LOCUS       NZ_NKBC01000001        25468 bp    DNA     linear   CON 17-MAR-2024
DEFINITION  Bacillus paralicheniformis strain 9-1 9-1_R1_(paired)_contig_1,
            whole genome shotgun sequence.
ACCESSION   NZ_NKBC01000001
VERSION     NZ_NKBC01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus paralicheniformis
  ORGANISM  Bacillus paralicheniformis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 81173)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 81173)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009935535.1-RS_2024_03_17
            Annotation Date                   :: 03/17/2024 02:24:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,539
            CDSs (total)                      :: 4,461
            Genes (coding)                    :: 4,361
            CDSs (with protein)               :: 4,361
            Genes (RNA)                       :: 78
            rRNAs                             :: 4, 1 (5S, 16S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 68
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 100
            CDSs (without protein)            :: 100
            Pseudo Genes (ambiguous residues) :: 0 of 100
            Pseudo Genes (frameshifted)       :: 49 of 100
            Pseudo Genes (incomplete)         :: 64 of 100
            Pseudo Genes (internal stop)      :: 15 of 100
            Pseudo Genes (multiple problems)  :: 21 of 100
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:47:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 25468
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NKBC01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     rRNA            complement(<1..220)
                     /db_xref="RFAM:RF00177"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="CE036_RS00005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /product="16S ribosomal RNA"
     gene            complement(<1..220)
                     /locus_tag="CE036_RS00005"
     region          1..25468
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..25468
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-ii"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..25468
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[8653:15468](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8654..15468
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..16833
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..16833
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6218:6833](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(6219..6833)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     misc_feature    327..343
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.79"
                     /tool="antismash"
     misc_feature    421..437
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 23.12"
                     /tool="antismash"
     gene            559..1323
                     /gene="pdaB"
                     /locus_tag="CE036_RS00010"
     CDS             559..1323
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pdaB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003235130.1"
                     /locus_tag="CE036_RS00010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family sporulation
                     protein PdaB"
                     /protein_id="WP_020449906.1"
                     /transl_table=11
                     /translation="MNHFYVWHMKRIKQLIIIMIAAFATASFFYVQNLLPLPVFSTESG
                     AKAVYRGDSDTNEVALTFNISWGDQKAMPILDTLKANGIKDATFFLSASWAERHPDVVE
                     RIRKDGHQIGSMGYAYKNYSQMKKSEIKKDLTKAQNSFQKLGLEDLTLLRPPTGQFNKD
                     VLDVAKQYGYTVVHYSINSDDWTNPGVQKIVQNVNETVSAGDIVLFHASDSAKQTKEAL
                     PEIVHHLRSKGLKNVTVSDLIANTDAKSSEVK"
     gene            complement(1332..1931)
                     /locus_tag="CE036_RS00015"
     CDS             complement(1332..1931)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178407.1"
                     /locus_tag="CE036_RS00015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="KinB-signaling pathway activation protein"
                     /protein_id="WP_020449905.1"
                     /transl_table=11
                     /translation="MKSRNLVRFFFSVLGVGALTTSIVGFAIEWGRYKELFLSFEVLEI
                     LSVLFWFIGVGMIFSVIAQMGFVIFLTIHRFALEIFRSHSLWNSIQLFLIVFVAFDLVY
                     LRFLFFEKEGGSIIPYIWLPLFILAVSIAAAYAKQKQSSKKTFVSALFLMFVFTVMEWF
                     PALRVNEEDWLYLMLLPLLACNAFQLLMLPKFQARA"
     gene            2045..2626
                     /gene="gerD"
                     /locus_tag="CE036_RS00020"
     CDS             2045..2626
                     /GO_process="GO:0009847 - spore germination [Evidence IEA]"
                     /codon_start=1
                     /gene="gerD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009330340.1"
                     /locus_tag="CE036_RS00020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="spore germination lipoprotein GerD"
                     /protein_id="WP_020449904.1"
                     /transl_table=11
                     /translation="MFKTTMLSISCFLFLSVTACAPTDQAAEMDYDQTKKMVVDILKTD
                     DGKKAIQEILNDDKLNETLVMDEKTVKETVEKTMTSKKGAEFWKKVFEDPKFAEGFAKT
                     LQNEHEKVLKKLMKDPEYQKMLMQVMQDPEMTKKYGELVRSQEFRTHLQEVISDTLSSP
                     LYRKQFEEELKKAASESMKEEMKGGEEKQS"
     gene            complement(2680..3741)
                     /locus_tag="CE036_RS00025"
     CDS             complement(2680..3741)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1157: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178403.1"
                     /locus_tag="CE036_RS00025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Mrp/NBP35 family ATP-binding protein"
                     /protein_id="WP_020449903.1"
                     /transl_table=11
                     /translation="MLREDDVKKIVGDLDEPFLHKPLRELDAVKEIKIKPEKRHVSVKV
                     ALAKTGSAEQMQLQQEIVIRLKEAGAETVGLRFEELPEEVVMNNQESAQGQDQSLLNSE
                     KQPVFLAVASGKGGVGKSTVSVNLAVSLARIGKKVGLIDADIYGFSVPDMMGITVRPTI
                     EGEKVVPVERFGVKVISMGFFVEDNAPVIWRGPMLGKMLNNFFHEVEWGDVDYIILDLP
                     PGTGDVALDVHSMLPSCKEVIVSTPHPTAAFVAARAGAMALKTDHEILGIVENMAYYES
                     VKTGEKEYVFGKGGGEKLAEELGVPILGKIPLKQPDWDDSEFAPSVYDESHPTGAIYLD
                     IAKKIDESIGVKA"
     misc_feature    complement(3795..3815)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.45"
                     /tool="antismash"
     gene            complement(3827..4540)
                     /gene="cwlD"
                     /locus_tag="CE036_RS00030"
     CDS             complement(3827..4540)
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cwlD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388034.1"
                     /locus_tag="CE036_RS00030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetylmuramoyl-L-alanine amidase CwlD"
                     /protein_id="WP_020449902.1"
                     /transl_table=11
                     /translation="MKKKIKWLGFLLGFVVLLCLFQYQFHNDDSWRSWNLPLSGKIIYI
                     DPGHGGADGGASSGELLEKDVALEVSLRIRDYLQEQGALVLLTREDDHDLAPEETKGLS
                     RRKAEDLRKRVDVINNSEADLYLSIHLNAIPSARWSGAQSFFYGQYEENERAAKFIQDE
                     LRHNLENTTRKAKRIHGIYLMQNVKKPGALVEIGFLSNPKEAKQLAKPKYQDKIAASVY
                     KGVLRYFTEDRDPPE"
     gene            complement(4625..5068)
                     /locus_tag="CE036_RS00035"
     CDS             complement(4625..5068)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178399.1"
                     /locus_tag="CE036_RS00035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YbaK family protein"
                     /protein_id="WP_020449901.1"
                     /transl_table=11
                     /translation="MGTVVSFNNEKQKKQINLEKKLLRELSLEKMLNSAEECFAPLFHF
                     FSKHTDILYDGCIDFAIEAYLLGAEYGKFGYHGEPVQRAMVRSEKEEKQLLHELYEYAV
                     SWSEAFNIQAAHEPLYYACEYFIQSWWKEGFSERERRFKLRLR"
     CDS             5089..5262
                     /gene="allorf_05089_05262"
                     /locus_tag="allorf_05089_05262"
                     /protein_id="allorf_05089_05262"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MYCAVRSRKSCFSKEGKRRKKPKILGEVSFSSFMRAIHKVFCKGK
                     SVFSLFLFSILV"
     CDS_motif       5089..5181
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MYCAVRSRKSCFSKEGKRRKKPKILGEVSFS"
                     /locus_tag="allorf_05089_05262_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5182..5262
                     /prepeptide="core"
                     /locus_tag="allorf_05089_05262_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.70"
                     /molecular_weight="2933.6"
                     /monoisotopic_mass="2931.7"
                     /core_sequence="SFMRAIHKVFCKGKSVFSLFLFSILV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MYCAVRSRKSCFSKEGKRRKKPKILGEVSFS"
                     /leader_location="[5088:5181](+)"
                     /alternative_weights="2951.6"
                     /alternative_weights="2969.6"
                     /alternative_weights="2987.7"
     gene            complement(5350..6075)
                     /locus_tag="CE036_RS00040"
     CDS             complement(5350..6075)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006640359.1"
                     /locus_tag="CE036_RS00040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_006640359.1"
                     /transl_table=11
                     /translation="MTVRICVIDDDQDILDFFKEVSDSISHARFELITREISELISHLE
                     SVNEVDLVIIDINLKQSSGFDLAEYLKEYYPSISIMFMSSYTEYALDGYKFYPIDFLVK
                     PINILRLKSAVELLRNHKAFSKRNNKKIGISSSGKIHLVDVDSILYIEKVGRKSCINLE
                     NGKIIKSSQCLMTLEEMLKGSNFFRTHQSFLVPLDKIEEIIQDTYMKSYNLKIKNCKKI
                     INVSRNKYRELKELLTAVI"
     gene            complement(6219..6833)
                     /locus_tag="CE036_RS00050"
     CDS             complement(6219..6833)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016526.4"
                     /locus_tag="CE036_RS00050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_020449900.1"
                     /sec_met_domain="AgrB (E-value: 1.6e-29, bitscore: 95.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKFTPNYLSKKISEQIIYYNPDFRSRQDSIRYGLEWMLAAINQI
                     LLVFIIACYFDCVIQAMVILSAGGFLRMFSGGSHFKGYYYCLFFSTFQIMVITYISIEF
                     AFHFSRGMKWMLIGLIVLSFFIFLKKSPKLHKKMQVFSPQQRTEIKYRSICVFLGLMLV
                     SLLVDSQLQYGIWIAMIMQSITLTDSWHKIILSFDKRFNKK"
     gene            complement(6826..8139)
                     /locus_tag="CE036_RS00055"
     CDS             complement(6826..8139)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="CE036_RS00055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_080131199.1"
                     /transl_table=11
                     /translation="MYILGVLVMDLPTQLIGGMLETFLIITIGISLLNVSYKNKFFSLL
                     LISLYGSIVLYLVKSSFPPLLYLSIMVLAISLPVSLFLNLRILLSIIGVLLGAVCLLVS
                     EVIGFAMLRVAEPVLNVKEGSLGTALPHFCILLFMLFLIRKKRVVLISPKKQVKDLDIK
                     LYMILILSFSLLLLYYFIIYKNQKVEGFINLFWSIALVSLTFFTLIIMRRIFYKNLRNA
                     ENSLEEQYEEVGKYIHFIKKHNHDQGHHLIAIQQMLNKGQYEETKHYLSDVMKDSALIS
                     DILPIHSIALSALLLSYKDKALKEDIRIHYKISDSLRDFPCKLFETNKIFGNLIMNAVE
                     AVKELGDIPERTVYVQIDSGEGYYRIDVGNFGDVERFAEVVDRIFEEGFSTKGKKGRGY
                     GLHIVKSVVEKHQGFIFPEIIDRMIVFKVRIPKELGDG"
     gene            8342..8548
                     /locus_tag="CE036_RS00060"
     CDS             8342..8548
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="CE036_RS00060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_020449898.1"
                     /sec_met_domain="mature_ha (E-value: 2.8e-14, bitscore:
                     45.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKIEAWKNPVARMNSQIVSPAGDLMDELSDSEMEMLAGGCEWYN
                     ISCQLGNKGQWCTLTKECQRSCK"
     CDS_motif       8342..8461
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSKIEAWKNPVARMNSQIVSPAGDLMDELSDSEMEMLAGG"
                     /locus_tag="CE036_RS00060_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8462..8548
                     /prepeptide="core"
                     /locus_tag="CE036_RS00060_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.80"
                     /molecular_weight="3238.7"
                     /monoisotopic_mass="3236.5"
                     /core_sequence="CEWYNISCQLGNKGQWCTLTKECQRSCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSKIEAWKNPVARMNSQIVSPAGDLMDELSDSEMEMLAGG"
                     /leader_location="[8341:8461](+)"
     gene            8654..11971
                     /gene="lanM"
                     /locus_tag="CE036_RS00065"
     CDS             8654..11971
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="CE036_RS00065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_223254889.1"
                     /sec_met_domain="mature_ha (E-value: 2e-06, bitscore: 20.2,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 3.8e-109, bitscore:
                     357.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.7e-68, bitscore:
                     222.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNPAGDLMDKLSDSEMEMLAGGCAWCNISCQLGNKGSWCTLQYK
                     ILVESGRHFAGRVHLIQKKVRSETMDSMLKGTDSERLEQIKFWSRFFYNNEEYMKRSLN
                     EISGINIDHILALKFGGKKSAVENVHPWFDDWDLILKGALDPLPARQTEQNKKFGTFID
                     HFLKLAFSKLKTLYIHNHSFDFSENELYSDLLEQMNDDIYSICHKTLVLELNVYREQGL
                     LKGSTPEERYDYFEHEILTDKKFLSSFGSEYQSLISLLIHKVNSSVSFIRDIVEHLEND
                     WPVLIKTFPKIGRLRKIHLGKGDTHDNGKSVSILEFEGGQSLVYKPRPLDADQQYQKLL
                     SWLNAQENNIPNFYKMKVVNADDHGWTEFIQYKACQSAEEVKDFYKRMGAQLAVLYVLN
                     ATDFHYGNIIAMGGHPVFVDMESLFHQNIYDDSYSKEALGQADKMLSKSIMASGMLPNL
                     LYQRKDRNKSGVDLSGLGGKGNQRLPFEVAQIVDKGTDQAYLKKGIAFLEAGLNLPSYN
                     GKFVNLHDYLSEIVEGFTAVYRFMAANKVELTSQLQGFKQVRVRTILRPTAVYGEFLRS
                     LVHPDLLRDPVDQEVFLHRLWLKCLQVPKMESIIIDEMEDLRRHDVPLFTTRPGERHLW
                     SSNGRVIRDFFLSPAFDLVLEKIRSLDEKDLYGQLQVLHMVMLASSADHYADVEKIDPF
                     WNKTAPAKEDFLEQAVDIGNYLLKTKIQGVNRNKKDLTWISTVLEGNNEVIWKISPVGL
                     DLYNGNSGIALFLAYLSYFTGEQRFKEAAEQAIVPILNDMKKFSENPTWSLGAYSGVGG
                     NLFTTILLAELWNDSSLHQQVEKALPGYIAMINEDTIFDYIGGATGALDILLCIFHRTG
                     SIQAVKGAISCGKHLMKHGRVMKSGGMGWPSVLDGSVLTGYSHGTGGTAAALSSLNYWT
                     ENKAILPYISKALEYERTFYDEKEKNWRTPGRDTSSYAWCHGAPGILLSRLRLKENGWT
                     DPLLDREIEVALETTLHKGFGNNRSYCHGDFGQLEILLYAKQVLQDRELDVYIESVRSQ
                     LLEIVKQKMWNYGISRGTEAKGLMTGLAGIGMGLLKQYDSEAVPNILNLENKLLERR"
     gene            11977..12192
                     /locus_tag="CE036_RS00070"
     CDS             11977..12192
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003186379.1"
                     /locus_tag="CE036_RS00070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_020449896.1"
                     /transl_table=11
                     /translation="MSHREMAAIYRDANKRANLEFSNPVGEVNEEELKNLAGAADVTPH
                     TTPSSLPCGTLVTAVWCPSNACTSDC"
     CDS_motif       11977..12093
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSHREMAAIYRDANKRANLEFSNPVGEVNEEELKNLAGA"
                     /locus_tag="CE036_RS00070_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12094..12192
                     /prepeptide="core"
                     /locus_tag="CE036_RS00070_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.70"
                     /molecular_weight="3055.4"
                     /monoisotopic_mass="3053.4"
                     /core_sequence="ADVTPHTTPSSLPCGTLVTAVWCPSNACTSDC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSHREMAAIYRDANKRANLEFSNPVGEVNEEELKNLAGA"
                     /leader_location="[11976:12093](+)"
                     /alternative_weights="3073.4"
                     /alternative_weights="3091.4"
                     /alternative_weights="3109.5"
                     /alternative_weights="3127.5"
                     /alternative_weights="3145.5"
                     /alternative_weights="3163.5"
     gene            12376..15468
                     /locus_tag="CE036_RS00075"
     CDS             12376..15468
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="CE036_RS00075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_020449895.1"
                     /sec_met_domain="DUF4135 (E-value: 9e-107, bitscore: 350.1,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7.9e-68, bitscore:
                     221.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVAKMKDMFSRSAYLNERKITGTKTPAVNIKEFNKWKRAIPEGM
                     LEKRLKMDRLTIEQLMQYIEEKDNPVVEKELPWTTVFEKVMHTYKSTPLDYTSFQALVD
                     PFIQYAKKRLADALRHINTSLVNLETIIKSIANTLYERLHSMLMKCVILEVNIARKVGM
                     LEGETGEERFEHFMRQLNEDHELRMEFFGNYPVLSRLMTESMQNTLDVTVELIQRFVKD
                     HESIKYQFGNRLHRLERLKMGLGDTHQNGRTVALLEFETGNKLVYKPRQILIDKIFEAL
                     LSWLNGKGLQYPLQSAKSLDCRTYGWQEFVPYEKCTHEDEVSRFYYRQGAYTALFYILG
                     SSDFHAENIIAHGEYPVPIDLETLFSRNLEMMKQLRVQSRLALELNDSVYSTLMLPLPS
                     FEHSIIDFDLSALGAGQNQVSKKIKSLHLEGEGTDEIKMTRVPAKSGEYKNKPMFKGKT
                     MSAFDYSAELETGFSDMYKLFLRHKEEFMSVDGPLQPYGKAHVRQVFRPTHVYMEFLHN
                     SLHPDYVQNGLDRVQMFDILWQVTNQSSKFEELVKHETKDLLRHDVPYFYFTLNSRDLY
                     NSNGHLISSFFSETGFESIFKRINKLSKSDLEKQTQYLRWSLASMLGDVWKFHQTVPTL
                     PKRKGNLSPSSIIKEALELGRQLKDRAIIEDNLEVNWLGLNLNKETGVNVSVKSSDLYD
                     GLLGYALFLAYLARETNNCQYEKLSRGAIKTVIRKAGDKPLNPSVSAFSGEGAFLYGLV
                     HLGLLWNDRELIRRAKERLPSLHDIIRDEKNPDFSGGLAGFIVMSLNIYQETGDKDYLD
                     MAQFAGDRLMQLLTEIDEGTGLAHGASGYAWALGSLGKVTGKKIYKDKTEKLLLYENTF
                     YDPATGNWDSAAASENQKRKRVYWCHGAPGIALSRLMLKNTSNLELIAKDLDISLKTVI
                     CEGVIESHCLCHGTMGNADILLTASQELNDVKLEKKARDLVDIVLSQKKTYGWRFGLDP
                     RAEMDGFMLGRTGIGYSLLRFKNPEIPSVLALELPKGGAVC"
     gene            15462..17612
                     /locus_tag="CE036_RS00080"
     CDS             15462..17612
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010334373.1"
                     /locus_tag="CE036_RS00080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_020449894.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.2e-42, bitscore:
                     135.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKKKKLFPTRRRVPFIEQMQQTECALCCIAMISSYYKNDLSMYE
                     VRERMGNGRDGTTLFHLKKLAEQLNFDTKSYKADSRQLGTLILPAILYWENNHFVILEK
                     VAQQAYTIVDPGSGRRKLKEKEFTEKYSGYVLTLYPNKNFERRSRKNVWASFSYLVTNR
                     PKIFISILFLTFLLQMFTVAMPIFIQFVIDKIIVPDYRDLLNIFLAGIGGLILFNTLFT
                     FLRGRILITLHNALDYEIQTRFFSHLLRLPYQFFLLRSFGDLLFRANSMKVIRDQLANQ
                     VVKGLLDSAVLLVILLYMFLQSPLMVFIVALIASTNVILIAVSQRYLAETNQMEIKEHS
                     EVQGAQTEMLYGIFGVKTSGVESKIYNRWLQRFRNLLSAYRKKEIVLNRVNTASNTMQL
                     MAPLILLWVGAHQVFAGSITLGVLVAFHAISNQFFMLSGNIVQTINSFILTTSYLKRVE
                     DVLDAPGEMEGDKMKKTLEGNILLKNVTFSYSKYSENVIHNVTLDIKKGQKVALIGQSG
                     SGKTTLANMIIGLFAPSSGDIYYDGVSMKELDLGHLRRQIGTVPQNVMLFNRSIYDNII
                     LHNPEASPEEVIEAAKAAQIHEEIMKMPMQYHTMVSEMGMNISGGQRQRIALAKALLGK
                     PSILVLDEATSSLDHLNESKIDEYLSDINCTRIVIAHRLTTVMNCDMIVVVDNGRIIES
                     GTHHELLKKSSFYSEFYKEMIS"
     gene            17731..18033
                     /locus_tag="CE036_RS00085"
     CDS             17731..18033
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006640355.1"
                     /locus_tag="CE036_RS00085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020449893.1"
                     /transl_table=11
                     /translation="MNIEQIAVYGNSIGGVVILACLAIIWIVSRRMGRDERSEAIFLRV
                     YSSMFYVLAALIALSIFFGFGHDISGLMYQKITSLMFALSVIFGTIYLFILKRKY"
     gene            18086..19006
                     /locus_tag="CE036_RS00090"
     CDS             18086..19006
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006640354.1"
                     /locus_tag="CE036_RS00090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_020449892.1"
                     /transl_table=11
                     /translation="MDEHQYILETRQLTKTYRKTDVVKNVNLCIQEGEIYGFLGPNGAG
                     KTTTIRMLLGLINPTKGETRIFGKDLKSNRLDILRNVGSLVESPSYYPHLTGEENLEAI
                     RKILNVPKSNIDDVLEMVRLTKMADKKAGEYSLGMKQRLGIAAALLGYPKLVILDEPTN
                     GLDPAGILEIRELILRLPSDYGITVMISSHLLSEIEQVATQVGIIANGEMLFQDAIGEL
                     RSKADTKIVFSTSDTDGALDIFSREGVEAVKTQRGLMIEDRTDMEISRLARKLFENEID
                     IFRIYDESKSLEDIFLDMTKGGETL"
     gene            19003..19710
                     /locus_tag="CE036_RS00095"
     CDS             19003..19710
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006640353.1"
                     /locus_tag="CE036_RS00095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_020449891.1"
                     /transl_table=11
                     /translation="MISELLKSEILKIRKLTWVIVIFGPLGVVAMQGANYALRFDYLMS
                     RNPDKWLFLLENIHAYWPPSLLLGTTMINSLLAGMEHHANMWKKLFSLPVKQWKVYQSK
                     IIIIITMMLISTAILPAGTYVLGRLLGFSETFPLGDALMMSFYTLFAALPFVFLQFWLS
                     VKYSNQGIALTIGIASAVFIMYAHGLPEWMPWKWPLLIDGIGQSTLSVIKGLAVGLLIY
                     LFALLSLSRKDVA"
     gene            19712..20452
                     /locus_tag="CE036_RS00100"
     CDS             19712..20452
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006640352.1"
                     /locus_tag="CE036_RS00100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_020449890.1"
                     /transl_table=11
                     /translation="MFYQLLNSEWLKLKNSKIWFIVLASPALSAVIGFFPLFSIGSSKW
                     LALSTQMILTHSALFLPLLTGVLAALLCSNEHAHGGWKQLLTLPVSRVQVYAAKYVIIM
                     ILLLFTQLFFLIGIWFVGSVQGFGSPFPWYSLVMSCLMGWLSCLPLAALQFWLATYFKS
                     FAGPSTVNVMLTLPAILIANSELLGPLYPWSHPMLSMTQAFSAAMGGDAGFLANESAFY
                     PTLIVSFVAFIGGGALYFHKKEWT"
     gene            20476..20709
                     /locus_tag="CE036_RS00105"
     CDS             20476..20709
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006640351.1"
                     /locus_tag="CE036_RS00105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_020449889.1"
                     /transl_table=11
                     /translation="MNAENKQKKKLTNRLPEWRARTKMTQQQLAERAGVSRQTIISIEK
                     MKYTPSLTLAFEIAHAFGCSIDDVFEYNKEDV"
     gene            20734..21639
                     /locus_tag="CE036_RS00110"
     CDS             20734..21639
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006640350.1"
                     /locus_tag="CE036_RS00110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_020449888.1"
                     /transl_table=11
                     /translation="MIIETKGVTKTYNRIDVVKDAGLLVPEGEVYGFLGPNGSGKTTMM
                     RMLMGLIRPDSGEILMFGNRMPDNRISILAKTGALIEKPSYYEHLDGRDNLRILATLRG
                     ISDNRAIDWALERVGLHRVGSKKVKSYSLGMKQRLGIASAILHNPRLLLLDEPTNGLDP
                     EGIHEIRELIRELPKKEGATVLVSSHLLGEVEQMANRIGVIYHGNLLFQGEMATLLSDQ
                     KSGYIIRSTESGKIIDILHEHGLETRVDRAEQVQVSGAVKDKIEGILIENEITDFHINE
                     SPGTLEEAYLQLIRSSEVSV"
     gene            21636..22334
                     /locus_tag="CE036_RS00115"
     CDS             21636..22334
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CE036_RS00115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020449887.1"
                     /transl_table=11
                     /translation="MKSVFAAEWRKQRPAALLLPLCSGPLLIFAACWTMMLYLTKNGRT
                     AEQAFRVLYELCTLTWSYLIIFVVMMFTLLVSGVEHKSGMWPVLLSTPHAKWKHFFVKV
                     ILATLLVQLFGLILWLLMGGLGFIFGGTFPEPLLYTAFLFALPFVVFQTSATVVVENPY
                     ISVSIGMAVFLFHAVLPYWWLPWGPLAELLRAGTQANSLLPVLMLVSTLGYGMLSLLIF
                     YQKTFSSGGE"
     gene            22336..23094
                     /locus_tag="CE036_RS00120"
     CDS             22336..23094
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006640348.1"
                     /locus_tag="CE036_RS00120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_020449886.1"
                     /transl_table=11
                     /translation="MASFQQAFSAEWIKIRKMKIWLMIIILVVLPVIYGWIIHTKIMIG
                     KYVYNEANSWQILMMMTQMFYGTVFFPIIISLITGTMSKYEKQANNWEHLLMIPAKGTV
                     FFLSKMAWTVIIILSAQLLMFGLQIVLGYASGYTDQIPIGTYLSAVILGTAGATSLGTL
                     LFYFYLRMKSARTALMISIFLSFPSFLAFSNNTDSLIPVLYPWALPLYGMTNVYAGTDR
                     LAVFFIVCVAMTALFSLLSIKKLNNRTFYS"
     gene            23174..24577
                     /locus_tag="CE036_RS00125"
     CDS             23174..24577
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="CE036_RS00125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_033155051.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.2e-44, bitscore:
                     144.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIKRIHILLLCLLVVIIFALPGQASANDSQLDRYTIYLESPAHH
                     DDWVKTLNERNIKLVYSVEEIGLYQIEGRQKEVQELAAEINYINSHNQSVAMQPASLHN
                     TAPAEATIFGGTPTLWDDFQWDMRKATNNGQTYQITEGSKNTIVGIIDSGIDMNHPDLK
                     ENILSVRNFVPKGGLRGQEPYEKGDINDSTDYLGHGTFVAGQIAANGLMKGIAPETGIR
                     SYRVFGGKSADTVWIIDAIIQAAIDDVDIINVSFGTFLVKQNRKNKQMPDTNDLAEIKA
                     FKKAVSFAHKKGSAVVASIGNEGLDLKDKNAVFEYWRSTKQEDLSADGKVILIPAQLPN
                     VVTVSSIGPSGMRSVFSNYGKNVVDIAADGGDLRLLNEVGEDRYYGEGLFRQEYILGAA
                     PGVTYTFSIGTSIAAPKVSGALALLIDQKQLHDKPDKAVKILLKNADRNADKIDTGAGV
                     LNVYRALTD"
     gene            complement(<24942..>25025)
                     /locus_tag="CE036_RS22655"
                     /pseudo=""
     CDS             complement(<24942..25025)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003225846.1"
                     /locus_tag="CE036_RS22655"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVYFSFLLEADPEYRSILKRALLLTRDA"
ORIGIN
        1 taaaagccac cttttataat taaaccatgc ggttcaatca agcatccggt attagccccg
       61 gtttcccgga gttatcccag tcttacaggc aggttaccca cgtgttactc acccgtccgc
      121 cgctgaccta agggagcaag ctcccatctg tccgctcgac ttgcatgtat taggcacgcc
      181 gccagcgttc gtcctgagcc aggatcaaac tctccatgaa gtttgataat gactacgcac
      241 attcgcatgt gcgatttatt taatgaatta acaggtacgt tttgtcttgt ttagttttca
      301 aagatcattt ccgcttcgtt cagcggcttt aataatataa catcaagccc acatatttgt
      361 caataacttt tttcaaaatt atttgttgga gctttttcat gtcagctgtt tatcagcgac
      421 gaataataat ataacatgtt aattcaaatc tggtcaaccc tctttttaat ttttttctta
      481 agatgaatta ttgttatgtt ctattttaaa caagcatagg atgaatacaa agcagcatgg
      541 acaaggagga gtttctctgt gaaccatttt tatgtgtggc atatgaaacg gattaagcag
      601 ttaatcatta ttatgatagc cgcttttgcg acagcaagct ttttttatgt acaaaacctg
      661 ctccctcttc ctgtgttttc tacagaaagc ggagcaaaag cggtatatag aggagactca
      721 gatacaaacg aagtcgctct tacctttaat atcagctggg gagatcaaaa ggccatgcct
      781 attttagata cattaaaagc aaacggtatt aaagatgcga ccttttttct ttcagcttca
      841 tgggcggagc gccatccgga tgtcgtggaa agaatccgta aagacggtca tcagatcggg
      901 agcatgggct atgcttataa aaactattcg caaatgaaga aaagcgaaat caaaaaagac
      961 ttaacaaaag cacaaaactc ttttcaaaaa ctcggtcttg aggacctcac gcttttaagg
     1021 ccgccgaccg gccagtttaa taaagacgta ctcgatgtcg ctaaacagta cggctatacc
     1081 gtcgttcact acagtattaa ttcggatgac tggacgaacc cgggggttca aaagatcgta
     1141 caaaacgtaa atgaaacggt gagcgctggt gatatcgtgc tctttcacgc ttcagattcg
     1201 gccaaacaaa caaaagaagc cctgcctgag atcgtgcacc acctcagaag caagggactc
     1261 aaaaatgtaa ccgtcagcga tttaatcgca aatacggatg caaaatcatc agaagtaaaa
     1321 tagcaaccgg tctaagcgcg ggcctgaaat tttgggagca ttaaaagttg aaaagcgttg
     1381 caggctaata aaggaagcag cattaaatag agccagtcct cttcattgac ccttaacgcc
     1441 gggaaccact ccatcacagt aaaaacaaac attagaaata atgcggaaac gaacgttttt
     1501 ttagaggact gtttttgctt tgcataagcg gccgcaatgc ttaccgccaa aataaagagc
     1561 ggcagccaaa tatacggaat gatggagcct ccctcttttt caaaaaacag aaaacgcaag
     1621 taaaccaaat caaacgcgac aaatacaatc aaaaacagct gaatcgaatt ccacaaagaa
     1681 tgagatctga agatttccag tgcaaaacgg tgaatcgtta agaaaatcac aaaccccatt
     1741 tgagcaatca cgctaaagat catgccaacc ccgataaacc aaaatagaac agaaagaatc
     1801 tccaatacct cgaaggaaag aaacagctcc ttatatcttc cccactcaat ggcaaaaccg
     1861 acaatacttg tagtcaaagc tccgacaccc aacacggaaa agaaaaatcg gacgagatta
     1921 cggcttttca ttgtagactt cccaacccct aagtaaacgc tgtagcagcg atattttgtt
     1981 atgtataaat ttataaaaga cattcatatt aaaggtaaga cgagttttcg aaaggagctt
     2041 aagcatgttc aagaccacaa tgctatcgat aagctgtttt ctgtttctat ctgtaacagc
     2101 ttgtgctccc acggaccaag cagctgagat ggactatgat caaaccaaaa agatggttgt
     2161 cgatatatta aagacagatg acggaaaaaa agcgattcaa gaaatattaa atgatgacaa
     2221 attaaatgaa acacttgtga tggatgaaaa aaccgtcaaa gaaaccgttg aaaaaacaat
     2281 gacctccaaa aaaggagctg aattttggaa aaaagtcttc gaagatccaa aattcgcaga
     2341 aggctttgcc aaaacacttc aaaatgaaca tgaaaaagtg ctgaaaaaac tgatgaaaga
     2401 tcctgagtac caaaaaatgc tgatgcaggt catgcaggat cctgaaatga ccaaaaaata
     2461 cggtgaactt gtcagaagcc aggaattccg aacccacctg caggaagtca tatctgacac
     2521 tctgtcaagc ccgctctaca gaaagcagtt tgaagaggaa ctgaaaaaag ctgcttctga
     2581 aagcatgaaa gaagaaatga aaggcggcga agaaaaacaa agctaagccg cttttcattc
     2641 actaaaagct tcttccgcgg aggaagcttt ttctgatctt taagctttta cgccaatgct
     2701 ttcgtcgatt tttttggcga tatccaaata aatggcaccg gtcggatgac tttcatcata
     2761 aacggacggc gcaaattcgc tgtcatccca atcgggctgc ttcagcggaa ttttgcccag
     2821 aatcggaaca ccgagttctt ctgcgagctt ctcgcctccg cctttgccga atacgtattc
     2881 tttttcgcct gttttgacgc tttcgtaata agccatattt tcaacgattc ccaagatttc
     2941 atgatcggtc ttcaaagcca tcgcgcccgc tcttgcagcg acaaacgcgg cagtagggtg
     3001 cggcgtcgac acgatcacct ctttgcagct tggaagcatt gagtgaacat caagcgctac
     3061 atcgcctgtt cccggcggca ggtctaagat aatataatcg acatctcccc attcaacctc
     3121 atggaaaaag ttattcagca tttttccaag catagggcct ctccaaatga caggggcatt
     3181 gtcttcaaca aaaaatccca tcgaaattac tttgactccg aatctttcaa ccggcacgac
     3241 cttttctcct tcaatcgtcg gccgtacagt gattcccatc atatccggaa cgctgaatcc
     3301 gtaaatatcg gcgtcgatta atccgacttt ctttccgatt cgagccaaag acacagccaa
     3361 attgacggac accgtcgact tgccgacgcc gcctttaccg cttgccaccg ctaaaaacac
     3421 aggctgtttt tcactattca gcagagattg atcctgccct tgggcagact cttgattatt
     3481 catcacgact tcttcaggca gctcctcaaa acgcaggccg accgtctctg caccggcttc
     3541 ttttaaccgt atgacgattt cctgctgaag ctgcatttgt tcggcagatc ccgtttttgc
     3601 gagcgccacc tttacgctga cgtgccgttt ttcgggtttt attttaattt ccttgacggc
     3661 atccagctct ctgagcggct tgtgaagaaa tggctcgtcc aaatcgccga ctattttttt
     3721 tacatcgtct tctcgcaaca ttgatctcac cctttgttgt attcgtttac aaaataagta
     3781 tagcatatct ttccttatag tgtctttgac acaaaaagaa accctcttat tcaggagggt
     3841 ctctgtcttc tgtaaagtag cgcaatacac ctttatatac ggatgccgcg attttgtcct
     3901 gatatttggg cttggccagc tgttttgctt ctttcggatt tgacaaaaac ccgatctcga
     3961 cgagggcccc cggctttttc acattttgca tcaaataaat gccgtgtatc cgctttgcct
     4021 tccgcgtcgt gttttcaaga ttatgtctta attcatcctg aataaacttg gcggcccgtt
     4081 cgttttcttc atattgcccg taaaagaagc tttgcgcacc gctccatcgg gcggaaggaa
     4141 tcgcattcaa atggatgctg aggtaaaggt cggcttcaga attgttgatc acgtcgaccc
     4201 ttttccgcaa gtcttccgct ttccttctgc tgagcccctt cgtttcttca ggagcgagat
     4261 catgatcgtc ctcccgcgtc agcaacacca aggcgccctg ttcctggaga tagtccctga
     4321 ttctaaggga tacttcaagc gccacatctt tttcaaggag ttcaccgctt gatgctcctc
     4381 catccgcgcc cccgtgtcca ggatcaatat aaatgatctt gccgctcaac ggaagattcc
     4441 atgaccgcca agaatcatca ttgtgaaatt gatattgaaa taaacataat aaaacgacaa
     4501 agccgagtaa aaacccgagc cattttattt ttttcttcat ccctttccct cccgctcgtc
     4561 cttactacaa catatgggac aaggaaagga aatatgattc agcttggccg cacttttaca
     4621 taaattatct gagccgaagc ttaaagcgtc tttcccgctc gctgaagcct tccttccacc
     4681 agctttggat gaagtattcg caagcataat agagtggttc atgagccgct tgaatattaa
     4741 aagcctcaga ccagctcacc gcatattcat aaagctcgtg cagaagctgt ttttcttctt
     4801 tttctgagcg gaccatcgct cgttgaacgg gctctccgtg atagccgaac tttccgtact
     4861 cggctcccag caaataggcc tcaatggcaa aatcgatgca gccgtcatac aaaatatccg
     4921 tgtgcttaga aaaaaaatga aaaagaggag caaagcattc ctccgcagaa ttcagcattt
     4981 tttccaaaga cagttcgcgc agaagctttt tttccaaatt gatctgcttc ttttgttttt
     5041 cattgttaaa agatacgacc gtccccatag aaccgcctcc tttttacctt gtattgtgca
     5101 gtcaggagcc ggaaatcatg cttttctaag gaagggaaac ggaggaagaa gccgaaaata
     5161 ttaggagagg ttagtttcag ctcatttatg cgcgccatcc ataaagtgtt ctgcaaagga
     5221 aaatcagttt ttagtctttt cttattttca atacttgttt aatcatctgt ccagcagcat
     5281 aaataaaggc gcaatgatcg attggctaaa tcgattcatc gtgccttgta tcaagtaaaa
     5341 gttttacttt tatatcaccg cggtgagaag ttctttgagc tcacggtatt tgttacggct
     5401 cacattgata atctttttgc agtttttaat ttttagatta tacgacttca tgtaggtgtc
     5461 ttggatgatt tcctcaatct tatccaacgg aacgaggaaa gactgatggg ttctaaaaaa
     5521 gttgctccct ttaagcattt cctcaagggt catcaaacat tgacttgact taatgatctt
     5581 tccattttca agatttatgc aggattttct ccccaccttt tcaatataca aaatgctgtc
     5641 tacatctacg agatgaattt tgccgctaga actgatgcct atctttttat tgtttctttt
     5701 tgaaaaagcc ttatgatttc gaagaagctc tacagctgat ttgagtctta aaatgttaat
     5761 cggtttgact aaaaaatcaa taggataaaa cttatatcca tccagagcgt attctgtgta
     5821 ggaactcatg aacatgatgc tgatactggg ataatactct ttcagatatt cagctaaatc
     5881 gaaaccgctt gactgcttca gattgatatc gataatgacc agatcgactt cattcacaga
     5941 ctccaggtgg gaaatcaact cgcttatttc tcttgtgatt aattcaaatc tagcatgact
     6001 gatgctgtcc gaaacctctt tgaaaaaatc aagaatatct tgatcatcat caatcacgca
     6061 tattcttacc gtcaatgatc gtcactcttt aaatcctcag gcaattccgg ttcataagca
     6121 aaccagaaac agctgcttag tgaagtaatt gaattgaaaa acaaagcgga tacaccaatc
     6181 aaataagtaa taaatttcac catttcccta gtcccctttt attttttatt aaacctctta
     6241 tcaaaagata agatgatttt atgccatgag tcagtcaagg taatgctttg catgatcatt
     6301 gcgatccaaa tgccgtattg aagctggctg tcaaccaaaa ggctgaccag catgagaccc
     6361 agaaaaacgc aaatcgacct atatttaatc tctgttctct gttgaggact gaatacctgc
     6421 atctttttat gcagtttcgg tgattttttt aagaaaatga aaaatgacaa gacaatcagg
     6481 ccaatcagca tccatttcat cccccgggag aagtgaaaag caaattctat ggatatgtac
     6541 gtgatcacca taatttgaaa cgtgctgaaa aataaacaat aataataacc tttaaagtgg
     6601 cttccccctg aaaacattct caaaaatccg cccgccgaca agatgaccat ggcttgtatc
     6661 acgcagtcaa aataacaagc tataataaat accagcagta tttgattgat ggcggcaagc
     6721 atccactcaa gcccgtatcg tatgctatct tgcctactac gaaaatcagg gttgtaataa
     6781 atgatctgtt ccgaaatttt ttttgacaag taattgggtg tgaacttaac catcgcctaa
     6841 ctccttcgga atcctgactt tgaagacgat catcctatcg atgatctccg gaaagatgaa
     6901 tccttgatgc ttctcaacga ctgatttaac gatatggagg ccatatcccc ttcccttctt
     6961 gcctttcgta gaaaatcctt cttcaaaaat ccgatctacc acctcagcga accgctctac
     7021 gtctccaaag ttgcctacat ctattctgta gtaaccttct ccggaatcaa tctggacata
     7081 tactgtccgt tctggaatat caccgagttc ttttacggct tccactgcat tcatgatcag
     7141 gtttccaaat attttatttg tttcaaaaag cttgcatgga aaatccctca gactatcgct
     7201 gattttatag tgaatacgaa tatcttcctt taaggcttta tccttatacg aaaggagcag
     7261 ggcgctgagc gcaatggaat ggataggaag tatgtcgctg attaaagcgg agtccttcat
     7321 cacgtcactt agataatgtt tcgtttcttc atattgccct ttattaagca tttgttgaat
     7381 tgcgataaga tgatgcccct gatcatggtt atgttttttt atgaagtgaa tgtatttgcc
     7441 aacctcctca tattgttcct ctaaagaatt ctcagcgtta cggaggtttt tgtagaaaat
     7501 gcgcctcatg ataatcaagg tgaaaaaagt taatgaaaca agggcaatgc tccaaaaaag
     7561 attaataaag ccctctactt tttggttctt atagatgatg aaatagtata gaagcagcaa
     7621 agaaaatgac agtatcaaaa tcatgtacaa ttttatgtcc aagtctttca cctgtttctt
     7681 cggtgaaatt aaaaccactc tcttttttcg aattaggaaa agcatgaata aaaggataca
     7741 aaaatggggc aatgccgtac caaggcttcc ctcttttaca ttgagaactg gctcggcaac
     7801 tcttaacatt gcgaagccaa tcacttcgga tacgagtaaa caaacagcac ccaataaaac
     7861 gccgattatc gataacagaa ttctgaggtt caaaaaaagc gaaaccggta aactgatcgc
     7921 caaaaccata atggaaaggt acagcagagg aggaaaagaa cttttcacca gatacaatac
     7981 aatgcttccg taaaggctga ttaagagcag gctgaaaaat ttgtttttat agctgacatt
     8041 caataacgaa ataccaatcg ttataatcaa gaatgtttca agcatacctc caattaattg
     8101 ggttggcaga tccattacta acactcctaa aatatacata ttaggtattt catctcaatt
     8161 atacaaagaa ggaaagttta tgtatagata ttttcgaata tttaacttat tggacacaat
     8221 aattttgaaa tagggcattt tgcacaagaa ataatccaaa atagcccaaa aataatccaa
     8281 caattctaat tattgttata ataatgctga gctcccaaaa ttaattaaga ggtgaaggaa
     8341 aatgtcaaag atcgaagcat ggaaaaatcc tgttgcacgt atgaacagcc aaattgtaag
     8401 tcctgccggt gacttaatgg acgagttgtc agacagtgaa atggaaatgc ttgcaggcgg
     8461 ctgcgagtgg tataacatca gctgtcaatt aggtaacaaa ggtcaatggt gcactcttac
     8521 aaaagaatgt caacggagct gcaaatgaaa cccagccgat attaacgact gtctacaaaa
     8581 ataatgttaa taaagagatg taggaaaact tcaaatttgg aagcatggaa aaatcctatt
     8641 acacaactgc caagtgacca accctgcggg tgatttaatg gacaagctgt cagacagtga
     8701 aatggaaatg cttgcaggcg gctgtgcttg gtgcaacatc agctgtcaat taggtaataa
     8761 aggttcctgg tgtactcttc agtacaagat attagttgaa tctggccggc attttgccgg
     8821 ccgtgtgcat ctcattcaga aaaaggttag gagtgaaaca atggacagca tgttgaaggg
     8881 aacggattca gagcggttag agcagatcaa attttggagc cgtttcttct acaataatga
     8941 agagtatatg aaaagaagcc taaatgaaat atctggaata aacattgatc atatattagc
     9001 cttaaagttt ggcggcaaaa agagtgctgt agaaaatgtt catccctggt ttgatgattg
     9061 ggatttaatc cttaagggag cgcttgatcc tctgccggca cgccagacgg aacaaaataa
     9121 aaagttcggt acattcatcg atcatttcct gaaactagct ttctccaaac ttaaaacttt
     9181 atacatacat aaccattcat tcgatttttc agaaaacgag ttatattcag acttgcttga
     9241 acaaatgaat gacgacatct attctatctg ccacaagacc ctcgtgcttg agctgaatgt
     9301 ataccgagag cagggactcc tgaaaggcag cacccccgaa gagcggtatg actatttcga
     9361 acatgaaatt ttgacagata aaaagttcct atcctcattc ggaagcgagt atcagagcct
     9421 catctccctt ttgatccaca aagtcaatag ctcagttagc tttattaggg atattgttga
     9481 gcatctagaa aatgactggc ccgtgctgat taaaaccttc ccgaaaatag gaagattaag
     9541 gaagattcac cttggtaaag gggacacaca cgacaatgga aaaagtgttt caattttgga
     9601 attcgaaggc ggccaatcgc tcgtctataa accaagaccc ttggacgcag accaacaata
     9661 tcagaagttg ctatcttggc taaatgctca ggagaacaat attccgaatt tctacaaaat
     9721 gaaggtggtc aatgcagatg atcatggttg gacggaattt attcaatata aagcctgcca
     9781 atcagccgaa gaagtcaaag atttttataa acgtatgggc gctcaacttg ctgtactgta
     9841 tgtgttgaac gcaactgatt ttcactatgg aaatatcatt gcaatgggtg gtcacccggt
     9901 gttcgtcgat atggaatcat tgtttcatca gaatatttac gatgacagtt acagcaaaga
     9961 agctcttgga caagccgata aaatgctctc gaaatcgatt atggcttccg gcatgctacc
    10021 taatttgctt tatcagcgga aggaccggaa taaatcaggt gttgatttaa gtggattggg
    10081 agggaaagga aatcagcgcc tcccgtttga agtggcccaa attgtcgata agggtactga
    10141 ccaggcatat ttgaaaaagg ggatagcctt tttggaagcc ggcctcaatc tgccaagcta
    10201 taatgggaag ttcgtgaatc ttcacgatta tctatctgaa attgtcgagg gctttacggc
    10261 cgtctaccga tttatggctg caaacaaagt agagcttacc agccagttgc aaggattcaa
    10321 gcaagtcaga gtcaggacga ttttaagacc aacagcggtc tatggagaat tcctgcgtag
    10381 tctagtccat cctgatttgc ttcgagatcc agttgatcag gaagtttttt tacacaggct
    10441 gtggctaaag tgcctccagg ttccaaaaat ggagagtatt atcattgatg aaatggaaga
    10501 tttacgccgc catgatgtcc ctttattcac aaccagaccg ggcgagcggc atttatggag
    10561 ctcaaacgga agagtcatca gagacttctt tctttcccct gcgtttgacc ttgtcttgga
    10621 aaagatacga agtcttgacg aaaaggactt atacgggcaa ctacaggttt tgcatatggt
    10681 catgctcgcc tcaagtgcag atcattatgc ggatgttgag aaaattgatc cattctggaa
    10741 taagacagct ccggctaaag aagatttcct agaacaggca gtcgatatag gaaattactt
    10801 actgaagaca aaaatacaag gggtgaacag gaacaaaaag gatcttacct ggatcagtac
    10861 cgtgctggaa ggaaacaatg aagtgatatg gaaaatttct cccgtaggac tcgatcttta
    10921 taacggcaac agcggaatag ccctctttct agcttacctc tcgtatttta caggtgaaca
    10981 acgatttaaa gaggcggcgg aacaagcaat tgttccgatt ctaaatgata tgaaaaaatt
    11041 cagcgaaaat ccaacttgga gcctcggggc atacagcggt gtaggcggaa acctgtttac
    11101 aaccatccta cttgcagaac tctggaatga ttcatctctt caccaacagg tggaaaaagc
    11161 cttgccagga tatatcgcga tgatcaacga ggatacaatc tttgattata taggtggtgc
    11221 tacgggagca cttgacatcc tgctgtgtat tttccatcga acaggaagca tccaagcggt
    11281 taagggagct atttcatgcg gaaaacatct aatgaaacac ggtcgtgtaa tgaaaagcgg
    11341 cggaatgggc tggccttctg tcttggacgg ctcagttctg acaggctatt cgcatggtac
    11401 gggaggtacc gctgctgctc tttcctctct caattactgg actgaaaaca aagcaatcct
    11461 tccgtatata tcgaaagcct tggaatatga gcggacattt tatgatgaaa aggagaaaaa
    11521 ctggcgaacg ccaggaaggg atacatcctc atacgcctgg tgtcatggag ctccgggaat
    11581 actattgtca aggctccgcc tgaaggaaaa tggctggacg gatcctttgc tcgacaggga
    11641 aattgaagtt gcgcttgaaa cgactttgca caaaggattt ggtaataacc gctcttactg
    11701 ccacggtgac tttggacaat tagaaattct cctctatgcc aaacaagtac ttcaggatcg
    11761 tgaactggac gtttatatcg aatctgtcag atcgcaattg ttggagatcg ttaaacagaa
    11821 aatgtggaat tatggtatat caaggggaac ggaagctaaa gggttaatga ccgggctggc
    11881 tggcatcgga atggggttat tgaagcaata tgacagtgag gcggtaccga acatattgaa
    11941 tcttgaaaac aaactacttg aaaggaggtg aaacgaatgt cacatcgtga aatggctgca
    12001 atttaccgtg atgccaacaa acgtgccaat cttgagtttt ctaaccctgt cggcgaggtc
    12061 aacgaagaag aattaaagaa ccttgcaggt gctgcggatg ttacaccgca cactactcct
    12121 tcttcattgc catgtggaac attggttaca gctgtttggt gtccgtctaa cgcatgtaca
    12181 tctgattgct aatttggcca atgctagtat gagagggatt tagaatggga gctcagatcc
    12241 ttcttcttac ataacgtttg gccggaaaat gaaaaacaag gggcggttgg tcatgtttta
    12301 tcgaggccaa ccgtttcgtt atctattata tccaactttt cttaaatgta tgcataaaag
    12361 aaaggggaga ttaacatgac tgttgcaaaa atgaaggata tgttcagccg ttctgcttat
    12421 ctgaatgaac gaaaaattac cggcacaaaa acgccagctg ttaatataaa agagttcaat
    12481 aagtggaaaa gggctatacc cgaaggaatg ctcgagaagc ggctcaaaat ggaccgcttg
    12541 actatagaac agctgatgca gtacatagaa gagaaggata atccagttgt ggagaaagaa
    12601 ttgccgtgga ctacggtatt tgaaaaagtg atgcatacat ataaatcaac tccattggat
    12661 tacaccagct ttcaagcatt ggttgatcct ttcatccagt atgcgaaaaa gcggcttgct
    12721 gatgcactca ggcatattaa caccagcctg gtaaaccttg aaaccataat caagtcgatt
    12781 gctaatacac tttatgaacg gcttcattca atgctgatga aatgtgtgat tctcgaagtc
    12841 aacatcgcta gaaaggtcgg gatgctcgaa ggagaaacgg gtgaagaacg atttgagcac
    12901 tttatgcgcc aactcaatga ggatcatgaa ctcaggatgg aattcttcgg aaactatcca
    12961 gtcctttcgc ggttgatgac tgagagcatg caaaatactc tggacgtcac cgtggaacta
    13021 atccaacgtt ttgtgaaaga tcacgagagc atcaaatatc aatttgggaa ccgtctccat
    13081 cgattagaga gactgaaaat gggcctcggt gatacacatc aaaacggcag aactgttgct
    13141 ctactggaat ttgaaaccgg caacaagcta gtttataaac cacgacagat tttgatcgat
    13201 aaaattttcg aagccttgct gtcttggctg aacgggaaag gtttgcagta tcctctccaa
    13261 tcagccaaaa gtttggattg ccgaacctac ggctggcagg agtttgtccc gtacgaaaag
    13321 tgcacacatg aagatgaggt gagtcgcttt tattataggc aaggagctta tactgcgctg
    13381 ttctacatct tgggctcctc cgattttcat gcagaaaata ttatcgcgca cggggaatac
    13441 ccagttccga tagatttaga gacgcttttc agccgaaatc tggaaatgat gaaacagctc
    13501 agagtccaga gccgactggc acttgagcta aacgattcgg tctactcaac tttgatgctt
    13561 ccactccctt cttttgagca ttcaattatt gactttgact tgagcgccct aggcgcaggt
    13621 caaaaccagg tatcaaaaaa aataaagagc ctccatcttg aaggcgaggg aaccgatgaa
    13681 attaagatga cccgtgttcc cgcaaagtcg ggtgagtaca aaaacaaacc gatgtttaaa
    13741 gggaaaacaa tgtccgcctt cgattattcg gctgaattgg aaacaggttt ttcagacatg
    13801 tacaaactgt ttcttcgcca taaggaagaa ttcatgagtg ttgatggccc tttgcagcct
    13861 tatggtaaag cccatgtccg ccaggtattc aggccaacac acgtgtacat ggaattcctc
    13921 cataacagcc tgcatcccga ttatgtacag aacgggcttg accgagtgca aatgttcgat
    13981 attctgtggc aagtgaccaa ccaaagctca aaattcgagg agctagtcaa gcatgaaaca
    14041 aaggatctgc taagacatga cgttccgtat ttctatttta cactaaacag ccgtgatctc
    14101 tataacagca atggacacct tatctcctct ttcttttctg aaacagggtt tgaatctatt
    14161 ttcaaaagga tcaacaaact tagcaaaagc gacttagaaa aacaaacaca atatttaagg
    14221 tggtctctcg catccatgct gggcgacgta tggaaatttc atcagaccgt cccaacccta
    14281 cctaaaagaa aagggaacct ttctccttcc tctatcatta aggaagcatt ggagctaggc
    14341 agacaattaa aagacagggc tattatcgag gataaccttg aagtgaactg gcttggatta
    14401 aatttaaata aggaaacagg cgttaacgtg tcggtcaaga gctctgatct atatgatgga
    14461 ttacttggct atgctctctt tttggcttat ttagcgaggg aaacaaacaa ttgtcaatac
    14521 gaaaaactaa gccgtggtgc gatcaaaaca gttattcgaa aagccggcga caaaccgctc
    14581 aacccttccg tttcggcttt cagtggagaa ggcgcatttt tgtatggact ggttcacctt
    14641 ggactactat ggaatgaccg cgaactgatc cggcgggcaa aggaaaggtt gccttcttta
    14701 catgatatca tccgtgatga aaaaaaccct gatttctcag gaggtctggc cggttttatc
    14761 gtgatgtcgc ttaatatcta tcaagaaacg ggagacaaag actatttgga tatggctcaa
    14821 tttgcaggag atagactcat gcagctgctg actgaaatcg atgaggggac cggccttgct
    14881 catggagcat cgggatacgc ctgggcactc ggctcacttg gaaaagtaac agggaagaaa
    14941 atctataaag ataaaactga aaaattactt ttatatgaaa atacatttta cgatccagcc
    15001 acaggcaatt gggactcggc tgcagcttcc gaaaatcaga aacgaaaaag agtttactgg
    15061 tgtcacggag cgccgggcat tgccctatcc cgactgatgc tgaaaaacac atcaaattta
    15121 gaacttatcg caaaggacct cgacatatct ttgaaaacgg tcatatgcga aggggtaata
    15181 gaaagccact gtctttgcca cggaactatg ggaaacgcgg acatcctcct aacagcctcc
    15241 caagagctga atgacgtaaa actggaaaag aaagcaaggg atttagttga tattgttctt
    15301 tcccagaaaa agacgtacgg ttggaggttt ggcttagatc ctagagcgga gatggatggc
    15361 ttcatgcttg gccggacggg gattgggtat agcctgttga ggttcaaaaa ccccgaaata
    15421 ccatcagttc tggctttgga gctgccaaag ggaggagccg tatgttaaag aagaaaaaat
    15481 tatttccaac tcgcaggcgt gttcctttca ttgaacagat gcagcagacc gaatgcgcac
    15541 tttgttgcat cgcaatgatt tcgtcctatt acaaaaatga cttatccatg tacgaggttc
    15601 gggagcgaat gggaaacggc cgtgatggaa cgactttgtt ccatcttaaa aagttggcgg
    15661 agcagctgaa tttcgacacg aaatcgtata aagctgatag ccggcaactg gggactctca
    15721 tactgccagc aatcctgtac tgggaaaaca atcatttcgt tattctcgag aaggttgcac
    15781 aacaagctta tacaatcgtt gatccaggtt ctggaaggag gaagctgaaa gagaaagaat
    15841 tcacggagaa atattcggga tacgtactta ctttatatcc caacaaaaat tttgaacgcc
    15901 ggagcagaaa aaacgtctgg gcatccttct cttatttagt gacgaatagg ccaaagattt
    15961 tcattagtat cctgtttctc acattcttgc tacagatgtt cacagtagcg atgccaatct
    16021 ttatccaatt tgtcattgac aagattattg tccccgacta tcgggatcta ctgaatatat
    16081 tcttagccgg aattggtggg ctgatcctat tcaataccct atttacgttt ttacggggga
    16141 gaattctgat cactcttcat aatgcgcttg attatgagat ccaaactaga tttttcagtc
    16201 accttctcag gctgccgtac cagttcttcc ttctgcgttc cttcggagat ttgcttttta
    16261 gggcgaacag catgaaggtg atccgcgacc agctggccaa ccaggtagta aaaggtctgc
    16321 tggattccgc tgttttgctg gtcatcctat tgtatatgtt cttgcaatcg cctctaatgg
    16381 tttttatagt cgctttgata gcatctacca atgtaatact aatcgccgtg agccaaagat
    16441 acctcgcaga gacgaatcag atggagatta aagagcattc cgaagtgcaa ggagcgcaga
    16501 cagaaatgct ctatggaata tttggagtaa agacgtccgg tgtggaaagc aagatttaca
    16561 atagatggct tcagagattc aggaatcttc ttagcgctta taggaagaaa gaaattgtac
    16621 tgaaccgcgt aaacaccgca agcaatacaa tgcagcttat ggctcccctg atcctcttat
    16681 gggttggagc acaccaagtg tttgcaggaa gtatcacgct tggggtattg gtagcatttc
    16741 atgccatttc aaaccaattt ttcatgttga gcggcaatat cgttcaaacg atcaattctt
    16801 ttatcttgac aacatcctac ctaaaacgag ttgaagatgt cctcgatgca cctggagaaa
    16861 tggagggaga caagatgaaa aaaacacttg aaggcaatat tctgttaaag aatgtcactt
    16921 tctcctactc taaatacagc gaaaatgtga ttcataatgt tacactcgat atcaagaaag
    16981 gacaaaaagt tgctcttatt ggacagtcag gatcaggaaa aacgacactc gccaacatga
    17041 taatcgggct attcgcaccg tcttcgggag acatctatta cgacggcgtt agcatgaaag
    17101 agcttgatct gggccacctg cgtcggcaaa ttggtaccgt acctcaaaat gtcatgctgt
    17161 ttaatagaag catttatgat aatataattc tccataatcc agaggcgtct cccgaagaag
    17221 taatcgaagc cgcaaaggct gcccaaatcc atgaagaaat tatgaagatg ccaatgcagt
    17281 atcatacaat ggtatctgag atgggcatga atatttctgg cgggcaaagg cagcgaatcg
    17341 ccctcgcaaa ggcgcttctt ggaaaaccgt cgattctcgt ccttgatgag gcaaccagct
    17401 cacttgatca tttaaatgaa tcaaagattg acgagtatct ctctgatatt aactgcacaa
    17461 gaattgtgat tgcccataga cttacgacag taatgaattg tgacatgatt gtcgttgtcg
    17521 acaacggaag aatcatcgaa tcgggcacac accatgagtt gctgaaaaag tccagtttct
    17581 acagtgaatt ctataaagaa atgatttcat aacacgctct tggatcgtca agaagcgtgt
    17641 ctttttctaa aattcgtaaa gcacacttta caataagtga agtttacttt acaatttaat
    17701 tgaaataact aattatggag gatgattacc atgaatatcg aacagattgc ggtatacgga
    17761 aatagtattg gaggagtggt gatcctcgcc tgcctggcaa ttatctggat agtatcgagg
    17821 cgtatgggca gggatgaacg gtcagaagca attttcctaa gagtctactc atctatgttt
    17881 tatgtgcttg cagcgcttat cgcactgagt attttcttcg gattcggcca tgacatcagt
    17941 ggactaatgt atcaaaaaat aacgtcatta atgtttgcac taagcgtaat tttcggtact
    18001 atctatctgt tcattttgaa aagaaagtac tgattccaca tttgacgaat aaaacaagga
    18061 aaaatgcgat caaggggatg aaaaaatgga tgaacatcaa tatattctgg aaacgagaca
    18121 attaaccaaa acataccgta aaacagatgt tgtgaaaaac gtgaatttgt gcattcaaga
    18181 gggagaaatt tatggcttcc tcggtccaaa cggtgcagga aaaacgacga cgattcgcat
    18241 gctgctcgga ctcatcaacc cgacaaaagg cgaaacgaga atcttcggga aggacttgaa
    18301 aagcaatcgg cttgacattc tgcgaaacgt cggttcactt gtggaatcgc cgtcatatta
    18361 tcctcatctc acaggcgagg agaatctgga ggcaatccgg aagatactga atgttccgaa
    18421 gtctaatatt gacgatgtgc ttgagatggt cagattgacg aaaatggcgg acaagaaagc
    18481 gggagaatat tcgctcggca tgaagcagcg cttaggcata gctgcagcgc tgctcggata
    18541 tccgaaactc gtcattctcg atgaaccaac aaacggattg gatccggcgg gaatccttga
    18601 aatacgcgag ctcatcctca gactgccgtc cgattacggc attaccgtca tgatctcctc
    18661 gcatttgctt tctgaaattg aacaagtagc cacccaggta ggaatcatcg ccaacggaga
    18721 aatgctcttt caagacgcga tcggagagct ccgttcgaag gccgatacaa agattgtatt
    18781 ttcgacaagt gacacggacg gggcgttaga cattttctcg cgtgagggcg tagaggcggt
    18841 taaaacacag cgcggcctga tgattgagga caggactgat atggaaattt cccggctcgc
    18901 cagaaaactc tttgaaaatg agattgacat cttccgaatt tacgacgaat cgaaatcact
    18961 tgaagatatc ttcctcgaca tgactaaagg gggagaaaca ctgtgatctc tgaattgttg
    19021 aaatctgaaa ttctgaagat cagaaaactg acatgggtaa tcgtcatttt cggcccactc
    19081 ggagtcgtcg cgatgcaagg ggccaattat gcgctccgct ttgattacct catgtcgcgg
    19141 aacccggata aatggctgtt cctgcttgaa aacatccatg cctactggcc gccttccctc
    19201 cttctcggaa caacgatgat caactcgctg ctcgcgggaa tggaacatca tgcaaatatg
    19261 tggaagaaac tcttttccct ccccgttaaa caatggaaag tgtaccagtc caagattatc
    19321 atcattatca ccatgatgct gatctcgaca gctatacttc ctgcgggcac atatgtgctc
    19381 ggcagactgc ttggattttc ggagacattt ccgctcgggg atgcgttgat gatgagcttt
    19441 tatacattat ttgcagcact acctttcgtt tttttacagt tttggctctc ggtgaaatat
    19501 tccaatcaag gaatcgcttt gacaatcggc atcgcaagtg cagtgtttat catgtatgct
    19561 cacggactgc ctgagtggat gccatggaaa tggccattgt taatagatgg tatagggcaa
    19621 agcaccctct cagtcataaa gggattggcc gtgggactgc tcatctattt atttgccttg
    19681 ttatccctat cacgaaagga tgtcgcatag tatgttctat caactattga actccgagtg
    19741 gctgaaacta aaaaattcaa aaatctggtt tatcgtgctc gccagtccag ccctttccgc
    19801 tgtcatcggt tttttcccgc tcttcagcat tggctcgagc aaatggcttg cactgagcac
    19861 acaaatgatc cttacgcaca gtgcgctgtt tttgccattg ttgacaggtg tacttgccgc
    19921 tctactgtgc agtaacgagc atgcccacgg cggatggaag cagctgttga ccctgccggt
    19981 gagcagggtt caagtgtacg ctgccaaata tgtcatcatc atgatcttgc tgctattcac
    20041 gcagctgttt ttcctgatcg gcatctggtt tgtgggaagc gttcaaggat tcggctctcc
    20101 gttcccctgg tacagcctgg tcatgagctg ccttatggga tggctgtcgt gccttccgct
    20161 tgccgccctt cagttttggc ttgcgaccta ttttaaaagc tttgccggtc caagcaccgt
    20221 caatgtaatg ctgacattgc cggctatcct cattgccaac tcggagctgt tgggacctct
    20281 ttatccttgg tctcatccaa tgctcagcat gacacaggct ttttcagctg caatgggcgg
    20341 agatgctggc tttttggcga atgaatcagc tttttatccg acgctgattg tcagcttcgt
    20401 tgcattcatc ggcggcggtg ctttatattt tcacaaaaag gaatggacat agaaattgat
    20461 caatggggga caggtatgaa tgcagaaaac aaacagaaaa aaaaactgac gaaccggctt
    20521 ccggaatggc gggcgcgcac caagatgacc cagcagcaat tagcggaacg ggcgggtgtg
    20581 agcaggcaaa caatcatctc aattgaaaaa atgaaataca ccccttccct cacgctcgca
    20641 tttgaaattg cacatgcgtt cggctgttcg atcgatgatg tatttgaata caataaagaa
    20701 gatgtgtaac gaaatagaaa ggagcgacga ttcttgatca tcgaaacgaa aggcgtgacg
    20761 aaaacataca accgcatcga tgtcgtgaaa gatgccggtt tgctggttcc ggaaggagaa
    20821 gtatacggat tcctcggacc taatggctca ggaaaaacaa cgatgatgcg gatgttgatg
    20881 ggcttgatcc gccccgattc cggtgagatt cttatgtttg gaaatagaat gcctgataac
    20941 cggatttcaa ttctagccaa gacgggcgcc ctgattgaaa agccctccta ctatgaacat
    21001 ctggacggac gcgataattt acgtatactg gccaccctgc gcggaatctc agacaacagg
    21061 gctatcgact gggcgcttga aagagtcggt ctgcaccgcg tcggatctaa aaaagtaaag
    21121 tcatattcac tcggcatgaa gcagcggcta ggcattgcca gcgcgattct tcacaacccc
    21181 aggctcctgc tgctcgatga gccgacaaac ggattggatc ctgagggaat ccatgaaata
    21241 cgggagctaa tccgcgaact gccgaaaaaa gaaggtgcca ccgttcttgt atcgagccat
    21301 cttcttggag aggtcgagca aatggcaaat cggataggtg tcatttacca tggaaacctt
    21361 ctgtttcaag gagaaatggc gacattgctc tccgatcaaa aatctggtta catcatccgc
    21421 tcaactgaaa gcggaaaaat catcgatatt ctgcacgaac atggcttaga gacccgcgtt
    21481 gaccgggctg agcaagtgca agtttctgga gcagtaaaag acaaaataga aggcattttg
    21541 attgaaaatg aaataaccga ttttcatata aacgaatctc cagggacgct ggaagaagcc
    21601 tatctacagc taatccgttc ctccgaggtg tctgtatgaa aagcgttttt gcagccgagt
    21661 ggcggaaaca aaggcccgca gccctcctgc tgccattatg ttccggaccg ctcctgattt
    21721 ttgcggcctg ttggacaatg atgctctatt tgacaaaaaa cgggcgaacc gcggaacagg
    21781 ccttccgcgt cctttatgag ctttgcacct tgacttggag ctatctcatc atctttgtgg
    21841 tgatgatgtt caccttgtta gtgagcgggg ttgagcacaa atcgggaatg tggcccgttc
    21901 tcctttccac tccgcatgca aagtggaagc atttttttgt aaaagttatt ctagccacct
    21961 tacttgtcca gctattcggt ttgatcctgt ggctgctgat gggcggacta ggcttcatat
    22021 tcggagggac attccctgaa ccattgctct acacggcatt tctgtttgca cttccttttg
    22081 ttgtctttca gacgtctgcg acagtcgtgg ttgaaaatcc gtatatttcc gtcagcatcg
    22141 ggatggcggt tttcctcttt catgctgtgc tgccttattg gtggctccca tggggtccgc
    22201 ttgctgaact gttgcgggcc ggaacacagg caaacagctt attaccagtt ctcatgctgg
    22261 tgtcgacact ggggtacggt atgttatctt tactgatttt ttaccaaaaa accttttctt
    22321 ccggaggtga gtgaaatggc aagctttcag caggcgtttt cggcagaatg gatcaaaatt
    22381 agaaaaatga aaatctggct gatgatcatt atcctagttg tcctgcctgt catctacgga
    22441 tggattattc atacaaaaat catgattgga aagtacgttt acaatgaggc gaattcttgg
    22501 cagattctta tgatgatgac ccagatgttt tatggtacgg tcttctttcc gattatcatc
    22561 tccctgatta cgggcacaat gtccaaatat gaaaaacaag caaacaattg ggagcatttg
    22621 ctgatgattc ctgcaaaggg aacagtgttc tttttaagca agatggcttg gaccgtaatc
    22681 atcattctgt ccgcacaatt gctgatgttc ggtttgcaga ttgtccttgg ctatgcttct
    22741 ggatatacgg accaaatccc aataggcact tacttatcgg ccgtaatcct tggaacggcc
    22801 ggggcaacca gtctcggaac gctcctgttc tatttttatc tacgaatgaa atccgctcgg
    22861 acggccctga tgatcagcat attcttaagt tttccctcct tcttagcctt ttcgaacaat
    22921 acggactcgt tgataccagt cctttatcca tgggcactgc cgctctatgg gatgacaaat
    22981 gtatatgccg gcaccgacag gctggcagta ttttttatcg tctgcgtcgc gatgaccgcg
    23041 ctcttctcgc tgctcagcat taaaaagttg aataacagaa ccttttattc atgatagcct
    23101 gatactaaaa gccaataaaa actactaact tctcggcgaa ttcaacatgt atggtaggct
    23161 gggaggaaaa atcatgaaca taaaacgaat tcacatatta ttattgtgcc tgctcgtcgt
    23221 gatcatcttt gccctgcccg ggcaggcttc cgctaatgac agtcaacttg atagatatac
    23281 gatttaccta gagagcccag cccatcacga tgattgggtg aagacactta atgaacgaaa
    23341 cataaaactt gtatactcag tcgaagaaat cgggctttat cagatagaag gcagacaaaa
    23401 agaggttcaa gaattggcgg ctgaaataaa ctatataaac agccataacc aatctgtagc
    23461 catgcagcct gcctcactgc ataacactgc tccggcggag gcgacgatat ttgggggcac
    23521 ccctactcta tgggacgact tccaatggga tatgagaaaa gcgactaata atggacagac
    23581 ttatcaaatc accgaaggaa gcaaaaacac aatcgtgggt atcattgatt ccggaattga
    23641 catgaaccat ccagatttga aagaaaacat cctctccgtc cgaaactttg tgcctaaagg
    23701 gggactgaga ggacaggaac catatgaaaa gggtgacata aacgacagca cagattacct
    23761 gggacacgga acatttgtag ccggtcaaat tgcggcaaat ggattgatga aagggatcgc
    23821 tccagaaaca ggaatcagat cttacagagt attcggcggg aaaagcgctg acacagtctg
    23881 gattattgat gcgatcatcc aagcggcgat cgatgatgtc gatattatca acgtcagctt
    23941 cggtacattt cttgtaaaac aaaatcggaa gaacaaacaa atgcctgata cgaatgatct
    24001 ggctgaaatt aaagctttta aaaaagcagt ctcatttgcc cataaaaagg gcagtgccgt
    24061 tgtagcctca attggaaatg aaggccttga cttgaaagac aaaaatgccg tatttgaata
    24121 ttggcgaagt accaaacagg aggacttatc ggcagacggc aaagtcattt tgattccggc
    24181 ccaattgccg aatgtcgtca ccgtttcctc aataggtcca agcggaatga gatccgtctt
    24241 ttccaattat ggaaaaaatg tcgtcgacat tgcagccgat ggaggcgatc tccgtctttt
    24301 aaatgaagtg ggcgaggatc gatattacgg agaaggactg ttcaggcagg aatacattct
    24361 cggtgcagct cccggagtaa cctatacatt ctcaataggc acttcgatcg cggccccaaa
    24421 agtatccggc gctctggccc ttctgattga tcagaaacaa ttgcatgaca aaccagacaa
    24481 ggctgttaaa atcctgttaa aaaatgctga tcggaacgct gacaaaatag acaccggtgc
    24541 gggagtatta aatgtctatc gagcattgac tgattgagtg tgcgaaacta aaaagtttcc
    24601 cccttccctt tgaaaaagca aaagaactca ttggttcttt tgcttttttt atagctggac
    24661 cattatttta agcccgtttt cacacatcat ccggggggct ataccctctc gctgccctcc
    24721 ctctcctcaa cagcctcaat aaacgtttac agctccgcta agaggtcaaa ggaccaaggc
    24781 acaatcaaaa cattttcaga aggctgagaa ccgtctttta aaggcttttc tatgtctgct
    24841 tatcttatac aatcgtcgtg gcctccaatc aaatgatttg agagcatgta acatgctata
    24901 tttacgtttt taaaactgag gtgcacgggt acgttcttat tcgcatcgcg agtcagaagt
    24961 agagcgcgtt ttagaattga acggtattcc ggatctgctt caagtaaaaa tgaaaaataa
    25021 acgccggaaa attcaattga tcagtttcct tttatgcagt ttgaagcccg attttcagga
    25081 gaaggaaaag tccgaacaga taaagagatg tgaggcaatg aatggattgt ttcaatataa
    25141 ttggcaggtt cgcaatgaag ggtttgaatg gtgcttgcat cagttacaag aggaactcga
    25201 aaaaaggcat tcaggcggta tggaaagcat tttgaaaaac ttgtttcata ttgtcgatgt
    25261 tgaggtgagc tggatgtatg ccattttaga caagccggac ttcactcccg agttttccga
    25321 ctacccgtcg attcagcaca ttatcaggtt ttctgaagcg tatcgtcccg aagttgagag
    25381 cgtggttttt catttttcca gcgcagccga acaaaagcct gtcaaaacgt cttggtcaga
    25441 agatacctat acacaaagtg acatttta
//
