LOCUS       NZ_NJRD01000006        22129 bp    DNA     linear   CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain 20-3 20-3_R1_(paired)_contig_6, whole
            genome shotgun sequence.
ACCESSION   NZ_NJRD01000006
VERSION     NZ_NJRD01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 315844)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 315844)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010578135.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:42:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,274
            CDSs (total)                      :: 4,198
            Genes (coding)                    :: 4,064
            CDSs (with protein)               :: 4,064
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1 (5S, 16S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 1 (5S, 16S)
            tRNAs                             :: 67
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 80 of 134
            Pseudo Genes (incomplete)         :: 67 of 134
            Pseudo Genes (internal stop)      :: 22 of 134
            Pseudo Genes (multiple problems)  :: 31 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 293715
            Orig. end                         :: 315844
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NJRD01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22129
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="3"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..22129
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22129
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:>22129](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..>22129
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            185..1051
                     /gene="proC"
                     /locus_tag="CE053_RS17870"
     CDS             185..1051
                     /EC_number="1.5.1.2"
                     /GO_function="GO:0004735 - pyrroline-5-carboxylate
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="proC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003231452.1"
                     /locus_tag="CE053_RS17870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="WP_003231452.1"
                     /transl_table=11
                     /translation="MLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQNICVTNRSNT
                     ERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRIQPHQLILSVLA
                     GITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKKLAEALLGCMGEV
                     YTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSIGAQTLLGAAKMLM
                     ETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAKRSKEISEDIEKTAA
                     PLSGVIK"
     gene            1048..2163
                     /gene="proB"
                     /locus_tag="CE053_RS17875"
     CDS             1048..2163
                     /EC_number="2.7.2.11"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004349 - glutamate 5-kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="proB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389729.1"
                     /locus_tag="CE053_RS17875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate 5-kinase"
                     /protein_id="WP_041849903.1"
                     /transl_table=11
                     /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQIVKLKDAG
                     YEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVASQI
                     LITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVAGLI
                     DADMLVILSDIDGLYDGNPRTNPEAKRIQRVSEITPDIEAFAGDTGSIVGTGGMRSKLD
                     AFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEKWIAFNSGPEG
                     EMFLSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVNYSSVQL
                     QEPEKKKELTNRALIDQEAFVCHVDFSLPVN"
     gene            complement(2214..3116)
                     /gene="gltC"
                     /locus_tag="CE053_RS17880"
     CDS             complement(2214..3116)
                     /codon_start=1
                     /gene="gltC"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389728.2"
                     /locus_tag="CE053_RS17880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate biosynthesis transcriptional regulator
                     GltC"
                     /protein_id="WP_004399246.1"
                     /transl_table=11
                     /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNV
                     TLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLASQ
                     LLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKILFT
                     EKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEG
                     EDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPS
                     ANDFYEFVIQFFSKLEQYQ"
     misc_feature    3136..3150
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 22.93"
                     /tool="antismash"
     gene            3263..7825
                     /gene="gltB"
                     /locus_tag="CE053_RS17885"
     CDS             3263..7825
                     /EC_number="1.4.1.13"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0015930 - glutamate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006537 - glutamate biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="gltB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389727.2"
                     /locus_tag="CE053_RS17885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate synthase large subunit"
                     /protein_id="WP_163182394.1"
                     /transl_table=11
                     /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLKM
                     LCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKDINLPEKERYGVGMVFFSQKEDE
                     RKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKENLS
                     FERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEAFVSA
                     FALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFGEDLNK
                     ILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRAFYEYHS
                     SLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIEVEQENVL
                     YKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDPESREEEQF
                     SDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQSLFNYFKQLF
                     AQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSNEQFYALKTIV
                     HPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNERLTPIPPLLAV
                     SALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLAYATYKQEIDEGR
                     LDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGISRDVIDRYFTGTA
                     SQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEHHAFNPKTIHTLQWA
                     CRRNDYSLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVESAESIVKRFKTGAMSF
                     GSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDRRSAIKQIASGRFGVKS
                     HYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTPGVGLISPPPHHDIYSIE
                     DLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATADVIVISGYDGGTGASPKTS
                     IKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGRDVVMAALLGAEEFGFATAP
                     LVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHIVNYMLFIAEEVREYMAALGF
                     KTFDEMIGRTDVLHVSERAKGHWKASQLDLSTLLYQPEGVRTFRSPQNHKIDQSLDITT
                     ILPAVQEAIESGKEADISIEINNTNRVAGTITGSEISKRYGEEGLPEDTIKLHFTGSAG
                     QSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKSPEGFNSASDDNVIIGNVAFYGAT
                     SGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEYMTGGSVVVLGDVGKNFAAGMSGGI
                     AYVLAEDVKAFKRKCNLEMILFESLEDEKEIQQIKAMLERHTAYTNSQKAEDLLDQWED
                     SVKKFVKVIPKNYKQMLASIQEQKAAGLSDEEAIMFAFEANTKPKQNTAASGQKQAVVQ
                     "
     gene            7842..9323
                     /gene="gltD"
                     /locus_tag="CE053_RS17890"
     CDS             7842..9323
                     /EC_number="1.4.1.-"
                     /GO_component="GO:0009342 - glutamate synthase complex
                     (NADPH) [Evidence IEA]"
                     /GO_function="GO:0045181 - glutamate synthase activity,
                     NAD(P)H as acceptor [Evidence IEA]"
                     /GO_process="GO:0006537 - glutamate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gltD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1285: ferredoxin fdxC"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389726.2"
                     /locus_tag="CE053_RS17890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate synthase small subunit"
                     /protein_id="WP_032721970.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 8.8e-28, bitscore:
                     91.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKPTGFMEIKREKPSERDPLTRLKDWKEYSAPFSEEASKRQGAR
                     CMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFTGR
                     VCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGSGPA
                     GLASADQLNQAGHSVTVFERSDRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGIDFVTN
                     TEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKSYLDSN
                     FKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTNDNMWPE
                     QPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVKNEHGKYE
                     FRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVDSVNNKISAAYGDYQTNIDGVFAA
                     GDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP"
     misc_feature    7860..7873
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.8"
                     /tool="antismash"
     gene            complement(9380..10369)
                     /gene="yogA"
                     /locus_tag="CE053_RS17895"
     CDS             complement(9380..10369)
                     /NRPS_PKS="Domain: PKS_ER (11-324). E-value: 6.8e-40.
                     Score: 129.0. Matches aSDomain:
                     nrpspksdomains_CE053_RS17895_PKS_ER.1"
                     /codon_start=1
                     /gene="yogA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389725.1"
                     /locus_tag="CE053_RS17895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_032721969.1"
                     /sec_met_domain="ADH_N (E-value: 3.6e-13, bitscore: 43.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-28, bitscore:
                     94.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVIHNGKAGLQGLSVEDVPSTKPGYGEVKVKLKSAGLNHRDLF
                     LMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPEIL
                     GGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEHLLI
                     PGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALQLGADYAFDSYSNWDEQLQGKKA
                     DVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTSMGSGE
                     EFQAMLAFINKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME"
     aSDomain        complement(9398..10336)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE053_RS17895_PKS_ER.1"
                     /evalue="6.80E-40"
                     /label="CE053_RS17895_PKS_ER.1"
                     /locus_tag="CE053_RS17895"
                     /protein_end="324"
                     /protein_start="11"
                     /score="129.0"
                     /tool="antismash"
                     /translation="LQGLSVEDVPSTKPGYGEVKVKLKSAGLNHRDLFLMKNKSEQDPH
                     MILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPEILGGPSDGTLAEY
                     VIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEHLLIPGIGSGVATYA
                     LFMAKAIGATVSVTSRSEEKRKKALQLGADYAFDSYSNWDEQLQGKKADVVLDSIGPAL
                     FSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTSMGSGEEFQAMLAFINK
                     HKLRPVIDRIYPLEKACEAYKRMQEGRQFGNI"
     gene            10498..11355
                     /gene="yofA"
                     /locus_tag="CE053_RS17900"
     CDS             10498..11355
                     /codon_start=1
                     /gene="yofA"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389724.1"
                     /locus_tag="CE053_RS17900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator YofA"
                     /protein_id="WP_032721968.1"
                     /transl_table=11
                     /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLNI
                     RLFHRTNRGMKLTAAGENLLQYADQVLSLLDKAEKSTRMSRQPKGPLRIGSLETTAVTH
                     LPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVSHDE
                     LVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIDNQKIIKFGTLEAIIKGV
                     SAGMGTALLPKSSVDCSEHRTNVWIHQLPPAYQDLEIVFIYRKDFFITSAFQTFLDEIN
                     EMKR"
     gene            complement(11518..13281)
                     /gene="ggt"
                     /locus_tag="CE053_RS17905"
     CDS             complement(11518..13281)
                     /EC_number="2.3.2.2"
                     /GO_function="GO:0036374 - glutathione hydrolase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006750 - glutathione biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006751 - glutathione catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ggt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1274: gamma-glutamyltranspeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389723.1"
                     /locus_tag="CE053_RS17905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gamma-glutamyltransferase"
                     /protein_id="WP_032721967.1"
                     /transl_table=11
                     /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVGK
                     DGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDGKT
                     KDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDKWGT
                     RSMKQLITPSIKLAEKGFPIDSVLADAISDYQEKLSRTAAKDVFLPNGEPLKEGDTLIQ
                     KNLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPIWGDYQ
                     GYQIATTPPPSSGGIFLLQMLKILDDFNLSQYDVRSWEKYQLLAETMHLSYADRASYAG
                     DPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQVEQPKDKV
                     EGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIPGGANEVQP
                     NKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELKAAVEEPRIY
                     TNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGTFKGVADSSRN
                     GAAIGINLKRK"
     misc_feature    complement(13321..13337)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.85"
                     /tool="antismash"
     misc_feature    complement(13355..13373)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            13466..13696
                     /gene="yoeD"
                     /locus_tag="CE053_RS17910"
     CDS             13466..13696
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="yoeD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389722.1"
                     /locus_tag="CE053_RS17910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="excisionase family DNA-binding protein"
                     /protein_id="WP_032721965.1"
                     /transl_table=11
                     /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQFK
                     THLEQLENYKALVHEILNEPIPEDIDVKDED"
     gene            14012..14557
                     /gene="yoeC"
                     /locus_tag="CE053_RS17915"
     CDS             14012..14557
                     /codon_start=1
                     /gene="yoeC"
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389721.2"
                     /locus_tag="CE053_RS17915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /protein_id="WP_003231473.1"
                     /transl_table=11
                     /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDIL
                     PLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRKPI
                     SRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSITMRY
                     IGIDEDTTRAAYKVFGGL"
     tRNA            14610..14682
                     /anticodon=(pos:308358..308360,aa:Arg,seq:cct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CE053_RS17920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Arg"
     gene            14610..14682
                     /locus_tag="CE053_RS17920"
     gene            complement(14776..15321)
                     /gene="iseA"
                     /locus_tag="CE053_RS17925"
     CDS             complement(14776..15321)
                     /codon_start=1
                     /gene="iseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389720.2"
                     /locus_tag="CE053_RS17925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DL-endopeptidase inhibitor IseA"
                     /protein_id="WP_004399558.1"
                     /transl_table=11
                     /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSAREH
                     FWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEKGF
                     KDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAKRKV
                     TFVKENKKWKVNQFDAVI"
     misc_feature    complement(15549..15562)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.34"
                     /tool="antismash"
     gene            15607..16998
                     /gene="yoeA"
                     /locus_tag="CE053_RS17930"
     CDS             15607..16998
                     /codon_start=1
                     /gene="yoeA"
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389719.2"
                     /locus_tag="CE053_RS17930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MATE family efflux transporter"
                     /protein_id="WP_004399508.1"
                     /transl_table=11
                     /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGMM
                     AVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGTTL
                     TFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYTTFL
                     RGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFLVLMV
                     YLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFVNHYGS
                     NATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWLNYIIGG
                     VLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMRASGTVLW
                     PTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQFVWKKKQI
                     TRLIQ"
     misc_feature    17032..17041
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            17132..18109
                     /gene="galM"
                     /locus_tag="CE053_RS17935"
     CDS             17132..18109
                     /EC_number="5.1.3.3"
                     /codon_start=1
                     /gene="galM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389718.1"
                     /locus_tag="CE053_RS17935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldose 1-epimerase"
                     /protein_id="WP_085187610.1"
                     /transl_table=11
                     /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTNV
                     QLLREPETAESFHDTPTLYGIPILFPPNRIGDGTFSFRGRTYHFDINEKDKHNHLHGFL
                     YHEKWNVVTTKQTDEGVIVETEIDLSELPHVQNQFPHHAVVRMTYTIKGNTLFKHATVM
                     NKGKEAFPWGIGYHTTFVFPAESSLFSLTADQQWELDERLLPTGKLMDVPNKEALHEGM
                     DLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFNHWVVYNADGKQGYLC
                     PEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ"
     gene            18143..19618
                     /gene="dacB"
                     /locus_tag="CE053_RS17940"
     CDS             18143..19618
                     /EC_number="3.4.16.4"
                     /GO_function="GO:0004175 - endopeptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0009002 - serine-type D-Ala-D-Ala
                     carboxypeptidase activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="dacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389717.1"
                     /locus_tag="CE053_RS17940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="D-alanyl-D-alanine
                     carboxypeptidase/D-alanyl-D-alanine-endopeptidase"
                     /protein_id="WP_085187614.1"
                     /transl_table=11
                     /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSEQIDKILA
                     DHSALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTE
                     VRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEKLKHSGVKVIKGNLIGDDTWHDD
                     MRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVSPKTD
                     YITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAGYALDL
                     FKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEM
                     GKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD
                     QSWFSAYLNSLPVAGNPDRMVGGTLRNRMKDTPAQGKVRAKTGSLSTVSSLSGYAETKS
                     GKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ"
     misc_feature    19791..19804
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     gene            20001..>22129
                     /gene="ppsA"
                     /locus_tag="CE053_RS17945"
                     /pseudo=""
     CDS             20001..>22129
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Condensation_Starter (3-300). E-value:
                     7.5e-92. Score: 299.8. Matches aSDomain:
                     nrpspksdomains_CE053_RS17945_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (463-705). E-value: 1.4e-61.
                     Score: 200.2. Matches aSDomain:
                     nrpspksdomains_CE053_RS17945_AMP-binding.1"
                     /codon_start=1
                     /gene="ppsA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389716.2"
                     /locus_tag="CE053_RS17945"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="plipastatin non-ribosomal peptide synthetase
                     PpsA"
                     /pseudo=""
                     /sec_met_domain="Condensation (E-value: 4.8e-76, bitscore:
                     250.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-57, bitscore:
                     188.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELHTL
                     EGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQDQA
                     SIPFKLFNSPLYQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKKKDP
                     LPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQSTSAS
                     RDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGNRGSKA
                     EKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNELRNEQKD
                     LHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQLNFDYQN
                     TLFSLEDIKRIQSHLLTILENALQHPHSFIRELDMTNTREKQKLLYEFNKTEAVSPKAF
                     TLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVSNESIVGVLSER
                     SPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSAPNFSGETLE
                     VDMTSLAREKAENHLFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAVSFLTGMQHQFP
                     LSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVKAIHQEKVTTAH
                     FIPAMLNSFLDQAEM"
     aSDomain        20010..20900
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE053_RS17945_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="7.50E-92"
                     /label="CE053_RS17945_Condensation_Starter.1"
                     /locus_tag="CE053_RS17945"
                     /protein_end="300"
                     /protein_start="3"
                     /score="299.8"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIIMDG"
                     /tool="antismash"
                     /translation="HTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELHTLEGA
                     LNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQDQASIP
                     FKLFNSPLYQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKKKDPLPD
                     QPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQSTSASRDT
                     IILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGNRGSKAEKE
                     MLGMFVSSLPIRITVD"
     aSModule        20010..22115
                     /domains="nrpspksdomains_CE053_RS17945_Condensation_Starter
                     .1"
                     /domains="nrpspksdomains_CE053_RS17945_AMP-binding.1"
                     /incomplete
                     /locus_tags="CE053_RS17945"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       20016..20054
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE053_RS17945_0001"
                     /evalue="4.00E-03"
                     /label="C1_starter_004-017"
                     /locus_tag="CE053_RS17945"
                     /protein_end="18"
                     /protein_start="5"
                     /score="10.1"
                     /tool="antismash"
                     /translation="YSLTHAQRRVWFT"
     CDS_motif       20079..20195
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE053_RS17945_0002"
                     /evalue="1.70E-07"
                     /label="C2_starter_024-063"
                     /locus_tag="CE053_RS17945"
                     /protein_end="65"
                     /protein_start="26"
                     /score="23.9"
                     /tool="antismash"
                     /translation="ICNLTACVKFKGNIELHTLEGALNHSISRNDAIRFQLLE"
     CDS_motif       20400..20465
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE053_RS17945_0003"
                     /evalue="7.00E-08"
                     /label="C3_starter_134-155"
                     /locus_tag="CE053_RS17945"
                     /protein_end="155"
                     /protein_start="133"
                     /score="25.3"
                     /tool="antismash"
                     /translation="FHHIIMDGISLNVMGNQIIDLY"
     CDS_motif       20799..20888
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE053_RS17945_0004"
                     /evalue="8.90E-09"
                     /label="C5_starter_265-294"
                     /locus_tag="CE053_RS17945"
                     /protein_end="296"
                     /protein_start="266"
                     /score="27.8"
                     /tool="antismash"
                     /translation="DLAIGTYYGNRGSKAEKEMLGMFVSSLPIR"
     CDS_motif       20940..21053
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE053_RS17945_0005"
                     /evalue="3.30E-09"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="CE053_RS17945"
                     /protein_end="351"
                     /protein_start="313"
                     /score="29.3"
                     /tool="antismash"
                     /translation="REQLSVMRHQRFPYNLLVNELRNEQKDLHNLIGISMQY"
     aSDomain        21390..22115
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE053_RS17945_AMP-binding.1"
                     /evalue="1.40E-61"
                     /label="CE053_RS17945_AMP-binding.1"
                     /locus_tag="CE053_RS17945"
                     /protein_end="705"
                     /protein_start="463"
                     /score="200.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVSNE
                     SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSA
                     PNFSGETLEVDMTSLAREKAENHLFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAVSF
                     LTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVKAI
                     HQEKVTTAHFIPAMLNSFLD"
     CDS_motif       21576..21617
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE053_RS17945_0006"
                     /evalue="4.10E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="CE053_RS17945"
                     /protein_end="539"
                     /protein_start="525"
                     /score="19.8"
                     /tool="antismash"
                     /translation="LAVLKAGGAYLPLD"
     CDS_motif       21801..21860
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE053_RS17945_0007"
                     /evalue="2.80E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="CE053_RS17945"
                     /protein_end="620"
                     /protein_start="600"
                     /score="35.1"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGQPKGVAVEH"
ORIGIN
        1 aatttttaat agaaacaaac acccggcgca gcagtgtgaa ccgggtgttt tctgcttttc
       61 attatacata tttgtcgaaa agaaacaata caaatcaatg atgaccttca aacttgacat
      121 catttcctca cgtggtaaca ttttaaacgt gtgaaaatgc gaacaaaaaa cgcgaacaaa
      181 ggagatgtta ccgatctttg atcaaaagaa agttgccttt ataggagcag gatctatggc
      241 ggaaggaatg atatcaggta tcgttcgtgc caacaaaatc ccgaaacaaa acatctgcgt
      301 tacaaaccgc agcaatacag agcgattaac tgaacttgaa cttcaatatg gcattaaagg
      361 cgccttgccg aaccaactat gtattgaaga catggatgtg ctcattttgg caatgaagcc
      421 aaaagacgcc gaaaacgctc tgtcatcact aaaatcacgt attcaacccc atcaattaat
      481 attgtcggtc cttgccggca taaccacctc ttttattgaa caatcattgc ttaatgaaca
      541 gccggttgtc agagtgatgc ccaacacttc cagtatgatt ggcgcttctg caacagctat
      601 tgcccttggc aaatatgtgt cggaagacct gaagaagctg gccgaagcat tgctcggatg
      661 catgggcgaa gtctatacaa tccaagaaaa tcaaatggat atattcaccg gaattgcagg
      721 cagcggaccc gcgtattttt attatttaat ggaattcatt gaaaagacag gcgaggaagc
      781 gggcctcgat aaacagttat ctcgaagcat cggcgcacag acacttttag gtgccgcaaa
      841 aatgctcatg gaaacaggag aacatcctga gatcttaaga gataatatca cgtcaccgaa
      901 cggaacgaca gcagcggggc tgcaagcctt gaaaaagagc ggcggcggag aagcgatttc
      961 tcaagcaata aagcatgcgg ctaagcgttc aaaggaaatc agcgaagata tcgaaaaaac
     1021 tgcagcgccg ctatcaggag tgataaagtg acgcctgata caagcatgaa aagagtcgtt
     1081 gtgaagattg gcagcagttc attaacaagc cttcatggag aaatcagcat tcgaaaatta
     1141 gaagcgctgg tcgaccagat cgtcaaactc aaagacgccg gttatgaagt aattttggtt
     1201 tcctcaggcg cagtggcggc gggatatcgg aagctcggat ttatccaaag gcccgagaag
     1261 cttccagaaa aacaagcatc agcttcaatc ggccagggat tgctgatgga ggcttattca
     1321 aagctgttct tggcacacgg ctatgtcgca tcccaaattt taattacgag aagcgatttt
     1381 tctgatgaat atcgatacaa caatgtcagg aatacaatga atgtactgct cgagcgcggc
     1441 atcatcccga tcataaacga aaatgataca gttaccgtca atcggctcaa gtttggcgac
     1501 aatgatacac tcgcggcaaa agtcgcagga ttgattgatg cagatatgct tgtgatttta
     1561 tcagatatag acggattata tgacggcaat ccgcgcacaa atccagaagc gaaaaggata
     1621 cagcgggtga gtgaaataac acctgacatc gaagcattcg caggtgacac tggaagcatc
     1681 gttggcaccg gcggcatgcg ctctaagctt gatgcgttta aaatcgtaat ggcgtctggc
     1741 attaaaggtt tccttggtca ggcagatgct ggcgatattt tatatcacgc cgttcatgaa
     1801 caggcggaag gcacctattt tgaagcagaa ggaacgcttc cgttgaatca aaaggagaaa
     1861 tggatcgctt ttaattccgg tccggaaggt gaaatgtttt tatcagatga ctgttcacga
     1921 aaaataacaa acggccaatc gagtttatac ctggacggtg tacagaagat taaagggaaa
     1981 ttcaaaagcg gttcagttgt tcggctgatg gattcaaaag ggacggaaat cggccttgga
     2041 atcgtcaatt actcttctgt acagcttcaa gaaccggaaa agaaaaagga actgacaaac
     2101 agagctctaa ttgatcaaga agcctttgtt tgccatgtgg atttttcttt acctgtaaat
     2161 taatttgcag aaaaaaaccc gaagcttcta tatagaagct cgggttcatt tttttattga
     2221 tactgctcca gcttagagaa aaattgaatg acaaactcat aaaaatcatt cgcggaaggc
     2281 gcaagctctc tatttttcgg tttaatgatt ccgacagtcc gttttacttg agggaactca
     2341 attggaattt tcacagtaaa acgaggtgtt gtttcagcaa aagtactttc aggcagaagg
     2401 gtaacgccca ttcctgcgga cactaaccct ttgatagcat ccaaatcctc accctccgtg
     2461 gaaacgagag gagcaaagcc tgcttgtttg caagtatcga ttgccatctc tctaagtaca
     2521 aatccttccg ggaacaatac aaattggtcg ttgcgcaaat cgattaaatg aaccgttttt
     2581 tgtttagcaa gcggatgatt taatggaaca agcgcgtaaa ttttttcagt aaataatatt
     2641 tttcccgtta tgtcagagaa attcgtcggc accggtccta ataaggccag atcaatatcg
     2701 cggtttctga cagcttcaat cagaaactta taggagcctt ggcgcagcaa aaattcgacg
     2761 tgcggatatt cttctttaaa cgctgaaatg acagtcggca aaagctggct ggcgaggctt
     2821 gtaggaaagc cgatctttac cgttccgcga tgcgggtcaa gatactcatc aatttgctct
     2881 ttcgcataat caatggcttt catcgccgtt ttcacatgaa tcaaaaattc ttttccgatt
     2941 ggcgtgagtt tgatatttct cccttcacgc tcaaataagg tcacatttaa ttcttcttca
     3001 agattggcaa tttgtctgct gattgctgat tgggccacat gcaaatgatc agcggcttct
     3061 gaaacgtgtt ctctttcagc cacctccatg aaataacgca gttggcgcag ctccatgttt
     3121 gtctcacatc catctatctc attttgagat tcttttgatc taaattatat attgtttata
     3181 tcgttttgaa aacctacaat gattatagag ttgttagatt ttatgaccgg tattatcgga
     3241 aattgatcgg gggagaggaa ttatgacgta caatcaaatg ccaaaagctc aaggtctcta
     3301 ccgtcctgaa tttgaacatg atgcatgcgg aatcggccta tatgcacact taaagggcaa
     3361 gcagactcac gacattgtca aacaaggact taagatgctt tgccagctag accatagagg
     3421 agggcaaggc agtgatccgg atacaggaga cggagccggc ttactggttc aaatccctga
     3481 tgctttcttt agaaaagagt gcaaagacat caatctgcca gaaaaagaac gttacggggt
     3541 aggaatggtc tttttctcac agaaagaaga tgaaagaaaa aaaattgaaa agcaaatcaa
     3601 tgcactgatt gaacaagaag gccaagtcgt tcttggatgg agaactgtac ctgtaaatgt
     3661 cggaaaaatc ggaacagtgg cgcaaaaaag ctgtccgttt gtccgtcagg tatttatcgg
     3721 cgcaagttct gatctaaagg aaaatttatc ttttgaacga aaattgtatg tcattcgtaa
     3781 acaggctgaa aattggggag taacggaagg tcttgatttt tattttgcca gtctttcaag
     3841 ccagaccatt gtttacaaag gccttttaac acctgaacag gttgatgcat tttattctga
     3901 tctgcaagac gaagcattcg tttctgcttt tgcgcttgtt cattcacgct tcagtaccaa
     3961 tacattccct acatgggaaa gagcgcatcc taaccgctat ttggttcaca acggtgaaat
     4021 taacaccctt cgcggaaata tcaactggat gagagcacgt gagcagcaat ttgtttctga
     4081 aagcttcggt gaggacttaa acaagatttt gccgattctc aatgctgatg gcagtgactc
     4141 ttccattttg gataacgcat ttgagttttt tgtgatggct ggacgcaaac cggcacatac
     4201 ggcaatgatg ctcattccag agccttggac ggaaaatacg catatgtcca aggaaaaaag
     4261 ggcgttttac gagtaccata gctccctgat ggagccttgg gacggaccga cagccatttc
     4321 atttactgac ggtaaacaaa tcggggcaat ccttgaccgg aatggtctcc gtccagcccg
     4381 ttattatgtc acaaaagatg attatattat tttctcatct gaagtaggcg ttattgaagt
     4441 tgaacaggag aacgttttat ataaaaaccg ccttgagcct gggaaaatgc ttttaatcga
     4501 cctggaagaa ggccgtatta tctccgatga ggaagtcaaa acacaaattg caactgagta
     4561 tccgtaccaa aaatggcttg aagaagagct tgtacaagta aatcctgatc cggagtcaag
     4621 agaagaagaa caatttagtg atcttcttac tcgccagaag gcattcggat acacatatga
     4681 ggatatccaa aaatatctaa ttcccgttat taaagaaggc aaagatcccc ttggttcaat
     4741 ggggaatgac gcgccgcttg ctgtactttc tgaccgagcg caatcactgt ttaactactt
     4801 taaacagctg tttgcacaag taacgaaccc gccaatcgac gcgattcgtg agcagcttgt
     4861 cacttcaacg atgacttggc tcggtgcgga aggcgatctt cttcatccaa gtgaacgaaa
     4921 tgttcgccgg attaaactgt atacacctgt tttatccaat gaacagtttt acgcattgaa
     4981 aacgattgtt catcctgatt taaaaagcca aaaaattgat gtgctgtttt cagaggatct
     5041 tgaacgcgga ttaaaggaca tgttcacaca agcagagaaa gccatcagcc aaggcgtaag
     5101 tttgttaatt ttatcagaca aaaagatgaa cgaacgactg acaccaattc cgccgcttct
     5161 ggcagtaagc gcgctgcacc agcacttaat ccgcaaaggg ctgcgtacga aggtcagcat
     5221 tattgtggaa tcgggagaag cacgtgaagt gcatcacttt gcagcgttaa tcggttatgg
     5281 cgcagatgcg attaaccctt atctcgctta tgcgacctac aagcaggaaa ttgatgaagg
     5341 ccgtttggat atcagctatg aagaagcggt cagcaaatat ggaaaaagca ttactgaggg
     5401 cgtcgtaaaa gtgatgtcca agatgggaat ttcaactgtg caaagctaca gaggcgccca
     5461 aatctttgaa gcggtaggaa tcagccgcga tgtgatcgac cgctatttca caggtactgc
     5521 atcacagcta ggcggcatcg atttacaaac aattgcagaa gaggcacagc gccgccaccg
     5581 ggaagcgtat caggatgatt acagcaaaac gcttgaaccg ggaagtgact tccaatggag
     5641 aaatggcgga gagcatcatg cctttaatcc gaaaacgatt catactttgc aatgggcgtg
     5701 ccgcagaaat gattacagtc tgtttaaaca gtatacaaaa gcggctgatg aagaacgcat
     5761 cggatttttg cggaacttgt tcgcatttga cggaaaccgc aagcctttga agttggagga
     5821 ggttgaatcc gctgaatcga ttgtcaaacg ttttaaaacg ggtgcgatgt cattcgggtc
     5881 cttgagtaag gaagcgcacg aagctttagc aatcgcaatg aaccgtcttg gaggaaaaag
     5941 caacagcggt gaaggcggag aagatcccaa acgctttgtt ccagatgaga acggcgatga
     6001 tagaagaagt gcgatcaaac aaattgcatc cggacggttt ggtgtcaaaa gccattacct
     6061 cgtcaatgct gatgagctgc agattaaaat ggctcaaggt gctaagccgg gtgaaggcgg
     6121 tcagcttcct ggcaacaagg tatatccatg ggttgccgat gtccgcgggt caacgccagg
     6181 tgtcggatta atctcacctc cgccacacca tgacatttat tcgattgagg atttagccca
     6241 gctgatccac gatttgaaaa atgccaaccg tgacgcaaga atcagcgtaa agctggtgtc
     6301 aaaagcaggt gtaggaacaa tcgctgcagg tgttgccaaa gcgactgcag atgtcattgt
     6361 gatcagcggc tatgacggag gtacaggcgc ttctccgaaa accagtatta aacatacagg
     6421 gcttccgtgg gagcttggcc ttgcagaagc acatcaaaca ctaatgctga acggacttcg
     6481 tgaccgtgtt gtattagaaa cagacggaaa gctcatgacg ggccgcgacg ttgtgatggc
     6541 tgccttgctc ggcgccgaag aatttggttt cgcaacggct ccgttagttg tactcggctg
     6601 tgtcatgatg cgtgcctgcc atttggatac atgccctgtc ggtgtagcga cacaaaaccc
     6661 agagcttcgc aaaaagttca tgggggatcc tgaccatatt gtgaactata tgctgttcat
     6721 tgctgaagag gttcgtgagt acatggctgc gttaggcttc aagacatttg atgaaatgat
     6781 cggccgcact gatgtacttc atgtaagtga acgggcgaag gggcactgga aagcaagcca
     6841 gcttgatttg tctacacttc tttatcagcc tgaaggggtg cggacgttcc gatcgccgca
     6901 aaatcataaa attgatcaat cgcttgatat cacaacaatt ctcccggctg tacaagaagc
     6961 catcgaatct ggaaaagaag ctgatatttc gattgaaatc aataatacaa atcgtgtagc
     7021 cggaacgata accggcagtg aaatctcaaa gcgttacgga gaagaaggtc ttcctgaaga
     7081 tacaatcaag ctgcacttta ccggatcagc cggccaaagc tttggagctt tcgttcctaa
     7141 agggatgacg ctttatttgg acggagactc aaatgattac gtcggaaaag ggctttctgg
     7201 cggaaaaatc atcgtcaagt caccagaagg attcaactct gcttcggatg acaatgtcat
     7261 tatcggcaac gtggcttttt acggtgcgac aagcggagaa gcatatatta acggacgtgc
     7321 tggtgaacgc tttgccgttc gaaacagcgg tgtgaacgta gttgtagaag gtattggcga
     7381 ccacggctgt gaatacatga ctggcggcag cgttgtcgtt ctcggtgatg taggcaaaaa
     7441 ctttgcggca ggtatgtccg gcggaatcgc ttatgtactg gccgaagatg tcaaagcgtt
     7501 taaacgcaaa tgcaaccttg agatgatttt atttgaatca ttagaggacg agaaagaaat
     7561 ccagcaaatc aaagcaatgc ttgaaagaca tactgcatat acaaacagcc aaaaagcaga
     7621 agatttgctt gatcaatggg aagacagtgt gaaaaaattc gtcaaagtca ttccgaaaaa
     7681 ctataaacaa atgcttgcaa gcatccaaga gcaaaaagct gcaggtttat cagatgaaga
     7741 agccatcatg ttcgcttttg aggccaacac gaagccaaag cagaatacag cagcatcggg
     7801 acaaaaacaa gcggtagtac agtaaggaag gggagaggaa catggggaaa ccaactggat
     7861 ttatggagat caaacgagaa aaaccttcgg agcgggaccc tctcactcgc ttaaaggatt
     7921 ggaaagaata ttctgctcct ttttcagaag aagcatcgaa acggcagggg gcgcggtgta
     7981 tggattgcgg tacaccgttt tgccagatcg gtgcggacat taacggattt acatccggct
     8041 gtccgattta caacttaatt cctgaatgga atgatcttgt ctaccggggc agatggaagg
     8101 aagcattgga acgtctgttg aaaacaaaca actttcctga attcacaggg cgggtatgtc
     8161 ccgctccttg tgaaggatca tgcactttag cgatttcaga cccggccgta tcaattaaaa
     8221 acatcgagcg gaccattatc gataaaggat ttgagaacgg ctggattcaa cctagaattc
     8281 caaaaaaacg aacaggcaaa aaagttgcta tcgtcgggtc gggcccagcc ggactggcga
     8341 gtgctgacca gctgaatcaa gcggggcatt ctgtcactgt ttttgagcgc tcagacagag
     8401 cgggcggcct tttaacatac ggcattccaa acatgaagct tgagaagggc attgtagaac
     8461 gccgaattaa attgctgacg caagagggaa ttgattttgt cacgaacaca gaaatcggtg
     8521 ttgacattac agctgatgag ctaaaggagc aatttgatgc tgtgatccta tgcacaggcg
     8581 ctcaaaaaca gcgggacctc ttaattgaag gacgcgattc aaaaggagtc cattacgcga
     8641 tggactacct gacacttgca acaaaaagct atttagattc taattttaaa gacaagcaat
     8701 tcattgatgc caaagggaaa gatgtcatcg taatcggagg cggagataca ggagctgact
     8761 gtgtggctac tgctctgcgt caaaaagcca aaagcgtgca ccaattcggc aaacacccga
     8821 aacttccgcc agcccgcacg aatgacaata tgtggcctga acagccacac gtctttacgc
     8881 ttgaatatgc atacgaggaa gcagaagcaa aattcggaag agatccgaga gaatactcca
     8941 ttcaaacgac aaaaatggtt gcggataaaa acggaaagct gaaagagctt cataccatcc
     9001 aaatggaaaa agtgaaaaat gagcatggaa aatacgagtt ccgcgagctg cctggaacgg
     9061 aaaaagtatg gcctgctcag cttgtcttta tcgctatcgg ctttgaaggc acagaacagc
     9121 cgctgttgaa acagtttggt gttgattctg taaataacaa aatcagtgca gcatatgggg
     9181 attatcaaac aaatatcgat ggtgtattcg ccgcagggga tgcaagaaga ggccaaagct
     9241 taatcgtatg ggcgattaat gaaggccgtg aagtggcgcg tgaagtggat cgatatttga
     9301 tggggagttc agttcttccg taaataaagg ggattatcat ataagagaaa ccggtctggc
     9361 tgccagccgg tttctttttt tattccatta cgatcccgat gtttccaaac tgtctgcctt
     9421 cctgcattct tttatatgct tcacatgctt tttctaaagg atatatccgg tcaattacag
     9481 gccgcagctt atgtttgtta atgaaagcga gcatagcttg aaattcctca ccgcttccca
     9541 tcgaggttcc caaaacattg acctgaggaa agaatagaga acgcaccgga aaactgagat
     9601 tatcccctga gcttgcccca aagctgacaa tacggccatt tggttttaca tggcggaagt
     9661 attccgaaaa gagggcaggt cctatgctgt caagaacaac atccgccttt tttccctgca
     9721 actgctcatc ccaattgctg tagctgtcaa atgcgtaatc agcacctaat tgcagcgcct
     9781 tttttctttt ctcctcactg cgggaggtca cgcttactgt tgccccaatc gccttagcca
     9841 taaataaagc ataggttgcc acaccgctgc cgatgccggg tatcaataga tgctcgcctt
     9901 tttttaattg cccctttgta aacagagccc gatatgcagt taaagcggat aaaggtaaaa
     9961 cgcccgcttc ttcccaagat aaataagcag gttttttgat tgcattttgt gaaggaatga
    10021 tcacatattc agcaagtgtt ccgtccgaag gacctcccag aatctcaggt acaggtggta
    10081 cattctctgt taaatcccag ttcaatgtcg ggaaaatgac tacttctgtc tgaacagtaa
    10141 catttttcac gccttcacca atctcttcga tgatacccgc gccgtcagaa cccagtatca
    10201 tgtgaggatc ttgttccgat ttgtttttca taagaaacaa gtcacgatga ttcaggcccg
    10261 cggattttaa tttaaccttt acctctccgt atccaggctt tgttgatgga acgtcctcga
    10321 ctgataaccc ctgaaggccg gcttttccgt tgtgaattac agctttcatg ctgtctgcct
    10381 cctcattgaa ttgtattttc atatctttac atattttaca tagcggtttt cttcgagtaa
    10441 aatgaacaaa tatgatagcc aatatcactt ttcatcatag caagcaggtg agagcgcgtg
    10501 gaaagcggag atttaaagat ttttcaggct gttgctcgcg aaggaagcat aacgaaagca
    10561 gcccaaatgc tgaattatgt tcagtcgaat gtgacagcca gagtgcataa ccttgaggaa
    10621 gatttgaata tcaggctttt tcatcgaacg aatcggggga tgaagctgac tgctgcagga
    10681 gaaaatcttt tacaatatgc agatcaagta ttatcgctgt tagacaaagc tgaaaaatcg
    10741 acccgtatga gcaggcaacc aaaagggcct ttgcggatcg gatcactgga aacgacggcg
    10801 gtaacgcatc tgcctgagca tgcagcatcc ttcctcaggc gttttcctga agtggattta
    10861 tcagtgaaca cagcggatac gcatcatttg attcaacagg ttcttgatca taaagttgat
    10921 ggcgcttttg tatatgggcc ggttgaacac gctgcagtta gacaactcca tgtttcccat
    10981 gatgaattag ttttgatttc atcacgagaa gggacggcag aagacatgct tcagcagccg
    11041 atgctctttt ttggggctgg ctgttctcat cgtgacaggg tcaaaagatt actagaggaa
    11101 gcaggcatag acaatcaaaa aatcataaag tttggcacat tggaggctat tataaaaggt
    11161 gtttccgccg ggatgggtac ggcgctgctc ccaaagtcct ctgttgactg ctccgagcat
    11221 cgtacaaatg tatggattca tcaattgcca ccagcatatc aagacttaga gatcgtcttt
    11281 atatacagga aagacttttt tattacgagt gcgtttcaga catttcttga tgagataaac
    11341 gaaatgaaaa gatgaagata gacgtgcatt agcagaataa agattttgtc aaagaagcag
    11401 tcatcattct gtcattttgg attgcaatca gggatacaga gcatcagcaa tgcccgttgt
    11461 tattaaagat ctgcatgaaa aaactgtact catttgaagc gagtacagtt tttttattta
    11521 tttacgtttt aaattaatgc cgatcgccgc tccgtttctg cttgaatcag ctacaccttt
    11581 aaaggtgccg ttttcatggt cgatcgatat gctttgcacg tttccgatat ccactggact
    11641 tgtgccgaat ttgtggccca tgccgtttag cttgctgagg acatctttag gaactccgtc
    11701 ttcgtaacgg taagagctca tgctgtttgt gtaaattctc ggctcttcaa cagctgcttt
    11761 taattccata ccatattcaa tgtggtagag aatggtttgc aaaacggatg aaataattgt
    11821 ggccccgcca ggagatccaa cagtgaggac aggcttgtca tccttaaata aaatcgtcgg
    11881 ggtcatgctg cttaaaggcc gtttgtttgg ctgtacttcg ttagctccgc ctggtatcgc
    11941 atcaaaatcc gttaattcat tgtttaaaat aacaccgtaa tcagggacca taataccggt
    12001 tccgaatagc tgttcgattg ttgttgtata ggaaacgaca tttccccaac ggtcagcaac
    12061 tgtaaagtgg gttgtttggc cttctacttt gtctttcggc tgttcaactt gtttatagtt
    12121 tgctgatcct tcttggtatt tccaagggtc accggctttc ggttttttat tcacttgatc
    12181 taggttgatt aattgctggc gttctttaat ataatcgggg tgaagcaagc ctttgagagg
    12241 aacatttaca aattcgggat cacctgcgta agacgcacgg tcggcataag acaaatgcat
    12301 cgtttcagca agcagctgat atttttccca tgagcggaca tcgtattgtg aaaggttaaa
    12361 atcatcaagg attttcagca tttgcaataa gaaaataccg ccggagcttg gaggaggagt
    12421 agtagcgatt tgatagcctt gatagtctcc ccaaatcggt tcatcaattg taatgtcgta
    12481 attttctaaa tctttttctg tcattgatcc gccgaaatcc tggacagtgt cagaaagcgt
    12541 cttggcgaat tttcctttat aaaaagcgtc agtgcctttg gagcgaataa gcttaaatgt
    12601 tttagccaaa ttcttttgaa taagggtatc tccttcttta agcggttcgc catttggtaa
    12661 aaatacatct tttgcggcag tccgtgaaag tttttcctga taatcagaaa tggcatctgc
    12721 caacacagaa tcaatcggaa agcctttttc agcgagttta atagaagggg taattaattg
    12781 cttcatcgaa cgggttcccc atttatccaa ggcttcttcc agccctttca gagtgcctgg
    12841 aacaccaacg gcagtacctt ttgttacacg ttcagagaaa ggtattgctt ttccgttttc
    12901 gtccagaaac atatcaggag ttgcgcctgc tggagcacgc tcacggctgt cgattatcgt
    12961 tgtatccttc gtttttccgt catacaccat cataaaaccg ccgccgccaa tacctgacat
    13021 catcggctct gttacattga gtgcaaattg aatggcaacc gctgcgtcaa tagcatttcc
    13081 tccttttttc agcacatcag caccgatttc agaagcaaga ggatgtgcgg tcgcaaccat
    13141 gccgtctttt ccaacatcta cttgtttgta ctcatcgtag cttttgggcg gttttttagc
    13201 ttccgcgtga aaagggacac ttccagcgac taacagaaca ctaagcagag ctgttaaaca
    13261 gacgttccac gttcttttca tgttctccct cctatatgaa gctgtattgt tacaatctta
    13321 gcgtaaaaaa attacagcgt tttcacaagt gacaaatggt atattatata gtacataaag
    13381 ccgtttttct gtgcaaaatt gattatattg atatgagcca tgtgctatat tagaatcagc
    13441 atacggatta agaagggact gctatatgta tttaacgatt gaagaaacag cagaatatac
    13501 aaatctttca gaggattata ttaaaagctt ggtgctcgaa gggaaaatca gagccgttca
    13561 tgacggggag caatttttga tttataagga acagttcaaa acgcatctcg aacagctgga
    13621 gaattacaaa gcactggtgc atgaaatatt aaatgaaccg atcccggaag atattgatgt
    13681 aaaggatgag gattaggaca caatttgaaa ttgtgtcttt ttttgtatat ttttgcggaa
    13741 gctccagaaa atcgggagtg tcagatttcg ttttaagagg ttttttgatg attagtaggg
    13801 ggataagtat ccaagaggtt aaaagcttta taagaggctt taaagcttat tttatagggt
    13861 gaaggttgga agaagctttt ttaaaagctt atgtaacact atgtatatta tgttacataa
    13921 acgccgccgc actttgacat tcaacgtttt tcagctataa tagtaacata gacctcaaaa
    13981 cgttacatga cggtttttaa ggagtttttt gatgcatatt gtacagccga ttcgcagtct
    14041 agagaaaatc caagaagtca aacagtattt acttaacaaa aacaagcggg attattttct
    14101 gtttattttc ggcatcaaca gcgcgcttcg catttctgat attctgccgc tgcaagtgaa
    14161 ggacgttcaa aataaagatc atttatgggc gactgaaagc aaaacgaaaa agaaaagaaa
    14221 gattcttatt ttagaatcgc tgaaacagga aatatacgag tatacgaaag acatgaagga
    14281 aaacgaatat ctttttaaat cagtgcggac caggaagccg atttcccgca ttcaggccta
    14341 cagaatttta agagaggccg ctgcggcgtg cggacttgag gagataggga cgcatacact
    14401 ccggaaaacg tttggctatc atttttatca gcgaacgaaa gacatcgccg agctgcagag
    14461 aatactgaat cattcatcac catcaattac aatgcggtat atcggtattg atgaagatac
    14521 aactagagcc gcatataagg tttttggagg actttaatac aaatcgcttg aaaatattga
    14581 tcatcagagc tactatataa ataccaaaag ctctagtagc acagcggata gtgcagcagt
    14641 ttcctaaact gcaggtcggg agttcgaatc tctcctagag cgttatattc acaaaaagac
    14701 aacaggcact tttcgcctgt tgtctttctt tatgcagacc aaataaaaaa cgcccgctta
    14761 taccgggcgt ttttcttata taactgcgtc aaattgattg actttccatt ttttattttc
    14821 tttcacgaat gtcactttcc gttttgcaga aggggatccg tctaatgtag gaacggtaaa
    14881 ttcgtatgtg attgtgctgc cttttttaga gatcagttta gcagttgatt ttttccaatt
    14941 caaaagattg tctccgtcac cgattggaac agcaagtttt ccttttgaaa cagtgaaatg
    15001 ataatcttta aagccttttt cgattgctgt ttttgtaaaa ataggagtta agtaattcac
    15061 cgcttttgct ttagtgccta gatcactgca catgtataca tattgaagat tttgatactc
    15121 gaatgtgcct gatgggcaaa ctgctttttt caccttcgga ttgtggccgc tcatggtgtt
    15181 ccaaaaatgt tctctagcgg ataatgccaa ctgtaatgct tgtttttgtg ataaatcgcc
    15241 tgatgtattt ttcgcaaatg catttgtgct taatgacaga ataagtgcaa tggttgttag
    15301 aaatagaaga cattttttca ttatcgctct ctccttcaaa atctctttct cttatgttac
    15361 aaatgttaca ataattacgg atagattaca atacttttgc ataaattatt ttttattctt
    15421 ttactcacaa aaaatatgcc attacttgct agtttattct ttataagcta aaaagatgtg
    15481 taaaattaga agaatcggga agggtttcat atgtgcagtg atgaataata acatgttaca
    15541 tatcctgttt ttgtcaaaaa atgagggcat gtttaaaaac gatttcaaat aaaggagtcc
    15601 tttaatatgg aaacatcaca agaacctctt gtaactcaaa agaaaagcaa accatcagtt
    15661 tggcggtcga tgtcactctt tttagtgccg cttctgctga gcaatgtgct gcaatcagtc
    15721 ggccagctag tcgggatgat ggctgtaggc agatggcttg gtgttgatgc agtggcagct
    15781 gtatcatcct ttttcccgtt attttttctt ttaatctcat ttacgattgg gatcggttca
    15841 ggtagttcga ttctgatcgg acaagcttac ggagcgaaaa atgaggaacg gctaaaggct
    15901 gttgtcggga cgacgctcac gtttacattt ttattaggcg ttgtgttagc cgtcatcggc
    15961 agtattttca ccctggatat ccttcgttta atgggcacgc ctgaaaatgt cattcatgtc
    16021 agcgctaact atgcacgtat tttattttat gctatgccgt ttatgttttt atattttgca
    16081 tatactacct ttttgcgcgg aacaggggat tctaagacac cgttttatac gctgattgtg
    16141 agcacggtca tcaacatcgc gcttttgcct gttttaatcc ttggcatgtt tggttttccg
    16201 aaactgggca tatacggctc ggcatatgca actgtcattt ccacgattgc gacttttctc
    16261 gtgttaatgg tgtatttacg aaagcgaaaa cacccgctgc aatttgataa aacagtgcgt
    16321 cgttatttga aaatggataa ggaactgctg gttctcctgc tgcgtcttgg ggtcccagca
    16381 agcatcaata tgattcttgt ctcattatca gagatagcgg ttatttcatt cgtcaatcat
    16441 tacggctcta atgcaacagc tgcatacgga gtggtcaacc aggtggccag ctatgtacag
    16501 atgccggccg tcagccttgg tattgcggtt tctattttcg ctgcgcaatc gattggggca
    16561 aacgagtttg accgcttaaa gcaggtcatt cgcgtgggga tttggctgaa ttatatcatt
    16621 ggcggcgtac tgatcattct gatctatgtt ttttcacatc agattttatc gttattttta
    16681 accgagcaag agacgcttta cattgcacac cgtcttttga tgattacatt gtggagctat
    16741 ttgctgtttg gaaatgccca aattatttct gcaacgatgc gggcaagcgg aacagtttta
    16801 tggccgaccg tcatcagtat ttttgcaatc tggggagtag aggtgcctgt cgctttcgtc
    16861 ctttctcact atacaaagct tgaaatactc ggcgtctggg ttggttatcc agctgcgttt
    16921 gccgtcagct tgctgttgat ttatgggtat tatcaattcg tctggaaaaa gaaacaaatc
    16981 acacgtctca tccaatagcc tccgaatcac accgttcata agtttgaacg gtgttttttt
    17041 atttgatagg ggaaaatata aaatggagga aatatggcac agtacattga attcttatac
    17101 tagcaatgaa tcaaggagag gttgagtaaa catggcaaac tttattgaga aaatcacgta
    17161 tttgggaacg ccggccatca aagcgggcaa cgaacatcta gaaatgattg ttgtccctga
    17221 gtgggggagc aacgtcattt ctctcgtgga caaaacaaca aatgtccagc ttttgcgtga
    17281 accggaaaca gcagaaagtt ttcacgacac accaacattg tatggcattc caatcctgtt
    17341 cccgcctaac cgcataggtg acggtacatt cagtttccgg ggcagaacgt atcattttga
    17401 tatcaacgag aaggataaac acaaccatct tcatgggttt ctttaccatg aaaagtggaa
    17461 tgtcgtgacc acgaagcaaa ctgatgaagg agtgattgtt gaaacagaaa ttgatctttc
    17521 tgagcttccc catgtgcaga atcaatttcc tcatcatgcc gtcgttcgga tgacatacac
    17581 gatcaagggg aataccctat ttaaacatgc gacggtcatg aacaaaggaa aggaagcgtt
    17641 tccttgggga attgggtatc atactacatt tgtgtttccg gcagaaagct cgttattctc
    17701 cctgacagca gatcagcaat gggagttgga tgaacgcctg ctgccgaccg ggaaactgat
    17761 ggatgtaccg aataaagaag ctttgcatga aggaatggat ttgcgccaca agcagctgga
    17821 tgatgtcttt ttatcttcct atcagaagag gggcggagaa aaccaggcag tcatttatca
    17881 tcaacatgca catatcagca ttatttataa ggcagatgaa cagtttaacc attgggttgt
    17941 atacaatgcg gacggaaaac aagggtattt atgccctgaa ccttacacat gggtgacaaa
    18001 cgctgtgaat cttgatttac cttcgtcact cactggttta caagtgctgg agccgggaga
    18061 agaaacgaca gctaaaagca gtatcaccat tgaactgaat catcaatagc caatgatgaa
    18121 gcgcagagag gcggggaaat gaatgaaaaa aagcataaag ctttatgttg ctgttttact
    18181 gcttttcgtt gttgcttcgg tgccttatat gcatcaggct gcgcttgccg ctgaaaaaca
    18241 agatgcactt tccgagcaga tcgataagat tttagctgat cattctgccc tcgaaggcgc
    18301 aatggccggc atcaccgttc gctctgcgga aacaggtgct gttctatatg aacattcagg
    18361 agacacccga atgaggcctg cctcttctct aaagcttttg acagcggccg cggcactttc
    18421 tgtccttggc gagaactatt cttttacaac cgaggtccgg acggatggaa cactgaaagg
    18481 gaaaaagctg aatggtaacc tttatttgaa agggaaaggc gatccgacac ttttaccatc
    18541 tgattttgac aaaatggctg agaaattgaa acattccggc gtaaaagtaa ttaaaggcaa
    18601 tctgatcggt gatgatacgt ggcatgatga catgcgatta tcacctgata tgccttggag
    18661 cgatgaatac acatattatg gcgcgccaat ctccgctcta acagcgtctc caaacgaaga
    18721 ctatgatgca ggcactgtga ttgttgaggt caccccaaat caaaaagaag gggaagagcc
    18781 tgccgtgtct gtctctccga aaaccgatta tataacgata aagaacgatg ctaaaacgac
    18841 tgctgccggt tcagagaaag acctcacaat cgaaagagag catggaacaa acacgattac
    18901 aattgaaggg agcgtaccgg ttgacgcaaa caagacaaag gaatggattt ctgtctggga
    18961 gcctgccgga tatgccttag atttatttaa gcagtcacta aaaaaacaag gtattactgt
    19021 gaaaggggac atcaagacgg gtgaagcacc tagttcttca gatgtgctgc tctctcatcg
    19081 ctcaatgcct ttatcgaaac tttttgtgcc gttcatgaaa ttaagtaata acggacatgc
    19141 cgaagtgctc gtaaaagaga tggggaaagt gaaaaaagga gaagggagct gggaaaaggg
    19201 gctcgaagtg ttaaacagta cgcttccgga atttggtgtt gattctaaat cactcgtctt
    19261 aagagacgga tcaggaatct cacatattga tgctgtatcc tcagatcaac tttcacagct
    19321 gttatatgac attcaggatc agagttggtt ctcggcttat ctaaattctt tacctgttgc
    19381 gggcaatcct gacagaatgg tgggcggaac gctgagaaac cgcatgaaag acactcctgc
    19441 acaaggaaaa gtaagagcaa aaaccggatc gctcagtacg gtaagctctc tatcggggta
    19501 cgcagaaaca aagagcggaa aaaaacttgt tttctctatt cttctaaatg gattgattga
    19561 tgaagaggat ggaaaagata ttgaggatca aatcgctgtc attttggcaa atcaataata
    19621 gcggcagacc tgttttccaa gagaaaacag gtttttttta tgtctgtaat aacgctttgt
    19681 cgaaccttcc aacaattaga agaatcatgc acaaaagaaa attagtccga ttaaaaagta
    19741 gtgtataaga ccttatgtaa aacaatactt ttatcacttt atatccggaa atttgataaa
    19801 aaaagaaacg aaaaataaag aaataatact atattcaaaa aaatgttata aaaatttaat
    19861 gttttttatt gtactttaaa aaatatccgt taatatagtg catatatgga ttatatagtc
    19921 atataatttc ttttattgac atttttctgc ttttttctac tttttcttat cctcttatta
    19981 tgagaactgg agggaatccg ttgagcgaac atacttattc tttaacccat gcccaaagga
    20041 gagtgtggtt tactgaactg ctggagccag ataccagcat ttgcaatctc acagcctgtg
    20101 tgaaattcaa aggcaatatt gagcttcata ctctcgaggg agcgctgaat cattccatct
    20161 cccgcaacga cgccattaga tttcagctgt tagaaggaga agagcttgag ccgcgattgc
    20221 accttactga atataaatat tatccactta gaataattga tttttcaaat gttgaaatga
    20281 tagaaataga gcaatggatt caggatcaag cgagcattcc atttaaactg ttcaactcgc
    20341 ctctttatca attttacctc cttagaattg actctcatga agtttggcta tttgcgaaat
    20401 tccatcatat cataatggat ggaatctctt taaatgtgat gggaaatcaa attatagatc
    20461 tttatcaaaa aatgaaaaag aaagatcctt tacctgatca gccggaacct tcttacttga
    20521 gttacatcga aaaagagagt caatatctac aatctccgcg gtttgcaaag gaccgtttat
    20581 tttggacgca aacctttgag cacccgttgg aataccactc gttagccgac cagacgtcct
    20641 tacaaaaaca gagcacttct gcatccagag acaccatcat tctttcacct gatttagagc
    20701 aaacgattcg aatcttctgc gaagaacaca agatcaatat catttcctta tttatggctt
    20761 cattttacat atgcatcagc cgaatcactt ctaaaaaaga tcttgccatt ggcacctact
    20821 atggcaacag agggtcaaag gctgaaaaag aaatgctcgg catgttcgtt agttctcttc
    20881 caatcagaat aacggttgat cctgacacag attttctttc ctttgtccgc acaataggca
    20941 gggaacagct ttctgttatg cgtcatcaac ggtttcctta taatttgctt gtaaatgaat
    21001 taagaaatga acagaaggat ttacacaacc ttatcggtat atctatgcag tatcagccac
    21061 ttcagtggca taatgcagat gattttgact atgaaacagc gctttatttc agcggataca
    21121 ccgcgaacga gctttcagtt caaatacaag aacggataga caatggaacc attcaattaa
    21181 atttcgacta tcaaaatacc ttgttttctc ttgaggatat taaacgaata caatctcatc
    21241 tgcttaccat actggaaaac gcccttcaac atccgcacag ctttataaga gaattagata
    21301 tgacgaatac aagagaaaag caaaaattgt tgtatgagtt taacaagacg gaagctgttt
    21361 cgcctaaagc tttcaccctg catgggctgt ttgagcgaca ggcagctttc acaccggagc
    21421 ggctggccat tcgcttttca ggcggttcgc tgacatacgc tgagcttgat atgtacgcca
    21481 gccggctggc tgcgcacctt gcggcacgcg gcgtctcaaa cgaaagtatc gtcggtgtcc
    21541 tgtctgaacg ctcacctgac atgctgatcg ctgtccttgc tgtactgaag gccggcgggg
    21601 cgtatttgcc gcttgatcct gcgtatccaa aggagcggct gagctacatg ctgaaagaca
    21661 gcggggcatc gctcttgctg acacagccgg gatgctccgc accgaacttt tctggcgaaa
    21721 cgcttgaagt ggacatgaca tctcttgcga gagaaaaagc agaaaaccat ctgtttactc
    21781 ctgctgacgg cggttctctc gcctatgtca tctatacatc ggggtctacc gggcagccga
    21841 aaggagtggc cgttgagcac cgccaagctg tttcctttct gaccggcatg cagcaccagt
    21901 ttccgctttc agaagatgac attgtcatgg tgaaaacctc tttttccttt gatgcgtctg
    21961 tgtggcagct gttttggtgg gctctttccg gtgcttcggc gtatctgctt ccgcccggct
    22021 gggaaaaaga ctccgcattg atcgtaaaag ccattcatca ggaaaaagtg acaacggctc
    22081 attttattcc ggctatgctg aatagctttc tggatcaagc agaaatgtt
//
