LOCUS       NZ_NJRD01000003        21612 bp    DNA     linear   CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain 20-3 20-3_R1_(paired)_contig_3, whole
            genome shotgun sequence.
ACCESSION   NZ_NJRD01000003
VERSION     NZ_NJRD01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 1055472)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1055472)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010578135.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:42:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,274
            CDSs (total)                      :: 4,198
            Genes (coding)                    :: 4,064
            CDSs (with protein)               :: 4,064
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1 (5S, 16S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 1 (5S, 16S)
            tRNAs                             :: 67
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 80 of 134
            Pseudo Genes (incomplete)         :: 67 of 134
            Pseudo Genes (internal stop)      :: 22 of 134
            Pseudo Genes (multiple problems)  :: 31 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 662442
            Orig. end                         :: 684054
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NJRD01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21612
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /region_number="4"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     cand_cluster    1..21612
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21612
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11612](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11612
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     misc_feature    complement(87..101)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.21"
                     /tool="antismash"
     gene            complement(179..3865)
                     /gene="narG"
                     /locus_tag="CE053_RS09080"
     CDS             complement(179..3865)
                     /GO_component="GO:0009325 - nitrate reductase complex
                     [Evidence IEA]"
                     /GO_function="GO:0008940 - nitrate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009061 - anaerobic respiration [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="narG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391609.2"
                     /locus_tag="CE053_RS09080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitrate reductase subunit alpha"
                     /protein_id="WP_085185526.1"
                     /transl_table=11
                     /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRWQ
                     YDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGASFS
                     WYIYSPLRVKYPYVRGVLINLWREALQAHQNPLDAWKSIVENPEKAKSYKQARGKGGFV
                     RAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPMLSFY
                     DWYADLPPASPQIWGDQTDVPESSDWYNSGYILTWGSNVPLTRTPDAHFLAEARYKGAK
                     VISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEYAKQYTD
                     FPFLVTLSKENGVYTAGRFLHAKDIGRQTKHDQWKPAVWDEQTSSFAIPQGTMGSRWDG
                     QQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLPIKKMNLNG
                     EETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKEAVVKIAREF
                     AQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGWAHYVGQEKLR
                     PAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPIAASSRYKHHAD
                     YNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQLQEKKLKFAIEDP
                     DNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDSIRPEEIKWREQAP
                     EGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFIHPFAPAISAPWESK
                     SDWDIFKALSKAVSDLAEEVGMEPVKEVVATPLLHDTMQELAQPFGKINDWSKGECEAI
                     PGKTMPNIQVVERDYKHIFHKMTAFGPNVALKPSGTKGMSWSIADEYESLKQRLGEITS
                     DSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENITNLKLKDLAEEREEECF
                     TFEQITAQPKTVITSPAFSGSEKGGRRYSPFTTNVEKLIPWRTLTGRQSYYVDHELMME
                     FGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKWSVHSMYFDSLPMLTLFRGG
                     PTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHRIPKGMAFMHHAQDRHINVPG
                     TKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYYGPTGNQRDLNVVIRKLKEVDW
                     LED"
     misc_feature    complement(3931..3946)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(3955..3968)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.07"
                     /tool="antismash"
     misc_feature    3955..3969
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.64"
                     /tool="antismash"
     gene            complement(4084..4560)
                     /gene="arfM"
                     /locus_tag="CE053_RS09085"
     CDS             complement(4084..4560)
                     /codon_start=1
                     /gene="arfM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391610.1"
                     /locus_tag="CE053_RS09085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Crp/Fnr family transcriptional regulator ArfM"
                     /protein_id="WP_003243032.1"
                     /transl_table=11
                     /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSFL
                     HSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSDIL
                     ILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS"
     misc_feature    complement(4618..4633)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            4704..5423
                     /gene="ywiC"
                     /locus_tag="CE053_RS09090"
     CDS             4704..5423
                     /codon_start=1
                     /gene="ywiC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391611.1"
                     /locus_tag="CE053_RS09090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YwiC-like family protein"
                     /protein_id="WP_029726074.1"
                     /transl_table=11
                     /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYLA
                     VYPVTLALKKKQSKPYQKWMCYYGFPACCFLMISVFHKPPLIWVGVSLLPLFLIHMYFA
                     RRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVKSVI
                     RERKNRTFAYWSWGYHLLLPFLSALFGAGWSFLAFIPSSLRAWFFHGRDWPVKTIGILE
                     IVNACFFLAVMCLFITR"
     gene            complement(5455..6171)
                     /gene="fnr"
                     /locus_tag="CE053_RS09095"
     CDS             complement(5455..6171)
                     /codon_start=1
                     /gene="fnr"
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391612.1"
                     /locus_tag="CE053_RS09095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fumarate/nitrate reduction transcriptional
                     regulator Fnr"
                     /protein_id="WP_003227573.1"
                     /transl_table=11
                     /translation="MNFLSVRPSDSDLISSDLHELLESISTKRKMEKHTYLFREGMDAE
                     ELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEVLV
                     INKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSNSYG
                     VERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKRDYLR
                     CEIECENCPLEICNID"
     gene            complement(6270..7457)
                     /gene="narK"
                     /locus_tag="CE053_RS09100"
     CDS             complement(6270..7457)
                     /codon_start=1
                     /gene="narK"
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391613.2"
                     /locus_tag="CE053_RS09100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitrate transporter NarK"
                     /protein_id="WP_014478287.1"
                     /transl_table=11
                     /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEIS
                     LVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGGFF
                     LGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKSTVQ
                     MYLVLLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAFVAFT
                     IYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFAGLTLS
                     GIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAMGGLGGF
                     FPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQSIN"
     misc_feature    complement(7522..7537)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            complement(7593..9263)
                     /gene="argS"
                     /locus_tag="CE053_RS09105"
     CDS             complement(7593..9263)
                     /EC_number="6.1.1.19"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004814 - arginine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006420 - arginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391614.1"
                     /locus_tag="CE053_RS09105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arginine--tRNA ligase"
                     /protein_id="WP_003227570.1"
                     /transl_table=11
                     /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHGD
                     YSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTKLI
                     PSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDV
                     SREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEYGDRF
                     VNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALEALRE
                     KGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDKLINVWG
                     ADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVTMRDLIEE
                     VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQGEEQGLKP
                     AADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALHSFYNAEK
                     VIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM"
     gene            complement(9260..9688)
                     /gene="ywiB"
                     /locus_tag="CE053_RS09110"
     CDS             complement(9260..9688)
                     /codon_start=1
                     /gene="ywiB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391615.1"
                     /locus_tag="CE053_RS09110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1934 domain-containing protein"
                     /protein_id="WP_003243604.1"
                     /transl_table=11
                     /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYYE
                     EHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKSIQ
                     SDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA"
     misc_feature    9895..9910
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.99"
                     /tool="antismash"
     gene            10001..10132
                     /gene="sboA"
                     /locus_tag="CE053_RS09115"
     CDS             10001..10132
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="sboA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391616.1"
                     /locus_tag="CE053_RS09115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="subtilosin A"
                     /protein_id="WP_003222002.1"
                     /sec_met_domain="Subtilosin_A (E-value: 2.3e-29, bitscore:
                     97.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
     CDS_motif       10001..10030
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MKKAVIVENK"
                     /locus_tag="CE053_RS09115_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       10031..10132
                     /prepeptide="core"
                     /locus_tag="CE053_RS09115_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="33.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAVIVENK"
                     /leader_location="[10000:10030](+)"
     gene            10089..10241
                     /gene="sboX"
                     /locus_tag="CE053_RS09120"
     CDS             10089..10241
                     /codon_start=1
                     /gene="sboX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_054594.1"
                     /locus_tag="CE053_RS09120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin-like protein SboX"
                     /protein_id="WP_010886632.1"
                     /transl_table=11
                     /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIHT
                     QPFFI"
     gene            10266..11612
                     /gene="albA"
                     /locus_tag="CE053_RS09125"
     CDS             10266..11612
                     /codon_start=1
                     /gene="albA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391617.1"
                     /locus_tag="CE053_RS09125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="subtilosin maturase AlbA"
                     /protein_id="WP_003242599.1"
                     /sec_met_domain="subtilosin (E-value: 0.0, bitscore:
                     1080.5, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 1.3e-29,
                     bitscore: 98.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 8.6e-08, bitscore: 28.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 3e-45, bitscore:
                     150.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 8.9e-07, bitscore: 24.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.8e-22, bitscore: 75.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-10, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4.2e-10, bitscore: 36.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLN
                     KTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRASR
                     HTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADMLFDN
                     GVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQKIIVG
                     ISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHDMAQKV
                     RDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPIIPYERKR
                     AANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLWQAQAPRF
                     SEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI"
     aSDomain        10281..10556
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CE053_RS09125_Subtilosin_rSAM_RRE.1"
                     /evalue="3.40E-31"
                     /identifier="RREFam018.1"
                     /label="CE053_RS09125"
                     /locus_tag="CE053_RS09125"
                     /protein_end="97"
                     /protein_start="5"
                     /score="98.4"
                     /tool="antismash"
                     /translation="MFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLNKTAYE
                     LCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQ"
     gene            11625..11786
                     /gene="albB"
                     /locus_tag="CE053_RS09130"
     CDS             11625..11786
                     /codon_start=1
                     /gene="albB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391618.1"
                     /locus_tag="CE053_RS09130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbB"
                     /protein_id="WP_003222006.1"
                     /transl_table=11
                     /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGM
                     RARKADSR"
     gene            11783..12502
                     /gene="albC"
                     /locus_tag="CE053_RS09135"
     CDS             11783..12502
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="albC"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391619.1"
                     /locus_tag="CE053_RS09135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_003227564.1"
                     /transl_table=11
                     /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTT
                     LINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVS
                     FVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILD
                     EPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQKVIPI
                     GEETDLRREFFEVIGHE"
     gene            12495..13805
                     /gene="albD"
                     /locus_tag="CE053_RS09140"
     CDS             12495..13805
                     /codon_start=1
                     /gene="albD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391620.1"
                     /locus_tag="CE053_RS09140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbD"
                     /protein_id="WP_003243158.1"
                     /transl_table=11
                     /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQA
                     GIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVVLF
                     VDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVKKKN
                     LMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHSFMRR
                     SEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISALLLIC
                     SPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFISGRSIS
                     VLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPLFLAILAG
                     TAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS"
     gene            13795..14955
                     /gene="albE"
                     /locus_tag="CE053_RS09145"
     CDS             13795..14955
                     /codon_start=1
                     /gene="albE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391621.1"
                     /locus_tag="CE053_RS09145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbE"
                     /protein_id="WP_072692833.1"
                     /sec_met_domain="Peptidase_M16_C (E-value: 1.2e-05,
                     bitscore: 21.4, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYLK
                     EQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSFPS
                     SLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRKDRIKAIHP
                     KRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFETETRS
                     AAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHVITRYD
                     VMNNLLLVSICTDQLHEIDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQFDSPEGL
                     LAYMGILRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG"
     gene            14960..16240
                     /gene="albF"
                     /locus_tag="CE053_RS09150"
     CDS             14960..16240
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="albF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391622.1"
                     /locus_tag="CE053_RS09150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pitrilysin family protein"
                     /protein_id="WP_003227558.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 6.5e-14, bitscore:
                     48.2, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDFG
                     SRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNFMF
                     TSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLISMLS
                     PSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPHLQLE
                     KRPDYHAERKIIPACPPALSQKMVLGDEERMEDTWTGLQIGALPGQNDLLSIKLYWDIA
                     ARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYIDVASYYV
                     TQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHIIQDMDAQ
                     VFLSLIDAMASSNKAIIHVSQKEAIRQ"
     gene            16237..16938
                     /gene="albG"
                     /locus_tag="CE053_RS09155"
     CDS             16237..16938
                     /codon_start=1
                     /gene="albG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391623.1"
                     /locus_tag="CE053_RS09155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbG"
                     /protein_id="WP_003227556.1"
                     /transl_table=11
                     /translation="MIKNTVFTLLLLLIGMAAYSFGWVQVVAEAAAQYVQMINNDAVRL
                     GLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVK
                     SLRDSYKNVRQTYVMAAVLCQVFIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILYLLF
                     CMRTYLRQLFRHGSLFRKVFAGVLAAAGIWWMLSFSISELLFLIILAAIQQIGSFIYKR
                     FSYRSTASLDL"
     gene            complement(16944..18320)
                     /gene="ywhL"
                     /locus_tag="CE053_RS09160"
     CDS             complement(16944..18320)
                     /codon_start=1
                     /gene="ywhL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391624.1"
                     /locus_tag="CE053_RS09160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YncE family protein"
                     /protein_id="WP_015714888.1"
                     /transl_table=11
                     /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDIPEGFKVDSAEAS
                     AAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGDGA
                     VSVIHTEEIDQVVYYAAQSDRCPDFSQMIVEDLLIVPPFYGSPLTVAGTLVLPPSPDPQ
                     SYVFTANTGDSTVSVIDADLNTVVKTIPFSAVPTNLGVTFDKAFTYILHGNTNLVSVID
                     NKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPGALDFA
                     LDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLIATPYAGNFAYVLNGELW
                     PKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNLYVVNTAR
                     QRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYCTSDYTAVTVIPVGAGPSAIAM
                     "
     misc_feature    18287..18304
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            complement(18359..19714)
                     /gene="ywhK"
                     /locus_tag="CE053_RS09165"
     CDS             complement(18359..19714)
                     /codon_start=1
                     /gene="ywhK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391625.1"
                     /locus_tag="CE053_RS09165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YncE family protein"
                     /protein_id="WP_015250986.1"
                     /transl_table=11
                     /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFVV
                     DPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRNQY
                     GQGDGAVSVIHNAEIDQVVYYSDEPDDCPDISDITIENLVVVPPFYGSPLSVTGTIVLV
                     PEPEPVYAFTANPNDQSVSVIDTNTHTVVTTIALPYNPAGIEITPDKSAVFVLHPNNNV
                     ISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAIYVIGIDTLTVERSIPVEG
                     FDIAIDPNGLFAYVLNFGLVQKVDLSTGEVLGTIERELIVSSIETDSTERYAYVLEQEF
                     LFNYLTVIDLNTFTIRDTQELEPDGLYVMFTSGSEVYLHDSFTGNLYSVSPNGAGVIGN
                     LPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAITI"
     gene            complement(19711..19941)
                     /locus_tag="CE053_RS21555"
                     /pseudo=""
     CDS             complement(19711..19941)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009968328.1"
                     /locus_tag="CE053_RS21555"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQIPPFIILYMSYFIINILVRSAKKPQFFLSLHRMFGDIFSKRSV
                     YPQ"
     misc_feature    19895..19911
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.81"
                     /tool="antismash"
     gene            19944..21089
                     /gene="rapF"
                     /locus_tag="CE053_RS09175"
     CDS             19944..21089
                     /codon_start=1
                     /gene="rapF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391626.1"
                     /locus_tag="CE053_RS09175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator aspartate phosphatase RapF"
                     /protein_id="WP_113712952.1"
                     /transl_table=11
                     /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQMEE
                     DQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYYFN
                     FFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFSMDY
                     ARQAYEIYKENEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQPQLMG
                     RTLYNIGLCKNSQSQYEDAITYFKRAIAVFEESNILPSLPQAYFLITQIHYKLGKMDKA
                     HEYHSKGMAYSQKAEDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYADLEDFA
                     IDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV"
     gene            21073..21192
                     /gene="phrF"
                     /locus_tag="CE053_RS09180"
     CDS             21073..21192
                     /codon_start=1
                     /gene="phrF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391627.1"
                     /locus_tag="CE053_RS09180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatase RapF inhibitor PhrF"
                     /protein_id="WP_009968329.1"
                     /transl_table=11
                     /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI"
ORIGIN
        1 tttatatttg tcctggtcct cccattgctt cgggtagccg atgcccggct ttgtttctac
       61 attattgaag tacatatatt ccgcaccgga acggtttgtc cacgtgtttt tgcaggtgac
      121 gctgcacgtg tggcagccga tgcatttatc caagttcatg accataccga tttgcgcttt
      181 aatcttcaag ccaatcgacc tccttcagct tgcggatgac gacgttcagg tcacgctgat
      241 tccccgttgg accgtaataa ttaaagccgt agctgagctg ggcgtagcca ccgatcatct
      301 gtgtcggctt gacgtgaatc cttgtcgggc tgttatgggt gcctccgcgg ttattcgtca
      361 gctttgtgcc gggcacgttg atgtggcggt cctgggcatg gtgcataaac gccattcctt
      421 taggaatccg atgagacaaa accgctctcg cgacgacaac accgtttcgg ttaaagcatt
      481 caatccaatc gttgtctttg atatccgtgt cctctgcatc atctttattc atccacacgg
      541 tcggcccgcc gcggaacagc gtcagcatcg gcagagaatc aaaatacatg ctgtggacag
      601 accatttatt atgcggcgtc aaataattga ggacgatttc ttttccctct tgatcaggcc
      661 gcttgctcag aaacgggcga tgctgaagga tcggtttgaa tgtcgccatc gtttcaccga
      721 attccatcat cagttcatga tcgacataat aggattgtct gcctgtcagc gtccgccacg
      781 gaattaattt ttcaacattc gttgtaaacg gcgaatacct gcgccctcct ttttcagagc
      841 cggaaaacgc tggagacgtg atcaccgttt tcggctgggc tgtaatttgt tcgaacgtaa
      901 agcattcctc ctcgcgttct tccgccaggt ctttcagctt caggttcgtg atgttttcaa
      961 gtgattccca tgctttgacg gcgacctttc cattcgaagt ggatgatagg gttaaaatcg
     1021 cttctgcagc ctgctttgct tcacttatat ttggacatcc ctttgcgaca ctgtccgagg
     1081 tgatttctcc caatctctgt ttgagtgatt catattcatc ggctattgac cagctcatcc
     1141 cttttgttcc gctcggcttt aaagcaacgt tcggaccgaa tgcggtcatt ttatgaaaaa
     1201 tgtgtttgta atcccgttca acgacttgga tgttcggcat cgtttttccc ggaatggctt
     1261 cacattcacc tttgctccag tcattgattt tgccgaatgg ctgggccaat tcctgcatgg
     1321 tgtcgtggag gagcggcgtc gcaaccactt ctttcaccgg ctccataccg acttcttctg
     1381 ccagatcgga aacggctttt gacagcgcct tgaaaatatc ccagtctgac ttcgattccc
     1441 acggagccga gatcgcagga gcaaatggat gaatgaacgg atgcatatct gtgctgctga
     1501 gatcatgttt ttcataccat gtcgccgccg gcagcacgat atcggaatac agcgccgtac
     1561 cggccattcg gaagtcaaga ttgattaaca agtcgagctt tccttccggc gcctgctccc
     1621 gccatttgat ttcttcaggg cggatgctgt cgctgtcgtc attcatcaag ccgtttgtcg
     1681 tccccagcaa atgcttgaga aaatattcat gcccttttcc tgagcttgag atcagatttg
     1741 cccgccatac gaaaagattt cttgggaaat tcacttcatt atcaggatct tcaatcgcga
     1801 atttcagttt tttctcttgg agctgtgagg ccacgtacgc accaacgtct tcgggtgttg
     1861 ctgcccctgc tttttcagct tctttataca gatcgatgcc attttgattg aaagtcgggt
     1921 aagacggaag ccaccccagc cgcgcggcca gcacattgta atcagcgtgg tgcttgtagc
     1981 gggatgacgc agcaatcggt gatgccaaat cactgatcgg ctggtcctca taacgccact
     2041 gatctgtcgc aaagtagaaa aatgaggtgc cgttttgcag cttgggcacg ccctcccagt
     2101 cctttgcagt tgcaatcgtc tgccaccctt cagcaggtcg gagcttttcc tgccccacgt
     2161 aatgggccca gcctccgccg tttacgcctt gggcgcctac aagtaaaaca agatttaaca
     2221 ccgctcggta gatcgtgtcg gagttgaacc agtggttaat gccggcccct acgataatca
     2281 tggaccggcc gtctgtatcg atcgcatttt gggcaaactc tctggcaatc ttaacgacag
     2341 cttctttttt gattcctgtc atttgttcct gccaggctgg cgtaaacggc tcaggatcat
     2401 cataggagac agccgatcgt tcgccgatac cccggttcac gccgtagtta gccagtatca
     2461 agtcaaacac ggtcgtgatg tacgtttctt caccgttcag gttcattttt ttaataggta
     2521 gatcccgctc gagcactttg tttccgtcat ttgaaaaata cgggatgcgc accgtgccga
     2581 tttcgtcctc tattcccagc acagagagac ggggttcaat cggttccccg gtttcttcat
     2641 caatcatgtg caggttccat ttctgctgcc cgtcccagcg cgatcccatt gtcccttggg
     2701 gtatggcaaa tgaacttgtt tgttcatccc aaaccgcagg cttccactga tcatgctttg
     2761 tctgccgccc gatgtccttc gcatgcagaa accgtcccgc tgtgtatacg ccattttctt
     2821 ttgacagggt gacgagaaat ggaaaatcag tgtattgctt cgcgtactca ataaaacgtt
     2881 cagtttcttg gttcacgtaa aattcctgca gaatgacatg acccatcgcc atcgcaagtg
     2941 ccccgtcagt cccttggcga atactcagcc agtcatccgc gaactttgag gattccgcaa
     3001 aatccggact gatcgaaatg accttagcgc ctttatagcg ggcctccgcc aaaaaatgcg
     3061 cgtcaggcgt tctcgttaac ggaacgttgg agccccatgt gaggatatag ccggaattgt
     3121 accaatcact gctttccgga acgtccgtct ggtcacccca aatttgcggg gatgctggag
     3181 gaagatccgc ataccagtca taaaaactga gcatagggcc tccgattaac gacataaacc
     3241 gggagcctga tgcatggctg atcatggaca tggccggaat cggagaaaaa ccgacgtttc
     3301 ggtcaggccc gtatttcatc actgtataca gcagagaggc tgaaatcagc ttcagcacct
     3361 ccggccattc agcgcgcaca aaaccgcctt tccctctcgc ctgtttatag gacttcgctt
     3421 tttcaggatt ttcgacgatc gatttccagg cgtccaatgg attttgatgc gcctgcaatg
     3481 cctcccgcca caaattgatc agcacaccgc gcacgtatgg atatttcaca cggagcgggc
     3541 tgtagatata ccatgaaaaa ctggcccccc gcgggcagcc tctcggttca aaatcaggca
     3601 tatccgggcc tgttgatgga taattcaaat tttgcccttc ccacgtgaca attccgtttt
     3661 tcacataaat attccagctg caagaccctg tacagttaac gccgtgggtg gagcgaacga
     3721 ctttgtcgta ctgccatctg tttctgtata cattctccca atcgcgatct tcgcgggtgg
     3781 tttggctatg tttatttgaa tggtgttcga taggagagaa ataattcaat ctcctaaaca
     3841 acggactcct tttctttttc ttcatgagag ttcactcctt ccgagtcagg tgatgctaag
     3901 ttcactataa acagagacag cgtgtttcct tgtgaactat gtcacacact ctgctttttt
     3961 cacaaaatgt tcacacaaag gagaaggaag gcttttcaca ggatgtgagg aaggctgcgt
     4021 tcaggcagaa cgcttgggtc attagctgcc tttcattcaa agatcaaaaa aaaccggctc
     4081 tatttaagaa ccgggctcgg cgttttcatc ctgtgatgta tgcagatacc gcaaaaataa
     4141 ttgataggaa caaaaaacat tttgctgaag catagccaaa aagttcattt gcagctgcgg
     4201 atgataagac atcattttct taaatatgta atatgggatg ttgagaatca gaatgtctga
     4261 agtggcattg actgagataa agggcgataa ataaagcccg cctttttcat caatcggaaa
     4321 cacatcgcct ttttcccaca gcgcaacggt tttcgaccct tcagggagcc ttgtgtccat
     4381 aaaacggaca ctgcctttta atacaatata aacagattga gaatgaagaa aagatggaga
     4441 ctgatcacat gaaccgcgga taaacgtgcc gtttttcagc aaggtttcga caatggatag
     4501 aggcacttca ttaaacatag gaagttgttt cagaaataat aaatagtcac actgattcat
     4561 aggaaaacct cctgtgctaa ggatagcttt agtgtagctc gatcgagcct gtacagcagt
     4621 gatgtatttc acagcctgta tgatgaatgt cacttatcag gagggtgact gcatttataa
     4681 tgaaagaaaa aaggaggatt tcgatgaagg cgctgattcc gaagcagcac ggcgcgtggg
     4741 cgatgctgct gatcccattt ttactcggca tggtcaaggg aggccccgtt atttggcata
     4801 ttccgctctt cctaggctgg cttttcctat acttagcggt ttatcccgtt acgcttgcct
     4861 taaaaaagaa acaaagcaaa ccatatcaaa agtggatgtg ttattacggt tttcccgcct
     4921 gctgcttttt gatgatctcg gtctttcata agccgcctct catctgggtg ggcgtttctt
     4981 tactgccgct gtttctcata catatgtatt ttgcccgcag aaaaaacgaa cgagccttat
     5041 tgaatgatgt tgcaggtgtc ttgttctttt gttcgggcgg gtttgcgagc tgctggctgg
     5101 ggatgggaac ccttgacggc tgggcttggt ttattttctt gcagtctgct ttatttttta
     5161 tcgggagttc cttttatgtg aaatcggtga ttcgtgaaag aaaaaacagg acatttgcat
     5221 actggtcatg gggatatcac ctgctgctcc cctttttatc cgctcttttc ggagcaggat
     5281 ggtcgtttct cgcttttatc ccgagcagct tgcgggcatg gttttttcat ggaagggatt
     5341 ggcccgtaaa aacgattggc attctggaaa ttgtgaatgc ctgcttcttt cttgccgtca
     5401 tgtgcctgtt tatcacaagg taaaaaaaca aggacaccgc tgtccttgtt tttttcagtc
     5461 aatattgcaa atctccagcg ggcaattttc acactcaatc tcacatcgta aatagtcccg
     5521 cttgtgtaaa ataatttttc cggattcgtc tatcgaaata accccttttt tgcggagatc
     5581 tccgagcata cgattgacgc tttcacgtgc agccgcgcaa aactttgcca aatcctgatt
     5641 tgtcaggaca atgttaatca gaatgccgtc gcttcgctcc actccgtagc tgtttgataa
     5701 acggataagg gtggaataga gcgccccctt tttgccatga agaagcagat ccctgatttt
     5761 ggactgaatc ttccggaggt gcgtgctcat ccatttcatg aactcaaatg tcaaagcgcc
     5821 gttttggatt aattcttttt ccagcttatt tttattaatg acgagcacct cgccatcctc
     5881 tagcactttt gcactgagca tataccttgg ttcttcagtg aaaagtgtta attctccgac
     5941 gatatcatgc ttttggcaga ttctaagcgt caggtctttt ccatcagatg tcagcttgcc
     6001 gatttcaatg agtcctgatt gaatcagata aagctcttct gcatccattc cttcccgaaa
     6061 caaatacgtg tgtttttcca tttttctttt cgtgctgatc gattccagca gttcatgcag
     6121 atcgctggat ataagatcac tatcagatgg tcgaacagag agaaaattca tgagctcacc
     6181 tcgaagaaag tcacgttgtg tgtttattgt aacgtgaatt gatttgtacc catcgagaaa
     6241 aaactaacaa tcttgtgaat gccccagtgt tagttgatgc tctggctgtt tctctccgtg
     6301 tgtgttttca ttctttcctg ccaatacatc catatgacaa ggacaaaact ggctaacgcc
     6361 acctctgaaa gcgccataaa cccgatcgcg tactggcctg ttgcctgaaa cacactcgcc
     6421 aatatgagcg gaggaaaaaa gccgcctaat ccgcccatgg cagacacaat cccattggca
     6481 atccccgctt gcttggaaaa atagaaaggc accagtttaa aaacagtccc gtttcctatg
     6541 cctgagcaga cggccacggt taatgatcca aacgtataaa ggccaattgt cggtgagaac
     6601 gataggataa tgcctgataa tgtaagcccg gcaaaaacaa acatcaagat gcggagcggg
     6661 ctcattttat cagccaggaa tccgcctgca ggcctgagca gcgtagaaac cgcaataaag
     6721 ccagccgtcc gcaagccggc atctgcagga ttcagcccaa aatgctccac cagaaagttc
     6781 ggcagataga tagtgaaggc gacaaaggca ccgaacgtaa taaaataaaa caggctcaga
     6841 aaccatagca catgattccg gtaaacggct ttgatttgag tcttaacaga aactttgacc
     6901 ttcttctcat gcctgtcacc gaacaaaacg tgcagtaagg caaagacagc cagcaaaacc
     6961 agatacatct gcacggttga tttccacccg acggcttgag cgataaccgg cgctgcaaat
     7021 gtcgtaacgg ctgtcccgat atttcctgca ccgtaaatcc cattgacgac accgtgcttt
     7081 tctttcggat aatatttcgg gagggaggtc accccaatgg aaaacaccgc tcccccgatc
     7141 cctaagaaaa agccgcctgc gattaaatca aacagagaat ccgcgatact gatccaaaat
     7201 acaggaaata aaagcaggat gaagctaacc ataaacatga gccgcgcgcc aaacctgttc
     7261 gttaaatacc ctaaaggaat gcggagaagc gacccgagga tcacaggaat cgccgtcacc
     7321 aaagaaatct cacccttgct taaatgaata tctaatgtga tttgggaaat gagtgatgaa
     7381 atcagcaccc aaaccataaa ccctgccacc aagcttaatg actgtaacga taattgaatg
     7441 tgttgacggt tgatcatttg gcttgcccct ttcaatgatt caataatcag tcttatcata
     7501 caaaaactag ccaaacagga ttgtgaatta catcacacgt ttttctcata aaaaaaggac
     7561 aaagcccgaa gactttgtcc ttttgatcgt gattacattt tttccggagc cgatacgccg
     7621 atcagctgaa gcgcattgtt cagcgtaatt tgcgttgcct tcattaaagc caggcgcgcg
     7681 cggcttttct cttcattttc agggtcgatg actttctctg cgttgtagaa gctgtgcaga
     7741 gcagaagcca gatcataaat atagttagtg acacggtgcg gaattcgttt ttccgctgct
     7801 tccgccactg cctctgggaa gccgccgatc gttttcagca gatcgtattc tttttctgat
     7861 tgaatatggc tgaaatcaag atctgccgcc ggtttaagcc cctgctcttc cccttggcga
     7921 agcatgctgc aaatacgtgc atgcgcgtat tgtgcataat acacagggtt ttcgttagat
     7981 gttgatacag caagatctaa gtcaaaatcc atatgggtgt ctgcacttcg cattgcaaag
     8041 aagtaacgca cggcatccaa gccgacttct tcaatcaggt cacgcatcgt tacggcttta
     8101 ccggtccgtt tgctcatttt cattttctcg ccgtttttgt aaaggtgaac gagctgaatg
     8161 atttctactt caagcgttcc tttttcatac cccagcgctt cgattgccgc tttcatacgc
     8221 gggatgtagc cgtggtgatc ggcgccccaa acgttgatca gcttatcaaa gccgcggtca
     8281 agcttgtcct tatgatacgc gatatcagga agcaggtacg tgtacgtgcc gtccttcttg
     8341 atcaatacgc ggtctttatc atcgccgaac gtcgtggaac ggaaccaagt cgcgccgtct
     8401 tcttcataga catggccttt ttcgcggagc gcttcaagcg ccttgtcgat ttttccattt
     8461 tggtacagtg aagtttctga ataccacaca tcaaacggca cacggaagtt ttccaagtcc
     8521 ttgcgaagct tttccagctc gtatttcagg ccgtattcac ggaaaaacgc gaggcgttca
     8581 ctttcctctt cgttaacgaa acgatcaccg tattcctcag cgagacgctt tccgatcgca
     8641 atgatatcct caccgcggta gccatcctcc ggcatcggtt tttccaatcc gagtgcttca
     8701 aagtaacgga cttcaacaga aagcgccaga ttgttgattt ggtttcccgc atcgttaatg
     8761 tagtattcgc ggcttacatc gtaacccgct tttgaaagca cgttgcacaa ggaatcgccg
     8821 acagccgccc cgcgcgcatg cccgaggtga aggtctcccg tcggattcgc tgatacgaat
     8881 tctacctgaa ctcgttcacc gtttccgatg ttcgtttccc cgtatgcttc ccctgcttcc
     8941 agtacagacg gaatcagctt tgttaaatat tgattgttca tatagaaatt gataaaaccc
     9001 gggccggcga tatccagttt ttcaatcgaa gccttccctt tatcaaaatg ggcgacaatc
     9061 tcttcagcga tttgacgcgg cgcttttttt gccactcttg ccaactgcat cgccatattc
     9121 gttgagtagt cgccgtgtgt tttatctttc ggtgtttcta aaacaacatt gggaatctgg
     9181 ctttcttcag ccagtcccgc tttcagaacg gccgctttga tttcttcttt cagcacgtcc
     9241 ttcatttgtt ccgcaatgtt catgcgtgag ttcctccctc atacgtgatc gtcatattat
     9301 gtaaatgctc ctgctcgtct ccgacatgca tgtcatatgc gatgctgata cggccttttt
     9361 cttcatcgag atcagattga atcgattttg tgcttgtttt cagctcaagc tcaccaaatg
     9421 acattttata tttagcaatt gtggaagctc ccgttacgaa acgctgattc attttgacag
     9481 cgcctgacct catgaccagg acttcgcctt cgcttacttt cacaatcgtt ttgactttgc
     9541 ctaagtcgtg ttcttcataa taagatagat acactttatt ttgttttaca tagtaaaatc
     9601 cggtggtgcg gaattcgatg acttcttggt ttccgtcatc ctcgatcaca gacttcacat
     9661 ggagtgttat cggtgtctct tgcttcattc tgacacgtcc ttttcatcat tccactttga
     9721 cttgaatagt ataatcattc ggtttgtaaa cttcaactgc ttctatctta ccatcattgc
     9781 tcatcagatt tgaagataaa cctcataaaa agcatttcct tatatagaag agaaaatcat
     9841 atcactaatt acctttagga aatgttacat ttttccgaaa tctatcattt ccttttcaca
     9901 tttttttcaa aatatatgta ttgaattagt aatttgatag ttttaagata aaagtacaac
     9961 atagatctgc tagaaaaaca aaaaaaggga ggattcaatt atgaaaaaag ctgtcattgt
    10021 agaaaacaaa ggttgtgcaa catgctcgat cggagccgct tgtctagtgg acggtcctat
    10081 ccctgatttt gaaattgccg gtgcaacagg tctattcggt ctatgggggt aaggatctcc
    10141 caaaagggca tagtcattct actatgccct ttttaagtaa attacaattt ttaactaaaa
    10201 tctacctctt ggatatacat acacaaccgt ttttcatttg aatcatatgt ataggggatg
    10261 gtattttgtt tatagagcag atgtttccat ttattaatga aagtgtaaga gttcaccagc
    10321 ttcctgaggg cggcgtgtta gaaatcgact acttgcgcga taatgtctcc atttctgact
    10381 ttgagtattt ggatctcaac aaaacggctt acgagctctg catgcgcatg gatggccaaa
    10441 aaacagctga gcagatttta gctgagcaat gtgcagtgta tgatgaatca ccggaagacc
    10501 ataaagattg gtattacgac atgctcaaca tgctccagaa caagcaggtt attcagcttg
    10561 gaaaccgggc cagccgccat acaatcacca cgagcggaag caatgaattt ccgatgcccc
    10621 tgcacgccac ctttgaactg acgcaccgct gtaatttgaa atgcgcccac tgttatttgg
    10681 aaagctcacc tgaagcgctc ggcaccgtgt cgattgagca attcaaaaaa acggctgata
    10741 tgctgtttga taacggtgta ttgacatgcg aaatcacagg cggagaaatt tttgtccatc
    10801 caaacgccaa tgagattctt gactatgtgt gtaaaaagtt caaaaaagtc gctgtcttaa
    10861 caaacggaac actcatgcga aaagagagcc tggagctttt gaagacttac aagcaaaaaa
    10921 tcatcgtcgg catttctcta gatagtgtca attccgaggt ccatgactcc tttagaggga
    10981 gaaaaggctc ttttgcccaa acttgtaaaa cgataaaatt gttgagtgac cacggtatat
    11041 ttgtcagagt cgctatgtct gtcttcgaaa aaaacatgtg ggaaatccac gatatggccc
    11101 aaaaggttcg ggatctcggg gcgaaggcgt tttcttacaa ttgggttgac gatttcggaa
    11161 gaggcaggga tattgtccat ccaacgaaag acgccgagca gcaccgcaag tttatggaat
    11221 acgagcaaca tgtgattgat gagtttaaag atctgattcc gattattccc tatgagagaa
    11281 aacgcgcggc aaattgcggc gctggctgga agtccattgt gatcagtccg ttcggcgaag
    11341 tacgtccttg cgccctcttt ccaaaggaat tttcattggg aaatattttt catgattcct
    11401 atgaaagcat ctttaactcc cctctcgtcc ataaactgtg gcaagcgcaa gcgccgcggt
    11461 tcagcgaaca ttgcatgaaa gacaaatgcc cgttcagcgg ctattgcgga ggctgttact
    11521 taaaagggct gaactctaac aaatatcacc ggaaaaacat ttgctcttgg gcgaaaaatg
    11581 aacaattaga agacgtggtc cagcttattt aggagggaaa cgatttgtca ccagcacaaa
    11641 gaagaatttt actgtatatc ctttcattta tctttgtcat cggcgcagtc gtctattttg
    11701 tcaaaagcga ttatctgttt acgctgattt tcattgccat tgccattctg ttcgggatgc
    11761 gcgcgcggaa ggctgactcg cgatgagcat tttggatata cacgatgtat ccgtttggta
    11821 tgaacgggac aacgtcatct tagaacaagt ggatttacat ttagaaaaag gcgccgttta
    11881 cgggttactt ggggtaaacg gcgccggaaa aacgacactg attaatacgc tgacaggcgt
    11941 gaaccgcaat ttcagcgggc gttttacact gtgcggaatt gaagcggagg ccggcatgcc
    12001 gcagaaaaca tcagatcagc tgaagactca ccgttacttc gccgccgatt atccgctgct
    12061 atttacagaa attacggcga aggactatgt gtctttcgtc cattcgcttt atcaaaagga
    12121 tttttcagag cagcagtttg ccagtttggc cgaggccttt catttttcga aatacatcaa
    12181 taggagaatt tcggagctgt ccttggggaa caggcaaaag gttgtattga tgacaggctt
    12241 attgctgcgc gctcccctgt ttattttgga tgagccgctc gtcggtttgg atgtggaatc
    12301 gatagaggtc ttttatcaga aaatgcgtga gtactgtgaa gcaggcggaa ccattttgtt
    12361 ttcttctcat ctgctcgatg tcgtgcaaag attttgtgat tatgcggcta ttcttcacaa
    12421 caaacagatc caaaaggtca ttccgattgg agaggagacc gatctgcggc gggaattttt
    12481 cgaggtgatc ggccatgaat aacataatcc ctatcatgtc tttgctgttc aaacagcttt
    12541 acagccggca agggaaaaag gacgccatcc gcattgccgc aggccttgtc attctggccg
    12601 tgtttgaaat cgggctgatc cgccaggccg gcattgatga atcggtgttg cgcaaaacgt
    12661 atatcatact cgcgcttctt ttgatgaaca catatatggt gtttctttcc gtgacatcac
    12721 aatggaagga atcttatatg aagctgagct gcctgctgcc gatttcttca cggagctttt
    12781 ggctcgccca gagtgtcgtt ttgtttgtcg atacctgttt gagaagaact ttattctttt
    12841 ttattttacc gctgttctta tttggaaacg gaacgctgtc aggggcgcaa acattgtttt
    12901 ggctcggcag gttttcgttt tttaccgttt actccattat tttcggagtt gtgctaagca
    12961 accacttcgt caaaaagaag aacttgatgt ttctgctgca tgcggcgata ttcgcctgtg
    13021 tatgtatcag cgccgctttg atgccggccg ccacgattcc gctttgcgcg gttcatatcc
    13081 tgtgggcggt ggtcattgac tttcctgtct ttctgcaggc gcctccgcag cagggcaaga
    13141 tgcattcatt tatgcggcga tctgaatttt cgttttacaa aagagaatgg aaccgattta
    13201 tctcttctaa agcgatgctg ttaaattacg cggtaatggc ggtattcagc ggcttctttt
    13261 cgttccagat gatgaacacc ggcatcttca atcagcaagt gatttatatc gtgatttccg
    13321 cgcttttgct catctgctcg ccgatcgccc ttttgtattc gattgaaaaa aatgaccgga
    13381 tgctgctcat cacgcttccg atcaagcgaa aaacgatgtt ttgggcgaaa tatcgctttt
    13441 attcaggcct attggcaggc ggatttctcc ttgtcgtgat gattgtgggt ttcatcagcg
    13501 gccgttcgat ttcagttctc acttttttgc agtgcattga gttgctgctg gcgggagcgt
    13561 atatcaggtt aactgcggat gaaaaaaggc cctccttcag ctggcagacg gagcagcagc
    13621 tatggagcgg tttctcaaaa tatcggtctt atctgttttg tcttccccta ttcttagcca
    13681 tattagccgg caccgctgta tccttggcgg tcattccgat agccggtctg gtcatagtct
    13741 attacctgca aaaacaggat ggtggtttct ttgatacaag caaaagagaa cggcttggaa
    13801 gttaacctgc tgaagactca tcaattttca actatttcaa tcgccgcgag ctttctgaaa
    13861 ccgatcgaaa gcgcggcgga acctgaggaa gaaacgattt atttttacgg cgccgccgca
    13921 tacctgaagg agcaaatcat tgacgctttt ggttatgctg ccggcagccg tttcatgtac
    13981 tcagcgaatc tcttttttga tcagcagctg aaaacctgcg ggacccgttt gattcaccca
    14041 ttatataacg ggaatcttca tgttgacgcc ctgatgaaaa cttttgcaga cttgtctttc
    14101 ccttcttctc tttcattcga agcatttgaa aaggccagga atgagctgct gctgaaaatc
    14161 gaaaagaaat tcactgatcc cttctcctac tcggcggctc gcttggctga ggaggtcttc
    14221 ggaaacccga tgtacggcac aggcatgttt ggccggaaag acaggataaa ggcgattcat
    14281 cctaaacggt ttctcgacgc aacggacttt atcgttgatt tagtgtccca gcaaaaacag
    14341 ctgaacatat tgggacaagt acaagcatgt gatgttcggg gacatgcccc gcaaacgtcc
    14401 gctgtaacgt ccggaagaat acccgtaaac cggcatgttt ttgaaacaga gacacgcagc
    14461 gctgcaggtc cttccgtctt gacactcgga tttgactgcg gagagatgaa agatgccagc
    14521 gattatatca aaatacagct aatagacgga ttactgggaa agtacggcca ttccgcttta
    14581 ttcaagcact tcagagagaa ggatctggca gtctatcacg ttatcacccg ttacgatgtc
    14641 atgaacaatt tgctgcttgt ttcaatatgt acagatcagc ttcatgagat agacattccc
    14701 ccgcgcgttt tggaagctgt ctcagctttt catacagatg agcgggaact agaacaggca
    14761 aagcagtttt tacgcaatga attgctgctg caattcgatt ctcccgaagg tctattggcc
    14821 tatatgggga tcctgcgccg cttctcctgc acgaaagaag ccttgctgga tggcatctca
    14881 gcggttacat gccgtgatgt attgcaattc atagcgacca tcaattatat cggagctcat
    14941 gtagtaaggg gatgaagaga tggaaaagaa agcctttttt caacaactgg atgaacgaac
    15001 cgatatcaga tacacagaca gcggactaaa aatattcaga ttgaaattcc cccgcgccca
    15061 cctgcggctg tgcaatgtaa aaatcgattt tggaagccgg gatgtatgta tacgggcaga
    15121 atccggtgat acactgcttc cgtatggcac agcgcatttt ttagagcatc ttctcttctg
    15181 gcataacggc cgcaatctgt acagtgattt ttttgcgcat ggcgcgcttt taaacgcatt
    15241 cactacctac accgatacca atttcatgtt tacctcatta ccggatcggc tcagacaaac
    15301 gatccccatc ctgcttgatg ctttatggaa ccactcattt gacaagaaga ttgtcgctca
    15361 ggaaaaagct gtgattacaa gcgaaattca aacagcacac cttaaccatc agctctcata
    15421 tcattatcag ctgatcagca tgctttctcc ctcctcacca gctgccgttt tccccgcagg
    15481 cagaatcgaa gatattgagg cgctggacat cagtgattta caaaaagcct ataaggctgc
    15541 ctaccaagcc catcggatga cactgttttt gattgggggc tcagaaaata cagaaacgct
    15601 tttgcctcct cacctccagc tggaaaagcg tccggattat catgctgaaa gaaaaatcat
    15661 cccggcatgc cctccagccc tctcacaaaa aatggtgctg ggtgatgagg agcggatgga
    15721 agatacttgg accggattac agatcggcgc acttcccggg caaaacgatc tgttgtcgat
    15781 aaagctttat tgggatatcg cggctcgtat tctatttcaa ttagattcac cgttttttca
    15841 agagattcag caaacgtacc gtctggaaat cgatcgcttg tcagccgaga cttatatata
    15901 tgaggatggc ggtttcttga tccttcacag tcaagggacc cattcttcag cttatatcga
    15961 tgtggcttca tactatgtca cacagaagaa agaacaggtt gccgcctggc ttcaatacgg
    16021 caaggactct ttgacagacg cgatcattta tgacagcgat tatgtgcgta aatgcttcga
    16081 gtgggcagcc gagtgtgaca ggtgcgattg ctcgtttctt gacatgtacc acatcattca
    16141 agatatggat gcgcaggttt tcttgtctct cattgatgca atggcatctt ctaacaaagc
    16201 gatcattcat gtttctcaga aagaggcgat cagacaatga taaaaaacac tgtctttacc
    16261 cttttattgc tgcttatagg tatggcggct tattccttcg gctgggttca ggtcgtggcc
    16321 gaagccgccg cccaatatgt acagatgatc aacaatgacg ctgtgcggct cgggctgctg
    16381 gcttgtaccg ctgccctcct gatgctgcct gcttttctct atcttcatta tgtcacccaa
    16441 tccgtgaaaa acatgacagc agcttttcag aaactcacac agtctcatca aagctgctgt
    16501 gactttcagc aacacaactt gtgcagccga tatgcagaag acgtcaaatc gctgcgtgac
    16561 agctataaaa acgtccgcca aacatacgtg atggctgccg tgttgtgcca agtcttcata
    16621 ttcggctgca tgttcgaaat cgttaaagcc gtccctttcc gccttcacac gccccctgcc
    16681 ttttcaatgg gacttgcgat gctactgatc ctgtatttat tgttttgcat gcgaacgtat
    16741 ttgcggcagc ttttccggca cggcagcctg ttcagaaaag tgtttgcggg agtgctggca
    16801 gcagccggga tttggtggat gctcagtttc tctataagtg aactgctgtt tctgattatc
    16861 ctggctgcca ttcagcaaat cggatcattt atttataaac gattctctta tcgcagcacc
    16921 gcttctcttg atctataaaa tagctacatc gcaatcgcag acggacccgc gccaaccgga
    16981 atcaccgtca cggctgtata atcacttgtg cagtacacgg tcacagcatt gtcgttgggc
    17041 tgtgccgcat aaatatactg tttgtccggc gttacggcga ggtcaaaagc gccggggaga
    17101 gacacgtttg caatgatcct ctgtctggcc gtattaacta catataagtt attaatgaga
    17161 aacggttcac tatatggctc tagaaaataa gctctagtac tatcgagaga aaatacaatc
    17221 gtcctcagcg tttcaaataa acggctgaag tcccctcccc tgcttaatgg tgacaaacta
    17281 atctccgtta cacctttcgg ccacagctca ccattcaata cgtacgcaaa atttccagcg
    17341 taaggagttg caattaaact gggaaattca aatgtatcta tgatactttc taccaactgc
    17401 ccagtattta catcatattt atcaaccgac caactgcttc cattagcggt atagacatac
    17461 tgtccattcg gatcaagagc aaagtctaaa gcgccgggta tcggaatgac atcaatgacc
    17521 gattgagagg ccgtgttaat cacatatata gatccggcgg ccatcacgta tgcgaactca
    17581 tctgttggat caaattcgat ttttctcggc cctcctccaa cagtaatggt atttatgata
    17641 gttaatgttt tattatcaat cactgaaaca aggttggtat ttccatggag gatatacgtg
    17701 aatgctttat cgaaagtaac gcctagatta gttggcacag cagaaaacgg gattgttttt
    17761 acaacagtgt ttaaatctgc atcaatgacc gaaaccgtgc tgtctccagt attggcagta
    17821 aacacatatg attgagggtc tggcgatggc ggtaaaacaa gtgtcccggc caccgtaagc
    17881 ggactgccgt agaaaggcgg tacaatgaga agatcttcca ctatcatttg actaaaatca
    17941 ggacagcggt cagactgtgc tgcataataa acaacttgat caatctcttc ggtatgaatc
    18001 accgaaacag ccccgtctcc ttgtccatat tgatttcgta caggcgacac actgacaaga
    18061 agcgtaatgg tcccttgtac tctcacggca tatcgaacac cgatatcttc tggttccggc
    18121 ccagtctgga ttaagcaagg ctcactgata caggacaaat tgtctgtact ccatgtaaca
    18181 gccgctgacg cttctgccga atcaaccttg aagccctcag ggatatctat cggcacttga
    18241 aacggcgctt cccggctaat ttcctcatca caaaaacaga aacaattttc ctgtaaagca
    18301 gaaagatcat tctttttcat gatttcacgt ccttttagaa atgcacaaca tgcagcggtt
    18361 aaatcgtaat ggcacccggt gaaaccccaa gagatatcac agtttcctca gaataatcat
    18421 ctgtgttgta aacaatgatg ctctgctcta taaaacgagt tgcatacaga aaatcgccat
    18481 tcggggtaaa cgcatagtct gttgctgatt gcggaagatt tccaattaca cctgctccat
    18541 tcggactgac agaatataaa ttgccagtga agctgtcatg taaatacacc tctgatccac
    18601 tcgtaaacat tacatatagc ccgtcaggct ccagctcttg ggtatccctg atcgtaaacg
    18661 tatttaaatc aataaccgtc aaataattga ataagaattc ttgttctaat acatacgcat
    18721 accgctccgt agaatctgtt tctatggatg atacgataag ctctcgttca atcgttccta
    18781 agacttcacc ggtagataag tccacttttt gcactaaccc aaaattaaga acataggcga
    18841 acaacccatt ggggtcaatt gcaatatcaa aaccttctac aggaatagac ctctcaacag
    18901 tcaacgtatc aattccaatc acataaatgg cagtaccggt gaaaacataa gcaaactcat
    18961 gattagggat aaatctaatc aatcgaggcg gctgatccag caatatagtt gctgtcactg
    19021 ttaatgtgtc ataatcgatg acagaaatca cattattgtt gggatgtaag acaaacacag
    19081 cgcttttatc tggcgtaatt tcaatacctg ccggattgta cggaagagca atcgttgtca
    19141 caacagtatg ggtgtttgta tcaatcacag aaactgattg atcatttgga ttcgctgtaa
    19201 acgcgtagac gggttccggc tccggtacaa gcacaatcgt ccccgtcacc gataaaggac
    19261 tgccgtaaaa cggcggaaca acaacaaggt tctcaatcgt gatgtcactg atatccgggc
    19321 aatcatccgg ttcatcggaa taatagacga cttgatcgat ttctgcattg tgaatgacgg
    19381 aaacagcccc gtccccttgt ccatattgat ttcgcacagg tgagacactg acgagtagcg
    19441 taacggttcc ctgcaggcgc actgcaaatt gaacaccgac ctcatcaggc tctggccccg
    19501 tttgaattaa gcaacggtca ctgacacaag aaaggctgtc tgcattccac gtcacgtttg
    19561 caacagcttc agccggatca acgacaaatc cttcaggtaa ttcaatcggc gcttgaaaca
    19621 tggcttctcg gcttgcttct ccctcacaaa aacataagca ctcttcttgt tctgctcctg
    19681 ctttttcttt aaaggaaagc ttattttttc tcattccttc acttcctttt cagacataca
    19741 ctgctcacgc agatataaca gaatatggaa gatcaacgtg tttgcttgta caaattactg
    19801 agggtaaacg cttctttttg aaaatatatc tccaaacatg cggtgtaacg aaagaaaaaa
    19861 ttgcggtttt tttgcgcttc tcacaagaat gttgatgata aaatatgaca tatatagaat
    19921 tatgaaggga gggatttgca aacgtgacag gtgtcatatc ttcttcttcc atcggagaaa
    19981 agattaacga atggtatatg tacatacgcc gattcagcat acccgatgca gaatatttgc
    20041 gacgagaaat caagcaagag ctggatcaaa tggaagaaga tcaagacctt catttgtact
    20101 attcactgat ggagtttcgg cacaacctaa tgcttgagta ccttgaaccg ttagaaaaaa
    20161 tgaggattga ggaacagccg agactgtctg atctgctgct tgagattgat aaaaaacagg
    20221 ctcgtttaac tggtctgctt gagtactatt ttaatttctt cagaggcatg tatgagctgg
    20281 accagcggga atatctgtcg gctattaaat ttttcaaaaa ggccgaaagc aagctgatat
    20341 tcgttaagga tcggatagag aaagctgagt ttttctttaa gatgtctgaa tcttattact
    20401 atatgaaaca aacgtatttt tcaatggact atgcacggca agcatatgaa atatacaaag
    20461 aaaatgaagc ttataatata agattgctgc agtgtcattc tttatttgcc accaattttt
    20521 tagatttaaa acagtatgag gatgccatct cacattttca aaaagcttat tctatggcag
    20581 aagctgaaaa gcagccccaa ttaatgggaa gaactttgta caatatcggg ctttgtaaaa
    20641 acagccaaag ccaatatgag gatgccataa cttatttcaa aagagcaata gctgtttttg
    20701 aagaatcaaa tattcttcct tccttacctc aagcgtattt tttaattaca cagatccatt
    20761 ataaattagg aaaaatggat aaagctcatg aatatcatag taagggaatg gcttattcac
    20821 aaaaggccga agatgtaata tatttatcag agtttgaatt tttgaaatct ttatacttat
    20881 caggcccgga tgaagaagca attcaaggat tttttgattt tctcgaaagt aaaatgttgt
    20941 atgctgatct tgaagatttc gctattgatg tggcaaaata ttatcatgaa cgtaaaaatt
    21001 ttcaaaaagc ttctgcttat tttttgaagg tggaacaagt aaggcaactt attcaaggag
    21061 gagtgagttt gtatgaaatt gaagtctaaa ctattactct cttgtctggc tctaagcact
    21121 gtgttcgtgg caacaactat tgcaaatgca cctacacacc aaattgaagt tgcacaacga
    21181 ggaatgattt aaccgccgtc catcggcggt tttttcgtcc cctctttacc aaagtctccc
    21241 aatccatgct atgatctttt caataatctt gaagagagtg gaaatgcagc atgtctctaa
    21301 aaagtgtgag aacccacttt actcaatgga atcgagaaaa tgatgtgacg gagttcgaaa
    21361 cgtcgagtgc gacagttgaa caggcagctg agacaatcgg cgtaagcctg tctagaatcg
    21421 ccaagtccct gtccttcaga ggggaaggag atcaggtgat tctgattgtg gcagccggcg
    21481 atgccaagat cgacaacaaa aagtccaggc aaacatttgg ctttaaagca agaatgctct
    21541 ctcctaatga ggtgctggag cagacaggcc atgaaattgg aggagtttgc ccatttggat
    21601 tggctcatga tc
//
