LOCUS       NZ_CP048397            21068 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. S4.7 chromosome, complete genome.
ACCESSION   NZ_CP048397
VERSION     NZ_CP048397.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S4.7
  ORGANISM  Streptomyces sp. S4.7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.
  TITLE     Viennamycins: new lipopeptides produced by Streptomyces sp. S4.7
            isolated from the rhizosphere of Edelweiss (Leontopodium nivale
            subsp. alpinum)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2020) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.8x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010384365.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 10:27:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,027
            CDSs (total)                      :: 6,939
            Genes (coding)                    :: 6,650
            CDSs (with protein)               :: 6,650
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 289
            CDSs (without protein)            :: 289
            Pseudo Genes (ambiguous residues) :: 0 of 289
            Pseudo Genes (frameshifted)       :: 103 of 289
            Pseudo Genes (incomplete)         :: 223 of 289
            Pseudo Genes (internal stop)      :: 23 of 289
            Pseudo Genes (multiple problems)  :: 52 of 289
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:05:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3068023
            Orig. end                         :: 3089091
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048397.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zotchev Lab, University of
            Vienna, Austria.
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21068
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="9"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21068
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21068
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11068](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11068
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(881..1081)
                     /locus_tag="SSPS47_RS13390"
                     /old_locus_tag="SSPS47_13560"
     CDS             complement(881..1081)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSPS47_RS13390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SSPS47_13560"
                     /product="hypothetical protein"
                     /protein_id="WP_164251303.1"
                     /transl_table=11
                     /translation="MQSSQRRIVRTAPLPAADESVSRPQHSDLFLEAQYTIDLPPLDEE
                     EEADPSTVTTPYRGRPPHVAG"
     gene            complement(1251..2678)
                     /gene="pcaB"
                     /locus_tag="SSPS47_RS13395"
                     /old_locus_tag="SSPS47_13565"
     CDS             complement(1251..2678)
                     /EC_number="5.5.1.2"
                     /GO_function="GO:0047472 - 3-carboxy-cis,cis-muconate
                     cycloisomerase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="pcaB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018384794.1"
                     /locus_tag="SSPS47_RS13395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13565"
                     /product="3-carboxy-cis,cis-muconate cycloisomerase"
                     /protein_id="WP_164251305.1"
                     /transl_table=11
                     /translation="MTNSQPPADTGLFSPVRSGTPAEAATSDTACLQAMLDTEAALARV
                     QARLGTVPESAARAIGEAARAEHFDLYELAVQARGAANPVVPLVRRLTALVAAADADAA
                     HSVHQGSTSQDILDTGLMLVAARTLDLVLADLDRTAAALARLAARHRDTPMAARTLGQH
                     AVPTTFGLKAAGWLQGVLDARDRLRRVRAQGLPVQLGGAAGTMAGYLEYALLHAPDAAD
                     DGGRRCIEELPGALAAELDLTEPLVPWHTVRTPLADLGAALALLTGALGGIAADVQLLS
                     RTETGELAEPAAEGRGTSSAMPHKRNPALSALIRAASYQVPSLVGTLMQVSVHDDERPS
                     GAWHAEWLPLRDCLRLAGGAAHTAAELTEGLTVHEDRMLANLELTGGLVVSERLAALLS
                     VELGRAEAKALLGRASAEAAGSGRHLADVLAETPGLAGRRSADDLRKLSDPAHYTGAAG
                     QLVDRVLGRHRTDRPAD"
     gene            complement(2718..4685)
                     /locus_tag="SSPS47_RS13400"
                     /old_locus_tag="SSPS47_13570"
     CDS             complement(2718..4685)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NpaA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841549.1"
                     /locus_tag="SSPS47_RS13400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13570"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_164251307.1"
                     /sec_met_domain="NpaA (E-value: 1.3e-259, bitscore: 861.5,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDGHLEVCIVGAGPRGLSVLERLCVNARRGLPDGSTLTVHIVDP
                     HRPGAGGVWRTDQSHHLLMNTVASQVTLFTDESVEIDGELAPGPSLYDWAVRTAAAPGE
                     GTGEAYDDQVRAEARDLTPDSYPTRAFYGHYLEWVFRHVVRTAPAHVRVVVHPSRAVRL
                     DGAPDGPQGLCLADGSRVDGLDAVVLAQGHLPVRGGPGERELADFARTHALTYVPPANP
                     ADTDLSAVRPGEAVALRGLGLNFFDHLTLFTLGRGGTYTREDGRLVYGPSGREPRLYAA
                     SRRGIPYHSRGRNQKGAHGRHIPRVLTPEVLERLRTAARLGGGLDFGRDLWPLIAKEVE
                     TVYYTALLARRVGGSEAGRFGDRYLKPAWGSAEESDLLDAYGIGPEAHWDWKHLSLPHA
                     DQGFRSAGDHREWLLDILRRDLAESEAGNVEGPLKSALDVLRDLRNEIRLVVDHGGLTG
                     SSHRDDLERWYTPLNAFLSIGPPAARIEQMIALIEAGVLDVLGPDMRVGTDPDQGVFTV
                     EAPAVPGSATRVTTLVEARLPEPDLRRTTDPLLTDLLATGQCRPYAIADPELGAYETGG
                     LAVTPRPYRLVDTEGRAHPRRFAYGVPTESVHWATAAGVRPGVNSVTLGDSDAISLAVL
                     ALPAGPPRPPVTDHQKSRTT"
     gene            complement(4774..6039)
                     /locus_tag="SSPS47_RS13405"
                     /old_locus_tag="SSPS47_13575"
     CDS             complement(4774..6039)
                     /GO_function="GO:0003979 - UDP-glucose 6-dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019885834.1"
                     /locus_tag="SSPS47_RS13405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13575"
                     /product="nucleotide sugar dehydrogenase"
                     /protein_id="WP_164251309.1"
                     /transl_table=11
                     /translation="MKSKVVVVGQGYVGLPLAVRAAQAGHQVVGYDVDTERVKRLVSGE
                     SYVEDVPDAQLAVLLDRGTYLPTTDPTDLDGFDIAVVTVPTPLRDGAPDLSYIESAAHT
                     LAGRLRPGATVVLESTTYPGTTVELLVPLLEEGSGLVAGQDFHLGYSPERIDPGNPTWR
                     LENTPKVVSGIDSASLTAVQAFYDTITSNTVPVRTTEVAELSKLIENTFRHVNIALVNE
                     MAMYAHELGVDVWEALDAAASKPFGFMRFTPGPGVGGHCLPVDPEYLSWRVRRTLGRSF
                     QFVELANEINGHMPDHVVQRLLLAFNARRRPLAGSRVLLLGLAYKPNTGDARESPALRV
                     AELLLGLGAEVRAADPYVVEAVTVNSRLTRCDFTEEELAAADAVVLLTDHDAFDYELVA
                     RASEFVLDCRHRLETGPTVEVL"
     gene            complement(6152..7339)
                     /locus_tag="SSPS47_RS13410"
                     /old_locus_tag="SSPS47_13580"
     CDS             complement(6152..7339)
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386102.1"
                     /locus_tag="SSPS47_RS13410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13580"
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_164251311.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 9.6e-88,
                     bitscore: 293.5, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTETSAAQAAPIRVAAATATTETVPYAYTRLPDADRELLREVLY
                     EVGTDPEQKFILGRRTAELERRLADRAGVRDVVACASGTGALVLALRAVGVVPGDEVIV
                     PAFGAEPLAATVLGVGAVPVFADVDPVTMVMDPVDAESRVTDRTRAVVPAHTFTTMADM
                     PAIMAWARRRGIAVVEDAAVAQGATLGGRAAGTWGDIGLYSFFPVKPFGMPGEGAVVLS
                     GNIELATLVRRLRNHGQDGVQRFVHHEVGLNSRFDEVLAGYQLARLDRADDMVARRAAI
                     AAHYNSRFAALRGSGLLAPTTGADGQCHYVYAVQTICRDSLAAHLAAHGIGSRVYYPVP
                     LPRLPAFAAYAGEGADGRRPGTELASARHLALPLNLSLTDSQVERTADVVCAFFD"
     gene            complement(7336..8553)
                     /locus_tag="SSPS47_RS13415"
                     /old_locus_tag="SSPS47_13585"
     CDS             complement(7336..8553)
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (41-167). E-value:
                     1.5e-08. Score: 26.1. Matches aSDomain:
                     nrpspksdomains_SSPS47_RS13415_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470383.1"
                     /locus_tag="SSPS47_RS13415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13585"
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_164251313.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 4.2e-113,
                     bitscore: 376.9, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2e-06, bitscore:
                     25.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSKAMPAPASTVPFFTQAESFERLWPRLSAYLDEVCESGTYSNG
                     PKTAELEAALRAYTGARHAIAVGNGTDALVLLLRAAGIGPGDEVIVPAFSFFASASSVA
                     LVGAVPVFADVDPLTYNLDPAALEALVTPRTKAVMPVHLFCQPADMTAVLAVAERHGLL
                     VLEDSAEGIGMRLDGRHTGLIGVGGVLSFFPTKTLGALGDAGMVLTDDDALAGAVQRLR
                     DHGRPALPPPAPAARPAAAPAARAEYARQGELAGTNSKMDELQAAALLTKLTTLDDDIR
                     RRAVLADAYTRRLRGIPGVRGLPAVVERGEPVDPVFYVYLIETDRRDALVSHLAAAGIG
                     TETYYPLPLHLQPCFAHLGHQEGDFPHAEAASHRTVALPLYPELTLAQLGRVCDAVRSF
                     FTGSTS"
     aSDomain        complement(8053..8430)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SSPS47_RS13415_Aminotran_1_2.1"
                     /evalue="1.50E-08"
                     /label="SSPS47_RS13415_Aminotran_1_2.1"
                     /locus_tag="SSPS47_RS13415"
                     /protein_end="167"
                     /protein_start="41"
                     /score="26.1"
                     /tool="antismash"
                     /translation="YSNGPKTAELEAALRAYTGARHAIAVGNGTDALVLLLRAAGIGPG
                     DEVIVPAFSFFASASSVALVGAVPVFADVDPLTYNLDPAALEALVTPRTKAVMPVHLFC
                     QPADMTAVLAVAERHGLLVLED"
     misc_feature    complement(8605..8619)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.53"
                     /tool="antismash"
     misc_feature    complement(8781..8796)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            8860..9819
                     /locus_tag="SSPS47_RS13420"
                     /old_locus_tag="SSPS47_13590"
     CDS             8860..9819
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611473.1"
                     /locus_tag="SSPS47_RS13420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13590"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_239064886.1"
                     /transl_table=11
                     /translation="MTDIVSDKKVILAEPRGFCAGVRRAIEIVEKALEVHGAPVYVRKE
                     IVHNHYVVGVLKRRGAIFVDSEAEVPPGAVCVFSAHGVAPEVRENAKARRLDTIDATCP
                     LVSKVHQEARRYARDGRTLLLVGHADHEEVEGTYGEAPDRTVIVESEESARQLDLPSDT
                     PVAVLTQTTLSMDETAGIVAVLGERFDDLRSPADGDICYASTNRQVAVKEIAARSDLVL
                     VVGSRNSSNSVRMVEVALLEGTAAHLVPDVTELDVSWLDGVTTIGVSAGASAPELLVDQ
                     LLERLDELGYQDVELSVTTKEDIVFQLPSGLSQARPSA"
     gene            10001..11068
                     /locus_tag="SSPS47_RS13425"
                     /old_locus_tag="SSPS47_13595"
     CDS             10001..11068
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385642.1"
                     /locus_tag="SSPS47_RS13425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13595"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_164251315.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.4e-45, bitscore:
                     153.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSPPAPAVGHLGGLAAQSRAAVLDRTEERLDAMLAAEHSRWAA
                     VDARAAVPVDAIGELIRAGGKRLRPAFCAAGFLAAGGELSDSRVVDAAAAIEMLHAFAL
                     IHDDVIDDSDLRRGEPTVHVQHIERHRAQGWQGEARRYGEGIAVLAGDLAFSYAGQLIQ
                     DLPAEARLVWGRLVSEMIIGQHLDVTVAAESLPDPKLARYIANAKSGHYSIHRPLELGA
                     AIAGDTSSAAAFEAYGTALGEAFQLRDDLIDTYGDADAVGKPVGLDAEQHKMTLLVSLA
                     ALRDPRVGELVQAAEWDGAALAEALTSSGVRAEVEHRIDELVVQAHEALSAAPISDEWK
                     RELADMATSVAYRDH"
     gene            11130..12278
                     /locus_tag="SSPS47_RS13430"
                     /old_locus_tag="SSPS47_13600"
     CDS             11130..12278
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013567.4"
                     /locus_tag="SSPS47_RS13430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13600"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_203557836.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 4.3e-06, bitscore:
                     26.1, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNTFIVGGGRAGLGLHWPVLRKLRALPDGSGPWSPDPPVIWDVQ
                     DIREQALAEGLVPADSLAHAAELADPATTVVHLCTPPADRFATLQQLADLGYTRIVVEK
                     PMADDIAGLEAIDMLARVRGLRLRVVSPWLASSLTRELAELTRYGALGELRSMSFTQFK
                     PRWTRTLRSNNHTTAFDVELPHSLGVALRLAGDARITDAALTDMRIGDTVIPDMGGARL
                     TLQHDNGATTEIASDLTSPIRERRVGLRFDTGHVVGHYPISDVDHHASLTVHDDAGGGA
                     AARRLLFDDALTSYIDHAYQEYQAVDAGTDGASGSGGPGNGAPGGVNDMDDYAIARRVV
                     QLLQEARLLAAAQSSRADSAAPVRPPLTGVSPALQGGADHEG"
     gene            12268..13131
                     /locus_tag="SSPS47_RS13435"
                     /old_locus_tag="SSPS47_13605"
     CDS             12268..13131
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385640.1"
                     /locus_tag="SSPS47_RS13435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13605"
                     /product="sugar phosphate isomerase/epimerase family
                     protein"
                     /protein_id="WP_164251317.1"
                     /transl_table=11
                     /translation="MRADIRLSGIGDEAAPGLDRQIEAVRRLGWDSVELRSVDGVPLAE
                     LDGPAFDRVAGSVAEAGLGVSCVDSRIGNWARTVVSPFADDLDELARLADRCERLGTRY
                     VRIMSYPNAGLPDADWEREVLDRVRRLTARAEDAGLVLVHENCAGWAATDPARMLRLLE
                     AADSPALRLLFDVGNGIAYGYEAYDHLAHIAPYVAHVHVKDGTGDTSAQFYSLPGDGDC
                     RVADSLRLLFDQGYSGAVSIEPHINIRPHEGWSDPSGDYVDEFVTYGQRLEKLLRELEP
                     ATDSGI"
     gene            13164..14507
                     /locus_tag="SSPS47_RS13440"
                     /old_locus_tag="SSPS47_13610"
     CDS             13164..14507
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134701.1"
                     /locus_tag="SSPS47_RS13440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13610"
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_164251319.1"
                     /transl_table=11
                     /translation="MTYDQRPAYDLPTRRINPGAAGLTESDRELLLHLLALRTAGPLET
                     GGGEPVELWEAQSAYAEAAGRLGFRVVHHAPAGPDTVTGPDVPRAVGQAADTMPGFLDC
                     QPNMVLRLGPELPRAATVMFNVHMDTVAGGGPVSFTGSRFHGRGSIDAKGPAVGLLAGL
                     RAALAASPALGTEVGVLIQLVAGEEGGAMGVFGTKPLVEQGYVGRLNVFCEPTGFRVLS
                     RATASMTARLRVDGRDGIDDEPGAGHNATVLLGYLAQHLASELPPYAVDGQVCVAGMNT
                     GSMHNKVYGTGQLLINLSYGSQDTGRKLEAALDDVLRTGVERFRERFADSPTFATTARD
                     AASVTHLDWLKRGLPALYADDAWVGELLLDRAGLAPWPAELPAFTCDAIWLAGVPDTST
                     VVFGPGDLGANQAHAEGEFADLADLDRYARHIERLLISFARNRLDQGN"
     misc_feature    13920..13922
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14512..15684
                     /locus_tag="SSPS47_RS13445"
                     /old_locus_tag="SSPS47_13615"
     CDS             14512..15684
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040851.1"
                     /locus_tag="SSPS47_RS13445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13615"
                     /product="Ldh family oxidoreductase"
                     /protein_id="WP_164251321.1"
                     /transl_table=11
                     /translation="MTTTSTTTTAGSGAASAATTPRVDLTELVEFTAAVFRHHGLPAER
                     ALTAAQALVHGDLTGITSHGLTNLTRLYLKLFEDGRCDPAAEPEVLADRGAAVLLDAHR
                     ALGLWSASEAVDLAAERALQYGVGLVSVRDATHLGCAGAHAKRAADRGMICLLVSNCGQ
                     QRIIRPPGGQAALLGTNPLAFAAPAGARPPLVLDMSTTVVPTGRVRGAARAGQPIPEGW
                     LEDKDGRPVTDPHALDRGDGYLKWLGGDPATGAFKGYGLGLLVEVLGALLPGAGLGPAT
                     EAWSGSGSPSGQDDNIGFTVLVVAPAELRPQEDFEAQTAGMFDALVGSPAVDEARPVRY
                     PGWFEAERATEHGKSGVPLSAALFEELVTVAAERGLTAPKALEASPSQDT"
     misc_feature    complement(15794..15808)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            15799..16743
                     /locus_tag="SSPS47_RS13450"
                     /old_locus_tag="SSPS47_13620"
     CDS             15799..16743
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385637.1"
                     /locus_tag="SSPS47_RS13450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13620"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_147877035.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 9.1e-24, bitscore:
                     83.1, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.4e-12,
                     bitscore: 46.4, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPLRIGVVGLGVISRFYLDAFPGLPTLELVAVCDLREDALAPHR
                     AAGLPCYPDHRRMLAETELDAIVVNVPNDAHAAVCRDALEAGVAVCVEKPLALHLADGR
                     ALTELAVSGGSVLFTAFHRRYNDNVLGLLRSLPEAAAVESVTVRYLEKIEEHVGQDRWY
                     LDPERCGGGCVADNGPNAFDVVRLFLGELTVESAEVVRDGEGVDRQARVELRSAGGVPA
                     TVELDWSYPHGEAKDVTVRLKDGTEHHADMLAGHDAFKSSLKHEYVGVLQEFEQAVRAG
                     TDASRAGLAMLELVDATYRTERTGQNELTGAAT"
     gene            16743..17237
                     /locus_tag="SSPS47_RS13455"
                     /old_locus_tag="SSPS47_13625"
     CDS             16743..17237
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192620.1"
                     /locus_tag="SSPS47_RS13455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13625"
                     /product="hypothetical protein"
                     /protein_id="WP_147877036.1"
                     /transl_table=11
                     /translation="MNRTANGTANGTQVPALLAPSPENGDKRTVRSEVVKVLRHRRTDR
                     GMRLEEFASRCVREGELHELVTTDHLETEAGSRIDRVGFLGFVEISVSGVLDRGDIVLV
                     DGEPIGTLLGFDACHFPNHYNVLIHTAWTLTGPEAGLRPGSQISFRPPPPTDGDPGTGR
                     P"
     gene            17297..19081
                     /locus_tag="SSPS47_RS13460"
                     /old_locus_tag="SSPS47_13630"
     CDS             17297..19081
                     /EC_number="2.2.1.7"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020554085.1"
                     /locus_tag="SSPS47_RS13460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13630"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_164251323.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 5.3e-84,
                     bitscore: 280.3, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.6e-08, bitscore:
                     31.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALLDEIAAPRDLRGLSPAQLGQLASEIREVMIDAVCRSGGHLGP
                     NLGVVELTIALHRVFDSPQDTLLWDIGHQTYVQKLLTGRRAGFDGLRTRDGLSGYASRA
                     ESEHDVIENSHASTALSYADGLARARELSGDTDRAVVAVIGDGALTGGLAWEALNNLGG
                     APQRPVIVVLNDNERSYAPTVGGLAAHLGKLRSAGSAEVESDSANVFEEFGFGYLGPVD
                     GHDIAAVEDALERARALGGPVVVHVVTEKGRGWETAETNELDRCHVVRATPSANAAPAS
                     SLAWTAVFSDEMVRIGAERSDVVAITAAMAEPVGLLEFQREFPARTIDVGIAEQHAAAA
                     AAGLALGGLHPVLAIYATFGNRMIDQMVTDIALHSAPVTLVMDRAGVTGDDGASHNGMW
                     DLTLFQAVPGIRIAAPRDGATLRELLREAVAWDQGPTVLRFPKGTTGADIPAIDTTDGF
                     DVLHNAPGRDVLIVSVGPMARLALDVAGRLGEEGVGATVVDPRWVAPVNPTLVEAAAYF
                     KHVITIEDSGRTGGVGAAFGQALADAGIDTPVRNFGLPREFLDHGSRAQVLAHCGLTAD
                     AVTGAVLTRMTSERTLTS"
     gene            19078..20235
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="SSPS47_RS13465"
                     /old_locus_tag="SSPS47_13635"
     CDS             19078..20235
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266888.1"
                     /locus_tag="SSPS47_RS13465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13635"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_164251324.1"
                     /transl_table=11
                     /translation="MTAIALGMPDVPVKLADRRVSRQIQVGSVAVGGDAPVSVQSMTTT
                     RTSDIGATLQQIAELTASGCQIVRVACPTQDDADALSTIARKSQIPVIADIHFQPKYVF
                     AAIDAGCAAVRVNPGNIKQFDDKVKEIAGAASAAGTPIRIGVNAGSLDARLLRKYGKAT
                     PEALVESALWEASLFEEHGFRDIKISVKHNDPVVMVNAYRLLAARCDYPLHLGVTEAGP
                     AFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPAEEVKVGLQILESLNLKQRRLEIVSCP
                     SCGRAQVDVYKLADEVTAGLDGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIF
                     VKGEVIKTVPESKIVETLIEEALKIAAEMEANGVPSGEPLVVAGV"
     gene            20356..20568
                     /locus_tag="SSPS47_RS13470"
                     /old_locus_tag="SSPS47_13640"
     CDS             20356..20568
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004978947.1"
                     /locus_tag="SSPS47_RS13470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_13640"
                     /product="DUF4287 domain-containing protein"
                     /protein_id="WP_147878490.1"
                     /transl_table=11
                     /translation="MTETVKGPAAYFPSIERKYGRPVAEWKELIRSSPLTKHMELVSWL
                     KTDHALGHGHANALVAHTLAEDAGK"
     gene            complement(20624..20815)
                     /locus_tag="SSPS47_RS35330"
     CDS             complement(20624..20815)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSPS47_RS35330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_239064887.1"
                     /transl_table=11
                     /translation="MERIGFFFEATDWAGDPVNREPAKCLALQWFSVHELPEDIIEYPK
                     EGLLGYLEGSGALAEHGW"
     gene            complement(20852..21064)
                     /locus_tag="SSPS47_RS35335"
     CDS             complement(20852..21064)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="SSPS47_RS35335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_239064888.1"
                     /transl_table=11
                     /translation="MNPHPAQPVIDTHVLLRDGDKLLFSQRGGPYGHGRWHMPSGKLDR
                     GETISAGAARELMEETGVRVDPARL"
ORIGIN
        1 gctctcctcg ccctcttcga gcagggtgtc ggccggaccc acgatgagcg ggtcgggctc
       61 gccgacggcc gactcgtcct tcagctcgta gtccacccgc cacagcaggc tgcgcatggc
      121 ctccagccgt ccccgcttct tgtcgttgtt cttgaccacg gtccagggcg cgtgcgccgt
      181 gtcggtggcc cggaacatgt cgaccttggc cgcggtgtag gcgtcccaga ggtcgagcga
      241 cgcgaggtcg gtgggcgaga gcttccactg ccgtacggga tcgatctgcc ggatcgcgaa
      301 gcgggtgcgc tgctcgtcgt gcgagaccga gaaccagaac ttgaccagca ggatgccgtc
      361 gtcggtgagc atccgctcga actggggcgc ctggtggagg aagtgctcgt actcggccgg
      421 ggtgcagaag cccatcaccc gctcgacacc ggaccggttg taccaggagc ggtcgaagaa
      481 gacgatctcc ccggcggagg gcagatgcgc gacgtaccgc tggaagtacc actgcccggc
      541 ttctcgctca gtgggcttct ccagggccac cacgcgggcg ccacgcgggt tgagccgctc
      601 ggtgaaccgc tggatggtgc cgcccttgcc cgccgcgtcc cggccctcgc agaccacgac
      661 cacccgctgg ccggtgtcct tgacccagcg ctgcaacttg agcagttcga tctggagcgt
      721 acgcttcgtc cgctcgtact cgcggcggcg catcttcttc tcgtacgggt agttctgccg
      781 ccatgtcctc acagggcgac cggacttgtc gagcaggacg ggctgctggg ggtcccggtc
      841 gtcgaccgtc agcccgtcga ggaggacctt ctcgacgtcc tcatccggcg acatgcgggg
      901 gccttccccg gtagggggtg gtgacggtgc tggggtcggc ttcctcctcc tcgtcgagcg
      961 gggggaggtc gatcgtgtac tgcgcctcca ggaagaggtc gctgtgctgc ggacgcgaaa
     1021 cggactcatc tgcggcggga agaggcgcgg ttcggacgat acgacgctga gagctctgca
     1081 tccaagacca tccagggaaa gggagtcgca cggggccgcg cggccattgc cgggcgacag
     1141 tctcatcctt acacagggct cgatcttgac gagcgagccg aaatgcccgg tgggcaccgt
     1201 gatcggcgtc ccgggccacc gcccggtcct tgatcaccgg acccgccggg tcagtccgcg
     1261 ggccggtcgg tgcggtggcg gccgagcacc cggtccacca actggcccgc cgcgcccgtg
     1321 tagtgcgccg gatccgacag cttgcggagg tcgtcggccg atcgacggcc ggccaggccg
     1381 ggggtttcgg ccaggacgtc cgcgaggtgc ctgccggagc cggcggcctc tgccgacgcc
     1441 cgcccgagca gggccttcgc ctcggccctg ccgagttcga cggagagcag ggccgcgagc
     1501 cgttcggaga cgaccagacc gcccgtcagc tccagattgg ccagcatccg gtcctcgtgg
     1561 acggtcagac cctccgtcag ctccgcggcg gtgtgcgccg cgccgcccgc caggcgcagg
     1621 cagtcgcgca gcggcagcca ttcggcgtgc caggccccgg agggccgctc gtcgtcgtgg
     1681 accgacacct gcatgagggt gccgacgagg gagggcacct ggtaggaggc cgcgcggatc
     1741 agtgccgaga gcgcggggtt gcgcttgtgc ggcatggcgg aggacgtgcc ccggccctcg
     1801 gcggccggtt ccgccagctc gcccgtctcg gtgcgggaca gcagctggac gtccgccgcg
     1861 ataccgccga gcgcgccggt cagcagggcg agcgccgcgc cgaggtcggc gaggggcgtt
     1921 cggacggtgt gccagggcac gagcggttcg gtgaggtcca gctccgcggc gagcgcgccg
     1981 ggcagctcct cgatgcagcg ccgcccgccg tcgtcggcgg cgtccggtgc gtgcaggagc
     2041 gcgtactcca gatatccggc catcgtgccc gccgcgccgc cgagttggac cggcagcccc
     2101 tgggcgcgca cccggcgcag ccggtcccgt gcgtcgagca caccttggag ccagccggcg
     2161 gccttgagac cgaacgtggt cgggacggcg tgctggccga gggtgcgggc ggccatgggg
     2221 gtgtcgcggt gccgggcggc gagccgggcc agcgcggcgg cggtccggtc caggtcggcg
     2281 aggacgaggt cgagggtgcg ggcggcgacc agcatgaggc cggtgtcgag gatgtcctgg
     2341 ctggtggagc cctggtggac gctgtgggcg gcgtcggcgt ccgcggccgc gaccagcgcg
     2401 gtcagccgcc gtacgagagg gacgaccggg ttggcggcgc cgcgcgcctg gaccgccagc
     2461 tcgtagaggt cgaagtgttc ggcgcgcgcg gcctcgccga tggcgcgggc ggcggactcg
     2521 ggtacggtgc cgagccgggc ctgtacccgc gcgagggccg cttcggtgtc gagcatggcc
     2581 tggaggcacg cggtgtcact cgtggcggcc tcggccgggg tgcccgaccg gaccggcgag
     2641 aaaagccctg tgtcggccgg gggctgactg ttcgtcatgt ctgaatcctc gtcaactcgc
     2701 gctctgctga gatggtttca cgtggtcctg gacttctggt ggtccgtcac cggaggccgg
     2761 ggcgggccgg cgggcagggc caggacggcc agggagatcg cgtcggagtc acccagggtc
     2821 accgagttga caccggggcg gaccccggcg gcggtcgccc agtgcacgga ctcggtcggt
     2881 acaccgtagg cgaagcgccg ggggtgggcg cgaccctcgg tgtccaccag ccggtagggc
     2941 cggggcgtga cggccaggcc gccggtctcg tacgcgccga gttccgggtc ggctatcgcg
     3001 taggggcggc actgccccgt ggccagcagg tcggtcagca gcgggtcggt cgtccggcgc
     3061 aggtcgggct cgggcagccg ggcctcgacc agggtggtga cgcgggtcgc ggagccgggc
     3121 acggcgggcg cctcgacggt gaagacgccc tggtccgggt cggtgccgac gcgcatgtcg
     3181 gggccgagga cgtccagcac cccggcctcg atgagcgcga tcatctgctc gatccgggcg
     3241 gccggcggtc cgatggacag gaaggcgttg agcggggtgt accagcgctc caggtcgtcg
     3301 cggtgcgagc tgccggtgag tccgccgtgg tcgaccacca ggcggatctc gttgcgcagg
     3361 tcccgcagta cgtcgagggc ggacttgagc gggccttcga cgttgcccgc ctcggactcg
     3421 gcgagatccc ggcgcaggat gtccagcagc cattcgcggt ggtccccggc gctcctgaac
     3481 ccctggtcgg cgtggggcag ggagaggtgc ttccagtccc agtgggcctc ggggccgatg
     3541 ccgtacgcgt cgagcaggtc ggactcctcg gccgatcccc aggccggttt cagataccgg
     3601 tcgccgaacc ggccggcctc gctcccgccg acgcgccggg cgagcagcgc cgtgtagtag
     3661 acggtctcga cctccttggc gatcagcggc cacaggtcgc ggccgaagtc gagtccgccg
     3721 ccgagccggg cggcggtgcg cagccgctcc agcacctccg gggtgaggac ccgtgggatg
     3781 tgccggccgt gcgcgccctt ctggttgcgg ccccgtgagt ggtacgggat gccgcgccgg
     3841 gaggcggcgt acaggcgcgg ttcgcgtccg gacgggccgt agacgagccg gccgtcctcg
     3901 cgggtgtacg tgccgccccg gccgagcgtg aacagtgtca gatggtcgaa gaagttgagt
     3961 ccgagtccgc gcagggcgac ggcctcgccc ggccggacgg cggacaggtc ggtgtcggcg
     4021 gggttggccg gcgggacgta ggtcagcgcg tgggtccgcg cgaagtcggc gagttcgcgc
     4081 tcgccggggc cgccccggac ggggaggtgg ccctgggcca ggacgaccgc gtccaggccg
     4141 tcgacgcggg agccgtcggc gaggcacaga ccctgcgggc cgtcgggggc gccgtccagc
     4201 cggaccgccc gcgacgggtg gacgacgacg cggacgtgcg cgggcgcggt gcggacgacg
     4261 tgccggaaga cccactccag gtagtggccg tagaaggcgc gggtcgggta ggagtccggg
     4321 gtgaggtcgc gggcctcggc gcgcacctgg tcgtcgtacg cctccccggt gccctccccc
     4381 ggcgccgccg ccgtccggac cgcccagtcg tacaggctgg ggccgggggc gagttcgccg
     4441 tcgatctcca cgctctcgtc ggtgaacagc gtgacctgcg aggcgacggt gttcatcagc
     4501 agatggtggg actggtcggt gcgccacacc ccgcccgcgc cggggcggtg cgggtccacg
     4561 atgtgcaccg tgagggtgga gccgtccggc agcccccggc gcgcgttgac gcagagccgt
     4621 tccagcaccg agagcccacg aggcccggcg ccgacgatgc agacctccag atgtccgtca
     4681 ctcacgtccg tgtctccgtc tcccgttgga cggcctggtt agcggccggt ctctcgctcg
     4741 cctgatcacc gctcggagga ctgcacaggg gcttcagagg acttcgacgg tggggccggt
     4801 ctccagccgg tgccggcagt ccaggacgaa ctccgaggcg cgggcgacga gttcgtagtc
     4861 gaaggcgtcg tggtcggtca gcagcaccac cgcgtcggcc gccgccagct cctcctcggt
     4921 gaagtcgcag cgggtcagcc tgctgttcac ggtgaccgcc tcgaccacgt acgggtcggc
     4981 cgcgcgcact tcggcgccga gaccgagcag cagctccgcc acgcgcagcg cgggcgactc
     5041 gcgggcgtcg ccggtgttcg gcttgtacgc gaggccgagc agcaggaccc gggagccggc
     5101 cagcggcctg cggcgggcgt tgaaggcgag cagcagccgc tggaccacgt ggtcgggcat
     5161 gtgtccgttg atctcgttgg cgagttcgac gaactggaag ctgcggccga gcgtgcgcct
     5221 gacccgccag gacaggtatt cggggtcgac cggaagacag tgtccgccga ccccggggcc
     5281 gggggtgaag cgcatgaagc cgaagggctt ggaggcggcg gcgtccagcg cctcccagac
     5341 gtcgacgccg agttcgtgcg cgtacatcgc catctcgttg accagggcga tgttgacgtg
     5401 cctgaaggtg ttctcgatca gcttggacag ctcggcgacc tcggtcgtgc gcaccggcac
     5461 ggtgttgctg gtgatcgtgt cgtagaaggc ctgtacggcg gtgagcgacg ccgagtcgat
     5521 gccggagacc accttgggcg tgttctccag gcgccaggtg gggttgccgg ggtcgatgcg
     5581 ctcggggctg taaccgaggt ggaagtcctg gccggcgacg aggcccgagc cctcctcgag
     5641 cagcgggacg aggagttcga cggtggtgcc ggggtacgtg gtcgactcca ggaccacggt
     5701 cgcgccgggg cgcagccggc ccgcgagggt gtgggcggcc gactcgatgt acgagaggtc
     5761 gggggcgccg tcccgcagcg gggtgggcac ggtgacgacg gcgatgtcga agccgtcgag
     5821 gtccgtgggg tcggtggtgg gcaggtaggt gccccggtcg agcaggacgg cgagctgtgc
     5881 gtcggggacg tcctcgacgt aggactcacc gctgacgagc cgtttgacgc gttcggtgtc
     5941 cacgtcgtag ccgaccacct ggtggccggc ctgagcggcc cggacggcca gcggcaggcc
     6001 cacgtacccc tgcccgacaa cgacgacctt gcttttcacg gttgctcccg tcggagaaga
     6061 ttggtcagtt ggtcagggtc gggcgacagc ggtcggcggc ggcgggcggg ccggagcggc
     6121 cgagcgcgcg cagggggggc cgcgccggtg gtcagtcgaa gaaggcgcag accacatcgg
     6181 ccgtacgctc gacctgactg tccgtcagac tgagattgag cggcagcgcg agatggcgcg
     6241 cgctcgccag ttcggtgccg ggccgccgtc cgtccgcgcc ctccccggcg tacgcggcga
     6301 aggcgggcag cctcggcagc gggaccgggt agtacacgcg gctgccgatg ccgtgcgcgg
     6361 cgaggtgcgc cgccagcgag tcccggcaga tggtctgtac ggcgtagaca tagtggcact
     6421 ggccgtcggc gccggtggtg ggggcgagca ggccgctccc gcgcagcgcc gcgaaccgtg
     6481 agttgtagtg cgcggcgatc gcggcgcgcc gggcgaccat gtcgtcggcg cggtccagcc
     6541 gggcgagctg gtagccggcc agcacctcgt cgaagcggct gttgagaccg acctcgtggt
     6601 gcacgaagcg ctgcacaccg tcctgcccgt ggttgcgcaa ccgtcgtacc agcgtggcga
     6661 gttcgatgtt gccggagagg accaccgcgc cttcgccggg cattccgaac ggcttgacgg
     6721 ggaagaacga gtagagcccg atgtcacccc aggtgcccgc cgcccggccg cccagggtgg
     6781 cgccctgggc caccgccgcg tcctcgacga ccgcgatgcc gcgccgccgc gcccaggcca
     6841 tgatcgcggg catgtcggcc atcgtcgtga aggtgtgggc ggggacgacc gcgcgggtgc
     6901 ggtccgtcac ccggctctcc gcgtcgacgg ggtccatgac catcgtcacc gggtcgacgt
     6961 cggcgaagac cggcaccgcg ccgacgccga gcaccgtcgc ggccagcggc tccgcgccga
     7021 aggccggcac gatcacctcg tcgccgggga cgacgccgac ggcccgcagg gcgaggacga
     7081 gggcgccggt gccgctggcg caggcgacga cgtcgcgcac acccgcgcgg tcggccagcc
     7141 gccgctccag ttcggcggtg cggcggccga gtatgaactt ctgctcgggg tcggtaccga
     7201 cctcgtacag cacctcgcgc agcagttcac ggtccgcgtc ggggagccgg gtgtacgcgt
     7261 aggggacggt ctcggtggtc gccgtggccg cggcgacgcg gatcggggcg gcctgtgcgg
     7321 ccgaggtctc ggtggtcatg acgtactccc ggtgaagaag gagcggacgg cgtcgcacac
     7381 ccggccgagc tgcgcgaggg tcagctcggg gtagagcggc agcgccacgg tgcggtggct
     7441 ggcggcctcg gcgtgcggga agtcaccctc ctggtggccg agatgggcga agcacggctg
     7501 gaggtgcagc ggcagcgggt agtacgtctc ggtaccgatg cccgcggcgg cgaggtgcga
     7561 gacgagggcg tcgcgccggt cggtctcgat gagatagacg tagaagaccg gatccaccgg
     7621 ctcgccgcgc tccacgaccg cgggcagccc gcgcacaccg gggatgccgc gcagcctgcg
     7681 ggtgtacgcg tcggccagca cggcgcggcg gcggatgtcg tcgtccagcg tggtcagctt
     7741 ggtgagcagg gccgcggcct ggagttcgtc catcttgctg ttggtgcccg ccagttcgcc
     7801 ctgccgcgcg tattcggcgc gtgcggccgg ggcggcggcg ggcctggcgg cgggggccgg
     7861 gggcggcagc gcgggccgac cgtggtcgcg cagccgctgg acggcgccgg cgagagcgtc
     7921 gtcgtcggtc agcaccatgc cggcgtcgcc gagcgcgccg agcgtcttgg tggggaagaa
     7981 cgacagcacg ccgcccaccc cgatcagacc ggtgtggcgt ccgtccagcc gcatcccgat
     8041 gccctcggcg ctgtcctcca ggacgagcag gccgtggcgt tcggcgacgg cgaggaccgc
     8101 cgtcatgtcg gcgggctggc agaacagatg gaccggcatg acggccttgg tgcgcggtgt
     8161 gaccagcgct tcgagggcgg ccgggtccag gttgtaggtg agcggatcga cgtcggcgaa
     8221 gacgggcacc gccccgacga gcgccacgga gctggccgac gcgaagaagc tgaaggccgg
     8281 cacgatcacc tcgtcaccgg ggccgatccc cgccgcgcgc agcagcagga ccagcgcgtc
     8341 ggtgccgttg ccgacggcta tcgcgtgccg ggcaccggtg taggcgcgca gcgcggcctc
     8401 cagctcggcg gtcttcggcc cgttggagta cgtccccgac tcgcagacct cgtcgagata
     8461 cgcgctcagc cggggccaca aacgctcgaa ggattccgcc tgcgtgaaga acgggacggt
     8521 gctcgccgga gccggcatcg ccttgctgtc catttcactc cactcgtctc ggcggtgctg
     8581 ggcggaatcc acggttctac ttgtcggaac tgctcgtccg gaactccgcg gttctgctcg
     8641 cttacgtccg atcgaacgta gaccgcgcgc cgacacccct tcgatagcaa tcacccggca
     8701 atccattggc agttgcgggg gacagtgcag gcaagagcgt gcagaacact gcctattacc
     8761 tggctccttg cttattgccg gtccgaaaaa ccttgacttg cctcttcggt gtggtcgacg
     8821 gtgaagccca attccacgga ccgacaggag ttttcagtcg tgaccgacat cgtgtccgac
     8881 aagaaagtga tcctcgccga gccacgcgga ttctgtgcgg gggtacgccg ggcgatagaa
     8941 atcgtcgaga aggcattgga ggtccacggc gctcccgtct atgtgcgaaa agaaatcgtc
     9001 cacaaccact acgtggtggg ggtgctgaag cggcgcgggg cgatcttcgt ggactccgag
     9061 gcggaggtgc cgcccggcgc ggtctgtgtg ttctccgcgc acggggtggc cccggaggtc
     9121 cgcgagaacg cgaaggcccg ccggctcgac accatcgacg cgacctgccc gctggtgtcg
     9181 aaggtccacc aggaggcccg gcgctacgcc cgcgacggcc gcaccctgct gctggtcggc
     9241 cacgccgacc acgaggaggt cgagggcacg tacggcgagg cccccgaccg cacggtgatc
     9301 gtggagagcg aggagagcgc gcggcagctc gacctgccca gtgacacccc ggtcgcggtg
     9361 ctcacccaga cgacgctgtc gatggacgag accgcgggca tcgtcgcggt gctgggcgag
     9421 cgcttcgacg atctgcggag cccggccgac ggcgacatct gctacgcgag caccaaccgg
     9481 caggtcgcgg tgaaggagat cgccgcgcgc agcgatctcg tgctggtcgt cggatcgcgc
     9541 aactccagca actcggtacg gatggtggag gtcgcccttc tcgaagggac cgccgcccat
     9601 ctggtgccgg acgtcaccga actcgacgtg agctggctgg acggggtgac gacgatcggt
     9661 gtgagcgccg gcgccagcgc gcccgagctg ctggtcgacc aactgctgga gcggctggac
     9721 gagttgggct accaggacgt ggagctgtcc gtgacgacca aggaggacat cgtcttccag
     9781 ctgccgtcgg gactcagcca ggcacgtccc tccgcctgat acgtccgccc gatccgtccg
     9841 cccctccgac aggagccgta cggctcgcgc cgctcatgtg ccggagccgg cgccgcgagc
     9901 ccggagcccc acgcctcgga gccgtacgcc tgagaacacg ggcccggcgc cacgaggacc
     9961 agatcgccgg cacgacagcc gacacgacag gagaacgctc atgaccgtct caccgcccgc
    10021 accggccgtc gggcacctcg gagggctcgc cgcgcagtcc cgcgcggccg tcctggaccg
    10081 taccgaggag cgcctcgacg ccatgctcgc cgcggagcac tcccgctggg cggcggtcga
    10141 cgcgcgcgcc gcggtccccg tcgacgccat cggcgagctg atccgggccg gcggaaaacg
    10201 cctgcgcccc gcgttctgcg cggccggctt cctggcggcg ggcggtgagc tgtccgactc
    10261 gcgcgtggtg gacgcggcgg cggcgatcga gatgctgcac gcgttcgcgc tcatccacga
    10321 cgacgtcatc gacgactccg acctgcgccg cggcgagccc acggtccatg tccagcacat
    10381 cgagcggcac cgggcacagg gctggcaggg cgaggcccgc cgttacggcg agggcatcgc
    10441 cgtactcgcg ggtgacctgg ccttctcgta cgccggacag ctcatccagg acctgcccgc
    10501 cgaggcccgg ctggtctggg gccggctcgt cagcgagatg atcatcggcc agcacctgga
    10561 cgtgacggtc gccgcggaat ccctcccgga cccgaagctg gcccggtaca tcgccaacgc
    10621 caagtccggt cactacagca tccatcgccc gctggagctc ggcgcggcca tcgcgggcga
    10681 cacctcgtcg gccgccgcct tcgaggcgta cgggaccgcg ctcggcgagg cgttccagct
    10741 gcgcgacgac ctcatcgaca cctacggcga cgcggacgcg gtcggcaagc cggtcggtct
    10801 ggacgccgaa cagcacaaga tgacgctcct ggtgagcctc gccgcgctgc gcgacccgcg
    10861 cgtcggcgag ctggtgcagg ccgccgagtg ggacggcgcc gcgctggccg aggcgctgac
    10921 cagcagcggc gtacgcgccg aagtggagca ccggatcgac gagttggtgg tccaggcgca
    10981 cgaggcactg tcggcggcgc ccatcagcga cgagtggaag cgcgaactcg ccgacatggc
    11041 cacgtcggtg gcctaccgcg accactgatc cgacagcccg ttccctttct ccccagacgg
    11101 cagatctcct cgagagcgaa ggtcacgtca tgctgaacac gttcatcgtc ggcggcgggc
    11161 gggccggcct cgggctgcac tggccggtgc tgcgcaagct gcgcgccctg ccggacggaa
    11221 gcggtccgtg gtcaccggac ccgcccgtga tctgggacgt ccaggacatc cgcgaacagg
    11281 ccctggccga gggcctggtg ccggcggact cactggccca cgccgccgag ctggcggacc
    11341 ccgccaccac ggtcgtgcat ctgtgcacgc cgccggccga ccggttcgcc acgctccagc
    11401 agctggccga cctcggctac acgcgcatcg tggtcgagaa gccgatggcc gacgacatcg
    11461 ccggtctgga ggccatcgac atgctggcgc gggtgcgcgg tctgcggctg cgggtcgtct
    11521 cgccgtggct ggccagctcg ctcacccggg agctggccga gctgacgcgg tacggcgctc
    11581 tgggcgagct gcgttcgatg tccttcacgc agttcaagcc gcgctggacg cgcaccctgc
    11641 gctccaacaa ccacaccacc gccttcgacg tggagctgcc gcactcgctc ggtgtcgccc
    11701 tgcggctcgc gggggacgca cggatcaccg acgcggcgct gacggacatg cggatcggcg
    11761 acaccgtcat ccccgacatg ggcggcgccc ggctgacgct ccagcacgac aacggcgcca
    11821 ccacggagat agcctccgac ctcacctcgc cgatccgcga acgccgtgtc gggctgcggt
    11881 tcgacaccgg ccacgtcgtc ggccactacc cgatcagcga tgtcgaccac cacgccagcc
    11941 tgaccgtcca cgacgacgcg ggcggcggtg cggcggcccg caggctcctc ttcgacgacg
    12001 cgctgaccag ctacatcgac cacgcctacc aggagtacca ggcggtcgac gcgggcaccg
    12061 acggcgcttc gggcagtggc ggccccggta acggcgctcc cggcggggtg aacgacatgg
    12121 acgactacgc gatcgcccgg cgggtcgtcc aactgctgca agaggcacgg ctgttggccg
    12181 ccgcgcagag tagccgcgca gactcggccg cgcccgtgcg gccaccgctg accggcgtct
    12241 cccccgcgct ccaggggggt gccgaccatg agggctgaca tccgtctgag cggcatcggc
    12301 gacgaggcgg ccccggggct cgaccggcag atcgaggcgg tacggcggct cggctgggac
    12361 agcgtggagc tgcgctcggt cgacggcgtt cccctcgccg aactcgacgg cccggccttc
    12421 gaccgggtgg ccgggtcggt cgccgaggcc gggctcggag tctcctgcgt cgactcccgg
    12481 atcggcaact gggcccgtac ggtcgtctcc ccgttcgccg acgacctcga cgagctggcc
    12541 cgcctggccg atcgctgcga gcgcctcggc acccgctacg tacggatcat gtcctacccc
    12601 aacgccggtc tgccggacgc cgattgggag cgggaggtgc tcgaccgggt acggcggctc
    12661 accgcgcgcg ccgaggacgc agggctggtg ctggtgcacg agaactgcgc cggctgggca
    12721 gccaccgacc cggcgcggat gctccgtctc ctggaggcgg ccgacagccc cgcgctgcgg
    12781 ctgctcttcg acgtcggcaa cggcatcgcg tacggctacg aggcgtacga ccatctcgcg
    12841 cacatcgcgc cgtacgtcgc gcacgtgcat gtgaaggacg gtacgggcga cacgagcgcg
    12901 cagttctact cgctgcccgg cgacggggac tgccgggtcg cggactcgct gcggctgctg
    12961 ttcgaccagg gctactccgg cgccgtctcg atcgagccgc acatcaacat ccgcccccac
    13021 gagggatggt cggacccgtc cggggactac gtggacgagt tcgtgacgta cgggcagcgg
    13081 ctcgagaagc tcctgcgcga gctggagccg gccacggaca gcggcatctg acagaccgtc
    13141 tgcaaaagag agggggaccc cgcatgacct acgaccagcg tccggcctac gacctgccga
    13201 cccggcgcat caatccgggc gccgccgggc tgaccgagtc cgaccgggaa ctgctcctgc
    13261 acctcctcgc cctgcgcacc gccggaccgc tggagaccgg cggcggggaa ccggtggagc
    13321 tgtgggaggc gcagagcgcg tacgcggagg cggccggccg gctcggcttc cgggtcgtcc
    13381 accacgcccc cgccggaccc gacaccgtca ccggcccgga cgtgccccgg gcggtgggcc
    13441 aggcggccga caccatgccc ggattcctcg actgccagcc gaacatggtc ctgcgtctgg
    13501 gccccgaact gccgcgcgcc gccacggtga tgttcaacgt gcacatggac accgtcgcgg
    13561 gcggcggccc ggtctccttc accggttcgc ggttccacgg ccgcggttcc atcgacgcca
    13621 agggccccgc cgtcggactc ctcgccgggc tgcgggccgc actcgccgcc tcccccgcgc
    13681 tcggcaccga ggtgggcgtg ctgatccagc tcgtcgcggg cgaagagggc ggcgccatgg
    13741 gggtgttcgg cacgaagccg ctggtcgagc aggggtacgt ggggcggctc aacgtgttct
    13801 gcgaaccgac cggcttccgc gtactgagca gggccaccgc ctccatgacc gcacgcctgc
    13861 gcgtcgacgg ccgcgacggc atcgacgacg agccgggcgc cggccacaac gcgacggtgt
    13921 tactgggcta tctcgcccag cacctcgcgt cggagctgcc gccgtacgcg gtcgacggac
    13981 aggtctgcgt cgccggcatg aacaccggct ccatgcacaa caaggtctac ggcaccggcc
    14041 agttgctgat caatctgtcg tacggctccc aggacaccgg gcgcaaactg gaagccgcgc
    14101 tggacgacgt actgcggacc ggcgtggagc gcttccgcga acgcttcgcc gacagcccga
    14161 ccttcgccac caccgcccgc gacgccgcga gcgtgacgca tctggactgg ctcaagcgcg
    14221 gactgcccgc cctgtacgcc gatgacgcgt gggtcggcga actgctgctg gaccgggcgg
    14281 gactagcgcc gtggcccgcc gaactgccgg cgttcacctg tgacgcgatc tggctcgccg
    14341 gcgtgcccga cacctcgacc gtggtcttcg gccccggcga tctcggcgcc aaccaggccc
    14401 acgcggaagg tgagttcgcc gatctggccg acctcgaccg gtacgcgcgg cacatcgagc
    14461 gcctgctcat ctccttcgca cgcaatcggc tggaccaggg gaactgacct catgacgacg
    14521 acctcgacga ccacgaccgc cggctccggg gctgcttccg ccgccacgac accgcgcgtc
    14581 gacctcaccg agctggtgga gttcaccgcc gccgtgttcc ggcaccacgg cctgcccgcc
    14641 gagcgggccc tgaccgccgc gcaggccctg gtccacggcg acctgaccgg catcacctcg
    14701 cacggcctga ccaacctcac ccggctctat ctgaagctct tcgaggacgg ccgctgcgac
    14761 ccggccgccg agcccgaggt gctggccgac cggggcgcgg ccgtcctgct cgacgcgcac
    14821 cgcgccctcg gcctctggtc ggcgagcgag gccgtggacc tggccgccga gcgcgccctc
    14881 cagtacggcg tcgggctcgt ctccgtacgc gacgccaccc acctcggctg cgcgggcgcg
    14941 cacgccaagc gcgcggcgga ccgcgggatg atctgcctgc tcgtctccaa ctgcggtcag
    15001 cagcgcatca tccggccgcc cggcggacag gccgccctgc tcggcaccaa cccgctcgcg
    15061 ttcgccgcac ccgccggggc gcgaccgccg ctcgtcctcg acatgagcac caccgtcgtc
    15121 ccgaccgggc gcgtccgcgg cgcggcgcgg gccggacagc cgatcccgga gggctggctg
    15181 gaggacaagg acggccggcc ggtcaccgac ccgcacgcgc tggaccgggg cgacggctat
    15241 ctgaagtggc tgggcggcga tccggccacc ggggcgttca aggggtacgg gctcggtctg
    15301 ctcgtcgagg tcctcggcgc gctcctgccg ggcgccggcc tcggcccggc gaccgaagcc
    15361 tggtccggca gcggcagccc cagcggccag gacgacaaca tcggcttcac ggtgctggtc
    15421 gtcgccccgg cggagctgcg cccgcaggag gacttcgagg cgcagacggc cggcatgttc
    15481 gacgcgctgg tcggctcccc ggcggtggac gaggcccgtc cggtccgcta ccccggctgg
    15541 ttcgaggcgg agcgcgcgac ggagcacggc aagagcgggg tcccgctgtc ggcggccctg
    15601 ttcgaggagc tcgtcacggt ggcggcggaa cgaggcctga cggcgccgaa ggcgctcgaa
    15661 gcaagcccgt cacaggacac gtagcccgcc gagcgcccgg tctgtccggc gagtgaggac
    15721 acagcacgca gcccgtccgg cgagtgagga catccacccc ccggacaccg gcaatcgcgt
    15781 ccaaggagga cacagaaaat gaaacccctg cggataggcg tggtggggct cggggtcatc
    15841 tcccggttct acctcgacgc cttccccggc ctgcccacac tcgaactggt cgcggtctgc
    15901 gacctgcgcg aggacgcgct ggccccgcac cgcgcggcgg ggctgccctg ctacccggac
    15961 caccggcgaa tgctggccga gacggagctc gacgcgatcg tcgtcaacgt ccccaacgac
    16021 gcgcacgcgg cggtctgccg cgacgcgctc gaagcgggcg tcgcggtctg cgtggagaag
    16081 ccgctcgcac tgcacctggc cgacggccgc gcgctcaccg aactggccgt gagcggcggc
    16141 tcggtgctgt tcaccgcgtt ccaccggcgc tacaacgaca acgtgctcgg cctgctgcgt
    16201 tcgctgcccg aggcagcggc ggtggagtcg gtgacggtgc gctatctgga gaagatcgag
    16261 gagcacgtcg gccaggaccg ctggtatctc gaccccgagc gctgcggcgg cggctgcgtc
    16321 gccgacaacg gccccaacgc cttcgacgtc gtacggctgt tcctcggcga gctgacggtc
    16381 gagtccgccg aggtcgtacg cgacggggag ggcgtcgacc ggcaggcgcg ggtggagctg
    16441 cgctcggccg gcggggtgcc cgccaccgtc gagctggact ggtcgtaccc gcacggcgag
    16501 gcgaaggacg tcaccgtccg cctgaaggac ggcaccgagc accacgcgga catgctcgcc
    16561 gggcacgacg cgttcaagag ttccctgaag cacgaatacg tgggtgtgct ccaggagttc
    16621 gagcaggcgg tgcgcgccgg tacggacgcc tcgcgcgccg ggctcgcgat gctggagctg
    16681 gtcgacgcga cgtaccgcac ggagcggacc gggcagaacg agctgacggg ggcggcgacg
    16741 tgatgaacag gacggccaac gggactgcca acgggacaca ggtccccgcg ctgctggcac
    16801 cgagcccgga gaacggcgac aagcgcacgg tcaggtccga ggtggtcaag gtgctgcggc
    16861 accgccgtac ggaccgcggt atgcgcctgg aggagttcgc ctcccgctgc gtgcgcgagg
    16921 gcgagctgca cgaactggtc accaccgacc atctggagac cgaggccggc tcccgtatcg
    16981 accgggtcgg cttcctcgga ttcgtggaga tctcggtgtc cggggtgctg gaccggggcg
    17041 acatcgtcct ggtcgacggt gagcccatcg gcaccctgct gggcttcgac gcctgccact
    17101 tccccaacca ctacaacgta ctgatccaca ccgcctggac gctcaccggt cccgaggccg
    17161 gcctgcggcc cggctcgcag atcagcttcc ggccgccgcc gcccacggac ggcgacccgg
    17221 gaactggccg gccctgacag atccgcacca ccgccgcacg gacacgtcgg ccatctcgga
    17281 catggagggt tcagtcatgg cactactcga cgagatcgcg gctccccgcg atctccgcgg
    17341 tctctcgccc gcgcagctcg gccagctcgc ctcggagatc cgggaggtga tgatcgacgc
    17401 ggtgtgccgc tccggcggac acctcgggcc caacctgggc gtggtcgagc tgaccatcgc
    17461 gctgcaccgg gtcttcgact cgccgcagga cacactgctc tgggacatcg gccaccagac
    17521 ctacgtacag aagctgctga ccggccggcg cgccgggttc gacggtctgc gtacgcgcga
    17581 cgggctgtcc ggctacgcct cgcgcgccga gtccgagcac gacgtgatcg agaactcgca
    17641 cgcgtcgacg gcgctcagtt acgcggacgg gctggcgcgc gcccgcgagt tgagcggcga
    17701 cacggaccgc gcggtggtcg ccgtcatcgg ggacggagcg ctgaccggcg gtctcgcgtg
    17761 ggaggcgctg aacaacctgg gcggcgcgcc ccagcggccg gtgatcgtgg tcctgaacga
    17821 caacgagcgc tcgtacgcgc cgacggtggg cggcctggcg gcgcacctcg gcaagctgcg
    17881 gtcggccggg tcggccgagg tcgagtccga ctcggcgaac gtcttcgagg agttcggctt
    17941 cggctatctc ggcccggtcg acgggcacga catcgccgcc gtcgaggacg cgctggagcg
    18001 tgcgcgggcc ctgggcggtc cggtcgtcgt ccatgtggtg acggagaagg gccgcggctg
    18061 ggagacggcc gagacgaacg agctggaccg ctgccatgtc gtacgggcga cgccgtcggc
    18121 caacgccgct cccgcgtcga gtctcgcgtg gacggcggtg ttctccgacg agatggtacg
    18181 gatcggggcg gagcgctccg atgtcgtggc gatcacggcg gcgatggcgg agccggtagg
    18241 actgctggag ttccagcggg agttcccggc gcgcacgatc gacgtcggca tcgccgagca
    18301 gcacgcggcg gcggccgccg ccggtctggc gctcggtggt ctgcacccgg tgctggccat
    18361 ctacgcgacg ttcggcaacc gcatgatcga ccagatggtg accgacatcg ccctgcactc
    18421 ggccccggtc acgctggtga tggaccgcgc gggcgtcacc ggcgacgacg gcgcgagcca
    18481 caacggcatg tgggacctga cgctgttcca ggccgtaccg ggcatccgta tcgcggcccc
    18541 gcgcgacggc gcgacgctgc gcgagctgct ccgcgaggcg gtcgcctggg accaggggcc
    18601 gacggtgctg cgcttcccca aggggaccac cggcgcggac atccccgcga tcgacacgac
    18661 cgacggcttc gacgtgctcc acaacgcgcc aggccgcgac gtgctgatcg tctcggtggg
    18721 cccgatggcc cggctcgcgc tggacgtcgc gggccggctg ggggaggaag gcgtcggggc
    18781 gacggtggtc gacccgcgct gggtcgcccc ggtcaacccc acgctggtgg aggccgccgc
    18841 gtacttcaag cacgtgatca ccatcgagga cagcggacgc accggcggcg tgggcgcggc
    18901 gttcgggcag gccctggcgg acgccgggat cgacacgccc gtacggaact tcgggctgcc
    18961 gcgcgagttc ctcgaccacg gctcgcgggc ccaggtcctc gcccactgcg ggctgaccgc
    19021 cgacgccgtc accggcgcgg tgctgactcg gatgacctcg gaaaggacac tcacctcatg
    19081 accgccatcg cactcggaat gccggatgtt ccggtgaagc tcgccgaccg gagggtcagt
    19141 cggcagatcc aggtcggttc ggtggctgtc ggtggggatg cgccggtgtc ggtgcagtcg
    19201 atgacgacga cgcggacctc ggacatcggg gcgacgttgc agcagatcgc ggagctgacg
    19261 gcgtcggggt gtcagattgt gcgggtggcg tgcccgacgc aggatgacgc ggacgcgttg
    19321 tcgacgatcg cgcggaagtc gcagatcccg gtgatcgcgg atattcattt ccagcccaag
    19381 tacgtgttcg cggcgattga cgcggggtgt gcggcggtgc gggtgaatcc ggggaacatc
    19441 aagcagttcg acgacaaggt gaaggagatc gcgggggcgg cgtcggcggc ggggacgccg
    19501 atccgtatcg gggtgaacgc gggttcgctg gacgcgcggc tgctgaggaa gtacgggaag
    19561 gcgactccgg aggcgctggt ggagtcggcg ttgtgggagg cgtcgctgtt cgaggagcac
    19621 gggttccggg acatcaagat ctcggtgaag cacaacgatc cggtggtgat ggtcaatgcg
    19681 taccggctgc tggcggcccg gtgtgattat ccgctgcatc tgggggtgac ggaggcgggt
    19741 ccggcgttcc aggggacgat caagtcggcg gtggcgttcg gtgctctgct gagtgagggg
    19801 atcggggaca cgatccgggt gtcgctgtcg gcgccgccgg cggaggaggt gaaggtcggt
    19861 ctgcagattc tggagtcgct gaatctgaag cagcggcgtc tggagatcgt gtcgtgtccg
    19921 tcgtgcgggc gggcgcaggt ggatgtgtac aagctggcgg acgaggtgac ggcggggctg
    19981 gacgggatgg aggttccgtt gcgggtcgcg gtgatgggct gtgtggtgaa cggtccgggt
    20041 gaggcgcgtg aggcggatct gggtgtggcg tcgggcaacg gcaaggggca gatcttcgtc
    20101 aagggtgagg tgatcaagac ggtgcccgag tccaagatcg tcgagaccct catcgaagag
    20161 gcgctgaaga tcgccgcgga gatggaggcc aacggcgttc cctccggcga gccgctggtc
    20221 gtggcggggg tgtgagacgg ggacgccccg gggggatcga aagtggcgaa ggccactttc
    20281 gatctaccga tcacttcggc ggccaccacc ggtcatagag gcggagaaca ccacctgtga
    20341 ggggacaccg ccgacatgac cgaaaccgtg aagggccctg ccgcctactt cccgtcgatc
    20401 gagaggaagt acggccggcc ggtcgcggag tggaaggagc tgatccgttc ctcaccgctg
    20461 acgaagcaca tggaactggt ctcctggctc aagacggacc acgcgctggg ccacggccac
    20521 gcgaacgcgc tcgtggccca cacgctcgcg gaggacgccg ggaagtagcc gggccgggct
    20581 caccgaccgg cttccggcgc cccgcgggaa cggcgcgggc tcctcaccac ccgtgctccg
    20641 ccagggcccc cgagccctcc agatacccga ggagtccttc cttcgggtat tcgatgatgt
    20701 cctcgggaag ttcgtggacg ctgaaccact gaagggcgag gcatttcgcg ggctctctgt
    20761 tgacggggtc accggcccag tcggtggcct cgaagaagaa cccgatccgt tccacgctct
    20821 cactctgctt gtggtgcacg acatgcacca gtcacagccg cgcggggtcg acccgcacac
    20881 cggtctcctc catcaactcc cgcgcggcac cggcgctgat ggtctcgccc cggtcgagct
    20941 tgccggaagg catgtgccag cggccgtggc cgtaggggcc gccgcgctgg gagaagagga
    21001 gcttgtcccc gtcgcgtagg aggacatgcg tgtcgatgac gggctgcgcg gggtgcggat
    21061 tcatggtt
//
