LOCUS       NZ_NKBC01000004         9689 bp    DNA     linear   CON 17-MAR-2024
DEFINITION  Bacillus paralicheniformis strain 9-1 9-1_R1_(paired)_contig_4,
            whole genome shotgun sequence.
ACCESSION   NZ_NKBC01000004
VERSION     NZ_NKBC01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus paralicheniformis
  ORGANISM  Bacillus paralicheniformis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 9689)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9689)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009935535.1-RS_2024_03_17
            Annotation Date                   :: 03/17/2024 02:24:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,539
            CDSs (total)                      :: 4,461
            Genes (coding)                    :: 4,361
            CDSs (with protein)               :: 4,361
            Genes (RNA)                       :: 78
            rRNAs                             :: 4, 1 (5S, 16S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 68
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 100
            CDSs (without protein)            :: 100
            Pseudo Genes (ambiguous residues) :: 0 of 100
            Pseudo Genes (frameshifted)       :: 49 of 100
            Pseudo Genes (incomplete)         :: 64 of 100
            Pseudo Genes (internal stop)      :: 15 of 100
            Pseudo Genes (multiple problems)  :: 21 of 100
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:47:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 9689
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NKBC01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     gene            <1..1513
                     /locus_tag="CE036_RS03490"
     source          1..9689
                     /collection_date="2016-06"
                     /country="China"
                     /db_xref="taxon:1648923"
                     /host="Homo sapiens"
                     /mol_type="genomic DNA"
                     /note="commercial probiotic used for human"
                     /organism="Bacillus paralicheniformis"
                     /strain="9-1"
                     /submitter_seqid="9-1_R1_(paired)_contig_4"
     region          1..9689
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..9689
                     /SMILES="NC(C(C)C)C(=O)NC(CC(=O)O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..9689
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1532:>9689](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1533..>9689
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS             <3..1513
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Epimerization (41-343). E-value:
                     5.8e-170. Score: 558.6. Matches aSDomain:
                     nrpspksdomains_CE036_RS03490_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (348-499). E-value: 3.2e-49.
                     Score: 158.7. Matches aSDomain:
                     nrpspksdomains_CE036_RS03490_TIGR01720.1"
                     /codon_start=2
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020450105.1"
                     /locus_tag="CE036_RS03490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_161517308.1"
                     /sec_met_domain="Condensation (E-value: 3.3e-86, bitscore:
                     276.1, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="SRLQQHGWKLEMKDLFQHSTIGELSAYVQAADDQPIDQNPVEGEV
                     TLTPIQRWFFERKFTNEHHWNQSVMLHALTGFDPETAGKALSKLIEHHDALRMVYQRNG
                     DGIVQYNRGLEETAVRPEVIRFNESGAELEAAVLKASNRIQSSIDLTEGPLLKAAIFKT
                     DQGDHLLIVIHHLVVDGISWRILLEDFAAGYAQAEKGEPIILQDKTHSFAEYAARLEEY
                     AGSKAFAKEIGYWQEIEQAETAALPKDDEAEDKRMRHTKTAEFSLSKEETEQLMTKVHE
                     AYNTEMNDILLTALGLALKEWTGQEDFIICLEGHGREDIIDGLNISRTVGWFTSQFPAL
                     IQMRHSGDIGYQIKQIKEELRHIPNKGIGYGIYRYLTEEDKKAKPIKHDISFNYLGQFT
                     EMADSGLFTRSTLPSGDPLSPETEKPNALDIVGYIEDGILTMSIAYHSLEYKESTVAAV
                     AASFKTYLLQLIDHCLERDGGELTPSDLGDDELTLEELDKLMEIF"
     aSDomain        128..1033
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03490_Epimerization.1"
                     /evalue="5.80E-170"
                     /label="CE036_RS03490_Epimerization.1"
                     /locus_tag="CE036_RS03490"
                     /protein_end="343"
                     /protein_start="41"
                     /score="558.6"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVVDG"
                     /tool="antismash"
                     /translation="EGEVTLTPIQRWFFERKFTNEHHWNQSVMLHALTGFDPETAGKAL
                     SKLIEHHDALRMVYQRNGDGIVQYNRGLEETAVRPEVIRFNESGAELEAAVLKASNRIQ
                     SSIDLTEGPLLKAAIFKTDQGDHLLIVIHHLVVDGISWRILLEDFAAGYAQAEKGEPII
                     LQDKTHSFAEYAARLEEYAGSKAFAKEIGYWQEIEQAETAALPKDDEAEDKRMRHTKTA
                     EFSLSKEETEQLMTKVHEAYNTEMNDILLTALGLALKEWTGQEDFIICLEGHGREDIID
                     GLNISRTVGWFTSQFPALIQM"
     aSModule        128..1501
                     /domains="nrpspksdomains_CE036_RS03490_Epimerization.1"
                     /domains="nrpspksdomains_CE036_RS03490_TIGR01720.1"
                     /incomplete
                     /locus_tags="CE036_RS03490"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       143..172
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03490_0001"
                     /evalue="3.00E-05"
                     /label="NRPS-E1"
                     /locus_tag="CE036_RS03490"
                     /protein_end="56"
                     /protein_start="46"
                     /score="16.6"
                     /tool="antismash"
                     /translation="LTPIQRWFFE"
     CDS_motif       269..316
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03490_0002"
                     /evalue="3.40E-04"
                     /label="Cy2"
                     /locus_tag="CE036_RS03490"
                     /protein_end="104"
                     /protein_start="88"
                     /score="13.2"
                     /tool="antismash"
                     /translation="LIEHHDALRMVYQRNG"
     CDS_motif       509..574
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03490_0003"
                     /evalue="1.30E-11"
                     /label="NRPS-E2"
                     /locus_tag="CE036_RS03490"
                     /protein_end="190"
                     /protein_start="168"
                     /score="36.6"
                     /tool="antismash"
                     /translation="LLIVIHHLVVDGISWRILLEDF"
     CDS_motif       977..1024
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03490_0004"
                     /evalue="1.20E-07"
                     /label="NRPS-E5"
                     /locus_tag="CE036_RS03490"
                     /protein_end="340"
                     /protein_start="324"
                     /score="23.9"
                     /tool="antismash"
                     /translation="NISRTVGWFTSQFPAL"
     aSDomain        1049..1501
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03490_TIGR01720.1"
                     /evalue="3.20E-49"
                     /label="CE036_RS03490_TIGR01720.1"
                     /locus_tag="CE036_RS03490"
                     /protein_end="499"
                     /protein_start="348"
                     /score="158.7"
                     /tool="antismash"
                     /translation="IGYQIKQIKEELRHIPNKGIGYGIYRYLTEEDKKAKPIKHDISFN
                     YLGQFTEMADSGLFTRSTLPSGDPLSPETEKPNALDIVGYIEDGILTMSIAYHSLEYKE
                     STVAAVAASFKTYLLQLIDHCLERDGGELTPSDLGDDELTLEELDKL"
     CDS_motif       1070..1132
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03490_0005"
                     /evalue="3.50E-10"
                     /label="NRPS-E6"
                     /locus_tag="CE036_RS03490"
                     /protein_end="376"
                     /protein_start="355"
                     /score="32.0"
                     /tool="antismash"
                     /translation="IKEELRHIPNKGIGYGIYRYL"
     gene            1533..>9689
                     /gene="licB"
                     /locus_tag="CE036_RS03495"
     CDS             1533..>9689
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (1-29). E-value: 2.1e-15.
                     Score: 47.6. Matches aSDomain:
                     nrpspksdomains_CE036_RS03495_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (6-307). E-value:
                     2.4e-114. Score: 373.4. Matches aSDomain:
                     nrpspksdomains_CE036_RS03495_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (470-862). E-value: 2e-114.
                     Score: 374.3. Matches aSDomain:
                     nrpspksdomains_CE036_RS03495_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (965-1033). E-value: 1.9e-24. Score:
                     77.7. Matches aSDomain: nrpspksdomains_CE036_RS03495_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1049-1335). E-value:
                     3e-104. Score: 340.1. Matches aSDomain:
                     nrpspksdomains_CE036_RS03495_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1500-1903). E-value:
                     1.3e-111. Score: 365.0. Matches aSDomain:
                     nrpspksdomains_CE036_RS03495_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2010-2079). E-value: 3.4e-24.
                     Score: 76.8. Matches aSDomain:
                     nrpspksdomains_CE036_RS03495_PCP.2"
                     /NRPS_PKS="Domain: Condensation_LCL (2095-2381). E-value:
                     7.4e-102. Score: 332.3. Matches aSDomain:
                     nrpspksdomains_CE036_RS03495_Condensation_LCL.2"
                     /codon_start=1
                     /gene="licB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047: phosphopantetheine-binding domain-containing
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020450106.1"
                     /locus_tag="CE036_RS03495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lichenysin non-ribosomal peptide synthetase LicB"
                     /protein_id="WP_161517309.1"
                     /sec_met_domain="Condensation (E-value: 1.6e-90, bitscore:
                     290.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-18, bitscore:
                     54.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 3.8e-122, bitscore:
                     394.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKQKIQKVYPLTPMQEGMLYHAMLDPESSSYFTQLELFIDGEFD
                     LGIFEKSVNQLVRSYDILRTVFVHQQLQKPRQVVLAERQAIVEFEDLADLDEERQTNRI
                     DRYKQEVQAAGFNLAKDMLFKTAVFRLDRNKYRLVWSNHHIVMDGWSMGILMKRLFQNY
                     EAFRANRTVPLDQGKPYADYIKWLGRQDKDEAASYWEHRLSGLESPSVIPGGKPRPDSE
                     SYRNEEFTFVWDRNMVDALQQAANRYHVTAPNLFQAIWGAVLAKYNRTDDVVFGTVVSG
                     RPSEIDGIEHMAGLFINTIPVRLKVDQNASFAELFKQAQQHAIDAERYDYLPLYEIQKQ
                     SALDGRLISHLVAFENYPLDKELENGTIHERLGFSIKAAEAFEQTNYDFNLIVYPGAEW
                     TIKLKYNGAAFDAAFIEQAAGHLTRLAEEAIANPESKAVSADMLSKQEQQTLLAFNQTK
                     SDYPREKTIPVLFEEQVEASPDKTAVAADGRSLTYRRLNEKANQLARSLKARGLMHGNA
                     AAIMMERSLEAAVSMLAVLKAGGVYVPIDPEYPEERIRFLLEDSGAKIVLTKDSTQMSL
                     EGYEVLAVNAMDAEKEDAANLEHVNKPEDLAYYIYTSGSTGKPKGVMVEHRNIVRLVKN
                     AGYIPLKSGVKMAQTGAVSFDASTFEVFGALLNGGTLYPVPKETLLDGKQLKMFLKETG
                     ITTMWLTSPLFNQLAQQDPGMFATLNDLIIGGDALVPGIVNRVKRESPELSLWNGYGPT
                     ENTTFSTCFFIDQAYERTIPIGKPIGNSTAYIVDEYGSLQPIGVPGELCVGGDGVARGY
                     LNQPELTDEKFVGDPFAEGKRMYRTGDLAKWLPDGNIEFLGRIDHQVKVRGFRIELGEV
                     EAALARLEGISEAAAVIRENNAGENEICAYYTGARPAAQLRTELSRSLPEYMIPAHLIE
                     LESMPLTANGKVDKRQLPAPIAEETRRFEAPKNETEEILAAIWEEILGIEQPGIDDNFF
                     SIGGHSLKAMMLTAKIQEQLQKEVPIKVLFEKPTIRELAEFLQGETKEETAPITPAPSR
                     PNYPVSSAQRRMYILNQLEEASTSYNVPAVLLLEGELDKERLEAAFRALIGRHETLRTS
                     FELIDGEIVQIIHQDAVFHLTESVAEEAEAEAAIREFIRPFQLNKAPLVRAELVKLEEK
                     RHLLMIDMHHIITDGSSTGILIRDLAGFYHGEEAPAPKLHYKDFAVWQNGPEHQEKLKE
                     QEQYWLDIFKGDLPVLDLPHDFPRPSKRSFEGDRVVFGIDQKLTADIQKLLSEADATLY
                     MFLLAAFNILLSKYASQDDLIVGSPVAGRTHPDLHSIPGMFVNTLALRNRPEGEKTFKQ
                     FLQEVKETSLQSFAKQDYPLEELIEKLPLPRDTSRNPLFSVFFNMQNMEVPTLKLGDLQ
                     ISSYSVRHRTAKFDLSLEAVEHDGEIGLSFDYAVSLFKEETIRRWSGHFLNVIKKICEN
                     PGIKLRDIELLSVKERALLLEEGRHSRAESLEEQPFHVRFEEKADEMPDQPAVVCGETI
                     LTYRMLDEKANQIANVLRSEGVGKDDVVGIMLERSAEVAAAILGVMKSGGAFLPIDPEM
                     PMSRVQYMLEDSGARWLLTEPSHQAELADWYTGRLIDVRNDTLMASNKRPHPIIDGASL
                     AYIIYTSGTTGRPKGVQLEHRNLANYVSWFISEAHLSSSDKTMLLSSYAFDLGYTSFFP
                     VLLAGGELHIVPKETYTEPEAFTHYIGEQGITYIKLTPSLFHTVVQPQSFALAKGLQSL
                     RLIVLGGEKINPKDVARFHSRYPNTRFINHYGPTETTIGAIAKPVEPDMIGQLAERPTI
                     GRPISGAGALVLDASRRLVPAGAAGELYITGSGLARGYVNNRELTAAKFIENPYTPGTF
                     MYRTGDLVRRLPNGEIEFLGRTDDQVKIRGYRIELKEIEEAFIGLDDIERAVVLSFTTD
                     SGLDELCAYIQAKRQLPVSELRERLSERLPSYMIPSYFVTVDKMPLSANGKVDRSALPE
                     PQSLNGRSDSYRAPSTEIEKALCGIWEEVLGVRKVGLDDNFFDLGGHSLKGMMLTAEIQ
                     SRLGKKVPLKTLFDCPTAGLLARSIEASEGQSQQSAIQPAEKRDWYPVSSAQQRMYALH
                     HFEKNGTGYNMPSVLMMEGVLDTDRLRRAFADLVNRHESLRTAFVEIDGRTVQIVHEKA
                     DIDLKVIHIREEDAEAEINRFIRPFDLSTAPLIRAELLSISSTRHLLLIDTHHIIADGV
                     SRSLFVKEIAQLYKGTSLPEPKLHYKDYAVWQQEYDQQENIRKQEDFWLRQFKESVPEL
                     SLPLDFPRLPVQSFAGDRVHFKASKDVALKIRRLTAETNTTLNIVMLAVFNLFLSRLSG
                     QNDIVVGTAAAGRTNTDLKDMPGMFVNSLALKNHVPGQASFSEFLEEVKNNSLAALDHQ
                     DYPFEELIAKLDLPRDMSRNPMFNVMLTTEDPDKETLDLDGLTIKSYEISHAAAKFDLT
                     LGAFEKDHEIGLQFEYATDLFTKQTIERWSGYLLNLLEAVAENPDACLSELSLLDEAEK
                     RRIVQNWNETKLDVPEDKTVHELFEAQVLRTPDRGAAVYNGVEWTYKELNARANRLARL
                     LIEKGARPEQRIGIMVKPSLEMAAGVLGILKAGAAYVPIDPSYPAERIGYVLKDSGAEL
                     LLTQSGLTVPDTFTGDVIDLNGEGSILDGELYPEDDINPNAEAQPDNLAYLIYTSGTTG
                     QPKGVMVEHRSLVNLCYWH"
     aSDomain        1536..1619
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03495_NRPS-COM_Nterm.1"
                     /evalue="2.10E-15"
                     /label="CE036_RS03495_NRPS-COM_Nterm.1"
                     /locus_tag="CE036_RS03495"
                     /protein_end="29"
                     /protein_start="1"
                     /score="47.6"
                     /tool="antismash"
                     /translation="GKQKIQKVYPLTPMQEGMLYHAMLDPES"
     aSDomain        1551..2453
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03495_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="2.40E-114"
                     /label="CE036_RS03495_Condensation_DCL.1"
                     /locus_tag="CE036_RS03495"
                     /protein_end="307"
                     /protein_start="6"
                     /score="373.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIVMDG"
                     /tool="antismash"
                     /translation="QKVYPLTPMQEGMLYHAMLDPESSSYFTQLELFIDGEFDLGIFEK
                     SVNQLVRSYDILRTVFVHQQLQKPRQVVLAERQAIVEFEDLADLDEERQTNRIDRYKQE
                     VQAAGFNLAKDMLFKTAVFRLDRNKYRLVWSNHHIVMDGWSMGILMKRLFQNYEAFRAN
                     RTVPLDQGKPYADYIKWLGRQDKDEAASYWEHRLSGLESPSVIPGGKPRPDSESYRNEE
                     FTFVWDRNMVDALQQAANRYHVTAPNLFQAIWGAVLAKYNRTDDVVFGTVVSGRPSEID
                     GIEHMAGLFINTIPVRLKVD"
     aSModule        1551..4631
                     /complete
                     /domains="nrpspksdomains_CE036_RS03495_Condensation_DCL.1"
                     /domains="nrpspksdomains_CE036_RS03495_AMP-binding.1"
                     /domains="nrpspksdomains_CE036_RS03495_PCP.1"
                     /locus_tags="CE036_RS03495"
                     /monomer_pairings="Val -> Val"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1560..1598
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0001"
                     /evalue="1.10E-05"
                     /label="C1_dual_004-017"
                     /locus_tag="CE036_RS03495"
                     /protein_end="22"
                     /protein_start="9"
                     /score="17.9"
                     /tool="antismash"
                     /translation="YPLTPMQEGMLYH"
     CDS_motif       1623..1739
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0002"
                     /evalue="2.80E-13"
                     /label="C2_DCL_024-062"
                     /locus_tag="CE036_RS03495"
                     /protein_end="69"
                     /protein_start="30"
                     /score="42.1"
                     /tool="antismash"
                     /translation="SYFTQLELFIDGEFDLGIFEKSVNQLVRSYDILRTVFVH"
     CDS_motif       1956..2021
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0003"
                     /evalue="1.40E-12"
                     /label="C3_DCL_135-156"
                     /locus_tag="CE036_RS03495"
                     /protein_end="163"
                     /protein_start="141"
                     /score="39.9"
                     /tool="antismash"
                     /translation="NHHIVMDGWSMGILMKRLFQNY"
     CDS_motif       2067..2105
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0004"
                     /evalue="9.20E-03"
                     /label="C4_DCL_171-183"
                     /locus_tag="CE036_RS03495"
                     /protein_end="191"
                     /protein_start="178"
                     /score="9.0"
                     /tool="antismash"
                     /translation="PYADYIKWLGRQD"
     CDS_motif       2346..2441
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0005"
                     /evalue="6.10E-20"
                     /label="C5_DCL_263-294"
                     /locus_tag="CE036_RS03495"
                     /protein_end="303"
                     /protein_start="271"
                     /score="63.6"
                     /tool="antismash"
                     /translation="DVVFGTVVSGRPSEIDGIEHMAGLFINTIPVR"
     CDS_motif       2490..2606
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0006"
                     /evalue="3.90E-16"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="CE036_RS03495"
                     /protein_end="358"
                     /protein_start="319"
                     /score="51.4"
                     /tool="antismash"
                     /translation="QQHAIDAERYDYLPLYEIQKQSALDGRLISHLVAFENYP"
     aSDomain        2943..4118
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03495_AMP-binding.1"
                     /evalue="2.00E-114"
                     /label="CE036_RS03495_AMP-binding.1"
                     /locus_tag="CE036_RS03495"
                     /protein_end="862"
                     /protein_start="470"
                     /score="374.3"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FEEQVEASPDKTAVAADGRSLTYRRLNEKANQLARSLKARGLMHG
                     NAAAIMMERSLEAAVSMLAVLKAGGVYVPIDPEYPEERIRFLLEDSGAKIVLTKDSTQM
                     SLEGYEVLAVNAMDAEKEDAANLEHVNKPEDLAYYIYTSGSTGKPKGVMVEHRNIVRLV
                     KNAGYIPLKSGVKMAQTGAVSFDASTFEVFGALLNGGTLYPVPKETLLDGKQLKMFLKE
                     TGITTMWLTSPLFNQLAQQDPGMFATLNDLIIGGDALVPGIVNRVKRESPELSLWNGYG
                     PTENTTFSTCFFIDQAYERTIPIGKPIGNSTAYIVDEYGSLQPIGVPGELCVGGDGVAR
                     GYLNQPELTDEKFVGDPFAEGKRMYRTGDLAKWLPDGNIEFLGRIDHQVKVR"
     CDS_motif       3129..3170
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0007"
                     /evalue="2.30E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="CE036_RS03495"
                     /protein_end="546"
                     /protein_start="532"
                     /score="17.5"
                     /tool="antismash"
                     /translation="LAVLKAGGVYVPID"
     CDS_motif       3351..3410
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0008"
                     /evalue="1.90E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="CE036_RS03495"
                     /protein_end="626"
                     /protein_start="606"
                     /score="32.5"
                     /tool="antismash"
                     /translation="AYYIYTSGSTGKPKGVMVEH"
     CDS_motif       3780..3803
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0009"
                     /evalue="9.50E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="CE036_RS03495"
                     /protein_end="757"
                     /protein_start="749"
                     /score="3.2"
                     /tool="antismash"
                     /translation="YGPTENTT"
     CDS_motif       3912..4001
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0010"
                     /evalue="3.10E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="CE036_RS03495"
                     /protein_end="823"
                     /protein_start="793"
                     /score="57.8"
                     /tool="antismash"
                     /translation="PIGVPGELCVGGDGVARGYLNQPELTDEKF"
     CDS_motif       4083..4148
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0011"
                     /evalue="6.80E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="CE036_RS03495"
                     /protein_end="872"
                     /protein_start="850"
                     /score="37.3"
                     /tool="antismash"
                     /translation="FLGRIDHQVKVRGFRIELGEVE"
     aSDomain        4428..4631
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03495_PCP.1"
                     /evalue="1.90E-24"
                     /label="CE036_RS03495_PCP.1"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1033"
                     /protein_start="965"
                     /score="77.7"
                     /tool="antismash"
                     /translation="EEILAAIWEEILGIEQPGIDDNFFSIGGHSLKAMMLTAKIQEQLQ
                     KEVPIKVLFEKPTIRELAEFLQG"
     aSDomain        4680..5537
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03495_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.00E-104"
                     /label="CE036_RS03495_Condensation_LCL.1"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1335"
                     /protein_start="1049"
                     /score="340.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIITDG"
                     /tool="antismash"
                     /translation="NYPVSSAQRRMYILNQLEEASTSYNVPAVLLLEGELDKERLEAAF
                     RALIGRHETLRTSFELIDGEIVQIIHQDAVFHLTESVAEEAEAEAAIREFIRPFQLNKA
                     PLVRAELVKLEEKRHLLMIDMHHIITDGSSTGILIRDLAGFYHGEEAPAPKLHYKDFAV
                     WQNGPEHQEKLKEQEQYWLDIFKGDLPVLDLPHDFPRPSKRSFEGDRVVFGIDQKLTAD
                     IQKLLSEADATLYMFLLAAFNILLSKYASQDDLIVGSPVAGRTHPDLHSIPGMFVNTLA
                     LRNRP"
     aSModule        4680..7769
                     /complete
                     /domains="nrpspksdomains_CE036_RS03495_Condensation_LCL.1"
                     /domains="nrpspksdomains_CE036_RS03495_AMP-binding.2"
                     /domains="nrpspksdomains_CE036_RS03495_PCP.2"
                     /locus_tags="CE036_RS03495"
                     /monomer_pairings="Asp -> Asp"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4743..4856
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0012"
                     /evalue="4.00E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1108"
                     /protein_start="1070"
                     /score="54.6"
                     /tool="antismash"
                     /translation="TSYNVPAVLLLEGELDKERLEAAFRALIGRHETLRTSF"
     CDS_motif       5052..5117
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0013"
                     /evalue="5.50E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1195"
                     /protein_start="1173"
                     /score="28.5"
                     /tool="antismash"
                     /translation="MHHIITDGSSTGILIRDLAGFY"
     CDS_motif       5148..5177
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0014"
                     /evalue="1.00E-03"
                     /label="C4_LCL_164-176"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1215"
                     /protein_start="1205"
                     /score="11.8"
                     /tool="antismash"
                     /translation="HYKDFAVWQN"
     CDS_motif       5439..5528
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0015"
                     /evalue="8.00E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1332"
                     /protein_start="1302"
                     /score="47.1"
                     /tool="antismash"
                     /translation="DLIVGSPVAGRTHPDLHSIPGMFVNTLALR"
     CDS_motif       5577..5696
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0016"
                     /evalue="1.00E-14"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1388"
                     /protein_start="1348"
                     /score="46.8"
                     /tool="antismash"
                     /translation="KETSLQSFAKQDYPLEELIEKLPLPRDTSRNPLFSVFFNM"
     aSDomain        6033..7241
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03495_AMP-binding.2"
                     /evalue="1.30E-111"
                     /label="CE036_RS03495_AMP-binding.2"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1903"
                     /protein_start="1500"
                     /score="365.0"
                     /specificity="substrate consensus: Asp"
                     /tool="antismash"
                     /translation="FEEKADEMPDQPAVVCGETILTYRMLDEKANQIANVLRSEGVGKD
                     DVVGIMLERSAEVAAAILGVMKSGGAFLPIDPEMPMSRVQYMLEDSGARWLLTEPSHQA
                     ELADWYTGRLIDVRNDTLMASNKRPHPIIDGASLAYIIYTSGTTGRPKGVQLEHRNLAN
                     YVSWFISEAHLSSSDKTMLLSSYAFDLGYTSFFPVLLAGGELHIVPKETYTEPEAFTHY
                     IGEQGITYIKLTPSLFHTVVQPQSFALAKGLQSLRLIVLGGEKINPKDVARFHSRYPNT
                     RFINHYGPTETTIGAIAKPVEPDMIGQLAERPTIGRPISGAGALVLDASRRLVPAGAAG
                     ELYITGSGLARGYVNNRELTAAKFIENPYTPGTFMYRTGDLVRRLPNGEIEFLGRTDDQ
                     VKIR"
     CDS_motif       6219..6260
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0017"
                     /evalue="6.20E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1576"
                     /protein_start="1562"
                     /score="13.2"
                     /tool="antismash"
                     /translation="LGVMKSGGAFLPID"
     CDS_motif       6447..6506
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0018"
                     /evalue="1.20E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1658"
                     /protein_start="1638"
                     /score="30.1"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGRPKGVQLEH"
     CDS_motif       6891..6914
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0019"
                     /evalue="7.00E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1794"
                     /protein_start="1786"
                     /score="6.4"
                     /tool="antismash"
                     /translation="YGPTETTI"
     CDS_motif       7035..7124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0020"
                     /evalue="1.40E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1864"
                     /protein_start="1834"
                     /score="46.1"
                     /tool="antismash"
                     /translation="PAGAAGELYITGSGLARGYVNNRELTAAKF"
     CDS_motif       7206..7271
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0021"
                     /evalue="1.70E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="CE036_RS03495"
                     /protein_end="1913"
                     /protein_start="1891"
                     /score="36.0"
                     /tool="antismash"
                     /translation="FLGRTDDQVKIRGYRIELKEIE"
     aSDomain        7563..7769
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03495_PCP.2"
                     /evalue="3.40E-24"
                     /label="CE036_RS03495_PCP.2"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2079"
                     /protein_start="2010"
                     /score="76.8"
                     /tool="antismash"
                     /translation="EKALCGIWEEVLGVRKVGLDDNFFDLGGHSLKGMMLTAEIQSRLG
                     KKVPLKTLFDCPTAGLLARSIEAS"
     aSDomain        7818..8675
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE036_RS03495_Condensation_LCL.2
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="7.40E-102"
                     /label="CE036_RS03495_Condensation_LCL.2"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2381"
                     /protein_start="2095"
                     /score="332.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIIADG"
                     /tool="antismash"
                     /translation="WYPVSSAQQRMYALHHFEKNGTGYNMPSVLMMEGVLDTDRLRRAF
                     ADLVNRHESLRTAFVEIDGRTVQIVHEKADIDLKVIHIREEDAEAEINRFIRPFDLSTA
                     PLIRAELLSISSTRHLLLIDTHHIIADGVSRSLFVKEIAQLYKGTSLPEPKLHYKDYAV
                     WQQEYDQQENIRKQEDFWLRQFKESVPELSLPLDFPRLPVQSFAGDRVHFKASKDVALK
                     IRRLTAETNTTLNIVMLAVFNLFLSRLSGQNDIVVGTAAAGRTNTDLKDMPGMFVNSLA
                     LKNHV"
     CDS_motif       7887..7997
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0022"
                     /evalue="2.20E-16"
                     /label="C2_LCL_024-062"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2155"
                     /protein_start="2118"
                     /score="52.2"
                     /tool="antismash"
                     /translation="YNMPSVLMMEGVLDTDRLRRAFADLVNRHESLRTAFV"
     CDS_motif       8193..8255
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0023"
                     /evalue="5.70E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2241"
                     /protein_start="2220"
                     /score="25.3"
                     /tool="antismash"
                     /translation="HHIIADGVSRSLFVKEIAQLY"
     CDS_motif       8286..8321
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0024"
                     /evalue="2.10E-03"
                     /label="C4_LCL_164-176"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2263"
                     /protein_start="2251"
                     /score="10.9"
                     /tool="antismash"
                     /translation="HYKDYAVWQQEY"
     CDS_motif       8577..8663
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0025"
                     /evalue="2.10E-11"
                     /label="C5_LCL_267-296"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2377"
                     /protein_start="2348"
                     /score="36.2"
                     /tool="antismash"
                     /translation="DIVVGTAAAGRTNTDLKDMPGMFVNSLAL"
     CDS_motif       8718..8831
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0026"
                     /evalue="3.00E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2433"
                     /protein_start="2395"
                     /score="51.7"
                     /tool="antismash"
                     /translation="NNSLAALDHQDYPFEELIAKLDLPRDMSRNPMFNVMLT"
     CDS_motif       9357..9398
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0027"
                     /evalue="8.70E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2622"
                     /protein_start="2608"
                     /score="18.8"
                     /tool="antismash"
                     /translation="LGILKAGAAYVPID"
     CDS_motif       9600..9659
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE036_RS03495_0028"
                     /evalue="1.70E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="CE036_RS03495"
                     /protein_end="2709"
                     /protein_start="2689"
                     /score="32.7"
                     /tool="antismash"
                     /translation="AYLIYTSGTTGQPKGVMVEH"
ORIGIN
        1 aagccggctt cagcagcacg ggtggaagct ggagatgaag gacttgtttc agcactcgac
       61 gatcggagag ctgagtgctt atgttcaagc tgctgacgat cagccgatcg atcagaaccc
      121 tgtcgaaggg gaagtcacat tgacgccgat tcagcgctgg ttcttcgaac gcaaatttac
      181 gaacgagcat cactggaatc agtcggtcat gcttcacgct ttaacgggat tcgacccgga
      241 aacggcaggc aaggctttaa gcaagctgat cgaacatcat gacgcacttc gcatggttta
      301 tcaacgaaat ggagacggga ttgttcagta caacagaggg ctggaagaaa cagcggttcg
      361 ccctgaagtc atccgcttca atgaatcggg cgctgaactt gaagctgccg tgttgaaggc
      421 atcaaaccgg attcaaagca gtatcgattt aaccgaaggc ccgcttttga aagcggcgat
      481 ctttaaaacg gatcaaggcg atcatcttct cattgttatt catcatctcg ttgtggacgg
      541 aatctcatgg agaatcctcc ttgaggattt cgccgccggg tacgcccagg ctgaaaaagg
      601 ggagccgatt attcttcaag acaagacgca ctcttttgct gaatatgcgg ctcgcctgga
      661 agaatatgca gggtcaaaag ctttcgcaaa agaaatcggc tattggcagg aaatcgaaca
      721 ggcggagacg gcagcgctcc cgaaagacga tgaagcagag gacaagcgga tgcgccatac
      781 gaaaacggct gagttttccc tttcaaaaga agaaacggaa cagttgatga caaaagttca
      841 tgaagcatat aacacggaaa tgaacgacat tttgcttacg gcgttgggct tggcgctgaa
      901 agagtggacg gggcaggaag actttatcat ctgcttagag ggacacggcc gggaggacat
      961 catagacggc ttgaatattt cccggacggt cggctggttt acaagccagt tcccggcgct
     1021 gattcaaatg cgccattcag gggatatcgg ctatcaaatc aaacagatca aagaagaatt
     1081 gcgccacatt ccgaataaag gaatcggcta tggcatttat cgttatttga ccgaagaaga
     1141 caaaaaggcg aagccgatca agcatgatat cagcttcaac tatttgggcc agtttacaga
     1201 gatggcggat tcgggtctgt tcacgagatc aactttgcca tccggcgatc cgctcagccc
     1261 ggaaacggaa aaaccgaatg cgctggacat cgtcggctat atcgaagacg gcattttgac
     1321 aatgtcaatc gcttatcatt cactcgaata taaagaaagc accgtcgccg ctgtcgccgc
     1381 aagctttaaa acttatttgc tgcaattgat cgatcattgc ttagagcggg atgggggcga
     1441 actgaccccg agcgatcttg gagatgacga actcacgctt gaagaattag ataaattaat
     1501 ggagattttc taacaaaaaa acgaggtgcc ttatggggaa acaaaagatt caaaaggtgt
     1561 atcctttgac accgatgcag gaagggatgt tgtaccacgc aatgcttgat ccggaatctt
     1621 cctcttactt cacacagctg gagctattca tagacgggga atttgatttg gggatctttg
     1681 aaaaaagcgt gaatcagctc gtgcgttcat acgatattct cagaacggtt tttgttcacc
     1741 agcaattgca aaaaccgcgc caggttgtcc tggctgaacg gcaggcaata gtggaatttg
     1801 aggatcttgc ggacttggat gaggaaaggc aaacaaaccg cattgaccgg tataaacaag
     1861 aggtacaggc tgccgggttt aatttagcga aagacatgct gtttaaaact gcggtctttc
     1921 ggcttgaccg gaacaaatac cgtctcgtct ggagcaacca tcatatcgtg atggacggct
     1981 ggagcatggg gatattaatg aaacgccttt ttcaaaacta tgaagcgttt cgagcaaacc
     2041 gaacggttcc gcttgatcag ggaaaaccgt atgcggacta tattaaatgg ctcggccggc
     2101 aggataagga tgaagcggca tcctactggg aacaccgcct ttcgggttta gaaagtccga
     2161 gcgtcattcc cggcggcaaa ccgcggccgg attcagaatc gtaccggaac gaggagttta
     2221 cgtttgtttg ggacaggaat atggtagatg ctcttcaaca ggcggcaaac cgctatcatg
     2281 tcacagctcc aaaccttttt caggcgattt ggggagcggt ccttgccaaa tataacagaa
     2341 ccgatgatgt ggtgttcggc acggttgtgt ccgggcgccc gtcggaaatt gacggaatcg
     2401 agcatatggc agggctgttc atcaacacga tccctgtccg tttaaaggtc gatcaaaacg
     2461 catcgtttgc cgagctgttc aaacaagcgc agcagcatgc gattgacgcg gagcggtacg
     2521 actatctccc gctctatgaa attcaaaagc aatcggcatt ggacggccgc ttgatcagcc
     2581 atcttgtcgc gtttgagaac tatccgcttg ataaggagct tgaaaacgga acgatccatg
     2641 agcggctcgg cttttccatc aaggctgccg aagcttttga acaaacgaat tacgacttta
     2701 atttgatcgt ttatccggga gcggagtgga cgattaaatt gaaatacaac ggcgcggctt
     2761 ttgacgcggc tttcattgag caggccgccg ggcatttaac gagactcgca gaagaggcga
     2821 ttgcaaatcc cgaatcaaaa gcagtcagcg ccgacatgtt atcaaaacag gagcaacaaa
     2881 cgctgctcgc ttttaatcaa acaaaatccg attatccaag agaaaagacg atcccggtgc
     2941 tgtttgaaga acaggttgaa gcgtctcctg acaaaacggc tgttgccgct gacggaagaa
     3001 gcctgactta ccgcaggctg aatgaaaaag ccaatcagct cgcgagaagc ctgaaagcta
     3061 gaggcttgat gcacggaaat gccgccgcca ttatgatgga gcggtcgctt gaagcagcag
     3121 tcagcatgct ggcggtgctg aaagcaggcg gcgtgtacgt gccgatcgat cccgaatatc
     3181 ctgaagagcg aattcgcttt ttgctcgaag acagcggggc aaagatcgtc cttacaaaag
     3241 acagtacgca gatgtcgctg gaagggtatg aggtgctcgc cgtaaatgcg atggatgcag
     3301 aaaaagaaga tgccgccaac cttgaacatg tcaacaagcc cgaagacctt gcctattaca
     3361 tttatacatc cggatcgacg ggcaagccga agggtgtgat ggtcgaacac cgcaatatcg
     3421 tccgccttgt caaaaatgcg ggctacatcc cgctgaagag cggtgtgaag atggcgcaga
     3481 cgggggctgt cagctttgac gccagtacat ttgaagtatt cggtgcgctg ctaaacggag
     3541 ggacccttta tcccgtcccg aaagagacgc tccttgatgg aaaacagctc aaaatgttcc
     3601 tgaaggaaac cggaatcaca acaatgtggc tgacttcgcc tcttttcaat cagcttgctc
     3661 agcaggatcc gggaatgttt gcaaccttga acgatctgat tatcggcgga gatgcccttg
     3721 ttcctggaat cgtcaacaga gtcaaacgcg aatcaccgga actctcgctt tggaacggat
     3781 acgggcctac cgaaaatacc acattttcga cctgtttttt catcgatcaa gcatatgaga
     3841 gaacgatccc gattggaaag ccgatcggaa attcaaccgc ctatatcgtt gatgaatacg
     3901 gctcgcttca gcccatcggt gtgcccggtg agctgtgtgt cggcggagac ggggtggcgc
     3961 gcggctactt gaaccagcct gagctgacag atgaaaagtt tgtcggcgat ccttttgccg
     4021 aagggaagcg gatgtaccgc acgggcgact tggcaaaatg gcttcccgac gggaatatcg
     4081 aattcctcgg ccggatcgat catcaagtga aggttcgcgg cttccggatc gaattaggcg
     4141 aggttgaagc ggctttagcc cgccttgagg gaatttcaga agcggccgct gtcattcggg
     4201 aaaacaacgc cggagaaaac gagatttgcg cctattacac tggcgcgagg ccggccgcgc
     4261 agctgcggac agagctgtcc cgatcgcttc cggagtatat gattccggcc catttgatcg
     4321 aacttgaaag catgccgctg acagccaacg gaaaggttga caaacgtcag cttcctgctc
     4381 ctatcgctga agagactcgc agattcgaag cgccaaaaaa tgaaacggag gaaattttgg
     4441 cggcaatttg ggaagagatt ctcggcatcg agcagccggg aatcgatgac aacttctttt
     4501 ccatcggcgg acactcgttg aaggcgatga tgctgacagc caaaatacaa gagcagctcc
     4561 aaaaagaggt gccgatcaaa gtattgtttg aaaaaccgac gatcagagag ctggccgaat
     4621 ttcttcaagg ggaaacaaaa gaggaaaccg ctccgattac gccggcaccg tcccgtccga
     4681 attatccggt gtcgtcggcc caacggcgca tgtacatcct caatcagctc gaagaagcaa
     4741 gcacgagcta caatgtgccg gcggttctgc ttttggaagg cgaattggat aaggagcgtt
     4801 tggaagccgc gtttcgggct ttgatcggcc gccatgaaac attgcggaca tcgttcgaat
     4861 taatcgatgg agaaatcgtt caaatcatcc atcaagacgc ggtttttcac ctgacggaat
     4921 cagtggctga agaagcggaa gccgaagcgg cgatcagaga atttatccgg ccgtttcagc
     4981 tgaataaggc gccgctcgtc cgggcggagc tcgttaagct tgaagaaaag cgccatctgc
     5041 tgatgatcga catgcaccat attattacgg acggaagctc caccggcata ttgattcgcg
     5101 acctggccgg attctaccac ggagaagagg cgcctgcccc taagctccac tataaagatt
     5161 tcgctgtgtg gcaaaacggg ccggagcatc aagagaaatt gaaagaacag gaacagtatt
     5221 ggctcgacat tttcaaaggc gatctgcctg ttctcgatct gccgcacgat tttccgcggc
     5281 cgtcaaaacg cagctttgaa ggcgaccgtg tcgtcttcgg aatcgatcaa aaactgacgg
     5341 cagacattca aaagctgctt tctgaagctg atgcgacact ttatatgttc ctgttggctg
     5401 cgtttaatat cctgctttcc aagtatgcgt cacaggatga tttgatcgtc ggatcgcctg
     5461 tggcaggcag aacccatccg gatttgcaca gtattccggg catgtttgtc aatacgcttg
     5521 cgcttcgcaa tcgtcccgaa ggggaaaaaa cgtttaagca gtttttgcag gaagtcaaag
     5581 agacaagtct tcaaagcttt gccaagcagg actatccgct tgaagaactg attgaaaaac
     5641 tgccattgcc gcgggataca agccgaaatc cgctgttcag cgtctttttc aacatgcaga
     5701 acatggaggt cccgacgctg aaactcggag atttacagat ttcgtcttac tcggtgcgcc
     5761 accgcacggc gaagttcgat ctgtcgcttg aggctgtgga gcatgatggc gaaatcggtt
     5821 tgagctttga ctatgccgta tccttattta aagaagaaac gattcggcgc tggagcggcc
     5881 acttcttaaa tgtgattaaa aaaatctgcg aaaaccccgg cattaagctc cgggacatcg
     5941 aactgctttc agtcaaagag cgcgcacttt tgctggaaga agggaggcac agtcgggcag
     6001 aaagccttga ggagcagccg tttcatgtac ggtttgaaga gaaggcggac gaaatgcctg
     6061 atcagccggc cgttgtctgc ggggaaacga tcctcacata ccgcatgctc gacgaaaaag
     6121 caaatcagat cgcaaatgtg ctgcgcagcg aaggtgtcgg aaaagacgat gttgtcggca
     6181 ttatgttgga gcgctctgca gaggtcgccg cagcgattct cggcgtgatg aaatcaggag
     6241 gcgctttttt gccgattgat ccggaaatgc cgatgagcag ggtgcaatat atgctggaag
     6301 acagcggagc ccgctggctc ttaacagaac cttcccatca agcggaactc gcggattggt
     6361 ataccgggag attgatagat gtcagaaatg acacgctgat ggctagtaat aaacggccgc
     6421 atccaatcat agacggagcg agtctggcgt acatcatcta cacatccgga acgacgggcc
     6481 ggccaaaagg cgttcagctc gaacaccgga atctggcaaa ctatgtttcc tggtttatca
     6541 gtgaggcgca cttgtcatct tcggataaaa cgatgctttt gtcttcctat gcgttcgatc
     6601 tcggatacac gagctttttc ccggtgctgc ttgccggagg agagctgcat atcgtcccga
     6661 aagaaacgta tacagaaccg gaggcattta ctcattatat cggtgaacaa gggatcacat
     6721 atattaagct gacaccgtcg cttttccata cggtcgttca gccgcaaagc ttcgctttgg
     6781 caaaggggct tcagtcattg agactgattg tactaggggg agaaaaaatc aatccgaaag
     6841 atgtggcgcg gttccattcc cgctatccga acaccagatt catcaatcat tacggtccga
     6901 cggaaacgac gatcggagcc atcgctaaac cggtcgagcc ggacatgatc ggacaattgg
     6961 ccgagcgtcc gacgattgga cggccgattt cgggcgccgg ggcactggta ttggacgcct
     7021 cccgccggct tgttcccgcc ggagcggcag gcgagctgta tataacggga agcgggcttg
     7081 cgagaggata tgtgaacaac cgggaactca cggctgcgaa gtttatcgaa aatccttaca
     7141 caccgggcac attcatgtac cggacagggg atctcgtccg ccgtcttccg aatggagaga
     7201 ttgaattttt ggggcggacg gatgatcagg tgaaaatccg cggctacaga atcgaattga
     7261 aagaaatcga agaagccttt atcggacttg atgatataga gcgagcggtc gttctttcct
     7321 ttacgactga ctcggggtta gacgaactgt gcgcttatat tcaagcgaaa cgacagctgc
     7381 cggtttccga actgagagag cgtctttccg agcggctgcc gtcgtacatg atcccgtcat
     7441 acttcgtaac agtggataaa atgccgcttt cggcaaacgg aaaagtggac cgcagtgcgc
     7501 tcccggagcc gcaaagtcta aacggacgaa gcgattcgta tagagcgccg tcaaccgaaa
     7561 ttgaaaaagc cctctgcggc atttgggaag aggtgcttgg cgttcggaag gtcggacttg
     7621 acgataattt cttcgatctt ggcggacatt cattaaaagg aatgatgctg acagcggaaa
     7681 tccaatccag gctcggaaaa aaagtaccgt taaaaacgtt gttcgattgt ccgaccgccg
     7741 gcttgctcgc ccgcagtatt gaagcatcag aaggacagtc acaacaaagc gcgattcagc
     7801 ctgccgaaaa acgagactgg tatccggttt catccgctca gcaacggatg tatgccctcc
     7861 atcattttga aaagaacgga acgggctaca acatgccgtc tgtcctcatg atggaaggcg
     7921 tgcttgatac ggaccgttta agacgggcgt tcgccgactt ggtgaaccgc catgaatcat
     7981 tgcgaaccgc atttgttgaa atcgatggcc gtaccgttca aattgtccat gaaaaagcgg
     8041 acattgactt aaaggttatt catattcgtg aagaggacgc agaagcggaa atcaaccgct
     8101 ttatcagacc gtttgatctc agcaccgccc cgctgatcag agctgagctg ctttccatca
     8161 gctctacgcg ccatctgctt ttgattgata cacatcatat tattgcggac ggcgtttcca
     8221 gaagcctttt cgtcaaagaa atcgcacagc tttataaagg cacttcgctc cctgagccga
     8281 agctgcacta caaggattat gcggtgtggc agcaagaata tgaccagcaa gaaaacattc
     8341 ggaaacagga agatttctgg ctccgtcagt ttaaggaaag cgtgccggaa ctcagccttc
     8401 cgctcgactt cccgcgtctt cctgtccaaa gctttgctgg tgaccgtgtt cactttaaag
     8461 catcaaaaga cgttgccctt aaaatccgcc gtttgaccgc ggaaacaaac acgacgctga
     8521 atattgtgat gctcgccgtt tttaacctgt ttttaagccg tctatccggt caaaacgata
     8581 ttgtcgtcgg tacagcggca gcgggccgaa cgaatactga tttgaaagac atgccgggaa
     8641 tgttcgtcaa ttcgttggcg ctgaaaaacc atgtgcctgg tcaagcatca ttcagcgagt
     8701 ttttggaaga ggtgaaaaac aacagcctcg cagccctcga ccatcaggac tatccgtttg
     8761 aagagctgat cgccaagctt gatttgccgc gcgatatgag ccggaatccg atgttcaatg
     8821 tcatgctgac aacggaagat cctgataaag agacgctcga tttagacggt ctgacaatca
     8881 agtcgtacga gatttcacat gctgctgcca agttcgacct gacacttggg gcttttgaaa
     8941 aagatcatga aattggtctt cagttcgaat atgcaacaga tttgtttacg aaacaaacga
     9001 tcgagcgctg gagcggatat ttgcttaatc tgctcgaagc ggttgccgaa aatccggatg
     9061 cctgcctgtc agagctttca cttctggatg aagcggaaaa acggcggatc gttcaaaatt
     9121 ggaatgagac gaagcttgat gtgccggagg acaaaacggt ccatgagctg ttcgaagcgc
     9181 aagtcctccg cacgcctgac cgcggggcag cggtgtacaa cggcgtggag tggacataca
     9241 aagagctgaa cgcgcgcgcg aaccgcctgg cccggctgct gatcgaaaaa ggggcccgcc
     9301 ctgaacagcg gatcgggatc atggtcaagc cttcgcttga aatggccgct ggcgtgctcg
     9361 gaattttgaa agcgggagcg gcctatgtgc cgatcgatcc tagctatccg gccgagcgga
     9421 tcggatacgt gctgaaagac agtggcgcag agctgctttt gacgcaaagc ggattaacgg
     9481 tgccggacac atttaccgga gacgtgatcg atttaaatgg agaaggctcc attctggacg
     9541 gcgagcttta tccagaggat gacatcaatc caaacgcgga agctcagcct gacaacctgg
     9601 cctacttgat ctacacatcg ggcacgacag gccagccgaa aggcgtcatg gtcgaacatc
     9661 ggtcgctcgt gaatttgtgt tattggcat
//
