Select genomic region:
Overview
1.1
3.1
4.1
5.1
5.2
7.1
12.1
12.2
13.1
18.1
18.2
18.3
22.1
23.1
24.1
26.1
26.2
26.3
27.1
28.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_NKBC01000001.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii,cyclic-lactone-autoinducer | 1 | 25,468 | High | amyloliquecidin GF610 | ribosomal:RiPP

NZ_NKBC01000011.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | NRPS | 114,706 | 142,874 | Low | lichenysin | NRPS:Type I

NZ_NKBC01000012.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | terpene-precursor | 1 | 16,573 |

NZ_NKBC01000013.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 5.1 | NRP-metallophore,NRPS | 28,978 | 80,742 | High | bacillibactin/bacillibactin E/bacillibactin F | NRPS:Type I
Region 5.2 | lassopeptide | 178,834 | 201,567 |

NZ_NKBC01000015.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | T1PKS | 8,252 | 53,993 |  |

NZ_NKBC01000002.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | azole-containing-RiPP | 133,321 | 155,255 |  |
Region 12.2 | NI-siderophore | 285,611 | 319,074 | Medium | schizokinen | NRPS:Type IV

NZ_NKBC01000020.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 13.1 | NRPS | 197,738 | 223,174 | Medium | lichenysin | NRPS:Type I

NZ_NKBC01000025.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 18.1 | NRPS | 1 | 36,247 | Medium | bacitracin | NRPS:Type I
Region 18.2 | T3PKS | 169,083 | 210,180 |
Region 18.3 | terpene | 259,629 | 281,518 |

NZ_NKBC01000029.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 22.1 | NRPS | 1 | 15,432 | Low | fengycin | NRPS:Type I

NZ_NKBC01000003.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 23.1 | NRPS | 1 | 10,045 | Low | bacitracin | NRPS:Type I

NZ_NKBC01000004.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 24.1 | NRPS | 1 | 9,689 |  |

NZ_NKBC01000006.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 26.1 | NRPS | 1 | 34,207 | Low | bacitracin | NRPS:Type I
Region 26.2 | terpene-precursor | 63,663 | 84,553 |
Region 26.3 | RiPP-like | 128,039 | 138,383 |

NZ_NKBC01000007.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 27.1 | CDPS | 191,425 | 212,174 | Medium | pulcherriminic acid | other:other

NZ_NKBC01000008.1 (Bacillus paralicheniformis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 28.1 | NRPS,betalactone | 1 | 39,313 | Medium | fengycin | NRPS:Type I

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii,cyclic-lactone-autoinducer | 1 | 25,468 | High | amyloliquecidin GF610 | ribosomal:RiPP
Region 3.1 | NRPS | 114,706 | 142,874 | Low | lichenysin | NRPS:Type I
Region 4.1 | terpene-precursor | 1 | 16,573 |
Region 5.1 | NRP-metallophore,NRPS | 28,978 | 80,742 | High | bacillibactin/bacillibactin E/bacillibactin F | NRPS:Type I
Region 5.2 | lassopeptide | 178,834 | 201,567 |
Region 7.1 | T1PKS | 8,252 | 53,993 |  |
Region 12.1 | azole-containing-RiPP | 133,321 | 155,255 |  |
Region 12.2 | NI-siderophore | 285,611 | 319,074 | Medium | schizokinen | NRPS:Type IV
Region 13.1 | NRPS | 197,738 | 223,174 | Medium | lichenysin | NRPS:Type I
Region 18.1 | NRPS | 1 | 36,247 | Medium | bacitracin | NRPS:Type I
Region 18.2 | T3PKS | 169,083 | 210,180 |
Region 18.3 | terpene | 259,629 | 281,518 |
Region 22.1 | NRPS | 1 | 15,432 | Low | fengycin | NRPS:Type I
Region 23.1 | NRPS | 1 | 10,045 | Low | bacitracin | NRPS:Type I
Region 24.1 | NRPS | 1 | 9,689 |  |
Region 26.1 | NRPS | 1 | 34,207 | Low | bacitracin | NRPS:Type I
Region 26.2 | terpene-precursor | 63,663 | 84,553 |
Region 26.3 | RiPP-like | 128,039 | 138,383 |
Region 27.1 | CDPS | 191,425 | 212,174 | Medium | pulcherriminic acid | other:other
Region 28.1 | NRPS,betalactone | 1 | 39,313 | Medium | fengycin | NRPS:Type I

No secondary metabolite regions were found in these records:
  NZ_NKBC01000010.1 (Bacillus paralicheniformis)
  NZ_NKBC01000014.1 (Bacillus paralicheniformis)
  NZ_NKBC01000016.1 (Bacillus paralicheniformis)
  NZ_NKBC01000017.1 (Bacillus paralicheniformis)
  NZ_NKBC01000018.1 (Bacillus paralicheniformis)
  NZ_NKBC01000019.1 (Bacillus paralicheniformis)
  NZ_NKBC01000021.1 (Bacillus paralicheniformis)
  NZ_NKBC01000022.1 (Bacillus paralicheniformis)
  NZ_NKBC01000023.1 (Bacillus paralicheniformis)
  NZ_NKBC01000024.1 (Bacillus paralicheniformis)
  NZ_NKBC01000026.1 (Bacillus paralicheniformis)
  NZ_NKBC01000027.1 (Bacillus paralicheniformis)
  NZ_NKBC01000028.1 (Bacillus paralicheniformis)
  NZ_NKBC01000005.1 (Bacillus paralicheniformis)
  NZ_NKBC01000009.1 (Bacillus paralicheniformis)

Compact view
NZ_NKBC01000001.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 25,468 nt. (total: 25,468 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase protease
CE036_RS00010: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

CE036_RS00125: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
CE036_RS00065: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

CE036_RS00075: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002663.2 |  |  | 0.72 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0000517.4 |  |  | 0.54 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001229.4 |  |  | 0.44 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000525.5 |  |  | 0.43 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001311.5 |  |  | 0.37 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000554.4 |  |  | 0.36 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001391.3 |  |  | 0.33 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000497.3 |  |  | 0.32 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0001210.5 |  |  | 0.31 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002704.2 |  |  | 0.31 | ribosomal | archalan β | Halorussus salinus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002663.2 |  | 0.79 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0000517.4 |  | 0.65 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001229.4 |  | 0.60 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000504.5 |  | 0.56 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000626.3 |  | 0.55 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002110.3 |  | 0.54 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000552.3 |  | 0.54 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for CE036_RS00065

CE036_RS00060
Leader:
MSKIEAWKNPVARMNSQIVSPAGDLMDELSDSEMEMLAGG
Core:
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
Core with dehydrations:
Cys E W Y N I Dha Cys Q L G N K G Q W Cys Dhb L Dhb K E Cys Q R Dha Cys K

#### antiSMASH-DB 4.0 matches for CE036_RS00060

100.0%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
75.0%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
C W Y+I S C+L G N K G W C T L T E C Q S C
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C
27
72.4%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C+W+N I S C L G N G Q+C T L T K E C Q S C
1
C D W W N I S C H L G N T G Q F C T L T K E C Q P S C N
28
with 103 more sequence matches
Only the first 10 are displayed here.
67.9%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide
Lanthipeptides: IM743_RS02795_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C W Y++S C+L G N K G W C T L T E C Q +C
1
C A W Y D V S C R L G N K G A W C T L T V E C Q N N C N
28
65.5%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C+W+N I S C L G N G++C T L T K E C Q +C
1
C D W W N I S C H L G N T G R F C T L T K E C Q P N C N
28
62.5%
NC_002570.2 and 3 others:
NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide
Lanthipeptides: AYT26_RS02480_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C W Y N I S C+L G N K G +C T L T E C S C
5
C A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
32
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
3
W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
W+N+S L G N K G+ C T L T K E C Q C
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
60.0%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
4
Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
+ +S L G N K G W C T L T K E C Q R S C
6
F T L S D Y L G N K G G W C T L T K E C Q R S C
29
58.6%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide
Lanthipeptides: CN325_RS21835_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
C ++N I S C L G N G C T L T K E C+ +C
2
C N F W N I S C H L G N D G S V C T L T K E C R P A C
28
57.1%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
3
W Y N-I S C Q L G N K G Q W C T L T K E C Q R S C
27
W Y+ +S L G N+G +C T L T K E C Q C
2
W Y S E M S A A L G N R G S Y C T L T K E C Q A C C
27
57.1%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
3
W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
W ++S L G N K G C T L T K E C Q+ C+
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
56.7%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
4
Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
+ +S L G N G W C T L T K E C Q R S C
6
F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
53.6%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
6
I S C Q L G N K G Q W C T L T K E C Q R S C
27
+S +L G N G C T L T K E C Q R C
5
L S R K L G N T G Y V C T L T K E C Q R M C
26

#### MIBiG 4.0 matches for CE036_RS00060

71.4%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C W Y N I S C+L G N K G +C T L T E C S C
1
C A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
50.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
4
Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
+++S L G N G W C T L T K E C Q +C
6
F S L S N A L G N N G G W C T L T K E C Q P N C N
30
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
C T L T K E C Q R S C
27
C T L+K E C Q +C
28
C T L S K E C Q P N C
38
with 1 more sequence matches
10.7%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
23
C Q R S C
27
C++S C
1
C R Q S C
5
CE036_RS00070
Leader:
MSHREMAAIYRDANKRANLEFSNPVGEVNEEELKNLAGA
Core:
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
Core with dehydrations:
A D V Dhb P H Dhb Dhb P Dha Dha L P Cys G Dhb L V Dhb A V W Cys P Dha N A Cys Dhb Dha D Cys

#### antiSMASH-DB 4.0 matches for CE036_RS00070

100.0%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide
Lanthipeptides: BALI_RS00915_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
78.1%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
A D V T P H T T P S S L P C G V T A +C P S C T S C
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
56.2%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
D V P T T P S S+ C G V+A++C P+ C T S C
1
G D V D P Q T T P S S V A C G I A V S A L F C P T T K C T S Q C
32
with 115 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide
Lanthipeptides: C8268_RS00150_lanthipeptide
8
T P S S L P C G T L V T A V W C P S N A C T S D C
32
T S S C G V T A C P S A C T D C
8
T T S S W I C G-F V T A A L C P S T A C T G D C
31
46.9%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide
Lanthipeptides: CWT12_RS00390_lanthipeptide
7
T T P S S L P C G T L V T A V W C P S N A C T S D C
32
T T P S S P C G +T C P+ A C+S C
2
T T P S S W P C G I G I T T T V C P T A A C S S K C
27
46.9%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
7
T T P S S L P C G T L V T A V W C P S N A C T S D C
32
T T P S S P C G +T C P+ C T S C
2
T T P S S W P C G I G I T T T I C P T A V C T S K C
27
43.8%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
D V P T T P++ P V+ C P+ C T S C
1
G D V N P E T T P A T-P T I V A V S L G I C P T T K C T S K C
31
43.8%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
8
T P S S L P C G T L V T A V W C P S N A C T S D C
32
T S S C G + +A +C P S A C T S C
5
T T S S W I C G-V A S A A F C P S T A C T S K C
28
43.6%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
1
A D V T P H T T P---S S L P C---G T L V T A V W C P S N A C T S D C
32
D V P T T P S S P C ++A C P+ C T S C
2
G D V N P E T T P L T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
43.6%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide
Lanthipeptides: PDUR_RS29295_lanthipeptide
1
A D V T P H T T---P S S L P C---G T L V T A V W C P S N A C T S D C
32
D V P T T S S C G V+A C P+ C T S C
2
G D V N P E T T I L T T S S W T C I T A G V T V S A S L C P T T K C T S Q C
39
42.9%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
A D V T P H T T P S S---L P C G T L V T A V W C P S N A C T S D C
32
D V P T T P++ + V T A C P+ C T S C
1
G D V N P E T T P A T P T I I G A T I A V T A S L C P T T K C T S R C
35
41.2%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27165_lanthipeptide
Lanthipeptides: EXW52_RS27165_lanthipeptide
1
A D V T P H T T P S S L-P C G T L V T A V W C P S N A C T S D C
32
D V P T P++ P +T C P S C T S C
1
G D V N P E T I P A T A T P I L A N L T K E L C P S I P C T S R C
33
40.6%
NZ_CP036019.1 and 7 others:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide
Lanthipeptides: EXW52_RS27190_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
D V+P T T P++ ++ C P+N C T S C
1
G D V S P E T T P A T P T I V V A I S V G L C P T N R C T S K C
32

#### MIBiG 4.0 matches for CE036_RS00070

21.6%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
18
V T A V W C P S N A C T S D C
32
V+A +C P+ C T S C
23
V S A A F C P T T K C T S R C
37
18.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
W C P S N A C T S D C
32
+C P+ C T S C
16
F C P T T K C T S K C
26
11.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
8
T P S S L P C
14
T S S L P C
42
T L S S L P C
48
allorf_05089_05262
Leader:
MYCAVRSRKSCFSKEGKRRKKPKILGEVSFS
Core:
S F M R A I H K V F C K G K S V F S L F L F S I L V
Core with dehydrations:
Dha F M R A I H K V F Cys K G K Dha V F Dha L F L F Dha I L V

#### antiSMASH-DB 4.0 matches for allorf_05089_05262

100.0%
NC_021362.1 and 25 others:
NC_021362.1 Lanthipeptides: allorf_0175505_0175678_lanthipeptide NZ_AP025342.1 Lanthipeptides: allorf_1470598_1470771_lanthipeptide NZ_AP025342.1 Lanthipeptides: allorf_1470598_1470771_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: allorf_05598_05771_lanthipeptide NZ_CP010524.1 Lanthipeptides: allorf_0175655_0175828_lanthipeptide NZ_CP010524.1 Lanthipeptides: allorf_0175655_0175828_lanthipeptide NZ_CP020352.1 Lanthipeptides: allorf_0181382_0181555_lanthipeptide NZ_CP020352.1 Lanthipeptides: allorf_0181382_0181555_lanthipeptide NZ_CP023168.1 Lanthipeptides: allorf_0181439_0181612_lanthipeptide NZ_CP023168.1 Lanthipeptides: allorf_0181439_0181612_lanthipeptide NZ_CP118744.1 Lanthipeptides: allorf_0181347_0181520_lanthipeptide NZ_CP118744.1 Lanthipeptides: allorf_0181347_0181520_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: allorf_76220_76393_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: allorf_76220_76393_lanthipeptide NZ_KN125579.1 Lanthipeptides: allorf_0761255_0761428_lanthipeptide NZ_KN125579.1 Lanthipeptides: allorf_0761255_0761428_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: allorf_04826_04999_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: allorf_75882_76055_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: allorf_75882_76055_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: allorf_04794_04967_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: allorf_04794_04967_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: allorf_72951_73124_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: allorf_72951_73124_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: allorf_05089_05262_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: allorf_05067_05240_lanthipeptide
Lanthipeptides: allorf_0175505_0175678_lanthipeptide
1
S F M R A I H K V F C K G K S V F S L F L F S I L V
26
S F M R A I H K V F C K G K S V F S L F L F S I L V
1
S F M R A I H K V F C K G K S V F S L F L F S I L V
26
26.9%
NZ_AXVK01000021.1:
Lanthipeptides: K332_RS24275_lanthipeptide
11
C K G K S V F S L F L
21
C K +S S L F L
7
C K K E S T L S L F L
17
26.9%
NZ_JAMYIV010000006.1:
Lanthipeptides: allorf_139780_139899_lanthipeptide
9
V F C K G K S V F S L F
20
+ C K K S S L F
7
I N C K R K S T L S L F
18
with 3 more sequence matches
26.9%
NZ_JAOPTJ010000013.1:
Lanthipeptides: OCF64_RS23350_lanthipeptide
11
C K G K S V F S L F
20
C K K S S L F
7
C K E K S T I S L F
16
21.4%
NZ_CP050440.1 and 1 other:
NZ_CP050440.1 Lanthipeptides: HCG51_RS00710_lanthipeptide
Lanthipeptides: HCG51_RS00710_lanthipeptide
5
A I H K V F C K G K S V F
17
A V+C K G+S+
14
A N T S V W C K G E S M I
26
14.6%
NZ_CP096281.1:
Lanthipeptides: allorf_2545727_2545885_lanthipeptide
1
S F M R A I H K V F C K G K S V F S L F
20
+F+R + C+G S +F
7
T F V R P W A G I G C R G P S G V K I F
26

#### Lanthipeptide(s) for CE036_RS00075

CE036_RS00060
Leader:
MSKIEAWKNPVARMNSQIVSPAGDLMDELSDSEMEMLAGG
Core:
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
Core with dehydrations:
Cys E W Y N I Dha Cys Q L G N K G Q W Cys Dhb L Dhb K E Cys Q R Dha Cys K

#### antiSMASH-DB 4.0 matches for CE036_RS00060

100.0%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
75.0%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
C W Y+I S C+L G N K G W C T L T E C Q S C
1
C A W Y D I S C K L G N K G A W C T L T V E C Q S S C
27
72.4%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C+W+N I S C L G N G Q+C T L T K E C Q S C
1
C D W W N I S C H L G N T G Q F C T L T K E C Q P S C N
28
with 103 more sequence matches
Only the first 10 are displayed here.
67.9%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide
Lanthipeptides: IM743_RS02795_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C W Y++S C+L G N K G W C T L T E C Q +C
1
C A W Y D V S C R L G N K G A W C T L T V E C Q N N C N
28
65.5%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C+W+N I S C L G N G++C T L T K E C Q +C
1
C D W W N I S C H L G N T G R F C T L T K E C Q P N C N
28
62.5%
NC_002570.2 and 3 others:
NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide
Lanthipeptides: AYT26_RS02480_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C W Y N I S C+L G N K G +C T L T E C S C
5
C A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
32
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
3
W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
W+N+S L G N K G+ C T L T K E C Q C
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
60.0%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
4
Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
+ +S L G N K G W C T L T K E C Q R S C
6
F T L S D Y L G N K G G W C T L T K E C Q R S C
29
58.6%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide
Lanthipeptides: CN325_RS21835_lanthipeptide
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
C ++N I S C L G N G C T L T K E C+ +C
2
C N F W N I S C H L G N D G S V C T L T K E C R P A C
28
57.1%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
3
W Y N-I S C Q L G N K G Q W C T L T K E C Q R S C
27
W Y+ +S L G N+G +C T L T K E C Q C
2
W Y S E M S A A L G N R G S Y C T L T K E C Q A C C
27
57.1%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
3
W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
W ++S L G N K G C T L T K E C Q+ C+
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
56.7%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
4
Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
+ +S L G N G W C T L T K E C Q R S C
6
F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
53.6%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
6
I S C Q L G N K G Q W C T L T K E C Q R S C
27
+S +L G N G C T L T K E C Q R C
5
L S R K L G N T G Y V C T L T K E C Q R M C
26

#### MIBiG 4.0 matches for CE036_RS00060

71.4%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
C E W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
C W Y N I S C+L G N K G +C T L T E C S C
1
C A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
50.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
4
Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
+++S L G N G W C T L T K E C Q +C
6
F S L S N A L G N N G G W C T L T K E C Q P N C N
30
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
C T L T K E C Q R S C
27
C T L+K E C Q +C
28
C T L S K E C Q P N C
38
with 1 more sequence matches
10.7%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
23
C Q R S C
27
C++S C
1
C R Q S C
5
CE036_RS00070
Leader:
MSHREMAAIYRDANKRANLEFSNPVGEVNEEELKNLAGA
Core:
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
Core with dehydrations:
A D V Dhb P H Dhb Dhb P Dha Dha L P Cys G Dhb L V Dhb A V W Cys P Dha N A Cys Dhb Dha D Cys

#### antiSMASH-DB 4.0 matches for CE036_RS00070

100.0%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide
Lanthipeptides: BALI_RS00915_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
78.1%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
A D V T P H T T P S S L P C G V T A +C P S C T S C
1
A D V T P H T T P S S L P C G V F V T A A F C P S T K C T S S C
32
56.2%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
D V P T T P S S+ C G V+A++C P+ C T S C
1
G D V D P Q T T P S S V A C G I A V S A L F C P T T K C T S Q C
32
with 115 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide
Lanthipeptides: C8268_RS00150_lanthipeptide
8
T P S S L P C G T L V T A V W C P S N A C T S D C
32
T S S C G V T A C P S A C T D C
8
T T S S W I C G-F V T A A L C P S T A C T G D C
31
46.9%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide
Lanthipeptides: CWT12_RS00390_lanthipeptide
7
T T P S S L P C G T L V T A V W C P S N A C T S D C
32
T T P S S P C G +T C P+ A C+S C
2
T T P S S W P C G I G I T T T V C P T A A C S S K C
27
46.9%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
7
T T P S S L P C G T L V T A V W C P S N A C T S D C
32
T T P S S P C G +T C P+ C T S C
2
T T P S S W P C G I G I T T T I C P T A V C T S K C
27
43.8%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
D V P T T P++ P V+ C P+ C T S C
1
G D V N P E T T P A T-P T I V A V S L G I C P T T K C T S K C
31
43.8%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
8
T P S S L P C G T L V T A V W C P S N A C T S D C
32
T S S C G + +A +C P S A C T S C
5
T T S S W I C G-V A S A A F C P S T A C T S K C
28
43.6%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
1
A D V T P H T T P---S S L P C---G T L V T A V W C P S N A C T S D C
32
D V P T T P S S P C ++A C P+ C T S C
2
G D V N P E T T P L T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
43.6%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide
Lanthipeptides: PDUR_RS29295_lanthipeptide
1
A D V T P H T T---P S S L P C---G T L V T A V W C P S N A C T S D C
32
D V P T T S S C G V+A C P+ C T S C
2
G D V N P E T T I L T T S S W T C I T A G V T V S A S L C P T T K C T S Q C
39
42.9%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
A D V T P H T T P S S---L P C G T L V T A V W C P S N A C T S D C
32
D V P T T P++ + V T A C P+ C T S C
1
G D V N P E T T P A T P T I I G A T I A V T A S L C P T T K C T S R C
35
41.2%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27165_lanthipeptide
Lanthipeptides: EXW52_RS27165_lanthipeptide
1
A D V T P H T T P S S L-P C G T L V T A V W C P S N A C T S D C
32
D V P T P++ P +T C P S C T S C
1
G D V N P E T I P A T A T P I L A N L T K E L C P S I P C T S R C
33
40.6%
NZ_CP036019.1 and 7 others:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide
Lanthipeptides: EXW52_RS27190_lanthipeptide
1
A D V T P H T T P S S L P C G T L V T A V W C P S N A C T S D C
32
D V+P T T P++ ++ C P+N C T S C
1
G D V S P E T T P A T P T I V V A I S V G L C P T N R C T S K C
32

#### MIBiG 4.0 matches for CE036_RS00070

21.6%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
18
V T A V W C P S N A C T S D C
32
V+A +C P+ C T S C
23
V S A A F C P T T K C T S R C
37
18.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
W C P S N A C T S D C
32
+C P+ C T S C
16
F C P T T K C T S K C
26
11.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
8
T P S S L P C
14
T S S L P C
42
T L S S L P C
48
allorf_05089_05262
Leader:
MYCAVRSRKSCFSKEGKRRKKPKILGEVSFS
Core:
S F M R A I H K V F C K G K S V F S L F L F S I L V
Core with dehydrations:
Dha F M R A I H K V F Cys K G K Dha V F Dha L F L F Dha I L V

#### antiSMASH-DB 4.0 matches for allorf_05089_05262

100.0%
NC_021362.1 and 25 others:
NC_021362.1 Lanthipeptides: allorf_0175505_0175678_lanthipeptide NZ_AP025342.1 Lanthipeptides: allorf_1470598_1470771_lanthipeptide NZ_AP025342.1 Lanthipeptides: allorf_1470598_1470771_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: allorf_05598_05771_lanthipeptide NZ_CP010524.1 Lanthipeptides: allorf_0175655_0175828_lanthipeptide NZ_CP010524.1 Lanthipeptides: allorf_0175655_0175828_lanthipeptide NZ_CP020352.1 Lanthipeptides: allorf_0181382_0181555_lanthipeptide NZ_CP020352.1 Lanthipeptides: allorf_0181382_0181555_lanthipeptide NZ_CP023168.1 Lanthipeptides: allorf_0181439_0181612_lanthipeptide NZ_CP023168.1 Lanthipeptides: allorf_0181439_0181612_lanthipeptide NZ_CP118744.1 Lanthipeptides: allorf_0181347_0181520_lanthipeptide NZ_CP118744.1 Lanthipeptides: allorf_0181347_0181520_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: allorf_76220_76393_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: allorf_76220_76393_lanthipeptide NZ_KN125579.1 Lanthipeptides: allorf_0761255_0761428_lanthipeptide NZ_KN125579.1 Lanthipeptides: allorf_0761255_0761428_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: allorf_04826_04999_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: allorf_75882_76055_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: allorf_75882_76055_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: allorf_04794_04967_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: allorf_04794_04967_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: allorf_72951_73124_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: allorf_72951_73124_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: allorf_05089_05262_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: allorf_05067_05240_lanthipeptide
Lanthipeptides: allorf_0175505_0175678_lanthipeptide
1
S F M R A I H K V F C K G K S V F S L F L F S I L V
26
S F M R A I H K V F C K G K S V F S L F L F S I L V
1
S F M R A I H K V F C K G K S V F S L F L F S I L V
26
26.9%
NZ_AXVK01000021.1:
Lanthipeptides: K332_RS24275_lanthipeptide
11
C K G K S V F S L F L
21
C K +S S L F L
7
C K K E S T L S L F L
17
26.9%
NZ_JAMYIV010000006.1:
Lanthipeptides: allorf_139780_139899_lanthipeptide
9
V F C K G K S V F S L F
20
+ C K K S S L F
7
I N C K R K S T L S L F
18
with 3 more sequence matches
26.9%
NZ_JAOPTJ010000013.1:
Lanthipeptides: OCF64_RS23350_lanthipeptide
11
C K G K S V F S L F
20
C K K S S L F
7
C K E K S T I S L F
16
21.4%
NZ_CP050440.1 and 1 other:
NZ_CP050440.1 Lanthipeptides: HCG51_RS00710_lanthipeptide
Lanthipeptides: HCG51_RS00710_lanthipeptide
5
A I H K V F C K G K S V F
17
A V+C K G+S+
14
A N T S V W C K G E S M I
26
14.6%
NZ_CP096281.1:
Lanthipeptides: allorf_2545727_2545885_lanthipeptide
1
S F M R A I H K V F C K G K S V F S L F
20
+F+R + C+G S +F
7
T F V R P W A G I G C R G P S G V K I F
26

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (3):
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.79 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.12 out of 33.14
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.45 out of 35.63
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

CE036_RS00060 - Class II
  Cleavage pHMM score: 2.80
  RODEO score: 0
  Monoisotopic mass: 3236.5 Da
  Molecular weight: 3238.7 Da
  Number of bridges: 4
CE036_RS00070 - Class II
  Cleavage pHMM score: 3.70
  RODEO score: 0
  Monoisotopic mass: 3053.4 Da
  Molecular weight: 3055.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3073.4 Da N = 1
    3091.4 Da N = 2
    3109.5 Da N = 3
    3127.5 Da N = 4
    3145.5 Da N = 5
    3163.5 Da N = 6
allorf_05089_05262 - Class II
  Cleavage pHMM score: -4.70
  RODEO score: 0
  Monoisotopic mass: 2931.7 Da
  Molecular weight: 2933.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2951.6 Da N = 1
    2969.6 Da N = 2
    2987.7 Da N = 3
CE036_RS00060 - Class II
  Cleavage pHMM score: 2.80
  RODEO score: 0
  Monoisotopic mass: 3236.5 Da
  Molecular weight: 3238.7 Da
  Number of bridges: 4
CE036_RS00070 - Class II
  Cleavage pHMM score: 3.70
  RODEO score: 0
  Monoisotopic mass: 3053.4 Da
  Molecular weight: 3055.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3073.4 Da N = 1
    3091.4 Da N = 2
    3109.5 Da N = 3
    3127.5 Da N = 4
    3145.5 Da N = 5
    3163.5 Da N = 6
allorf_05089_05262 - Class II
  Cleavage pHMM score: -4.70
  RODEO score: 0
  Monoisotopic mass: 2931.7 Da
  Molecular weight: 2933.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2951.6 Da N = 1
    2969.6 Da N = 2
    2987.7 Da N = 3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_NKBC01000011.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 114,706 - 142,874 nt. (total: 28,169 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Translocases: transporter
CE036_RS11805: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.66 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.66 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.65 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.10 out of 27.55
Confidence: medium
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 114705 - 142874:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gln - Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS11825: Gln - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (465..868): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASVQQTDGLVGGETNVYGPTETCVDASS
  Nearest Stachelhaus code(s):
    Gln DAQDLGVVDK (100% 8Å match)
    Ile DAQDLGVVDK (76% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1511..1909): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNTSFDAFMFDGMILFGGELHMYGPSESTVFTTY
  Nearest Stachelhaus code(s):
    Leu DAFMLGMVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
ToxT | Regulator of MSHA biosynthesis

NZ_NKBC01000012.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,573 nt. (total: 16,573 nt) Show pHMM detection rules used
Region on contig edge.
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: esterase hydrolase
CE036_RS11840: isochorismatase

smcogs
  SMCOG1027: isochorismatase

CE036_RS11885: thioesterase superfamily protein

smcogs
  SMCOG1144: thioesterase superfamily protein

Ligases: synthetase
CE036_RS11865: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000516.4 |  | 0.44 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000205.3 |  | 0.35 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0000502.5 |  | 0.35 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000806.5 |  | 0.24 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0002364.2 |  | 0.24 | PKS | trichostatin RK | Streptomyces sp.
BGC0002476.2 |  | 0.23 | NRPS | enterobactin | Escherichia coli str. K-12 substr. MG1655
BGC0002300.2 |  | 0.21 | NRPS | albomycin delta2, albomycin delta1, albomycin epsilon | Streptomyces sp. ATCC 700974
BGC0002357.3 |  | 0.21 | PKS, other (other) | neomediomycin B | Streptomyces sp. RK95-74
BGC0001088.5 |  | 0.21 | NRPS, PKS | albicidin | Xanthomonas albilineans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000516.4 |  | 0.44 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000205.3 |  | 0.35 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0000502.5 |  | 0.35 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000806.5 |  | 0.24 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0002364.2 |  | 0.24 | PKS | trichostatin RK | Streptomyces sp.
BGC0002476.2 |  | 0.23 | NRPS | enterobactin | Escherichia coli str. K-12 substr. MG1655
BGC0002300.2 |  | 0.21 | NRPS | albomycin delta2, albomycin delta1, albomycin epsilon | Streptomyces sp. ATCC 700974
BGC0002357.3 |  | 0.21 | PKS, other (other) | neomediomycin B | Streptomyces sp. RK95-74
BGC0001088.5 |  | 0.21 | NRPS, PKS | albicidin | Xanthomonas albilineans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
CE036_RS11865: PT_FPPS_like
Domain 1 (41 - 287): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.35 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.58 out of 26.06
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.57 out of 33.14
Confidence: medium
Additional weak hits (7):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.80 out of 30.22
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.16 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.72 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.06 out of 29.25
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.33 out of 26.06
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.37 out of 30.22
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 2 | Zinc-responsive repressor

NZ_NKBC01000013.1 - Region 1 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 28,978 - 80,742 nt. (total: 51,765 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase electron transfer
CE036_RS12780: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CE036_RS12855: flavodoxin

smcogs
  SMCOG1134: flavodoxin

Transferases: acetyltransferase
CE036_RS12820: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase
CE036_RS12765: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Lyases: dehydratase
CE036_RS12690: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: isomerase
CE036_RS12775: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
CE036_RS12760: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CE036_RS12770: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002695.2 |  |  | 1.14 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0000309.5 |  |  | 1.07 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5 |  |  | 1.06 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000401.5 |  |  | 1.06 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  | 0.87 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  | 0.86 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  | 0.76 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.75 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002695.2 |  | 0.82 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0000309.5 |  | 0.81 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5 |  | 0.80 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.75 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.42 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.80 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.67 out of 20.97
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.66 out of 29.38
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.44 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.21 out of 28.19
Confidence: medium
Additional weak hits (14):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.03 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.36 out of 32.74
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.34 out of 29.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.57 out of 33.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.61 out of 30.25
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 20.57 out of 30.12
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.73 out of 28.14
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.33 out of 20.01
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.18 out of 29.25
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 28977 - 80742:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS12760: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (465..861): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISALELQALVGGETNLYGPTETTIWSTA
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1521..1937): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQIFGGEINMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

CE036_RS12770: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SVSLYPLSSPGGGLQVGGAQQVYGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (91% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_NKBC01000013.1 - Region 2 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 178,834 - 201,567 nt. (total: 22,734 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
CE036_RS13425: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: dehydratase
CE036_RS13465: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001552.3 |  | 0.50 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001634.3 |  | 0.50 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001549.3 |  | 0.49 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0002289.2 |  | 0.48 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii
BGC0001551.4 |  | 0.48 | ribosomal | citrulassin E | Streptomyces glaucescens
BGC0001639.3 |  | 0.46 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002064.2 |  | 0.45 | ribosomal | felipeptin A2, felipeptin A1 | Amycolatopsis sp. YIM 10
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0002425.3 |  | 0.41 | ribosomal | stlassin | Streptomyces sp.
BGC0002577.2 |  | 0.41 | ribosomal | lactococcin G | Lactococcus lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001552.3 |  | 0.50 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001634.3 |  | 0.50 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001549.3 |  | 0.49 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0002289.2 |  | 0.48 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii
BGC0001551.4 |  | 0.48 | ribosomal | citrulassin E | Streptomyces glaucescens
BGC0001639.3 |  | 0.46 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002064.2 |  | 0.45 | ribosomal | felipeptin A2, felipeptin A1 | Amycolatopsis sp. YIM 10
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0002425.3 |  | 0.41 | ribosomal | stlassin | Streptomyces sp.
BGC0002577.2 |  | 0.41 | ribosomal | lactococcin G | Lactococcus lactis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lassopeptide(s) for allorf_192723_192848

allorf_192723_192848
Leader:
MTQMRKLESAQVKNYGTFLTVTL
Full core:
S K K S K P G D G K F G R G V K R G
Putative macrolactam:
S K K S K P G D

#### antiSMASH-DB 4.0 matches for allorf_192723_192848

100.0%
NC_006322.1 and 72 others:
NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptide NZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptide NZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptide NZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptide NZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptide NZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptide NZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptide NZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptide NZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptide NZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptide NZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptide NZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptide NZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptide NZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptide NZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptide NZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptide NZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptide NZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptide NZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptide NZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptide NZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptide NZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptide NZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptide NZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptide NZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptide NZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptide NZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptide NZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptide NZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptide NZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptide NZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptide NZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptide NZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptide NZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptide NZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptide NZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptide NZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptide NZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptide NZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptide NZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptide NZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptide NZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptide NZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptide NZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptide NZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptide NZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptide NZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptide NZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptide NZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptide NZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptide NZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptide NZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptide NZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptide NZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptide NZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptide NZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptide NZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptide NZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptide NZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptide NZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptide NZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptide NZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptide NZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptide NZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptide NZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptide NZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptide NZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptide NZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptide NZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptide NZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptide NZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptide NZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide
Lassopeptides: allorf_3863359_3863484_lassopeptide
1
S K K S K P G D G K F G R G V K R G
18
S K K S K P G D G K F G R G V K R G
1
S K K S K P G D G K F G R G V K R G
18
83.3%
NZ_CP023481.1 and 1 other:
NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide
Lassopeptides: allorf_2680773_2680886_lassopeptide
1
S K K S K P G D G K F G R G V K
16
S K K S K P G D G K F G R G K
1
S K K S K P G D G K F G R G K K
16
57.1%
NZ_NBBB01000032.1 and 3 others:
NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide
Lassopeptides: allorf_06132_06263_lassopeptide
1
S K K S K P G D G K F G R G V K R G
18
+K K P G D G K G+G K R G
1
A K S G K P G D G K H G K G-K R G
17
with 4 more sequence matches
50.0%
NZ_CP036072.1 and 6 others:
NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide
Lassopeptides: allorf_073459_073575_lassopeptide
1
S K K S K P G D G K F G R G V K R
17
+K K P G D G +G V+R
1
A K T K K P G D G T R A K G V R R
17
47.4%
NZ_CP036072.1 and 20 others:
NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide
Lassopeptides: allorf_073304_073423_lassopeptide
1
S K K S K P G D G K F G R G V K R G
18
+K K+K P G D G +G+++G
1
A K K N K P G D G T R T K G I R K G
18
42.9%
NZ_CP085880.1:
Lassopeptides: FH508_RS23935_lassopeptide
1
S K K S K P G D G
9
S K K S K P G D G
1
S K K S K P G D G
9
21.9%
NZ_CP084203.1:
Lanthipeptides: allorf_0587605_0587784_lanthipeptide
1
S K K S K P G D G K F G R G V K R G
18
++++ P G D G R V G
15
A E R A V P G D D G P G R A V S A G
32

#### MIBiG 4.0 matches for allorf_192723_192848

66.7%
BGC0002150.2 (MBO0654592.1):
Lasso peptide: triculamin
1
S K K S K P G D G K F G R G V K
16
S K K S K P G D G G+G V+
1
S K K S K P G D G I R G K G V R
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.12 out of 23.79
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 27.50 out of 30.25
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.15 out of 20.97
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.79 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.30 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.26 out of 28.19
Confidence: medium
Additional weak hits (4):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.01 out of 30.11
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.74 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.83 out of 29.38
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.25 out of 29.25
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_192723_192848 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 16
  Monoisotopic mass: 1870.1 Da
  Molecular weight: 1871.1 Da
  Number of bridges: 0

RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (178833...201567)
CE036_RS13435
  RRE type: Stand_Alone_Lasso_RRE
  Location: 4 - 86
  Score: 32.5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_NKBC01000015.1 - Region 1 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 8,252 - 53,993 nt. (total: 45,742 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase
CE036_RS16525: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase protease
CE036_RS16660: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

CE036_RS16710: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: dehydratase
CE036_RS16540: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase
CE036_RS16590: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease
CE036_RS16550: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000056.3 |  | 0.69 | PKS | esperamicin | Actinomadura verrucosospora
BGC0001160.5 |  | 0.54 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0002387.2 |  | 0.50 | PKS | yangpumicin A | Micromonospora yangpuensis
BGC0002545.3 |  | 0.49 | PKS | sungeidine C, sungeidine B, sungeidine D, sungeidine H, sungeidine A, sungeidine E, sungeidine F, sungeidine G | Micromonospora sp.
BGC0001377.5 |  | 0.46 | PKS | uncialamycin | Streptomyces uncialis
BGC0002103.2 |  | 0.43 | other (other) | pulcherriminic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0001747.3 |  | 0.43 | other (other) | pseudaminic acid | Tannerella forsythia
BGC0000595.3 |  | 0.43 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000597.4 |  | 0.42 | ribosomal | SWA-2138 | Streptomyces sp. e14
BGC0001060.5 |  | 0.42 | PKS | dynemicin A | Micromonospora chersina

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000056.3 |  | 0.69 | PKS | esperamicin | Actinomadura verrucosospora
BGC0001160.5 |  | 0.54 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0002387.2 |  | 0.50 | PKS | yangpumicin A | Micromonospora yangpuensis
BGC0002545.3 |  | 0.49 | PKS | sungeidine C, sungeidine B, sungeidine D, sungeidine H, sungeidine A, sungeidine E, sungeidine F, sungeidine G | Micromonospora sp.
BGC0001377.5 |  | 0.46 | PKS | uncialamycin | Streptomyces uncialis
BGC0002103.2 |  | 0.43 | other (other) | pulcherriminic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0001747.3 |  | 0.43 | other (other) | pseudaminic acid | Tannerella forsythia
BGC0000595.3 |  | 0.43 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000597.4 |  | 0.42 | ribosomal | SWA-2138 | Streptomyces sp. e14
BGC0001060.5 |  | 0.42 | PKS | dynemicin A | Micromonospora chersina

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.43 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.84 out of 20.97
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.31 out of 25.88
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.78 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.81 out of 27.78
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
Additional weak hits (7):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.12 out of 30.25
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 25.14 out of 35.63
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.67 out of 32.38
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.16 out of 27.55
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS16590: mal
PKS_AT (606..845): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 79.2%
  inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 62.9
  inactive: 44.8
  Methoxymalonyl-CoA: 35.1
  Methylmalonyl-CoA: 22.0
  Propionyl-CoA: 11.9
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_NKBC01000002.1 - Region 1 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 133,321 - 155,255 nt. (total: 21,935 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase
CE036_RS01210: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.45 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001555.4 |  | 0.41 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000519.4 |  | 0.41 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.45 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001555.4 |  | 0.41 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000519.4 |  | 0.41 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.02 out of 26.06
Confidence: medium
Additional weak hits (7):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.97 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.97 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.69 out of 31.73
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.69 out of 21.55
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.62 out of 30.97
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.17 out of 32.93
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.00 out of 33.14
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (133320...155255)
CE036_RS01255
  RRE type: Heterocycloanthracin_C_RRE
  Location: 0 - 100
  Score: 171.5
  RRE type: Thiopeptide_F_RRE
  Location: 7 - 89
  Score: 47.5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_NKBC01000002.1 - Region 2 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 285,611 - 319,074 nt. (total: 33,464 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
CE036_RS01945: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

CE036_RS01995: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

CE036_RS02010: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase aminotransferase
CE036_RS01935: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

CE036_RS01970: aminotransferase

smcogs
  SMCOG1019: aminotransferase

CE036_RS01975: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Lyases: decarboxylase
CE036_RS01980: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002633.2 |  | 0.65 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0001499.5 |  | 0.63 | other (other) | aerobactin | Pantoea ananatis
BGC0002683.2 |  | 0.63 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002469.2 |  | 0.63 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.3 |  | 0.59 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002470.2 |  | 0.57 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002
BGC0002305.2 |  | 0.57 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002692.2 |  | 0.57 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002633.2 |  | 0.65 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0001499.5 |  | 0.63 | other (other) | aerobactin | Pantoea ananatis
BGC0002683.2 |  | 0.63 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002469.2 |  | 0.63 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.3 |  | 0.59 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002470.2 |  | 0.57 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002
BGC0002305.2 |  | 0.57 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002692.2 |  | 0.57 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 23.61 out of 25.88
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 26.06 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.75 out of 26.06
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.51 out of 23.79
Confidence: medium
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.29 out of 30.11
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.57 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.42 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
Additional weak hits (13):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.18 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.18 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.11 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.22 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.17 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.69 out of 26.06
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 20.57 out of 30.12
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.23 out of 30.11
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.17 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.93 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.46 out of 29.38
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.89 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CelR | Cellobiose uptake repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_NKBC01000020.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 197,738 - 223,174 nt. (total: 25,437 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase aminotransferase
CE036_RS18450: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

CE036_RS18515: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

CE036_RS18520: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: esterase
CE036_RS18530: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: decarboxylase
CE036_RS18480: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase
CE036_RS18535: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CE036_RS18540: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Translocases: permease
CE036_RS18445: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.36 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.70 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.22 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.77 out of 20.97
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 26.33
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.22 out of 28.19
Confidence: medium
Additional weak hits (6):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.03 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.59 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.58 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.31 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.29 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 197737 - 223174:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS18535: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (472..870): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VETSFDGFTFDGFVLFGGEIHVYGPTETTVFATF
  Nearest Stachelhaus code(s):
    Ile DGFFLGVVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN | Regulator of nitrogen assimilation and virulence
ZuR variant 1 | Zinc-responsive repressor

NZ_NKBC01000025.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 36,247 nt. (total: 36,247 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
CE036_RS20490: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.67 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.66 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.65 | NRPS | HC-toxin | Alternaria jesenskae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.67 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.66 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.65 | NRPS | HC-toxin | Alternaria jesenskae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.97 out of 24.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.72 out of 24.78
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.35 out of 18.16
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.10 out of 24.78
Confidence: medium
Additional weak hits (4):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.44 out of 33.14
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.86 out of 29.65
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.48 out of 32.38
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 36247:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Phe - His - D-Asp - Asn)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS20490: Phe - His - Asp - Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (556..946): Phe
nrpys: Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LAVAFDASAFEPTLVSAGSINAYGPTETTVCATA
  Nearest Stachelhaus code(s):
    Phe DAFTVAAVCK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2060..2451): His
nrpys: His

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRPFDSSVEDTLATVAGEFNEYGPTENSVCSTR
  Nearest Stachelhaus code(s):
    His DSELTAEVCK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3092..3494): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTSSKLVLGGEMNHYGPTETTIGSVF
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4607..5000): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEYNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_NKBC01000025.1 - Region 2 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 169,083 - 210,180 nt. (total: 41,098 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase methyltransferase
CE036_RS21465: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

CE036_RS21475: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Ligases: synthase
CE036_RS21470: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.44 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001475.4 |  | 0.42 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001928.2 |  | 0.32 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001964.2 |  | 0.32 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002254.3 |  | 0.31 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0002034.3 |  | 0.30 | other (other) | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0001663.3 |  | 0.30 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.44 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001475.4 |  | 0.42 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001928.2 |  | 0.32 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001964.2 |  | 0.32 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002254.3 |  | 0.31 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0002034.3 |  | 0.30 | other (other) | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0001663.3 |  | 0.30 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.32 out of 23.79
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.55 out of 27.78
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.91 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.26 out of 29.38
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.45 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.87 out of 20.97
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.26 out of 27.78
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.57 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.50 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.03 out of 32.93
Confidence: medium
Additional weak hits (20):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.57 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.48 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.65 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.98 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.98 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.19 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.10 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.63 out of 33.14
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.98 out of 29.65
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.49 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.19 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.25 out of 33.14
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.94 out of 35.63
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.97 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
IolR | Regulator of the inositol catabolism
LexA variant 3 | Repressor of DNA damage response
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_NKBC01000025.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 259,629 - 281,518 nt. (total: 21,890 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
CE036_RS21945: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: acetyltransferase
CE036_RS21935: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase
CE036_RS21970: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000948.5 |  | 0.52 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002006.2 |  | 0.36 | ribosomal | albusnodin | Streptomyces albus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0001575.4 |  | 0.35 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0000663.5 |  | 0.34 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001338.4 |  | 0.34 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.34 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001925.4 |  | 0.34 | other (other) | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001736.3 |  | 0.34 | NRPS | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000948.5 |  | 0.52 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002006.2 |  | 0.36 | ribosomal | albusnodin | Streptomyces albus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0001575.4 |  | 0.35 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0000663.5 |  | 0.34 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001338.4 |  | 0.34 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.34 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001925.4 |  | 0.34 | other (other) | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001736.3 |  | 0.34 | NRPS | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
CE036_RS21925: T2TS
Domain 1 (4 - 625): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.26 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.78 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.00 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
Additional weak hits (7):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.21 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.82 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.22 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.11 out of 26.06
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.05 out of 25.75
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.06 out of 25.88
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.42 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_NKBC01000029.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 15,432 nt. (total: 15,432 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
CE036_RS22345: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CE036_RS22350: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CE036_RS22355: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.73 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000426.5 |  | 0.67 | NRPS | sevadicin | Paenibacillus larvae
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.66 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002164.2 |  | 0.66 | NRPS | peramine | Epichloe festucae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.73 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000426.5 |  | 0.67 | NRPS | sevadicin | Paenibacillus larvae
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.66 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002164.2 |  | 0.66 | NRPS | peramine | Epichloe festucae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 15432:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS22350: Tyr - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (474..867): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGSITGTLFTFAGEINEYGPTENSVSTTV
  Nearest Stachelhaus code(s):
    Tyr DGTLTAEVAK (82% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (1510..1906): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHDHFDFSVWEGNQIFGGEINMYGITEITVHATY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

CE036_RS22355: Glu - Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (1..373): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1005..1409): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    AAWAFDVFSGDRESILGSDINSYGVTEATIDSSY
  Nearest Stachelhaus code(s):
    Orn DVGEIGSIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_NKBC01000003.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 10,045 nt. (total: 10,045 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
CE036_RS03480: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CE036_RS03485: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0000426.5 |  | 0.68 | NRPS | sevadicin | Paenibacillus larvae
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001133.4 |  | 0.66 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.65 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.65 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  | 0.65 | NRPS | HC-toxin | Alternaria jesenskae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0000426.5 |  | 0.68 | NRPS | sevadicin | Paenibacillus larvae
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001133.4 |  | 0.66 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.65 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.65 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  | 0.65 | NRPS | HC-toxin | Alternaria jesenskae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 10045:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Lys - D-Orn)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS03480: Lys - Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (523..911): Lys
nrpys: Lys

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    N/A
  Single AA prediction:
    lys (Lys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YAFVFDAFSEEPSCISGGDYNSYGPTEATVCATY
  Nearest Stachelhaus code(s):
    Lys DAESIGSVCK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1553..1955): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    ATWAFDVFAGDRESIMGSDINSYGVTEASVDSGY
  Nearest Stachelhaus code(s):
    Orn DVGEIGSVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_NKBC01000004.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 9,689 nt. (total: 9,689 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
CE036_RS03490: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.70 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.70 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 9689:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val - Asp)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS03495: Val - Asp
Search NORINE for peptide: strict or relaxed
AMP-binding (470..862): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNAGFDASTFEGWLIIGGDWNGYGPTENTTFSTC
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1903): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTSPKLVLGGEINHYGPTETTIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_NKBC01000006.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 34,207 nt. (total: 34,207 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
CE036_RS03810: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CE036_RS03830: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Hydrolases: deacetylase esterase hydrolase
CE036_RS03790: thioesterase

smcogs
  SMCOG1004: thioesterase

CE036_RS03815: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

CE036_RS03825: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Ligases: ligase
CE036_RS03785: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001641.4 |  | 0.67 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001641.4 |  | 0.67 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.20 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.19 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.09 out of 26.06
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.19 out of 28.19
Confidence: strong
Additional weak hits (8):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.22 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.99 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.46 out of 29.25
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.43 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 34207:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ile - Cys - Leu - D-Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS03785: Ile - Cys - Leu - Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (42..437): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VNTSFDGSVFDGFILFGGEIHVYGPTESTVYATY
  Nearest Stachelhaus code(s):
    Ile DGFFLGVVYK (100% 8Å match)
    Leu DGFFLGVVYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1095..1474): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNSLLSGDISLGGATEGSIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2130..2514): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDAFVWEPFLLTGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3155..3556): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASVKQADMIVGGDTNVYGPTECCVDAAS
  Nearest Stachelhaus code(s):
    Glu DAKDIGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_NKBC01000006.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 63,663 - 84,553 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
CE036_RS04100: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
CE036_RS04065: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

CE036_RS04070: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
CE036_RS04070: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.93 out of 28.19
Confidence: medium
Additional weak hits (2):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.80 out of 30.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_NKBC01000006.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 128,039 - 138,383 nt. (total: 10,345 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.61 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002447.3 |  | 0.50 | ribosomal | cerecyclin | Bacillus cereus
BGC0000558.5 |  | 0.43 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000491.5 |  | 0.40 | ribosomal | gassericin A | Lactobacillus gasseri
BGC0001222.3 |  | 0.40 | ribosomal | acidocin B | Lactobacillus acidophilus
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001779.5 |  | 0.37 | ribosomal | siamycin | Streptomyces nodosus
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002488.3 |  | 0.35 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.61 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002447.3 |  | 0.50 | ribosomal | cerecyclin | Bacillus cereus
BGC0000558.5 |  | 0.43 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000491.5 |  | 0.40 | ribosomal | gassericin A | Lactobacillus gasseri
BGC0001222.3 |  | 0.40 | ribosomal | acidocin B | Lactobacillus acidophilus
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001779.5 |  | 0.37 | ribosomal | siamycin | Streptomyces nodosus
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002488.3 |  | 0.35 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.02 out of 20.97
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.07 out of 18.16
Confidence: strong
Additional weak hits (2):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.31 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.22 out of 30.11
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A

NZ_NKBC01000007.1 - Region 1 - CDPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 191,425 - 212,174 nt. (total: 20,750 nt) Show pHMM detection rules used
CDPS: CDPS

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
CE036_RS08285: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CE036_RS08305: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

CE036_RS08325: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: kinase
CE036_RS08270: glycerol kinase

smcogs
  SMCOG1210: glycerol kinase

Hydrolases: amidase
CE036_RS08320: amidase

smcogs
  SMCOG1105: amidase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | CDPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002103.2 |  | 0.66 | other (other) | pulcherriminic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0000866.5 |  | 0.45 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0002482.2 |  | 0.40 | other (other) | tjipanazole D, tjipanazole I, tjipanazole L, tjipanazole K, tjipanazole M | Symphyonema bifilamentata 97.28
BGC0000622.5 |  | 0.39 | ribosomal | megacin | Bacillus megaterium
BGC0002621.2 |  | 0.37 | other (other) | angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine | Streptomyces angustmyceticus
BGC0000720.3 |  | 0.37 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000719.5 |  | 0.37 | saccharide | tobramycin | Streptoalloteichus hindustanus
BGC0002234.3 |  | 0.36 | PKS | flavoglaucin | Aspergillus ruber CBS 135680
BGC0002594.2 |  | 0.36 | PKS | orcinol, orsellinic acid | Fusarium graminearum PH-1
BGC0000193.3 |  | 0.36 | PKS | aclacinomycin | Streptomyces galilaeus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002103.2 |  | 0.66 | other (other) | pulcherriminic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0000866.5 |  | 0.45 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0002482.2 |  | 0.40 | other (other) | tjipanazole D, tjipanazole I, tjipanazole L, tjipanazole K, tjipanazole M | Symphyonema bifilamentata 97.28
BGC0000622.5 |  | 0.39 | ribosomal | megacin | Bacillus megaterium
BGC0002621.2 |  | 0.37 | other (other) | angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine | Streptomyces angustmyceticus
BGC0000720.3 |  | 0.37 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000719.5 |  | 0.37 | saccharide | tobramycin | Streptoalloteichus hindustanus
BGC0002234.3 |  | 0.36 | PKS | flavoglaucin | Aspergillus ruber CBS 135680
BGC0002594.2 |  | 0.36 | PKS | orcinol, orsellinic acid | Fusarium graminearum PH-1
BGC0000193.3 |  | 0.36 | PKS | aclacinomycin | Streptomyces galilaeus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.26 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.79 out of 24.78
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.31 out of 25.88
Confidence: medium
Additional weak hits (5):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.86 out of 26.33
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.21 out of 28.14
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.17 out of 27.55
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.45 out of 29.25
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
PsrA | Oleic acid responsive regulator

NZ_NKBC01000008.1 - Region 1 - NRPS,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 39,313 nt. (total: 39,313 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase transferase
CE036_RS08795: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

CE036_RS08815: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: hydratase
CE036_RS08810: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
CE036_RS08780: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CE036_RS08785: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CE036_RS08790: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CE036_RS08805: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

CE036_RS08820: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001132.4 |  |  | 0.83 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.82 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.81 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002135.2 |  |  | 0.80 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  | 0.78 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.77 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  |  | 0.76 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001050.5 |  |  | 0.76 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0001261.3 |  |  | 0.74 | NRPS | AM-toxin | Alternaria alternata
BGC0001758.4 |  |  | 0.74 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002135.2 |  | 0.72 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.70 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001050.5 |  | 0.70 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.05 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97
Confidence: strong
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.21 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.81 out of 28.19
Confidence: medium
Additional weak hits (7):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.85 out of 39.62
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.20 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.44 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.11 out of 31.73
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.58 out of 32.93
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.96 out of 23.43
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 39313:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Val) + (Pro - Gln - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CE036_RS08780: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (518..909): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSAFDAMTFEGWLILGGEWNGYGPTENTTFSTC
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

CE036_RS08785: Pro - Gln - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (470..870): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDQAFDVCYQETFFITAGEHNHYGPAETHVVSTC
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1503..1901): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
  Nearest Stachelhaus code(s):
    Gln DAWHFGSVEK (100% 8Å match)
    Glu DAWHFGSVEK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2531..2924): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRSFDAFVTSANLTLGGESNEYGPTESSITATA
  Nearest Stachelhaus code(s):
    Thr DAYNTGLIHK (53% 8Å match)
  Stachelhaus code match:
    70% (weak)

CE036_RS08790: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (474..865): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSGFDAITFEGFLYVGGEYNIYGPTENTTFSTF
  Nearest Stachelhaus code(s):
    Ile DAFFYGITFK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

CE036_RS08820: X
AMP-binding (97..524): X
nrpys: Phe, Trp

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    KFDTWMMGPFLGGVGSTGEFNYSGGTEISGGILG
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor