattgct gcaggaagtt
    14281 gcgattttgg agagtttgcg ggaatatcgg tatatgaagt gagggatgtg ggctcagaga
    14341 ggactttctc tgagctctat ttacgttttc cactaagtac agcaaattgc taacaaagtc
    14401 tggttttatg cttgtttgat agtatttcaa tacaaataca gagagcgtta tttgcgcaaa
    14461 aacaaaaaaa ctatacagaa ttaattagtg tagagagtag tgattatcaa gtgttcttaa
    14521 attagttatt tattataaat aaatttcaat taaaccttga aatatacctt tattctcttg
    14581 cttgaatcaa tcccttgaca tcataaagtc tagctttccc aggaacatct tgaaatataa
    14641 aaccgaattt ttgttgagcc catacaagaa aattctcatt attctgtcca cattcaggac
    14701 aattaatagt agaactatta tgtgtatctt tattccaagt acaaataata aagtgtaatc
    14761 cgcattctaa acattttact ttcatttgag tgtaagttgc tgtagtttga actaatgtac
    14821 taattagctg ttcaccttcc tcagtgattt cgattgaatt tccattcgta taaattaggc
    14881 ctttagcaag taactctata acaaatccag ggtactgtgc tttttcatta aattttttag
    14941 taatatattg tccgccaatt tcaaacaata taaaatcctc tcccactttt ttaaaagttg
    15001 ctggtttccc ttcacataga atggtggaga gtaattctag cgcttcacta ctcaaagact
    15061 tctcttcatc ttctttactg agtttgagcg tatcagcgaa tatagatgat attaattcaa
    15121 tttcttttct ctctattgat ctgctttttg gaaggtaacc tgtgctcacc aattcataaa
    15181 catcatctcg aatcttttta agttcttttt cagaaaaatt ttgagtcatt tttgtttttg
    15241 tatgaatact agcgtgacac tcaatacaga caggtattaa attatcgaaa tcatctgatc
    15301 ctccatcagc cttttcccgt atatgatgca cctgaacatg tagtggttta aatagtctac
    15361 aaatgcaaca aattcttgca cacttagcca gaacttccga acacacttcc aaagttaatg
    15421 ccacttttaa ctactcctct cataaattct tttgctttct ttttaactca tgtattctat
    15481 tttgttttga aagaaagttc tatttttctg ttaaccttta cttatgacag aataaaattt
    15541 cttggtgtat cgaatttaaa gataaataat aaagtacctc caaattattt ggaagagact
    15601 ttactttttt acctctttag tttttcttca ggaattaaat tattcattaa tttcacattc
    15661 acaccatttc ccacttttat tcaaaatgga aatttagtcc gagagtcatc agcaattagt
    15721 ttataaaaag taaaacagtt atattttagt tttctataaa aatgtttact cttgtttaat
    15781 ccaacacgat tctcaaattc atccgtagaa atatggtttt taagaaacaa ttgatataac
    15841 agtatccatg agctcgatag tgcggttaat tcatccataa tattgtcatc taaatcttcg
    15901 gtgtattctt caattatcat aataattgct agttcatttt tacttcgaat gacatttttc
    15961 acaatatccc tttcaatact attgacccct aaatttttca ataaataaat taaccaaata
    16021 acctctaaat cttttttatg tcttacatac tgtaaaatca gtttttttat tatttttata
    16081 tgattgtcac caaatgtaag tttatcctta tcttttatta ttaattcaca cactttaatt
    16141 aatgatctat tatcattaac taatatatta agtagataag atacataaag ttcgtaatct
    16201 tttacctgga atctttcatt aattgatttc accaagtacc ggatggcacc cttattaccc
    16261 tcattctcta ggttgaagta tttattaaaa attttaataa gatcattaga ttcagcttta
    16321 ctacttacat attcttcata aatcatctga agattttcaa ccacataata aggaaatttt
    16381 acatacttag ttttttcatt attaatcgaa aaatgatatt tcccaagtat atccgaaata
    16441 atagttttgt ataggtctat atctttatct tcgtaaataa taatttcgaa gtcatcgacg
    16501 tatctaacaa aagagactcc agcgctttct atttcttgat caatacgtgt caataaagct
    16561 tcagctagga aaaatgaaag taaaggaccc gtaagcaaac cgtttgttct atttgaattt
    16621 agtcccctca cttttccatc taacttttca tatctcttat atatatcgga aatacgccca
    16681 tctgctttat taccttgaaa atatttatat tgctctatgg ccttatcata acccaacaaa
    16741 atagcaggaa aaatatgagt atatacactg ccataaaaat tagatatatc tagatataaa
    16801 atcccttttc caccttgagc tcgctttatt ttttcagcta tatttggtat ataagttgat
    16861 tgtataaatc tactctcatc caccccttca tcctcaaaat atccataact tgtttcatgc
    16921 ttcaatattt caccattact ttgtactatt tgagaaaatg agttttcact ttcggctgac
    16981 aactcgatta gttctttgat tattttctcg ctatccatat agttaactgc tgaaatataa
    17041 gcagttattt ccggtagatg aattaccctt cgactttcat tatctttaaa tcggctcata
    17101 gtaaatttat aaggctctat gtaatcaata ctattcggta cttctatatc tttgaatata
    17161 tcaaacgttt cactttttaa attaaagtta ctagggagat actctgaaaa aagtccttta
    17221 attttaaatt ccttgactac tttctctatg atttcttctc ctatctcagc ctccataatt
    17281 aggacccact cctctctttt gagattcaaa cttctgtttt actatcactt atggtaaggc
    17341 tccccacgat taattcgaaa agcccgataa atctgctcaa ctagtatgag acgcatcaac
    17401 tgatgaggaa atgtcattct cgagaacgac agcttttcat ccgctcgctt catcaccgcg
    17461 tcactcaatc cgagtgatcc gccaatgacg aaggtgactt tgctttttcc atatgtagcc
    17521 agcttatcta ttgtatcggc tagttcttcg gatgttttca tttttccttc gatggcgagg
    17581 gcgatgacgt gggcgtcggg gctgattttg gataggatgc gttcgccttc tttgtctttt
    17641 atgattttca tgtcctggtc gcttaggttt tccggcgctt tttcgtccgg gagttcgatg
    17701 atgtcgattt ttgcgtaggc cgaaagtcgt ttggtgtatt cttcaatgcc ttgcttgagg
    17761 tatttttctt ttagttttcc gattgtcaca atattgatat tcacaggtca tccccacttt
    17821 aaaaacaagt tattcatata tgttgtccac aattgtggat atcttttctg tattttgtgt
    17881 aagatcattc gttccccact atatatactg cggggtctcc acataattca caggctgtgg
    17941 ataaactgtt agtatgttcg atttttctga tttcgggcgg cagctcgtgg tcgtctatgt
    18001 acatatccag cacggtttcg atgtgttctt cacaggaata ataggtttgt ttcatgttct
    18061 aatcctccga tggtttcttg cgtttttgca aatattctct tcccaatata acctatttat
    18121 tcacatgtta gtagtgcttc gggctgagtt ttatccacaa ttcgacaaac aagctgttga
    18181 tgactctatt tcgcccgtat gttagtttgg atgtaaccga tgtgtgggga gtctgctttt
    18241 gcagctcaaa tgggtttggc tttttgtgat catgttgctg cttgctgggt gtcagccgtc
    18301 ttattgggtg ttggagaagg atcgaatcgg tgaaggcagt ccagacttag aaatatacgc
    18361 taattacctt caaatgcatg atgacgtgaa aggatatcaa gtcttcacca ttttagaagg
    18421 gagaaaaatg gttattgtgt ctctcggaag cagcgagaaa agataagaag cttgaagtgt
    18481 cagacgtcaa attctcacct aaagaaacga ttgtaactgt gaaacgaaaa cctgctccta
    18541 cggcaaatga gaaaaaccct tatattttga ttggactgga caaaatcgca ggggatttca
    18601 tcgtacagga tgaaacggga aaccgatttg aagaaacgga ttaccagcaa taaagccggc
    18661 gttctgagaa cgtccggctt tttcttttac ttcagtgtcc catgcgggtc gatgacgaat
    18721 tttttggctg cgcctttgtc gaagtcgctg tagccttttg gcgcgtcgtc cagagaaatg
    18781 acggtggcgt tgactgcttt tgcgatctgc gctctaccgc tcaggatcgc tttcatcaaa
    18841 ttgcggttgt atgtcatggc gggcgtttgt ccggtgacga aggtgtgggc tttggcccag
    18901 ccgagtccga agcggatttt tagtgagcct gttttggcgt ccgcatcctt tgcaccggga
    18961 tcttcggtca cgtataagcc tggaatgcca aggctgcctc cgacctgggt gacgtccatg
    19021 attgagttca gcacggcggc aggcgcttct ccttgattgc cgtgtccgga tgcttcaaag
    19081 ccgacacagt ccactgcggc atcaacggtt ggttcaccta gtatttgttc aatttgttcg
    19141 ccaaggcggt cgtgtttttg cacgttgacc gtttcacagc cgaagcttct cgcctgtgcc
    19201 agtctgtctt cgttcagatc gccgacaatc acggtggagg cgcctaggag ctgagcggag
    19261 tgagcggctg ctaagccgac aggccccgct cccgcgatat aaacggttga acctgtttgc
    19321 acgcccgctg tgtaagctcc gtggaagccg gtcgggaata tgtccgacag catggtcaaa
    19381 tcgagaatct tttctaacgc ctgttctttc tcagggaata ccaaaagctg aaaatcagcg
    19441 tatggcacca tgacatattc agactggccg ccgacccagc cgcccatatc gacgtagccg
    19501 taagccgatc ccggacggtc cggattgaca ttcaggcaca catgcgtttt ctgcgttttg
    19561 cacatcacac agcgtccgca ggcaatattg aaaggaacgg atacgatatc tccttttttg
    19621 ataaattcaa catcacgccc cgtttcaatg acttctcccg taatttcatg cccgagcacc
    19681 aagccttctg gcgccgttgt gcggcctctg accatatgct ggtcgcttcc gcaaatgttg
    19741 gttgtaatga ctttgagaat aaccccatgc tcacattttc gattcacatt cgccttcgga
    19801 acgccgggcc cgtcccttaa gattaactcc ggataaccga tatcctccac cgctacagtc
    19861 cctttgcctt tgtacacaac cgctttgttt cctgtcaacg ccattcctcc cattcatgtg
    19921 tttggactct tcgtccttgc acatgacttc ggtttggcat gaccctttcc ctttctcacg
    19981 actgtttttt ctgtattctt acaacaacaa atatgccaag aaagcagcca ataatggttc
    20041 cggctatgtc taaaaagtcg actttacatc catttaacag gaacacagta atggccgaaa
    20101 ccaggcagat cataactgcc agaagaataa cccgtttggt gcgcatgtaa ttcctccttt
    20161 ggattcgttt ctaaaacata cccaaaatct ctgcaaactt cggttcaaca aaaaaagaga
    20221 cttcatacca gtctcttcat aatttgagat cactcaaaaa atttcctgag aaataatgtg
    20281 acaatactgg ttaccaacgc aatcgccgta tacataacaa cccaaaacat gaatgagcta
    20341 ttgcccgaag ctaacgtaaa taacaatatc aagctcgcga taaggacgat gagcggtgcc
    20401 acccaaaacc tcttaaataa aaaatgaccc gctataccaa atacacctgc gatgatcgga
    20461 aaaccaaaaa cgataaataa aacggcgatg gctcccatac taacctcctt gccttaaaac
    20521 ctcttcatca cctcaacatc atacagcttc aaatgactct tcggcgtcac gacatccttt
    20581 accttcccaa tctctttttc tttcattttc tttccggttt tcagattgta ctgttcaatg
    20641 taggcaggct tgtgatacgt gtatgtgaag aaatagaggc tgctgccttt ttgggtgatt
    20701 tctttgaaat cggctttcat tttgtccggg gaaagggtga aggcgatgct tgtttttcct
    20761 gtcttggcat cgattttgtg tacctttccg aagccgtcaa tgaaatacag gttcccgtca
    20821 taagggaaaa agctgttttt aaagctgaag ggcatggagc tgtatatcgt ttgttcgtcg
    20881 tttttgtatt cggcgatatc gtgcagctct acttcgccgc tttttttgtt gatcttgacc
    20941 atttgataga gattgtgggc tttttggccg cgaaccataa cataaacagc ttggtcgtcc
    21001 acagcaagct gggattcgac tgaggctcct tcccggtact gccattccgt tactttgtga
    21061 taagtgagct tcttttgatc tgcttgaatc tgaaggagct gatagccttt tccgtcagct
    21121 gtcgggacga gtgcgtaaat ggcgccatca tgaaaaccgg aggctcggat gtagtagggg
    21181 atgacgtctt ttttccactc tccgtccatt tggcggtaca gctctgagcg gtatccttct
    21241 ttctttttgt cgtagccgga gttgtataag gtgtaaaagc cgtccgtgtt ttgcagaaag
    21301 cctgcgctgt cccctgtgtg ctgataggtt cttttatgag atctcaggcc gtctttaatc
    21361 gtatacatcg tgtttttgtc ctccagcatc acgctgtcgc cgtgaacctt ggctgatccc
    21421 agctcaaggc ccttcatctg aaatgaagac agcgacccat cctggctgat aaacagggcg
    21481 tagcttttcc cgccgccaaa tgcatcttga tccgcagagg atgagaaata cagcaggact
    21541 tctttgtcat ccaggaaatc ggggtttctg agatcctgct gactcacggt tttatggctt
    21601 ttgagaggag aaatgaagac aaatagtgcg attcctgcga gaatcagcat ggcgatggta
    21661 atcatccact ttttcatatc cttctcctta gtaaatggt
//
