LOCUS       NZ_NKAX01000026        26444 bp    DNA     linear   CON 03-APR-2024
DEFINITION  Bacillus cereus strain 32-6 32-6_R1_(paired)_contig_26, whole genome
            shotgun sequence.
ACCESSION   NZ_NKAX01000026
VERSION     NZ_NKAX01000026.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus cereus
  ORGANISM  Bacillus cereus
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 73295)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 73295)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009935145.1-RS_2024_04_03
            Annotation Date                   :: 04/03/2024 04:19:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,979
            CDSs (total)                      :: 5,895
            Genes (coding)                    :: 5,727
            CDSs (with protein)               :: 5,727
            Genes (RNA)                       :: 84
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 76
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 168
            CDSs (without protein)            :: 168
            Pseudo Genes (ambiguous residues) :: 0 of 168
            Pseudo Genes (frameshifted)       :: 62 of 168
            Pseudo Genes (incomplete)         :: 100 of 168
            Pseudo Genes (internal stop)      :: 56 of 168
            Pseudo Genes (multiple problems)  :: 40 of 168
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:34
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3379
            Orig. end                         :: 29823
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NKAX01000026.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26444
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26444
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26444
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16444](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16444
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(230..246)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 23.4"
                     /tool="antismash"
     gene            345..716
                     /locus_tag="CE086_RS26105"
     CDS             345..716
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017763509.1"
                     /locus_tag="CE086_RS26105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_000800772.1"
                     /transl_table=11
                     /translation="MKNYIQGIDHVQVAAPVGCEEEARDFYGNTIGMEEIPKPEELKKR
                     GGCWFKCGNQEIHIGVERNFTPAKKAHPAFYVNEINEFKQTLIEQGVKVIDDYARPDVI
                     RFYVSDPFGNRIEFMQNKD"
     gene            complement(736..1545)
                     /locus_tag="CE086_RS26110"
     CDS             complement(736..1545)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000251344.1"
                     /locus_tag="CE086_RS26110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YitT family protein"
                     /protein_id="WP_000251344.1"
                     /transl_table=11
                     /translation="MVRFLGVIIGSIIIAVAFNLFLIPHKILSSGIGGIAIILGIVTPV
                     NTGIINFVLNLPILILGYIGLGKKVIFNTVVSVVVLSVALYYVPVKVVATDPLLSSIFG
                     GVIAGAGIGLVFNCNGSTGGFDIIGMLLSRKRDIKLGGFLIILNAVVVIIAGFFFTWDV
                     ALTSLLSIYVTGKVIDAVHTKHRKVTLMIVTNEAEKMKKQLLSTVVRGITLLDGEGAYS
                     SEKKRVLMTVVSREELASMKLTISEIDPNAFVNITETVEVLGLFRRS"
     gene            1672..2493
                     /locus_tag="CE086_RS26115"
     CDS             1672..2493
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002028193.1"
                     /locus_tag="CE086_RS26115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protein phosphatase 2C domain-containing protein"
                     /protein_id="WP_140157221.1"
                     /transl_table=11
                     /translation="MKGDTVVKIKTYQQKSPLKQECEDSYFCNKEKKIYGVCDGATPLV
                     PFRDEKGHNGAYIASHLFASYFTALRENHSLQFAVAKANEALQSKMLEYEVDTRKKEHL
                     WCTCIAAVQIVGEKIEYAQLGDCMIVATFQNGTMQVLTKDTVEGISKRAKKKREEDRKK
                     GLSVPEEYVFQDVREQLKYNRYLANMPDGYSVANGMKEAIHYLQHGELHTDEVSGIFIC
                     SDGLFHPDWSLEQTVAYIRKNSINEYIAIIEELEAEKRIRPDDKTIIMIDF"
     gene            2509..2961
                     /locus_tag="CE086_RS26120"
     CDS             2509..2961
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402975.1"
                     /locus_tag="CE086_RS26120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidoglycan recognition family protein"
                     /protein_id="WP_000403999.1"
                     /transl_table=11
                     /translation="MEIKRVNLTFQDELVPLEKVNKLIIHHTAEDGWDVYKTHEFHQTV
                     RGWSGIGYNYFIEKDGTVVEGRGLHIGAHAKDHNRHTIGICMTGNFDKYDPTPAQVNAL
                     YSLCKLFMKQFAIKKENILGHRELEGVTKSCPGNRFSMVELRKILS"
     gene            2981..3229
                     /locus_tag="CE086_RS26125"
     CDS             2981..3229
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000981064.1"
                     /locus_tag="CE086_RS26125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2164 domain-containing protein"
                     /protein_id="WP_000981064.1"
                     /transl_table=11
                     /translation="MMNIKIPNDKKEELVAQIQQFFMEEDLDEIGRFQAERLIEEMIKL
                     VGPFAYNQAIGDARKLVSEKLTNIEEDLYVLEKNEGK"
     gene            complement(3254..3466)
                     /locus_tag="CE086_RS26130"
     CDS             complement(3254..3466)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000160420.1"
                     /locus_tag="CE086_RS26130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CsbD family protein"
                     /protein_id="WP_000160410.1"
                     /transl_table=11
                     /translation="MTKHDHGLKEKVEGAIDKVKGEVKEVVGKVTDNKKLQAEGKWDKV
                     KGTAKDTVGNVKEKVHEYKEHKKEK"
     misc_feature    3503..3515
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            complement(3638..4444)
                     /locus_tag="CE086_RS26135"
     CDS             complement(3638..4444)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000214346.1"
                     /locus_tag="CE086_RS26135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_063548361.1"
                     /transl_table=11
                     /translation="MTTVMTLDIATEIENAEIDMLSSRLEGLQAMSGNPMQVQMKNFGS
                     ATAFSSKIIAGPAFNTVKGITNADAIDAIISYYKSLQIPCRFEITPAQGTTELFQYLSQ
                     KGFYQSSFHTALYSIPRKGSSLLPSNITLRKLKENEFDIFADIYVRGFNMPSFTKDGVH
                     QNNEILYNEPGWHFFIAEIQNSPAGIGVLYINKGVASLAASATLPEFQRKGCHTALIQK
                     RIKTAIESNCTLIVGQARFGSGSQNNMERAHMKIAYTKSIWTAKDI"
     gene            4597..4800
                     /locus_tag="CE086_RS26140"
     CDS             4597..4800
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000810191.1"
                     /locus_tag="CE086_RS26140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_063549354.1"
                     /transl_table=11
                     /translation="MKQKVVQTCSNCGSHNIGEGEFVGYAQIRKKETMFTSSPVDAYIC
                     TDCGSILLLKVRNYQKFKQKPL"
     gene            complement(5514..6122)
                     /locus_tag="CE086_RS26145"
     CDS             complement(5514..6122)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128205.1"
                     /locus_tag="CE086_RS26145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_023522756.1"
                     /transl_table=11
                     /translation="MSIHTLLVDDHLLVMLGIQRLLESEEDIKVINTVNDPSILIKTVA
                     ETRPDVIVTDIRMKQYNGIELTKDLLAKFPDVKVVILSGYDHEEYYNAAFEAGASAYIT
                     KERSAFDLANAIRQSHMGYILFSKNQIMGNNIEALTSAEQRILHLISKDKTNYEISMDL
                     SISKRTVEYHISSIIRKLGVDSRVGAVVKGIKKGLIEGF"
     gene            complement(6094..8235)
                     /locus_tag="CE086_RS26150"
     CDS             complement(6094..8235)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244598.1"
                     /locus_tag="CE086_RS26150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_063548359.1"
                     /transl_table=11
                     /translation="MRNIGFCIPLSILYLLILLTNNYYFHSSNFKESVNSLLISHFYMI
                     SVISLIFFTIGLISFLKKRQSIVAKKFFSLTSVFGIAILTSLLSSYDINIFKAIEVSSI
                     FMLSYLLISFFSNFPVSTKPKYVKIFNLVSFLISTGLTIIYIFFCCFGYMSNNNFSFLF
                     KVLLITNLFLSISICVFLISLHLRENNLKVKSQLYILIFGIILSFLPIVLLNLIPGLLF
                     GESKIPFTYCLPSIIIFPLTISYLLIKQEVIEFEIRISKWLTNSLFYLLNLFLLNLSVE
                     QFIDLSQKEIFILCSLSVLSVVLSVYIYKLILSLFRYFNIKNDAQSGLHKIELFQTLSK
                     EKHAKELAKLIGQLINQMFNINGVSIIWNSNSIYHSLYETGIFQDMDKFELFNQLNQLE
                     QNLLLKEGTTPIHIQFEKYHLICFPILIYQGMQGAIIIGEKNDYTLFKPKEINELEEVV
                     INSANLLLSVNTLNSNKKEIRKAKVKAQNWKQFNYQIIQSLEDERKRLSIFLHDEILQI
                     LILQLNEIRMLQTKRNFSIDILNSMDEQLEDIIYSIRKMCHNLHPIIVEDLGLEASLHT
                     LKREFELNYRILIHIQFNCKLKILSKNLEIQIYRIIKELLNNAIKHSKGNNVQIHIIEE
                     KGCYVCTVEDDGIGFCVPNSFSEFSTSNHLGLMTIQRQVSELNGNLRISSEKEHGTLVT
                     FTIPVNWEEKNEYTYTTSG"
     gene            complement(8228..9196)
                     /locus_tag="CE086_RS26155"
     CDS             complement(8228..9196)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129906.1"
                     /locus_tag="CE086_RS26155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class 1 isoprenoid biosynthesis enzyme"
                     /protein_id="WP_063548357.1"
                     /transl_table=11
                     /translation="MMVEISGFRDCLINHIAYHISYRNQSDESEILLFIQKCLSQKGKV
                     LNPESSGFSWGELYLALSFLTKRQPITKRELDKAMGIEFIFLSADIIDDLCDGDILNPL
                     YFKNEYPRFLLVSQYLLMQGLIYLTYKTKDTATGDLLQQLIHSCCGEWKDIQFCFSIDK
                     KIILSEEEYMKLIEKKSGLLTETIFRTINPENRILKEITSYIGIAGQLRNDANDAMTDN
                     KNDLQELKAYLPFLKAYEYSYITQDDFFKNLTDKQISSSPEVRALVRDYIEQSGALHYC
                     RILSRLYYRKAFALLEKNFILSTDEMTYFQMMVIGRDHFYA"
     gene            complement(9171..9344)
                     /locus_tag="CE086_RS29550"
     CDS             complement(9171..9344)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030236.1"
                     /locus_tag="CE086_RS29550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_023522753.1"
                     /transl_table=11
                     /translation="MNKALWEFLMEMKKNKLTFENYELCPSLETLSVEERIVLDEYAKD
                     FRVKNDGGNQWV"
     gene            9585..9725
                     /locus_tag="CE086_RS26160"
     CDS             9585..9725
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000606628.1"
                     /locus_tag="CE086_RS26160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_023522751.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.8e-20, bitscore:
                     63.9, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 5.6e-10, bitscore:
                     31.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINEKNLFDLDVQVTTATGDVDPQITSISACTPGCGNTGSFNSFC
                     C"
     CDS_motif       9585..9656
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MINEKNLFDLDVQVTTATGDVDPQ"
                     /locus_tag="CE086_RS26160_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9657..9725
                     /prepeptide="core"
                     /locus_tag="CE086_RS26160_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="11.60"
                     /molecular_weight="1998.3"
                     /monoisotopic_mass="1996.9"
                     /core_sequence="ITSISACTPGCGNTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MINEKNLFDLDVQVTTATGDVDPQ"
                     /leader_location="[9584:9656](+)"
                     /alternative_weights="2016.3"
                     /alternative_weights="2034.3"
                     /alternative_weights="2052.3"
     gene            9775..9915
                     /locus_tag="CE086_RS26165"
     CDS             9775..9915
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000606628.1"
                     /locus_tag="CE086_RS26165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_023522751.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.8e-20, bitscore:
                     63.9, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 5.6e-10, bitscore:
                     31.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINEKNLFDLDVQVTTATGDVDPQITSISACTPGCGNTGSFNSFC
                     C"
     CDS_motif       9775..9846
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MINEKNLFDLDVQVTTATGDVDPQ"
                     /locus_tag="CE086_RS26165_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9847..9915
                     /prepeptide="core"
                     /locus_tag="CE086_RS26165_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="11.60"
                     /molecular_weight="1998.3"
                     /monoisotopic_mass="1996.9"
                     /core_sequence="ITSISACTPGCGNTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MINEKNLFDLDVQVTTATGDVDPQ"
                     /leader_location="[9774:9846](+)"
                     /alternative_weights="2016.3"
                     /alternative_weights="2034.3"
                     /alternative_weights="2052.3"
     gene            10001..13216
                     /locus_tag="CE086_RS26170"
     CDS             10001..13216
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128200.1"
                     /locus_tag="CE086_RS26170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_161520478.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.3e-176,
                     bitscore: 577.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.6e-26,
                     bitscore: 83.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.8e-42, bitscore:
                     136.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISEKRKPIHTSNKTACNNIFEPLPFFMIRSPFLPFNALYQIKNQ
                     EVLIKKLREYAEMDYIKEAIAIASPSLLESLKHIHGDLSSRKTQQVISSVLRYMLRMTT
                     RPTPFGAFSGVASGEFKEKSLLEMSHFEQFKKRTRPDMEWLLGVVSSLEKNPSILQSLM
                     VSKNHAAYRVGNRLYLPFSTECGQLRKKDMEKKENISILYSEVVRKVLDLAETHIKVKE
                     LLQKLQNDYPGTEVKVMENFILQLVEQEYLITELRPPLTYDSPFDYVIDKLKIRVGENQ
                     IWEDLLKVKDLILVYDQLPLGKGLSVYNNLILLMKRIYEVTTPLQVDFALNTQDLAIGK
                     NVANDVSKAAQVLWSIADSGVGFPHLQKYHIDFLEKYGTTREVPLVELLSEELGLGAPA
                     TYKNPKGNRDGENFTLPLDEERNVQLSYMLIEAIHNQQKEIEITDEIISRIGIEKDTRY
                     APDSFEVYGELYATSQEELDNGKYTLCLSPNPGSHAAGSTFGRFLDILDPNVRRKIQQQ
                     EVEIDHQFNNDIVMVEGSFLPATGRSANVAIGKTTREVTVTLGTNGDDDTLQIPIDDIV
                     VGASLENFYLKSKKLGKRIKVVAGNVLNYQSGPNIYRFMREVSLNDLDHWRIFNWGNMT
                     SSPYYPRIRYKNIILSPAIWKLNRETIGMKNKPKSDDEFLILFEKWREKWTVPRHVYMT
                     YSDNRILIDLENILHLRELKNELFKQGRLQLRESLQDINKNCLSSPFGSHAMEVVFPLK
                     KMNDVAKRKSIGAVEDGKKEMVSEKMIYRLPGSEWLYVKLYVPQARENEFISKYMTSFS
                     NYIVQSGMAQSWFFMRYRDPDAHIRLRFYGDPEKLNASVLTYLRDWANNLMDSGFIHKM
                     TVDTYEREVERYGGPYLIELAENFFHYDSRSVTMLLNVIGQQAELPVHVLASLNIIEIM
                     DNFGLTYEQQLETIESNTDKYEFIDEFRPMRKLLSNIGNSEGDWSNLRNYNSAIGQEIY
                     KSLLVRRESLKEYVSSIQQYKNEDMLWNKQQTIMGAIIHMHCNRLLGANRELEKKALAF
                     TRHILSSQRYWRNQNETDTQSRT"
     aSDomain        10487..10777
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CE086_RS26170_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.60E-26"
                     /identifier="RREFam001.1"
                     /label="CE086_RS26170"
                     /locus_tag="CE086_RS26170"
                     /protein_end="259"
                     /protein_start="162"
                     /score="83.1"
                     /tool="antismash"
                     /translation="MVSKNHAAYRVGNRLYLPFSTECGQLRKKDMEKKENISILYSEVV
                     RKVLDLAETHIKVKELLQKLQNDYPGTEVKVMENFILQLVEQEYLITELRPP"
     gene            13188..15071
                     /locus_tag="CE086_RS26175"
     CDS             13188..15071
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129903.1"
                     /locus_tag="CE086_RS26175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_063548353.1"
                     /transl_table=11
                     /translation="MKQILNHVPEDEKLSFINILKSFHYWPGLFKLLWETHRGYFFCVL
                     TLNFLNGLLPAALILTIQYLVNTVQNIYQNGYQDAYFTHVLPFFIAFALVTILTGVTGS
                     VLETYKQLYRNLLSNKINVKLIEKAKRLPYSSFENPEIYNKLQRARQDSTYKPFAIFEE
                     LMGIIKSGITVISISGILMIWNWQFTLILILLPLISSWSIMKIGKEIFLISHKRAEETR
                     KQFYYYYLLTTDITVKEVKLFGLGNLLLKNYSNIFNLFYQQDRHLLLKKMRIDLFFQLI
                     SVAFVMFVQFMVVMDAVTGIIAIGSLIAYFQAVNTTQKTSNELMYMIFNMHQNNLYMTQ
                     LFSFLDIPEERDVSNNRDNTYIESISFEEKGIRFINVSFKYPGQKEYILKKVNFHIKPG
                     ETLALVGSNGSGKSTIVKLITKLYTDFEGIILLDGKSIHQYSTNEWQDKVSAIFQDFVR
                     YELDVKDNIGYGDYKKADQVMAIQAAAKKSGALKMINNLPNKMDTQLGKTFANGIQLSG
                     GQWQRIAISRAYMRDAGLYILDEPTAALDPEAEEEVFRDFKEITKNCMGLFISHRYSTV
                     RHATKIMVLDKGRVAELGTHNELLKVKGIYARLFELQAKNFINHSKIQVKV"
     gene            15089..16444
                     /locus_tag="CE086_RS26180"
     CDS             15089..16444
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001177658.1"
                     /locus_tag="CE086_RS26180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_023522748.1"
                     /sec_met_domain="LANC_like (E-value: 3.5e-72, bitscore:
                     235.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLTTEKKSFWLQGISIEKRNKALKLVRDIAERLKDPMYVEKIVM
                     EPDNIPNGGTLHPWDPITLSHGYPGTIMLFAELDRQFPEEGWDLIAHSHLIEIQKAIEK
                     QGVNSISMFGGVSGIAYATSYASRNYERYHIFLKKLNEFVLSQLHLVLNYQKEECGVHP
                     FMYDTIQGATGVGRYLLQNIQLESNSEALKKILNCFINMSNDIEVNGEVVPGWYVPYAN
                     QFLETDKILFPDGNFNCGHAHGMPGPLSLMALAIEQGIEVPGQKQAIRKMIDWLIRWQD
                     EGSWPARLSFKEVVNDQAYHVYPKRKGWCYGNPGVARALYLAGRSLKDQKSMKIALSSY
                     QDTLLQSEEEWDLASPTFCHGRAGLLQMSIRMAKDENGEISMQSIIKLIDYVMDAYDPQ
                     APFGFKDLQSNEQTSNELNKVGLLEGVSGVLLTLLSLSAVEEPWWDGVFLIS"
     gene            16470..17078
                     /locus_tag="CE086_RS26185"
     CDS             16470..17078
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128197.1"
                     /locus_tag="CE086_RS26185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavoprotein"
                     /protein_id="WP_023522747.1"
                     /sec_met_domain="Flavoprotein (E-value: 2.8e-35, bitscore:
                     113.3, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQMKQLLSSKKILVGVSGSIAVAGIFQYLAILKANFSEVKVIMT
                     KSAIKLIPAETVKLYCNEVFVDEELTLSGKPGHVELARWADLLMVLPATGNTISKVAHG
                     LADDLLSTVILAHDKPVLFFPNMNKLMWEKKVVQNNVSLLGEYDHIVIPPLKTTAFEIA
                     TMSLKPNYVLPNNQEVLHILFKEFEKRKSVTVHETVEMH"
     gene            17175..17909
                     /locus_tag="CE086_RS26190"
     CDS             17175..17909
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058380.1"
                     /locus_tag="CE086_RS26190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_063548351.1"
                     /transl_table=11
                     /translation="MNNEIVLEANHLTKTVGGKTIVNDFSTKIYKGDICGFLGPNGAGK
                     TTVMRMFTGLIRPTKGAIKISGQDVNQNRQQALMNMGAIIESPIFFPYMTGRKMLQNLA
                     RLYPALSRKEQLEQVEAILSIVRLTEDADVKIKNYSLGMRQRLGIAQALLGDPDVILLD
                     EPANGLDPMGMRELRELILELREKKNLTFFISSHLLDEIQQMCDRLVIIRNGKLITQGR
                     KDELITDPTKRLEDVFVEMMTS"
     gene            17906..18736
                     /locus_tag="CE086_RS26195"
     CDS             17906..18736
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161130.1"
                     /locus_tag="CE086_RS26195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_063548349.1"
                     /transl_table=11
                     /translation="MRGLFISEFERLWTQKITWLILLFLPLMVVASVKYYLNWNQHTSP
                     GRPDYVTALNFPIISISEHLVVSFNIIAIILISTVIAYEVENGQLRMILIRPFSTSQLF
                     VAKLATILTTMFLYLTLFWIFNSIAGYLFFPKVDTLITFIDETKVSIAGAILYNLKYFF
                     ACFITMVCIVSVFTLIGALSRSTMITLGSGVAFIFFAIAIPQILEFSNQTIISANTVLH
                     LMYMSIVKIQHTGIAFILSTSNSINIYIVIVEAIYIFLFGMFAYLSFVKRDYFI"
     gene            18756..19514
                     /locus_tag="CE086_RS26200"
     CDS             18756..19514
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000646187.1"
                     /locus_tag="CE086_RS26200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_161520479.1"
                     /transl_table=11
                     /translation="MKALVISEWERLWNQKKSKWMLGIFTVIVFLQAWFLKYYGVGIYN
                     DGQQVPLNSWNFSWFLLKESSFLITLIFMPVCFLNSLNVEYNSGAYRLFLIRPFQRITF
                     LMSKWFSLSIIVLLYLFVVLFVGIVLGLVFFKADDAFMFYGQQKTAIEAILYTVQVYGL
                     FFIIQMCGLALASLISVIISNAVISFFLLIGIYIGCLYISQLSFFLLSVQSIFHALSTG
                     SNTLYVLILGIMIISVSVCISIWNKKEFTC"
     gene            19541..20320
                     /locus_tag="CE086_RS26205"
     CDS             19541..20320
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128192.1"
                     /locus_tag="CE086_RS26205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023522743.1"
                     /transl_table=11
                     /translation="MIMLEAKGIEKVYKTKFREYPVLNNVNLTVHEGDFVGIMGPSGSG
                     KSTLLNVLSSLDFPSNGDITIKGQNLTNMDGDQLSNYRRENIGFIFQNYNLLDHLTIEE
                     NILLPAALRMGSKKGVRDKLNTLGNELNIESLLPKYPYEISGGQQQRAAIIRSLINDPY
                     LLFADEPTGNLDSKSAYDVLNILKTLNETHKTTILMVTHDSVAASFCNRVIFLKDGKIV
                     HEMQRSYEEKQFSFNQRILLYISKEVGENDVNIFTRT"
     misc_feature    19568..19579
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.12"
                     /tool="antismash"
     gene            20295..22142
                     /locus_tag="CE086_RS26210"
     CDS             20295..22142
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128190.1"
                     /locus_tag="CE086_RS26210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_063548347.1"
                     /transl_table=11
                     /translation="MSIFSLALKNITRNFSLYIVYLVSSILSVTIFYMYAAFLSYPKVS
                     GIEQLLIACEFIILLFSCFFISYSYDHFLTERKKEIGIWKTFGASKKQLFIIIVLENTI
                     IGAISIVIGIILGIALSKSFFEFIGKSLFLSESFSYFFSPIATFFTVILFGVLFFFVSL
                     RSYYKIGRISVLELFQETKKTKDLPRFSKKKFIISLLILVISYVFILYATLPVLLFSFL
                     PLSALLLLGTYLFCSHGLVGTVSYLINKEKKHLNGIRMLIFISLRKKLYYNAKIIFLVS
                     IFLSMIMILISSIYLYSELNDQRMRSSHPQPAVFIVDKKQENTLESDLEKNFKGEVEGF
                     HKKKWEGVLLKSSKEEGQTLILQTNSFFIKNWTKTKKDNLLFSKKNANIDKLNIQTNKG
                     NTKLIVKNVVEGHAINPVSGIDNVVFVPADILNELEKGILPTQHVSFYTLDFKEDNKSY
                     SALKTLFEALPLEIKEQSSVRLLHYENTVQLTSVLWIIALFIGFILLIALSSLLWFKLY
                     EDISNDRKIFHALRKIGLNFNEIKKTLRVQIAIIFFVPIILGGINLFIAIYALQNILGG
                     FKIYSIILIFFIFLVFQLVFCFISNHVYYKKVVHEKNIN"
     gene            22204..22884
                     /locus_tag="CE086_RS26215"
     CDS             22204..22884
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001014563.1"
                     /locus_tag="CE086_RS26215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_023522741.1"
                     /transl_table=11
                     /translation="MNGTILVVDDESEIVDVLSDIFCDRGYKVLKAYNGEQALNHLKTQ
                     VDLVILDIMMPKMDGFEFCKVVREQIKCPILFLSAKHSEIDKVKGFTLGGDDYITKPFQ
                     VKELIARVEAHLRREKRERVNLQNQRFLGNLTINYLQHDVFIDGVKIDVTSKEFKILEL
                     LTVNLGQIFSKEQIYEKIWGLDAVGDLNTIIVHINNLRAKLSLGMSTYHIKTVWGVGYK
                     LEKC"
     gene            22884..24338
                     /locus_tag="CE086_RS26220"
     CDS             22884..24338
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002185398.1"
                     /locus_tag="CE086_RS26220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_043924693.1"
                     /transl_table=11
                     /translation="MLKKLSLKNQFILTFAAVIFLSIVSTVCTLILIYSFLFIYNEKSV
                     LPANHYEKQVPSIEKFVEMNGDKIVDLSYQKKIEKVIPMQGITYQVMNTNGNRLYGTLS
                     DELLKNDKEVYHKINTSTQNGKLITKYIPIMSNDQLVGVLAVRYILAASIDYYIEYVFI
                     IAFLIPFIFLTLYSYLLAKRLGKQLNKPIKEVIMASQKIKNKDLDFEIKYESENEIGIL
                     IDSFNSMKEELKNSLYVQWKLEQERRDMVASIAHDLRTPLTIILSHVEVLMEPMPNNQK
                     RLHHYLQTIKNNTERVLHLTEEMRRISEVDNPDFTLMICNIAPAEMIPEMLEEFKELAK
                     NEDIQLTYTLLIKPEEKNLKFALDPNRLHQILTNIISNSIRFTPKKGRINVQVEVKKDV
                     MSFSISDSGVGFNTKDIPFLFSKFYQGDLSRSNQLHHGLGLYIVEKLVEKHGGEIHAEN
                     NEIQGARISFTIHALFSNKKRNYELS"
     gene            complement(24350..25765)
                     /locus_tag="CE086_RS26225"
     CDS             complement(24350..25765)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127292.1"
                     /locus_tag="CE086_RS26225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_065484953.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 8.7e-47, bitscore:
                     151.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQAITVIATVLTYFLFSNVGHAQEKPKQYYTVLLKDPSKLDQG
                     ITEIKKKDGEITYTVPEIGLIQFKGDTQVSTNQSPLFESVNPSLQVETPEISHSIKIPN
                     LSNFSTKTLDTNLPPLWDMQWDMKELTHNGESYKKETGSHNVVVGIIDSGVDVDHPDLV
                     KNLIPGSKNFVPKGGLRGTEPEETGDINNINDINGHGTLVTGSIAANGEIKGVAPNTGI
                     RAYRVFGNKSADAAWVINAIIEAAKDDVDVINLSLGSYYVNGKVYENGKLVDNGWAEVE
                     GYKRAIEYANQRGSIVVASAGNDSINVANKQELNNFLKQKYEKEGKTYTGVGIEAPGEL
                     PGVVTVSSTGPTGQRSVFSNYGEGFIDISAPGGDYRLWQQYGEEVWWNTGLFRQEEVLT
                     TFNTGRYLFAAGTSMAVPKVSATLALIINHYNYKNQPNRSISHLYKNGIKKDIAPDKAS
                     WGYGQLDVYNAIK"
     misc_feature    26067..26078
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.05"
                     /tool="antismash"
ORIGIN
        1 gatgcgtaca tttctgttaa tgaacgatct tgtatatggt ttcgcaaacg tctagaaatg
       61 ttcggatgac gttttttttg agttggtgaa tattttttac gactcataat agttcctccg
      121 tacaaatagc atctaaaaag atttgtctat ttataactat aatatagatg taatgtgtat
      181 ttctataaaa aatggaagtt atagaataaa ttttgttttt ttttattttt tgcaaggtga
      241 atgcaggatg gtaataaggg gagcttatat tgttttataa accttttgta agttacagac
      301 ggccgttttc cgtataacat tagggtagag gagggggaga gaaaatgaaa aattatattc
      361 aagggattga tcacgtgcaa gtagctgcac ctgtagggtg tgaagaagag gcgcgtgatt
      421 tttatgggaa tacgattggt atggaagaaa ttccaaagcc agaagagttg aaaaaacgag
      481 gtggatgttg gtttaaatgt ggaaatcaag aaatccatat tggtgtcgag cggaacttta
      541 caccagctaa aaaggctcat ccagcttttt atgtgaatga aattaatgaa tttaagcaaa
      601 cacttataga gcaaggtgtt aaagtgattg atgattatgc acgaccagat gtaattcgat
      661 tttacgtgtc agatccattt ggaaaccgaa ttgaatttat gcaaaataaa gactaggtgg
      721 attcccacct agtctttaac ttcttctgaa aagtcctaac acttctacag tttctgtaat
      781 attaacgaat gcattcggat cgatttcaga aattgttagt ttcatacttg ctaattcttc
      841 acgagaaacg accgtcataa gtacacgctt tttctcgctt gaataagcac cttcgccatc
      901 aagtaacgtt attccacgta caacagttga aagaagttgt tttttcattt tttctgcttc
      961 atttgttaca atcataagtg taactttacg atgttttgta tgaacagcat caattacttt
     1021 accagttaca taaattgaaa gtaagcttgt aagtgcaaca tcccaggtga agaaaaatcc
     1081 tgcgattatt acaacgactg catttaaaat aataaggaat ccgccaagtt taatgtctcg
     1141 cttgcgggat aaaagcatac cgataatatc aaatccacca gtggatccat tacagttaaa
     1201 aacaagacca ataccagctc cggcgatgac acctccgaag atagaagata acaatggatc
     1261 tgttgctacg acttttactg gaacgtagta taatgcaaca gataatacaa ctacagagac
     1321 aactgtgtta aaaattactt tttttccaag acctatgtac cctaaaataa ggataggtaa
     1381 gtttaataca aagttaataa tgcctgtgtt tacaggggtt acaatcccta aaataatagc
     1441 aattccgcca attccactac ttaaaatttt gtgggggata aggaaaagat taaaggcaac
     1501 cgcaataata atagaaccga taataacacc aaggaatctg accatttctt tcccgtcctt
     1561 cactgaaaaa ttcatattat ttcaagatta tatatgatat tgaaagtttt gggtaaaaac
     1621 agtttattta ggtaaattag attaatcaaa agaatttgag tattttatca tttgaaaggg
     1681 gatacagttg tgaagataaa aacatatcaa cagaaaagcc cgttgaagca agaatgtgag
     1741 gattcttatt tttgtaataa agaaaaaaag atttatggtg tatgtgacgg tgcaacacca
     1801 cttgtcccgt ttcgtgatga aaagggacat aatggagcat acatcgcttc gcatttattt
     1861 gcaagttatt ttactgcatt acgagagaat catagtttac aatttgcagt tgccaaagca
     1921 aatgaagcat tgcaaagcaa aatgttagaa tatgaagtag acacgagaaa aaaagagcat
     1981 ttgtggtgca catgtatcgc ggcagtccaa atagttggtg agaaaattga atatgcgcag
     2041 cttggggact gtatgattgt cgcaactttt caaaatggaa cgatgcaagt attaacgaaa
     2101 gacacagttg aaggaattag taaaagagca aaaaagaaga gggaagaaga tcgtaaaaaa
     2161 gggttatctg taccagaaga atatgttttt caagatgttc gagaacagtt aaaatacaat
     2221 cgttatcttg caaatatgcc agatggttat tcagttgcaa atggaatgaa agaagcgata
     2281 cattatttac aacatggtga attacataca gatgaagtga gtgggatttt tatttgttca
     2341 gacgggttat ttcacccaga ttggtcatta gaacaaactg ttgcatatat aagaaagaat
     2401 agtataaacg aatatatagc aattattgaa gagctagaag cggaaaagag aataaggcca
     2461 gatgataaaa cgattattat gattgatttt taagaggagg cagttcaaat ggaaattaaa
     2521 cgtgtcaatc taacatttca agatgaatta gttcctttag aaaaagtaaa caaactgatt
     2581 attcaccata cagctgaaga tggatgggac gtgtataaaa cgcatgaatt tcatcaaact
     2641 gtaagggggt ggagcggaat tggttacaac tattttatcg aaaaggatgg aactgtagtg
     2701 gaaggacgag gtttacatat tggagcgcac gcgaaagacc ataaccgcca tacaattgga
     2761 atatgtatga cgggaaattt cgataaatac gatccaactc ctgcacaagt gaatgcatta
     2821 tattctttat gcaaactgtt tatgaagcaa tttgctataa agaaagaaaa tatactcggt
     2881 catagagagt tagaaggagt tacaaaaagc tgtcctggta atcgtttttc tatggtagag
     2941 ttaaggaaga tactatctta aatatagagg agtaacaacg atgatgaata taaaaatacc
     3001 aaatgataaa aaagaagaac ttgtagcaca aattcagcaa ttttttatgg aagaagattt
     3061 agatgaaatt ggacgtttcc aagcagagcg tttaatagaa gaaatgatta aattagttgg
     3121 accgtttgca tataatcaag caattggaga tgcaagaaag cttgtaagtg agaaattaac
     3181 gaatatcgaa gaagatttat acgtgctaga gaagaatgaa ggaaaataaa aaaagagccg
     3241 atgggctctt tttttatttt tctttcttat gttctttata ttcatgtact ttttctttta
     3301 cattaccaac tgtatcttta gcagtgcctt tcaccttatc ccattttcct tcagcttgta
     3361 atttcttatt gtcagttact ttcccaacaa cttcttttac ttcacctttt accttatcaa
     3421 tggcaccttc tactttttct tttaaaccat gatcatgttt agtcatacat ttctcctcct
     3481 tgtagtttga ttagaattct cttttcatat tgcaagttga atgatgtatc tagtaatatc
     3541 gtaacaaatc tagtttgaat attcaaatga ttaataggat agaaaaggat ttgtcataaa
     3601 atgtttaaaa atgtaacgga aggagaaata aagtaaatta tatgtctttt gcggtccata
     3661 ttgattttgt ataagcaatt ttcatgtggg cacgctccat gttattttga ctgccgctac
     3721 cgaaccttgc ttgtccaact attaaagtac aattggattc aatagctgtc ttaattcgct
     3781 tttgaattaa tgcagtatga cagcctttac gctgaaattc tggcaaagta gcagaagcag
     3841 ctaatgatgc gacaccttta tttatataca ggacaccaat accagcaggg ctattttgaa
     3901 tttctgctat gaaaaaatgc catcctggtt cattgtaaag aatttcgtta ttttggtgaa
     3961 caccatcttt tgtaaaggat ggcatattaa atccacgtac atatatgtct gcaaaaatat
     4021 caaattcatt ttctttcagt tttcgtaatg taatattaga aggaagaagt gatgaaccct
     4081 ttctcggtat actatacaaa gcagtatgga agctagattg gtaaaaacct ttttgagata
     4141 agtattgaaa tagttcagtt gtgccttgcg ctggtgtaat ttcaaaacgg caaggaattt
     4201 gtagtgattt ataataagaa atgattgcat caatcgcatc tgcatttgta atacctttta
     4261 ccgtattaaa agcaggaccg gcaattattt ttgatgaaaa ggcagtggca ctaccgaaat
     4321 ttttcatttg cacttgcatt ggatttccac tcattgcttg tagtccctct aatctagaag
     4381 agagcatatc aatttctgca ttttcaattt ctgttgctat atcgagtgtc ataacagtag
     4441 tcataaaatt cctccgttaa taaatatatt tcatagtata tatacgattt ttgttttgag
     4501 attcctgttg taatgtagga gaataagaag ttttttggaa gggaaatgga attgaactgt
     4561 cgaagggagt ggaaacagat taaaggtggt gctctcatga aacaaaaagt cgtgcagaca
     4621 tgctctaatt gtggttctca taacatagga gaaggtgagt ttgtcggata tgcacaaata
     4681 cggaaaaagg agacgatgtt cacatcttca ccagtagatg cttatatttg tacagattgt
     4741 ggcagtatac ttctgttaaa ggtacggaac tatcaaaagt ttaagcagaa accgttatga
     4801 tgattaaaag atgattatac cccaacttgt ttacgaatcg tcttatatta aggaaattga
     4861 tataagtgat attttacata tatgtgaata tgatataggg aaataattgg taatttatat
     4921 cgcataaggg tacataaatc gctgagtgat acgaaaaata aagaagattt ataaaaatgt
     4981 tacgctattt ttcccttaga taatttttgt ctaagggtct ctctcttcta acgaaagtac
     5041 agtttagtaa agctattatt aagaggaact gttatcggca ttgttatact ctagtattag
     5101 gaaaaaatgt acgctatgaa gtcaaaatat aaggtggaca ggtgaataat ataaaacctc
     5161 ctaaataaca tcagtgtaat cataacttga taaagtatat agaaatagga acggtgttta
     5221 catacagttt agttatcaaa acaaaggagg catatttata tggaggttgt gagaagcttt
     5281 taagtttccg atgtatgcgt aacagttaat gtaagaaagg attttatttt tggggtttta
     5341 aaaaatatca ataaatgatt aggataacag ttgtttaaaa tgaagaaata ggccttcatc
     5401 actgggacct atttcttcat tttatggctc tggtagtaat gagctatact tccgcattac
     5461 cttatctttc aagagacttt gtaatggaac tgttttgcaa tgtccttttg taattaaaaa
     5521 ccctcaatta atcctttttt aatccctttt acgactgctc caactcttga atctacaccc
     5581 aattttctaa taattgaaga aatgtgatat tctacagttc ttttgctgat ggaaaggtcc
     5641 atactaatct cataatttgt tttatctttt gagattaagt gaagtattct ttgttcagca
     5701 gaagttagtg cttcaatatt atttcccata atttgatttt tagaaaatag tatatatccc
     5761 atgtgacttt gacgaatggc gttagctagg tcaaatgctg atctttcttt cgtgatgtat
     5821 gcacttgctc cagcttcaaa ggccgcatta taatattctt catgatcata tcctgataga
     5881 attacaacct ttacatccgg aaattttgcc aataaatctt ttgtaagttc aatgccgtta
     5941 tattgcttca tcctgatgtc cgtaacaatt acatcaggac gggtttctgc cacggtttta
     6001 attaatatgg aaggatcatt gacggtatta attaccttaa tatcttcctc agattctagt
     6061 agtctttgga tgcctagcat aactagcaaa tggtcatcca ctagtagtgt atgtatactc
     6121 atttttttcc tcccaattta ctggaatggt aaatgtgact aatgtcccat gttctttttc
     6181 agaagatatt ctcaaatttc cgtttaactc ggaaacttga cgctggatag tcattaggcc
     6241 aaggtggttg cttgtactaa attcagaaaa actgtttgga acacaaaagc ctatgccatc
     6301 atcttctaca gtacaaacat agcagccttt ttcttctatg atatgtattt gaacattatt
     6361 ccccttggaa tgcttaatag cattattcag tagctctttt attatgcgat agatctgtat
     6421 ttcgagattc ttcgagagaa tttttaattt gcaattaaat tgtatatgaa tgagaatgcg
     6481 ataatttaat tcgaactcgc gttttagtgt gtgtaaactc gcttctaagc ctaaatcttc
     6541 tacgataata gggtgaagat tatgacacat ttttctaata ctatagataa tatcttcaag
     6601 ttgctcatcc attgaattta atatatctat agaaaagttt ctcttagtct gaagcattct
     6661 tatttcgttt aattgcaaaa taagaatttg aagaatttca tcatgtaaga aaatcgaaag
     6721 ccttttcctt tcgtcctcta gagactgtat aatttggtag ttaaattgtt tccagttttg
     6781 agcctttacc tttgcttttc gaatttcttt tttattacta ttgagggtat taacacttaa
     6841 tagtaaattt gccgagttta ttacaacctc ttcaagttca ttaatttctt taggtttaaa
     6901 taatgtataa tcattttttt caccaataat aatagctccc tgcatgcctt ggtaaataag
     6961 tattggaaaa caaattaagt ggtatttttc aaactgaata tgaataggag tagtaccttc
     7021 ctttagtaac agattctgtt caagttgatt caattggtta aatagctcaa atttatccat
     7081 atcctgaaaa atacctgtct catataatga atgataaata ctatttgagt tccatattat
     7141 agacacacca ttaatgttga acatctggtt aataagctgt cctattaatt ttgcaagctc
     7201 tttagcatgt ttctccttag agagtgtttg aaaaagttca atcttatgta aacctgattg
     7261 cgcatcattt tttatgttga aatacctaaa taatgagaga ataagtttat atatatatac
     7321 agagagtaca acagataata cacttaagct gcatagtatg aatatttctt tttgtgacaa
     7381 atctatgaat tgttcaaccg ataaatttaa aaggaataaa ttgagcaagt aaaagagtga
     7441 gtttgttagc catttagaaa ttctaatctc aaattcaata acttcttgct ttattaataa
     7501 ataagaaata gttaaaggaa atataataat actaggtaaa caatatgtaa atggaatttt
     7561 agattcccca aaaagtagac caggaatcag attaagtaga acaattggta aaaaactaag
     7621 gataatacca aaaattagaa tatataattg acttttcacc ttaagattat tttctcgtaa
     7681 atgtaatgaa ataagaaaaa cacagatgct aatactgaga aataggttag tgattagtaa
     7741 aactttaaat aaaaagctaa aattattgtt agacatatat ccaaaacaac aaaaaaatat
     7801 ataaataata gtcaatcctg ttgaaattaa aaatgataca aggttgaata ttttcacata
     7861 ttttggtttg gtagatacag ggaaattaga gaaaaaactt attaatagat aagaaagcat
     7921 aaaaatgcta ctcacctcta tagctttaaa aatatttata tcatagctag ataataaaga
     7981 tgttagaatg gctatcccaa agacagatgt tagagaaaag aatttttttg ctacaataga
     8041 ttgtcttttt tttaaaaagc taattaaccc tatagtgaaa aaaataagac taataacgct
     8101 gatcatataa aaatgactaa ttaataaaga gttaacactt tctttaaaat tactagagtg
     8161 aaaatagtag ttattcgtta aaagtattag taaatataaa atgcttaaag gaatacagaa
     8221 cccaatatta cgcatagaag tgatccctgc ctataaccat catttgaaaa taagtcattt
     8281 cgtctgtaga aagaataaaa ttcttttcta agagtgcaaa tgcttttcta taatatagcc
     8341 gagataggat acgacaatag tgaagtgctc cagattgttc tatgtaatcc cgaaccaatg
     8401 ctcgtacttc aggtgaagaa gaaatttgtt tgtctgttaa atttttaaaa aaatcatctt
     8461 gtgttatgta actatattca taagctttta aaaaaggaag ataagccttt aattcctgaa
     8521 ggtcattttt attatctgtc atggcatcat tagcatcatt tcttagctgg ccagctatcc
     8581 ctatatatga tgtgatttct tttaaaattc tattttcagg attaatagtt cgaaagatag
     8641 tttctgttag tagacccgat ttcttttcaa taagcttcat atattcttct tcacttaaaa
     8701 ttattttttt atctattgaa aaacaaaatt ggatatcttt ccattcccca caacacgaat
     8761 gtattagttg ttggagaaga tctcctgttg cagtatcttt tgtcttataa gttaagtata
     8821 tcagtccttg cataagtaaa tattgagaaa ctaacaaaaa acggggatat tcatttttaa
     8881 aatataatgg atttaatatg tctccatcac acaaatcatc tattatatcc gctgataaaa
     8941 aaataaattc aatccccatt gccttatcca attctctctt tgttattggt tgtcgtttgg
     9001 tcaaaaaaga aagagctaga tatagctctc cccaagagaa accggaagat tctggattta
     9061 aaacctttcc tttttgggaa agacatttct gaataaatag aagtatttca gattcatcac
     9121 tttgattacg gtaggagata tggtaagcaa tgtgattgat taaacaatct ctaaacccac
     9181 tgatttccac catcattttt cacccggaaa tcctttgcat actcatctaa tacaattcgc
     9241 tcttcaactg atagagtttc caatgaagga cataattcat aattttcaaa ggtaagtttg
     9301 ttttttttca tctccattag aaattcccat agtgctttat tcataaaaac aaccctcttt
     9361 ctaaatattc tgtattttgg ttctatataa aaaaatacaa taaaaacggt atgttttcaa
     9421 tatagtcctt aaattttcaa tacttaattt acatattttt tattttataa tgcgtgaatt
     9481 tacaatataa gcttgcggaa tatacggatt ctactaggat atttatctga taaattagac
     9541 acataagaca taacgtctta aaaaattttt agggggaaaa gaaaatgatt aatgaaaaaa
     9601 acctttttga tttagatgta caagtaacaa cagctacagg cgatgtagat ccacaaatta
     9661 caagtatctc agcttgtacg cctggttgtg gaaacacagg ttcattcaat agcttctgtt
     9721 gctaattgct aaataagaca tattgtctta aaaaaacttt agggggaaaa gaaaatgatt
     9781 aatgaaaaaa acctttttga tttagatgta caagtaacaa cagctacagg cgatgtagat
     9841 ccacaaatta caagtatttc agcttgtacg cctggttgtg gaaacacagg ttcattcaat
     9901 agcttctgtt gctaattgaa tgcccaaaaa gagggaacac agatgtgtcc ctcttttctc
     9961 ctattacaat acttgattag aacagaaagg aagattcaaa atgatttcag aaaaaaggaa
    10021 gcctatccat acatcaaata aaaccgcatg taataatata tttgaacctc taccattttt
    10081 tatgattaga tccccgtttt taccatttaa cgcgttatat caaattaaga atcaagaagt
    10141 attgattaaa aaattaagag aatatgcaga aatggattac attaaggaag ctattgccat
    10201 tgcaagtcct tcattgcttg aatctcttaa acatatacat ggtgatttaa gtagtaggaa
    10261 aacacaacaa gtaatatctt ctgtattaag atatatgtta agaatgacaa cacgcccaac
    10321 accttttgga gctttttctg gggtagcatc cggagagttt aaggaaaaat ctttacttga
    10381 aatgagccat tttgaacaat ttaagaaaag aactcgtcct gatatggaat ggttattggg
    10441 agtggtttca tcacttgaaa aaaatcctag tattctccaa tctttaatgg ttagtaaaaa
    10501 tcatgctgct tatcgtgtcg gaaaccgcct atatttacct ttttcaactg aatgtggaca
    10561 acttcgcaag aaggatatgg agaaaaagga gaatatttca attttgtata gtgaagttgt
    10621 taggaaagtt ctagatttag ctgaaacaca tattaaagtg aaagagcttc tccaaaagtt
    10681 gcaaaatgac tatccaggca cagaagtaaa ggtaatggaa aactttattc tccagttggt
    10741 agaacaagaa taccttataa ctgaactaag accgccactt acatatgact ctccatttga
    10801 ttatgtgatt gacaagttaa aaataagagt tggtgaaaat caaatatggg aagatttact
    10861 gaaggtaaaa gatttaatac ttgtttatga tcaattaccg cttgggaagg ggctttctgt
    10921 ttacaacaat cttatcctat taatgaagag gatttatgaa gttacaacac cccttcaagt
    10981 cgatttcgct ctaaatacgc aagatttagc cattggaaaa aacgtagcaa atgatgttag
    11041 taaagcagct caggtgttat ggagtatagc tgatagtgga gttggattcc ctcatctcca
    11101 aaaatatcat attgattttt tggagaaata tggaactacc agggaagttc cattggtaga
    11161 acttttaagt gaggaattag ggcttggagc acccgcgaca tataaaaacc caaaagggaa
    11221 tagggatgga gaaaatttta cgctgccttt agatgaagaa cgtaatgttc aattatcata
    11281 tatgcttatt gaagctattc ataatcagca aaaagaaatt gaaattacag atgaaataat
    11341 tagcagaatt ggaatagaaa aagatactcg atacgctccg gattcatttg aagtatatgg
    11401 agaattgtat gctacttcgc aagaggaatt agacaatgga aagtacacgc tatgcctaag
    11461 cccaaatcca gggtctcatg cagcaggaag cacatttggt cgatttctag atatcttaga
    11521 tccaaatgtt agacgtaaaa ttcagcaaca agaagtggag attgaccatc aatttaataa
    11581 cgatattgtt atggtagagg gaagttttct tccggcaact ggccgttcag cgaatgtggc
    11641 aattggaaaa actacaagag aagtaacggt aactcttgga acaaatggag atgacgatac
    11701 tttgcaaatt ccaattgatg acattgttgt tggagcatca ttagaaaact tttatctgaa
    11761 atctaaaaaa ttagggaaaa gaattaaagt agtagctggt aatgtattaa attaccaaag
    11821 tggccctaat atttatcgct tcatgagaga agtttctcta aatgatttag accactggag
    11881 aatatttaat tggggtaata tgacatcttc accttattat ccaaggattc gttacaaaaa
    11941 tatcattctt tctcctgcaa tttggaagtt aaatagagag actattggca tgaaaaataa
    12001 acctaaaagt gatgatgaat ttttaatcct atttgaaaaa tggagagaga aatggacggt
    12061 tccacgccat gtatatatga cgtatagcga caacaggatt ttaattgatc ttgaaaatat
    12121 tcttcacctt cgagaattaa agaatgaact ttttaagcag ggtagattac agttgagaga
    12181 gtcattacag gacatcaata aaaattgtct aagcagtccg tttggtagtc atgcaatgga
    12241 agttgttttt ccattgaaaa aaatgaacga tgtcgctaaa agaaaaagta taggagctgt
    12301 tgaagacggg aaaaaagaaa tggttagtga gaaaatgatt taccgtttgc ctggaagtga
    12361 atggctatat gttaagcttt atgttccaca agcaagagag aatgaattta tttcaaaata
    12421 tatgacatca ttttctaatt atattgtgca aagtggtatg gctcaatcat ggttctttat
    12481 gcgatatcgt gatccggatg ctcatattcg tttgcgtttt tatggagatc ccgagaagtt
    12541 gaatgcatct gttcttacct atttaaggga ttgggcaaat aatttaatgg actctggatt
    12601 tatccacaaa atgacggttg atacgtatga acgagaagta gaacggtatg gtggtccgta
    12661 tctgatagaa ttggccgaga atttcttcca ttacgatagt aggtcagtaa caatgcttct
    12721 taatgtgata ggacaacaag cggaactgcc agtacatgta ttagcatcct taaacataat
    12781 tgagatcatg gataattttg gattaactta tgaacaacaa ttggaaacca tagaaagcaa
    12841 tacggataaa tatgaattca ttgatgaatt tagaccaatg agaaaattat taagtaacat
    12901 tggaaattct gaaggtgatt ggagtaattt acgtaattac aattcagcaa ttggacaaga
    12961 aatttataaa agtttattag ttcggagaga atccttaaaa gaatatgttt ccagcattca
    13021 acaatataaa aatgaagaca tgctctggaa taaacaacaa acaattatgg gagcaattat
    13081 tcatatgcat tgtaatcgac tattgggagc taatcgagaa ctagagaaaa aagcacttgc
    13141 ctttacgcgg catatcttat caagccagcg atattggagg aatcagaatg aaacagatac
    13201 tcaatcacgt acctgaagat gagaaactat catttataaa tattctaaag tcttttcatt
    13261 attggcctgg tttatttaaa cttttatggg aaacgcacag agggtatttc ttctgtgtgc
    13321 ttaccttaaa ttttttaaat ggattattac ctgcagcatt gattttgaca atccaatacc
    13381 tcgttaatac agtacagaac atctaccaga atgggtatca ggatgcttat tttacccatg
    13441 ttttaccgtt ttttatagct tttgcactag ttacaatttt aacgggtgtt acaggatccg
    13501 ttttggaaac atataaacag ctttaccgaa atcttctttc taataaaatc aatgtaaaat
    13561 taatagaaaa agcaaaaaga ttaccttatt ccagttttga gaacccagaa atttacaata
    13621 aacttcaaag agcgcgccaa gattccacat ataaaccatt tgccattttt gaagaactta
    13681 tggggattat aaaaagtgga ataactgtga tttctatttc cggtatctta atgatttgga
    13741 attggcagtt taccctaatt ttaattttgt taccactaat ctcttcttgg tccatcatga
    13801 aaattggaaa agaaattttt ttaattagtc ataagcgtgc tgaagaaaca cgaaaacaat
    13861 tttactacta ctatttgcta acaacagaca tcacagtaaa agaagtgaaa ttatttggat
    13921 taggcaattt gcttctcaaa aattattcga atatcttcaa tctattttat cagcaagata
    13981 gacatttgct tttaaaaaag atgaggattg acctgttttt ccaattaatt agtgttgctt
    14041 ttgtaatgtt tgtgcagttt atggtggtta tggatgctgt aacagggatt attgctattg
    14101 gaagtcttat cgcttatttt caagctgtaa atactacaca aaaaacatct aatgaattaa
    14161 tgtatatgat ttttaatatg catcaaaaca atctttatat gactcaacta ttctcatttt
    14221 tggacatccc tgaagaaagg gatgtttcaa ataatagaga caatacttat atagaaagta
    14281 tctcttttga agaaaaaggt attcgattta taaatgtctc ttttaagtat cccggtcaaa
    14341 aagaatatat attaaaaaaa gtgaattttc acataaaacc aggtgaaaca ttggctcttg
    14401 tcggatctaa tggttcgggt aaatctacaa ttgtaaagtt aattacaaaa ctttatacgg
    14461 actttgaagg gattattcta ttagatggaa aatccattca tcaatacagt acaaatgaat
    14521 ggcaggataa ggttagtgcc attttccaag actttgttag atatgaacta gatgttaaag
    14581 ataatattgg ctatggtgat tataaaaaag ccgatcaagt gatggctata caagcggctg
    14641 ctaaaaaatc tggagcatta aagatgatta ataatttgcc taacaaaatg gatacacaac
    14701 ttggtaaaac ttttgcgaac ggaatacagt tatctggagg acaatggcaa agaatcgcca
    14761 tttcacgagc atacatgagg gatgcgggcc tatatattct agatgaacct actgccgcat
    14821 tagatccaga agcagaagaa gaggttttta gagattttaa agaaattaca aagaattgta
    14881 tggggctttt tatatctcat cggtattcaa ctgtaaggca tgctacaaag attatggtcc
    14941 ttgataaagg tagagtcgcg gaactaggta ctcataatga attactaaaa gtaaaaggaa
    15001 tatacgcaag actatttgag ttgcaagcta aaaattttat aaatcattct aaaattcaag
    15061 tgaaggtgta attagagagg agaaaactat gcgattaact acagaaaaaa aatcattttg
    15121 gttacaggga attagtattg aaaaaagaaa taaagcatta aagttagttc gtgatatagc
    15181 agagcgatta aaggatccga tgtatgtaga aaaaattgtt atggagcctg ataatatacc
    15241 aaacggagga acacttcatc catgggaccc cattacttta tcccatggtt atccaggaac
    15301 tattatgtta tttgcagaat tagatcgaca gtttccagaa gagggatggg atcttattgc
    15361 acatagtcac ttgatagaaa tacaaaaggc aatagaaaaa caaggtgtga atagtatttc
    15421 tatgtttggc ggtgtttctg gtattgcgta tgcgacttca tatgcttcgc gtaactatga
    15481 aagatatcat atatttttga aaaagttaaa tgaatttgta ttatcgcagt tacatcttgt
    15541 attgaactat cagaaagaag agtgtggtgt tcatccattt atgtacgata caattcaggg
    15601 cgctactgga gtaggtcgtt atttgttgca aaatattcaa cttgaatcaa attcagaagc
    15661 actcaaaaaa attctcaatt gttttattaa tatgtctaat gacattgaag tgaatggtga
    15721 agttgtacct ggttggtacg taccgtacgc caatcagttt ttggaaactg ataagatact
    15781 atttccggat gggaatttca attgtggcca tgctcatgga atgcctggcc cgctttcctt
    15841 gatggcgttg gctattgaac aaggaattga agtccctggg caaaagcaag cgattcgtaa
    15901 aatgatagat tggttaataa gatggcaaga tgaaggttcg tggcctgcca ggcttagttt
    15961 taaagaagtg gtcaatgacc aagcatacca tgtgtatcca aagcgaaaag gttggtgcta
    16021 tggaaatcca ggagtagcaa gagctctcta tttggctgga agatctttga aggatcagaa
    16081 atccatgaaa atagctttaa gttcttatca agatacactt ttgcaaagtg aggaggaatg
    16141 ggatttagca tctccaacat tttgtcatgg aagagcggga ttattacaaa tgtctattag
    16201 gatggcaaag gatgaaaatg gggagatatc gatgcagtcc attataaaat taatagatta
    16261 tgtaatggat gcatatgatc ctcaagcacc atttggtttt aaagacttac aatccaatga
    16321 gcaaacatcc aatgagttaa acaaggttgg actattggaa ggtgtaagtg gtgtactttt
    16381 aactttatta agtctaagcg cagtagagga gccatggtgg gacggagtat ttttaatttc
    16441 ctaataaaaa attgagagga tgttacagta tggaccaaat gaagcaattg ctcagttcta
    16501 agaaaatatt agtaggagta agcggatcta ttgcagtagc tgggattttt caatatttag
    16561 ctatattgaa agcgaatttt agtgaagtaa aggttatcat gacaaaaagt gcaataaagc
    16621 ttatccctgc agaaactgtg aaattatatt gtaatgaggt atttgttgat gaggaactta
    16681 ctctaagtgg taaaccaggt catgtggaat tggctagatg ggcagactta ctaatggtac
    16741 taccggctac aggaaatact atttcaaaag tagctcatgg tttagctgat gatttattaa
    16801 gtacagtcat tcttgctcat gataaaccag ttctcttttt tcctaatatg aacaaattaa
    16861 tgtgggagaa aaaagtagtt cagaataatg ttagtctttt aggagaatat gatcatatag
    16921 tgattccgcc tttgaaaaca acggcttttg aaattgcgac tatgtctttg aaaccgaact
    16981 atgttttacc taataatcaa gaagtattgc atatactctt taaggaattt gagaaaagaa
    17041 agtcagtaac tgtacatgaa acagttgaaa tgcactaaaa ctcacaaaaa tgtgagtttt
    17101 ttattttttt ctttcttttc tttatttttt ttttatattt gtcttctata ttagtccata
    17161 aggagggatt ttatatgaat aatgaaatag ttttagaagc aaatcactta acaaaaacag
    17221 taggtggtaa gacaatagta aatgattttt caactaaaat atataaagga gatatttgtg
    17281 gttttctggg gccgaatggg gcaggaaaaa caactgttat gcgtatgttt acaggattaa
    17341 ttcgcccgac aaaaggggcc ataaaaataa gtggtcaaga tgtaaatcaa aatagacaac
    17401 aggctttgat gaatatgggg gcaattattg aatcaccaat attcttccca tatatgacgg
    17461 gtagaaaaat gctacaaaat ttagcgagat tataccctgc tctttcgcga aaagaacaat
    17521 tggaacaagt agaagcaata ctatctattg taaggttaac tgaggatgcg gatgtgaaaa
    17581 ttaaaaatta ttcattagga atgagacagc gacttggcat tgcacaagct cttctaggtg
    17641 atcctgatgt tattttgtta gatgagccag caaatggcct ggatcctatg ggcatgagag
    17701 agttaaggga attaattctt gaacttcgtg aaaagaaaaa tttaaccttt tttatttcaa
    17761 gccatttact agatgaaatt cagcaaatgt gtgaccgtct tgtcataatt agaaatggaa
    17821 aacttattac gcaaggaagg aaagatgaat taattacaga tccaacaaaa aggttggaag
    17881 atgtgtttgt ggagatgatg acatcatgag gggacttttt atttctgaat tcgaaaggct
    17941 ttggacgcaa aaaataactt ggttaatctt gcttttctta cctttaatgg tagttgcgtc
    18001 agtgaaatat tacttaaact ggaatcaaca tacttctcct ggaagaccag attacgttac
    18061 tgctttaaat tttcctataa taagtatttc tgagcatctt gtggtttcgt ttaatattat
    18121 cgctataata ctgatttcca ctgttatagc gtatgaagta gaaaatggac aattaagaat
    18181 gattttaatt cgtccattct ctacctcaca attgtttgta gctaaacttg ctactatatt
    18241 aactaccatg tttctatatt taactttgtt ttggattttt aattctatag cgggttattt
    18301 attctttcca aaggtagata cattaataac atttatagat gaaaccaagg tgtctattgc
    18361 aggggcgata ttatataact taaagtattt cttcgcatgt ttcattacta tggtttgtat
    18421 tgtttctgta tttacattaa taggggcgtt aagtagaagt acgatgatta ctcttggatc
    18481 aggagtagcc tttattttct ttgctattgc aattccacag attttagaat tctctaacca
    18541 aacgataatt agcgctaata ctgtactaca ccttatgtac atgtcaatcg ttaaaattca
    18601 gcatacaggt atagcattta tactttcaac aagtaatagt ataaacattt atattgttat
    18661 agtggaagcg atttatattt tcctatttgg aatgttcgca tacctgtcat ttgtgaaaag
    18721 agattatttt atttgaaaac taggagggag tttaattgaa agcattagtt ataagtgaat
    18781 gggaacgact atggaatcag aaaaaaagca aatggatgtt ggggattttt actgtcattg
    18841 tttttcttca ggcttggttt ttaaagtact atggagtggg gatttataat gatgggcaac
    18901 aagttccact aaattcttgg aatttttcat ggtttttatt aaaggaatct tctttcttaa
    18961 ttactttgat tttcatgcct gtatgtttct tgaatagctt aaatgtagaa tacaactcag
    19021 gagcatatcg tctattttta attaggcctt ttcaacgtat aacctttctt atgtcaaaat
    19081 ggttttctct ttctataata gtgttactct acttatttgt tgttcttttt gttggcatag
    19141 tacttgggtt ggtgtttttt aaagccgatg atgcttttat gttctacggc caacaaaaga
    19201 ccgcgataga agcgatatta tatacagtac aagtatatgg attgtttttt attattcaaa
    19261 tgtgtggctt agctcttgct agtttaataa gtgtcataat ttcaaatgca gttattagct
    19321 ttttccttct gatcggaatc tacatcgggt gcttgtacat tagtcaatta tcgttctttt
    19381 tattatctgt ccagagtatc ttccatgcgc tcagcacagg aagtaacact ttatacgttc
    19441 tgattctagg tatcatgatt attagtgtta gcgtttgtat aagcatttgg aataaaaaag
    19501 aatttacatg ttaatgcaca ggatagaatg gaggtatacc atgattatgt tagaagctaa
    19561 aggaatcgaa aaagtttaca aaactaaatt ccgagaatat ccagttttaa ataatgtcaa
    19621 cttaactgtt catgaaggag attttgtagg aattatggga ccttcaggga gtggaaagtc
    19681 tacactttta aatgtacttt cctctcttga ttttccttca aatggagata ttacaattaa
    19741 aggacaaaat ttaactaata tggatggtga tcaattaagc aattatcgtc gtgaaaatat
    19801 tggttttatt tttcaaaatt ataatttgtt agatcactta acaattgaag aaaatattct
    19861 tctacccgca gctttaagaa tggggagtaa aaaaggtgtc agggataaac tcaatacatt
    19921 agggaatgaa ctaaatattg aatcactttt gccaaagtat ccctatgaaa tctctggggg
    19981 acaacaacaa agagcagcta ttatccgttc attaattaat gatccttatc tgttatttgc
    20041 tgatgaaccg acgggaaatc tagattcaaa atctgcttat gatgtattga atatactaaa
    20101 aacattgaat gaaacacata aaacaactat tttaatggta actcacgact ctgtagctgc
    20161 tagtttttgc aacagggtca tatttttgaa agatggcaag attgttcatg agatgcaacg
    20221 ttcctatgaa gaaaagcaat tcagtttcaa tcaacgtata ctactgtata tctctaaaga
    20281 agtgggggag aatgatgtca atattttcac tcgcacttaa aaatataact cgcaattttt
    20341 cactgtatat agtgtatctt gtaagtagta ttctatcagt tacaattttt tatatgtatg
    20401 cagcatttct ttcatatcca aaagtttctg gaatagagca actgttaatt gcatgtgaat
    20461 tcattatcct gctattttca tgttttttca tttcctattc ttatgaccat tttcttactg
    20521 aacggaaaaa ggaaattggt atttggaaaa cgttcggagc ttctaaaaaa caattattta
    20581 ttatcattgt tttagagaat acgataattg gagcaatttc tatcgtaatt ggaattatac
    20641 ttggtatagc actatcaaaa agcttttttg aattcatcgg gaaatcgctc ttcttaagtg
    20701 agtcattttc ctatttcttc tctccaattg ctactttttt tacagttatt ttgtttggag
    20761 ttctattctt ttttgtttca ttacgtagtt attataaaat tggacgcatt tctgttttgg
    20821 agttatttca agagacaaaa aaaacaaaag atttacctag gttttctaag aagaaattca
    20881 taatttccct gttaattttg gttatttcgt atgtttttat cctttatgca actttacctg
    20941 tactattatt ttcttttttg cctttatctg ctcttttatt gttagggacg tacctttttt
    21001 gttcacacgg attagtagga actgtatcgt atttaattaa taaagaaaaa aaacatttaa
    21061 atggcattcg aatgctaata tttataagtc taaggaaaaa actttattat aatgctaaaa
    21121 tcatctttct tgtttcaata ttcttatcaa tgataatgat attaatcagc tctatatatt
    21181 tatattcgga gttgaatgat caaagaatgc gaagtagcca cccacagcca gctgtattta
    21241 ttgttgataa aaaacaagag aatacattag aatctgattt agaaaaaaat ttcaaaggag
    21301 aggttgaggg atttcataag aaaaaatggg aaggtgtatt actgaaatca tcaaaggaag
    21361 aaggacaaac tcttatacta caaacaaatt cattctttat aaagaactgg acaaaaacaa
    21421 aaaaagataa cctgttattt agtaaaaaaa atgctaatat cgataagttg aatatccaaa
    21481 caaataaagg gaatacaaaa ttgatagtaa aaaatgtagt tgaaggacat gcgataaacc
    21541 cggtatctgg gatagataat gtagtttttg taccagcaga tatacttaat gaattagaga
    21601 agggaatatt acctactcaa catgtttcat tttatacatt agatttcaag gaagataata
    21661 agagttatag tgcactaaaa actttatttg aggcactccc tttagagata aaggaacagt
    21721 ccagcgttcg tcttcttcat tatgaaaata cagttcaatt aacttcagtt ttatggataa
    21781 tagcattatt tattggtttt atcttgctaa ttgctttatc cagtcttctt tggtttaagt
    21841 tatacgaaga tatatctaat gatagaaaaa tatttcacgc tttaagaaaa attggtttga
    21901 atttcaatga aataaaaaaa acattaagag ttcaaattgc aataattttc tttgtaccaa
    21961 ttattctcgg gggaataaat ctattcatag caatctatgc cttgcaaaat atattgggag
    22021 gatttaaaat ttactcaata atattaatat tttttatttt cttggtattc caattggtat
    22081 tttgcttcat ttcaaaccac gtttattata agaaggttgt tcatgaaaag aatattaatt
    22141 agcaagaaaa tatatttcac aaaataataa gagttttaaa ataaactaga gaggagtgtt
    22201 tttttgaatg gaacgattct tgttgtagat gatgagtcag aaattgtaga tgtactctct
    22261 gatatattct gtgatcgggg ttataaagtt ctcaaggcct acaatggaga acaagctcta
    22321 aatcatttga aaacacaagt tgatttagtc attttagata ttatgatgcc aaaaatggac
    22381 ggttttgaat tttgtaaggt cgttcgtgaa caaataaaat gcccgattct atttttgagt
    22441 gctaaacatt cagaaataga taaagtgaaa ggctttactt taggtggaga tgattatatt
    22501 acaaaaccat tccaagttaa ggagctcatc gcacgtgtgg aggcccactt gaggcgtgag
    22561 aaaagagaac gtgtaaactt gcaaaatcaa cgtttcttag gaaacttgac cattaactat
    22621 ttacagcatg atgtttttat tgatggagta aaaatagatg taacgagtaa agagtttaaa
    22681 atattagagc ttttaacggt aaatttagga caaatttttt ctaaggaaca aatttatgag
    22741 aaaatttggg gattggatgc agtaggagat ctcaatacaa taatagtgca tattaataac
    22801 ttaagagcta aattaagttt gggtatgtca acttaccata ttaaaaccgt atggggagtt
    22861 ggctataagt tggagaaatg ttaatgttaa aaaaattatc gttgaaaaac caatttattc
    22921 taacatttgc agctgtaata tttttaagta ttgtcagtac ggtttgtacg ttaattttaa
    22981 tatactcttt tctttttatt tataatgaaa aatctgtttt acctgccaac cattatgaaa
    23041 aacaagtgcc tagcattgaa aaatttgtag aaatgaatgg agataaaata gtagatttat
    23101 cctatcaaaa aaaaatagag aaagtgattc caatgcaagg aattacttat caagttatga
    23161 atacgaatgg aaataggtta tatggtacat tgagtgatga attattgaaa aacgataaag
    23221 aagtgtatca taaaataaat acctctactc aaaatggtaa actaattaca aaatacattc
    23281 caattatgag taatgatcaa ctagttggtg tgcttgctgt acgatacata ctagctgcat
    23341 ctattgatta ttacatagaa tatgttttta ttattgcttt tcttattcct tttatatttt
    23401 taacgcttta ttcttatcta ttagctaaac gtttaggaaa acaattgaat aaacctatta
    23461 aagaagtaat aatggcctca caaaaaatta aaaacaaaga tttagacttt gaaataaaat
    23521 atgaaagtga aaatgaaata ggtatattaa ttgattcatt taacagtatg aaggaagaat
    23581 taaaaaattc attatatgtt caatggaaat tagaacagga acgtcgggat atggttgctt
    23641 ccattgcaca tgatttgcga acaccgctaa ctattatttt gtctcatgta gaagtattaa
    23701 tggagcccat gccaaataat caaaaacgac ttcatcacta cttacaaaca ataaagaata
    23761 ataccgaaag agtattgcat ttaaccgaag agatgagaag aatttctgaa gtggataacc
    23821 ctgatttcac tcttatgatt tgtaatatag ctccagctga aatgattcca gaaatgcttg
    23881 aagagtttaa ggaattggca aaaaatgaag atatccaatt aacctatact ttacttatta
    23941 aaccagaaga aaaaaatctt aagtttgcac ttgatccaaa tcgcttgcat caaattctga
    24001 cgaatattat ttctaatagt attcgcttta cgccaaaaaa aggaaggatt aatgtgcaag
    24061 tggaggtgaa aaaagacgtt atgtcttttt ctatctcgga ttctggagtt ggatttaata
    24121 ctaaagatat tccattttta tttagtaaat tctaccaagg ggatctttca aggtcaaatc
    24181 aactacatca tggactaggt ttgtatattg tagaaaaatt ggttgaaaaa catggtggag
    24241 aaattcatgc tgaaaataat gagattcaag gagctcggat ttcattcacg atacacgctc
    24301 tgtttagtaa taaaaaaagg aactatgaat tgtcatagtt ccttctccgt tatttaatag
    24361 cattatatac atccagctgt ccgtaccccc aagaagcttt atcaggtgct atatctttct
    24421 ttattccatt tttgtaaagg tgtgaaattg atcgatttgg ttgattttta taattatagt
    24481 gattgataat tagagctagt gtagcggata ctttcggaac tgccatcgat gttccagcgg
    24541 caaataagta tcttccagta ttaaaagttg tcagtacttc ttcttgtcgg aaaagaccag
    24601 tattccacca tacctcttcg ccatattgtt gccacaaacg ataatctcct cctggagcag
    24661 atatgtcaat gaatccttct ccgtaattag agaatacaga acgttgtcca gttggaccag
    24721 tagacgatac tgttactaca cctggtaatt ccccaggtgc ttctattcct acaccagtat
    24781 atgttttacc ctctttttca tatttttgtt taagaaagtt atttagctcc tgtttattag
    24841 ccacgtttat agaatcattt cctgcagaag ctactactat actaccacgt tgattggcat
    24901 attctatagc acgtttgtaa ccttctactt ctgcccatcc attgtctaca agttttccat
    24961 tttcatagac ttttccattt acataatagg aaccaagact aaggttgatg acatctacat
    25021 catccttagc tgcttcgatg atggcattaa tgacccaagc tgcatcagct gatttatttc
    25081 caaatacacg atatgctctg attcccgtat taggagcaac accttttatt tccccatttg
    25141 cagcaataga tccagtaacg agagttccat ggccgttgat atcattgata ttattaatat
    25201 cgcctgtttc ttcaggttca gtacctctca atcctccttt tggaacgaaa tttttagatc
    25261 cgggaataag gttttttact aagtcaggat gatccacatc gactcccgaa tcaataattc
    25321 caacaaccac attatgagag ccagtttcct ttttataact ttctccatta tgagtaagtt
    25381 ccttcatgtc ccactgcata tcccataagg gaggtaggtt tgtatctaag gtttttgttg
    25441 aaaaattaga taaattaggt atctttatgg aatgagaaat ctctggtgtt tcgacttgca
    25501 aagaaggatt aactgattcg aataaaggag attgatttgt agacacttgt gtatctcctt
    25561 tgaattgaat gagtcctatc tccgggacag tgtaagtaat ttctccatcc ttctttttta
    25621 tttcggtaat gccttggtct aattttgatg ggtcttttaa taaaacggtg taatattgct
    25681 taggtttttc ttgagcatgt cctacatttg aaaataaaaa atacgttaac acggttgcaa
    25741 tgacagtgat tgcttgtttt ttcataatta tccccttacc tttataaatt ggaggtggaa
    25801 tttgaagatg gaccgcaaaa taagttttga caaatacccc tattgcccat tttgctatcc
    25861 cacctagatc ctataaataa ggtaacaaac cattggaaat ttcaaatccg taaatcccga
    25921 acttataagt ggtatatagc gcaatatact tctttatgta aacaccctgg aatttctact
    25981 ctagatttat ttccaaagaa ataattcaga aaatacagaa aaatatcgta atcatttgta
    26041 gaagtctgtt ataataaacg gaaaatgaaa acgttttaaa gggggacata accaatatga
    26101 tgatgaatgt accgctaaca attagttcta tgatggaaag agcagagaaa ctgttttcga
    26161 agaaagaaat tgtttcacgg acgcatgata cagttacaac gttaacgtat aagcagttag
    26221 gggaaaggac gagaagactt tccagtgcgt tgaaaaagct tggaattaaa gaaggtgaac
    26281 gtgtaggaac attagcgtgg aaccatcatc ggcatgtgga agcgtatttt gctattccag
    26341 gtattgcttc tgttttgcac acaattaaca ttcgtttatc tcctcaacat atttcataca
    26401 ttattcagca cgcagaagac cgaattctac ttatagatga agat
//
