LOCUS       NZ_NJRD01000003        26226 bp    DNA     linear   CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain 20-3 20-3_R1_(paired)_contig_3, whole
            genome shotgun sequence.
ACCESSION   NZ_NJRD01000003
VERSION     NZ_NJRD01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 1055472)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1055472)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010578135.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:42:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,274
            CDSs (total)                      :: 4,198
            Genes (coding)                    :: 4,064
            CDSs (with protein)               :: 4,064
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1 (5S, 16S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 1 (5S, 16S)
            tRNAs                             :: 67
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 80 of 134
            Pseudo Genes (incomplete)         :: 67 of 134
            Pseudo Genes (internal stop)      :: 22 of 134
            Pseudo Genes (multiple problems)  :: 31 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 280266
            Orig. end                         :: 306492
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NJRD01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26226
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26226
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26226
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16226](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16226)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            118..888
                     /gene="yvaM"
                     /locus_tag="CE053_RS07140"
     CDS             118..888
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-128). E-value:
                     4.7e-18. Score: 57.6. Matches aSDomain:
                     nrpspksdomains_CE053_RS07140_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="yvaM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391244.1"
                     /locus_tag="CE053_RS07140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_163182229.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.8e-13, bitscore:
                     46.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.5e-14, bitscore: 48.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKFFYYQRLLSKH
                     FRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHIGF
                     TRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLRSIL
                     TDHMKKADQAHWHQYYLDSLGYNCIEQLPRLDMPMLFMYGGLRDWTFTNAGYYRRSCRH
                     AEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS"
     aSDomain        181..501
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE053_RS07140_Abhydrolase_1.1"
                     /evalue="4.70E-18"
                     /label="CE053_RS07140_Abhydrolase_1.1"
                     /locus_tag="CE053_RS07140"
                     /protein_end="128"
                     /protein_start="21"
                     /score="57.6"
                     /tool="antismash"
                     /translation="PIIFIHPPGMGRKFFYYQRLLSKHFRVIFPDLSGHGDSDHIDQPA
                     SISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHIGFTRPDKVSHLILSGAYPAVHNV
                     IGQ"
     CDS_motif       379..420
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE053_RS07140_0001"
                     /evalue="3.60E-04"
                     /label="NRPS-te1"
                     /locus_tag="CE053_RS07140"
                     /protein_end="101"
                     /protein_start="87"
                     /score="13.1"
                     /tool="antismash"
                     /translation="VLFGYSAGGLIAQH"
     gene            complement(928..1161)
                     /gene="yvzC"
                     /locus_tag="CE053_RS07145"
     CDS             complement(928..1161)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="yvzC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391245.1"
                     /locus_tag="CE053_RS07145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_003220031.1"
                     /transl_table=11
                     /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNGE
                     RRPGQLVIGKMLHYFNLKFEDLFYYDFIDKSQ"
     gene            1313..1720
                     /gene="rghR"
                     /locus_tag="CE053_RS07150"
     CDS             1313..1720
                     /codon_start=1
                     /gene="rghR"
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391246.1"
                     /locus_tag="CE053_RS07150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcriptional repressor RghR"
                     /protein_id="WP_003220034.1"
                     /transl_table=11
                     /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVPK
                     PATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLENE
                     KWQYLNKEDLLMLDHYFSFISDEAKKRSADD"
     gene            1750..2169
                     /gene="rghRB"
                     /locus_tag="CE053_RS07155"
     CDS             1750..2169
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="rghRB"
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391247.1"
                     /locus_tag="CE053_RS07155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_014480905.1"
                     /transl_table=11
                     /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTPK
                     PATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASESYQSVYEIYQTAVTRGAEHLPI
                     FNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS"
     gene            2261..2587
                     /gene="catR"
                     /locus_tag="CE053_RS07160"
     CDS             2261..2587
                     /codon_start=1
                     /gene="catR"
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391248.2"
                     /locus_tag="CE053_RS07160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="catDE operon transcriptional regulator CatR"
                     /protein_id="WP_003242888.1"
                     /transl_table=11
                     /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALPN
                     LSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWIDP
                     SFLD"
     gene            2715..4415
                     /gene="yvaQ"
                     /locus_tag="CE053_RS07165"
     CDS             2715..4415
                     /codon_start=1
                     /gene="yvaQ"
                     /gene_functions="other (smcogs) SMCOG1061: methyl-accepting
                     chemotaxis protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391249.1"
                     /locus_tag="CE053_RS07165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyl-accepting chemotaxis protein"
                     /protein_id="WP_038829369.1"
                     /transl_table=11
                     /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTKW
                     IDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKTIS
                     TDKEQKLFEQLQTEVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTITQLV
                     DLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMKESAN
                     HIAEGDLSNDMEPLNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQVLATAT
                     NETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITISDTSQNV
                     LELAVSGNENMATSLQQMKTIHHIVEKAVHKVRSLEQHSQDINKLVQVINGIAEQTNLL
                     SLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVGGTQQEIHTVITYLES
                     SFTEVEKGTENLTDTGQAMRHIKQSVTHVADSIKEVTDGLKQLTNQSITINQSIENIAS
                     VSEESAAGIEETFSITEQSAHSMDQVLQNAEELEQLAKELNEKMGQFTI"
     gene            complement(4446..5828)
                     /locus_tag="CE053_RS07170"
     CDS             complement(4446..5828)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019715739.1"
                     /locus_tag="CE053_RS07170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="WP_032726857.1"
                     /transl_table=11
                     /translation="MGIGFKGQKTLLRELIKYMVTLCISLVVLALLYLFINTIAMNTGF
                     SHPANYNEREAEKLAPKLENTDKVTADMIPDTMSYAILDKETKQKTAGTIKEKDLQLVK
                     KKIEKKPYVNYKQKGYLVIDRNEEYCILQYSLRADFSSPLLRKYLPNYELTSICILIVL
                     LIVVISIITTYFANRLRKHFETLNVITRYIKEQNLQFTPEFTHIKEFDDVIDSLIEMRD
                     ALRSSLEAQWRLEKNKKEQIGALAHDIKIPITIIKGNAELLSLSIQNEEQAEYTKYILG
                     AGNQIEQYISQLIHLSRTEDSLTIHLEKAFVDKLTETLQKDISAYKGNKKINISFKKEN
                     LKKEAEIDWQLLHRALLNILTNAVDYTPEDGTVSVHAECDSDTFYFFVKDTGNGFSEIG
                     LKKATELFYMDDKARQSKGHYGMGLTFAKNAVNLHNGELTLGNTIEGGGEVRVKIPLYR
                     NH"
     gene            complement(5819..6481)
                     /locus_tag="CE053_RS07175"
     CDS             complement(5819..6481)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016937907.1"
                     /locus_tag="CE053_RS07175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_032726858.1"
                     /transl_table=11
                     /translation="MAKILAVDDEKDILVLIQNILRRDQHQVDILDRVKGQPPDVFQGY
                     DLILLDVMMPDIDGFELCKQIRPLVDCPILFLTAKTEEEAIVKGLITGGDDYITKPFGV
                     RELSARVNAHLRRERRDKHQSKRVISGFLFHFDSKEVFINNHKLNLTKNEYKICEFLAQ
                     HKGRTFSREQIYEEIYGLEGNALYSTITEFIRTIRKKCKEHNTDPIKTVWGVGYKWE"
     misc_feature    complement(6458..6472)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(6499..7263)
                     /locus_tag="CE053_RS07180"
     CDS             complement(6499..7263)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019715741.1"
                     /locus_tag="CE053_RS07180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_038829371.1"
                     /transl_table=11
                     /translation="MRLLLRCLKADFQKSKHTSFMWLHLIIPIAFSTVLILYFYERDQS
                     QFHLYKSFMEAIAVALPLLIGVLCGMTASLEEQAGKFQVLLGSTSPKVIAYASKMLMLL
                     FMELCSIGIALFIYIIGLKFILHVPDLSYDIFITGGAWLVAGSVALYCIYFFISCMFGM
                     GASVLIGGAGLLMTALMNTGLGDAIWKYNPWAWGIRLSGLNGVLHFKEKGDNPLLMHEI
                     NSGVLVMIFGIICIIVASLIWFSKWEGRKTFE"
     gene            complement(7265..8020)
                     /locus_tag="CE053_RS07185"
     CDS             complement(7265..8020)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019715742.1"
                     /locus_tag="CE053_RS07185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_041850531.1"
                     /transl_table=11
                     /translation="MMNYMKAENLKFKRTFSRKMIILVPLLNIGFSFLMNIQFFVPGTF
                     NWWSIIFMPVMIALFCSLSHQKEKKASNYNGTYSLPIDLGRLWYSKIVIIMIYSLLSQI
                     VFLVFMLLMGFVIADFAIVTLSAIAASLLLWVTSLWQIPLCLFVAKKWGLTIAVMLNLI
                     GTLVLGIMPASRSFWWFIPWSWPIRMMCPTIGIHPNGLLLEKNDPLLSWMVVPPAILIS
                     ILLFLIIAFLTSRSFAPSIDYRTKKQGAI"
     gene            complement(8017..8733)
                     /locus_tag="CE053_RS07190"
     CDS             complement(8017..8733)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007409980.1"
                     /locus_tag="CE053_RS07190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_038829373.1"
                     /transl_table=11
                     /translation="MSTVLLETKSLTKKFGKETAVSDVSLTVQKNSIYGLLGPNGAGKS
                     TTLKILTGILRKTSGEVFFDGHKWKRSDLQNIGSLIEAPPLYDNLTAFENVKVHATLLG
                     LSEDRINSVLKTVDMQHAGKKRAGQFSMGMRQRLGIAIALLNHPKLLILDEPTNGLDPI
                     GIQELRDLIRSFPQEGITVILSSHILSEVEQIADHIGIIIGGHLGYQGEINKTDDLEHL
                     FMEVVKASREKEGVKR"
     gene            complement(8747..9238)
                     /locus_tag="CE053_RS07195"
     CDS             complement(8747..9238)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003220043.1"
                     /locus_tag="CE053_RS07195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_097080580.1"
                     /transl_table=11
                     /translation="MFLKRCVNISGCFIVLFMLSACQALTKFKDKTVEETKKTVHFTED
                     NNETSETMESLIDKGKLDQVVYNENLYQMKDKVDEDKKGKVIGAIGQTFFVDSEGKRWS
                     EEELKEPYISNDPDETREKKPLRYGKVYSANEDTDAKDEIIVEFNREYYRAVLIKNEKG
                     "
     gene            complement(9757..9927)
                     /locus_tag="CE053_RS07200"
     CDS             complement(9757..9927)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="CE053_RS07200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_032726862.1"
                     /sec_met_domain="TIGR03731 (E-value: 7.2e-23, bitscore:
                     76.4, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 2.4e-06, bitscore:
                     22.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKFDDFDLDVVKVSKQDSKITPQWKSESLCTPGCVTGVLQTCFL
                     QTITCNCKISK"
     CDS_motif       complement(9856..9927)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSKFDDFDLDVVKVSKQDSKITPQ"
                     /locus_tag="CE053_RS07200_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9757..9855)
                     /prepeptide="core"
                     /locus_tag="CE053_RS07200_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="27.80"
                     /molecular_weight="3349.0"
                     /monoisotopic_mass="3346.7"
                     /core_sequence="WKSESLCTPGCVTGVLQTCFLQTITCNCKISK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSKFDDFDLDVVKVSKQDSKITPQ"
                     /leader_location="[9855:9927](-)"
                     /alternative_weights="3367.0"
                     /alternative_weights="3385.0"
                     /alternative_weights="3403.0"
     misc_feature    complement(9993..10006)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            complement(10001..11326)
                     /locus_tag="CE053_RS07205"
     CDS             complement(10001..11326)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014115182.1"
                     /locus_tag="CE053_RS07205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_085185756.1"
                     /sec_met_domain="LANC_like (E-value: 9.6e-88, bitscore:
                     290.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRGAVSGIEVELVKEIARQVSNYDKVLEIVNKKDNFLSIGEVPL
                     IPWKPTALSHGIPGICMLYGELHAHFPEEGWDDLGHKYLSILVNEIKEKGLHTPSMFSG
                     AAGIGLAAVCLSQHFTYYKGFISRINEYLAEVVPQLLTEFSQREVYMSDYDVIEGVSGI
                     ASYLLLFQEDKAMKDLLIDILRYLVRLTEDITMNGEKVPGWHIPSENQFTDIEKKAYPN
                     GNFNMGLAHGIPGPICILSSALMQGIKVKGQESAIEKMVDFLLEFSEKDQGNLFWKGNI
                     SFEEYQYGSPPKALNFSRDAWCYGRPGVCLAIVKAGKALQNTRFLNIGVQNLRCTASDI
                     QGIFSPTICHGYCGISQILLAVNQLTGQEFFNEELQKIKQKIMSYYDKDYIFGFHNYES
                     IEGNEAVPLQYVGLLDGAVGVGLGLLNMELGSKTDWTKALLI"
     gene            complement(11299..13143)
                     /locus_tag="CE053_RS07210"
     CDS             complement(11299..13143)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014115183.1"
                     /locus_tag="CE053_RS07210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_163182230.1"
                     /transl_table=11
                     /translation="MEVKEQLKLKELLFIMKQMPKTIKLIFTLERSLFLKLILFSIITG
                     ILPIVSLYISQELINSLVTIRKDVSVVISIFLTYLGVSFCSELISQVSEYYNGKFQLNI
                     GYKLNYKVMKKSSNLALKDFENPEIYDKLERVTKEISYKPYQIIQAIITMTTSFVTLLS
                     SIAFLMSWNPKVSLLLLVIPVISLFYFLKIGQQEFFIHWKRAGQERKSWYISYILTHDF
                     SFKELKLYNLKDYLLNKYWDIKKSFIDQDTKILRKKTYLNLIYEIAVQLVGAVIIFIAI
                     MSAFAGKIMVGNVMSYIRSVSLVQSHSQSIMTSIYSIYNSNLYMNQLYEFLELKEEKNQ
                     GHKKQIVEPIHSVIFQNVSFIYPNQGEQTLNHINVSLNKGERIAIVGPNGSGKSTFIKL
                     LTGLYEVQQGDILVNGVNIKELDMDSYMEQIAALFQDFMKYEMTLKENIGFGQIDKLHQ
                     TNKMHEVLDIVKADFLKGHSSYQFDTQLGLWFDEGRQLSGGQWQKIALARAYFREASLY
                     ILDEPSSALDPIAEKETFDTFFSLSKDKIGIFISHRLVAAKLADRIIVMDKGEIVGIGT
                     HEELLKTCPLYKKMDESENYMNPLEEDGTKWEEALYQG"
     gene            complement(13134..16226)
                     /locus_tag="CE053_RS07215"
                     /pseudo=""
     CDS             complement(13134..16226)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="CE053_RS07215"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /pseudo=""
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.9e-125,
                     bitscore: 414.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6e-13,
                     bitscore: 45.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-25, bitscore:
                     86.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSLYTPTDYYMIRVPLVHQALKNENSQDTDQLLHDLCNDSLFRE
                     QILVSSRTLYDTMNIFLQTPDKLKGKKKRNFQQAILKYATRRATRTTPFGLFSSVGIGA
                     FSDKNQLSFNQHSFYKKARVDFEWLYQLTRKLENEYIDRLSFTLNPACYIKGDRAYLLY
                     STDGKSEEVSVRATSVFHLINELCGECVAYHDIIRSLTENYENTPISKINQYVADLIDK
                     EFLISNLRPPMTVSDQFQYLIAQAESSRIPNELLQACRKIQYQIDEYNRITIGEGEDQY
                     LNLIETMNELIKTSSPLQVDTGLGDSSIQLDNETSLAISELASMFTYMAAPSAERLDHL
                     EKYKNVFLERYGYEREVPLLEMLCSNAGIGAPATYTNPVNEFFEEISFEDQFSPEMKQF
                     FMKKYFESVRKKAPIQLHDETFHRICNYEIADEEIPVSFELNFFVKLRNGRVMLYLGPN
                     VGSTRAGKTFGRFTHLSDSINAVVKKIHNKEKELTSKNKKICELSIVPNQVRSGNVTRN
                     VSYREKEMNLFTNSVLHHNDSVKAEDVLIGIDKKHIFYAKHKCTGEILSFESNHMFNPL
                     LMPNVLRFLLEISRDGKRKWNDFPWMGIYSDFKYIPEIKYKEIILSCEQWLIHKSDLSI
                     HSNSSIDEVKSAFFEFHRTYDLPQRFYIVNADNRLLIDIEDDRTLDVFFWELKKTNHNH
                     PLQLVAAELDANALKDKNQNVYSGEIVVPLIRKKPEKPLKLPVLNSVEENRSERIKMPF
                     EDWLFIKLYCKQTREEELIAFEIADFYNQISDQYPVRHFFMRYRDPKPHIRLRLNGKAE
                     VLYSLFPQLLNWLKSLREKGLVTEFVITQYEREIERYGGLDLMDAAEQVFCEDSKVVET
                     MIRMHRMKDIAISKEIAGMVSVIQFLEQFELTFEEQLTFL"
     aSDomain        complement(15531..15788)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CE053_RS07215_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.60E-14"
                     /identifier="RREFam001.1"
                     /label="CE053_RS07215"
                     /locus_tag="CE053_RS07215"
                     /protein_end="232"
                     /protein_start="146"
                     /score="45.4"
                     /tool="antismash"
                     /translation="TLNPACYIKGDRAYLLYSTDGKSEEVSVRATSVFHLINELCGECV
                     AYHDIIRSLTENYENTPISKINQYVADLIDKEFLISNLRPP"
     misc_feature    complement(16321..16335)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.28"
                     /tool="antismash"
     gene            complement(16440..17117)
                     /gene="opuBD"
                     /locus_tag="CE053_RS07220"
     CDS             complement(16440..17117)
                     /codon_start=1
                     /gene="opuBD"
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003235180.1"
                     /locus_tag="CE053_RS07220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="choline ABC transporter permease OpuBD"
                     /protein_id="WP_032726866.1"
                     /transl_table=11
                     /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAGI
                     LIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRNTY
                     TGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGTFVG
                     AGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWIERLLNPVKQKNRRKLIR
                     VSS"
     gene            complement(17134..18054)
                     /gene="opuBC"
                     /locus_tag="CE053_RS07225"
     CDS             complement(17134..18054)
                     /codon_start=1
                     /gene="opuBC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391251.1"
                     /locus_tag="CE053_RS07225"
                     /note="OpuBC (osmoprotectant uptake transporter system
                     OpuB, component C), as studied in Bacillus subtilis, is a
                     lipoprotein, and is the substrate-binding protein of an
                     ABC-type high-affinity transporter. OpuB is closely related
                     to OpuC, which acts on both choline and the betaine
                     (trimethylated amino group form) of glycine; OpuBC is
                     nearly 70 percent identical to OpuCC; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="choline ABC transporter substrate-binding
                     lipoprotein OpuBC"
                     /protein_id="WP_163182231.1"
                     /transl_table=11
                     /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMSE
                     SEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNDEIDIAATRYTGDALTGTLRM
                     EPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVKKWA
                     PQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKNGKMDIVLAYSTD
                     GRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATMQELNY
                     EVDGNLKEPSVVAKEYLEKHHYFES"
     gene            complement(18066..18719)
                     /gene="opuBB"
                     /locus_tag="CE053_RS07230"
     CDS             complement(18066..18719)
                     /codon_start=1
                     /gene="opuBB"
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391252.1"
                     /locus_tag="CE053_RS07230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="choline ABC transporter permease OpuBB"
                     /protein_id="WP_003228370.1"
                     /transl_table=11
                     /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVLT
                     RMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYTGI
                     RGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIGGGG
                     LGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS"
     gene            complement(18736..19881)
                     /gene="opuBA"
                     /locus_tag="CE053_RS07235"
     CDS             complement(18736..19881)
                     /codon_start=1
                     /gene="opuBA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391253.1"
                     /locus_tag="CE053_RS07235"
                     /note="OpuBA (osmoprotectant uptake transporter system
                     OpuB, component A) is the ATP-binding subunit of the ABC
                     transporter OpuB, one of several involved in the uptake of
                     osmoprotectants (compatible solutes) such as choline,
                     proline, and glycine betaine, in the endospore-forming
                     model bacterium Bacillus subtilis. Note that three out of
                     four subunits of OpuB are quite similar to those of OpuC;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="choline ABC transporter ATP-binding protein
                     OpuBA"
                     /protein_id="WP_163182232.1"
                     /transl_table=11
                     /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTTM
                     KMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPKLL
                     KWPEQQRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMDEPF
                     GALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVGTPDD
                     ILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLMRQERV
                     DSLLVVDDEHVLQGYVDVEIIDQCRKKANLIGEVLHEDIYTVLGGTLLRDTVRKILKRG
                     VKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS"
     misc_feature    19932..19946
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 26.32"
                     /tool="antismash"
     gene            20165..20698
                     /gene="yvaV"
                     /locus_tag="CE053_RS07240"
     CDS             20165..20698
                     /codon_start=1
                     /gene="yvaV"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391254.2"
                     /locus_tag="CE053_RS07240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GbsR/MarR family transcriptional regulator"
                     /protein_id="WP_014478002.1"
                     /transl_table=11
                     /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNRK
                     PMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITLFS
                     ATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSRLIE
                     FFESEEIFKYVPKP"
     gene            complement(20730..21404)
                     /gene="opuCD"
                     /locus_tag="CE053_RS07245"
     CDS             complement(20730..21404)
                     /codon_start=1
                     /gene="opuCD"
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391250.1"
                     /locus_tag="CE053_RS07245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycine betaine/carnitine/choline/choline sulfate
                     ABC transporter permease OpuCD"
                     /protein_id="WP_014478003.1"
                     /transl_table=11
                     /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLGI
                     LIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRNTY
                     TGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGTFVG
                     AGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKRKKKNLAG
                     AA"
     gene            complement(21422..22333)
                     /gene="opuCC"
                     /locus_tag="CE053_RS07250"
     CDS             complement(21422..22333)
                     /codon_start=1
                     /gene="opuCC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391261.1"
                     /locus_tag="CE053_RS07250"
                     /note="OpuCC (osmoprotectant uptake transporter system
                     OpuB, component C), as studied in Bacillus subtilis, is a
                     lipoprotein, and is the substrate-binding protein of an
                     ABC-type high-affinity transporter for both choline and
                     betaine. OpuC is closely related to OpuB, which acts on
                     choline; OpuCC is nearly 70 percent identical to OpuBC;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="osmoprotectant ABC transporter substrate-binding
                     lipoprotein OpuCC"
                     /protein_id="WP_072175116.1"
                     /transl_table=11
                     /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTESE
                     ILANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGKEA
                     EKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKNASQ
                     YKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYSTDGR
                     IKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQELNYEV
                     DGKLKEPSVVAKEFLEKHHYFD"
     gene            complement(22353..23006)
                     /gene="opuCB"
                     /locus_tag="CE053_RS07255"
     CDS             complement(22353..23006)
                     /codon_start=1
                     /gene="opuCB"
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391262.1"
                     /locus_tag="CE053_RS07255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycine betaine/carnitine/choline/choline sulfate
                     ABC transporter permease OpuCB"
                     /protein_id="WP_003228349.1"
                     /transl_table=11
                     /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVALT
                     RMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYTGI
                     KGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIGGGG
                     LGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS"
     gene            complement(23029..24171)
                     /gene="opuCA"
                     /locus_tag="CE053_RS07260"
     CDS             complement(23029..24171)
                     /codon_start=1
                     /gene="opuCA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391263.1"
                     /locus_tag="CE053_RS07260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="osmoprotectant ABC transporter ATP-binding
                     protein OpuCA"
                     /protein_id="WP_003243370.1"
                     /transl_table=11
                     /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTTM
                     KMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPKLL
                     KWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMDEPF
                     GALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVGTPDE
                     ILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMREKRVD
                     SLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRKILKQGI
                     KYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI"
     misc_feature    complement(24199..24213)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 25.92"
                     /tool="antismash"
     gene            24435..24992
                     /gene="opcR"
                     /gene_synonym="yvbF"
                     /locus_tag="CE053_RS07265"
     CDS             24435..24992
                     /codon_start=1
                     /gene="opcR"
                     /gene_synonym="yvbF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391264.1"
                     /locus_tag="CE053_RS07265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="opuC operon transcriptional regulator OpcR"
                     /protein_id="WP_003228345.1"
                     /transl_table=11
                     /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNRK
                     PMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISLFA
                     ANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLSRLI
                     EFFESEEVFRYVPKTKESSSLK"
     gene            complement(25010..25645)
                     /gene="yvbG"
                     /locus_tag="CE053_RS07270"
     CDS             complement(25010..25645)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /gene="yvbG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391265.1"
                     /locus_tag="CE053_RS07270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAAT family transporter"
                     /protein_id="WP_010886614.1"
                     /transl_table=11
                     /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARKA
                     AILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHHDE
                     HKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALTFLF
                     FHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS"
ORIGIN
        1 acttctattt tacatgaaaa gggttggcat gtcacgctgt atcagacgcc aaaaggccgg
       61 ataagacgtt ttatcttggt taccctattc atatgaaaag gtcaaaggag aaaagcgatg
      121 ccgcttatca gcatagacag caggaaacat cttttttatg aagaatatgg acagggaatc
      181 cctatcattt ttatccaccc gccgggcatg ggacgcaagt ttttttatta tcagcgcctt
      241 ctatccaagc atttcagggt gatttttccc gatttaagcg gccacggtga tagtgatcac
      301 atcgatcagc cagcgtctat ttcctattac gcaaacgaga tcgcgcaatt catggacgct
      361 ttgcacattg ataaagctgt gttattcggg tattctgccg gaggcttaat cgcgcagcat
      421 atcggcttta cccgcccgga caaagtgtca caccttattc tgtccggcgc ctacccagct
      481 gttcataacg taatcggcca gaagctgcac aaactgggaa tgtatctgct tgaaaaaaac
      541 cccggtttgc tcatgaaaat cctcgctggc agccacacaa aagacagaca gcttcgcagc
      601 atattaacag accatatgaa aaaagcagac caggcccatt ggcatcagta ttatctggat
      661 tcgcttggct acaactgcat tgaacagctg ccccgcctag acatgccaat gctgtttatg
      721 tatggcggcc tgcgggactg gacctttacg aacgcaggct attaccgaag atcgtgcaga
      781 catgccgaat ttttcagatt ggaatatcag ggacatcaat tgccgacaaa acaatggaaa
      841 acgtgcaatg agctggtgac agggtttgtg ctgacacatc attcatagga atagaaaacg
      901 cttggcttcc ttgcgttttt tgttacttta ttgacttttg tcaataaagt catagtaaaa
      961 aagatcctca aatttcaaat taaaatagtg aagcatttta ccgatcacaa gctgccccgg
     1021 tcgtctttct ccattcagca cgcggctcag tgtggcgggt gagactccga tttccagcgc
     1081 aagctgatta agggaataat cgttattaac catatactgc aagacataat cacgtctaat
     1141 ctgtatcttt tctactggca ctttcctcac cttccattcc tgaaaaactt ttttctatac
     1201 ttttacatta cgtcttatgt taacttttgt caatacattt ccagtctacc tattcccttt
     1261 agtcaataaa catactaaaa tatgagtaac agtgagggac ggggtgagat atatggaaag
     1321 ctttggcgaa caattacggg cattgcgtga agagagaaag ttaacagtca accagctggc
     1381 gacttattca ggcgtaagcg cggccggcat ctccagaatc gaaaacggaa aacggggcgt
     1441 tcccaaacct gccaccatca aaaaactggc agaggcctta aaaattcctt atgaggggct
     1501 tatgtacaag gctggttaca tcgaagaagt gcatgaagcc agggcccctt atgaaacgaa
     1561 gtgcaagctg cttgaaaaag cggaggccta tgacctgaaa aaccttgcgc ttcttgagaa
     1621 cgaaaagtgg caatatctca ataaagaaga tttgctcatg ctggatcatt atttttcgtt
     1681 tatttcagac gaagccaaaa aacggtctgc tgatgactga ctcttgatag aaatgtgagg
     1741 cgatagacca tgtcaccgtt cggacagcaa ttacgggagc tgcgccgcgc ccgcaaactg
     1801 acagtgaatc agcttgcggt gtactcaggc atcagctcgg ccaccatttc aaaaattgaa
     1861 aacggcaaac gcgggacgcc aaaacccgcc acgattaaaa aactggcagc cgtcctgaaa
     1921 gtgccgtacg aaaacctaat ggccgccgca ggccatattc aggcctttcc tgaagaaatc
     1981 cgcgaagcat ctgaaagcta tcaatccgtt tatgaaattt accagacagc tgtcacgcgc
     2041 ggagcggagc acctcccgat tttcaatagt caaaaatggg aacatctctc aaagcaggat
     2101 attgaaaatc tcagcaaata cttcgatttt ttgtcttcag aagcaaaaaa acgcgcctct
     2161 tcctcataat cccctgtttc tctttctata ttttatcaat cacgcttgca taccctccct
     2221 cgttatttgc gttataatag tgacagacga ggtgaaaagt atgaaccaat cagaaatgtg
     2281 tcctagattt gaaaaagcag tcgacatctt aagtaaacgc tgggtcgctt taatcgtatt
     2341 tcagctcttg aacggatcgc agcgatttag cgaaattgaa gcagcacttc caaatctaag
     2401 cggcagagtt ctgtcagaac ggctgaaaga acttgagctt gaaggagtag tgaagcggga
     2461 tgtcatccct gaaactccgg ttcgcatcga atattcattg actgataaag gaaaggcact
     2521 ggcccccatt ctaggtgaga tttctaaatg ggcgactgaa tggattgacc cttcctttct
     2581 tgactaattg ctaaaacggt tctgatctca aagacgagaa aagagccgtt ttttattttt
     2641 ttccaggtga aaaaacgatt tctcagccga tatatagtac atccacacat tacgttttta
     2701 aaggagacca ctatatgcga ctgacgattt cccgcaaatt cagcctggta tttttgacac
     2761 tgatcctgat caatttactt gtaggcggaa taggcgttct taatatgcag catatcattc
     2821 aaaaaacaga tgaaatcaac acaaaatgga ttgacggcat caaaggaatc acttcaatta
     2881 attatgtaac cgagcacctg tcttctaaag aaaaggactt tctgatttat acagacaaaa
     2941 gcaaaatgga tacacttgat caagaaatga atcaaatcat ggaagacatt aaccaaaagc
     3001 tcgataacta cgaaaaaacg atctccactg ataaagagca gaaactgttc gagcagcttc
     3061 aaactgaagt gaatacctat atggatattc atgcgcaaat tatcgaaagc ggccgcacga
     3121 atgacatgga caaagcaaga ggtttattgg ttcagactga ggccagcttt gaggatatga
     3181 aaaaaacaat cactcagctt gttgacttaa atcaagaagg cagcaacaca gcggtaaaag
     3241 aaacgaaggc cgtctatcat aaagggctca tttacactgc tttgcttgtg gcagcatcga
     3301 tcctcatcag cattttcatc tggctttata tcacgcgaaa cattgtaaag cctatcattc
     3361 gcatgaagga atctgccaat catattgccg aaggcgatct gtcgaacgat atggagccgc
     3421 tcaactcaaa agacgagctg ggtgatctga atgaagcgct gcaaaaaatg gtagggaatc
     3481 tgagagatat tgtcggatat tctaaagaca tatcaagccg ggttctttct tcttcacagg
     3541 tgcttgcaac cgcaacgaat gaaacaagat ccggcagcaa acatattacc gagacgatga
     3601 acgaaatggc tgagggctct gaacagcagg cccaagacgc cgtgacgatt gccgaatcga
     3661 tgaatgagtt cactgaaagc attgataaag cctataatca cggcatcacc atcagcgata
     3721 cgtcgcaaaa cgttctcgaa ctcgcggtaa gcggaaacga aaatatggct acgtcattac
     3781 agcaaatgaa aaccatccat catattgttg aaaaagccgt gcataaagtg agatcacttg
     3841 aacagcattc tcaggatatc aacaagctcg ttcaggtcat caacgggatt gccgagcaga
     3901 cgaatttgct gtcccttaac gccgcgattg aagctgcccg cgcaggagaa agcggcaaag
     3961 gcttcgccgt tgtggcagag gaggtcagaa agctggctga cggcgtttct gattccgtgc
     4021 aggatattac ccggattgta ggcgggacac agcaggagat ccacactgtc attacgtact
     4081 tggaaagcag ctttacagaa gtcgaaaaag gaacggaaaa cctgacagac accggacagg
     4141 ctatgcggca tatcaagcaa tccgtcactc atgttgcaga cagcattaag gaagtaacgg
     4201 atggcctgaa gcagttaaca aaccaatcga ttactatcaa tcaatcgatt gaaaatatcg
     4261 cttctgtatc cgaagagtcg gccgccggca ttgaagaaac attttcaata accgagcaat
     4321 ccgcccattc gatggatcaa gtgcttcaaa atgctgaaga gcttgagcag ctggcgaagg
     4381 agcttaatga gaagatgggg cagtttacga tttaaaaata acccacgtcc agatagggcg
     4441 tgggtttaat gatttctata taagggtatt ttcactcgca cttctccgcc accctctata
     4501 gtgtttccaa gagtaagttc tccattatga agattcacag cattttttgc gaaggtcaac
     4561 cccattccat aatgaccttt agactgacgg gccttgtcat ccatgtaaaa aagttctgtt
     4621 gcttttttta gcccgatttc cgaaaatcca tttcctgtgt cttttacaaa aaaataaaaa
     4681 gtatcagaat cgcattcagc atgcaccgag acagtaccat cctccggtgt ataatcaact
     4741 gcatttgtta aaatattcaa taacgcccta tgtaacagtt gccagtctat ttccgcctct
     4801 ttcttgagat tttctttttt aaatgaaata tttatttttt tatttccttt ataggcggat
     4861 atatctttct gtagagtttc tgtcagctta tctacaaaag ctttctccaa atgaatagtt
     4921 aaggaatcct ccgttctcga gagatgaatc agctgagaaa tatattgttc aatttgattt
     4981 cctgctccaa gaatatattt tgtatattca gcttgttctt cgttttgaat agacaagctg
     5041 agtaattcag catttccctt aataatggta atcgggatct tgatatcatg tgctaaagca
     5101 ccaatttgct ctttcttatt tttttctaat cgccactgag cttcgagtga tgaccgaaga
     5161 gcatctctca tttcaattaa ggaatcaatt acatcatcaa attccttaat atgtgtaaat
     5221 tcgggagtaa actgcaaatt ttgctctttt atatatcgag taattacgtt cagtgtctca
     5281 aaatgttttc ttaatctatt agcaaagtaa gttgttataa tagaaatgac tacaatgagt
     5341 aagactatca aaatacaaat actcgttaat tcataattag gaaggtattt tcttaataaa
     5401 ggtgagctaa aatctgcacg taatgaatat tgcaaaatac aatactcttc atttctatct
     5461 ataaccaaat atcctttctg tttataattg acatacggtt ttttttcaat cttcttttta
     5521 accagttgca gatctttttc tttaatggtt ccagctgttt tttgttttgt ttctttatca
     5581 aggatggcat atgacattgt atctggaatc atatcagcag tgactttatc tgtattttcc
     5641 agctttggcg caagtttttc tgcttctcgt tcattataat tcgcgggatg tgagaaaccc
     5701 gtattcattg cgattgtatt tataaataaa tatagcagag ccagtacaac taaacttata
     5761 cataacgtga ccatatactt tatcagttct ctaagaagtg ttttctggcc cttaaaacct
     5821 attcccattt gtacccaaca ccccataccg ttttgatagg gtctgtatta tgctctttac
     5881 atttttttcg aatcgttctg ataaattcag taattgttga atacaaagca ttcccctcta
     5941 atccatatat ctcctcgtaa atttgttctc ttgaaaaagt tctcccttta tgttgagcta
     6001 aaaattcaca gattttatat tcattttttg ttaggttaag tttgtggtta ttgataaata
     6061 cttctttact atcaaaatga aataaaaaac cggagatgac tcttttcgat tgatgtttat
     6121 ctctccgttc ccttcttaag tgagcattaa ctctagcact aagctctcta acaccaaatg
     6181 gctttgtaat ataatcatct ccgccggtaa taagaccttt tactatcgct tcctcttctg
     6241 ttttagccgt gaggaataaa attggacaat caaccaaagg acgtatctgt ttacatagct
     6301 caaaaccatc aatatctggc atcataacat ccagcaaaat taaatcatat ccttgaaata
     6361 cgtcaggcgg ctgtccttta acacgatcta aaatgtcaac ttgatgctgg tcacggcgca
     6421 aaatattttg tatcagtaca agaatatctt tttcatcatc gacagcaagg attttggcca
     6481 tttcctgtcc ccctcatact attcaaacgt ttttctgcct tcccatttac taaaccatat
     6541 tagactggca acgattatac atattatacc aaaaatcata accaataccc ctgaatttat
     6601 ttcatgcatt aataaaggat tatccccttt ttctttaaag tggagtaccc catttaaacc
     6661 tgacaatcta ataccccaag cccaagggtt atatttccat atagcatctc ctaatccagt
     6721 attcattaga gcggtcataa gcaggccagc tccgcctatc aggacagaag cacccattcc
     6781 aaacatacag ctgataaaaa agtaaataca atatagggct acactacccg caactagcca
     6841 ggcaccacct gttataaaaa tatcgtaaga caaatccggc acatgtaaaa taaattttaa
     6901 tcctattata taaatgaaaa gcgctatacc aatagagcaa agttccatga aaagcagcat
     6961 taacattttg ctggcataag caatgacttt tggagacgta ctccctagta acacttgaaa
     7021 tttccctgcc tgttcttcta aggatgcagt cattccgcat aacaccccta taagcagcgg
     7081 caatgcaact gcaatagctt ccataaaaga cttatacaag tgaaattgac tctgatctct
     7141 ctcataaaaa tacagaatca atacagttga aaaagctata ggaataatta aatggagcca
     7201 cataaaggag gtgtgtttgc ttttctggaa atcagctttt aaacacctca aaagtaatct
     7261 caccttatat cgccccctgc ttttttgttc tgtaatcgat tgaaggggca aacgaacggc
     7321 tagtcaaaaa cgctattatt aaaaataata gaatagaaat caatatagca ggagggacga
     7381 ccatccaact caacaaagga tcattttttt caagcaacag accgttagga tgaataccta
     7441 ttgtgggaca catcattcga attggccagc tccaaggaat aaaccaccaa aaggaacgag
     7501 atgccggcat tatacctaga acaagggttc ctataagatt taacattacc gctattgtaa
     7561 gcccccactt ttttgccaca aataaacaaa gtggaatttg ccaaaggctt gttacccaaa
     7621 gcaataaact tgcggcaatt gcagaaagcg taacaatagc aaaatcagct ataacaaacc
     7681 ccattagtaa cataaacact aaaaatacaa tttgagataa tagcgaataa atcataataa
     7741 ttacaatctt agagtaccat aatcttccta aatcaatagg caatgaatac gtaccattat
     7801 aattagaggc ctttttttct ttttgatgag ataaagaaca aaataaagct atcatcaccg
     7861 gcataaatat aatagaccac cagttaaaag taccgggaac aaaaaattga atgttcatca
     7921 aaaaagaaaa acctatatta agcagcggca ctaagataat catttttcta gaaaaggtcc
     7981 ttttaaactt caggttttcg gccttcatat aattcatcat ctttttacac cctctttttc
     8041 acggcttgcc tttacaactt ccataaacaa atgctctaaa tcatcagtct tgtttatttc
     8101 cccctggtac ccaagatgac cgccgatgat aatcccaata tgatctgcta tttgctcgac
     8161 ttctgaaagt atatgactag ataaaatcac ggttattcct tcctgaggaa aagagcgaat
     8221 aagatctctg agctcctgaa tgccgattgg atctagccca ttcgtaggct catcaagaat
     8281 taataattta gggtgattta ataaagcaat agcaattccc agccgctgcc tcatccccat
     8341 tgaaaactgc cctgctcttt tctttccagc atgctgcata tctactgtct ttagcacgct
     8401 gtttatgcga tcctcagata ggcccagcaa cgttgcatgt acttttacat tttcaaatgc
     8461 tgttaaatta tcgtaaaggg gtggtgcttc tattaaagat ccgatatttt gcaaatcaga
     8521 acgtttccat ttatgtccgt cgaagaaaac ctcaccagaa gttttccgta aaattcctgt
     8581 taaaatttta agtgtcgtcg attttccagc tccatttggt ccaagcagac cgtaaatgct
     8641 gtttttttga acagttaatg aaacatctga aacagctgtt tctttgccaa acttttttgt
     8701 aagacttttg gtttctaata ggactgtact catgtcacac tctcccttat cccttttcat
     8761 tcttaatcaa aaccgctcga taatactcgc gattaaactc cacaatgatt tcatctttgg
     8821 catcagtatc ctcgttcgca ctgtaaacct tcccatagcg tagaggtttt ttctctctgg
     8881 tttcatccgg atcattagag atatacggtt ctttcagttc ttcttcagac catctctttc
     8941 cctcactatc tacaaagaag gtttgaccta ttgcccctat tacttttcct tttttgtctt
     9001 catcaacttt atctttcatc tgataaaggt tttcgttata gaccacttga tcgagctttc
     9061 ccttatcaat caagctctcc attgtttcag atgtttcgtt gttatcctca gtaaaatgca
     9121 ctgttttttt tgtttcttca acagttttat ctttaaactt cgttaatgct tgacaagcag
     9181 ataacataaa taaaacaata aaacagcctg aaatgtttac acatcttttc aaaaacacgt
     9241 acatcacctc aatcttatga attttcccca atagatgtta aagataaaat gaattcttcc
     9301 tctgcgcggt atctatgtgg gatgttgatc attctagaat acttttatca aaatttaatc
     9361 aaaatacttt ttctaactgg aaacttaaag catttgggct tctggcaaca cgatcaactt
     9421 gtctaaataa aaaagcgtga tcaggtcaca ctgtttactc cagatagatc tatctcatat
     9481 tgatctatcc attaaaatat gaatttctga ggaatttcct taaattgtct gtacatgata
     9541 aaaagactga cttgggtatg tattagagtg ttgtttaaat cgacttatcc atcatccccc
     9601 ttgttacttt tttccacatg aaaaacgggt gtgaaattta aactcattca cacccgttac
     9661 tttttacatc atttttaggc cctaactcta tgaaaaatag tatgtataac gctcaggaat
     9721 gcaaggagtc agagcaaagt gattcaatgg ttttacttat ttagagattt tgcagttaca
     9781 agttattgtt tgaaggaagc aagtttgcaa tacaccagtt acacacccag gtgtacaaag
     9841 tgattcactt ttccattgag gagtgatttt agagtcttgt ttagagactt ttactacatc
     9901 caaatcgaaa tcatcgaact ttgacatatt ggtcacctcc tttcaatacc tatatagtaa
     9961 cagacaaata tcaagatttt atcatttttt ccttttttta ttaaataagt aatgcttttg
    10021 tccaatctgt ttttgagcct aattccatgt ttaatagccc taatcctaca cctacagctc
    10081 catccaatag accgacgtac tgcaaaggta ctgcttcatt cccttcaatt gattcataat
    10141 tgtggaatcc aaagatataa tccttgtcat agtagctcat aattttttgt ttgatctttt
    10201 gaagctcttc gttaaaaaat tcttgtccag tgagttgatt tactgcaagc aaaatctgac
    10261 ttattccaca atagccatgg catatcgtag gcgaaaaaat cccctgtata tcagatgctg
    10321 tgcaccttaa attctgtaca cctatattca aaaatctagt attttgaagt gcttttcccg
    10381 ctttaacaat cgcaagacat actccaggtc tcccatagca ccaagcatct ctactaaaat
    10441 ttagagcctt aggtggagat ccgtattgat actcctcaaa gcttatattt cctttccaaa
    10501 acaagttgcc ttgatctttt tcagaaaatt ccagtaagaa atctaccatt ttttcaattg
    10561 cactttcttg cccctttact ttaattccct gcatgagtgc tgaagataga atgcaaatag
    10621 gaccaggtat cccatgtgct aatcccatat taaagtttcc gtttggataa gctttttttt
    10681 cgatatctgt aaactgattt tcagatggaa tatgccatcc aggaactttt tctccattca
    10741 tggtaatgtc ttcagttaat ctaaccagat accttaaaat atcaattaac aaatccttca
    10801 ttgccttatc ttcttgaaat agaaggaggt aacttgctat tccactgaca ccttctatta
    10861 catcgtagtc actcatatac acttcccgct gagaaaattc agttaacaat tgaggtacta
    10921 cttcagctaa atattcgtta atacgggaaa tgaaaccttt gtaataggtg aaatgttgcg
    10981 ataaacagac agctgccagt ccaatgccag ctgctccgga aaacattgat ggagtatgca
    11041 gccctttttc ttttatttca tttactaaaa tcgataaata tttgtgtcct aaatcgtccc
    11101 atccttcctc aggaaaatga gcgtgcaatt cgccatacag catacatatg cctggtatac
    11161 catgactcaa tgcggtcggc ttccaaggta taagaggaac ttccccaata ctgaggaagt
    11221 tatctttttt attcactatt tcaagtactt tatcgtaatt agaaacttgt cgagcgattt
    11281 ccttcaccag ttcaacttct atccctgata cagcgcctct tcccatttag taccgtcctc
    11341 ctctagcgga ttcatatagt tctcggattc atccatcttt ttatacagtg gacatgtttt
    11401 taataactct tcatgtgttc ctattcctac tatttcccct ttatccataa caatgatccg
    11461 atctgcaagt ttagcagcaa ccaatcgatg ggaaataaat attcctattt tatcttttga
    11521 caaactgaaa aaagtatcga aggtttcttt ttctgcaatt ggatctagcg cagaacttgg
    11581 ctcatccaaa atatacaaag aagcttccct aaaataagcc ctagccaaag caatcttttg
    11641 ccattgtccg ccggataatt gccttccttc atcaaaccat aatccaagct gtgtatcgaa
    11701 ttgataggat gaatgacctt ttaaaaaatc agcttttaca atatcgagga cctcatgcat
    11761 tttatttgtc tgatgtagtt tatcaatttg tccaaatcct atattttcct ttaaggtcat
    11821 ttcatatttc atgaagtctt gaaagagtgc cgcaatttgt tccatataac tgtccatatc
    11881 caattcttta atatttactc cattaaccaa aatgtcacct tgctgaactt catataatcc
    11941 ggtaaggagc ttaatgaatg tacttttccc tgacccgttt ggcccaacaa tggctattcg
    12001 ttctccttta ttcaatgaaa cattaatatg attcagtgtc tgttctcctt gattaggata
    12061 gataaagctg acattctgaa agataacaga atgaataggc tcaacaattt gcttcttgtg
    12121 accttgattt ttctcttctt ttaattccag aaattcatac aattgattca tatagagatt
    12181 gctgttatag atggaataaa tgctagtcat gatagactgt gagtgacttt gcaccagcga
    12241 aacagatctg atataactca tcacattacc gaccattatt tttcccgcaa aagcagacat
    12301 aatagcaata aatataatga cagctccaac taattgcact gcaatctcat atattaggtt
    12361 caaataagtt ttctttctca atatttttgt atcttgatca ataaaggatt ttttaatatc
    12421 ccagtatttg tttaataaat aatctttaag gttatacaat tttaattctt taaaagaaaa
    12481 atcgtgtgta agtatataac tgatatacca cgatttcctt tcctgtcctg ctcgtttcca
    12541 atgtataaaa aattcttgct gtccaatctt caaaaaatag aatagagaaa tcactggaat
    12601 aaccaacaag agcagcgaaa ctttagggtt ccatgacatc aaaaatgcaa ttgatgagag
    12661 cagagtcaca aatgaagtgg tcattgtaat gatggcttga atgatttggt aaggtttata
    12721 gctgatttcc ttagttaccc tttctaattt gtcgtatatt tcaggatttt cgaaatcctt
    12781 caatgctaga ttactgctct ttttcatgac tttatagttc agtttataac caatatttaa
    12841 ttggaattta ccattataat attcagaaac ctgagagatc agctccgaac aaaatgatac
    12901 gccaagatat gttaagaaaa tggagataac aactgaaaca tctttgcgta tagtcacaag
    12961 ggaattaatc aattcttggg aaatatagag tgaaacaatt ggcagaatac cggtaataat
    13021 actgaataaa attaacttta aaaacagtga tctttctaag gtgaaaatta atttgatagt
    13081 cttaggcatt tgtttcatga taaacagcag ctcttttagc tttagttgtt cctttacttc
    13141 catgctaaac taccattctt cttttgatat ctctgggcat ataaagagtg tctgcaaagt
    13201 gtaagtattt tagtttccat ttctctatca gtgccgaata aacgattgca atgtaggtga
    13261 attacactac ctatgcgtga atatactgct tctttgttat caaatgcctt gtttattaag
    13321 catgcataat tagctgcagc tatttttcta gttttcaata tttcatataa tattctgcca
    13381 tcacttgttt ttctgagatt atcccattct ctatcagagt tgcatatttc aatatacatt
    13441 tctctatcct tcttaaattc agtacgatac tcattctgca ggcaattttt ttataaaaac
    13501 gttaactgct cttcgaacgt aagctcgaac tgttctaaaa actgtatgac agaaaccata
    13561 cctgcgattt ccttgcttat cgcaatatcc ttcatgcgat gcattctgat catcgtttca
    13621 acaactttgc tatcttcaca gaaaacctgt tctgcagcat ccattaggtc tagcccgcca
    13681 tatcgttcta tttccctctc atattgggtg ataacaaact cagtaaccag tcctttttct
    13741 cttaagcttt tcagccaatt caataattgt ggaaataaac tgtacagcac ctctgctttt
    13801 ccattcaatc taagtcttat atgaggcttc ggatctcgat acctcataaa gaaatgtcta
    13861 actggatatt gatcagaaat ctggttataa aaatccgcta tttcaaaagc aattagctct
    13921 tcttctctag tttgtttaca ataaagttta ataaacagcc aatcttcaaa tggcatttta
    13981 attctttcgg atctattttc ctctactgag ttaaggaccg gtaatttcaa tggtttttct
    14041 ggttttttcc tgatcagcgg aacaacgatt tcccccgaat agacattttg gtttttatcc
    14101 tttaaagcat ttgcatcaag ctcagcagcc acaagttgta acggatggtt atgattcgtt
    14161 tttttaagtt cccagaaaaa aacatctaaa gtacgatcat cttctatatc aattaataat
    14221 cgattgtctg cgttaacgat ataaaatctt tgcggaagat cataagtacg atgaaattca
    14281 aaaaatgcag atttcacctc gtctatcgat gaattcgaat gaatgcttaa atcacttttg
    14341 tgtatcagcc attgttcaca tgataagatt atttctttat atttgatttc aggaatatac
    14401 ttaaaatcac tatagatgcc catccacggg aaatcattcc acttcctttt gccatctctt
    14461 gaaatttcca ataaaaatcg taagacattt ggcattaata aaggattaaa catatgattt
    14521 gattcaaaag acagaatttc gccagtacat ttatgtttgg cataaaagat atgtttttta
    14581 tcgattccaa ttagaacatc ttcagcttta acagaatcat tgtgatgcaa gacactgttt
    14641 gtaaaaaggt tcatttcttt ttcccgataa cttacatttc ttgttacatt tccagacctg
    14701 acctgattag gcacaatact cagctcacaa attttcttat ttttgctcgt taactctttt
    14761 tccttattat gtattttttt tacaacggca ttgattgaat cagataagtg agtaaacctt
    14821 ccaaatgttt tccctgcgcg tgtagatccg acatttggcc ctaaataaag catgactctg
    14881 ccattgcgca atttaacaaa gaaattgagt tcaaatgata ctggaatttc ttcatctgca
    14941 atttcataat tgcagattct atggaatgtt tcgtcatgta attgaatggg agctttcttt
    15001 ctaactgatt caaagtattt tttcataaaa aattgtttca tttcaggtga aaattgatcc
    15061 tcaaatgata tttcttcgaa gaattcatta acaggattcg tgtaagtagc aggggcacca
    15121 atgccagcgt tggaacaaag catttctaaa agaggaactt ctctttcata cccataacgc
    15181 tccaaaaaca catttttgta cttttctaag tggtctagtc tttctgcgga gggagcagcc
    15241 atataagtaa acatactagc caattcactt atcgcaagag atgtttcatt atctagttga
    15301 atggaggagt cacctaaacc cgtatccacc tgcagaggag atgaagtctt tatgagttcg
    15361 ttcattgttt caatcagatt taaatactgg tcctctccct ctccgatagt gatccggtta
    15421 tattcatcta tttgatattg tattttcctg caagcctgaa gaagctcatt tggaattcgg
    15481 ctgctttccg cttgagcaat taaatactga aattgatctg aaacagtcat tggcggccgt
    15541 aaatttgata tcaggaactc tttgtcaata agatctgcta cgtactgatt aattttgctt
    15601 attggagtat tttcatagtt ctctgtcaaa ctacgaataa tatcatgata agcaacacat
    15661 tcaccacaaa gttcattgat tagatggaaa accgatgttg cacgaacact aacctcttca
    15721 gattttccat ctgtgctata caacaagtaa gcacgatcac ctttgatgta acaagcggga
    15781 tttaatgtaa aagaaagccg gtcgatgtat tcgttttcta gttttctcgt caattgatag
    15841 agccactcaa aatcaacacg tgcttttttg taaaatgaat gctgattaaa agataattga
    15901 tttttatcgg agaatgcccc tatacccact gaagaaaaaa ggccaaaagg cgttgttcta
    15961 gttgctcttc ttgttgcata cttcaaaata gcttgctgga agttccgctt tttttttcct
    16021 tttaatttat caggcgtttg aaggaaaata ttcattgtgt catatagtgt cctgctagat
    16081 accagtattt gttcacgaaa taatgaatca ttacaaaggt catgcaataa ctgatctgta
    16141 tcctgagagt tctcattttt caaggcctga tgtaccaaag gaacccgaat catataataa
    16201 tctgtaggtg tatataagga tttcatctta gtctttaacc tcccatattt atccacttca
    16261 ataacaacaa gaattcaaca tcccttcgta aagtcctcca ttttattcat tccattctaa
    16321 aattttcata atattctatt taaactatac atttgaaaaa tcaaaaaaaa atcaagattc
    16381 acccaataaa tcccataaaa aaaggactct tttccctttt agaaaagaat cctttttgct
    16441 taactcgata cacgaattaa ctttcttcta tttttttgtt taactgggtt caacaatctt
    16501 tcaatccagg ccatgagcaa atccgcccct accgccatca ccgcagttgg tatcgctccg
    16561 gctagaataa tcgcagttcc gtttgtcgcg tttgagccgc ggacgatcat gtccccaagg
    16621 cctccggcac cgacaaatgt gccgatcgca gtaattccaa tggcaatgac gagagctgtg
    16681 cgaaggcccg ccataatgac agaaagtgcg agcgggagct caaccattct gagcacttgg
    16741 aatttcgtca tgcccattgc ttttcccgat tctaagtagg catgctcaat actgataatg
    16801 cctgtgtacg tgtttcgaat aatcggcagc agggaataca gaaataatga tagaatcacg
    16861 gtatttgcgc cgagccccat aacaagcatt aagacggcca gcatagcgag cgccgggatt
    16921 gtttgaataa cgtttgttac tgcaaacacc caggctgaca aacggcgaaa atgcgcgatg
    16981 aggattccgg ccggaacccc gacgacagcg gcaaataaaa cgccgtaagc cgacatgaga
    17041 aagtggcggc cgaattcatc catgacgtaa ctgccattct gcgcgtaata cgtcattaac
    17101 tgttcaagca cgttcattga cctcttcccc ctttcacgat tcgaagtagt gatgtttttc
    17161 taaatattcc ttggcaacga cagacggttc tttgagattg ccgtcgactt catagttaag
    17221 ctcctgcatc gtggctgtgt cgatttttcc gagcattttc ttgatgatgc cttcaagctc
    17281 aggatgttct ttgagcacct tttccggaac aaccggagaa cagtcgtacg gcgggaaaaa
    17341 ttgtttgtca tcctttagca ttttgagacc ataggacttg attcttccat cggttgaata
    17401 cgcaagcaca atgtccattt ttccgttttt caccgcgtcg tacacaaggc cgatctgcat
    17461 cggatacgtg ccgccgaatg tcatgccgta ggttttcgta aaatcctgat agccgtttcc
    17521 tttgagcttc atccaatagt tgtcaacgcc cagctttaat tgcggcgccc attttttaac
    17581 gtctgatacg gtctctaaat ggtattggtc ggccagctcc ttgctgactg taaaggcata
    17641 tgtattatca aacccgtagg agtcatacca ctttaaatca tatctttttt taaactcccg
    17701 ctgagtaagc gccagcgctt tgtccggatc tttttcaggt tccattctca gcgtgcctgt
    17761 cagcgcgtct cccgtatatc ttgtggccgc aatgtcgatt tcatcattca ttaaagcctg
    17821 ctgctgcacc gcgttggagc caagattttt aatcgttgtt gttttgagat ctgtatggtg
    17881 ttcgatcaac tgaccaagca tgctggcgat gatttctgat tcgctcatgc tttgcgcgcc
    17941 gattttaatg gtctggtctg cagcagcgct gagaccagga agcgaacatc cgctcagcgt
    18001 cagcgttgcc gcaagtgcta aacctatcat taatttgaga tattttcttt tcatgagccg
    18061 cctccttatg acaattcctt caatctctgc atgccggcag gtgtcagttt tcgttcagca
    18121 actgccagca cataatcaat cacaattgcc aatatcgtga caggtaccgc gcccccgatg
    18181 atatattccg gctgatataa attcagtccg ataaaaatgt aatcacccaa tccgccgcct
    18241 ccgataaagg aagcaagcgt ggcccagccg attaagtaaa tcgtcgatgt tctgattccc
    18301 gccatgatca ctggcgcggc aagcggcagc tccaccaagc ggacttgttc agccggcgtc
    18361 attccgatgc ctttgccaga ctcgagcaga tttttgttga cgccgcgaat gccggtatac
    18421 gtgttgcgaa gaatcggcaa tacggaatag aaaaacaaag ccacaatggc cggaaccttt
    18481 cctacaccaa ggagcgggat aaaaaaagcg aggatggcca gactcggcag cgtctgaatg
    18541 atattgacaa tgccgataat ggtgccggct ccttttttca ttctggtaag cacaactccg
    18601 agggggacgg caaccagcac acctaagatc acagcaatga gcgatatcgt aatatgctcg
    18661 tatgttttat aaagaagctc gcccccattg gtttgcaaaa attgaacaat atgatgcatg
    18721 acttatcgcc cctccctatg acaatgctgc gagctgcttt tcttctcccc agagggagtc
    18781 atacacgatg tcgaccagac ttgccctcgt cacaattccg atcaggcgtc gatcttcatc
    18841 cacaacggga acatatttga caccccgttt taaaattttg cggaccgtgt cgcgcagcag
    18901 tgtgccgccc agtactgtgt atatatcttc atgtaaaacc tcacctatga gattggcctt
    18961 tttccggcat tgatcaatga tttcaacatc gacatagcct tgcagaacgt gctcgtcatc
    19021 gacgaccagc aatgaatcga cccgttcctg cctcatcagc tgaatggcct cagaaagcgt
    19081 tttatccgcg gtgatcgtta caggctgtgt gttcataatc tggtcaaccc gttcaacatc
    19141 cgggctggat gactgaatca gccgctcctt gccgataaat tcctcaacaa attcgtctgc
    19201 cggatttctt aaaatgtcat cgggcgttcc tacttgaacg atttctcccg cttttaaaat
    19261 cacaatccgg tctgccagct taatcgcttc atccatatcg tgggtaacaa atacgatggt
    19321 tttatgtaag gttttttgca gttttttaaa ttcttcctgg agggaatccc tcgtaatcgg
    19381 gtcgagtgcc ccaaacggtt catccattaa gataagcggc ggctccgcgg caagtgcccg
    19441 taatacacca attcgctgct gctgcccccc gcttaattca tgagggtaac ggtctaaata
    19501 ttctggcccc atatcgacca attttaaaag ctcacgcgcc cgctctttcc gctgctgctc
    19561 cggccatttc agcagttttg ggacgagtga gatattctgc tgaatggtca tatggggaaa
    19621 caggccgatc tgctgaatca catagccaat tttgcgcctg agctctacag gatcctggtc
    19681 catgatgttt tcgccgtcaa tgaaaatctt tccggcggaa ggctcaatta atcggttaat
    19741 cattttcatt gttgtcgttt ttccgcagcc gctcggccca ataaagcaga taaattcgcc
    19801 ttttgcaatc ttaagattta cgttgttcac agcttttttg ccgcccttgt atgttttcga
    19861 gacattttct aatgtcagca aacatcgcac ctccaaaatt aagtttattc aatttgttca
    19921 gtttaaattt aatttttcag acaattgaat gcttcccatt atagaataaa gtttataaaa
    19981 taaaaagttt acaatttgtt catattattt ataaagtatg tgtaaacgct gatttacccg
    20041 cattgacgtg tgttgatctc cttattgctc caatttcctg ccaaattctc ttttgacagc
    20101 attttcgccg tatcaaaaat gtggtatatt gacatcggaa ttgttagctg aaaggatgaa
    20161 accgttggag aaagatccgt taacgatcat tgaacaagcc gaggaccatt ttatagaaag
    20221 aatcgcggaa aacatgcatg catttggaat gccctctacc gtcggacgag tgctgggcat
    20281 tatttatatg aatcgaaaac cgatgacgct tacggaatta tctgaggcta ccggcatgag
    20341 caaaacacgc atgagccagg tagtgcggga aatgcttgat gccaacattg ccgagaaggt
    20401 gttcgaaaaa ggcgtgcgaa aagatttata tgaggttgag caggactact atcaaacatt
    20461 tatcacgctg ttttcagcca cctggagcaa agtcgtcagc aaaaacaaaa tgatgcataa
    20521 aaaactcaat cgggaactgc ttagcgtgtt ggatgaagag cttactcctg aagcggaaga
    20581 aaaagtgaat gaactgctga aagaattaaa ggaatggctt gattattata attggctcag
    20641 ccgtttgatt gagttttttg agagcgaaga aatttttaaa tatgtgccga agccgtaaaa
    20701 aacgccctgt cattacaagg cgttttttct tatgcggcac ctgccagatt tttcttcttt
    20761 ctctttttaa tcgggcttaa tgctcgttca agccagccca tgaccaaatc ggcaatcacc
    20821 gccatcagag ctgtggggat cgctcccgct aatataatcg cggttccgtt tgtggcgttt
    20881 gatcctctga cgatgatgtc cccgagaccg ccagcaccga caaatgtccc gatggccgta
    20941 atgccgatgg caatgacaag cgcggtgcgc aggccggcca ttatgacaga aagcgcaagc
    21001 ggaagctcga ccatccgcag cacttgaaat tttgtcatcc ccattgcttt tccggattca
    21061 agataggcgt gctcaatact gataatccca gtatacgtat ttctgataat cggcagaaga
    21121 gaatacagaa ataatgacaa tatcaccgta ttagcgccca gccccatgac aagcatcagc
    21181 acggcgagca tggcgagagc cgggatggtc tgaatgacat tcgtgaccgc aaaaacccat
    21241 ccgcttaatc ttctgtatct ggctatcagg atgccgagcg gaattccaac aatggcggca
    21301 aataaaacgc catacaccga catcagaaaa tggcggtaaa actcctgcag cacgtaaccg
    21361 ccgttttgcg aatagtatgt gccaagctgc tgtagtactt ccatatgatc cacctctttt
    21421 cttagtcaaa ataatgatgt ttctctaaaa attcctttgc tacgacagac ggctccttca
    21481 gcttgccatc cacctcataa ttaagttcct gcatcgtttc cgtgtcgatt tgcccaatca
    21541 gcttattgat cacaccttca agttccggat gctccttaag caccttttcc ggaatcaccg
    21601 gtgaacagtc atacggcgga aagaaacgct tatcgtcttt taagattttc agatcatatg
    21661 ctttaatccg tccatccgtt gaataagcca aaaccgcatc cattttcccg tttttgactg
    21721 cgtcatagac tagcccgatc tgcattggat aagttgtgcc gaactcaaag ccatatgtgc
    21781 tgacaaagcc tttatacccg tcgccttttc gtttcagcca agcattgtcg acgcctaatt
    21841 tatattggga agcatttttc ttcaggtcag acacggtgtt aatatgctcc ttttccgcaa
    21901 acttttttgt tacggtgaag gcatatgtgt tatcaaagcc gtaggaatca aaccatttat
    21961 aagaaaagcg cttttgaaac tcgttctgca caatgttcag cgcttttttc ggatctttct
    22021 ccgcttcctt gccgagggtg cttgttaaat ctgttccgga atagcgcgtg gctgaaatat
    22081 caatgtcacc gcccagcatc gcttggtgct gaacatagtt tgagccgagg tttttcacta
    22141 aagcagtatt caaatctgta tcatgttcaa taagctgcgc gatcatattc gctaaaattt
    22201 ctgattctgt catgctctgc gccccgattt tgatcgtatc gtcagaagcg ccgcctagac
    22261 ccggcagaga gcagccgcct agcagcatga caaagacgag agcaaacgcg ccaagccatt
    22321 tgatttttgt cattttcaac agtgccaact ccttacgaaa cttccttcat cccttgcaag
    22381 cctttcggcg tcacctttcg ttctgtcaca gccagcacat aatcaataat aattgccaga
    22441 attgtgacag gcacggcacc gccaatgata tattcaggct ggtataggtt cagtccgata
    22501 aaaatatagt ccccgaggcc gcctcccccg ataaacgacg caagtgtcgc ccagccaatt
    22561 agatagatcg ttgatgtgcg gatccccgcc atgatgatgg gaatcgccag cgggatttca
    22621 acgagccgaa tctgctccca gccggtcatg ccaatccctt tccccgattc caggaggttt
    22681 ttatttacac ctttaatgcc ggtatacgta ttgcgcagga tcggcagcac cgaatagaaa
    22741 aataaagcga caatcgcagg cacttttcct acgccgagaa gcggaataaa aaaggctaaa
    22801 atcgccagac tcggcagggt ttgcacaatg tttacgaaac cgattaccgc acctgcgcct
    22861 tttttcattc tggtaagagc aacgccgagc ggcactgcaa cgataatgcc caatacaacg
    22921 gctatgagtg aaatatataa atgctctcct gttttataca acagctctcc gccgttcgtt
    22981 tgcaaaaaag tcatcatttg attcatctta aaagagctcc tcccctggtc agatcgtcat
    23041 gagctggttt tcctcgtcgc cccaaatgga atcgtatacg atatcaacga ggctcgctct
    23101 tgtcacaatc cctgctaaat ggttctgttc atcgaccacc ggaacatact tgatcccctg
    23161 cttcaaaatt tttcggactg tatcgcgaag aagcgcccct ttttgaacgg tatatatatc
    23221 tgaacggtat acatcgccaa cgatgctcgc ttttttgcgg ttttgatcaa tcatttccac
    23281 atcaacatag cccttcagca cgttttgccg gtccacaacg agcagcgagt caacacgttt
    23341 ttctctcatc agctgaatcg cctgagaaag cgttttgtcc gcagataccg tcaccggcgt
    23401 tctgttcatc atttgctcta cccgctcgat atccggtctt gactgaatca ggcgctcttt
    23461 cccgataaat tcttcaacaa actcatttgc cgggtttcga agaatctcat caggtgtgcc
    23521 gacttgaacg atttctcccg cttttaatat cacaatcctg tcagcaagct taatcgcttc
    23581 atccatatcg tgggttacaa acacaatcgt tttgtttaag gttctctgca gttttttgaa
    23641 ttcttcctga agggaatcac gcgtaatcgg atcaagcgct ccgaacggtt catccattaa
    23701 aatgagaggg ggttccgctg ccagggcgcg cagcacgccg attctctgct gctgtccgcc
    23761 gctgagctca tgcggataac ggtctaaata ctctgggccc atatccacaa gctttaacag
    23821 ctcgcgcgcc cgttctttcc gtttttcctc aggccatttc agcagctttg gtacgagtga
    23881 gatgttctgc tggatggtca tatgggggaa caaaccaatc tgctgtatca catagccgat
    23941 ttttctcctc agctcaaccg ggtcctgttc cataatattt tctccgtcga taaagatcct
    24001 tccagacgat ggttctatca gtctgttgat catcttcatc gttgtcgttt ttccgcagcc
    24061 gctcgggccg ataaaacaga taaattcacc tttggcaata tctaaatcaa tgctgttcac
    24121 agcttttttg ccgcctttat atacttttga cacttgttcc aatttcagca atccgtgcac
    24181 ctccgcaggt ttcctttaaa ttttctgaaa agtataatcc ttattatagt ttgaactttg
    24241 taaaataaaa agtttacaat gtgttgaaat tatatgttat ttatagatta tttattgtta
    24301 tgaccgagac ggaaagggtg ttcttacaat tacgccggat acctcccact tcctcagcat
    24361 tcagctattt tcaacaccag gaagaaatat gatatattga caccatcaat tgccatttga
    24421 agggatgatc agctgtgaaa aaaaccgctc tcgacatcat tgaacatgct gaagagcatc
    24481 tcattgagaa gattgccgaa aatatgcata cgtttggaat gccttcaact gtcggacgtg
    24541 tgctcggaat tatttatatg aatcgaaaac caatgacctt aagcgagctc tctgaggcaa
    24601 cgggcatgag caaaacacgg atgagccagg ttgtccggga aatgatcgat gccaatatcg
    24661 ccgaaaaggt gtttgaaaaa ggcgtacgaa aagaccttta tgacgtcgag caggattatt
    24721 atcaaacctt catttcttta ttcgcggcga attggacaaa ggtcgtgagc aaaaacaaag
    24781 tgctgtataa aaaattaaac cgggagctga gtgatctttt acaaagggac gggcttaccc
    24841 cggaagcgga agagaaagtc aatcagctgc tgaatgaatt aaaagaatgg cttcattact
    24901 atgattggct gagcaggttg attgaatttt ttgagagtga ggaagtcttt cggtatgtgc
    24961 cgaaaacaaa agaaagcagc tctctaaaat aagagagctg ctttttgcat catgaggtta
    25021 agaccggaaa catgcctttc agcccggcac caatcatccc gaccgcaacc acggctaaga
    25081 ttaatcccat gagtctggta atcacattca tctcggtttt tccgagtttg ctgctgataa
    25141 aagcagaata gtggaaaaag agaaaggtca gggcaataac ggcggctatg ccgatcatga
    25201 cagccgcata atgaccaatg ccgctatgtc cggcggaaag gctcatcact gttgcaatcg
    25261 ttccgggccc agcaatgatc ggaatggata aaggtgtgac tgatatatcc gctttttcct
    25321 tgctttcctt atgttcatca tggtgaagag attgcacgtg cgattctttc gcattcaata
    25381 gattataggc aatgccgaaa atgaatatgc cgcccgccac tcggagcgcg tgaatgttga
    25441 tatcaaacag tttaaagata agatggccga aaaccaaaaa agctgcgaga ataaaaaagg
    25501 ataaaatagc tgccttccgg gcaatcgctt ttctttccgc tgcagtatag ccttctgtca
    25561 gcgtcagaaa tatcggtacg tttccgatcg gattcgatac tgcgaataaa gaaatgaaga
    25621 cgtgaacgat aaatgagaac atcatatacc tccttgttga tagtctctgc acaggaaata
    25681 gaatgattct ccaccctttt acccggaggc gatttcccgg taaaccttta tagcctgtca
    25741 gaaacgcgcc atgctacaat gaagtgacaa attgaatagg aaggacgtat acagatgttc
    25801 aaaaaaattg cggcagatgc cttgggctta tctgatatcg gaaaaattat cgaacctcag
    25861 gactatgaca aaacagacgc agatgattat gtcatgcatg aagataatga gaaaatttat
    25921 ttcttgatta aaacaaaagc agacgagtat tgctttacga acctggccct gatccatgta
    25981 gacggcgaac gcgccacttc ctcgaaacga acgttgaaac gctatcctta ttcgcaatat
    26041 aaaatctctg acgtttttct tgaaactgcc ggaaaagtgg atttggatgt tgaaattaag
    26101 ttcaagctgg gcggagaaca attcgacatt gatgtccaca aagaccagat tgaaaaatta
    26161 aaagaccttt ataaagctct tctccgcatc gctgaaacaa cctatgaaaa tgacatttta
    26221 atcaat
//
