LOCUS       NZ_CP048397            22277 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. S4.7 chromosome, complete genome.
ACCESSION   NZ_CP048397
VERSION     NZ_CP048397.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S4.7
  ORGANISM  Streptomyces sp. S4.7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.
  TITLE     Viennamycins: new lipopeptides produced by Streptomyces sp. S4.7
            isolated from the rhizosphere of Edelweiss (Leontopodium nivale
            subsp. alpinum)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2020) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.8x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010384365.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 10:27:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,027
            CDSs (total)                      :: 6,939
            Genes (coding)                    :: 6,650
            CDSs (with protein)               :: 6,650
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 289
            CDSs (without protein)            :: 289
            Pseudo Genes (ambiguous residues) :: 0 of 289
            Pseudo Genes (frameshifted)       :: 103 of 289
            Pseudo Genes (incomplete)         :: 223 of 289
            Pseudo Genes (internal stop)      :: 23 of 289
            Pseudo Genes (multiple problems)  :: 52 of 289
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:05:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3581738
            Orig. end                         :: 3604015
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048397.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zotchev Lab, University of
            Vienna, Austria.
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22277
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22277
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22277
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12277](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12277)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    71..86
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            complement(339..851)
                     /locus_tag="SSPS47_RS15800"
                     /old_locus_tag="SSPS47_16010"
     CDS             complement(339..851)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010352181.1"
                     /locus_tag="SSPS47_RS15800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16010"
                     /product="hypothetical protein"
                     /protein_id="WP_239064926.1"
                     /transl_table=11
                     /translation="MPQPQRREITYTDELLADRTVHRRYSDGGQEWRSAVGGGGRVVQW
                     RDERGGSGTDELLGGRIVKRVHTNGRRPIYGREAGYGRTLWSDGVLTVNRTSFGGRLGT
                     VLGAVTAGAVIGGLTLPPAFLSPEEEEELRRQAEASSSGGGGDGGGGDAGYGDWGDGSG
                     DSDDDFG"
     gene            complement(863..1792)
                     /locus_tag="SSPS47_RS15805"
                     /old_locus_tag="SSPS47_16015"
     CDS             complement(863..1792)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386556.1"
                     /locus_tag="SSPS47_RS15805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16015"
                     /product="hypothetical protein"
                     /protein_id="WP_164251663.1"
                     /transl_table=11
                     /translation="MRDSGQAGRTRPVGDAILDRVLRTAAEKAAEPGQLRFTERQLYYE
                     VCRVLMPWHRAPRRAQFTSAPALTYEAYLAALRRHGPGSVGGLLPPVVPKPRQAAGRHT
                     PEPDLFDYGLPRLLVCESDDIAAMLRANGVPMESACPVYGASELPLAEGMLRMLALAER
                     ATVYLLHDASARGLTFPARFAGAVDVPEGVRVVPLGLRPRQAGALHLVHGRGPAYAAVP
                     AAFPTAGSGLGPGPGAGRGPGRGVAFELGRWERDWLRRGRFVEVAAVNPASLIRTVHRL
                     VREVRTPRSQLTELRQVRRAGFLSWPTA"
     gene            complement(1789..2868)
                     /locus_tag="SSPS47_RS15810"
                     /old_locus_tag="SSPS47_16020"
     CDS             complement(1789..2868)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSPS47_RS15810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SSPS47_16020"
                     /product="hypothetical protein"
                     /protein_id="WP_164251664.1"
                     /transl_table=11
                     /translation="MICPHCEKSLRYRERGGTTCSVCKRTFALEPKGNALRLHDIRMRK
                     LIEKLGNGEGLRYTPTQLWYAAARNHTPTGAVAYGCIASFLVVLTSFILLVVSDASDFD
                     PDVVRPAVVVGVVVLALALLLTAGGSRSAKRTGTVQVPMPLDMFRTAIIDRWAAVYGGP
                     PAGLRQEGSARYPVVPASGGPGPRLALLCPDRAVLTCLSLNGAHKTHSLALAQSLDQLG
                     NISTGPTPPGEGGVVGIVLHDASPAGLAFASAARAALGGRVVVAGMLPRTVMDKDNAVR
                     LRKPLDPGDLDAIRTSSSALTAAEADWLTRGWWSPLAAVPPAKLLAVVARAVDRAEGLA
                     DPDRGRAQQVGFLTWPTAS"
     misc_feature    complement(2939..2954)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.47"
                     /tool="antismash"
     gene            2973..3692
                     /locus_tag="SSPS47_RS15815"
                     /old_locus_tag="SSPS47_16025"
     CDS             2973..3692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386558.1"
                     /locus_tag="SSPS47_RS15815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16025"
                     /product="hypothetical protein"
                     /protein_id="WP_164251665.1"
                     /transl_table=11
                     /translation="MKHEANAENEVHDVAEFTDAARNVVTPVLQLPEDIALAVVNAFTK
                     IVRDAKRSESATMPDSDGITRFQTFEEGDVYMLEAPFDDFFADRYLMDFYNVEERGVCS
                     RMHMHTGLRFVRMMTGPATRIRVSSLSPFETTGVTGVTPFTLHSFEDTLPDTPPGVVRT
                     RYNLVVPPCSFVDMQIPRGVSHQFNAVGEHAVIDSVHPEESVETFREKISGFKMMAQTV
                     FLADELPASDTCANLPA"
     misc_feature    complement(2993..3007)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     gene            complement(3704..4420)
                     /locus_tag="SSPS47_RS15820"
                     /old_locus_tag="SSPS47_16030"
     CDS             complement(3704..4420)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377965.1"
                     /locus_tag="SSPS47_RS15820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16030"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_164251666.1"
                     /transl_table=11
                     /translation="MSTRARILEVAARLVAESPNGDVSTRAVCDAAQVGAPALYRYFGD
                     KEGLLSAVVDYGFDRYLETKRQRAPEDDPIEDLRKGWDSHVEFALDNPNLYRLMYSPAM
                     RTPPAAALESHEILTRDLRRAAADGKLRLAPEAAAQVVMSANVGVALMLVARPTTFTDR
                     DTSRRVRDSVHATVFTPEVMADSPARAAARTQLPAAAAQLNVLLGRSAESGLSTAEVAL
                     MTEWLRRLSTTSENDG"
     gene            complement(4741..5487)
                     /locus_tag="SSPS47_RS15825"
                     /old_locus_tag="SSPS47_16040"
     CDS             complement(4741..5487)
                     /NRPS_PKS="Domain: PKS_KR (10-170). E-value: 1.3e-18.
                     Score: 59.5. Matches aSDomain:
                     nrpspksdomains_SSPS47_RS15825_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129233.1"
                     /locus_tag="SSPS47_RS15825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16040"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_164251667.1"
                     /sec_met_domain="adh_short (E-value: 5.7e-38, bitscore:
                     129.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQPSTARRVVIVTGGSRGIGRESAERLAADGHAVVVNYAGNRT
                     EAEAAVAAITGAGGTAMAFRADVADEVAVSALFDAAEEAYGGVDVLVHAAGVMSVTPLV
                     DTELDALDRMHRTNIRGTFVVDQQAARRLRSGGAIINFSSSVLGLSFPGYTAYAASKGA
                     VEAMTLILARELRGRDITVNAVAPGPTATALFLDGKDEETVSKLAAQPPLERLGRPEDI
                     AEVVSFLAGPARWVNGQVLRANGGII"
     aSDomain        complement(4978..5457)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SSPS47_RS15825_PKS_KR.1"
                     /evalue="1.30E-18"
                     /label="SSPS47_RS15825_PKS_KR.1"
                     /locus_tag="SSPS47_RS15825"
                     /protein_end="170"
                     /protein_start="10"
                     /score="59.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVIVTGGSRGIGRESAERLAADGHAVVVNYAGNRTEAEAAVAAIT
                     GAGGTAMAFRADVADEVAVSALFDAAEEAYGGVDVLVHAAGVMSVTPLVDTELDALDRM
                     HRTNIRGTFVVDQQAARRLRSGGAIINFSSSVLGLSFPGYTAYAASKGAVEAMTLI"
     CDS_motif       complement(5383..5454)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SSPS47_RS15825_0001"
                     /evalue="4.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="SSPS47_RS15825"
                     /protein_end="35"
                     /protein_start="11"
                     /score="19.4"
                     /tool="antismash"
                     /translation="VIVTGGSRGIGRESAERLAADGHA"
     gene            5822..6238
                     /locus_tag="SSPS47_RS15830"
                     /old_locus_tag="SSPS47_16045"
     CDS             5822..6238
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645725.1"
                     /locus_tag="SSPS47_RS15830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16045"
                     /product="YciI family protein"
                     /protein_id="WP_164251668.1"
                     /transl_table=11
                     /translation="MKYLVMVQGSQADYDAMNGKASEHSAAWSEKDLQAMFAFMGEINN
                     DLAESGELVDANGLAAPSQTRLVGADKDGKPVITDGPYGETKELLAGYWVLDCAGLERV
                     TEIAARVATCPQPEGVPVYPVVIRPIPDGPGVDG"
     gene            6281..7552
                     /locus_tag="SSPS47_RS15835"
                     /old_locus_tag="SSPS47_16050"
     CDS             6281..7552
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018488488.1"
                     /locus_tag="SSPS47_RS15835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16050"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_164251669.1"
                     /transl_table=11
                     /translation="MKDGTKNGPGPPARPATTEDLLRLHAPQVLGALVRRYGHFDLAED
                     AVQEAFIAASQQWPAAGPPDNPRGWLIKTASRRLVDQLRSEEARRRREENAAALAPRDT
                     FTAPPPGESRAPSEDDTLTLLFLCCHPELPAAGRTALTLRAVGGLTTAEIARAHLVPEA
                     TMAQRISRAKQKIKGVPFRQPGPEDRDRRLATVLQVLYLIFNEGHTATSGSELHRADLA
                     HEAIRLTRAVRRLLPADGAVTGLLALMLLTEARSAARTGPHGELVPLDEQDRTRWDRAA
                     IAEGTALVEESLSQGPAGPYQLQAAIAALHDEAASAEETDWLQIVALYDELVRRAPGPE
                     PMAELSRAVAVAMAHGPEAGLAELKGLEKELSGNHRLDAVRAHLLEKAGDTEGALAAYR
                     AAANRTLSVPESRYLMMRAARLRA"
     misc_feature    6307..6321
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     gene            complement(7624..9900)
                     /locus_tag="SSPS47_RS15840"
                     /old_locus_tag="SSPS47_16055"
     CDS             complement(7624..9900)
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="SSPS47_RS15840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16055"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_164251670.1"
                     /sec_met_domain="Pkinase (E-value: 1.3e-51, bitscore:
                     174.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGRLLSGRYELGELLGAGGMGEVWRARDRELGREVAVKLLLAPG
                     GDGERREQLARFRREARAVASLDSPHIVAVHDHGTDGDSPYLVMALVDGRTLHDVLAES
                     GRATVADALGWAIDVCRGLEVAHAAGIVHRDIKPANIMVTGEGVAKVVDFGIAKYTEAR
                     SSDPQLTRTGQAPFGSVLYMAPERFQQRNGDGRTDLYALGCVLYELLVGRPPFVGHAAG
                     IMYNHLNDEPLRPSRARAELGPEMDRLILSLMAKDPDDRPSDARAAREALESARSSLEG
                     AREESGGEPEAAAVAVVAAAPEPEDERPATPAPVAAPAPAAPRPHFVAKVSTPPPAPVR
                     RRPRNALVAAAVALVVLGIPTGLVISSSSSSSSSSGGSVPADGPSAAVADQYVVGVPYD
                     WSLDERHGEERAAIVEAAFKDAARASGGKLPVRVVPVKDDRETPATEMLKKYPGMIALV
                     GDVNSVDGVETEFDRDMAAVDTCNGSSGPDFAFGTMPSKFDMGRQEGRYLTGAYGVQKV
                     IVGSDFNWDDDIIAEDDPHRRTLGQGLREAGIDAVEAVDYPEDMDEEDVARDVGKQRPD
                     TVTLPNARQREGWVDALEKSGQLMVVQEDYEASCDTDEDHEYTDREDKLVPDGTLRFRS
                     FHDERQPKADCGPFPKVCSSPAALRKMFQARGGAELYDGALVLAAGIGKVMDDGALPEP
                     DGTTDTDPGVARASLREAVGGVDVEGVLGRYRFKDHQAVSRPVWIDVREKGEWKQLGTV
                     GSLSG"
     gene            complement(10001..12277)
                     /locus_tag="SSPS47_RS15845"
                     /old_locus_tag="SSPS47_16060"
     CDS             complement(10001..12277)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515109.1"
                     /locus_tag="SSPS47_RS15845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16060"
                     /product="terpene synthase family protein"
                     /protein_id="WP_203557854.1"
                     /sec_met_domain="T1TS (E-value: 7.7e-83, bitscore: 277.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPFELPDFYMPYPARINPRLEEAREHSRRWARDMGMLEGSGIW
                     EQSDLDAHDYALLCAYTHPDCTGPQLSLVTDWYVWVFFFDDHFLEIFKRTQDREGGKAY
                     LDRLPAFMPMDLADGFPEPTNPVEAGLADLWRRTVPSMSLDWRARFAESTENLLNESLW
                     ELANINAERISNPVEYIEMRRKVGGAPWSAGLIEYAAGAEVPAEIADSRPMRVLRDTFS
                     DGVHLRNDLFSYQREIEEEGELSNGVLVLETFLKCTTQEAADAVNDLLTSRLHQFENTA
                     LTELGPLFVEKGVDPVAAAGTLAYVKGLQDWQSGGHEWHMRSSRYMNGAEAGKGAAAGE
                     TAGPLFSLTPVGRGTAASDYLKSLTNGSPARARSHSHVPYQRVGPSILPAFEMPFEARL
                     SPHLEAAREHSVEWARRMGILEGQPGIPGSDVWDEDRIRRIDVPLCAAGIHPDATPEGL
                     DLTSDWLAWGTYGDDFFPVVYGNTRNLAAAKVCNERLSLFMPIETLDTPPPLSALERGL
                     ADLWLRTAGPMDVDSRRAFRASVEDMTASWVWELTNQIQNRIPDPVDYIEMRRATFGSN
                     MTMSLCRIGHSDAVPPEIYRSGPMKSLENAAQDYACLMNDLFSYQKEIEFEGEVHNGVL
                     VVQSFFNCDYPTGVAIVHDLMKGRMRQFQHVAANELPVLYDDFALDAEVRAVLDGYVKE
                     LENWLSGILVWHDGCHRYKEEDLLHDRAGITRWLPPTPRGPGTSATRIQLPSPASATEA
                     KALTP"
     gene            12443..13057
                     /locus_tag="SSPS47_RS15850"
                     /old_locus_tag="SSPS47_16065"
     CDS             12443..13057
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985600.1"
                     /locus_tag="SSPS47_RS15850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16065"
                     /product="HhH-GPD-type base excision DNA repair protein"
                     /protein_id="WP_164251671.1"
                     /transl_table=11
                     /translation="MSTTIRIAQQPEADELLGRSPLAALVGMLLDQQVPMEWAFSGPYA
                     IAVRMGGDDLDARAIATYDPAAFAALLSEKPAVHRYPGSMAKRVQQLCQFLVAHYDGDA
                     AAVWKDAATGAQLFKRLTELPGYGKQKSQIFLALLGKQYGVRPEGWREAAGAYGDEGSY
                     RSAADITGPETLAKVRAHKQEAKRAAKAAKTAMSPPSRAKG"
     misc_feature    complement(13138..13156)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.58"
                     /tool="antismash"
     gene            13203..14753
                     /locus_tag="SSPS47_RS15855"
                     /old_locus_tag="SSPS47_16070"
     CDS             13203..14753
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946164.1"
                     /locus_tag="SSPS47_RS15855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16070"
                     /product="M28 family metallopeptidase"
                     /protein_id="WP_164251672.1"
                     /transl_table=11
                     /translation="MAVAAATALAAPLLLSASSASAHNRPDPAKDASKLSKKLVKEASG
                     KDAYKHLKKFQDIADSAGGHRAAGSLGHDASAAYVYSLLKKAGYDVSYDSFEFTYIETQ
                     AETLKVTAPTPRDSQITAMSYTKSTPEGGIEAGLAVVPVDATTGCEATDYAAGAFTGKI
                     ALIQRGGCDFATKQQMAAGAGAVAAIVSNNTEGALSGTLGDPAAARIPTGGITQAEGAK
                     LAAEAAAGPVTVSLDIRQLQEERTTRNVIAETKGGDTANTVMLGSHLDSVTEGAGINDN
                     ASGSAGLLEVALDLAKSREKTANKVRFAWWSAEELGLLGAEDYVKGLSPEQAEQIKLYL
                     NFDMIASPNFGQFVYDGDDSDAVGEGPGPEGSAQLEKGITDFLDSKDHPHEGTDFTGRS
                     DYGPFIEVGIPSGGTFTGAEGIKTEAQAAKFGGEAGVAYDPCYHAACDDLDNINKEAFD
                     VNIDVIADAVGQYAHDLSPLTAKAKAQATAKTERTTGGDTGVGASNAHDHEHGHETRS"
     gene            15003..15305
                     /locus_tag="SSPS47_RS15860"
                     /old_locus_tag="SSPS47_16075"
     CDS             15003..15305
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949502.1"
                     /locus_tag="SSPS47_RS15860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16075"
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_023540426.1"
                     /transl_table=11
                     /translation="MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKGQLDL
                     ETLLAEDSTFYGDLFAHVVKWQGDLYLEDGLHRAVRAALQQRQVLHARVLELDLG"
     misc_feature    complement(15015..15031)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.99"
                     /tool="antismash"
     gene            15481..16122
                     /locus_tag="SSPS47_RS15865"
                     /old_locus_tag="SSPS47_16080"
     CDS             15481..16122
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005315293.1"
                     /locus_tag="SSPS47_RS15865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16080"
                     /product="LytR C-terminal domain-containing protein"
                     /protein_id="WP_164251673.1"
                     /transl_table=11
                     /translation="MSMLTPPGMGGKYRITGAKYPRMRRPRNRRRIVLAAIATVVALGL
                     AGWGTVQLIDVFTADDGSAKKTTTASGRQPDCRPSPSAAPVKTLPKPAQITVNIYNATP
                     RAGLAKTTADELKKRGFVIGKVGNAPAAFDKKIPGTGILLGAPAAADSSFTVLGAQLKG
                     AKPQHDERKTKDVDLLLGTAFKSLSVQKDAERALAVLTRPSPGGTCDHKG"
     gene            complement(16187..16822)
                     /gene="upp"
                     /locus_tag="SSPS47_RS15870"
                     /old_locus_tag="SSPS47_16085"
     CDS             complement(16187..16822)
                     /EC_number="2.4.2.9"
                     /GO_function="GO:0004845 - uracil phosphoribosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="upp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006141414.1"
                     /locus_tag="SSPS47_RS15870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16085"
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="WP_164251674.1"
                     /transl_table=11
                     /translation="MRIHVVDHPLVAHKLTTLRDKRTDSPTFRRLADELVTLLAYEATR
                     DVRTEQVDIETPVKPTTGVKLSYPRPLVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRN
                     EETLQASTYATRMPEDLSGRQVYVLDPMLATGGTLVAAIRELIGRGADDVTAVVLLAAP
                     EGVEVMERELAGTPVTVVTAAVDERLNDRGYIVPGLGDAGDRMYGTVD"
     gene            17111..17302
                     /locus_tag="SSPS47_RS35425"
     CDS             17111..17302
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521932.1"
                     /locus_tag="SSPS47_RS35425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_239065276.1"
                     /transl_table=11
                     /translation="MPDPPPVPTAELDSDESAAARRRRRAQFLRELNEAKALRERVKPR
                     QARAARMRQQMRMRTFRW"
     gene            17556..18107
                     /locus_tag="SSPS47_RS15880"
                     /old_locus_tag="SSPS47_16095"
     CDS             17556..18107
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018101781.1"
                     /locus_tag="SSPS47_RS15880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16095"
                     /product="hypothetical protein"
                     /protein_id="WP_147878115.1"
                     /transl_table=11
                     /translation="MYFAALLARTEDGWAASDTELDDVETLSDLTDLAREASVDEDTVL
                     VFIEQEDAWFGVLRVEGEEDPRIYVSDAAMAARSSYGEILTDELLGGDDDLDDALDTLD
                     LDGTEDGETEEQEDTDDRDDSTGTAVAAGPGTVPAGPAGDRGILADLGLSEAELLALET
                     DAMSEIADALGASEVLETAR"
     misc_feature    complement(18150..18164)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            18185..18628
                     /gene="tadA"
                     /locus_tag="SSPS47_RS15885"
                     /old_locus_tag="SSPS47_16100"
     CDS             18185..18628
                     /EC_number="3.5.4.33"
                     /GO_function="GO:0008251 - tRNA-specific adenosine
                     deaminase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0002100 - tRNA wobble adenosine to inosine
                     editing [Evidence IEA]"
                     /codon_start=1
                     /gene="tadA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240: riboflavin biosynthesis protein RibD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019887718.1"
                     /locus_tag="SSPS47_RS15885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16100"
                     /product="tRNA adenosine(34) deaminase TadA"
                     /protein_id="WP_164254605.1"
                     /transl_table=11
                     /translation="MRLALEEAARAAPSGDVPVGAVVLSPDGSVLSVGHNEREMTGDPT
                     AHAEVLAIRRAAAELGAWRLTGCTLVVTLEPCTMCAGALVQSRVARVVYGALDEKAGAA
                     GSLWDVVRDRRLNHRPEVVHGVLAEECSRLLTDFFRDRRVIDF"
     tRNA            18660..18747
                     /anticodon=(pos:3600432..3600434,aa:Ser,seq:cga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="SSPS47_RS15890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SSPS47_16105"
                     /product="tRNA-Ser"
     gene            18660..18747
                     /locus_tag="SSPS47_RS15890"
                     /old_locus_tag="SSPS47_16105"
     gene            complement(18816..20099)
                     /locus_tag="SSPS47_RS15895"
                     /old_locus_tag="SSPS47_16110"
     CDS             complement(18816..20099)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007501842.1"
                     /locus_tag="SSPS47_RS15895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16110"
                     /product="site-specific integrase"
                     /protein_id="WP_164254606.1"
                     /transl_table=11
                     /translation="MEDESKKKRTRQPNGRSSIYLGADGKWHGRVTVGIRDDGTPDRRH
                     VKRKTRAEVTEAVRELERQRETRTTRKPGRAWTVTTWLTHWIESIAPLAVNENTAAGYG
                     YAVRKHLIPGLGAHRLDRLKPEHIERFYASMQQRGSAPATAHQVHRTFRTALNEAVRRG
                     DLGQNPVRLAKAPRLRDDEVEPFTVEEIRRLLRAADEGRNSARWAVALSLGLRQGEALG
                     LKWADVDLKRGVLMVRRSRRRPRYAHGCGDTCGRKPGYCPERQRTNPETADTKSRAGRR
                     AVGLPPQLVDLLRTHRDRQETERAAAGGDWTEEGWLFPTATGRGTSPRTDYDDWKELLG
                     RAKVRDGRLHDARHTAATVLLILGVPERAVMGLMGWSSTAMAARYQHMVDTVRTGVAAQ
                     VDGFIWESGNDGSDDDDDGASGALVTTN"
     gene            complement(20111..20338)
                     /locus_tag="SSPS47_RS15900"
                     /old_locus_tag="SSPS47_16115"
     CDS             complement(20111..20338)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007497374.1"
                     /locus_tag="SSPS47_RS15900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16115"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_164251675.1"
                     /transl_table=11
                     /translation="MSPAPTDNDQTLVLLTVEEAARRLSIGRTVCYRLIRSGELESFTL
                     GGLRRIPADAIPEYVTRRRQSYRTVAAQAA"
     gene            complement(20649..22178)
                     /locus_tag="SSPS47_RS15905"
                     /old_locus_tag="SSPS47_16120"
     CDS             complement(20649..22178)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020113732.1"
                     /locus_tag="SSPS47_RS15905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_16120"
                     /product="YfjI family protein"
                     /protein_id="WP_164251676.1"
                     /transl_table=11
                     /translation="MSTTDLWEGFDALDPETITGPVWDEPVPLSARRELPAFPVDALPD
                     WLRNMASEVAEETQTPVELAGCLALAVIATAAGGRATVCVRGHWREPVNIYTAVALDPG
                     NRKSAVFGLMVDPLLAVEKMLVELSAPVRAEAETTAKLAKAAAEKAAQKAASAEPEKRD
                     ELTADAVSLAQTAESLSVPAVPQLVADDVTPETIGSLLHGQGGRISVMSAEGEIFDIMA
                     GRYSGRPNIGMFLKGHAGDMIRVNRQGRDSEHIEHPAVTMGLAIQPEVLDSIGRMEGAE
                     GRGLLARFLYSRPESLVGRRNLSPALLSEETATTYAKRLGGLAMALADWTDPALLTLTP
                     EADAVMLAYQKVTESRLGKGGSLYPIIKWASKRDGAVARIAGLLHLATHPDNGWTLPIE
                     ASTMAAATELGDYFTAHAVDVFDAMAADPAQEAAHHVLTHLRETRPADFTKRQLFRGLS
                     RADFPAMADLDPALVLLEEHGWVRQQPLPPRTGRGRPPSPRYQAHPRLTTG"
ORIGIN
        1 gtgggggacg gggccggctg ccgccgctcc gagccgagcg cggagttcgg gcgcgttgtg
       61 gagcgtgacc tcgccgatcg cgtacacctc gcccacccgg tacggccccg cagcggcgcc
      121 gggcccgtcg agcagaccga gcgcgtgacg ccctgcccgc gtcggtacgg gacggccgcc
      181 catggccgcc acctgccccg ccggatcatc ggcggtcaca gacgcacacc agcgggacat
      241 ctcacgcccc ctctctcttc tctcgtcatc cgcgacgcac cctcgccggt acggctccca
      301 agccccggac cccggacccc ggaccccgga cctccggctc agccgaagtc gtcgtcggag
      361 tcgccggatc cgtcgcccca gtccccgtag ccggcgtcac ccccgccgcc gtcaccgcct
      421 ccgcccgacg aactggcctc ggcctgtcgg cgcagttcct cctcctcttc cggggagagg
      481 aaagcgggcg gcaaggtcag cccgccgatg acggcaccgg cggtgaccgc gcccaggacc
      541 gtgcccagcc ggccgccgaa cgacgtccga ttcaccgtca gcaccccgtc gctccacagc
      601 gtccggccgt agccggcctc cctgccgtag atcggccgac gcccgttggt gtggacccgc
      661 ttgacgatcc gcccgcccag cagctcgtcg gtgcccgaac caccgcgctc gtcacgccac
      721 tgcacgaccc ggcccccgcc gccgaccgcg ctgcgccact cctgaccgcc gtccgagtag
      781 cgccggtgga ccgtccggtc ggcgagcagt tcgtcggtgt aggtgatctc ccgcctctgc
      841 ggctgcggca ctgcggttcc tctcatgcgg tgggccagct caggaaaccc gcccggcgca
      901 cctggcggag ttcggtcaac tgcgagcgtg gcgtgcgtac ttcccgtacg agacggtgca
      961 ccgtacggat cagtgacgcc gggttcacgg cggcgacctc cacgaatctg ccgcgccgca
     1021 gccagtcgcg ctcccagcga ccgagctcga acgcgacccc ccgaccagga ccccggccgg
     1081 caccgggacc cggaccgagg ccggatcccg cggtggggaa agcggccgga acggcggcgt
     1141 acgccgggcc ccggccgtgc accagatgca gtgcccccgc ctgcctgggc cgcagtccca
     1201 gcgggacgac ccgcactccc tccggtacgt cgaccgcccc ggcgaaccgc gcggggaagg
     1261 tgagcccacg cgcactcgcg tcgtgcagga gatagaccgt cgcccgctcg gccagcgcga
     1321 gcatcctcag catcccttcg gcgaggggca gttcggatgc gccgtacacc gggcacgccg
     1381 actccatcgg caccccgttg gcccgcagca tggcggcgat gtcgtcggac tcgcagacca
     1441 gcagcctcgg caggccgtag tcgaacaggt cgggctccgg agtgtgccgt ccggccgcct
     1501 gccggggctt cggcacgacc ggcggcagca gaccgcccac cgagccggga ccgtggcgac
     1561 gcagcgcggc caggtacgcc tcgtacgtca gcgcgggggc cgaggtgaac tgcgcgcgcc
     1621 ggggtgcccg gtgccacggc atcagcaccc ggcacacctc gtaatacaac tgccgctcgg
     1681 tgaagcgcag ttgaccgggc tctgcggcct tctcggcggc cgtccgcagc acgcggtcga
     1741 ggatcgcgtc cccgacgggc ctcgtccgcc ccgcctgccc cgaatccctc atgacgccgt
     1801 cggccaggtg aggaagccga cctgctgtgc gcggccccgg tcggggtcgg ccagcccctc
     1861 cgcccggtcc accgcccgtg cgaccacggc cagcagcttc gccggcggta cggccgcgag
     1921 cggggaccac cagccccggg tcagccagtc ggcctccgcc gcggtcagcg ccgacgacga
     1981 cgtacggatg gcgtccaggt ccccagggtc cagcggcttc cgcagccgta cggcgttgtc
     2041 cttgtccatc accgtgcgcg gcagcatccc cgcgaccacc acccggccac cgagcgcggc
     2101 cctggccgct gaggcgaagg cgagccccgc cggactggcg tcgtgcagga ctatccccac
     2161 aacaccccct tctccgggcg gggtcgggcc ggtggatatg ttcccgagct ggtccagtga
     2221 ctgcgccagc gcgagcgagt gcgtcttgtg cgcaccgttc agcgagaggc aggtcagcac
     2281 tgcgcggtcc ggacagagca gtgccagcct cgggcccggc cctccggagg cggggaccac
     2341 cgggtaccgg gcgctgccct cctgcctcag tccggccggc gggcctccgt aaacggctgc
     2401 ccagcggtcg atgatcgcgg tccggaacat gtcgagcggc atcggtacct gcaccgtgcc
     2461 ggtccgcttc gcgctccggg aaccgcccgc cgtcagcagg agtgccagcg ccaggaccac
     2521 cacgcccacc acgacggcgg ggcgcaccac gtccggatcg aagtcggagg cgtcgctgac
     2581 caccagcagg atgaaggacg tcaggacgac aaggaagctc gcgatgcatc cgtacgccac
     2641 agccccggtg ggtgtgtggt tgcgcgcggc ggcgtaccag agctgagtgg gcgtgtagcg
     2701 cagcccttcg ccgttgccga gcttctcgat gagcttgcgc atccggatgt cgtgcagacg
     2761 gagcgcgttg cccttcggtt cgagcgcgaa ggtgcgcttg cagaccgagc aggtcgtgcc
     2821 ccctcgctcc ctgtagcgaa ggctcttctc acagtgcggg cagatcacgg tggccccctc
     2881 caactgcccc gacaagcgcg tggtttcgtt atgtcgaccg gacagatcct agacgacgga
     2941 gcttgattca catggacaat tcccgtacga gaatgaaaca cgaggcgaac gcggagaacg
     3001 aggttcacga cgtcgccgaa ttcacggacg cggcgagaaa tgtcgtcacg cccgtcctgc
     3061 aactccccga ggacatcgcc ctggccgtgg tgaacgcctt caccaagatc gtgcgggacg
     3121 cgaagagaag cgaatcggcg acgatgccgg acagcgacgg gataacgcgt ttccagactt
     3181 tcgaggaggg cgacgtctat atgctcgaag cacccttcga cgacttcttc gccgatcgct
     3241 atctgatgga tttctacaat gtggaggagc gcggcgtctg ttcgcgtatg catatgcaca
     3301 ccgggctgcg attcgtgcgg atgatgacgg gcccggcgac gcggatccgg gtgagcagtc
     3361 tctcgccgtt cgagaccaca ggtgtcaccg gagtaactcc tttcacgttg cattccttcg
     3421 aggacacgct gcccgacacc ccgccggggg tggtgcggac gcggtacaac ctggtcgtgc
     3481 ccccctgctc cttcgtggac atgcagatcc cccgcggggt gagccaccag ttcaacgccg
     3541 tgggcgagca cgccgtcatc gattccgtcc accccgagga gtccgtggag acattccgcg
     3601 aaaagatttc cgggttcaag atgatggcgc agacggtatt cctcgcggac gaactccccg
     3661 cgtcggacac ctgcgcgaat cttcccgcct gagcgagcgg cggctatccg tcgttctcgg
     3721 aggtcgtgga gagccggcgc agccactccg tcatcagcgc cacctccgcg gtgctgagcc
     3781 ccgactccgc cgaccgcccc agcaggacat tcaactgggc cgccgccgca ggcagttgag
     3841 tcctggccgc ggcccgcgcc gggctgtccg ccatcacttc cggggtgaag acggtggcgt
     3901 ggacggagtc acggacccgc cgggaggtgt ctctgtcggt gaaggtcgtg ggacgggcga
     3961 cgagcatcag cgccaccccg acattggccg acatgacgac ctgcgccgcc gcctccggcg
     4021 ccagccgcaa cttgccgtcc gccgccgccc gccgcaggtc cctggtgagg atctcgtggg
     4081 actccagcgc cgcagcggga ggtgtacgca tcgcggggga gtacatcagc cggtacagat
     4141 tcgggttgtc cagcgcgaac tccacgtggc tgtcccagcc cttgcgcaga tcctctatcg
     4201 gatcgtcctc cggagcacgc tgccgcttgg tctccagata tctgtcgaag ccgtagtcca
     4261 cgacggcgga cagcagccct tccttgtccc cgaagtaccg gtagagcgcc ggggcaccca
     4321 cctgcgcggc gtcgcacacg gcccgggtgg agacgtcgcc gttgggcgac tcggcgacca
     4381 gccgcgccgc gacttccagg atccgcgctc gtgtgctcat cgcggacgac cgtatcaagg
     4441 tccccgtaac gctgttacgc atgcggagcg ctcctgttgg ctcgctgggt gccgaacccg
     4501 ttcgtgtcgt ggacggtgcg cccggcgcgg gcgagagcgg tggtttccgc ggtgtcactc
     4561 atgacaggac tcctcgttcg atcgcaggac gtcgcggacc tggtcactga cgcggatgcc
     4621 atggatctac ggacgcgcgg cgcgcggttc caggcgcgcg gttccaggcg cgcggttcca
     4681 ggcgcgcggt tccaggcgcg cggttccaag catgcggctc caggcgtgcg acgtgcgacg
     4741 tcagatgatg ccgccattgg cgcgcagcac ctggccgttg acccagcggg ccggtccggc
     4801 gaggaaggac acgacctcgg ctatgtcctc cgggcgcccg agccgctcca aaggcggctg
     4861 cgcggccagc ttcgagacgg tctcctcgtc cttgccgtcc aggaacagag cggtggcggt
     4921 cggtccgggc gcgaccgcgt tgacggtgat gtcgcggccg cgcagctccc tcgccaggat
     4981 cagggtcatc gcctcgacgg cgcccttgct ggccgcgtac gccgtgtatc ccgggaagga
     5041 caggcccagc accgagctgg agaagttgat gatcgccccg ccgctccgca gccggcgcgc
     5101 ggcctgctgg tcgaccacga acgtgccgcg gatgttggtg cggtgcatac ggtccagcgc
     5161 gtccagctcc gtatcgacca gcggcgtgac cgacatgacg cccgccgcgt gcacgaggac
     5221 gtcgacgccg ccgtaagcct cctccgccgc gtcgaagagc gccgaaaccg cgacctcgtc
     5281 ggccacgtcg gcgcggaagg ccatggccgt cccgcccgct ccggtgatcg cggccaccgc
     5341 cgcctccgcc tcggtccgat tccccgcgta gttgacgacg acggcatgtc cgtccgccgc
     5401 caggcgctcc gcgctctccc ggccgatccc gcgggaccct ccggtgacga tcaccacgcg
     5461 acgcgctgtg ctcggctgct cagtcatgac gttgttccct ccacccatgg ggatctcagc
     5521 cgggaccacg atgtgaactc cccgacgaca tcaacgctaa catgttcgag ttagcgacgc
     5581 taccctgatc cgtagcatcg ctacgtctcg cgactccggt gcgggcccgg ggcccggctc
     5641 cggcgtcggg cccgacgccg atcgcggagc cgacggagcc gacggagtga ttcaaagaaa
     5701 gttcccgcga gctgtagaga acccgtcatc ggctccgacg tcccctgtga gagtcgccca
     5761 caaggggtga ccacgcagca gccggcagac agtcggcagc tgagggcaga aggagtacgt
     5821 catgaagtat ctggtgatgg tccagggttc gcaggccgac tacgacgcga tgaacggcaa
     5881 ggcgtccgag cacagcgcgg cctggagcga gaaggacctg caagcgatgt tcgccttcat
     5941 gggcgagatc aacaacgacc tcgccgaatc cggcgagctg gtggacgcga acggtctggc
     6001 cgcgccctcc cagacccgtc tcgtcggcgc tgacaaggac gggaagccgg tgatcacgga
     6061 cggcccgtac ggcgagacga aggaactcct cgccggatac tgggtgctcg actgcgccgg
     6121 cctggagcgg gtcaccgaga tcgccgcccg cgtcgcgacg tgcccccagc ccgagggcgt
     6181 cccggtgtac ccggtggtca tccggcccat cccggacggt ccgggcgtcg atggctgaga
     6241 caccgtgcgc gctccggcac gacggggtgt aatacgcggt gtgaaagacg gtacgaagaa
     6301 cggtccgggc ccaccggccc gccccgccac gaccgaggac ctgctgcgcc tgcacgcgcc
     6361 gcaggtcctc ggcgcgctcg tccgccggta cggccacttc gacctcgccg aggacgccgt
     6421 acaggaggcc ttcatcgccg ccagccagca gtggccggcc gccgggccgc ccgacaaccc
     6481 ccgcggctgg ctgatcaaga ccgcctcccg ccggctcgtg gaccagctcc gcagcgagga
     6541 ggcgcggcgc agacgcgagg agaacgcagc cgcgctggcc cccagggaca ccttcaccgc
     6601 gccaccgccc ggcgagagcc gcgccccctc ggaggacgac accctcacgc tcctcttcct
     6661 ctgctgccat cccgaactgc ccgccgccgg ccgtaccgca ctcaccctgc gcgccgtcgg
     6721 tggtctgacc accgccgaga tcgcccgcgc gcacctggtg cccgaggcga cgatggcgca
     6781 gcgcatcagc agggcgaagc agaagatcaa gggcgtgccc ttccggcagc cgggtccgga
     6841 ggaccgcgac cgcaggctcg ccaccgtgct ccaggtgctc tatctgatct tcaacgaggg
     6901 tcatacggcg acctccggca gcgagttgca ccgcgccgac ctcgcgcacg aggcgatccg
     6961 gctgacccgc gcggtacggc ggctgctgcc ggcggacggc gcggtgaccg gtctgctcgc
     7021 gctgatgctg ctcacggagg cgcggagcgc ggcacgtacg ggaccgcacg gcgaactcgt
     7081 cccgctggac gagcaggacc gcacccgctg ggaccgcgcc gcgatcgccg agggtacggc
     7141 gctggtcgag gagtcactgt cccaaggacc ggccgggccc taccagttgc aggcggcgat
     7201 cgccgcgctg cacgacgagg cggcgagcgc cgaggagacc gactggctcc agatcgtggc
     7261 cctgtacgac gagttggtac gccgggcccc cgggccggag ccgatggccg agctgagcag
     7321 ggcggtggcc gtcgcgatgg cgcacggccc ggaggccggg ctcgcggaac tcaagggact
     7381 tgagaaggag ttgtcgggaa accaccggct cgacgcggtg cgggcgcatc tgctggagaa
     7441 ggccggcgat acggaaggtg ccctggccgc ctaccgggcg gcggccaacc gcacgctcag
     7501 cgtgcccgag agccgctacc tgatgatgcg ggcggcacgc ctgcgcgcct gacgccgaat
     7561 cagcgacgca ctgattcagc gagccggcgg ctgggcgggt cagccggtct accgctcaac
     7621 cgctcaaccg ctcaggctgc cgaccgtccc cagttgcttc cactcgccct tctcacggac
     7681 atcgatccac accggccggc tcaccgcctg gtggtccttg aagcggtacc ggccgagcac
     7741 tccctcgacg tcgacgcccc ccacggcctc ccggagcgag gcccgcgcca cccctggatc
     7801 ggtgtccgtc gtcccgtccg gctccggcag ggccccgtcg tccatcacct tcccgatccc
     7861 ggcggcgagt acgagcgcgc cgtcgtacag ctcggccccg ccccgcgcct ggaacatctt
     7921 ccgcagcgcg gcaggactcg aacagacctt cgggaacggt ccgcagtcgg ccttcggctg
     7981 ccgctcgtcg tggaaggacc ggaagcgcag cgtgccgtcc ggcaccaact tgtcttccct
     8041 gtcggtgtat tcgtggtcct catcggtgtc gcaggacgcc tcgtagtcct cctgcaccac
     8101 catcaactgc ccggacttct ccagggcgtc gacccagccc tcgcgttgcc gggcgttggg
     8161 gagcgtgacg gtgtccggcc gctgcttgcc gacgtcgcgg gcgacgtcct cctcgtccat
     8221 gtcctcgggg tagtccaccg cctcgacggc gtcgataccg gcttcgcgca gcccttgccc
     8281 gagcgtgcgg cggtgcggat cgtcctccgc gatgatgtcg tcgtcccagt tgaagtcgga
     8341 accgacgatc accttctgca cgccgtacgc gcccgtcaga tagcgcccct cctgcctgcc
     8401 catgtcgaac ttcgacggca tcgtgccgaa cgcgaagtcc gggcccgagc tcccgttgca
     8461 ggtgtcgacg gcggccatgt cccggtcgaa ctccgtctcg acgccgtcga cgctgttgac
     8521 atcaccgacc agcgcgatca tccccgggta cttcttcagc atctcggtgg ccggggtctc
     8581 ccggtcgtcc ttcaccggga cgacgcgcac cggcagcttc ccgcccgacg cgcgcgccgc
     8641 gtccttgaac gcggcctcga cgatcgccgc gcgctcctcc ccgtgccgct cgtcgaggga
     8701 ccagtcgtac gggacgccga cgacgtactg gtccgcaacc gccgcactgg gtccgtcggc
     8761 cggaacggac ccaccggacg aagacgacga ggacgacgac gaggagatca cgagcccggt
     8821 cggtataccg agcacgacga gcgccacggc ggccgcgaca agggcgttgc gtggacggcg
     8881 ccgtacgggt gccgggggcg gggtggagac cttcgcgacg aagtgcgggc ggggggcggc
     8941 cggagcgggg gccgcgaccg gagcgggcgt ggccggacgt tcgtcctccg gctcgggcgc
     9001 agccgcgacc acggccaccg ccgcggcctc cggctcaccg ccggactcct cccgcgcccc
     9061 ctccagcgac gaccgcgccg actccagcgc ttcccgcgcc gcacgcgcgt ccgacggccg
     9121 gtcgtcaggg tccttggcca tcagcgagag gatcaaccgg tccatttcgg gaccgagttc
     9181 ggcccgcgca cggctcggcc gcaacggctc gtcgttcagg tggttgtaca tgatcccggc
     9241 ggcgtgaccg acgaacggcg gtcgcccgac gaggagttcg tagaggacgc agcccagcgc
     9301 atagagatcc gtgcgcccgt cgccgttccg ctgctgaaag cgttcgggcg ccatgtacag
     9361 cacgctgccg aacggcgcct gtccggtccg cgtgagctgc ggatcactgg accgggcctc
     9421 ggtgtacttg gcgatgccga agtccacgac cttggcgaca ccctcgccgg tgaccatgat
     9481 gttggccggc ttgatgtcgc ggtgcacgat gccggccgcg tgcgcgacct ccagcccccg
     9541 gcacacgtcg atggcccagc ccagcgcgtc cgccacggtc gcgcgcccgc tctcggcgag
     9601 gacgtcgtgc agcgtacggc cgtccaccag cgccatcacc aggtacgggc tgtcgccgtc
     9661 cgtaccgtga tcgtgtacgg cgacgatgtg cgggctgtcc agcgaggcca cggcccgcgc
     9721 ctcccgccgg aaccgcgcca actgctcccg ccgctccccg tcgcctccgg gcgcgagcag
     9781 cagcttcacg gcgacctccc gccccagctc ccggtcccgc gcccgccaga cctcccccat
     9841 cccgccggcc ccgagcaact cccccaactc ataacgcccg ctcagcaacc gcccccgcac
     9901 gatgccactc cccctccaca gacctggggg cgagggtatc tcccggcccg gaccgagacc
     9961 cggggcgggc cgccgtctca gcgggaggag taggaggagg tcacggtgtc agcgcctttg
    10021 cctccgtcgc agatgccggg gacgggagct ggattctcgt cgccgatgtg cccgggcccc
    10081 tcggtgtcgg ggggagccag cgggtgatgc ccgcgcggtc gtggagcagg tcctcctcct
    10141 tgtagcggtg gcagccgtcg tgccagacga ggatgccgga cagccagttc tccagctcct
    10201 tcacgtaacc gtcgaggacc gcgcgcacct cggcgtcgag ggcgaagtcg tcgtacagga
    10261 cggggagttc gttggccgcg acatgctgga actggcgcat gcggcccttc atcaggtcgt
    10321 ggacgatggc gacacccgtc gggtagtcgc agttgaagaa ggactgcacg acgagcacgc
    10381 cgttgtggac ctcgccctcg aactcgatct ccttctggta cgagaagagg tcgttcatca
    10441 ggcaggcgta gtcctgggcc gcgttctcca gggacttcat cgggccgctg cggtagatct
    10501 ccggcggcac ggcgtcgctg tggccgatgc ggcacaggct catcgtcatg ttggagccga
    10561 acgtcgcgcg gcgcatctcg atgtagtcga cggggtccgg gatgcggttc tggatctggt
    10621 tggtcagctc ccagacccag ctcgccgtca tgtcctcgac ggaagcgcgg aaggcccggc
    10681 gggagtccac gtccatcggg cccgccgtcc gcagccacag gtcggccagc ccgcgctcca
    10741 gcgcgctgag cggtggcggg gtgtcgagcg tctcgatcgg catgaacagc gacagccgtt
    10801 cgttgcagac cttcgccgcc gccagattgc gggtgttgcc gtagacgacg gggaagaagt
    10861 cgtcgccgta cgtcccccag gccagccagt ccgacgtcag gtcgagccct tcgggggtcg
    10921 cgtcggggtg gatgccggcc gcgcacagcg ggacgtcgat acgccggatc cggtcctcgt
    10981 cccagacgtc cgagccgggg ataccgggct ggccctccag gatgcccatc cggcgcgccc
    11041 actccacgct gtgctcgcgc gctgcctcca ggtgcgggct gagcctcgcc tcgaacggca
    11101 tctcgaacgc gggcaggatc gagggcccca cccgctggta cgggacatgg ctgtggctgc
    11161 gcgccctggc gggggagccg ttggtgaggc tcttgagata gtccgacgcc gccgtcccgc
    11221 gcccgaccgg cgtcagcgag aacagcgggc ccgccgtctc ccccgccgcc gcgcccttgc
    11281 ccgcctccgc gccgttcatg taccggctgg agcgcatgtg ccactcgtgg ccgccggact
    11341 gccagtcctg gaggcccttc acatacgcca gggtcccggc cgccgcgacg ggatcgacgc
    11401 ccttctccac gaagagcggg cccagctccg tcagcgccgt gttctcgaac tggtggagac
    11461 gggaggtcag caggtcgttg accgcgtccg ccgcctcctg tgtcgtgcat ttcaggaacg
    11521 tctccaggac gagcacgccg ttgctcagct cgccctcctc ctcgatctcc cgctggtacg
    11581 agaagaggtc gttccgcaga tggaccccgt cggagaacgt gtcgcgcagg acccgcatcg
    11641 gacgggagtc ggcgatctcg gccggcacct ccgcacccgc cgcgtactcg atgagcccgg
    11701 ccgaccacgg cgccccgccc accttgcggc gcatctcgat gtactcgacg ggattcgaga
    11761 tccgctcggc gttgatgttg gcgagctccc agagggattc gttgagcaga ttctccgtgc
    11821 tctcggcgaa ccgggcccgc cagtccaggg acatcgaggg gaccgtgcgc ctccagaggt
    11881 cggcgagtcc cgcctcgacc ggattcgtcg gctcgggaaa cccgtcggcg agatccatcg
    11941 gcatgaacgc cgggagccgg tccagatacg ccttgccgcc ctcgcggtcc tgtgtccgct
    12001 tgaagatctc caggaagtgg tcgtcgaaga agaagaccca cacataccag tcggtgacca
    12061 gcgacaactg cggccccgtg cagtcgggat gggtgtaggc gcacaggagc gcgtagtcgt
    12121 gcgcgtcgag atcgctctgc tcccagatgc cggagccctc cagcatcccc atgtccctgg
    12181 cccacctccg ggagtgctcc ctggcctcct ccagacgggg attgatacgc gccggataag
    12241 gcatgtagaa atccggcagt tcgaagggtc gtgtcactgg tgcgcggcct ttcccgaggt
    12301 ttccggagga ttccggcaac tgtccgtgtc cagctctacc cctcgtcacg taccgccatc
    12361 cgcgccataa aacagtcata tgaacacacc attagggcgt ggcctccgtg aaatcaaccg
    12421 cctcccggtc caccatctgc ccatgagcac cacgattcgg atcgcacagc agcccgaggc
    12481 cgacgaactc ctcggccgca gcccactggc cgcgctggtc ggcatgctgc tggaccagca
    12541 ggtgcccatg gaatgggcct tctcggggcc gtacgccatc gccgtacgca tggggggtga
    12601 cgatctggac gcacgcgcga tcgcgacgta cgaccccgcg gcgttcgccg cgctgctctc
    12661 ggagaagccc gccgtgcacc gctacccggg gtccatggcc aagcgcgtgc agcagctctg
    12721 ccagttcctg gtcgcgcact acgacggcga cgccgccgcg gtgtggaaag acgccgccac
    12781 cggcgcccag ctgttcaagc ggctgaccga gctccccggc tacggcaagc agaagtcgca
    12841 gatcttcctg gccctgctcg gcaagcagta cggcgtacgg cccgagggat ggcgcgaggc
    12901 ggcaggcgcg tacggcgacg agggctcgta ccgctcggcg gcggacatca cggggcccga
    12961 gaccctggcc aaggtccgcg cgcacaagca ggaggccaag cgtgccgcca aggcggcgaa
    13021 gacggccatg agccccccga gccgcgcgaa gggctgagtg gacgcgagcg cgagtgcagg
    13081 acttgtggca catctgttcc cctggggcac ccctggtcgc taactttcct tagcttcact
    13141 ccgcaccgct cgcattcgtt cgcatcggaa ggacccctgt gaacgcaacg tcccgcagac
    13201 tcatggcagt cgcagccgcc accgcgctcg cggccccgct tctgctgtcc gcatcctccg
    13261 cctccgccca caacaggccc gacccggcga aggacgcgtc aaagctttcc aagaagctcg
    13321 tcaaggaggc gtccggcaag gacgcgtaca agcacctgaa gaagttccag gacatcgccg
    13381 actccgccgg cggccaccgc gcggcgggct cgctcggcca tgacgcctcc gccgcgtacg
    13441 tgtacagcct cctgaagaag gccggctacg acgtctcgta cgacagcttc gagttcacgt
    13501 acatcgagac gcaggccgag acgctgaagg tcaccgcgcc gacgccgcgc gactcccaga
    13561 tcacggccat gtcgtacacg aagtcgacgc ccgagggcgg tatcgaggcc ggcctcgccg
    13621 tcgtgccggt cgacgcgacc accggctgcg aggccaccga ctacgccgcc ggagccttca
    13681 ccggcaagat cgcgctcatc cagcgcggcg gctgcgactt cgccacgaag cagcagatgg
    13741 cggccggcgc gggagcggtc gccgcgatcg tctcgaacaa caccgagggc gccctcagcg
    13801 gcaccctggg cgacccggcc gcggccagga tccccaccgg cggcatcacg caggccgagg
    13861 gcgcgaagct cgccgccgag gccgccgcgg gccccgtgac ggtctccctg gacatccgtc
    13921 agctccagga ggagcgcacc acccgcaacg tcatcgccga gaccaagggc ggcgacacgg
    13981 ccaacacggt gatgctcggc tcccacctgg actccgtcac cgagggcgcg ggcatcaacg
    14041 acaacgcgtc cggctccgcc ggtctgctcg aagtcgccct ggacctcgcc aagtcccgcg
    14101 agaagaccgc caacaaggtc cgcttcgcct ggtggtcggc cgaggagctg gggctgctcg
    14161 gcgccgagga ctacgtcaag ggcctcagcc ccgagcaggc cgaacagatc aagctctatc
    14221 tgaacttcga catgatcgcc tcgcccaact tcggccagtt cgtctacgac ggcgacgact
    14281 cggacgccgt cggcgagggc cccgggccgg agggctcggc gcagttggag aagggcatca
    14341 ccgacttcct cgacagcaag gaccacccac acgagggcac cgacttcacc ggccgctccg
    14401 actacgggcc gttcatcgag gtcggcatcc cctccggggg gaccttcacc ggcgccgagg
    14461 gcatcaagac cgaggcgcag gcggcgaagt tcggcggcga ggccggggtc gcgtacgacc
    14521 cctgctacca cgcggcctgc gacgacctgg acaacatcaa caaggaggcg ttcgacgtca
    14581 acatcgacgt catcgccgac gccgtgggcc agtacgccca cgacctgagc ccgctcaccg
    14641 cgaaggccaa ggcccaggcc acggccaaga cggagcgcac cacgggcggc gacaccggcg
    14701 tcggcgcgtc gaacgcgcac gaccacgagc acgggcacga gaccaggtcc tgacaccctg
    14761 gcggtctgat tcacccacag cctgacaacc actcacggcg ggtaccgagg gagcgagttc
    14821 cctcggtgcc cgccgttcgc gctcggcctc tccggaaggc gatacgggtc gcgacaaggg
    14881 cgtcgacgtc accggacggg acggttccac tcatacgcca ctcccacttt gacccgtatg
    14941 gatctctttg caccaccgcg ccatggctgc gcccggaggc gctcgcccgg taggctttcc
    15001 gtgtgatctt caagcgcatc ggaaatgggc gaccgtaccc cgaccatggc cgggaaagta
    15061 cccggcagtg ggcggatgtc gcgccgcgcc cggtccgcct cgaccagctc gtcaccacca
    15121 aagggcaact ggatctggag acgctgctcg ccgaggactc gaccttctac ggagacctct
    15181 tcgcgcatgt cgtcaaatgg cagggcgacc tctatctgga ggacggcctc caccgcgcgg
    15241 tccgcgccgc tctccagcag cggcaggtgc tgcacgcgcg cgtgctcgaa ctggacctgg
    15301 gctgaaccga ccggccaccg gtcgccaacg ccccgcccgc cgactcgtcg gccgggctga
    15361 cgcgccgacg ggcactcaac cgactcggga ctgagccttt cgggggcttt ccgacgccca
    15421 gaggcccgac ctgttgatca tttagtagga atcactaccg gcgagcacta cgctgcggcc
    15481 atgagcatgc tcaccccccc tggcatgggc ggcaaatatc gcatcacggg tgccaagtac
    15541 ccccgcatgc gtcgcccccg gaaccgccgc aggatcgtgc tcgcggccat cgccacagtc
    15601 gtcgccctcg gcctcgccgg ctgggggacc gtacagctca tcgacgtgtt cacggcggac
    15661 gacgggtcgg cgaagaagac gacgacggcc tccggccgcc agcccgactg cagaccgtcc
    15721 ccgtccgcgg cgcccgtcaa gacgctgccc aagccggccc agatcacggt caacatctac
    15781 aacgcgacgc cgcgcgccgg actcgccaag accaccgccg acgagctcaa gaagcgcggc
    15841 ttcgtcatcg gcaaggtggg caacgcaccg gcggccttcg acaagaagat ccccggcacc
    15901 gggatactgc tgggcgcccc ggccgcggcc gacagctcct tcacggtgct cggcgctcag
    15961 ctgaagggcg cgaagcccca gcacgacgag cggaagacga aggacgtcga cctgctgctc
    16021 ggcacggcct tcaagagcct gagcgtgcag aaggacgccg agcgggccct ggccgtcctc
    16081 accaggccct caccgggcgg cacctgcgac cacaagggct agtgaggctt ccctccggcc
    16141 cgggtcccca ggtcctgtcc cgccgggaca ggacctgggg catgtcctag tcgaccgtcc
    16201 cgtacatgcg gtcgcccgcg tcgccgagcc ccggcacgat gtatccgcgg tcgttcagcc
    16261 gttcgtcgac cgccgccgtg acgacggtca ccggcgtgcc cgccagctcg cgctccatca
    16321 cctcgacgcc ctcgggcgcc gcgagcagca cgacggccgt cacgtcgtcg gcgccgcgcc
    16381 cgatgagctc acggatcgcc gcgaccagcg tgccgccggt ggccagcatc gggtccagga
    16441 cgtacacctg gcggcccgag aggtcctcgg gcatccgggt cgcgtacgtc gacgcctgaa
    16501 gcgtctcctc gttacggatc atcccgagga aaccgacctc ggcggtcggg agcagccgca
    16561 ccatgccgtc gagcatgccg agaccggccc ggaggatcgg caccacgagc ggccgcgggt
    16621 aggagagctt cacacccgtg gtcggcttca ccggagtctc gatgtcgacc tgttcggtgc
    16681 gcacgtccct ggtggcctcg tacgcgagca gggtgaccag ctcgtcggcg aggcgtcgga
    16741 aggtagggga gtcggtgcgc ttgtcgcgca gcgtggtgag tttgtgcgcg accaacgggt
    16801 ggtcgacgac gtgaatccgc atggctccac agtaaccgcg gcccggccgg agccccccgc
    16861 tggcatcaat tccctgtcgg cagggaaggt ggatgggaca cgcacacagg ggacacagcc
    16921 aaccgagtcg tggggtggtg aggcggcgat gcgggaccgg cagcggcgtg aaccgcggga
    16981 gcggggcggc ggggacgggg cggtcgacgc cggaccggac ggctcgcgcc cgcgcccgta
    17041 cgcggacgcc gcgcccgccc cggggtccca ctccacagct gacgccacac ccggccccgc
    17101 gcccgattcc gtgcccgatc ccccaccggt tcccaccgcc gaactcgact ccgacgagag
    17161 cgccgcggcc cgtcggcgcc ggcgcgctca gttcctgcgg gagttgaacg aggccaaggc
    17221 gctgcgcgag cgggtgaaac ctcgccaggc ccgcgcggcc cggatgcgcc agcagatgcg
    17281 gatgcggacc ttccgctggt agtcgcgcgc cggccacccg gcggccctcc ggccgccgtg
    17341 ggacggccac ttgggcaccg gcggaccccc gccccacggg cctctgggcc gccggtccag
    17401 gcatgcgtcc ggaccggtcc aaaaaaatgc ctgcacgacg caacggcgga agacctctcg
    17461 caatcgcccg ctttctgcca cgattccgag tagtgggcgg ggcagagcgc agcgcaccgc
    17521 cgaattcgtc acctctgacc agtgggagag tcacggtgta cttcgccgca ctgctcgcgc
    17581 gcaccgaaga cggatgggca gcgagcgaca cagagctcga cgacgtggag accttgtcgg
    17641 atctgaccga cctggcccgc gaagcctcgg tggacgagga cacggtgctc gtcttcatcg
    17701 agcaggagga cgcctggttc ggcgtgctcc gcgtggaggg cgaggaggat cctcgcatct
    17761 acgtctccga cgcggccatg gccgcacgct cctcgtacgg ggagatcctc acggacgaat
    17821 tgctcggcgg ggacgacgac ctcgacgacg ccttggacac gctggacctc gacggtaccg
    17881 aggacggcga gactgaagag caggaggaca cggacgacag ggacgacagc accggcaccg
    17941 ccgtcgcggc cggaccggga acggttcccg cgggtccggc gggcgaccgc gggatcctcg
    18001 cggacctggg cctgtcggag gcggagctgc tggcgctgga gaccgacgcc atgtccgaga
    18061 tcgcggacgc gctcggcgcc tccgaggtgc tggagaccgc acgctagtga ccgagcacga
    18121 cccggtgggc gaaccggcga gcgacccggt ggccgacccg gtccgcgggc cgtggcgggc
    18181 gccgatgcgc ctcgccctgg aagaggccgc acgcgcggcg ccgtccggcg atgtgccggt
    18241 cggtgccgtc gtgctgtccc cggacggctc ggtgctctcc gtcggccaca acgaacgcga
    18301 gatgacgggc gaccccaccg cgcacgcgga ggtcctggcc atccgcaggg cggcggccga
    18361 actcggcgcc tggcggctga ccggctgcac gctcgtggtg accctggagc cgtgcacgat
    18421 gtgcgcgggc gcgctcgtgc agtcacgggt ggcgcgggtg gtgtacgggg cgctcgacga
    18481 gaaggcgggc gcggcgggct cgctctggga cgtcgtacgg gaccggcgcc tcaatcaccg
    18541 cccggaagtc gtccacgggg tgctcgccga ggagtgctcg cggctgctga cggacttctt
    18601 ccgcgaccgc cgcgttatcg atttctgagc aggggccacc ttgggctaag ctctctctcg
    18661 gtagcgtgtc cgagcggccg aaggagctcg cctcgaaagc gagtgtggcg taacccgtca
    18721 ccgtgggttc aaatcccacc gctaccgcag atgagcgaag gggtggacct catgaggtcc
    18781 accccttcgg cattgccagg gtctcagttc gggtctcagt tggtcgtcac gagagcccct
    18841 gaagccccgt cgtcgtcatc gtcggagccg tcgtttcccg actcccagat gaacccgtcg
    18901 acctgtgcgg cgaccccggt tcgtacggtg tcgaccatgt gctgatagcg cgccgccatc
    18961 gcagtggacg accagcccat gagccccatg actgcccgct cgggaacccc cagaatcagg
    19021 agcaccgtgg cggcagtgtg ccgcgcgtcg tgcagccgtc cgtcccgaac cttcgcccgg
    19081 ccaagcaact ccttccagtc gtcgtagtcc gtgcgtggtg aggtaccgcg cccggttgcc
    19141 gtggggaaca accagccctc ttccgtccag tcgccccctg cggcggcacg ctccgtctcc
    19201 tggcggtccc gatgggtgcg gagcagatcc acaagctgtg ggggaaggcc gaccgcccgt
    19261 cggccggcgc gcgacttcgt gtcggctgtc tcggggttcg tccgttggcg ctccgggcag
    19321 tagccgggct tccggccgca ggtgtcgccg cacccgtggg cgtaccgggg tcggcgcctg
    19381 cttcggcgga ccatcaggac cccccgcttc aggtccacgt ccgcccactt gagcccgagc
    19441 gcttcccctt gccgcagtcc gagggagagc gccacggccc acctagccga gttacggccc
    19501 tcgtcagccg ctcggaggag tcggcggatc tcctcaaccg tgaacggctc gacttcgtcg
    19561 tcccggagcc gtggggcctt ggcgagtcgg acggggttct gtccgaggtc gccacgccgc
    19621 accgcttcgt tcagcgcggt ccggaaggtg cggtgtacct gatgagccgt ggcgggggcg
    19681 ctgccgcgct gctgcatgct cgcgtagaac cgctcgatgt gctcgggctt cagtcggtca
    19741 agccggtgag ccccaagacc tgggatcagg tgcttccgta cggcgtagcc gtaccccgcc
    19801 gccgtgttct cgttgacggc gagcggggcg atgctctcga tccagtgcgt aagccaggtg
    19861 gtaaccgtcc aggcccgacc gggcttgcgg gtggtcctgg tctcgcgctg gcgctccaac
    19921 tcgcgtacgg cctctgtgac ttccgctcgg gtcttgcgct tcacgtgccg gcggtccggg
    19981 gtgccgtcgt ctcggatccc gactgtcacg cggccgtgcc acttcccgtc ggcacccagg
    20041 tagatggacg atcggccgtt cggctgccgt gtgcgcttct tcttactctc atcttccatg
    20101 gaactgccct tcaagctgcc tgcgcagcaa cggttcggta ggactgacgg cgacgggtga
    20161 cgtactcggg gatcgcgtcg gcggggatcc ggcggagccc accgagagtg aaggactcca
    20221 gctctccgga cctgatgagc cggtagcaga ccgtccggcc gatgctgaga cggcgggcgg
    20281 cctcttcgac ggtgagcagg acaagggttt ggtcgttgtc ggtgggcgcg gggctcatct
    20341 gggcatgcct cctcggcacg gggcgcgacg ggtgcgataa atgccggatg ggctgtcaga
    20401 aatgacagaa atcggcgatt gggcctctga gctggggttt tggcttcgga tgggggcgtg
    20461 acagaaatcg cggaaaatct gacagaaatc ccgtccggct aggtggcgtc gagtcggacg
    20521 gggcgcgggg ctgggtttct gtcggacttc ttattgtttc tgtcacgcgc tccgaggcga
    20581 ctgtttccgc aggtcagggc tggtttcggg gatttctgtc atttctgtca gcgggtgggg
    20641 ggtttctgtc agccggtggt gaggcggggg tgggcctggt agcgggggga cgggggccgg
    20701 ccgcgtccgg tgcggggtgg gaggggctgt tgccggaccc atccgtgttc ttcgagcagg
    20761 accagggcgg ggtcgaggtc ggccatggcg gggaagtccg cgcgggacag tccccggaac
    20821 aactgccgtt tggtgaagtc ggccggccgc gtctcccgca ggtgcgtgag gacgtggtgg
    20881 gcggcttcct gcgcggggtc cgctgccatg gcgtcgaaca cgtccacggc gtgggcggtg
    20941 aagtagtcac ccagctctgt cgcggcggcc atcgtggacg cctcgatggg cagcgtccat
    21001 ccgttgtccg ggtgcgtggc caggtgcagc agtcccgcga tccgggcgac ggcgccgtcg
    21061 cgcttggacg cccatttgat gatcgggtag aggctcccgc ccttgccgag gcgggactcg
    21121 gtgaccttct ggtaggcgag catcaccgcg tccgcctccg gagtgagcgt gaggagtgcg
    21181 gggtcggtcc agtccgccag cgccatggcc agaccgccca ggcgtttggc gtaggtggtg
    21241 gcggtttcct cggacaggag tgccgggctg aggttgcggc ggccgacgag ggattcgggc
    21301 cgggagtaca ggaaccgggc gagcagcccg cggccctcgg cgccttccat gcggccgatg
    21361 gagtcgagga cttcgggctg gatggccagg cccatggtga cggcggggtg ttcgatgtgc
    21421 tcgctgtctc ggccctgccg gttgacgcgg atcatgtccc cggcgtgccc tttgaggaac
    21481 atcccgatgt tcgggcgccc ggagtagcgg ccggccatga tgtcgaagat ctcgccctct
    21541 gcggacatga cggagatgcg tccgccctgc ccgtggagga gtgagccgat ggtctccggt
    21601 gtcacgtcgt ccgcgacgag ttgcggcacg gcgggaacgc tcaggctctc cgctgtctgc
    21661 gcgaggctga cggcgtcggc ggtgagttcg tcgcgcttct ccggttcggc ggaggcggct
    21721 ttctgcgctg ccttctccgc ggctgccttg gccagcttcg cggtggtctc ggcctcggcc
    21781 cggacgggcg cggagagttc caccagcatc ttctccaccg ccaggagcgg gtcaaccatg
    21841 agcccgaata cggcgctctt gcggttgccg ggatcgagcg cgacggcggt gtagatgttc
    21901 accggctcgc gccagtgccc ccgcacgcac acggtggccc gtccgccggc ggcggtggcg
    21961 atgaccgcca gggccaggca cccggccagc tccaccgggg tctgtgtctc ctccgcgacc
    22021 tcggacgcca tgttcctcag ccagtcgggg agcgcgtcca cggggaaggc cgggagctcc
    22081 cggcgggcgg acagcggtac gggttcgtcc cacaccgggc cggtgatggt ctcgggatcg
    22141 agcgcgtcga acccttccca cagatcagtg gtgctcatgc ggccaagctc ccttccccgc
    22201 cgtcgagcag cgggcagtgt gcgcggtggt cggtgtggtc ctggacgagt tgctgcacgg
    22261 cggcgcggcc gatcgcg
//
