LOCUS       NZ_CP048397            25061 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. S4.7 chromosome, complete genome.
ACCESSION   NZ_CP048397
VERSION     NZ_CP048397.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S4.7
  ORGANISM  Streptomyces sp. S4.7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.
  TITLE     Viennamycins: new lipopeptides produced by Streptomyces sp. S4.7
            isolated from the rhizosphere of Edelweiss (Leontopodium nivale
            subsp. alpinum)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2020) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.8x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010384365.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 10:27:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,027
            CDSs (total)                      :: 6,939
            Genes (coding)                    :: 6,650
            CDSs (with protein)               :: 6,650
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 289
            CDSs (without protein)            :: 289
            Pseudo Genes (ambiguous residues) :: 0 of 289
            Pseudo Genes (frameshifted)       :: 103 of 289
            Pseudo Genes (incomplete)         :: 223 of 289
            Pseudo Genes (internal stop)      :: 23 of 289
            Pseudo Genes (multiple problems)  :: 52 of 289
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:05:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6339817
            Orig. end                         :: 6364878
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048397.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zotchev Lab, University of
            Vienna, Austria.
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25061
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="19"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25061
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25061
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15061](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15061
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(578..988)
                     /locus_tag="SSPS47_RS28290"
                     /old_locus_tag="SSPS47_28700"
     CDS             complement(578..988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009333293.1"
                     /locus_tag="SSPS47_RS28290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28700"
                     /product="VOC family protein"
                     /protein_id="WP_147875035.1"
                     /transl_table=11
                     /translation="MFTAITHSQIYVLDQDAALDFYVGTLGLEVNTDADLGFMRWLTVN
                     VPGHPDRQILLEKPGPPALSEETAREVRELLTKGATGGTLIFSTDDCRGTYETLRARGV
                     EFTDEPTERPYGIDCGLRDPFGNNIRFTQPKP"
     misc_feature    982..995
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.68"
                     /tool="antismash"
     misc_feature    complement(982..996)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.63"
                     /tool="antismash"
     gene            complement(1097..1495)
                     /locus_tag="SSPS47_RS28295"
                     /old_locus_tag="SSPS47_28705"
     CDS             complement(1097..1495)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003984146.1"
                     /locus_tag="SSPS47_RS28295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28705"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_187280128.1"
                     /transl_table=11
                     /translation="MGRDVEESNRRMLRVRDAMDRDYARPLDVPALARIAHVSQAHFTR
                     TFRATFGETPHRYLQRRRVERAMFLLRETDRSVTDICYEVGFGSPATFSRTFHEIVGRP
                     PRTYRKETPRAAGAVPTCFTKAWTRPST"
     misc_feature    2033..2047
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.73"
                     /tool="antismash"
     misc_feature    2093..2108
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.3"
                     /tool="antismash"
     misc_feature    complement(2093..2109)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 28.06"
                     /tool="antismash"
     misc_feature    complement(2094..2109)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 29.15"
                     /tool="antismash"
     misc_feature    2390..2404
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            2456..3568
                     /gene="rsgA"
                     /locus_tag="SSPS47_RS28300"
                     /old_locus_tag="SSPS47_28715"
     CDS             2456..3568
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rsgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018847832.1"
                     /locus_tag="SSPS47_RS28300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28715"
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="WP_164253417.1"
                     /transl_table=11
                     /translation="MSLSTASPEASSASHPLAPYGWDEGWETEFTPYAAQGLLPGRVVR
                     VDRGLCDVVTPGGTVRADTEFVVPRDPLKVVCTGDWVAVDPGGDPRYVRTLLPRRTAFV
                     RSTSSKRSEGQILAANVDHAIIAVPLAVELDLGRIERFLALAWESGAQPLVVLTKSDLV
                     PDPTGLSYLVDDVETTAPGVQVLPVSAATGEGVDVLTAVVCGSTSVLLGVSGAGKSTLA
                     NALLGEDVMEVQATRDVDGKGRHTTTTRNLLVLPGGGVLIDTPGLRGVGLWDAGQGVGQ
                     VFAEIEELAEECRFHDCAHGREPGCAVLAALEDGSLSERRLESYRKLLRENQRIVAKTD
                     ARLRAEIRRDWRLKGAEGRAAMEAKRGRIR"
     gene            3688..5133
                     /locus_tag="SSPS47_RS28305"
                     /old_locus_tag="SSPS47_28720"
     CDS             3688..5133
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037117.1"
                     /locus_tag="SSPS47_RS28305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28720"
                     /product="AlkA N-terminal domain-containing protein"
                     /protein_id="WP_164253418.1"
                     /transl_table=11
                     /translation="MDEETRYEAVASRDARFDGAFFFAVETTGIYCRPSCPAVTPKREN
                     VRFYPTAAAAQGNGFRACRRCRPDAVPGSAEWNVRADVVGRAMRMIGDGVVDREGVPGL
                     AGRLGYSARQVQRQLTAELGAGPVALARAQRAHTARTLLQTTVLPVTEIAFAAGFASVR
                     QFNDTIRRIYARTPSGLRAESGTGGAPATPAAPALAGIPLRLAYRGAYAARAMFDQLAD
                     EALTSVEEVIGRPGARTYRRTLRLPHGPGVVSVDEAPPSTGAPRPGWLEARIHLTDLRD
                     LTTAVQRLRRLLDLDADPYAVDERLGADPLLAPLVAARPGLRAPGTADPAEYALRVHLG
                     GAEARRLVAAFGDPVERPCGTLTRLFPAPAALVDDPVAGPLATALADGTVRLDSGASRE
                     EAERALLTVPGVSARTAALIRMRGLGDPDVAPDGGSGDAAWRPWRSYAVRHLLLGLPAP
                     AISRSPPAPNCESSVDGSGSVLH"
     gene            complement(5066..5440)
                     /locus_tag="SSPS47_RS28310"
                     /old_locus_tag="SSPS47_28725"
     CDS             complement(5066..5440)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118961.1"
                     /locus_tag="SSPS47_RS28310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28725"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_164253419.1"
                     /transl_table=11
                     /translation="MTEFSEAERSYLSSQRLGRLATVDPKGQPQANPVGFFPQADGTIL
                     VGGYALGTTKKWRNLRSNPRVALVVDDIVSLKPWKVRGVDIRGEAELLTGPHELGPHFS
                     EELIRIHPRKIHSWGLEETG"
     gene            5766..7160
                     /locus_tag="SSPS47_RS28315"
                     /old_locus_tag="SSPS47_28730"
     CDS             5766..7160
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSPS47_RS28315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SSPS47_28730"
                     /product="ATP-binding protein"
                     /protein_id="WP_164253420.1"
                     /transl_table=11
                     /translation="MTSPSEPALALGAVTVVMAVVALLLALSRRKQTRRCREMDAALKS
                     AESRTREAETRTRFAESHTRDAEAREERFRAEVTHLVSARLPAVPLHLISSHHPVPGLL
                     NAGEAGPEDAELLDSVLTRVSEMVLKERRRVDAAARAALRGASQDSQALSYRLQSELDA
                     LQREFTGSRHLTHRMLAADHLNEQNLRLIQRTAIVCGAWPGHVRKDTYVAEIVTGASSR
                     LRGFDRIKINSRIASNVGIVGRAAEPVAVACAELMANALEHSRDDLAVDVGLIQSGNGN
                     VCITVDDAGKGMTAEAATRGARLVSADTHDVMLTELGDPPSQGFAAIGRLVADYGFHVS
                     IDHSSPYGGVRAVVTIPPNLLASIDEEAEPPSAMAPQAAVAPKAERRPTSVPETPVDDE
                     KPRTPVPDSADGLPQRRRRGPAAPGAGLAAPTYRAPDPERSLRAWSEFQDGLESGRTGT
                     DLEETQ"
     gene            7163..7576
                     /locus_tag="SSPS47_RS28320"
                     /old_locus_tag="SSPS47_28735"
     CDS             7163..7576
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015232.4"
                     /locus_tag="SSPS47_RS28320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28735"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_164253421.1"
                     /transl_table=11
                     /translation="MPHGENETWYLAPITEIPGVHHALLMTLDGMVQARSENLSADDAD
                     GVAAMTSALHAASRAAVIPALGAAADTPIETVTVKVAEGTYMVMPAGANTLIAAAGDDS
                     MHMGVVVHMMARQAKKLGEQHMSVSARTHDGAS"
     gene            7573..7956
                     /locus_tag="SSPS47_RS28325"
                     /old_locus_tag="SSPS47_28740"
     CDS             7573..7956
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017170.4"
                     /locus_tag="SSPS47_RS28325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28740"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_164253422.1"
                     /transl_table=11
                     /translation="MSRGQHQRRLLPAYLATGGGGGAPLPTTLDTLTALRASGHPFSSY
                     HTSVHRRVVELVTDGSLTAVEIAAYLALPASVGLMLAEQLVSDGLLNASVPIPEALAPS
                     RAGRPSMQLMEEVLSGLQSLRVA"
     misc_feature    7645..7647
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7843..7845
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7967..8548
                     /locus_tag="SSPS47_RS28330"
                     /old_locus_tag="SSPS47_28745"
     CDS             7967..8548
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525552.1"
                     /locus_tag="SSPS47_RS28330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28745"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_147875026.1"
                     /transl_table=11
                     /translation="MYLPEGEHQRVKILVAGPLGVGKTTAIKTLSQIPTLHTDEVMTDA
                     AADADDVSLVGLRDKKTTTVAIDFGRMTLPGDRIVLYLYGTPGQRRFLPLWEGIAFGAL
                     GALVLVDTRRLDESFEVMDLIEERGLPYAVAVNTFPDSPDYDLEIVRKKLDLAPDTPLV
                     TCDAREMNSSLSALIALTAHSISSAGVGAS"
     misc_feature    complement(7986..8001)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.56"
                     /tool="antismash"
     gene            8545..9852
                     /locus_tag="SSPS47_RS28335"
                     /old_locus_tag="SSPS47_28750"
     CDS             8545..9852
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSPS47_RS28335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SSPS47_28750"
                     /product="cytochrome P450"
                     /protein_id="WP_164253423.1"
                     /transl_table=11
                     /translation="MSITPLDVTAVPLHGPEHAADPQRSYELLRRQGPVGVAEISPGVL
                     VHLVTDYQAALGLLQDTETWSKDTRKWLPQVPESSPIRPMVEWRPSLFFADGEEHAHLR
                     KVITDSFALLDPNDVRVLTFRFADRLLQDFADAGTVDLVSQYAQQLPLMVFNALFGMED
                     EHGPRLVGALAAMMDTDPERKASGAQLFGGYLQTLYQAKAEKRGHDLTSWFIDHPNGLN
                     QEEVMNQIIIIFGAGNEPTANLIANTCVRMLSDDRYFGTLTTGSLPVQHAIDEALWHDS
                     PLANYSFHFPKEDVTFHGTRIPAHSPVMVSYAAANTCPHSGVPADGYRSGTKAHLAFAA
                     GPHACPARDLALLIATAAIERLASYLPDIELAVAPDQLTYRDGPVHRTLTSLPARFTPL
                     TPDAKGITPWSRSSAGPRTVTGASSTAGDRMSVTTS"
     gene            10001..11083
                     /locus_tag="SSPS47_RS28340"
                     /old_locus_tag="SSPS47_28755"
     CDS             10001..11083
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957287.1"
                     /locus_tag="SSPS47_RS28340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28755"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_164253424.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7.4e-50, bitscore:
                     168.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTCPAASPPDLMSVRHQVSAALTTFLDAKEEAAPGTELLYLTS
                     TLRAFLTGGKRLRSVLCVYGWHAAGGDGEMTAAIRAAASLELFQVFALVHDDVMDDSDV
                     RRGRPSAHRALAAAYTDNGGPHGRAAAHGLGAAVLLGDLALVWSDEFLHTAGLDPSRLA
                     QVLPLVAEMRSEVMYGQLLDLQTTGRLTGDVETALHVIRYKTAKYTVERPLHIGAAVAG
                     APPAVLDACTAFGVPLGEAFQLRDDLLGVFGDPAETGKPVLDDLREGKATVLMALAVQR
                     ASATERGTLRGLVGRSDLDEDQAAEIRTILDSTGARQSVEEKITARRDEALAALDEAPF
                     PEETTGRLREIALAATERRT"
     gene            11080..12747
                     /locus_tag="SSPS47_RS36065"
                     /old_locus_tag="SSPS47_28760"
     CDS             11080..12747
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024640.4"
                     /locus_tag="SSPS47_RS36065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28760"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_164253425.1"
                     /sec_met_domain="T2TS (E-value: 1.2e-97, bitscore: 326.3,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARPSTVTATVRSNEPVNDTVANATYPEQAARLVAGIDQDPWGS
                     VRPSLYETARVVSAAPWLSGEQRRIAYLLNAQAPDGSWGEGPERYRLLPTLSAVEAALA
                     LLGRGGMSEETTRRLTTAVDSGLAALRALPSAGPWPDTAAAEILVPGLVAKIHERLTHV
                     GDDRTPVVGDWRPGPAPALPGGYDQSVPGYLARRYASAGSLPVKLHHTFEGVAGYIPGA
                     LIPDGPDLLGSSPAATAARAAVSHEPSAGTVAALEAVAERYSGLFPEAAPILVFERLWV
                     AAALAGVDLPPTSVPTVRAWATDLYDPRGVRGAPGLMTDADDTAMAVLVSSLVGLDHTP
                     EPLDLFHNGSHYDCYIGEDTGSVTANAHALHALGSYLRHHPEAQHTYGPRADKLSDWLV
                     GQQRPEGPWPDKWHASPYYATARCVAALSRHGGDRAATAVGTAVAWTLDTQRDDGSWGI
                     WGGTTEETAYAARILLATADPRPRHLRALDLAETYLNEGAGSGEHPALWHDKTLYAPGA
                     MIEAEVLAVRELLRTRHGTAWPGAGRPHPTTREGRTDT"
     gene            12744..14102
                     /locus_tag="SSPS47_RS28350"
                     /old_locus_tag="SSPS47_28765"
     CDS             12744..14102
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000108: Oxidation (67% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="SSPS47_RS28350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28765"
                     /product="cytochrome P450"
                     /protein_id="WP_164253426.1"
                     /sec_met_domain="p450 (E-value: 8.1e-78, bitscore: 260.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSRYVPPIAPGKLPLIGHAVPLIKDRLAFIQSLRAHGPIVRIT
                     VGPKTMTVVNSTELIHKMLTSQSDEFTKGLLFEKLKLFGKDALPVAEGKPHLRRRRMMQ
                     PAFHREQIAGYVNTMRETVQPYIAGWDGGTPIDMKTEMQLMTQGVVMSALFSAAPRREP
                     AHTILNSVDTVFRTALQRALLPISALERLPTRRNRKARDAGSALRTAVAEIIAEHRANP
                     GAYDDVVSLLLTARDETGAALPDDEILSEVTGLLAAGSETTAVVLAWLFHELGRNPDLE
                     RRLHEEVDPVLAEGPITADRVPRLAFTRRLVSETLRLYSPAWLVTRQAISDVRLGEFSL
                     PAGTDVIWSAYALHRDPDIYPDPLRFDPDRWLPERPQPPKGAFIPFGSGKRMCMGDAFA
                     WTEATIITAMVASRWRLRPTPGTVRPVGAITTHPSSLHMVPELRHHAVTGRAR"
     gene            14099..15061
                     /locus_tag="SSPS47_RS28355"
                     /old_locus_tag="SSPS47_28770"
     CDS             14099..15061
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="SSPS47_RS28355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28770"
                     /product="terpene synthase family protein"
                     /protein_id="WP_164253427.1"
                     /sec_met_domain="T1TS (E-value: 3.2e-64, bitscore: 216.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDSTRTKAPALPMPDLRDSFPGPFPASAHADDIERHATEWLGTY
                     PLVASERKLGALANITGQGMARTFPAAGRTDLFLCADLFLWLTAFDDAHGEAAGARDPA
                     RLVRTTGEYVHLLAGHDEPPGSPGPFGAALGDLLARFAQRATPTQYLRLTAHLRDNLLG
                     ILWEAHHIDSPAHVTLSDYLAMRPHTVFVRTLMVTAEIALGHELTERDRSSESARELRT
                     AVADLAGWINDLASYAKETAHDGPTTLNLPSLLMREHGCDLEEAFRLASRMCEQQAAVA
                     SARIAELTVVEGPLSAHAGALKSIASSYVWHIDHSRYQI"
     misc_feature    15089..15102
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            15164..16165
                     /locus_tag="SSPS47_RS28360"
                     /old_locus_tag="SSPS47_28775"
     CDS             15164..16165
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852780.1"
                     /locus_tag="SSPS47_RS28360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28775"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_164253428.1"
                     /transl_table=11
                     /translation="MLRVDLRGRELARLRVADGADALWEAALSLHLLQNQHVPPAFAPW
                     RREVRSALERAGLASAVRELMLLCPSAEYFPDFLTPGRGELEIDVGVDRLLSTPRRRLV
                     ADLARLYARRRGPVPATVRRLSEGETEALRRLGTTLRRYYSLAVAPYLPAIRAQAAADR
                     SRRAEAALTGGAEGLVASYEEMPGWRCEEGILRTPYPVSRELRLYGQTLTLIPGFFCVG
                     TPLALVDDELPPVLVHPLSPAPGWLFRHRQGEVTPPVAQLIGTSRARLLELLDRPMTTT
                     GLAGALRMAPSTASRHASVLREAGLLTSHRHGNRMMHHRTQLGTALLDGPAP"
     misc_feature    complement(15166..15184)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.43"
                     /tool="antismash"
     gene            complement(16196..17584)
                     /locus_tag="SSPS47_RS28365"
                     /old_locus_tag="SSPS47_28780"
     CDS             complement(16196..17584)
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018545919.1"
                     /locus_tag="SSPS47_RS28365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28780"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_164253429.1"
                     /transl_table=11
                     /translation="MTGKTGWKRGRAALLGSVVAASLALAGQPATAAPYPGGAGTEAGS
                     GAMNTAFEKAATEFDVPRDLLVAVGYGETHLDGHGGRPSQANGYGVMHLVSQPKHKTLE
                     RAAKLTGESVADLKKDTAANIRGGAAVLRAVADEQGLDATDRDSLAEWYPVAAEYGAAA
                     NDRTARLYADTAYDLLNKGLRAQAAGNEQILVEARKVTPDRGKYASIASDFGVLSDDYG
                     PALWVPASTSNYQTGRTAAINQVVVHVTQGSYAGSISWFQNPSAQVSAHYVIRSSDGQV
                     TQMVRDANTAWHARSANASSIGIEHEGFVADPSWFTDSMYRSSAALTRHLTAKYGIPRT
                     RAGIVGHSEVPGNDHTDPGANWNWTYYMSLVNGGGGDPGPGTSFPTWGTGVSIRQAATT
                     TSAQVASLAGPTTVKVQCQKRGELVNYQGYSNDAWSYLPDYGGYISNIFIDVSDAWLPG
                     VPNC"
     misc_feature    17583..17597
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     gene            17996..18769
                     /locus_tag="SSPS47_RS28370"
                     /old_locus_tag="SSPS47_28785"
     CDS             17996..18769
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310765.1"
                     /locus_tag="SSPS47_RS28370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28785"
                     /product="M23 family metallopeptidase"
                     /protein_id="WP_164255104.1"
                     /transl_table=11
                     /translation="MLTVPAAAAEAAEAGTSDTAAEAAGPNFKAPYPCGQRWTYSHHSA
                     EVRRALDFVRADGGTTNGTPALASAAGTATRHSQPSGAGNYISIDHGGGWKTYYFHLGS
                     FSVASGQFVNQGQQIGTTGSSGNSSGPHLHYEQLLNGVGQNIVINGGGLPYPGSYNQHF
                     LTSDNGCGGGGGGTPFTTWGTDVSVRADARLNAAVVTRLAGPTNVHVVCQKQGDTVNAE
                     GYTNNWWSKLRDQGGFMSNIYIDHPAAQLPGVPLC"
     gene            complement(18906..19388)
                     /locus_tag="SSPS47_RS28375"
                     /old_locus_tag="SSPS47_28790"
     CDS             complement(18906..19388)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128524.1"
                     /locus_tag="SSPS47_RS28375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28790"
                     /product="DUF456 domain-containing protein"
                     /protein_id="WP_203557943.1"
                     /transl_table=11
                     /translation="MDVWQLVLVGLVMLLGVLGVLIPGVPGPAIVWAAVVWWALSDTSV
                     TAWALLIAATALLLLNQALRPLLPSRRTRETGTRRRTLLAGGLAGIVGFFVVPVVGTAP
                     AFVGGIYAVERVRLGSHRDGWASTRAVMRSAGVPVLVELFCCLLVAGTWLGVLVWG"
     gene            complement(19448..20449)
                     /locus_tag="SSPS47_RS28380"
                     /old_locus_tag="SSPS47_28795"
     CDS             complement(19448..20449)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049151.1"
                     /locus_tag="SSPS47_RS28380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28795"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_164253430.1"
                     /transl_table=11
                     /translation="MLGAIGLDERQESAYRALVALGAADAADLAHRLAMPEQDTERALR
                     RLEQHGLAAQSSARTGRWVAAPPAVALGALLTQQRHELERAELAAVLLAEEYRAESAGP
                     AVHDLVEVVTGASAVAHRFHQLQLGATEEIRALVTGRPVVVTGVDNESEERVVTRGVRY
                     RVVIEREVLSLPDGITELSAALGRDEQVRVVDRVPTKLVIADRALAMVPLTGGDAEPAA
                     LVVHSSGLLESLSGLFEAVWRDALPLRLVPGGDGAAVVEDAAEGPGETDLEVLSLLLAG
                     MTDASVAKQLDLGLRTVQRRVKALMELAGVTTRLQLGWHAYEKGWVARDLRE"
     misc_feature    complement(20422..20437)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    20894..20903
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.82"
                     /tool="antismash"
     gene            20930..22567
                     /locus_tag="SSPS47_RS28385"
                     /old_locus_tag="SSPS47_28800"
     CDS             20930..22567
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523747.1"
                     /locus_tag="SSPS47_RS28385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28800"
                     /product="protein phosphatase 2C domain-containing protein"
                     /protein_id="WP_164253431.1"
                     /transl_table=11
                     /translation="MSQQGDRPATTDDWWGRLYDESAPDTGPAEAPDDTIEDRFDSAAD
                     TLGAEGAADATTRAGYGRAVDAIGVDDEEDAGDEDEDMDVGAAAGGGPVSRPMAWWEAR
                     GAYPVIQAPAPGPASPPTTVDRPGAAPAPPPAQAPAPGPVAPAPLTPRPRAPWEPPPAA
                     FDPGPAGPLPDAADPAPPPVTTPVRTPAPDPRAAAPEPPVPPRPAPKPAPAPAAPVTHV
                     GDGPPTYDDEPTALPAAEAEELGQLVADTVLDGARYGTYTLRAASMRGDSARYRGEPRR
                     DALLTARFGAGASALVLVAVATGARATEGAHLSAADACRWIGGAVGRSCDRLAEDIRAG
                     RRGDLKSGLHRLTDRTYGKLRARAAELGREPEDYTASLRCLLLSADPECRTRVFFGVGG
                     GGLFRLRDGAWQDLEPLLPEPADIRGEPVLGFGSPRSDAEEQTPEGDRLTMDLEITKPP
                     GPVVEDPVPPPPEPFRFRASVARPGDTLLLTSVGLAEPLRGEPALGDELAARWASAEPP
                     GLAEYLSDVRLRVKGYADDRTAVAVWEA"
     gene            22665..24413
                     /locus_tag="SSPS47_RS28390"
                     /old_locus_tag="SSPS47_28805"
     CDS             22665..24413
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956787.1"
                     /locus_tag="SSPS47_RS28390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_28805"
                     /product="pyruvate dehydrogenase"
                     /protein_id="WP_147875015.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-41, bitscore:
                     140.9, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.4e-38, bitscore:
                     129.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARQNVAEQFVDILARAGVRRLYGVVGDSLNPVVDAIRRNAAIDW
                     VQVRHEEAAAFAAGAEAQITGKLAACAGSCGPGNLHLINGLYDAHRSMAPVLALASHIP
                     TAEIGLGYFQETHPERLFEECSHYNEMISSPEQMPRLVQTAIQHAVGRGGVSVVTLPGD
                     IASRPAPTKAIEHALVTSRPTVRPGDLEIDKLVDMIDDADRVTLFCGSGTAGAHAEVME
                     FAERIKSPIGHALRGKEWIQYDNRFDVGMSGLLGYGAAYEATHECDLLILLGTDFPYNA
                     FLPDGTDVKIVQVDVRPERLGRRSQLDLAVWGDVRETLRCLTPRVRMKSDRRFLDKMLK
                     KHADALEGVVKAYTRKVDKHVPIHPEYVASVLDEVADDDAVFTVDTGMCNVWAARYLSP
                     NGRRRVIGSFSHGSMANAMVQAVGAQFVDRERQVVSMSGDGGFTMLMGDFLTLVQYELP
                     VKIVLFNNSALGMVELEMLVAGLPSYGTTNRNPDFAAVARAAGAFGVRVEKPKQLAGAL
                     KDAFKHKGPALVDVVTDPNALSMPPKISADMVQGFALSAGKIVLDGGVGRMVQMARSNL
                     RNLPRP"
ORIGIN
        1 cgcgcagcat cggcagcgcg ttcgtcaacg gggtgtagga ggtgccgggc agggtctcct
       61 ggaggccgat gaggtgcagg gcccaggtgt tgtcgctgat gccgtagcgg ccgtcggcga
      121 cgagcgaggg cgcggtcacg ccgtacgggt cgacgccgtc ggtccagtcg cgcagggtca
      181 gcgcgggcgc gccgaccgcc ttctccgcgt cgggcgcctc cagtttgggc acgacgagga
      241 cgggaccggc gtcgggggtg agcaccagca gggtcagccg ctcggtgtcg gcgggcggct
      301 ggtagccggt gagccagacc atgtcgggac cgggcgccac cagcacgccg gccagcccgg
      361 cggcggtggc gtcccgcacg gcgcggtcca tgcgcgcgcg gtagtcgtct gcggtgaagg
      421 gggccggggc cgcgggggcc ccggcggtcg ggtgcgcgga agtcgcgtcg ctgccagtca
      481 tgcgtccatc ctgccgccgt cgcgggccgt ttcggcaccc ggcggcggca gggctccggc
      541 gacgcggcag gacggcccgt gggagggcag gaccccctta cggcttcggc tgggtgaagc
      601 ggatgttgtt gccgaagggg tcgcgcagtc cgcagtcgat gccgtacggg cgctcggtgg
      661 gctcgtccgt gaactcgacg ccacgggccc gcagcgtctc gtaggtcccc cggcagtcat
      721 ccgtgctgaa gatgagcgtg ccgcccgtcg cgcccttggt cagcagttcg cggacctccc
      781 gcgccgtctc ctcggacagc gccggagggc cgggcttctc cagcaggatc tgccggtccg
      841 ggtggccggg gacgttgacg gtcagccagc gcatgaagcc caggtcggcg tcggtgttga
      901 cctccaggcc gagtgtgccg acgtagaagt cgagcgccgc gtcctggtcc aggacgtaaa
      961 tctgtgagtg tgtgatcgcg gtgaacatgc gtttcacgtt acggggcacg ccgggcgaaa
     1021 acttgtccag aactgctcgg tcggcgtgtg gccaccgcac cggggagcgg ggacgggggc
     1081 ggggaggggc cggcggtcag gtgctcggtc gcgtccacgc cttggtgaag cacgtcggta
     1141 cggcgccggc cgcgcgcggc gtctccttgc ggtacgtcct cggcggccgg cccacgatct
     1201 cgtggaacgt gcggctgaag gtcgccggac tgccgaagcc gacctcgtaa cagatgtccg
     1261 tcacgctgcg gtcggtctcc cgcagcagga acatcgcccg ctcgacccgg cgccgctgca
     1321 gataccggtg cggcgtctcg ccgaacgtgg cccggaaggt ccgggtgaag tgcgcctgcg
     1381 acacgtgcgc gatcctggcc agggccggga cgtcgagcgg ccgcgcgtag tcacggtcca
     1441 tcgcgtcccg cacccggagc atgcggcggt tgctctcttc cacgtcacgg cccacgcacc
     1501 catcagacca cgggacgccc accggccccg gagcggtgtg ccggcgtctt tgggggcgga
     1561 cgcccggctg gccgccgcga cggggcggtc ctagcgtgga gagccggggt cgaacgcggt
     1621 gcgacagtga gaaggagtac ggaggcggac tgacatcgca tgactgacat cgccgcggcc
     1681 gactggtggg gcctgctgcc ggccggagtc cgcgaacagg ttgacgggta cgtcctccag
     1741 gacgaccgca tgcgggcggt acgcgccgtc ttcgaggccg gccgggcccg tgggatgggg
     1801 ctcgtggagg cccaactcgt cgtgcacgag cggtatctcg tccacggcga ccggatcgcc
     1861 cgtactcccg agagcccact cgacctggag tcgccggcct cttccccgcc cgcctccgcg
     1921 tgctcgtcgt gcgccgccgg cggcttctcg gccgcgtcgg ggtcgatgct cgcgccgact
     1981 ccgtacgcgg tgccgaacgt cgcgacgatc gcggcggcga aggcggtgat cctgagtccc
     2041 gtgttcatcg gggtctcctt cgtgaggggc cacggcggcc gacatcctct acataccctc
     2101 caggggtatg tagtcaagtc ggggtcctgt ctgcgtcgaa tacctggggc aggtatgcgg
     2161 gcccggtccg cacgccggtc cggcggcgcc gcgacacgcg tcgtgccggc accgcgacaa
     2221 ttggctggcg cgcccggcgg gggagcggct agattccctc ctgttcccga cggaccgatc
     2281 gggtcctgtc agccgtgtgt gatccaggag gtgtgtaccg atgactgtct ctgcgctggg
     2341 ccctgcccgc gatcagctga tcgttcatgt cacctccgtg gtctccggct gaccttcctt
     2401 ttctccgcgc cccgtcggcg cgcgtgccgg gaccgccctt gtgaagggtt tcccgttgtc
     2461 tctctccacc gcctctcctg aggcatcctc cgcttcgcat ccgctcgccc cgtacggctg
     2521 ggacgagggc tgggagacgg agttcacccc gtacgccgcg cagggcctgc tgccgggccg
     2581 cgtcgtccgg gtcgaccggg ggctgtgcga tgtcgtcacg cccggcggca cggtacgggc
     2641 cgacaccgag ttcgtcgtgc cgcgcgaccc gctgaaggtc gtgtgcaccg gggactgggt
     2701 cgccgtcgac cccggcggtg atccgcggta cgtgcggacg ctgctgccgc gccgcaccgc
     2761 tttcgtccgc tccacctcgt ccaagcgctc cgaggggcag atcctcgcgg ccaacgtcga
     2821 ccacgcgatc atcgccgtcc cgctcgcggt cgaactcgac ctcgggcgca tcgagcggtt
     2881 cctcgccctg gcctgggaga gcggcgcgca gccgctcgtg gtgctcacca agtccgacct
     2941 cgtaccggac ccgaccggac tgtcgtacct cgtcgacgac gtcgagacca cggcgccggg
     3001 cgtgcaggtc ctcccggtca gcgcggcgac gggggagggc gtcgacgtgc tgaccgccgt
     3061 cgtctgcggg agcacgagcg tgctgctcgg cgtctcgggc gccggcaagt cgaccctcgc
     3121 caacgccctg ctcggcgagg acgtcatgga ggtccaagcc acccgtgacg tggacggcaa
     3181 gggccggcac accacgacca cccgcaatct cctcgtgctg ccgggcggcg gcgtactcat
     3241 cgacactccc gggctccggg gcgtcgggct gtgggacgcc gggcagggcg tggggcaggt
     3301 cttcgccgag atcgaggaac tggccgagga gtgcaggttc cacgactgcg cccacggcag
     3361 ggagccgggc tgcgccgtgc tcgccgcgct ggaggacggc tcgctgtccg agcggcggct
     3421 ggagagctac cgcaagctgc tgcgggagaa ccagcgcatc gtcgccaaga ccgacgcccg
     3481 gctgcgtgcc gagatccgcc gggactggcg gctcaagggc gcggagggcc gcgcggcgat
     3541 ggaggccaag cgggggcgta tccggtagac gcggccggca ggcgcgtccg cgagggccgg
     3601 gcttcgagcg ggaggcccgg ccctccacct ccatgtccga atcccgcgag tgccgtactc
     3661 ggggggcggc gcacactgga ggctgtgatg gacgaagaga ccaggtacga ggcggtggcc
     3721 agccgcgacg cgcggttcga cggcgcgttc ttcttcgccg tcgagaccac cggcatctac
     3781 tgccggccga gttgtccggc ggtcaccccg aagcgcgaga acgtccgctt ctaccccacc
     3841 gccgccgcgg cccagggcaa cggcttccgc gcctgccgcc ggtgccggcc cgacgccgtg
     3901 cccggatcgg cggagtggaa cgtacgggcc gacgtcgtcg gccgcgccat gcgcatgatc
     3961 ggcgacggag tcgtggaccg cgagggcgtc cccggcctcg ccgggcggct cggctacagc
     4021 gccaggcagg tccagcgcca gctcaccgcc gaactcggcg ccggccccgt cgccctcgcc
     4081 cgcgcgcagc gcgcgcacac cgcgcggaca ctgctccaga ccaccgtcct gccggtcacc
     4141 gagatcgcct tcgccgccgg gttcgcgagc gtgcggcagt tcaacgacac gatccggcgg
     4201 atctacgccc gcaccccgag cggcctgcgc gccgagtccg gcaccggagg cgcaccggcg
     4261 acccccgccg cgcccgcact cgccggcatc ccgctgcggc tcgcgtaccg gggcgcctac
     4321 gcggcgcgcg ccatgttcga ccagctcgcc gacgaggccc tgacctccgt cgaggaggtg
     4381 atcggccgac cgggcgcccg tacctaccgg cgtacgctgc gcctgccgca cggccccgga
     4441 gtcgtctcgg tggacgaagc gccgccgtcc accggcgccc cgcgccccgg ctggctggag
     4501 gcccggatcc acctcacgga cctgcgtgac ctcaccaccg ccgtacaacg gctgcggcgc
     4561 ctgctcgacc ttgacgccga tccgtacgcc gtggacgaac gcctcggtgc cgacccgctc
     4621 ctcgcgcccc tcgtcgcggc ccgccccggg cttcgggcgc cgggcaccgc cgacccggcg
     4681 gagtacgcgc tccgcgtgca cctgggaggg gccgaggcgc ggcggctcgt cgcggcgttc
     4741 ggggacccgg tcgagcgccc gtgcggcacc ctcacccgcc tcttccccgc accggcggcc
     4801 ctggtggacg acccggtggc cggtccgctc gccaccgccc tcgccgacgg caccgtacgg
     4861 ctcgacagcg gggcgagccg cgaggaggcc gaacgggcgc tgctcaccgt gcccggcgtg
     4921 agcgcccgga cggcggcgct gatccggatg cgcggcctgg gtgatcccga cgtggcaccg
     4981 gacggcgggt ccggtgacgc ggcgtggcgg ccgtggcgtt cgtacgcggt acggcacctg
     5041 ctcctggggc tgcccgcccc cgcgatcagc cggtctcctc cagcccccaa ctgtgaatct
     5101 tccgtggatg gatccggatc agttcttcac tgaagtgcgg acccaactcg tgcggaccgg
     5161 tgaggagttc ggcctcgccc cggatgtcca caccccgcac cttccacggc ttgaggctga
     5221 cgatgtcgtc caccaccagt gccacccgcg ggttcgaccg caggttccgc cacttcttgg
     5281 tggtgcccag cgcgtacccg ccgaccagga tcgtgccgtc cgcctgcggg aagaaaccca
     5341 ccgggttggc ctgcggctga cccttcgggt cgacggtggc cagccggccc agccgctggg
     5401 aggagaggta cgagcgctcg gcctcgctga attcggtcat gactccagcc tcacacgccc
     5461 tgggtgctcc cgccgctccc ggtcttccgc acgcgctcgc gtctcaagcg gagggccggg
     5521 cgacggagtc cggccggaga gcggaatgga atcggccggt ggtgcagcgg ttgctcccca
     5581 cctggcccta tttcttcccc catgatcatc acggcctcct gattcgcgct gtgggcagta
     5641 ggccaactcc cctaaactgg ccaagctttg gcatgatcct tcacctggat gcggcagcac
     5701 ttgatgtgcg gaagtccacc ggtgtacccg cccgtgcccc ctcgaacccc taggaccctt
     5761 tttccgtgac ctctccctca gaacccgccc ttgcgctcgg cgccgtgacc gtggtcatgg
     5821 ctgtcgtcgc actgctgctg gcgctctccc gtcgcaaaca gacgcgacgg tgcagagaaa
     5881 tggacgcggc gctgaagagc gccgaatccc gcacgcggga agccgaaacc cgcacgcgct
     5941 tcgccgaatc ccatacgcgg gacgccgagg cccgtgagga gcggttccgc gccgaggtga
     6001 cccacctcgt ctccgcccgg cttccggccg tcccgctcca tctgatcagc tctcaccacc
     6061 ccgtacccgg gctgctcaac gcaggggagg cgggacccga ggacgcggaa ctcctcgact
     6121 ccgtactcac ccgcgtctcg gagatggtcc tgaaggagcg tcgtcgcgtg gacgccgccg
     6181 ccagggccgc cctgcgcggc gcgagccagg actcgcaggc cctgtcgtac cggctgcagt
     6241 cggaactcga cgccctgcag agggagttca ccgggtcacg gcatctgacg cacaggatgc
     6301 tcgccgccga ccacctcaac gagcagaacc tgcgcctcat ccagcgcacc gccatcgtgt
     6361 gcggcgcgtg gccggggcac gtccgcaagg acacctacgt cgccgagatc gtcacgggcg
     6421 cctcttcccg gctccgcggc ttcgaccgga tcaagatcaa ctcgcggata gcctccaacg
     6481 tcgggatcgt cggccgtgcc gccgagcccg tcgccgtggc ctgcgccgag ctgatggcca
     6541 atgccctgga gcactcccgt gacgacctcg cggtggacgt cggcctgatc cagagcggaa
     6601 acggcaacgt ctgcatcacg gttgacgacg cgggcaaggg gatgaccgcg gaggcggcca
     6661 cccgcggtgc gcgcctggtg tcggccgaca cgcacgatgt catgctgacc gagctcggcg
     6721 acccgccgtc ccagggtttc gccgccatcg gccgtctcgt cgccgactac ggcttccatg
     6781 tctccatcga ccattcgtct ccctatggcg gggtgcgcgc tgtggtgacc attcccccga
     6841 acctgctcgc ctcgatcgac gaggaagccg agcccccttc tgccatggct ccccaggcgg
     6901 ccgtcgcacc gaaggcggag aggcggccca cttccgtccc cgagaccccg gtggacgacg
     6961 agaagccgcg aactcccgta ccggacagtg cggacggtct gccgcagcgt cgccgccgtg
     7021 gccccgcggc ccccggcgca ggactagccg ctcccacgta ccgcgccccg gatccggagc
     7081 ggtccctcag agcctggagt gaattccagg acggccttga aagcggccga accggtactg
     7141 atttggagga aacgcagtga ccatgcccca cggcgaaaac gagacctggt acctggcccc
     7201 catcaccgag atcccaggtg tccaccacgc cttgctgatg accctcgacg ggatggtcca
     7261 ggccaggtcc gagaacctct cggccgacga cgcggacggc gtggccgcga tgacctccgc
     7321 actgcacgcc gcctcccgtg ccgccgtgat cccggcgctg ggggccgcgg cggacacccc
     7381 catcgagacc gtcacggtga aggtggccga gggcacctac atggtcatgc cggccggtgc
     7441 caacacgctg atcgccgccg cgggcgacga ttcgatgcac atgggtgtgg tcgtccacat
     7501 gatggcgcgt caggcgaaga agctgggtga gcagcacatg tccgtctcgg cgcgcaccca
     7561 tgacggcgcg tcatgagccg cggtcagcat caacggcggc tgcttccggc gtatctggcg
     7621 accggaggcg gcggcggtgc cccgttaccc accaccctcg acacgctgac ggcgctgcgg
     7681 gccagtggcc atccgttctc ctcgtaccac acgtcggtgc accgccgtgt ggtcgagctg
     7741 gtgacggacg gttccctcac cgccgtcgag atagccgcgt atctcgcgct gccggccagt
     7801 gtcggtctga tgctcgccga acagctcgtc agtgacggct tgttaaacgc cagcgtgccg
     7861 ataccggaag ctctcgcccc ctcgcgcgcc ggacggccgt cgatgcaact catggaagag
     7921 gtgctgagtg gactccaatc gctccgtgtc gcctaacccg cgtcccgtgt acctccccga
     7981 gggggagcac cagagggtca agatccttgt cgcgggtccc ctcggcgtcg gcaagacgac
     8041 cgcgatcaag acgctttcac agattcccac gctgcacacc gacgaagtca tgacggacgc
     8101 ggcggccgac gccgacgacg tcagcctcgt cggtctgcgg gacaagaaga ccaccacggt
     8161 ggccatcgac ttcggtcgaa tgaccctgcc gggcgaccgg atcgtcctgt acctgtacgg
     8221 aactccgggg cagcgcaggt tccttccgct gtgggagggc atcgccttcg gcgccctcgg
     8281 cgcgctcgtc ctggtggaca cccggcgtct cgacgagtcc ttcgaagtga tggatcttat
     8341 cgaggagcgc ggtttgccgt acgccgtggc agtcaatacc ttccctgact cacccgatta
     8401 cgatctggag atcgtccgca agaagctgga cctcgccccg gacaccccgc tcgtcacctg
     8461 tgatgcccgc gagatgaaca gcagtctcag cgcactcatc gcactgaccg cccattccat
     8521 atcctcggcc ggagtcggag cctcgtgagt atcacaccac tggacgtcac cgctgtgccc
     8581 ctgcacgggc cggaacacgc ggccgatccc cagcgcagct atgaactgct gcgccgccag
     8641 gggccggtcg gcgtcgccga gatctccccc ggtgtcctcg tccacctcgt caccgactac
     8701 caggcggcgc tcgggctcct gcaggacacg gagacctggt ccaaggacac ccgtaagtgg
     8761 ctgccgcagg ttccggagag cagcccgatc cggccgatgg tggagtggcg gcccagtctc
     8821 ttcttcgccg acggtgagga gcacgcgcac ctgcgcaagg tgatcacgga cagtttcgcc
     8881 ctcctggacc ccaacgacgt acgggttctg acgttccgtt tcgccgaccg gctcctgcag
     8941 gacttcgcgg acgccgggac cgtcgacctc gtcagccagt acgcgcagca gttgccgttg
     9001 atggtgttca acgccctgtt cggcatggag gacgaacacg gtccccggct cgtgggggcg
     9061 ctcgcggcga tgatggacac cgaccccgaa cgcaaggcgt ccggcgccca gttgttcggc
     9121 ggctatctgc agaccctcta tcaggccaag gccgagaagc gcggccacga cctgacctcc
     9181 tggttcatcg accaccccaa cgggctgaac caggaagagg tgatgaacca gatcatcatc
     9241 atcttcggtg cggggaacga gccgacggcc aacctcatcg cgaacacctg cgtccggatg
     9301 ctgagcgacg accggtactt cggcacgctc accaccggaa gcctgcccgt ccagcacgcc
     9361 atcgacgagg cgctgtggca cgactcgccg ctcgccaact acagcttcca cttccccaag
     9421 gaggacgtca ccttccacgg cacgcgcatc cccgcccact ccccggtcat ggtctcgtac
     9481 gccgccgcca acacctgccc ccactcgggg gttccggccg acggctaccg ctcgggaacc
     9541 aaggcacacc tggcgttcgc cgccgggccg cacgcctgcc cggcacgtga tctcgccctg
     9601 ctgatcgcga cggccgcgat cgaacgactc gccagctacc tgccggacat cgaactggcc
     9661 gtagcgcccg atcagttgac ataccgcgac gggcccgtcc accggacgct cacgtcgctc
     9721 cccgcccggt tcactccgct gactcccgac gccaagggca tcaccccttg gagccgcagc
     9781 tccgccggcc cgcggacagt caccggggcg tcctcgacag caggcgaccg tatgtcggtg
     9841 acaacttcct gacctgccct cccatgccgt gtcgcggtgg tgccgtcggc caaggacccg
     9901 caccaccgtg acacccgcgg gaaagccggt gtcctggccg cgtcctctgc ccgaacggaa
     9961 ccaccatgac ggttctcgac cgaaagggga tcaaccaccg atggcaacca catgtcccgc
    10021 cgccagtcca ccggacctga tgtccgtacg gcaccaggtg agcgcggccc tgaccacatt
    10081 cctcgacgcc aaggaggagg cggcgccggg gaccgaactg ctctatctga cctccacctt
    10141 gcgcgcgttc ctcaccggcg ggaaacggct gcgatccgtg ctgtgcgtct acgggtggca
    10201 cgccgccggc ggggacggag agatgacggc cgccatccgc gcggccgcga gcctcgaact
    10261 cttccaggtc ttcgccctcg tgcacgacga cgtgatggat gacagcgatg tccgacgcgg
    10321 ccggccctcc gcgcaccgcg cgctggccgc cgcgtacacc gacaacggcg gtccccacgg
    10381 gcgtgccgcc gcgcacgggc tgggcgccgc cgtcctcctc ggagacctgg cactcgtgtg
    10441 gtccgacgaa ttcctccata cggcgggcct cgacccgagc aggctcgccc aagtgctgcc
    10501 gctggtggcc gagatgcgca gcgaagtgat gtacggccag ctcctggacc tgcagaccac
    10561 cggccggctg accggcgatg tcgaaacggc gctgcacgtc atccggtaca agaccgccaa
    10621 gtacaccgtg gaacgccctc ttcacatagg agcggcggtg gccggagccc cgccggccgt
    10681 gctcgacgcc tgcaccgcgt tcggcgtccc actgggagaa gcgtttcagc tgcgggacga
    10741 cctgctcgga gtgttcggcg atcccgcgga gaccggcaag ccggtactgg acgacctgcg
    10801 cgaggggaag gccaccgtac tgatggccct cgccgtccag cgagcctccg ccaccgagcg
    10861 cgggaccctg cgcggcctcg tcggccggag cgacctcgac gaggaccagg ccgccgagat
    10921 acggaccatc ctcgactcca ccggcgcccg gcagagcgtg gaagagaaga tcaccgcccg
    10981 ccgcgacgag gccctcgccg cactggacga ggcgcccttc ccggaagaga ccaccggccg
    11041 gttgcgcgag atcgccctgg ccgccacgga gcggcggaca tgaccgcccg cccgtccacc
    11101 gtcaccgcaa ccgtgaggtc gaacgaaccc gtgaacgaca cggtcgcgaa cgcgacctac
    11161 cccgaacagg ccgcccgact ggtggccggc atcgaccagg acccgtgggg cagcgtccgc
    11221 ccctccctgt acgagaccgc gcgggtcgtc tcggcggccc cctggctgtc cggcgaacag
    11281 cgccggatcg cgtatctgct caacgcgcag gcacccgatg ggagttgggg tgaagggccg
    11341 gagcgctacc ggctgctgcc gaccctcagc gccgtggaag ccgcactggc gctcctggga
    11401 cggggaggca tgtccgagga gacgacccgg cgcctcacca ccgcggtcga cagcggtctc
    11461 gccgcgctgc gcgcgctgcc ctcggcagga ccctggcccg acaccgccgc ggccgagatc
    11521 ctcgtccccg gcctcgtcgc gaagatccac gagcggctca cccacgtcgg agacgaccgg
    11581 acaccggtcg tcggcgactg gcgtccgggg ccggcgcccg cgcttcccgg aggctacgac
    11641 cagtccgtgc ccgggtacct ggccaggcgg tacgcctcgg cgggcagcct ccccgtcaag
    11701 ctgcaccaca ccttcgaagg cgtggccggg tacataccag gggcgctcat acccgacggg
    11761 ccggacctgc tgggcagttc accggccgcc accgccgccc gggccgcggt ctcgcacgag
    11821 ccctccgccg ggaccgtcgc ggccctcgaa gccgtggcgg aacgctactc gggcctcttc
    11881 cccgaggcgg ccccgatcct tgtcttcgag cgcctgtggg tcgccgccgc gctggccggt
    11941 gtcgatctgc cccccaccag tgtgcccacc gtccgcgcct gggccaccga cctctacgac
    12001 ccccggggag tgcgcggcgc acccggactc atgacggacg ccgacgacac cgccatggcc
    12061 gtgctggtgt cctcactggt cggcctggac cacacccccg agccgctcga cctgttccac
    12121 aacggcagtc actacgactg ctacataggc gaggacaccg gatcggtcac cgccaacgcc
    12181 cacgcgctcc acgcgctcgg cagctatctg cgccaccacc ccgaggcaca gcacacctac
    12241 ggtccccggg cggacaagct gagcgactgg ctcgtcgggc agcagcggcc cgaaggaccg
    12301 tggcccgaca aatggcacgc ctcgccctac tacgccaccg cgcggtgtgt ggccgcgctc
    12361 tcgcgccacg gcggagaccg ggcggccacc gccgtcggga cagccgtggc ctggaccctc
    12421 gacacccagc gcgacgacgg ctcctggggg atctggggcg gcaccacgga ggagaccgcg
    12481 tacgccgcgc ggatcctgct ggcgacagcc gatccgcggc cccggcacct gcgcgccctg
    12541 gacctcgccg agacgtatct gaacgaaggg gccggctccg gcgagcaccc cgctctgtgg
    12601 cacgacaaga ccctttacgc gcccggcgcc atgatcgagg ccgaagtcct cgccgtgcgg
    12661 gaactgttgc gcacacggca cggcactgcc tggccgggcg ccggacgacc gcatccaacg
    12721 acgcgggaag gtaggacaga cacgtgacga ccagcagata cgttccgccg atcgcgccgg
    12781 ggaagctgcc gctcatcgga cacgccgtac ccctgatcaa ggaccgcctc gccttcatcc
    12841 agagtctgcg cgcgcacggc cccatcgtcc gcatcaccgt cggcccgaag acgatgacgg
    12901 tggtcaactc gaccgagctg atccacaaga tgctcaccag ccagtccgac gagttcacca
    12961 agggactgct cttcgagaag ctcaaactct tcggcaagga cgccctgccc gtcgccgagg
    13021 gcaagcccca tctgcgccgc cgccgcatga tgcagccggc cttccaccgc gagcagatcg
    13081 ccggttacgt caacaccatg cgggagaccg tgcagccgta catcgcgggc tgggacggcg
    13141 gaaccccgat cgacatgaag accgagatgc agctcatgac acagggcgtc gtcatgtccg
    13201 ccctgttctc cgcggcgccc cggcgcgaac ccgcccacac gatcctcaac agcgtcgaca
    13261 cggtcttcag gaccgcgctc cagcgcgccc tgttgcccat ctccgccctc gaacggctgc
    13321 ccacccggcg caaccggaag gcgcgggacg ccggcagcgc gctgcgtacc gcggtcgccg
    13381 agatcatcgc ggaacaccgc gccaaccccg gggcgtacga cgacgtcgtc tcgctgcttt
    13441 tgaccgcgag ggacgagacc ggcgcggcgc tgcccgacga cgagatcctc tcggaggtca
    13501 ccggactgct cgccgcgggc tccgagacca ccgcggtcgt cctcgcctgg ctcttccacg
    13561 agctgggccg caacccggac ctggaacgcc ggctccacga ggaggtcgac cccgtcctcg
    13621 ccgaaggccc gatcaccgcc gaccgcgtcc cccggctcgc cttcacccgc aggctcgtca
    13681 gcgagaccct gcggctgtac agccccgcgt ggctcgtgac ccggcaggcc atctcggacg
    13741 tgcgactggg cgagttcagc ctgccggccg gcacggacgt gatctggagc gcctacgcgc
    13801 tgcaccggga ccccgacatc taccccgacc cgctgcgctt cgaccccgac cgctggctcc
    13861 cggagcgtcc ccagccgccg aagggcgcct tcattccctt cggttccggc aaacgcatgt
    13921 gcatggggga cgcgttcgcc tggacggagg cgaccatcat cacggcgatg gtcgcctccc
    13981 gctggcggct ccggccgaca ccgggcaccg tacgtccggt cggcgcgatc accacgcacc
    14041 cgtcgtcgct tcacatggtc cccgaactca ggcaccacgc cgtcacgggg agggcccggt
    14101 gaacgactcg acgcgcacga aggcgcccgc ccttccgatg cccgacctgc gggactcctt
    14161 ccccggtccc ttcccggcga gcgcgcacgc cgacgacatc gagcgccacg ccaccgagtg
    14221 gctcgggacg tacccgctcg tcgcctcgga gcgcaaactg ggcgccctgg ccaacatcac
    14281 cggccagggg atggcccgca ccttcccggc cgccgggcgg accgacctct ttctctgcgc
    14341 cgacctcttc ctgtggctca ccgcgttcga cgacgcgcac ggcgaagcag cgggagcccg
    14401 cgatccggcg cgtctggtcc gcacgaccgg tgagtacgtc cacctcctcg ccggccacga
    14461 cgaaccgccg ggcagtccgg gtcccttcgg cgccgcgctg ggcgacctgc tggcccggtt
    14521 cgcgcaacgg gccactccca cgcagtactt gcggctcacc gcacatctgc gggacaacct
    14581 cctgggcatc ctctgggagg cgcaccacat cgacagcccg gcccacgtca ccctgtccga
    14641 ctacctggcg atgcgtccgc acaccgtctt cgtgcggacc ctcatggtca cggcggagat
    14701 cgcactcggc cacgaactga ccgaacggga ccggtcctcg gagtcggccc gggaactccg
    14761 gacggctgtc gcggacctcg ccggctggat caacgacctc gcctcgtacg cgaaggagac
    14821 cgcccacgac ggaccgacca ccctcaacct gccgtcgctg ctgatgcgag agcacgggtg
    14881 cgacctcgaa gaggcgttcc ggctggcctc ccgcatgtgc gaacagcagg ccgccgtcgc
    14941 gtccgcccgg atcgccgaac tgaccgtcgt cgaaggcccg ttgtccgcgc acgcaggagc
    15001 cctcaagtcc atcgcgtcct cctacgtctg gcacatcgac cactcccggt accagatcta
    15061 ggtcctgtcc ggccggaccg ggccgtgctc gacagcgatc aaggcgcgac ccggtcccgc
    15121 tacactccgc cctgaacgca caggctttcc gggggagccc aacatgctgc gagtcgatct
    15181 ccgtggacgg gagctggccc ggctgcgcgt ggcggacgga gccgacgctc tgtgggaggc
    15241 cgcgctcagc ctccacctgc tccagaacca gcacgtcccg ccggccttcg ctccctggcg
    15301 gcgcgaggtc cgctcggccc tggaacgcgc cggactggcc tccgctgtaa gggaattgat
    15361 gctgctgtgc ccgtcggccg agtacttccc cgacttcctg acgcccggcc gcggcgagct
    15421 ggaaatcgat gtcggtgtgg accggctgct gtcgactccc cgccgccgcc tggtcgccga
    15481 tctcgcacga ctctacgcgc gcagacgtgg accggtcccg gccaccgtac ggcggctgtc
    15541 cgagggtgaa acggaggcgc tgcgccggct cgggactacg ctgcggcggt actactcgct
    15601 cgccgtggcg ccgtacctgc ccgccatccg cgcgcaggcc gcggccgacc ggtcccgccg
    15661 cgcggaggcg gcgctgaccg ggggagcgga gggactggtg gccagctacg aggagatgcc
    15721 cggctggcgc tgcgaggagg gcatcctgcg cacgccgtat ccggtcagcc gcgaactccg
    15781 gctgtacggg cagacgttga cgctgattcc gggtttcttc tgcgtcggta caccgctggc
    15841 tctcgtcgac gacgagcttc ccccggtgct ggtccacccg ctgtcccccg cgcccggctg
    15901 gctgttccgc catcggcaag gtgaggtgac gccacccgtc gcccagctga tcggcacctc
    15961 gcgcgcccgg ctgctcgaac tgctcgaccg gccgatgacg acgacgggtc tggcgggggc
    16021 gctgcggatg gccccctcga cggcgagccg gcatgcctcc gtactccgcg aggcgggcct
    16081 gctcacctcg caccggcacg gcaaccggat gatgcaccac cgcacccagc tgggcaccgc
    16141 cctgctggac ggccccgccc cctgaggcgg tggtgcatca actacggctg ggagatcagc
    16201 agttgggcac gcccggcagc cacgcgtccg agacgtcgat gaagatgttc gagatgtagc
    16261 cgccgtagtc cggcagatac gaccaggcgt cgttgctgta cccctggtag ttgaccagct
    16321 cgccacgctt ctggcactgg accttgaccg ttgtcggtcc cgccagactg gccacctgcg
    16381 ccgaggtggt cgtcgccgcc tgacggatgc tcacgccggt gccccacgtc gggaacgagg
    16441 tgccggggcc cgggtcaccg ccgccgccgt tgaccagcga catgtagtag gtccagttcc
    16501 agttggcgcc ggggtcggtg tggtcgttgc ccggtacctc gctgtggccg acgatgcccg
    16561 cgcgggtgcg cggaatgccg tacttcgcgg tgaggtgacg ggtcagcgcg gccgacgagc
    16621 ggtacatcga gtcggtgaac caggacgggt cggcgacgaa gccctcgtgc tcgatgccga
    16681 tggagctggc gttcgcggaa cgcgcgtgcc aggccgtgtt ggcgtcccgg accatctggg
    16741 tgacctggcc gtccgaggag cggatcacat agtgcgcgct gacctgcgcg gacgggttct
    16801 ggaaccagct gatggagccg gcgtacgacc cctgggtgac atggacgacg acctggttga
    16861 tcgccgccgt acggccggtc tggtagttcg acgtgctcgc cgggacccag agcgcgggcc
    16921 cgtagtcgtc gctcagcacg ccgaagtccg aggcgatgct cgcgtacttg ccgcggtcgg
    16981 gcgtcacctt gcgcgcctcg acgaggatct gctcgttgcc ggcggcctgg gcgcgcaggc
    17041 ccttgttcag caggtcgtac gcggtgtccg cgtacagccg cgccgtccgg tcgttcgccg
    17101 ccgcgccgta ctcggcggcg acggggtacc actcggcgag cgagtcgcgg tcggtggcgt
    17161 ccagaccctg ttcgtcggcg acggcgcgca ggacggcggc gccaccgcgg atgttggccg
    17221 ccgtgtcctt cttgaggtcc gccacggact caccggtgag cttcgcggcc cgctccagcg
    17281 tcttgtgctt cggctggctg accaggtgca tcacaccgta gccgttcgcc tgactcggtc
    17341 tgccgccgtg gccgtcgagg tgcgtctcgc cgtatccgac ggcgacgagc aggtcacggg
    17401 gcacgtcgaa ctcggtggcg gccttctcga acgcggtgtt catcgcgccg gagccggctt
    17461 cggtgccggc gccaccgggg tacggcgcgg ccgtcgccgg ctggccggcg agggccagcg
    17521 acgcggcgac cacgctgccg aggagcgcgg cccggccgcg cttccagcct gtcttgcctg
    17581 tcatcaaggt catcgatctg ctctccgctc agtggtgcgc gggtccggga cctgtgcgca
    17641 caagtggggg caaggcgggg tgaggagctg tcaactcctg gggtatacag gtgacttgag
    17701 gagtggtgcc gggtgggggc tgtgggggtg gggcaggcgg gacgtactct gccgcaccgg
    17761 cggcaccgac gccatgatgg agcgccgact tgtcaggagc aagacatttc atctccgacg
    17821 aaacgcgctg tccagtcgtt gtgggacggt gcgcccgtcg ctacttttgc cgggtctcgc
    17881 agcggtcgcc ggcccgcccg ccgatcggct gcttccccca cacccgggag cattcgtgac
    17941 ccgtctcaga cgcctatcga ccacattcgc cggtgtgctc ctcgtactag tcgggatgct
    18001 gacggtaccc gctgcggcgg ccgaagcggc cgaagcgggc acctccgaca cggccgccga
    18061 ggcggcgggc cccaacttca aggcgcccta cccgtgcggg cagcggtgga cctacagcca
    18121 ccactccgcc gaggtccgcc gtgcgctcga cttcgtacgg gccgacggcg gcaccaccaa
    18181 cggcactccg gccctcgcgt cggccgccgg tacggcgacc cggcacagcc agccgagcgg
    18241 cgcgggcaac tacatctcca tcgaccacgg cggcggctgg aagacgtact acttccacct
    18301 cggctccttc tcggtggcca gcggacagtt cgtcaaccag ggccagcaga tcggcaccac
    18361 gggctccagc ggcaactcct cgggccccca cctgcactac gagcagctgc tcaacggcgt
    18421 cggacagaac atcgtcatca acggtggcgg cctgccctac cccggcagct acaaccagca
    18481 cttcctcacc agcgacaacg gctgcggcgg cggaggcggc ggtaccccct tcaccacctg
    18541 gggcaccgat gtcagcgtcc gcgccgacgc ccggctgaac gcggccgtcg tgacccggct
    18601 ggcaggcccc acgaacgtcc acgtcgtgtg ccagaagcag ggcgacaccg tgaacgccga
    18661 gggttacacc aacaactggt ggagcaagct gcgcgaccag ggcggcttca tgtcgaacat
    18721 ctacatcgac catccggccg cccaactccc cggcgtgccg ctctgctgac aggtacatcc
    18781 gcgcacgggc gcgaccggcg gctcaggagg gcggcgccca ccgagccgcc ggaccgctcg
    18841 cccccgaccg cccggacccg caggaccggc cggtcgccgg gtacttcacg gacgcggcgc
    18901 cccgttcagc cccagaccag cacgcccagc cacgtacccg ccacgagcag gcagcagaac
    18961 agttcgacca gtaccggaac gcccgccgag cgcatcaccg cgcgcgtcga ggcccagccg
    19021 tcgcggtggc tgcccagccg tacccgttcg accgcgtaga tccccccgac gaacgccggc
    19081 gccgtgccca ccaccggcac cacgaagaag cccacgatcc cggccagccc gcccgccagc
    19141 agagtgcgcc ggcgggtgcc ggtctcgcgt gtgcggcggg acggcagcag gggtctgagc
    19201 gcctggttga gcagcagcag cgccgtggcg gcgatcagta gcgcccaggc cgtcaccgag
    19261 gtgtcgctca gcgcccacca gaccacggcg gcccagacga tggcgggccc cggcaccccc
    19321 ggaatcagca caccgaggac gcccagcagc atgaccagac ccaccagcac gagctgccac
    19381 acgtccatct gccaagagtg caggatcccg cccggagtgg cacgcggacg attcgccccc
    19441 cgtgtcctca ctcccgcagg tcgcgggcca cccagccctt ctcgtacgcg tgccagccca
    19501 gctggagccg cgtcgtcacg cccgccagct ccatcagggc cttcacccgg cgctgcacgg
    19561 tccgcagccc cagatcgagc tgcttggcga cgctcgcgtc cgtcatcccc gcgagcagca
    19621 gggacagcac ctccagatcg gtctcgcccg gcccctcggc cgcgtcctcc acgaccgccg
    19681 ccccgtcccc gccggggacc agccgcagcg gcagcgcgtc gcgccacacc gcctcgaaga
    19741 gccccgacag tgactccagc agcccgctcg agtggacgac cagggccgcg ggctccgcgt
    19801 cgccccccgt caacggcacc atcgccaggg cgcggtcggc gatcaccagc ttggtcggta
    19861 cccggtcgac cacccgtacc tgctcgtcac ggccgagcgc cgccgacagc tcggtgatcc
    19921 cgtccggcag cgacagcacc tcgcgctcga tcaccacgcg gtagcggaca ccgcgcgtca
    19981 ccacccgctc ctcggactcg ttgtcgacac ccgtcaccac cacgggcctg ccggtgacca
    20041 gcgcccgtat ctcctccgtc gcccccagct ggagctggtg gaaacggtgc gccaccgcgc
    20101 tggcgcccgt caccacctcg accagatcgt gcacggcggg acccgccgac tcggcgcggt
    20161 actcctccgc gagcagtacg gcggccagct cggcccgctc cagctcgtgg cgctgctggg
    20221 tgagcagcgc gcccagcgcc acggcgggcg gcgcggccac ccagcgcccg gtgcgggccg
    20281 acgactgcgc ggccagtccg tgctgctcca gccggcgcag cgcgcgctcg gtgtcctgct
    20341 cgggcatcgc gagccgatgc gccagatcgg ccgcgtcggc ggcgccgagc gccaccagcg
    20401 cgcggtacgc cgattcctgt ctctcgtcga gacctatcgc tcccagcacc cctgcacccc
    20461 tccccggacg gacgttcaaa cccggcgggg cgtggcggat accggccacg gcgtaaaccc
    20521 gccgcgcaca tcatccccgt accacgcgtc actctgccaa tgtggcgaca ttgcgggatc
    20581 ggcagacgtc agggatatgc ccgggtcgcg tcggtgcgtg tccgcccccc gtacggcgga
    20641 tcctcgtatg ccggataagc tgactacccg gacgttcccg tcgaaccccg acgagtcgct
    20701 acgattcgaa tcggcgtacg gttgacaccg aggccggtct ccggccccga atcctggtcg
    20761 gcgcacctgg tgcgttccgg cctgccgaac gtccgccggg cgtccttccc gtggggggtg
    20821 gggtcgcccg gcggacttgg gccgcgcggt cgtgacgtca tcgcgccacg cctcctactt
    20881 tttcggggtg tcccgttttc tgacgcctcg tgcggtcgac aataggagca tgagccagca
    20941 gggggaccgg cccgccacca ccgacgactg gtggggccgg ctgtacgacg agtccgcacc
    21001 cgacaccggt ccggccgagg cgccggacga cacgatcgag gaccgtttcg actcggcggc
    21061 ggacacgctc ggcgccgagg gcgccgcgga cgcgaccaca cgggcggggt acgggcgggc
    21121 ggtcgacgcg atcggtgtgg acgacgagga ggacgcgggc gacgaggacg aggacatgga
    21181 cgtgggagcc gccgccggcg gcgggcccgt ctcgcggccg atggcctggt gggaggcgcg
    21241 cggcgcctac ccggtgatcc aggcgcccgc gcccggaccg gcgtcaccgc ccacgaccgt
    21301 cgacaggccg ggggcggccc ccgcgccccc gcccgcgcag gctccggcgc ccggccccgt
    21361 cgcgccggcc cctctcacac cccggccacg ggcaccgtgg gagccgccgc ccgccgcgtt
    21421 cgatcccggc cccgccggac cgctgccgga cgccgccgat ccggcgccgc cgccggtcac
    21481 caccccggtc cggaccccgg ccccggatcc gcgcgccgcc gcccccgagc cgccggttcc
    21541 tccccggccc gcgcccaagc ccgcccccgc tcccgccgcc cctgtcaccc acgtcggcga
    21601 cgggccgccc acctacgacg acgaacccac cgcgctgccc gccgccgaag ccgaggaact
    21661 cggccaactc gtcgccgaca ccgtgctcga cggtgcccgg tacggcacgt acaccctgcg
    21721 cgccgcctcc atgcgcggcg attcggcgcg ctaccggggc gagccccgca gggacgcgct
    21781 gctcaccgcc cgcttcggcg ccggcgcgag cgccctcgtc ctggtcgccg ttgccaccgg
    21841 cgcgcgcgcc accgagggcg cccacctgtc cgccgccgac gcctgccgct ggatcggcgg
    21901 cgcggtcggc cgcagttgcg accggctcgc cgaggacata agagcgggcc gccgcggcga
    21961 cctgaaatcc ggactgcacc ggctcaccga ccgtacgtac ggcaagctgc gcgcccgcgc
    22021 ggccgagttg ggacgcgaac cggaggacta caccgcgagc ctgcgctgtc tgctgctctc
    22081 cgccgacccc gagtgccgga cccgcgtctt cttcggcgtc ggcggcggcg ggctcttccg
    22141 gctcagggac ggcgcctggc aggacctgga gccgctcctc cccgaaccgg ccgacatcag
    22201 gggcgagccg gtcctcggtt tcggctcccc ccggtccgac gccgaagaac agacgcccga
    22261 gggtgaccgc ctcacgatgg atctggagat caccaagcct ccgggaccgg ttgtcgagga
    22321 tcccgttccg ccgcctccgg agccgttccg cttccgggcc tcggtcgccc gtccgggcga
    22381 cacactgctg ctgaccagcg tcgggctcgc cgagccgctg cgcggtgaac cggccctggg
    22441 cgacgagctg gccgcgcgct gggcgtccgc cgagccgccg gggctcgccg agtacctgtc
    22501 ggacgtccgg ctgcgggtga agggttacgc cgacgaccgt acggccgtgg cggtctggga
    22561 ggcgtaaccg cgcggggcgt gggttgatgg acaccgggtc tcggagggga ccccggtccg
    22621 cgtcccgccg gcccggcatc ccccgacagc agaagggcgc ttccatggcc aggcagaacg
    22681 tggcggagca gttcgtcgac atcctcgccc gcgcgggcgt gcggcgcctg tacggagtcg
    22741 tcggcgacag cctcaacccc gtcgtcgacg ccatccggcg caacgccgcc atcgactggg
    22801 tgcaggtcag gcacgaggag gcggcggcct tcgcggcggg cgccgaggcc cagatcaccg
    22861 gcaagctcgc cgcctgcgcc ggctcctgcg ggcccggcaa tctgcacctg atcaacgggc
    22921 tgtacgacgc gcaccgctcg atggccccgg tcctggcgct cgcctcgcac atccccaccg
    22981 cggagatcgg cctcggatac ttccaggaga cgcaccccga gcgattgttc gaggagtgca
    23041 gccactacaa cgagatgatc tccagtcccg agcagatgcc ccggctcgtc cagacggcca
    23101 tccagcacgc ggtcggccgg ggtggtgtga gcgtggtgac gctgcccggc gacatcgcgt
    23161 cgcggccggc cccgacgaag gcgatcgagc acgccctggt gacgtcccgg ccgacggtgc
    23221 gacccgggga cctggagatc gacaagctgg tcgacatgat cgacgacgcg gaccgggtca
    23281 cgctcttctg cggcagcggt acggcggggg cgcacgcgga ggtcatggag ttcgccgagc
    23341 ggatcaagtc cccgatcggc cacgccctgc gcggcaagga gtggatccag tacgacaaca
    23401 ggttcgacgt cggtatgagc ggactgctcg gttacggcgc cgcctacgag gccacccacg
    23461 agtgcgatct gctcatcctg ctcggcaccg acttcccgta caacgccttc ctgcccgacg
    23521 gcaccgacgt caagatcgtc caggtcgacg tccggcccga acgcctcggc cgccgctccc
    23581 agctggacct cgccgtctgg ggcgacgtac gcgagacgct gcgctgtctg acgccccggg
    23641 tgcggatgaa gagcgaccgc cggttcctgg acaagatgct caagaagcac gccgacgcgc
    23701 tcgaaggcgt cgtcaaggcg tacacccgca aggtcgacaa gcacgtcccg atccaccccg
    23761 agtacgtcgc gtccgtgctg gacgaagtgg ccgacgacga cgcggtgttc accgtggaca
    23821 ccggcatgtg caacgtctgg gcggcccgct atctgtcgcc caacggccgc cgccgggtga
    23881 tcggttcgtt cagccacggg tcgatggcca acgccatggt gcaggccgtc ggcgcgcagt
    23941 tcgtggaccg ggagcgccag gtcgtctcga tgtccggcga cggcggattc accatgctga
    24001 tgggtgactt cctcactctc gtgcagtacg aactccccgt gaagatcgtc ctgttcaaca
    24061 actccgcgct cggcatggtc gagctggaga tgctggtggc cggtctgccc tcgtacggca
    24121 ccaccaaccg caaccccgac ttcgccgccg tcgcccgcgc cgccggggcg ttcggggtca
    24181 gggtggagaa gcccaagcaa ctcgcgggcg cgctcaagga cgccttcaag cacaagggcc
    24241 cggccctggt ggacgtggtc accgacccga acgccctgtc catgccgccg aagatcagcg
    24301 ccgacatggt ccagggcttc gcgctctcgg ccgggaagat cgtgctggac ggaggggtgg
    24361 gccgcatggt ccagatggcg cgctccaacc tgcgcaacct gccgcggccc tgacccctcc
    24421 caccgctgtt cctacgcggg cgtgaaccgc agtgtgagaa tctggaacgg gcgcagtgac
    24481 acccgcaggc cctccgcacc cgttcccgcc tcgtgcagcg gtcgctccag caggtcggtg
    24541 acctgggcct gtacgacggg gaaaccggtt cgcagcaggg ccgacgcgcg gttgcccgcc
    24601 gactcgtaga gccggaccac cacatcgccg ctacggtcct cggcgagctt caccgactcc
    24661 accgtgaccg ccgggtggtc gacggagacc agcggcgccg acgcgggagc ggcggcgacc
    24721 cgcagcggca ggttgagcgc cagcccctcc cgtaccgcgt ccgtcacctc ggcgcccggc
    24781 gccagcgcgt agctgaaccg gtgcgtgccc aggtccgtct ccgggtccgg gctgtgcggc
    24841 gcccgcagca gcgtcagccg caccgtcgtg cccagcccct cgtcgtgctc ggtgcgggtc
    24901 acgtcgtggc cgtacgtcga gtcgttgacc accgccacgc cgtagccggg ctcggcgacc
    24961 cgcagccagc ggtgcgcgca gatctcgaac cgggccgcgt cccaactggt gttggcgtgc
    25021 gtggcacggt gcacatgacc gaactggatc tcggcggtgg a
//
