LOCUS       NZ_CP048397            10399 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. S4.7 chromosome, complete genome.
ACCESSION   NZ_CP048397
VERSION     NZ_CP048397.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S4.7
  ORGANISM  Streptomyces sp. S4.7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.
  TITLE     Viennamycins: new lipopeptides produced by Streptomyces sp. S4.7
            isolated from the rhizosphere of Edelweiss (Leontopodium nivale
            subsp. alpinum)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7920066)
  AUTHORS   Bekiesch,P., Zehl,M., Domingo-Contreras,E., Martin,J.,
            Perez-Victoria,I., Reyes,F., Kaplan,A., Ruckert,C., Busche,T.,
            Kalinowski,J. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2020) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.8x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010384365.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 10:27:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,027
            CDSs (total)                      :: 6,939
            Genes (coding)                    :: 6,650
            CDSs (with protein)               :: 6,650
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 289
            CDSs (without protein)            :: 289
            Pseudo Genes (ambiguous residues) :: 0 of 289
            Pseudo Genes (frameshifted)       :: 103 of 289
            Pseudo Genes (incomplete)         :: 223 of 289
            Pseudo Genes (internal stop)      :: 23 of 289
            Pseudo Genes (multiple problems)  :: 52 of 289
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:05:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1508065
            Orig. end                         :: 1518464
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048397.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zotchev Lab, University of
            Vienna, Austria.
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="5"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(260..1351)
                     /locus_tag="SSPS47_RS06675"
                     /old_locus_tag="SSPS47_06795"
     CDS             complement(260..1351)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989359.1"
                     /locus_tag="SSPS47_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_06795"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_164249486.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 4.2e-16, bitscore:
                     57.7, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDRAVLHVKGRVLVGPDDVRDELWVVDGRTSYERPSGARDVRTV
                     RGWAVPGLVDAHCHVGLDTHGPVDEATSEKQALTDRDAGTLLLRDAGSPSDTRWIDDRE
                     DLPKIIRAGRHIARTRRYIRNFAHEIEPGDLVAFVAREAVRGDGWVKLVGDWIDREAGD
                     LTACWPRAEVGAAIAEAHRLGARVTAHCFADVALRDLVEAGIDCVEHATGLTDELIPLF
                     AERGVAIVPTLVNIATFPDLAAGGEGKYPRWSAHMRRLHARRYDTVRDAYDAGIPVFVG
                     TDAGGSLAHGLVADEVAELVKAGIPPLEALSATAWNARAWLGRPGLEEGAPADLVVFDE
                     DPRVDVRVLAEPRRIVLNGRVVG"
     gene            1498..2610
                     /locus_tag="SSPS47_RS06680"
                     /old_locus_tag="SSPS47_06800"
     CDS             1498..2610
                     /NRPS_PKS="Domain: Aminotran_5 (17-339). E-value: 4.2e-27.
                     Score: 86.9. Matches aSDomain:
                     nrpspksdomains_SSPS47_RS06680_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018518886.1"
                     /locus_tag="SSPS47_RS06680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_06800"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_164249488.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.3e-21, bitscore:
                     75.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPLLDLAPLTPARFAAVERRVAALLDTEQDVVITQGEALLPLE
                     GCVRGGARAGSTALNVVTGPYGQTFGDWLRDCGATVVDLEVPFHAAAGAEQVERALAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEAVRAHGALFMLDAVASVAAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSARAWERLAANPGAPRRSYLSLLDWKERWIDTGRKALPHAP
                     AQLEMLALDACLERIESEGLVTRMAAHASAAAATRAGALALGGGLEPFVYSVRDAAPVA
                     TTLRTPAGVDAAALVTEALAADSSLPLIAGGGALSKEMIRVNHYGSDATRGAVRASLGA
                     LGAALAGAGVPVDLAAAEKAVSDSWPADAS"
     aSDomain        1549..2514
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SSPS47_RS06680_Aminotran_5.1"
                     /evalue="4.20E-27"
                     /label="SSPS47_RS06680_Aminotran_5.1"
                     /locus_tag="SSPS47_RS06680"
                     /protein_end="339"
                     /protein_start="17"
                     /score="86.9"
                     /tool="antismash"
                     /translation="AVERRVAALLDTEQDVVITQGEALLPLEGCVRGGARAGSTALNVV
                     TGPYGQTFGDWLRDCGATVVDLEVPFHAAAGAEQVERALAEHPEIDFVSLVHAEAATGN
                     TNPVAEIGEAVRAHGALFMLDAVASVAAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAVS
                     VSARAWERLAANPGAPRRSYLSLLDWKERWIDTGRKALPHAPAQLEMLALDACLERIES
                     EGLVTRMAAHASAAAATRAGALALGGGLEPFVYSVRDAAPVATTLRTPAGVDAAALVTE
                     ALAADSSLPLIAGGGALSKEMIRVNHYGSDATRGAVRASLG"
     misc_feature    2684..2693
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.42"
                     /tool="antismash"
     misc_feature    complement(2697..2714)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.86"
                     /tool="antismash"
     misc_feature    complement(2752..2767)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(2762..2777)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     gene            2934..3527
                     /gene="ectA"
                     /locus_tag="SSPS47_RS06685"
                     /old_locus_tag="SSPS47_06805"
     CDS             2934..3527
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123622.1"
                     /locus_tag="SSPS47_RS06685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_06805"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_164249490.1"
                     /transl_table=11
                     /translation="MTAAQADLAGVRSEFTRSFRIDAPRVEDGAAIWRIARDSEVLDLN
                     SSYSYLLWCRDFAATSVVARDTRSVASCDTDTGSGPGVGSDGAPIAFVTGYIRPERPEA
                     LVVWQVAVDRAHRGKGLAGTLLDALTRRVTEEQGITSVETTVTPDNIASDRMFHAYCER
                     HGATLEREVLFDGGLFPDEGHQPEVLYRIGPLTT"
     gene            3586..4854
                     /gene="ectB"
                     /locus_tag="SSPS47_RS06690"
                     /old_locus_tag="SSPS47_06810"
     CDS             3586..4854
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-365). E-value: 2.1e-71.
                     Score: 232.6. Matches aSDomain:
                     nrpspksdomains_SSPS47_RS06690_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156968.1"
                     /locus_tag="SSPS47_RS06690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_06810"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_147872109.1"
                     /sec_met_domain="Aminotran_3 (E-value: 5.4e-75, bitscore:
                     251.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITPPVLSVFETLESEVRSYCRGWPAVFDRAQGSRLTDEDGHSY
                     LDFFAGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMATTAKRAFLESFQDVVLRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKNRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGQVPDFLWFERLLGDQGSGLNKPAAVIVETVQGEGGINVARP
                     EWLRALSELCERQDMLLIVDDIQMGCGRTGGFFSFEEAGITPDIVTLSKSISGYGLPMA
                     LTLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALNTYWADGQMEKQTLARGEQVERALL
                     AIVDECEPDSVSFRGRGLVWGMEFQDKPRAGAICRRAFELGLLLETSGPESEVVKLLPA
                     LTVTPEELDEGLRTLARAVRETA"
     aSDomain        3670..4680
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SSPS47_RS06690_Aminotran_3.1"
                     /evalue="2.10E-71"
                     /label="SSPS47_RS06690_Aminotran_3.1"
                     /locus_tag="SSPS47_RS06690"
                     /protein_end="365"
                     /protein_start="28"
                     /score="232.6"
                     /tool="antismash"
                     /translation="FDRAQGSRLTDEDGHSYLDFFAGAGSLNYGHNNPVLKRALIDYIE
                     RDGITHGLDMATTAKRAFLESFQDVVLRPRDLPYKVMFPGPTGTNAVESALKLARKVKN
                     RESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGQVPDFLWFER
                     LLGDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALSELCERQDMLLIVDDIQMGCGR
                     TGGFFSFEEAGITPDIVTLSKSISGYGLPMALTLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALNTYWADGQMEKQTLARGEQVERALLAIVDECEPDSVSFRGRGLVWGMEFQ"
     gene            5001..5399
                     /locus_tag="SSPS47_RS06695"
                     /old_locus_tag="SSPS47_06815"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123624.1"
                     /locus_tag="SSPS47_RS06695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_06815"
                     /product="ectoine synthase"
                     /protein_id="WP_078077956.1"
                     /sec_met_domain="ectoine_synt (E-value: 5.9e-54, bitscore:
                     179.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIENTDRHVKSASGTWESKRIVLAQEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCVEGEAELTNDDTGETHWIAPGTMYLLNGHEKHTLRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEEG"
     gene            5406..6302
                     /gene="thpD"
                     /locus_tag="SSPS47_RS06700"
                     /old_locus_tag="SSPS47_06820"
     CDS             5406..6302
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448161.1"
                     /locus_tag="SSPS47_RS06700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_06820"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_164249492.1"
                     /sec_met_domain="PhyH (E-value: 5e-37, bitscore: 126.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPARTDLYPTRGVGEVTTPRQDPVVWSPPGTPGPVSQADLQG
                     LERDGFLTVDQLINPDEVSLYRAELERLITDPAVRADERSIIEPKSQDVRSVFEIHKIS
                     EVFAGLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPN
                     MRTISVSIALTENYDTNGGLMIMPGSHKTFLGCAGETPKDNYKQSLKMQDAGTPSDEAL
                     TGFAEQHGIKLFTGKAGAATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFAA
                     PSPRPSFIGSRDFTPVR"
     gene            complement(6381..7439)
                     /locus_tag="SSPS47_RS06705"
                     /old_locus_tag="SSPS47_06825"
     CDS             complement(6381..7439)
                     /NRPS_PKS="Domain: Aminotran_5 (14-345). E-value: 2.8e-23.
                     Score: 74.3. Matches aSDomain:
                     nrpspksdomains_SSPS47_RS06705_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948835.1"
                     /locus_tag="SSPS47_RS06705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_06825"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_164249493.1"
                     /sec_met_domain="Aminotran_5 (E-value: 7.4e-18, bitscore:
                     63.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTLGGAEFAPETTYLNTSTCGLLPRRAVEAVRALALSSGTGQPD
                     GAGDFDVVEAARASFARLVRVPADRVAVGTAVAVHVGLIAASLPPGSEVLLPEGEFSSV
                     VTPFTVRGDLKPRYVPLESLAAEVRPETALVAFSAVQSSDGRTADLAGVRAAAAAHGAR
                     TLLDATQAAGWLPIDAGQYDYTVTGGYKFLVSPRGTSFLTVGEEAQETLVPILAGWVAG
                     QDMWASTYGPVGELAVSARRFDQPVPFLAYHGAERSLPLLNDIGVEKIHTHDAALAARF
                     RAGLREIGHEPAGTGHAEGSAIVAVAGLGDRQEALARAGVAVAVRAGNLRAAFHLYNST
                     ADVDRALDVLAG"
     aSDomain        complement(6405..7397)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SSPS47_RS06705_Aminotran_5.1"
                     /evalue="2.80E-23"
                     /label="SSPS47_RS06705_Aminotran_5.1"
                     /locus_tag="SSPS47_RS06705"
                     /protein_end="345"
                     /protein_start="14"
                     /score="74.3"
                     /tool="antismash"
                     /translation="YLNTSTCGLLPRRAVEAVRALALSSGTGQPDGAGDFDVVEAARAS
                     FARLVRVPADRVAVGTAVAVHVGLIAASLPPGSEVLLPEGEFSSVVTPFTVRGDLKPRY
                     VPLESLAAEVRPETALVAFSAVQSSDGRTADLAGVRAAAAAHGARTLLDATQAAGWLPI
                     DAGQYDYTVTGGYKFLVSPRGTSFLTVGEEAQETLVPILAGWVAGQDMWASTYGPVGEL
                     AVSARRFDQPVPFLAYHGAERSLPLLNDIGVEKIHTHDAALAARFRAGLREIGHEPAGT
                     GHAEGSAIVAVAGLGDRQEALARAGVAVAVRAGNLRAAFHLYNSTADVDR"
     gene            complement(7509..8243)
                     /locus_tag="SSPS47_RS06710"
                     /old_locus_tag="SSPS47_06830"
     CDS             complement(7509..8243)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018518879.1"
                     /locus_tag="SSPS47_RS06710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSPS47_06830"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_164249495.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYIGKARFEKGLESFARRADVEVVHRSFELDP
                     GHAKGDVAPVVDMLAAKFGRSRQEALAMEEQVASHARSEGLGYRVGDRDHGSTFDIHRL
                     LHLAKARGRQDELLSLVYRANFAEERSVYDTGTLVDLAVEAGLDEAETRAVLGDADAYA
                     EEVRADEREAAELGATGVPFFVLDRRYGVSGGQPAEVFTQALEQAWQNRAITPLVGVTE
                     DGQGAACDTDGSCEIPQAGARS"
     gene            complement(8378..9564)
                     /locus_tag="SSPS47_RS06715"
                     /pseudo=""
     CDS             complement(8378..9564)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655786.1"
                     /locus_tag="SSPS47_RS06715"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="GTP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTTLNLGILAHVDAGKTSLTERLLHAAGVIDEIGRVDDGNTQTDS
                     LALERQRGITIKSAVVSFAIDDVTVNLIDTPGHPDFIAEVERVLSVLDGAVLVVSAVEG
                     VQAQTRVLMRTLRRLRIPTLVFVNKIDRVGARRPPRGFRQGRPARRAHPARRAGPADQS
                     AAGRDPAGDLRVALRRSAEGGHPGDARRRVRRGRHLPRDHHHLRRTARGHGRRRRGHGQ
                     GAQSVPRDRRTAGRTGPAPATRRARATPTAPSTRACRARAVTSAC"
     misc_feature    10313..10328
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
ORIGIN
        1 gggacacgtg ggcggcgggt gacgaccgag acaccggaat ccttacgcac cgagagtgaa
       61 caggcggaca cctgaggtga gttcactcca aagtgggatt tccgcgtcac cgttcgaatc
      121 ggcgggtacg ggcgttcctc cgggccaccc gcacgggggg tgtggagtcg tgggggagcc
      181 ggttccggca ggcgtacgtg gggcgtacgg cgggcgccgt accgtcaacg cggcaaccgc
      241 ggcaccgcgg ctcccggcct cagcccacga cccgcccgtt cagcacgatc cgccgcggct
      301 ccgccagcac ccgtacatcc accctggggt cctcgtcgaa caccaccaga tcggccggag
      361 cgccctcctc gaggcccgga cggcccagcc aggccctcgc attccacgcc gtcgccgaca
      421 gggcctccag cggcggaata ccggctttca ccaactcggc gacctcgtcg gccaccagac
      481 cgtgcgccag ggagccgccg gcgtcggtgc cgacgaagac cgggatcccc gcgtcgtacg
      541 cgtcgcggac cgtgtcgtaa cgccgcgcgt gcagccgccg catatgggcc gaccagcgcg
      601 ggtacttgcc ctcgccgccg gcggcgaggt ccggaaaggt ggcgatgttg accagcgtcg
      661 ggacgatcgc gacaccgcgc tcggcgaaga gcgggatcaa ctcgtcggtg aggcccgtcg
      721 cgtgctcgac gcagtcgatc ccggcctcga ccagatcgcg cagcgcgacg tcggcgaagc
      781 agtgcgccgt cacccgggcg ccgagccggt gcgcctcggc gatcgccgcc ccgacctcgg
      841 cgcgcggcca gcacgcggtc aggtcgcccg cctcgcggtc tatccagtcg ccgacgagct
      901 tgacccagcc gtcgccgcgc acggcctcgc gggcgacgaa ggcgacgagg tcgcccggct
      961 cgatctcatg ggcgaagtta cggatgtagc ggcgggtgcg cgcgatgtgc ctgccggccc
     1021 tgatgatctt cggcaggtcc tcacggtcgt cgatccagcg ggtgtccgac ggcgagcccg
     1081 cgtccctcag aaggagggtg ccggcatccc ggtccgtgag ggcctgcttc tcgctcgtcg
     1141 cctcgtccac cggtccatgg gtgtccaggc cgacatggca gtgggcgtcg accagaccgg
     1201 gcacggccca gccgcgcacc gtccggacgt cacgcgcgcc ggaggggcgt tcgtagctcg
     1261 tccgcccgtc cacgacccac agctcgtccc tgacgtcgtc agggcccacg agcacacgcc
     1321 ccttcacatg cagcaccgcg cgatcactca tggccgaact gtacgaggcg ctgagtaccc
     1381 tcgacgaggg agtgcccgaa caccgttcga gcggcatgcg gggcgctccc cgttcatcgc
     1441 cgaacacgcc ggctcgccgc cgagcacatc cgtccgatcc gaagagagca cacctccgtg
     1501 acccacccgc tgctggacct cgcccccctc acccccgcac gtttcgcggc cgtcgaacga
     1561 cgggtcgccg cactgctcga caccgaacag gacgtcgtga tcacccaggg cgaggcgctg
     1621 cttcctctgg agggctgcgt ccgtggcggc gcccgcgccg gctcgaccgc gctgaacgtc
     1681 gtcaccggtc cgtacggcca gaccttcggc gactggctcc gcgactgcgg cgccaccgtc
     1741 gtcgacctgg aggtgccctt ccacgccgcg gccggtgccg agcaggtcga gcgggcgctg
     1801 gcggagcatc cggagatcga cttcgtgtcg ctggtccacg cggaggcggc caccggcaac
     1861 accaaccccg tggcggagat cggcgaggcg gtgcgggccc acggggccct gttcatgctg
     1921 gacgccgtcg cgtccgtcgc ggccgagccg ctgctcccgg acgcctgggg cgtcgacctg
     1981 tgcgtgatcg gcgcgcagaa ggccatgggc ggcccggccg gggtctccgc cgtgtcggtg
     2041 agcgcccgcg cgtgggagcg gctggccgcg aacccggggg cgccgcgccg ctcgtacctc
     2101 tcgctcctcg actggaagga gcgctggatc gacaccggcc gcaaggccct gccgcacgcc
     2161 cccgcccagc tggagatgct ggccctggac gcgtgcctgg agcgcatcga gagtgagggg
     2221 ctcgtcaccc ggatggcggc gcacgcgtcg gccgccgcgg ccacccgcgc gggcgctctc
     2281 gcactcggcg gcggccttga gccgttcgtg tactccgtgc gggacgcggc gccggtggcg
     2341 accacgctgc gcaccccggc cggcgtggac gccgcggcgc tggtcaccga ggcccttgcg
     2401 gccgattcct cgctgccgct gatcgccggc ggcggggcgc tgtccaagga gatgatccgg
     2461 gtcaaccact acggctccga cgccacccgt ggcgcggtgc gggcctcgct cggggccctg
     2521 ggggccgcgc tcgccggggc gggggtgccg gtggatctcg cggcggccga gaaggcagtg
     2581 tccgacagtt ggcccgccga cgcatcctga aatcaacgcc ggcattaatt gggaatacgg
     2641 gaatgcattc tgctccacgc agcttcccgt attcgtctgc ccgctttttt tgatcctaaa
     2701 caccaaggtt tcaacaacgg ccacagcgta attccggtgc aggtcgagag cgttacgcat
     2761 atgtgaccga gtacacaagc gcgtccgact tgcccgaaac ctcctggtca aaccagcaca
     2821 gatcacccct ctgccatgtc ggcgcacacg cccgcgtgat aacacagatc aggtcaccgc
     2881 ccaacccctg ctgacgatgc gatttcggaa ttagctcggt aaattaaata gacatgactg
     2941 ccgcccaagc agaccttgca ggtgtccgaa gtgaattcac gcgatccttc cggatcgacg
     3001 ccccacgagt ggaggacggg gccgcgatct ggcgcatcgc ccgcgactcc gaggtactcg
     3061 acctgaactc ctcgtacagc tatctgctgt ggtgtcgtga cttcgccgcg acgtccgtcg
     3121 tggcccgcga cacccgcagc gtcgcctcct gcgacaccga cacgggctcc ggcccgggtg
     3181 tcggctcgga cggggctccc atcgccttcg tcacgggcta catcaggccc gagcgtcccg
     3241 aggccctggt cgtctggcag gtggccgtcg accgtgccca ccgcggcaag ggcctcgccg
     3301 ggaccctgct ggacgcactc acccggcggg tcaccgagga gcaggggatc acctctgtcg
     3361 agacgaccgt cacgcccgac aacatcgcgt cggaccgtat gttccacgcc tactgcgagc
     3421 gtcatggcgc gaccctggag cgcgaagtgc tcttcgacgg gggactcttc cccgacgagg
     3481 ggcaccagcc cgaggtgctg taccggatcg gcccgctcac gacctgagcg accgcccccc
     3541 gccccttcgt ctctctctcc cacacccctt cggcaggaga ccgctgtgac catcaccccg
     3601 cccgtcctga gcgttttcga gacccttgaa tccgaagtgc gcagctactg ccgcggctgg
     3661 cccgccgtgt tcgaccgcgc gcagggcagc cgtctcaccg acgaggacgg ccacagctac
     3721 ctcgacttct tcgccggtgc cggctccctc aactacgggc acaacaaccc cgtactgaaa
     3781 cgcgcactga tcgactacat cgagcgcgac ggcatcaccc acggcctgga catggccacc
     3841 acggccaaac gcgccttcct ggagtccttc caggatgtgg tgctgcgccc ccgtgacctg
     3901 ccctacaagg tgatgttccc cgggcccacg ggcaccaacg ccgtcgagtc ggccctcaag
     3961 ctggcccgca aggtgaagaa ccgcgagtcg atcgtgtcct tcaccaacgc cttccacggc
     4021 atgtcgctgg gctcgctcgc cgtcaccggc aacgcgttca agcgggccgg ggccggcatc
     4081 ccgctggtgc acggcacccc gatgccgttc gacaactact tcgacggcca ggtcccggac
     4141 ttcctctggt tcgagcggct gctcggcgac cagggctcgg ggctcaacaa gcccgccgcg
     4201 gtgatcgtcg agacggtgca gggcgagggc ggcatcaacg tcgcccgccc cgagtggctg
     4261 cgcgcgctgt ccgaactgtg cgagcgccag gacatgctgc tgatcgtcga cgacatccag
     4321 atgggctgcg ggcgcaccgg cggtttcttc tcgttcgagg aggccggcat cacccccgac
     4381 atcgtcacgc tgtcgaagtc catcagcggc tacggcctgc cgatggcgct gacgctcttc
     4441 aagccggagc tggacatatg ggagcccggc gagcacaacg gcacgttccg cggcaacaac
     4501 ccggccttcg tgacggccgc cgccgcgctg aacacgtact gggccgacgg ccagatggag
     4561 aagcagaccc tggcgcgcgg cgagcaggtc gagcgcgcgc tgctggccat cgtcgacgag
     4621 tgcgagcccg acagtgtgag tttccgtggc cgcggtctgg tctggggtat ggagttccag
     4681 gacaagccgc gcgccggcgc gatctgccgc cgcgcgttcg aactgggtct cctgctggag
     4741 acctcaggcc cagagagcga ggtcgtgaag ctgctgcccg cgctgaccgt cacgcccgag
     4801 gagctggacg agggcctgcg caccctggcc cgcgccgtac gcgagacggc ctgaccgccc
     4861 caccgcgtga accgccccac cgcgtgaacc gcccgaccga ccgaccgtct gatccgaagg
     4921 tgaccccagg ggcccggtct gagccgggcc cctgggggaa cccgtagaag acaccgcacc
     4981 acagaagggt cctattcacc gtgatcgtcc gatcgttcaa ggacatcgag aacaccgacc
     5041 gccatgtgaa atccgcgtcg ggcacctggg agagcaagcg catcgtgctc gcccaggaga
     5101 aggtcgggtt ctccctgcac gagaccgtgc tctacgcggg caccgagacg tcgatgtggt
     5161 acgcgaacca catcgaggcc gtgctgtgcg tggagggcga ggccgaactc accaacgacg
     5221 acaccggcga gacccactgg atcgcgcccg gcacgatgta tctgctcaac ggccacgaga
     5281 agcacactct caggcccaag accgacttcc gttgcgtatg cgtcttcaac ccgcctgtga
     5341 ccgggcggga ggaccatgac gagaacggcg tctacccgct gctgaccgag gagggctgaa
     5401 ccacgatgac caccgcccct gcacgcaccg acctgtaccc gactcgtggc gtgggtgagg
     5461 tgaccacccc gcgtcaggac cccgtcgtct ggtcaccgcc cggcaccccg ggcccggtct
     5521 cccaggccga tctccagggc ctggagcggg acgggttcct caccgtcgac cagctgatca
     5581 accccgacga ggtgtcgctc taccgcgccg aactcgagcg gctgatcacc gacccggcgg
     5641 tacgggccga cgagcgctcg atcatcgagc ccaagtccca ggacgtacgc tcggtattcg
     5701 agatccacaa gatcagcgag gtcttcgccg gtctggtgcg cgacgagcgt gtggtggggc
     5761 gggcccggca gatcctcggc tcggacgtgt acgtccacca gtcccgtatc aacgtgaagc
     5821 cgggcttcgg tgcctcgggc ttctactggc actcggactt cgagacctgg cacgccgagg
     5881 acggactgcc gaacatgcgg acgatctccg tgtcgatcgc gctgaccgag aactacgaca
     5941 ccaacggcgg cctgatgatc atgcccgggt cgcacaagac cttcctgggc tgcgcgggcg
     6001 agacgccgaa ggacaactac aagcagtcgc tgaagatgca ggacgcgggg actccctcgg
     6061 acgaggcgct caccggcttc gccgagcagc acggcatcaa gctcttcacg ggcaaggccg
     6121 gagcggcgac ctggttcgac tgcaactgca tgcacggctc gggtgacaac atcaccccgt
     6181 tcccgcgcag caacgtcttc atcgtgttca acagcgtgga gaacacggcg gtcgagccct
     6241 tcgcggcgcc ctccccgcgg ccctcgttca tcggctccag ggacttcacc ccggtccgct
     6301 gaggacgcgc acgtgagagg ggcggggccg gtcgtcggga ccggccccgc ccggcgtgcc
     6361 ccgcccgcgt gcgccgggtg tcagcccgcg aggacgtcca gcgcgcggtc cacgtccgcc
     6421 gtggagttgt acaggtggaa ggcggcgcgc agattgcccg cgcggaccgc cacggccacc
     6481 cccgcccgcg ccagcgcctc ctgccggtcg ccgagccccg cgacggcgac gatcgccgac
     6541 ccctccgcgt gcccggtgcc ggccggctcg tgaccgatct cgcgcagacc cgcccggaag
     6601 cgcgcggcga gcgcggcgtc gtgggtgtgg atcttctcga cgccgatgtc gttgaggagc
     6661 gggagggacc gctcggcgcc gtggtaggcg aggaagggca ccggctggtc gaaccgccgg
     6721 gcggagacgg ccagttcccc gacggggccg tacgtactgg cccacatgtc ctggcccgcg
     6781 acccagcccg cgaggatcgg caccagagtc tcctgcgcct cctcgccgac ggtgaggaac
     6841 gaggtcccgc gcggggagac gaggaacttg tagccgccgg tgacggtgta gtcgtactgc
     6901 cccgcgtcga tcggcagcca gcccgcggcc tgcgtggcgt ccagcagcgt acgggcgccg
     6961 tgcgccgccg cggcggcccg cacccccgcg agatcggccg ttcgtccgtc gctcgactgc
     7021 accgcggaga acgcgaccag cgcggtctcg ggccgcacct cggcggccag cgactccagc
     7081 ggcacgtacc gcggcttgag atcgccgcgc acggtgaagg gggtgacgac ggagctgaac
     7141 tcgccttcgg gcagcaggac ttcactgccc ggcggcaggg aggcggcgat cagtcccacg
     7201 tggacggcga cggccgtgcc gacggcgacc cggtcggcgg ggacccggac gagccgggcg
     7261 aacgaggcgc gggcggcctc gaccacgtcg aagtcgcccg ctccgtccgg ctgcccggtc
     7321 ccgctgctca gggccagcgc ccgcaccgct tcgacggccc ggcgcggcag cagaccgcag
     7381 gtcgaggtgt tcagatacgt cgtctccggc gcgaactcgg cgccacccaa agtgtccatg
     7441 ccctcaccct gggacccgcg tctgtcctgg tcaatcgcgc atgtcttacg ggtacaccca
     7501 agcgatcctt atgaacgggc gccggcctgc ggaatctcgc aggagccgtc ggtgtcgcag
     7561 gcggcgccct gtccgtcctc cgtgactccc acgaggggcg tgatcgcccg gttctgccac
     7621 gcctgctcca gggcctgggt gaagacctcg gccggctggc cgccggagac gccgtagcgg
     7681 cggtcgagga cgaagaaggg caccccggtc gcgccgagtt ccgccgcttc ccgttcgtcg
     7741 gcccgtacct cttcggcgta cgcgtcggcg tcaccgagga ccgcacgcgt ctcggcctcg
     7801 tccagaccgg cctccaccgc caggtcgacc agtgtcccgg tgtcgtagac cgagcgctcc
     7861 tcggcgaagt tcgcacggta gacgaggctc agcagctcgt cctgccggcc gcgcgccttg
     7921 gccaggtgga gcagccggtg gatgtcgaag gtgctgccgt ggtcccggtc gccgacgcgg
     7981 tagccgagcc cttcggagcg cgcgtgcgag gcgacctgct cctccatggc gagggcttcc
     8041 tgccgcgacc ggccgaactt ggcggcgagc atgtcgacca ccggggcgac gtcacccttc
     8101 gcgtgcccgg ggtcgagctc gaaggaacgg tgcaccacct cgacgtcggc ccggcgcgcg
     8161 aaggattcga gccccttctc gaaccgggcc ttgccgatgt agcaccacgg gcaggcgatg
     8221 tcgctccaga tctccacacg catgtgtctg cttctctcca ggcagggtcg tgcggagcct
     8281 ccctccgcct ctaccgcaac cgccggacgg cgcgtgccat tccccccgca ggggcgggag
     8341 gcacggcccg taccggacat catgtgacct cgtacgctca ccgcgccccc gccgagaccc
     8401 ggcgtaccac gctgagcagg tactccttgc ggttgagcgg gtcgtggtcg gtgcgggagc
     8461 gggtcggggg cgtgccccgg accgggcggt ggtggtcgaa cgccgcctcc aggacgccct
     8521 cgccgctggt gagcgtcggc aggagctgtt cgagggcgtg tacctcggcc gccgggatct
     8581 cgccctccac cacgtaggac gccccgcgcg ccgacggggt gtgcagtacg gcgcgcagcc
     8641 gggccagcgc gggcaggacg gcgccgaagg tgtcggccgg tacgtcgagg cggaagtggt
     8701 tcatcggttc gcacacgacc gtgcccgcgc gcttcagcgc ctccatcagc accagcggcg
     8761 tcagcaggcg gaagtcaccg cccgtgctcg acatgctctt gtcgaaggtg ccgtgggcgt
     8821 ggctctggcg cggcgcgtag ccggtgcggg gccggttcga cccgcagtcc gacggtcgcg
     8881 aggaacggat tgggctcctt gcccatgacc tcggcggcgc cgcccgtgcc cgcgagccgt
     8941 tcgacgcaga tggtggtggt ctcgcggaag gtgacgtcca cgccgtactc gtcggcgagc
     9001 gtcgcctgga tgacctcctt ctgcacttcg ccgtagagcg acacggagat ctcctgccgg
     9061 atctcgtcct gccgcggatt gatcagcggg tcctgctcgg cgagctgggt gagcgcggcg
     9121 tgcagggcgc ccttgtcgga accctcgcgg gggacggcgg gcgccgaccc ggtcgatctt
     9181 gttgacgaag acgagcgtgg gaatgcgcag ccggcgcagc gtgcgcatca ggacgcgcgt
     9241 ctgcgcctgg actccctcga cggcggagac gacgagcacg gcgccgtcga ggacgctgag
     9301 cactcgctcc acctcggcga tgaagtccgg gtgtcctggt gtgtcgatga gattgacggt
     9361 gacgtcgtcg atggcgaacg acacgacggc ggacttgatg gtgatgccgc gttgacgttc
     9421 gagcgccagg gagtcggtct gggtgttgcc gtcgtcgacg cggccgatct cgtcgatgac
     9481 tccggcggcg tgcagcagcc gctcggtcag gctggtctta ccggcgtcga cgtgggccag
     9541 aatgccgagg ttgagcgtgg tcaccaagcg tcaggtccct tgagtaggag gagatttcct
     9601 tcttctggat ggacttggac gctcggcgca tgacggctcc tgaggtgttc ggtggactcg
     9661 cgggccggcc ggcgggacgg ctcggtagac gtcggggagt acagcaaaac ccgccccgtc
     9721 cggcaaatga tttaccggac ggggcgggca tgttcccggt gccgcgcggg gcggtgcggt
     9781 ttacgggacg gcgctgctca cgaagcggtc ttctttacga ggcggcctgc tccgcgcggc
     9841 cgtcgacccg gcgcggcagc cccgccgggt tgtcgtcacg cagctcctcc gggagcagcg
     9901 cggcgggcgt ggactggtag gtgacggggc gcagccagcg ctcgatcgcg gtggcgccga
     9961 ccgatgtcga cgtggaggtc gacgccgggt acgggccgcc gtgctgctgc gcgggggcga
    10021 cggcgacgcc ggtgggccag ccgttgacga ggacgcggcc cgcgagcggc gtcaggtcgg
    10081 cgagcagccg cgcggcgccg gaaccggcgt cctcggcctc gccctccgcg aggtgcaggg
    10141 cggcggtgag gttgccgggg agacgggaca ggacggcgcc gatctccgcg tcggaaccgt
    10201 agcgggcgac gaccgtcacg gggccgaagc actcctccag aaggaggtcg tgcggtccct
    10261 cggcggcgag ccggcgcgcg gggacggtca gatatcccgc gctgacggtg tggtcaccgc
    10321 cgggtcccgg cgtgatcggg gcctccacgt cgggcagttc ggcccgttcc cgtacgcccg
    10381 ccacgaaggc gtcgcgcat
//
