LOCUS       NZ_CP048397            21074 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. S4.7 chromosome, complete genome.
ACCESSION   NZ_CP048397
VERSION     NZ_CP048397.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S4.7
  ORGANISM  Streptomyces sp. S4.7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.
  TITLE     Viennamycins: new lipopeptides produced by Streptomyces sp. S4.7
            isolated from the rhizosphere of Edelweiss (Leontopodium nivale
            subsp. alpinum)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2020) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.8x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010384365.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 10:27:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,027
            CDSs (total)                      :: 6,939
            Genes (coding)                    :: 6,650
            CDSs (with protein)               :: 6,650
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 289
            CDSs (without protein)            :: 289
            Pseudo Genes (ambiguous residues) :: 0 of 289
            Pseudo Genes (frameshifted)       :: 103 of 289
            Pseudo Genes (incomplete)         :: 223 of 289
            Pseudo Genes (internal stop)      :: 23 of 289
            Pseudo Genes (multiple problems)  :: 52 of 289
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:05:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1822010
            Orig. end                         :: 1843084
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048397.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zotchev Lab, University of
            Vienna, Austria.
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21074
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="7"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21074
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21074
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11074](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11074)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(522..1574)
                     /locus_tag="SSPS47_RS08025"
                     /old_locus_tag="SSPS47_08185"
     CDS             complement(522..1574)
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608056.1"
                     /locus_tag="SSPS47_RS08025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08185"
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_147872557.1"
                     /transl_table=11
                     /translation="MSSNRISDENLPSEQEPAHGEVERAEDPFADPGLPAHRPRIQDID
                     ERAAKRSERAVAFLFTLSMLATVGFIASFVVFPVDKIVYIWPFGHVSALNFSLGMTLGV
                     ALFAIGAGAIHWARTLMSDEEIVQERHPIEATPEVAAQAKRDFLIGSAESGFGRRKLIR
                     NTMFGALAMVPLSGIVLLRDLGPLPEDKLRKTFWKKGLLLINQNTSEPLRPEDVTVGSL
                     TFAQPEGLDEHNENFNNEIAKAALMIVRIQPEDIKDKRELEWSHDGIVAYSKICTHVGC
                     PISLYEQQTHHVLCPCHQSTFDLSDGARVIFGPAGHALPQLRIGVNGEGYLYALGDFDE
                     PVGPSFWERG"
     gene            complement(1571..2380)
                     /locus_tag="SSPS47_RS08030"
                     /old_locus_tag="SSPS47_08190"
     CDS             complement(1571..2380)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969636.1"
                     /locus_tag="SSPS47_RS08030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08190"
                     /product="c-type cytochrome"
                     /protein_id="WP_147872559.1"
                     /transl_table=11
                     /translation="MKKLSARRRHPLAAVVVLLLALAATGGLYAAFAPAGKAQADDTAQ
                     SLAIDEGKKLYAVGCASCHGVGGQGTSDGPSLTGVGAAAVDFQVGTGRMPAQQPGPQVP
                     KKKVIYDQKEIDQLAAYVASLGPGPSVPTAKQYNPEGADSANGGELFRSNCAQCHNFGG
                     EGGALTNGKYAPGLEGVSPKHLYEAMLTGPQNMPSFPDSTMPEQEKRDIIAYVDAVNGD
                     ESSNPGGLKLGGIGPVSEGLFSWIIGLGALIATAVWVAAHTAKAKKS"
     misc_feature    2365..2380
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.57"
                     /tool="antismash"
     misc_feature    complement(2367..2378)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.74"
                     /tool="antismash"
     gene            complement(2455..3075)
                     /locus_tag="SSPS47_RS08035"
                     /old_locus_tag="SSPS47_08195"
     CDS             complement(2455..3075)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060072.1"
                     /locus_tag="SSPS47_RS08035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08195"
                     /product="heme-copper oxidase subunit III"
                     /protein_id="WP_031231895.1"
                     /transl_table=11
                     /translation="MSVVATATTVETGHAHPTVNRPNLTSVGTIIWLSSELMFFAALFA
                     MYFTLRSVTGDAFWSEKADSLNIPFSAVNTTILVLSSLTCQLGVFAAERGDVKKLRSWF
                     VITFVMGAVFIGGQIFEYTELVKHEGLSLSSDAYGSAFYLTTGFHGLHVTGGLIAFLLV
                     LGRTYAAKRFTHEQATAAIVVSYYWHFVDVVWIGLFATIYLIK"
     gene            3304..3705
                     /locus_tag="SSPS47_RS08040"
                     /old_locus_tag="SSPS47_08200"
     CDS             3304..3705
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123917.1"
                     /locus_tag="SSPS47_RS08040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08200"
                     /product="hypothetical protein"
                     /protein_id="WP_164249815.1"
                     /transl_table=11
                     /translation="MQPTATVLVYSDNASTREQVRTAAGRRPAADLPPVEYIECATMPA
                     VLKQLDRGGVDACVFDGEATPVGGMGLCRQIKDEIFNSPPVLLLMGRPQDAWLATWSRA
                     ESAVTLPVDPVGFPDALAALLRTRLAVEA"
     gene            complement(3754..5013)
                     /locus_tag="SSPS47_RS08045"
                     /old_locus_tag="SSPS47_08205"
     CDS             complement(3754..5013)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012381265.1"
                     /locus_tag="SSPS47_RS08045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08205"
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_164249817.1"
                     /transl_table=11
                     /translation="MNHKPRFRTVLGCTLLVLSVGAVATGCGDTDRHPLSGKPYDAADQ
                     VSLNAPKGDAKANPDKPLEVVAKGGDGRITDVTVTDKAGHHLAGELAADGARWHSTAPL
                     AAGARYTVKVSTEDEDGAPGSRTLDFETSSVQRNLNVKFGPQAGKYGVGQPITAELSAP
                     VKEKEARAVVERGLKVRSSPAAEGSWYWVDDKKLHFRPKEYWPANATVSVTSTLDGIKV
                     GNKLYGGPVKPLKITTGDRLEAVADAGTHHMTVLRNGEEIRTIPVTTGKPGFSTRNGTK
                     VVLEKQQFVRMRGTSVGIAAGSSESYDLPVYWATRVTWSGEYVHAAPWSVGSQGSANVS
                     HGCVGMSTDNAEWFFGTVRQGDIVKVVNSGGEDMDPFGNGFGDWNLDWAKWRQGSALVG
                     GTGAGDGTGPVEAARLRPQV"
     gene            complement(5144..5542)
                     /locus_tag="SSPS47_RS08050"
                     /old_locus_tag="SSPS47_08210"
     CDS             complement(5144..5542)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003947651.1"
                     /locus_tag="SSPS47_RS08050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08210"
                     /product="cytochrome c oxidase subunit 4"
                     /protein_id="WP_147872564.1"
                     /transl_table=11
                     /translation="MKVQGWMFLWLSLFILVVAAVYGVWSKEPVGTTALFLAFGLSLMI
                     GFYLAFTARRVDAMAQDNKEADVADEAGEVGFFSPHSWQPLSLAIGGALAFLSVAIGWW
                     LLFFSFPIILIGLWGWVFEYYTGENQNQ"
     gene            complement(5539..7278)
                     /gene="ctaD"
                     /locus_tag="SSPS47_RS08055"
                     /old_locus_tag="SSPS47_08215"
     CDS             complement(5539..7278)
                     /EC_number="7.1.1.9"
                     /GO_function="GO:0004129 - cytochrome-c oxidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ctaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010057802.1"
                     /locus_tag="SSPS47_RS08055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08215"
                     /product="cytochrome c oxidase subunit I"
                     /protein_id="WP_147872566.1"
                     /transl_table=11
                     /translation="MSILNEPKGAAAAADDSYENELPVRRKQPGAVVVKWLTTTDHKTI
                     GTLYLVTSFVFFCIGGVLALFMRAELARPGTQIMSNEQFNQAFTMHGTIMLLMFATPLF
                     AGFANWIMPLQIGAPDVAFPRLNMFAYWLYLFGSIIAVAGFITPQGAADFGWFAYSPLS
                     DAVRSPGIGADLWIMGLAFSGFGTILGSVNFITTIICMRAPGMTMFRMPIFCWNVLLTG
                     VLVLLAFPVLAAALFALEADRKFGAHIFDAANGGALLWQHLFWFFGHPEVYIIALPFFG
                     IVSEIIPVFSRKPMFGYIGLVAATIAIAGLSVTVWAHHMYVTGGVLLPFFSFMTFLIAV
                     PTGVKFFNWIGTMWKGSLSFETPMLWTIGFLVTFTFGGLTGVILASPPMDFHVSDSYFV
                     VAHFHYVVFGTVVFAMFAGFHFWWPKMTGKMLDERLGKITFWTLFIGFHGTFLVQHWLG
                     AEGMPRRYADYLAADGFTALNTISTISSFLLGLSVLPFFYNVWKTAKYGKKVEVDDPWG
                     YGRSLEWATSCPPPRHNFTTLPRIRSESPAFDLHHPEIAALEHLENDGQKDAALLGGKE
                     VGK"
     gene            complement(7275..8237)
                     /gene="coxB"
                     /locus_tag="SSPS47_RS08060"
                     /old_locus_tag="SSPS47_08220"
     CDS             complement(7275..8237)
                     /EC_number="7.1.1.9"
                     /GO_function="GO:0004129 - cytochrome-c oxidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="coxB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104385.1"
                     /locus_tag="SSPS47_RS08060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08220"
                     /product="cytochrome c oxidase subunit II"
                     /protein_id="WP_147872568.1"
                     /transl_table=11
                     /translation="MSPNGSDRSSRRPMRRKLPQVLTAGLILATASGCTYKDFPRLGMP
                     TPVTEEAPRILSLWQGSWAAALVTGILVWGLIVWSVIFHRRSRTKVEVPPQTRYNMPIE
                     ALYTVVPLIIVSVLFYFTARDESKLLSLDDKPTHTVNVVGYQWSWGFNYVENVDGDAAT
                     GTGVPKELGDIPQKFQDDFPAGAEGVYDAGIPGTRNPQNGNPGPTLWLPKGEKVRFVLT
                     SRDVIHSFWVVPFLMKQDVIPGHTNAFEVTPNREGTFMGKCAELCGVDHSRMLFNVKVV
                     SPERYQQHLKELAEKGQTGYIPSGIGLTDPARNAEKKQL"
     misc_feature    8318..8331
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     gene            8514..9902
                     /locus_tag="SSPS47_RS08065"
                     /old_locus_tag="SSPS47_08225"
     CDS             8514..9902
                     /NRPS_PKS="Domain: Aminotran_5 (2-360). E-value: 2.6e-48.
                     Score: 156.7. Matches aSDomain:
                     nrpspksdomains_SSPS47_RS08065_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010471125.1"
                     /locus_tag="SSPS47_RS08065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08225"
                     /product="cysteine desulfurase/sulfurtransferase TusA
                     family protein"
                     /protein_id="WP_164249819.1"
                     /sec_met_domain="Aminotran_5 (E-value: 9.9e-43, bitscore:
                     145.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYFDSASSAPLHPVALEALRAALDEGWADPARLYREGRRARLLL
                     DAAREAAAEAVGCRPDELVFTPSGTYAVHSGIAGSLAGRRRVGAHAVVSAVEHSSVLHA
                     AHTRVVEGDGPAVTEVPVDRTGAVSPSAYAAALRPDTALACLQSANHEVGTVQPVEAVA
                     EACRAAGVPLLVDAAQSLGWGPVDGAWSLLTASAHKWGGPAGVGLLAVRKGVRFAPQGP
                     VDERESGRVPGFGNLPAIVAAAASLRAVRSEAEREAARLRVLVDRIRARVPESVPDVEV
                     VGDPVHRLPHLVTFSCLYVDGETLLHELDRAEFSVSSGSSCTSSTLTPSHVLRAMGVLS
                     EGNVRISLPSGTAEAEVERFLEVLPGVVAGVRERLGVPATAREGGGETAPDAASVVVDA
                     LGRLCPIPVIELAKVIGDVPVGGTVTVLSDDEAARLDIPAWCEMRGHEYGGRSGTAFLV
                     RRLV"
     aSDomain        8520..9593
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SSPS47_RS08065_Aminotran_5.1"
                     /evalue="2.60E-48"
                     /label="SSPS47_RS08065_Aminotran_5.1"
                     /locus_tag="SSPS47_RS08065"
                     /protein_end="360"
                     /protein_start="2"
                     /score="156.7"
                     /tool="antismash"
                     /translation="YFDSASSAPLHPVALEALRAALDEGWADPARLYREGRRARLLLDA
                     AREAAAEAVGCRPDELVFTPSGTYAVHSGIAGSLAGRRRVGAHAVVSAVEHSSVLHAAH
                     TRVVEGDGPAVTEVPVDRTGAVSPSAYAAALRPDTALACLQSANHEVGTVQPVEAVAEA
                     CRAAGVPLLVDAAQSLGWGPVDGAWSLLTASAHKWGGPAGVGLLAVRKGVRFAPQGPVD
                     ERESGRVPGFGNLPAIVAAAASLRAVRSEAEREAARLRVLVDRIRARVPESVPDVEVVG
                     DPVHRLPHLVTFSCLYVDGETLLHELDRAEFSVSSGSSCTSSTLTPSHVLRAMGVLSEG
                     NVRISLPSGTAEAEVERF"
     gene            complement(10001..11074)
                     /locus_tag="SSPS47_RS08070"
                     /old_locus_tag="SSPS47_08230"
     CDS             complement(10001..11074)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840879.1"
                     /locus_tag="SSPS47_RS08070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08230"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_239064808.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.4e-41, bitscore:
                     139.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEVTARSDNGVLTADSARRTTRHLLERVEHRLRDFLTAENEIW
                     TAVDKRAPVPVGAVADLIDSGGKRLRPAFCVMGYLAAGGAPDAPGVVPAAAALEMLHAC
                     ALIHDDVMDAAGQRRGAPTVHMKHSAEHRERGWQGEARRFGESVAILAGDLALIYSDRL
                     MAEAPPALVPVWSELRAELIIGQYMDVASAAEFSVDPELSRWIALAKSGRYTIHRPLVV
                     GATLAGATGLAAAFEEYGGAVGEAFQLRDDLLGAFGDPTETGKPAGLDFSQHKMTLLLG
                     WAMQRDERVRDLVTTPGHDADELRDLLVATGVPDDVEKHIDELVQRGRAALDAAPMDQV
                     WRDELGAMALRVAYRKT"
     misc_feature    11133..11151
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    complement(11208..11223)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            11305..12276
                     /locus_tag="SSPS47_RS08075"
                     /old_locus_tag="SSPS47_08235"
     CDS             11305..12276
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013226.4"
                     /locus_tag="SSPS47_RS08075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08235"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_343234869.1"
                     /transl_table=11
                     /translation="METKPAQISGAASKTSRTIVLRGLLRLSKIRVFQHYFGLALAWLL
                     LSPEALQRPGATTAMLLFLLGSVAIVACACASDDIAGFRNGSDLMNYQSDEQLRDIHAK
                     PLLTGAVTERQALTFAVGSGFLAVPAGAAAFWALDWDAPFSAYALYLLGFAFSVQYSVG
                     LRVSYRRGGGETLLCFSTAAGLLAPFLAVNRDWTWPAVAQALLLGLWLVMVSSYSNVND
                     VAGDRMAGRRTLAVTTGRTVQNAAMASFFLLSAGLLTALAMTGGWPGWLLLTALPATVL
                     HAAQLYHGPVRGQWLRARKLGLIAYNLGFAGIAVPTFFALHR"
     misc_feature    11353..11366
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.43"
                     /tool="antismash"
     misc_feature    11374..11376
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12586..12966
                     /locus_tag="SSPS47_RS08080"
     CDS             12586..12966
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SSPS47_RS08080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164249823.1"
                     /transl_table=11
                     /translation="MLIAWSSSVAEEKGTPAPGSSVRRLTHFLLTHLHWLATSTEAVVF
                     ADEIENLTTEARRTIDPAPEARLITLGRCVEPDCAEIITAAAPGRRILNSRSISCAAGH
                     SWEVHEWFLLQSRIEQKKGVSA"
     gene            12963..13145
                     /locus_tag="SSPS47_RS08085"
                     /old_locus_tag="SSPS47_08245"
     CDS             12963..13145
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554463.1"
                     /locus_tag="SSPS47_RS08085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08245"
                     /product="hypothetical protein"
                     /protein_id="WP_164249825.1"
                     /transl_table=11
                     /translation="MTRPPRHRRVPTKAAALAVGVPEATIRQWVRRGKLTRYGTPGRAE
                     FDIAELTVIAKGPDR"
     gene            complement(13236..14351)
                     /locus_tag="SSPS47_RS08090"
                     /old_locus_tag="SSPS47_08250"
     CDS             complement(13236..14351)
                     /GO_function="GO:0003856 - 3-dehydroquinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014064.4"
                     /locus_tag="SSPS47_RS08090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08250"
                     /product="3-dehydroquinate synthase II"
                     /protein_id="WP_164249827.1"
                     /transl_table=11
                     /translation="MDTEQELWADVTGLGPDDTAAALAHARSSAATTVLLRPDQLDGWE
                     PLERITLAALVDADNAPAALDDQRVGILLVEAPAQLDTVRALAGGRPVGVRCEIVDGDT
                     MNVAADLCGRADVLVAAFIDETNIPLELLLARAQDGTTRVLKELLSSAETASVAGVLES
                     GPAGLVVRGDQLADIDRVGEALRLRRQVRKDLVPLEVVRAEPIGMGYRGCVDTATLFGE
                     DEGMIVGSTSSGGILVCAEVHYLPYMNLRPFRVNAGAVHSYVFGADTTAYITDLAAGER
                     SHAVSADGTFREVVVGRVKVELRPLRLIEATYGDVKVNVFLQDDWHVRVMSAEGKPLNL
                     TDVVPGTELLGHVTEPGRHVGIKVAERISEF"
     gene            complement(14433..15191)
                     /locus_tag="SSPS47_RS08095"
                     /old_locus_tag="SSPS47_08255"
     CDS             complement(14433..15191)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013916.4"
                     /locus_tag="SSPS47_RS08095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08255"
                     /product="fructose-bisphosphate aldolase"
                     /protein_id="WP_164249829.1"
                     /transl_table=11
                     /translation="MTAVNGKERRLRRLIAEDGRTLLVALDHSVTTGVVGGLTNMGSVM
                     RSVVSGGADGIVAHRGSAAREMPVQRDTAMIVHLSGNTALSPQSELKATVCEPETAAAM
                     GADAVSAHITLGCGHREDRDALVGLGAVARSCDRLGMPLLVMTYIRTEATDIGPDVLHA
                     SRIAAELGADIVKAAHPGEQYLTDLAAQVPVPVVIAGGGPDGSWDAFLNSAKNAIGAGI
                     AGLCVGRRVFGSVDPARATAELRGVVHGSG"
     gene            complement(15305..15850)
                     /locus_tag="SSPS47_RS08100"
                     /old_locus_tag="SSPS47_08260"
     CDS             complement(15305..15850)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015155.4"
                     /locus_tag="SSPS47_RS08100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08260"
                     /product="MMPL family transporter"
                     /protein_id="WP_164249831.1"
                     /transl_table=11
                     /translation="MATFGALVWIFQDGHLAGLLGGFTVTGDIAATVPVMLFALSFGLA
                     MDYQIFLLARIREEYEITGDGSAAVARGLERIGRIVTAAAVLISVVFLAFAVSDITLSK
                     AYGIGLPLAVLMDATLIRGLLLPALMRLGGRATWRAPAPLRRVHARFGLKEYDGAPDAE
                     HLVPVTAAREGVSAPDRM"
     misc_feature    15855..15870
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            complement(15951..16925)
                     /locus_tag="SSPS47_RS08105"
                     /old_locus_tag="SSPS47_08265"
     CDS             complement(15951..16925)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115841.1"
                     /locus_tag="SSPS47_RS08105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08265"
                     /product="carbohydrate kinase family protein"
                     /protein_id="WP_164249833.1"
                     /transl_table=11
                     /translation="MRIAVTGSIATDHLMTFPGRFADQLVGDQLHTVSLSFLVDNLDVR
                     RGGVGANICFGMGQLGTAPILVGAVGPDFDEYRAWLDRHGVDTASVRVSEVLHTARFVC
                     TTDADHNQIGSFYTGAMSEARQIELKSVADRVGGLDLVLIGADDPEAMLRHTEECRTRS
                     IPFAADFSQQIARMEGDEIRLLLDGATYLFSNEYEKGLIESKTGWTDAEILSRVGHRVT
                     TLGSRGVRIERVGDDPIEVGCAEETAKVDPTGVGDAFRAGFLSGLSWGVGLERAAQVGC
                     MVATLVIETLGTQEYTLRRNNFMDRFTKAYGDEAATEVRAHLR"
     misc_feature    16954..16974
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.62"
                     /tool="antismash"
     gene            17056..17268
                     /locus_tag="SSPS47_RS08110"
                     /old_locus_tag="SSPS47_08270"
     CDS             17056..17268
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608066.1"
                     /locus_tag="SSPS47_RS08110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08270"
                     /product="hypothetical protein"
                     /protein_id="WP_164249834.1"
                     /transl_table=11
                     /translation="MRNHTVPRERSVRESDTSLAELRGDCARMAPHWVRPATAAPVPVP
                     PSLIHGVTVPSASARLIDGMSEYGD"
     gene            17353..18858
                     /locus_tag="SSPS47_RS08115"
                     /old_locus_tag="SSPS47_08275"
     CDS             17353..18858
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005318561.1"
                     /locus_tag="SSPS47_RS08115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08275"
                     /product="hypothetical protein"
                     /protein_id="WP_164249836.1"
                     /transl_table=11
                     /translation="MTSTERPQDGDGERNGWRRSPFAVVSVVAAVLLAGGGGAYFATTS
                     SEGGGDGKSAARGAGDLDPPPLALGADAGGGAGRNPGLGIAPGEPSPYGVEYRASGTLP
                     EGPDSAAVHRPEGSVAAADVARLAKALGVSGTPERSGTAWKVGGHKDGSGPLLTVDQQA
                     PGDWTFGRFGPAPGGDDCLKGKECPSGDGGGSNPVVPGDGAGPVSERAAKKAAAPVLKA
                     LGQEDAALDAGQLMGAVRVVNAAPVVAGLPTYGWSTGIQIGADGQVVAGSGKLKEPAKG
                     AEYPVVSAVEALKLLNGAAGDRGTSGIGGCASAVPQKDGREPAAPCEPGGTGVKPTQVP
                     VGKAVFGLASRQVEGRAALVPSWWFEVAGAGDGPASFVTRTAVLPEYLTRGGGSGDGTD
                     AGPGNDDGAVRQDSDEPGFPVETYSADGSTLSVRFRGAPCGEYSVRAEESGSVVKVEVV
                     DSAPRRVCIAISKALTEKVTLDKQLGDRKVVDAVTGDAVPLRK"
     gene            complement(18954..19310)
                     /locus_tag="SSPS47_RS08120"
                     /old_locus_tag="SSPS47_08280"
     CDS             complement(18954..19310)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008738845.1"
                     /locus_tag="SSPS47_RS08120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08280"
                     /product="iron-sulfur cluster assembly accessory protein"
                     /protein_id="WP_078077727.1"
                     /transl_table=11
                     /translation="MSVSDETTTVSDGILLSDAAAGKVKALLDQEGRDDLALRVAVQPG
                     GCSGLRYQLFFDERSLDGDVVKDFDGVKVVTDRMSAPYLGGASIDFVDTIEKQGFTIDN
                     PNASGSCACGDSFN"
     misc_feature    complement(19490..19510)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.37"
                     /tool="antismash"
     misc_feature    complement(19513..19533)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.72"
                     /tool="antismash"
     misc_feature    complement(19518..19533)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    19547..19567
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 25.17"
                     /tool="antismash"
     gene            19600..20787
                     /gene="nadA"
                     /locus_tag="SSPS47_RS08125"
                     /old_locus_tag="SSPS47_08285"
     CDS             19600..20787
                     /EC_number="2.5.1.72"
                     /GO_function="GO:0008987 - quinolinate synthetase A
                     activity [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nadA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130009.1"
                     /locus_tag="SSPS47_RS08125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_08285"
                     /product="quinolinate synthase NadA"
                     /protein_id="WP_164249838.1"
                     /transl_table=11
                     /translation="MTTAQARQDLAVQPTPLALLLLGREADTRSERGVDCPGDLPSPSD
                     PDLVERARAAKEKLGEKVFILGHHYQRDEVIQFADVTGDSFKLAKDAAARPEAEYIVFC
                     GVHFMAESADILTADDQKVVLPDLAAGCSMADMATAEQVAECWDVLTEAGIAERVVPVS
                     YMNSSADIKAFTGKHGGTICTSSNAERALDWAFEQGDKVLFLPDQHLGRNTAVRDLGLS
                     LEDCVLYNPHKPNGGLTAEELRNAKMILWRGHCSVHGRFSLDSVNEVRERIPGVNVLVH
                     PECKHEVVSAADYVGSTEYIIKMLQQAPAGSKWAIGTELNLVQRLANRFAADDKEIVFL
                     DRTVCFCSTMNRIDLPHLVWTLESLAEGKDINRIQVEKETADFAQLALERMLALP"
     misc_feature    complement(21012..21021)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 ggtgcccgac agcagatcgt ccggaagcga gtaaccggtg agaccggtga acagcgacag
       61 gaagaacagc aggaagccga acacccagtt gatctcacgg ggcttgcgga acgcgcccgt
      121 gaagaagaca cgcatcatgt gcacgaacat cgcggccacg aagatcagcg cggcccagtg
      181 gtggatctgc cggatcagca gaccaccgcg gacgtcgaag ctgatgtcca gggtcgaggc
      241 gtacgcctcg gtcatccgga caccctgcat cggtacgtaa ctgccctcgt acacgacctc
      301 gttcatgctc gggtggaaga acagcgtcag atacacaccc gtgaggatga tgacgacgaa
      361 gctccacagg gcgacctcgc ccagcatgaa cgaccagtgg tccggaaaga ccttccgcag
      421 catgcccttg gccgcgccgt agatcccgag gcggccgtcg gcccagtcgg cgacccgctc
      481 tccagcgggt gccttgcggt tcttttcgtc agtcgcagta ctcatccgcg ctcccagaag
      541 gacggaccga cgggctcgtc gaaatcgccg agcgcgtaga ggtaaccctc gccgttcaca
      601 ccgatccgca gctgcggaag cgcgtgaccg gccgggccga agatgacgcg ggcgccgtcg
      661 gagaggtcga aggtggactg gtggcacggg cagagcacgt ggtgcgtctg ctgctcatac
      721 aggctgatgg gacagccgac atgggtgcag atcttggagt acgcgacgat gccgtcgtgc
      781 gaccactcga gttcgcgctt gtccttgatg tcttcgggct gaatgcgaac gatcatgaga
      841 gccgccttgg cgatctcatt gttgaagttc tcattgtgct cgtccagccc ctcgggctgg
      901 gcgaaggtca gcgaccccac ggtgacgtcc tcgggacgca gcggctcgct cgtgttctgg
      961 ttgatgagca gcaagccctt cttccagaac gtcttgcgga gcttgtcctc aggcagcggg
     1021 ccgaggtcac gcagcaggac gatgccggag agcggcacca tggccagcgc accgaacatc
     1081 gtgttgcgga tcagcttgcg gcgcccgaag ccggactccg ccgagccgat caggaagtcc
     1141 ctcttcgcct gcgcggcgac ctcgggggtc gcctcgatcg ggtggcgctc ctggacgatc
     1201 tcctcgtcgc tcatcagcgt gcgcgcccag tggatcgcac ccgcgccgat ggcgaagagg
     1261 gcgactccga gcgtcattcc cagcgagaag ttgagcgcgc tcacgtggcc gaacggccag
     1321 atgtacacga tcttgtcgac ggggaagacg acgaacgagg cgatgaagcc gaccgtggcc
     1381 agcatcgaca gcgtgaagag gaaggccacc gcgcgctcgg agcgcttggc cgcccgctcg
     1441 tcgatgtcct ggatgcgcgg ccggtgggcc ggcagtccgg ggtcggcgaa ggggtcctcc
     1501 gcgcgctcca cctcgccgtg tgccggctcc tgctcactcg gcaggttctc gtctgaaatc
     1561 cggttgctac tcatgacttc ttggccttag cggtgtgcgc cgcgacccag acggcagttg
     1621 cgatcagtgc gcccagaccg atgatccagg agaacaggcc ctcactgacg ggcccgatgc
     1681 caccgagctt gagtccgccg gggttcgagg actcgtcacc gttcaccgca tcgacgtacg
     1741 cgatgatgtc ccgcttctcc tgctcgggca tcgtcgagtc ggggaacgac ggcatgttct
     1801 gcggaccggt cagcattgcc tcgtacaggt gcttgggcga taccccttca agccccggcg
     1861 catacttgcc gttcgtcaga gcgccgcctt caccgccgaa gttgtggcac tgggcgcagt
     1921 tggagcggaa cagctcaccg ccgttggcgg agtccgcgcc ttccgggttg tactgcttgg
     1981 ctgtcgggac cgagggcccg gggccgagcg aggcgacgta cgccgcgagt tggtcgatct
     2041 ccttctggtc gtagatgacc ttcttcttcg gaacctgcgg gccgggctgc tgcgccggca
     2101 tccggccggt gccgacctgg aagtccacgg cggcggcgcc gacgccggtc agcgacggac
     2161 cgtcggacgt gccctgaccg ccgacgccgt ggcagctggc gcagcccacg gcatacagct
     2221 tcttgccctc gtcgatggcg agggactggg cggtgtcgtc tgcctgtgcc ttgcccgcgg
     2281 gcgcgaacgc ggcgtacagc cccccggtgg ccgccagcgc gaggagtagg acgacgaccg
     2341 ccgccaacgg atggcgtcgt cgtgcggaga gctttttcac ggattacccc ggtgtcagga
     2401 tcttctgcgt cggtgcttct ggactgtgcg cgagcgcgtc gggcgcgtgg cccgctactt
     2461 gatcagatag atcgtggcga agaggccgat ccagacgaca tcgacgaagt gccagtaata
     2521 ggacacgacg atggcggcgg ttgcctgctc gtgggtgaac ctcttggccg cgtacgttct
     2581 gccgagaacc agcaggaagg cgatgagacc gcctgtcacg tgcagaccat ggaagccggt
     2641 ggtcagatag aacgcggagc cgtacgcgtc ggacgagagc gagaggccct cgtgcttcac
     2701 gagctccgtg tactcgaaga tctgaccgcc gatgaagacc gcacccatca cgaacgtgat
     2761 cacgaaccac gagcggagct tcttcacatc gccccgctcg gcggcgaaga cgccgagctg
     2821 gcaggtgagt gaggagagca ccaggatcgt ggtgttcacc gcggagaacg ggatgttcag
     2881 cgaatcggcc ttctccgacc agaacgcatc ccctgtcacc gaccgcaggg tgaagtacat
     2941 cgcgaagagg gccgcgaaga acatcagctc ggagctcaac cagatgatcg ttccgacact
     3001 ggtgaggttc ggccgattga ccgtcgggtg cgcgtgcccg gtttctactg tcgttgctgt
     3061 cgccacgacc gacattatgt cggtcgctta tcccgccctc actcccgggg gtcccattcg
     3121 gagtgtcagc cacttcggac gggacccgga gagggaccga acggcccatc gcgggcgggc
     3181 cgggacccgt gctgacatgg tgtgcgacgg agtagcatcc gcgcagcggg tctcggcgcc
     3241 caggctctga agccctcgca gacgcggatg tgcggatgtc acgacggatg tcacggagga
     3301 acaatgcagc cgactgccac ggtcctggtc tacagcgaca acgcgagcac ccgcgagcag
     3361 gtgcggacgg ccgcgggacg caggccggcc gccgatctgc cgccggtcga gtacatcgag
     3421 tgcgccacga tgcccgccgt gctgaagcag ctcgacaggg gcggcgtgga cgcctgtgtg
     3481 ttcgacggtg aggccacgcc cgtcggcggc atgggcctgt gccggcagat caaggacgag
     3541 atcttcaatt ccccgccggt gctgctcctg atgggccgcc cgcaggacgc ctggctggcc
     3601 acctggagcc gcgcggagtc cgccgtgacg ctgccggtgg acccggtcgg cttccccgac
     3661 gccctggcgg cgctgctgcg caccaggctc gccgtggaag cctgacggtt ccaccggcag
     3721 ggggccggtc gcccggcccc cgcgtcgcgt gtgtcagacc tgcgggcgca gccgggccgc
     3781 ctcgaccggg ccggtgccgt ccccggcccc ggtgccgccg accagtgcgc tgccctggcg
     3841 ccacttggcc cagtccaggt tccagtcgcc gaagccgttg ccgaacgggt ccatgtcctc
     3901 gccgccgctg ttgacgacct tgacgatgtc gccctggcgg acggtgccga agaaccactc
     3961 ggcgttgtcg gtcgacatgc cgacacagcc gtggctgacg ttcgcggacc cctgtgagcc
     4021 gacggaccac ggggcggcgt gcacgtactc accgctccag gtgacccgcg tcgcccagta
     4081 gacgggcagg tcgtacgact cgctgctgcc ggccgcgatg ccgacgctgg tgccccgcat
     4141 ccgtacgaac tgctgcttct ccagcacgac cttggtgccg ttacgggtcg agaagccggg
     4201 cttgccggtg gtcaccggga tggttctgat ctcctcgccg ttgcgcagga ccgtcatgtg
     4261 gtgcgtgccg gcgtcggcga cggcttcgag gcggtcgccc gtggtgatct tgaggggctt
     4321 caccgggccg ccgtacagct tgttgccgac ctttatgccg tcgagggtgc tggtgacgct
     4381 cacggtcgcg ttggcgggcc agtactcctt gggccggaag tgcagcttct tgtcgtcgac
     4441 ccagtaccag gagccctcgg cggcggggct ggagcggacc ttgagaccgc gttcgacgac
     4501 ggccctggcc tctttctcct tgacgggcgc gctcagctcc gcggtgatgg gctggccgac
     4561 gccgtacttg cccgcctgcg ggccgaactt gacgttcagg ttgcgttgca ccgaggacgt
     4621 ctcgaagtcg agcgtacggc tgccgggagc gccgtcctcg tcctccgtgg agaccttgac
     4681 ggtgtagcgc gcaccggcgg ccagtggggc cgtggagtgc cagcgggcgc cgtccgcggc
     4741 cagctcgccc gcgaggtggt ggccggcctt gtcggtgacg gtcacatcgg tgatccgccc
     4801 gtcgccgccc ttggcgacga cttccagcgg cttgtcgggg ttcgccttgg cgtcgccctt
     4861 gggcgcgttg agggagacct ggtcggctgc gtcgtagggc ttgccggaca gcgggtggcg
     4921 atccgtatcg ccacagccgg tcgccacggc ccccacggac aggaccagca gcgtgcagcc
     4981 gagaacggtg cgaaagcgcg gcttgtggtt cataagcaca cgttaagaag attatccggt
     5041 tacggcgcgc tgtgtgactg caaacgaggg gcccggatcc tcctcagggg tgaggaagat
     5101 ccgggccctt gtcccgcgta acggcacgtc gcggccgttg tgcctactgg ttctggttct
     5161 cacccgtgta gtactcgaag acccagcccc acaggccgat caggatgatc gggaaggaga
     5221 agaacagcag ccaccagccg atggccacgg agaggaacgc gagcgctccg ccgatggcca
     5281 gggagagcgg ctgccagctg tgcggggaga agaatccgac ctcgccggcc tcgtccgcga
     5341 cgtcggcctc cttgttgtcc tgcgccatcg cgtcgacccg ccgggccgtg aaggccaggt
     5401 agaagccgat catgagactc aggccgaagg ccaggaagag tgcggtggtg ccgaccggct
     5461 ccttcgacca gacgccgtag acagcggcga cgacgaggat gaagaggctc agccagagga
     5521 acatccagcc ttggaccttc acttgccgac ctccttgcca ccgagcagag cggcgtcctt
     5581 ctgtccgtcg ttctcaaggt gttcgagcgc cgcgatctcc gggtggtgca ggtcgaacgc
     5641 cggggattcg gagcggatgc gcggcagcgt ggtgaagttg tgccgcgggg gcgggcacga
     5701 agtcgcccat tcgagtgaac ggccgtagcc ccacgggtcg tccacctcga ccttcttccc
     5761 gtacttggcc gttttccaga cgttgtagaa gaacggcagg accgacaggc ccagcaggaa
     5821 cgagctgatc gtcgagatgg tgttcagcgc ggtgaagccg tcggcggcca gatagtccgc
     5881 gtaacggcgc ggcatgccct ccgcgcccag ccagtgctgg accaggaacg tgccgtggaa
     5941 tccgatgaac agcgtccaga aggtgatctt cccgagccgt tcgtcgagca tcttgcccgt
     6001 catcttcggc caccagaagt ggaagccggc gaacatcgcg aacaccaccg tgccgaagac
     6061 gacgtagtgg aagtgcgcga cgacgaagta cgagtcggag acgtggaagt ccatcggcgg
     6121 cgaggccagg atgacgcccg tcaggccacc gaaggtgaag gtgaccagga agccgatggt
     6181 ccagagcatc ggtgtctcga aggacagcga ccccttccac atcgtgccga tccagttgaa
     6241 gaacttcaca cccgttggca ccgcgatcag gaatgtcatg aacgagaaga acggtagtag
     6301 tacaccgccc gtcacataca tgtggtgcgc ccacaccgtc accgagaggc cggcgatggc
     6361 gatcgtcgcc gcgaccagac cgatgtaacc gaacatcggc ttccggctga acaccggaat
     6421 gatctcggag acgatcccga agaacggcag ggcgatgatg tacacctctg gatgcccgaa
     6481 gaaccagaac aggtgctgcc agagcagggc gccgccgttc gcggcgtcga agatgtgcgc
     6541 accgaacttc cggtcggcct ccagcgcgaa gagcgcggcg gccagcaccg ggaaggcgag
     6601 caggaccagc acaccggtca gcagcacgtt ccagcagaag atcggcatcc ggaacatcgt
     6661 catgccgggc gcgcgcatgc agatgatcgt ggtgatgaag ttgaccgaac cgaggatcgt
     6721 gccgaagccg gagaaggcca ggcccatgat ccacaggtcg gcgccgatgc ccggcgaacg
     6781 gaccgcgtcc gacagcgggg agtacgcgaa ccagccgaag tcggccgcgc cctgcggggt
     6841 gatgaaaccg gccaccgcga tgatcgagcc gaacaggtag agccagtagg cgaacatgtt
     6901 cagccgcggg aacgccacgt cgggcgcgcc gatctggagc ggcatgatcc agttcgcgaa
     6961 tccggcgaac agcggcgtcg cgaacatcag cagcatgatc gtgccgtgca tcgtgaacgc
     7021 ctggttgaac tgctcgttcg acatgatctg cgtgccggga cgggccagct cggcgcgcat
     7081 gaagagcgcg agcacaccac cgatgcagaa gaagacgaac gacgtgacca gatagagcgt
     7141 gccgatcgtc ttgtgatcgg tggtggtcag ccacttgacg acgacagcgc cgggctgctt
     7201 gcgccgtacc ggcagctcgt tctcgtacga gtcgtcagct gctgcggcgg cacccttggg
     7261 ttcgttgagg atgctcacag ttgtttcttc tccgcattcc tggccgggtc cgtcagtccg
     7321 atgcccgacg ggatgtagcc ggtctgcccc ttctcggcca gctccttcag gtgctgctgg
     7381 tagcgctccg gggagacgac cttgacgttg aagagcatcc gggagtggtc cacgccgcag
     7441 agttcggcgc acttgcccat gaaggtgccc tcccggttgg gggtcacctc gaaggcgttg
     7501 gtgtgccccg gaatgacgtc ctgcttcatc aggaacggca cgacccagaa ggagtggatg
     7561 acgtcacggg acgtcagcac gaaccggacc ttctcgccct tcggcagcca cagggtcgga
     7621 cccgggttgc cgttctgggg attgcgcgtg cccgggattc cggcgtcgta gacgccttcg
     7681 gcgccggccg ggaagtcgtc ctggaacttc tgcgggatgt caccgagttc cttgggaacc
     7741 ccggtgcccg tggcggcgtc gccgtccacg ttctccacgt agttgaagcc ccagctccac
     7801 tggtagccca ccacgttcac ggtgtgggtg ggcttgtcgt cgagagacag gagcttcgac
     7861 tcgtcacgcg cggtgaagta gaagagcacc gagacgatga tgagcggaac gaccgtgtac
     7921 agggcctcga tgggcatgtt gtaacgggtc tgtggaggaa cctccacctt ggtgcggctg
     7981 cgccggtgga agatgacgct ccacacgatc agcccccaca ccaggatgcc cgtgacgagc
     8041 gctgccgccc acgagccctg ccagagggag aggattctgg gggcctcctc ggtcaccgga
     8101 gtgggcattc cgaggcgggg gaaatccttg tacgtgcaac cggaggcggt cgcgaggatc
     8161 aggcccgcag tcagcacctg cggcagcttc cgccgcatcg ggcgccgcga cgagcggtcg
     8221 gagccgttgg gactcacgta gcgccttccc gagagtctcg cccgcacagc cggctgcggc
     8281 cgtcacggtc ggcgccggcc cgacgcgggc aggggtttgg atgtttatgc ggaccaaacc
     8341 ctactggacg caatttgggg tcgcgcatgg agggtgccca acgcgccgcc cggggccccg
     8401 aaggggtgga accgccggct ccggacactt ccgactcccc cttcggccgc tgtcgtcgcc
     8461 ccggcgatcg ggggcgccgt ccggggggtc cgggcaaggc ttagcgtggt ggcgtggcct
     8521 acttcgactc cgcgtcctcc gcaccgctgc accccgtcgc acttgaggcc ctgcgcgccg
     8581 ccctggacga gggctgggcc gatccggcca ggctgtaccg ggaggggcgg cgggccaggc
     8641 tgctgctgga cgccgcgcgc gaggccgccg ccgaggccgt cgggtgccga cccgacgaac
     8701 tggtcttcac tccttcgggg acgtacgcgg tccactccgg catcgccgga tcgctcgcgg
     8761 gccgtcggcg tgtcggcgcc catgcggtgg tctcggcggt cgaacactcg tcggtgcttc
     8821 atgccgccca cacgcgggtc gtcgaagggg acggtccggc ggtgacggag gtcccggtgg
     8881 accggacggg ggcggtgtcc ccgtcggcgt acgcggcggc cctgcgcccc gacacggcgc
     8941 tcgcctgcct ccagtcggcc aaccacgagg tcggcaccgt gcaaccggtc gaggccgtcg
     9001 ccgaggcgtg ccgggcggcc ggggtgccgc tgctggtgga cgccgcgcag tcgctggggt
     9061 ggggtccggt ggacggggcg tggtcgctgc tgaccgcgag cgcgcacaaa tggggcgggc
     9121 ccgccggggt ggggctgctc gccgtacgca agggcgtgcg gttcgctccc caaggcccgg
     9181 tggacgagcg ggagtcgggg cgcgtacccg gtttcgggaa tctgccggcg atcgtcgccg
     9241 ccgccgcgtc actgcgggcg gtgcggtcgg aggcggagcg ggaggcggcc cggctgcggg
     9301 tgctggtgga ccggatccgg gcgcgggtgc ccgagtcggt gcccgatgtc gaggtggtgg
     9361 gcgatccggt gcacagactc ccgcatctcg tcaccttctc ctgtctctat gtcgacgggg
     9421 agactctgct gcacgaactg gaccgggcgg agttttccgt gtcgtcgggt tcgtcctgca
     9481 cgagcagcac actgaccccc agccatgtgc tgcgggcgat gggggtgctc tcggagggca
     9541 atgtcaggat ctcgctgccc tccggtacgg ccgaggcgga ggtggagcgg ttccttgagg
     9601 tgctgccggg ggtggtcgcg ggcgtacggg agcggctggg cgttccggcg acggcgcggg
     9661 agggcggcgg cgaaacggcg ccggacgcgg cgtcggtggt cgtggacgcg ctcggcaggc
     9721 tgtgcccgat cccggtgatc gagctggcca aggtgatcgg ggacgtaccg gtgggcggca
     9781 cggtgaccgt cctgtccgac gacgaggccg cccgcctgga catcccggcc tggtgcgaga
     9841 tgcgcggaca cgagtacggc ggccggagcg gcaccgcgtt cctggtgcgc cgcctcgtct
     9901 gaaccgccgg ccgtacgggt actccctctc ctcccgctcc tcgctcatcc gttcccgtca
     9961 tgtccggcgt attgtctccg tgcgcccgcg cgcgtacgac tcaggtcttc cggtaggcga
    10021 cgcgcagggc catggcgccg agttcgtcgc gccagacctg gtccatgggc gcggcgtcga
    10081 gcgccgcgcg gccacgttgg acgagttcgt cgatgtgctt ctccacgtcg tccgggacgc
    10141 ccgtcgcgac gagcaggtcg cgcagttcgt ccgcgtcgtg tccgggggtg gtgaccaggt
    10201 cgcggacccg ctcgtcacgc tgcatggccc agccgagcag cagcgtcatc ttgtgctggg
    10261 agaagtcgag tccggcgggc ttgcccgtct cggtggggtc cccgaacgcg cccagcaggt
    10321 cgtcgcggag ctggaacgcc tcgccgaccg cgcctccgta ctcctcgaag gccgcggcga
    10381 gtccggtggc cccggcgagg gtggcgccga cgacgagggg ccggtgaatg gtgtagcggc
    10441 cggacttggc gagcgcgatc cagcgggaga gttccgggtc gacggagaat tcggccgccg
    10501 acgcgacgtc catgtactga ccgatgatca gctccgcgcg cagttcgctc cagacgggga
    10561 cgagcgcggg aggcgcctcg gccatcagcc ggtcggagta gatgagcgcc aggtcaccgg
    10621 cgaggatcgc cacgctctcg ccgaatcggc gggcctcgcc ctgccagccg cgctccctgt
    10681 gctcggccga gtgcttcata tggacggtgg gcgcgccgcg acgctgtccg gccgcgtcca
    10741 tgacgtcgtc gtggatgagg gcgcaggcgt gcagcatctc cagcgcggcg gcggccggta
    10801 cgactccggg cgcgtccggg gcgccgcccg ccgcgaggta tcccatgacg cagaaggcgg
    10861 ggcgcagccg cttgccgccg gagtcgatca ggtcggccac cgccccgacg gggaccgggg
    10921 cgcgcttgtc gacggccgtc cagatctcgt tctcggccgt gaggaagtcg cgcaggcggt
    10981 gttccacccg ctccagcagg tggcgcgtgg tgcggcgcgc ggagtccgcc gtcagcacgc
    11041 cgttgtcgga ccgggcggtc acttcggtgg tcacacgtgt ctcctggggc tctatcggaa
    11101 ttactaaaat cttccttgag ggaaacttga attacggtcc agtaatccag cacctcaaga
    11161 tggacgtacc gccacacaca ttcaccaaca ggtcacaact ccctcgggag acaaagtcgt
    11221 tgacaagccc aagcactcat gggaggatcg tggccctatt gtcccgagtt cgttatcggg
    11281 tcaacgcgga accggggggt ccgcatggaa acaaagcctg cccaaatatc tggggcagca
    11341 tccaagacat ccagaacaat cgtcctccgc ggattacttc gcctttcgaa gatccgcgtt
    11401 ttccagcact acttcggtct cgctctcgca tggctgctgc tcagcccgga agcgctgcaa
    11461 cgaccgggtg ccacgaccgc gatgctcctc ttcctactgg gctcggtcgc cattgtcgcg
    11521 tgtgcgtgcg ccagcgacga catagcagga ttcagaaatg gcagcgacct gatgaactac
    11581 cagtcggacg agcagctgcg cgacattcac gcgaagccgc tgctgaccgg cgccgtcacc
    11641 gagagacagg ctctcacctt cgccgtcgga tcaggcttcc tggccgtacc ggccggggcg
    11701 gcggcattct gggcgctcga ctgggacgct cccttcagcg cctatgccct ctatcttctg
    11761 ggattcgcct tcagcgtcca gtactcggtg ggcctgaggg tgagctaccg gcgcggcggc
    11821 ggcgagacgc tgctctgctt ctccaccgcc gcggggctgc tcgcgccctt cctcgcggtg
    11881 aaccgcgact ggacctggcc ggccgtcgcc caggccctcc tgctcggcct ctggctggtc
    11941 atggtcagca gctactccaa cgtcaacgac gtggcgggcg accggatggc gggccggcgc
    12001 accttggccg tgaccacggg cagaaccgtc cagaacgcgg ccatggcctc gttcttcctg
    12061 ctctcggccg gtctgctcac cgcgctcgcg atgaccggcg gatggccggg gtggctgctc
    12121 ctcaccgcgc ttcccgccac cgtcctgcac gcggcgcagc tctatcacgg gccggtcaga
    12181 ggccagtggc tccgggccag gaagctcgga ctcatcgcgt acaacctcgg gttcgccggc
    12241 atcgccgtac cgacgttctt cgcccttcac cggtagccgc ggcggccggg aatccagaac
    12301 accacggcga attcggttca ttcacttggg ggaaagacaa tgaccggacc actgtgcgag
    12361 cgagaccata tggtggagac ggagtcgatg gcagggctcc ggctgtgcgc accctgtcta
    12421 cgacagacgg aaagaaatct caccagcctt cccgctctgc acgaggagtg cgtcgaccat
    12481 gttttcgggg gtccccggaa cccggctcgg caacgagtgg cgggaagccg agacgtgtcc
    12541 cctctcaatg attcggccat cgagacacgc agcaacatat ccggtgtgct catcgcatgg
    12601 tcgagcagtg tcgccgaaga gaaaggcaca cccgcacccg gctcctccgt gcggcgcctg
    12661 acgcactttc tcctcaccca tctgcactgg ctcgccacgt ccaccgaggc cgtggtcttc
    12721 gcggacgaga tcgagaatct gacgacggag gcgcgccgga cgatcgatcc ggcaccggag
    12781 gcccggctca tcacgctggg ccggtgcgtc gaacccgact gcgcggaaat catcaccgcc
    12841 gcggcaccgg gccggcgaat cttgaattcc cgcagtatca gctgcgccgc cgggcattcc
    12901 tgggaggttc acgaatggtt ccttctccag agccgtatcg agcagaagaa gggggtcagc
    12961 gcgtgaccag gccgccacgc caccggcgcg ttccgacgaa agcggccgcg ctcgccgtgg
    13021 gtgttccgga agcgacgatc cgacagtggg tacgcagggg gaagctcacc cgctacggca
    13081 ctcccggccg ggccgagttc gacatcgcgg aactgaccgt gatcgcgaag gggccggacc
    13141 gctgagcacc gcggggccgg accacccctc ctggagcggg tggcccggcc ctgcgacggg
    13201 ccgggctcca cggtcctccg ggtgccgggg gtccgtcaga actcgctgat ccgctcggcc
    13261 accttgatcc cgacgtgccg tccgggctcg gtgacgtggc cgaggagctc ggtgcccggc
    13321 actacgtcgg tgaggttgag cggtttgccc tcggcgctca tcacccgcac gtgccagtcg
    13381 tcctggagga agacgttgac cttgacgtcc ccgtacgtgg cctcgatgag ccgcagcgga
    13441 cggagttcga ccttcacccg gccgaccacg acctcgcgga acgtgccgtc cgccgagacg
    13501 gcgtgcgaac gctccccggc ggcgaggtcg gtgatgtacg cggtggtgtc cgccccgaag
    13561 acgtagctgt gcacggcacc ggcgttcacc cggaacgggc ggaggttcat gtacggcagg
    13621 tagtgcacct ccgcgcagac caggatgccg ccggaggacg tcgagccgac gatcatgccc
    13681 tcgtcctcgc cgaacagcgt ggccgtgtcg acacagcccc ggtagcccat gccgatcggt
    13741 tccgcgcgta cgacctccag cggcacgagg tccttgcgga cctgccggcg cagccgcagc
    13801 gcctcgccca cccggtcgat gtcggcgagt tggtcaccgc ggacgaccag gccggcgggc
    13861 ccgctctcca gcacaccggc gacgctggcc gtctcggccg agctgagcag ttccttcagc
    13921 acccgcgtcg tgccgtcctg ggcgcgggcc agcagcagct ccagcgggat gttggtctcg
    13981 tcgatgaagg ccgccaccag cacatcggcc ctgccgcaga ggtcggccgc cacgttcatg
    14041 gtgtcgccgt cgacgatctc gcagcgcacg ccgaccggcc ggccaccggc gagggcccgg
    14101 acggtgtcga gctgcgccgg tgcctccacc agcaaaatgc ccacccgctg gtcgtccagt
    14161 gcggcggggg cgttgtccgc gtccaccagg gcggccaggg tgatccgctc aagcggttcc
    14221 cagccgtcga gctggtcggg gcgcagcagg accgtcgtcg cggcggagga ccgcgcgtgt
    14281 gcgagggccg ccgccgtgtc gtcggggccg agtcccgtga cgtccgccca gagttcctgt
    14341 tccgtgtcca cgtgccatcc gttctgagag gttccgaggg ttgcgagagc gctgacggct
    14401 caggggtgcg ggagggtgac gcgtgccctg gctcagccgg agccgtgcac gacaccgcgg
    14461 agttcggccg tggcccgcgc ggggtcgacg ctgccgaaca cccggcggcc gacgcagaga
    14521 ccggcgatgc ccgcgccgat cgcgttcttg gcggagttga ggaaggcgtc ccaggagccg
    14581 tccgggccgc cgccggcgat caccacgggc accggcacct gggcggccag atcggtgagg
    14641 tactgctcgc cggggtgggc cgccttgacg atgtccgcgc ccagctcggc cgcgatccgc
    14701 gaggcgtgca gcacatcggg gccgatgtcc gtcgcctcgg tcctgatgta cgtcatcacc
    14761 agcagcggca tgccgagccg gtcgcaggag cgggcgacgg cgccgagccc cacgagcgcg
    14821 tcgcggtcct cccggtggcc gcagccgagg gtgatgtgcg ccgacacggc gtccgcgccc
    14881 atcgcggcgg cggtctccgg ttcgcagacc gtggccttga gttcggactg cgggctgagc
    14941 gcggtgttgc ccgacaggtg cacgatcatc gccgtgtccc gctgcacggg catctcccgg
    15001 gcggccgatc cccggtgcgc gacgatgccg tccgcgccac cactgaccac ggagcgcatg
    15061 acggagccca tgttggtcag tccgccgacg acacccgtgg tcaccgagtg gtcgagcgcc
    15121 acgagcagcg ttctgccgtc ctccgcgatc agccgacgca gccgtcgttc ttttccgttc
    15181 accgctgtca ctgccctacc tctccctcgc tggtctccgg cacgacgcag gggccggctc
    15241 gggcgcggac ggcgccggag ccggcccctg cgggcggccg gtcggttcgg ttgctacgga
    15301 caactcacat acggtcgggt gcggacacgc cctcgcgtgc cgcggtcacc ggcacaaggt
    15361 gttcggcgtc cggcgcgccg tcgtactcct tcaggccgaa cctggcgtgc acgcgccgca
    15421 acggggcggg tgcacgccag gtggcgcgcc cgccgagccg catcagcgcg ggcagcagca
    15481 gtccgcggat cagggtcgcg tccatcagga cggccagcgg caggccgatg ccgtacgcct
    15541 tggacagcgt gatgtccgag acggcgaagg cgaggaacac cacggagatc agcaccgccg
    15601 cggcggtgac gatccgtccg atgcgctcca ggccgcgggc gaccgccgcg ctcccgtccc
    15661 cggtgatctc gtactcctcc ctgatcctgg ccagcaggaa gatctggtag tccatggcca
    15721 ggccgaagga cagcgcgaag agcatcacgg gcaccgtggc cgcgatgtcc cccgtgacgg
    15781 tgaatccgcc gagcagaccc gcgagatgac cgtcctggaa gatccacacc agcgccccga
    15841 aggtcgccac cgggtgtgac gtgagtcact cggtgagccg gggtgtgtac gggcggaaga
    15901 accgcgccgc ccaccggggt ccggttggcg gcgcgtcggg gcggcggccc ctacctcagg
    15961 tgcgcgcgga cctcggtggc cgcttcgtcg ccgtacgcct tggtgaagcg gtccatgaag
    16021 ttgttccggc gcagcgtgta ctcctgggtg ccgagtgtct cgatgaccag ggtcgcgacc
    16081 atgcagccga cctgcgcggc ccgctccagg ccgactcccc acgacagccc ggacaggaag
    16141 ccggcgcgga aggcgtcacc gacaccggtc gggtcgacct tggccgtctc ctccgcacag
    16201 ccgacctcga tcgggtcgtc gccgacccgc tcgatccgga caccgcggga gccgagcgtg
    16261 gtgacccggt ggccgacccg ggagaggatc tcggcgtcgg tccagccggt cttggactcg
    16321 atgagcccct tctcgtactc gttggagaac aggtacgtgg cgccgtcgag cagcagcctg
    16381 atctcatcgc cctccatccg cgcgatctgc tgcgagaagt ccgcggcgaa cgggatggac
    16441 ctggtgcggc actcctcggt gtgacggagc atcgcctcgg ggtcgtcggc gccgatgagc
    16501 accaggtcga ggccgccgac ccggtcggcc accgacttca gctcgatctg ccgggcctcg
    16561 ctcatggcgc cggtgtagaa ggagccgatc tggttgtggt cggcgtcggt cgtacacacg
    16621 aagcgcgcgg tgtgcagcac ttcggagacc cggacggacg cggtgtcgac accgtgtcgg
    16681 tcgagccagg cgcggtactc gtcgaagtcg gggccgacgg cgccgaccag gatcggcgcg
    16741 gtgccgagct ggcccatgcc gaagcagatg ttggcgccga caccgcctct gcgtacgtcg
    16801 aggttgtcta cgaggaagga aagcgagacc gtgtgcagct ggtccccgac caactggtcg
    16861 gcgaagcgac cggggaaggt catgaggtgg tcagtggcga tggagccggt gactgcgatt
    16921 ctcacggcgt gactgctcct gtggaggaga acaatggaca gctcacgcta tctggtcggc
    16981 actcgcgcca cgacggagca gaactacccg atagtagggc ttttctctca accggtccgt
    17041 gcttacggtg cgtacatgag gaaccacacc gtcccccgcg agcgctccgt acgtgagtcc
    17101 gacaccagcc tggccgagct gcgcggcgac tgcgcccgga tggcgccgca ctgggtgagg
    17161 ccggccaccg ccgctccggt ccccgtcccc ccgtcgctca tccatggcgt cacggtcccg
    17221 tcggcctcgg cccggctgat cgacggcatg tcggagtacg gggactagtc cccccggggg
    17281 aaccgcgcgc tcgcgccgac cgtcccaccg ctgtcccggc ccggcagggt gatccggtcg
    17341 aaggagcaga cgatgacgag tacggaacga cctcaggacg gcgacggcga acgtaacggg
    17401 tggcggcgct cccccttcgc cgtcgtgtcg gtggtggcgg cagtcctgct cgccggcggt
    17461 ggcggcgcct acttcgccac cacctcgtcg gagggcggcg gtgacggcaa gtccgccgcg
    17521 cgcggcgcgg gggacctcga tccgccgccg ctggcgctcg gcgcggacgc gggcggtggg
    17581 gcgggaagga atcccggcct cgggatcgcg cccggtgagc cgagtccgta cggagtcgag
    17641 taccgcgcct cgggcacgct gcccgagggg cccgattcgg ccgccgtgca ccgtcccgaa
    17701 ggatccgtcg ccgcggccga cgtggcgcgt ctcgccaagg ccctgggggt gtccggcaca
    17761 ccggaacgct ccggtacggc ctggaaggtc ggcggccaca aggacggttc ggggccgctg
    17821 ctcactgtcg accaacaggc gcccggcgac tggacgttcg gccgcttcgg gcccgcgccc
    17881 ggcggtgacg actgcctcaa gggcaaggag tgcccgagcg gcgacggagg cgggagcaac
    17941 cccgtcgtgc ccggcgacgg ggcgggcccg gtgagcgagc gggccgcgaa gaaggccgcg
    18001 gcgcccgtgc tgaaggcgct gggccaggag gacgccgcgc tcgacgcggg ccagctgatg
    18061 ggcgccgtac gggtggtgaa cgccgctccc gtggtcgcgg ggctgccgac gtacggctgg
    18121 tcgaccggta tccagatcgg tgcggacggc caagtggtcg ccggcagcgg gaagttgaag
    18181 gagccggcaa agggcgccga gtatccggtg gtgagcgccg tcgaggcgct gaagctgctg
    18241 aacggggcgg cgggcgaccg gggcacgagc gggatcggcg gctgcgcgtc cgcggtgccc
    18301 cagaaggacg gccgcgagcc ggcggcgccg tgcgagccgg gaggcacggg cgtgaagccc
    18361 acgcaggtac ccgtgggcaa ggcggttttc ggactggcgt cgcgtcaggt ggagggacgg
    18421 gccgcgctcg taccgtcgtg gtggttcgag gtggcgggcg ccggggacgg tccggcgtcg
    18481 ttcgtcaccc ggacggcggt gcttcccgag tatctgacgc ggggcggcgg gagcggtgac
    18541 ggcacggacg cgggcccggg caacgacgac ggcgcggtcc gccaggacag cgacgaaccg
    18601 ggattcccgg tcgagacgta cagcgccgac gggagcacgc tgagcgtgcg cttcaggggc
    18661 gccccgtgtg gcgagtactc ggtgcgggcg gaagagagcg ggtcggtggt gaaggtggag
    18721 gtggtcgact ccgcgccgcg ccgtgtgtgc atcgcgatct ccaaggcgct caccgagaag
    18781 gtgacgctgg acaagcagct cggcgaccgg aaggtcgtgg acgcggtcac cggggacgcc
    18841 gtcccactga ggaagtaggc cacgcacgcg aaaaggcggc ggcccctgat gaggggccgc
    18901 cgccttttcg ctgtcccgtt acggggcgga cgactcgggt cgccgggcgg cgatcagttg
    18961 aaggagtcgc cgcaggcgca ggaaccggag gcgttggggt tgtcgatcgt gaagccctgc
    19021 ttctcgatcg tgtccacgaa gtcgatcgag gcgccgccca gatacggggc gctcatccgg
    19081 tcggtgacga ccttgacgcc gtcgaagtcc ttcacgacgt cgccgtccag cgaacgctcg
    19141 tcgaagaaca gttggtaacg gagaccggaa cagccgccgg gctggaccgc gacgcgcagc
    19201 gcgaggtcgt ccctgccttc ctggtcgagc agggccttga ccttgcccgc ggcggcgtcg
    19261 gacaggagga tgccgtcgct cacggtggtg gtctcgtccg atacggacat ctgcttctct
    19321 cccggggtgg ggcctccccg ccgaggcagg ggaagaacgg actcattgcc gacagctaca
    19381 accgtcaagg ccgcggaatc attccgggct cgccgctcgc ctcgtctgtc gctcttctcc
    19441 tcatgctcgc acacccggct ccggagcggc accgaccgcc gttcccggga atgcgtcaca
    19501 tcgacgctat cgacatcgtc aaagtgacgt gaagcggtta tgatagataa cgtcaattag
    19561 acgaaaaggc tcctccgcag agaagaaagg gtgcgtgacg tgaccacggc ccaagcccgt
    19621 caggatctcg ctgtacagcc gacgcccctc gcgctgctcc tgctcggccg cgaggccgac
    19681 acccggagcg agcgcggcgt ggactgcccc ggtgacctgc cgtcgccgtc cgacccggat
    19741 ctggtcgaac gcgcccgcgc ggcgaaggag aagctcgggg agaaggtctt catcctcggc
    19801 caccactacc agcgcgacga ggtcatccag ttcgccgatg tgaccggtga ctcgttcaag
    19861 ctcgccaagg acgccgccgc gcgccccgag gccgagtaca tcgtcttctg cggtgtgcac
    19921 ttcatggccg agtcggcgga catcctgacg gccgacgacc agaaggtcgt cctgcccgac
    19981 ctggccgcgg gctgttcgat ggcggacatg gcgacggccg agcaggtcgc cgagtgctgg
    20041 gacgtgctga ccgaggccgg catagccgag cgggtcgtcc ccgtctcgta catgaactcc
    20101 tccgccgaca tcaaggcgtt caccggcaag cacggcggca ccatctgcac ctcgtcaaac
    20161 gccgagcgcg ccctcgactg ggccttcgag cagggcgaca aggtcctctt cctccccgac
    20221 cagcatctgg ggcgcaacac ggccgtacgg gacctggggc tgtcgctgga ggactgcgtc
    20281 ctctacaacc cccacaagcc gaacggcggc ctgacggccg aggagctgcg gaacgcgaag
    20341 atgatcctgt ggcgcgggca ctgctccgtg cacggccgtt tctcgctgga ctcggtcaac
    20401 gaggtccgcg agcggattcc cggggtgaat gtgctggtgc acccggagtg caagcacgag
    20461 gtcgtctccg ccgccgacta cgtgggctcg acggagtaca tcatcaagat gcttcagcag
    20521 gcgccggccg gctcgaagtg ggcgatcggc accgagctga atctggtgca gcggctggcg
    20581 aaccgtttcg ccgccgacga caaggagatc gtcttcctcg acaggacggt ctgcttctgc
    20641 tcgacgatga accgcatcga cctgccgcac ctggtgtgga cgctcgaatc gctcgccgag
    20701 ggcaaggaca tcaaccggat ccaggtcgag aaggagacgg cggacttcgc ccagctcgcg
    20761 ctggagcgga tgctggcgct gccgtagccg acaggccgta cgggcgccgc gaaggccgta
    20821 cgggaaacag cggagagggg cgcccgccaa tggcgggcgc ccctcactcg ttcaccggtc
    20881 cggacctccc ggccggacgc cgggcgtcag gcgttgaccg gctccggtga cggcgcgtcg
    20941 gagcgcggcg taccgccgcc accgctcccg ccgtctccgc cgtccccgcc gccggacttc
    21001 gccgcccgct tcgccgcctt cttcttggcg cgccgctcct tgcggagctc gaccatcgag
    21061 tacagcgtcg gcac
//
