LOCUS       NZ_NKAX01000023        25239 bp    DNA     linear   CON 03-APR-2024
DEFINITION  Bacillus cereus strain 32-6 32-6_R1_(paired)_contig_23, whole genome
            shotgun sequence.
ACCESSION   NZ_NKAX01000023
VERSION     NZ_NKAX01000023.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus cereus
  ORGANISM  Bacillus cereus
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 235225)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 235225)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009935145.1-RS_2024_04_03
            Annotation Date                   :: 04/03/2024 04:19:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,979
            CDSs (total)                      :: 5,895
            Genes (coding)                    :: 5,727
            CDSs (with protein)               :: 5,727
            Genes (RNA)                       :: 84
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 76
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 168
            CDSs (without protein)            :: 168
            Pseudo Genes (ambiguous residues) :: 0 of 168
            Pseudo Genes (frameshifted)       :: 62 of 168
            Pseudo Genes (incomplete)         :: 100 of 168
            Pseudo Genes (internal stop)      :: 56 of 168
            Pseudo Genes (multiple problems)  :: 40 of 168
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:34
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 68022
            Orig. end                         :: 93261
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NKAX01000023.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="2"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15239)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(501..1238)
                     /gene="mtnN"
                     /locus_tag="CE086_RS25365"
     CDS             complement(501..1238)
                     /EC_number="3.2.2.16"
                     /EC_number="3.2.2.9"
                     /GO_function="GO:0008782 - adenosylhomocysteine
                     nucleosidase activity [Evidence IEA]"
                     /GO_function="GO:0008930 - methylthioadenosine nucleosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019509 - L-methionine salvage from
                     methylthioadenosine [Evidence IEA]"
                     /codon_start=1
                     /gene="mtnN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="CE086_RS25365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="5'-methylthioadenosine/S-adenosylhomocysteine
                     nucleosidase"
                     /protein_id="WP_000151939.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERVEKRAAWEFHF
                     HTINELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRSYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNNR"
     gene            complement(1235..1909)
                     /locus_tag="CE086_RS25370"
     CDS             complement(1235..1909)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="CE086_RS25370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3885 domain-containing protein"
                     /protein_id="WP_043924663.1"
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLGPYLYSQWGNHLHFDFGKDKYQIVEGTND
                     LNMEYFSQLYTYNKFLFEDIFSKEDVVFVVTNVYRFKKENIKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADLYCTYHFSLKCLAEDIKYELLIQAANHEDFSALYPRFGRK
                     KEISYPDVFLINATKDIVMFMCDDRGCEVIAKNKEIIRDLYKKYKEWIPDYERESIDNL
                     FK"
     gene            complement(1923..2531)
                     /gene="yqeK"
                     /locus_tag="CE086_RS25375"
     CDS             complement(1923..2531)
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016124593.1"
                     /locus_tag="CE086_RS25375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_063547343.1"
                     /transl_table=11
                     /translation="MLCNDIYLFTPTGKIDNDIKAFLLKYNKEFTYKHSIRVANEAKKI
                     AEKFHVDKEKAAIAGYLHDISGIFPNEERIAVAEEFGVEIVETERKIPMIIHQKLSRVI
                     AKEIFKVEDEEILNAICCHTTLRKHATKMDLVLFVADKIEWDQNGTPPYLIEIKKGLEK
                     SLEKAAFVYISYLWERKDTLKVIHPWLEEAYWDLKGILQ"
     gene            2724..3419
                     /locus_tag="CE086_RS25380"
     CDS             2724..3419
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="CE086_RS25380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038809.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKLIHTV
                     WGVGYKIEK"
     gene            3409..4566
                     /locus_tag="CE086_RS25385"
     CDS             3409..4566
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129473.1"
                     /locus_tag="CE086_RS25385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_001243312.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYRHEKKLYYET
                     CIKKMIEEIRYIANGNFNHKVSIVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKC"
     gene            4742..5758
                     /locus_tag="CE086_RS25390"
     CDS             4742..5758
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="CE086_RS25390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_063547342.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSATLSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGTEDNFTILMNKKAKELQLLQPSPFLNS
                     TGINHDTNKQSTTTAIDAAKLAARLVKDFPDVLNITKLTSYQFTFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLGDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFKDTLTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(5820..>5930)
                     /locus_tag="CE086_RS25395"
                     /pseudo=""
     CDS             complement(5820..>5930)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="CE086_RS25395"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VLRHVIVHEIHHIGQLSIWARELNLQPVSANLIGRG"
     misc_feature    5934..5943
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            6096..6233
                     /locus_tag="CE086_RS25400"
     CDS             6096..6233
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="CE086_RS25400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     misc_feature    complement(6324..6340)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.65"
                     /tool="antismash"
     misc_feature    complement(6780..6796)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.51"
                     /tool="antismash"
     gene            6947..7555
                     /locus_tag="CE086_RS25405"
     CDS             6947..7555
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807974.1"
                     /locus_tag="CE086_RS25405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_088020314.1"
                     /transl_table=11
                     /translation="MTEIKVGLTQFLDFTLKGSTAKTTFIKNLKSQPEYQPAFDYWKQL
                     RETVIKFHQNRLPFEYFETLVQTVDQKKKQNYIDVIKQYKKFIKNKDISWFDPGKSHWK
                     SDDLIVRSSPELGLFINNEPHLIKLFFKGKKERIDKYNINSTLTLLNESTFSNERNDVN
                     YTVLNIQKNRMYTNNSINNNHLVALKSEANQFCYIWNNL"
     gene            complement(7826..8359)
                     /locus_tag="CE086_RS25410"
     CDS             complement(7826..8359)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002007691.1"
                     /locus_tag="CE086_RS25410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family protein"
                     /protein_id="WP_120460042.1"
                     /transl_table=11
                     /translation="MMYERSMEVIKLKTFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEETSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKNMMKAVLHIAFDELKLHRVTLGVYDFNISAISCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     misc_feature    complement(8435..8450)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            complement(8465..8821)
                     /locus_tag="CE086_RS25415"
     CDS             complement(8465..8821)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="CE086_RS25415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000535577.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDVVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     gene            9419..9679
                     /locus_tag="CE086_RS29530"
     CDS             9419..9679
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CE086_RS29530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_202626578.1"
                     /transl_table=11
                     /translation="MIAGVLRKSIVMMIGGNLKKSVIVMMIGVLNEISVVVNVSLFVAI
                     VKEKIGNIFNVNVKKKICLLESIGLFRKVDPSPTSLLSLNF"
     gene            complement(10001..11941)
                     /locus_tag="CE086_RS25420"
     CDS             complement(10001..11941)
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 3.9e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_CE086_RS25420_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="CE086_RS25420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_000806506.1"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-89, bitscore:
                     293.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYSWMKSLGYEDYETFYNKSIEETAWLW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDEVKGEVCHCFAVLREGVIFTEDLKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     CDS_motif       complement(10346..10408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE086_RS25420_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="CE086_RS25420"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     aSDomain        complement(10379..11644)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE086_RS25420_AMP-binding.1"
                     /evalue="3.90E-82"
                     /label="CE086_RS25420_AMP-binding.1"
                     /locus_tag="CE086_RS25420"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       complement(11099..11155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CE086_RS25420_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="CE086_RS25420"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     gene            complement(11991..13532)
                     /locus_tag="CE086_RS25425"
     CDS             complement(11991..13532)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389703.2"
                     /locus_tag="CE086_RS25425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000886755.1"
                     /transl_table=11
                     /translation="MLDQKQQSNTFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            complement(13535..14323)
                     /locus_tag="CE086_RS25430"
     CDS             complement(13535..14323)
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 5.8e-74. Score:
                     240.4. Matches aSDomain:
                     nrpspksdomains_CE086_RS25430_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="CE086_RS25430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_063547339.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLDELQTILTQI
                     SEDSNVRVVILTGAGEKAFCAGADLKERANMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAECTSLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKKAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRTPTYKGE"
     aSDomain        complement(13562..14281)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE086_RS25430_ECH.1"
                     /evalue="5.80E-74"
                     /label="CE086_RS25430_ECH.1"
                     /locus_tag="CE086_RS25430"
                     /protein_end="254"
                     /protein_start="14"
                     /score="240.4"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLDELQTILTQISEDSNVRVVILTGA
                     GEKAFCAGADLKERANMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAECTSLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKKAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            complement(14328..15239)
                     /gene="mvaB"
                     /locus_tag="CE086_RS25435"
     CDS             complement(14328..15239)
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="CE086_RS25435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_161520446.1"
                     /sec_met_domain="HMGL-like (E-value: 6.1e-49, bitscore:
                     160.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEEITKQALFEGKKVRGYVSTVFGCPYEGDISVTAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGIKTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            complement(15261..15476)
                     /locus_tag="CE086_RS25440"
     CDS             complement(15261..15476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="CE086_RS25440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            complement(15503..16840)
                     /locus_tag="CE086_RS25445"
     CDS             complement(15503..16840)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="CE086_RS25445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_161520447.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1e-11, bitscore:
                     38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.3e-07, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 1.1e-07, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.8e-10, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKCSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            complement(16856..18001)
                     /locus_tag="CE086_RS25450"
     CDS             complement(16856..18001)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="CE086_RS25450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397282.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.8e-41, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.7e-27, bitscore:
                     89.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.8e-58, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            complement(18218..19186)
                     /locus_tag="CE086_RS25455"
     CDS             complement(18218..19186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="CE086_RS25455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_161520448.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRVVQPSTREDVTEKMEQFSNDFLQTIPDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGSGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNIKDLVSFQSDNKYLFMAYNQVKQKELGRIIANQKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            19420..19719
                     /locus_tag="CE086_RS25460"
     CDS             19420..19719
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="CE086_RS25460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_161520463.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLALSIMFLGTSTKAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            complement(19841..20494)
                     /locus_tag="CE086_RS25465"
     CDS             complement(19841..20494)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168191.1"
                     /locus_tag="CE086_RS25465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_016512809.1"
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYERLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQEEGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWNDEAEIENTIQFILYGLTPRF"
     gene            complement(20519..21538)
                     /locus_tag="CE086_RS25470"
     CDS             complement(20519..21538)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="CE086_RS25470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_161520449.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKVMKNQEASIYEYSKEKAISELEKQKIDAILQIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPMESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSILFAVGNVFALKKHRKI"
     gene            complement(21535..22260)
                     /locus_tag="CE086_RS25475"
     CDS             complement(21535..22260)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="CE086_RS25475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_161520450.1"
                     /transl_table=11
                     /translation="MQQPSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNTNIPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKRKKTRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVPS"
     gene            complement(22448..22699)
                     /locus_tag="CE086_RS25480"
     CDS             complement(22448..22699)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="CE086_RS25480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            complement(22916..23758)
                     /locus_tag="CE086_RS25485"
     CDS             complement(22916..23758)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="CE086_RS25485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphoesterase"
                     /protein_id="WP_161520451.1"
                     /sec_met_domain="Metallophos_2 (E-value: 6.9e-09, bitscore:
                     29.6, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICILVGFTIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKMKSIDPDIIAITGDLIDSKSYDAEVSMQLIREM
                     VKKYPVYFVTGNHEQWSGKYNSLEKELKKYSVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     GTGNRDEGNIIIDEIKKAKIEMQPDRYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGVLPKYTAGLYVEQNTSMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            complement(24019..24945)
                     /gene="bla"
                     /locus_tag="CE086_RS25490"
     CDS             complement(24019..24945)
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="CE086_RS25490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_161520464.1"
                     /transl_table=11
                     /translation="MILKNKRMLKIGICVGILGLSITSLEAFTGGALQVEAKEKTGQVK
                     HKNQATHKEFSQLEKKFDARVGVYAIDTGTNQTISYRSNERFAFASTYKALAAGVLLQQ
                     NSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGG
                     PKGYEKALRKMGDRVTMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RKILTEWIKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAIL
                     SSKDEKEATYDNQLIAEATEVIVKALR"
ORIGIN
        1 aatgacttcg agaaaaagtt gcttacatcc atgttgaatc gcctcttctt tatgcagttc
       61 aaataatttt tgactgacac caataccgcg gtaattagga tgaaccgcta atgttccaca
      121 gcgcatagtc tttatacttt cataatcctt tataccacct aatattacgc caactgattt
      181 gtcaccgtct aaagcaagaa aagaatgttc tagcaaatta ccttctggtc ccaaaaaacg
      241 gtgtataaaa tcaccttttg aaacttccat cttaataata taatcggaaa atccatcttt
      301 aaaagcttca tatactaaat caatatttac ttcactacat cttttatatt gaatcatata
      361 aaattgccct ccaattgctt gtattaaccg caacatgtac ccatataata tattccatct
      421 attataaatt tcagctctta atttgaaatg aacggacatt tccctacata taacccacta
      481 ttaatttgtt ttataacaaa ctatctatta tttactacat taatctcata aacacgcaaa
      541 aaagcaatta aatgctcaca tgctctttcg catgctagca ttttaaagat tttttgttct
      601 tctttcgttt tatcatttgc ttgatctgaa gcagctttta aacatagaaa tggtttttta
      661 tttatttggc atacataggc gaaagctgct acttcttgat caactgccaa tgctccatat
      721 acggtatgga gtaaatatct catttctgaa ctacgaatac gttgatctcc ggataaaaat
      781 gtaccgaaat gtattggatc atatgatcgt atttttttta ttcttcttac aagtgatttt
      841 gttgtttcaa taggtgctgt tctaccgtta tataaattaa aaacatcttc ccctgagcca
      901 gctgcagtaa catcgtgttg tattgcgttt agtgccacta caatatgacc gtttttcacc
      961 ttgtttgata aacttccgca tattcctgtc ataaacaact catctggctg aaactcacta
     1021 attaacaatt gtacacaact agcgcagctt actttaccaa caccagtaac aactgatata
     1081 atttccagct cattaatagt atgaaaatga aattcccaag ctgctctttt ttcaacacgt
     1141 tcactcggat aatgttgatg caaatacgtc agttctggtt cccatgcaga tactattgca
     1201 atacgtttca ttacacgctt cacttcccct attgtcattt aaataagtta tctatacttt
     1261 ctcgttcata atctggaatc cattctttgt atttcttata taaatctcgt attatttctt
     1321 tattcttcgc aattacttca catcctctat catcacacat aaacatgaca atatctttcg
     1381 ttgcatttat gagaaataca tctggataag aaatttcttt ttttcgtcca aatcgaggat
     1441 acagagcaga gaaatcctcg tgattagcag cttgtataag caattcatac ttaatatctt
     1501 ccgcaagaca ttttaaagaa aaatgatatg tacaatataa atctgcttct tcatcttcaa
     1561 atagaaacgg taacgtttct tgtcttatat gaaatcttaa atctcttttc ttaatatatt
     1621 tattgtatac atttattttc tgtggagttt ttatgttttc ctttttaaat ctataaacat
     1681 ttgtcactac aaacactaca tcttcttttg aaaatatgtc ttcaaataag aatttattat
     1741 atgtatatag ttgagaaaag tattccatat ttaaatcgtt ggttccttct acaatttgat
     1801 atttatcttt tccgaaatca aaatgtaaat gatttcccca ctgagaatat aagtagggtc
     1861 ctaatgtaac tcctggaaat gtttgattca tatattcttt taattgcatt tccttgtcct
     1921 ttctactgta aaattccttt taaatcccag tatgcttctt ctagccacgg atgtataact
     1981 ttcaatgtat ctttcctttc ccacaaatat gaaatatata caaaagctgc tttttccaaa
     2041 gatttttcca atcctttttt tatttctatt aaatatggtg gtgtcccgtt ttgatcccat
     2101 tctattttat ctgcaacaaa taatactaaa tccatcttcg ttgcatgttt acgcaacgtt
     2161 gtatggcaac aaattgcatt taaaatttct tcatcttcta ctttaaatat ttcttttgcg
     2221 attactctcg ataatttttg atgaataatc ataggaattt ttctttctgt ttccactatt
     2281 tctaccccaa attcttcagc aactgcaatc cgctcctcgt tcggaaaaat gccactaata
     2341 tcatgtaaat atcctgcaat tgctgctttt tctttatcta cgtgaaactt ttctgcaatc
     2401 ttttttgcct catttgccac acgaattgaa tgtttatatg taaactcttt attatatttt
     2461 agtagaaaag ctttaatatc attgtctatt tttccagttg gagtaaataa atatatatca
     2521 ttacataaca tagaaaatcc cccttataac taacttccat tataatgtag aatctaaata
     2581 tccttgttat tttatattcg ttattaatct ttttactcct ttttaatacg ttacatgaaa
     2641 ttttatacag aatcatcgct acaagtacat aaatgtttga tattatagta atgttgatga
     2701 tttgtaagga aaggaactac acaatgaata aaaatatatt aattattgat gatgataaag
     2761 aaattgttga attacttgct gtttatttgc gaaatgaagg ctataacatt tataaagctt
     2821 atgatggcga tgaagcattg caaaaggttt ctacatatga agttgatctt atgattttgg
     2881 atattatgat gccaaaacga aacggattag aagtttgtca ggaagtgcgt gaaaataata
     2941 ctgtaccaat tctaatgctt agtgcaaaag cagaagatat ggataaaata ttaggcctta
     3001 tgacaggtgc cgatgattat atgatcaaac cattcaatcc attagaatta gtagctagag
     3061 tgaaagcttt attacgaaga tcctctttcc aaaatgctac ttcgcaaaag aatgaagatg
     3121 gtattattcg tattcgctct gttgaaatac acaaacataa tcatacagtt aaagtaaatg
     3181 gagagtatat taaactaacc tctattgaat tcgatatttt atatttactt gcgagtaata
     3241 caggaagagt atttagttca gaagaaattt tcgaacgcgt ttggaatgaa gatggttatg
     3301 gttcaaataa gacggtaatg gtccatatta gcaacttacg agataaactt gaaacagtaa
     3361 tgaatggaga aaaattgatt catactgttt ggggagttgg ctataaaatt gagaaatgaa
     3421 gcatttgata tattaaaaga tattcctaaa tggaaactta ttttttggct tttattagct
     3481 atcacactca ctcctattac tgaactaatt atttatcgcc tcgttacgag tgtaattgag
     3541 agttcactta ctctaactga actcggtaaa gaattcattc gaatttttgg ttatgaaaag
     3601 tataaaggga ttaaagagtc tttatggatg atgattgtat cttatttgtt tttattttct
     3661 attttttcat cctatcttta cattttttat cgtcacgaga aaaaacttta ttatgaaact
     3721 tgtataaaaa aaatgataga agaaattcgt tatattgcaa atggaaactt caatcataaa
     3781 gtttctattg taaatcataa ttatctagaa gaattagcaa tcggggtcaa tgaaattgtt
     3841 gaacaattaa aagtctccat tgatgaagaa agacaagcgg aacaagcaaa aagtgaactt
     3901 attacaaatg tatcacatga cttacgcacc ccccttactt ctatagttgg atacgtaaat
     3961 ttaatccatc atgataatta tagagatgaa gtggaattgc gatactatat tcaagtcatt
     4021 tacgataaag taactcgtct taatgcatta atgaatgact tgttcgaata tacacgtgtt
     4081 caaaataaag aattaagctt gtattctgtt cctattgata ttgtagagtt acttggacaa
     4141 ttaactgttc aattccgcat acaggttcaa gaagctaata tagaatgtcg gccttctttc
     4201 ccgtctcaaa agcttatggt attagctgat ggtgacaaat tagtgcgtgt gtttgaaaat
     4261 cttattataa acgctatcgc ttatggaagc gaaggtcgct atattgacct tactgcttat
     4321 gaaagcaata atatgattac aattgatata acaaattacg gacaacctat tcctagtacg
     4381 gatttacctc atatttttga acgtttttac cgcgttgaga aatctcgctc tacaaacact
     4441 ggtggatctg gacttggatt agcaattgca aaaagtatag tcgagttgca taaaggaaca
     4501 attgaagtat atagtgatga cgaaaaaaca acattcactg taaaactact tccatacaaa
     4561 tgttaatatt acaaataaaa agttcaattt cttatcatat aagaaattga actttttcta
     4621 ttatttccct aaatttaata atcctttata attctttaga aattctttac cttttctttc
     4681 ttcctaatta agcattcctt tttacaatac tattattgat gtcataatag gaggatcact
     4741 tatgcaattc ttaaaaaaat tcgctatttt attattatct tttttcatta ctgcacttat
     4801 cgttttatat ttttatcttt atgtaaatgg tccgattatt caagctaaat cagctatttt
     4861 aataaatgct aattcaggtg aaattgttta taaaaaaaat gaagaaaccc cagtacaatc
     4921 agctacttta tctaaattaa tgacggaata tatcgtattg gaacaactaa atgatagaaa
     4981 aatacagtta gatgacttcg tacaaataag taacgaagtt ttccgagtag aaacaagccc
     5041 tatacaagta acatcgaatg ataaaacaac ggttcgtgat ttacttcatg cattgctact
     5101 ggcagggaat aatcgttctg cactcgctct agcagaacac attgctggaa ctgaagataa
     5161 ctttacaata ttaatgaata aaaaagcaaa agaactacag ttattacaac catctccatt
     5221 tctaaactct actggaatta atcatgatac aaataaacaa tcaactacaa cagcaataga
     5281 cgcagctaaa ctagctgcac gcttagtaaa agattttcca gatgtattga atattacgaa
     5341 actaacctct taccaattta ccttcaaaga ttcccaggtt ttcaatacga ataaaatgat
     5401 atattccctt aatgaaaaca ttaaacttca aggtgttgat ggcttacaaa ctagtttttc
     5461 aactaacggt aattatagtt ttgtcagtac agcaaaacta ggagatacta gactaatttc
     5521 agtaatatta gatgcagatg aagaaaacat ctcatttatt gaaacaaaaa agttgctaca
     5581 gtatggtttt gatccttcct cgtactctgc actccaagct tttaaagaca cccttacatc
     5641 ttggacaata ttgcttcagt ttaaaaactt aattatacaa actataatga ttttcttaat
     5701 cattaccacc ttaatgtttt tacatatacg tcagaaaaaa tccgaagatt tcaattaaga
     5761 aatcttctta tatataaaaa ccgacttgcg cttgagatgc aagtcggttt ttaattctat
     5821 catcctcgtc caatcaaatt tgctgaaact ggttgcaagt ttaactccct cgcccatata
     5881 gatagctgac caatatgatg gatttcatgt acgattacat gtcttaaaac ctatgttttt
     5941 tgaggcatac atccatctct gtttcctttc gttgtattcg tttgtttagt ttaaatgggt
     6001 taatctatta attctattaa atccaacaat ttaactatta cactttaaag ttctattcat
     6061 atactatagt agattactag aaaggaggtt taactatgga tagttgcgtt gtatttgtaa
     6121 acggacaacc ttttttagtt ctttcagtag ctggtattga aattgctaga ttagagattt
     6181 cccttcaagt agcattagct ctaagagtgc ttgggatacc aatctgtgat taattaccaa
     6241 attaataaga aaagagggca ttagccctct ttttttattt tcttctcacc ttttcttaac
     6301 aacaaataaa atttaaattt tatttgttat attgtaatga aaatccgaaa aatcaaccca
     6361 ttttattcaa taaaaaagag caccacccat acctcattat ccgtttctat aatattcaag
     6421 tttgattaat aataaaatta aagtatatga acgttacatg aaacacttgt taagatagct
     6481 ctccttcaca ctatttattt cgctgacgct atattatcaa agcacacaat gattaacttt
     6541 ttatacggct tattttaagt atgcttgcca atacttttac ttgtatgttc tatacactca
     6601 ttctctacgg tatactgata ccaacttata ttttttgatg agggcccatt tccctatatc
     6661 cctctttatt cccatgtact ttttttctca aatccaagct aaataatcta tattgttatc
     6721 ttttaaaatc agctcactat ctgattatat taataaccta tcacctggta aaatcctatt
     6781 acctaattta tcttcaattg aatggtccat catttatact tacggattgg ctttcccgta
     6841 tctattgtgc atggatattg gattttctag catctagctc atttctttaa aaatgtcgga
     6901 tttttcgtct attattaaat gaataatgtt tggaagggga tataatatga cagaaattaa
     6961 agtagggctt acacaatttt tagacttcac actgaaaggt agtacagcta aaacaacctt
     7021 tataaaaaat ctaaaatccc aacctgaata tcaaccagct tttgattact ggaaacaatt
     7081 acgagaaact gttattaaat ttcatcaaaa cagactacct tttgaatatt tcgaaacatt
     7141 agtacaaacg gttgatcaga aaaaaaaaca aaactacatt gatgtcataa agcaatacaa
     7201 aaaattcatt aaaaataaag acatctcttg gtttgatcca ggtaaatcac attggaaatc
     7261 agatgattta atcgtccgtt catcacctga acttggctta ttcattaata atgagccaca
     7321 tcttatcaaa ctgtttttca aaggaaaaaa agagcgaatt gataagtaca acattaactc
     7381 gacacttaca ctattaaatg aatcaacatt ttcaaatgaa cgaaacgatg tgaattatac
     7441 ggtacttaac atccaaaaga acagaatgta tacgaataac tctattaata ataatcattt
     7501 agtagcgctt aaatcagaag ctaaccagtt ttgctatata tggaataatc tataaaggat
     7561 actattcatc cctttcaata cattattgat gcatacttta gttacaattt ttccagattc
     7621 attcagtttc gtttaattat ggctcaccct cttattcctc agaaacaatg caggtgggcc
     7681 tttttcaaaa atggtttctt tgttagtttt aacatactag ctctcccccg aaacagctgc
     7741 aattaagatt atttttgttt tattatccac tatacccacc aatccccttt tgttaacata
     7801 atataattat aaattactat cgttgctact tcttccattc atattctaac atactcattt
     7861 cccataaatt ccaatacgtt tctcctactc tttttgactc tcttaataag ccttctttta
     7921 caaaccctat tttttcgtaa catgaaatgg ccgatatatt aaaatcatac acaccaagag
     7981 ttactctatg tagttttaat tcgtcaaaag caatatgaag tactgctttc atcatatttt
     8041 ttcctataga acgtcctctc atcttcgtat taccaactaa tacttttcca attctagcgg
     8101 acttattaat attatctatt tgcccaagcg aaatatgacc aataacgtct gaagtctctt
     8161 catccaccac tttgaaagcg agtgtatttg cactttctat atacttctct aattgctgtt
     8221 cgtctaaagg gaatgtgaat gcatttcctg accattgtat tagaaattct tcagaattaa
     8281 tccaatttat taattgttta aaatcagatt ttttaaaggt ttttagttta atcacttcca
     8341 tgctcctttc gtacatcata ctttataacc tcaaacttat ttctatataa agaatatatt
     8401 ctccttttat atgaaattaa aataaagcca ttcatgtgaa tggctttaca aaaaagcagc
     8461 ataattatgc tttgtttgct acatcaatac cattaaaatc aaagtcagca gtaaccgttg
     8521 taacaggtgg gaaaattgct tcaattttac aaatggaaat aattactcca accgatccag
     8581 gaatagccgc aagcctaact acatcacaac ttacagacga aacagtacct acataagtac
     8641 gtccctctgt attaatttga actgttcgat taattaattt cttaagttca tctctaattc
     8701 cttgtacaca agaattatca catttctcat gctgttcttt tttacactct tcgaatactt
     8761 cccaacaatc atcttgttta catgtacact tctttttaca attattaaat cgagaaccca
     8821 atacctcacc ccctaatcct ttctattagt aaagtatgtc cactagctta aaagggtacg
     8881 aggcaaacac ataaaaagaa aaaaacaaac aattgtacca aaccttcttt tcattattca
     8941 ttataaaaac agacttctcc taattaaaat cttgtttaat gagcggccgt gaatttagtc
     9001 ctactccatt taatgtttag acaccacttt ctaaaacaaa tctttttctt ttaataagat
     9061 gccccttaaa aacacactag attttcccat taactcacat atacatagac tttatttgtg
     9121 gatttcccat ttttcattgt gaaatataca tttaaaaaag cgtactcgaa aataagatat
     9181 tatatgtaat cagaacgctt tcttcaacaa atgtttattg gaaaacacca taactagtag
     9241 tagttctctc cactatctct taaaaattag catagtttgt atgaactcta tatcgagtag
     9301 aaaacactct atcatataaa gataaaatag taggttaata aacaagccat tttttttatt
     9361 aaaacataga ataatatgaa cactattgaa aggaggtaga aatgaatgtc ttggaaaaat
     9421 gattgctgga gttctcagaa aaagcattgt aatgatgatt ggtggaaatc tgaagaaaag
     9481 tgtcatcgtg atgatgattg gagttttaaa cgaaataagt gtcgttgtaa atgtttcttt
     9541 atttgttgcc attgtaaaag aaaaaattgg taatattttt aatgtcaacg taaagaaaaa
     9601 aatatgtctt ttggaatcaa tcgggctttt ccggaaagtt gatccctcac ctacttcctt
     9661 gctttcgctg aatttttagg tgggggcatt actgcccggc aaatagcgag ataaatacta
     9721 ggatgtaata tataaaaagc tgactgagta tagtcagctt tttatcaatg aatacgtaaa
     9781 ggtttaaacc ggcatataag tagtcgcgct ttgtcatcac cttgttgttg taaattagta
     9841 tttctccatt gaatagacat tccataatat cgtattttga ttaaaactaa aaaacatact
     9901 taacaccaat agtagaattt ttcttcttca tcaaattcac tttttttctt tttattaaca
     9961 taaaaaagga gctctgttta tatagagctc ctttctaatt ttataattta ctagactgta
    10021 acccctgaat aaacggtact acttcaggat ttacaagtga cgacaaatca cctaattctt
    10081 ttcctaaata agctgcttta ataacacggc gcattacttt agaattacgt gttttcggta
    10141 aatcctctac aacgtggatg tctttaggac acaacgcttt gccaatatgt gagtttacta
    10201 aactcattaa ttctttcttt aaatcttctg taaatattac cccttctcgt aatacagcaa
    10261 agcaatgaca aacttcacct ttcacttcgt caggtacacc aattgcagca gcttcgatta
    10321 catcgttatg tttcacaaga atagattcat attcagcagg tccaatacgt ttacctgcaa
    10381 tatttaacgt atcgtctgaa cgccctgtga tgatatattg ttcaccatcg taaatgaccc
    10441 agtcaccgtg gacccattta ttttcaaaac gtgaccaata tgtgttcacg taacgttcat
    10501 catcttccca gaagcttttc gtcataccta cccaaggttt ctctaagcat aattctccga
    10561 cttcatctcg aattggttta ccttgatcat ccagtacgac agctgccatt cctggtaaag
    10621 atgcgttaaa actaattggt gcgattggtt taataagaac attaccgaaa atcccaccag
    10681 agatttcagt tccacctgag tagttacaga ttggaacatt tcctttacca actgtttcaa
    10741 acagccacat ccatggatca ggattccaag gttctcctgt tgatgcgaat acttccaaac
    10801 tctttaaaga atgtttattg acatactcat caccttttgc cattaatgct cggattaacg
    10861 ttggcgaaat acctagatga gtaatttcat atttatcaac tgtctcccat aaccggtctg
    10921 cttctgggaa gtctggaaca ccttcgtaca taaccatcgt tgctccatta atgagtgaac
    10981 cgaataataa aaatggcccc atcatccaac ccatatcagt tacccataat acacgatcac
    11041 cttgtttaat attcattcca aatcctgcat caaaagctgc tttcaaagga aatcctgcat
    11101 gcgtgtgtac tgttcctttc ggcttaccag tcgttcctga tgtataaatg agcattaatg
    11161 gatcatcact ttgcatttcc tcggcatgta tgaatggttt ttctttttct agcgtactcc
    11221 acgaaaagtc atagttatgt ggtgtaaaat catttcctgc atgacgaacg ataacaactt
    11281 tttcaacagt tgggcaatgt tcacaagctt tatctacttc atcttttaaa gaaacaattt
    11341 taccgcggcg tgaaaatcca tctgcagtaa taatcatttt tgaacccgcc gcttgcacac
    11401 gtgtcataac tgcatcagac gcaaagcctg agaatattgg tgaaataatt gctccaattt
    11461 tcattacagc tagcatcgca acaactgttt ctggaatcat cggcatataa attgttacac
    11521 ggtcaccttt ttcaataccc gcgtgtttca aaccattggc aacacggctt acccagttat
    11581 caagctcttc atatgtaaat gattttgaag ttccattttc tccttcgtac tgaagtgctg
    11641 gctgtattct tgtctcttca tccgcaagcc agcgggataa agctgattct acaacgttac
    11701 atgttccgcc attataccac tgtgcaaacg gtgtaccatt ttctaaatct aacacctctg
    11761 tataaggttt catccattga tagccaactg ctttttctgc ctctccccaa agccaagctg
    11821 tttcttcaat agatttatta taaaaagttt catagtcttc atatcccaat gatttcatcc
    11881 aactatataa acgtgttttt tccttgtact cttctgttgg aaaccaaact gcttgtttca
    11941 atgttttccc ctccttaact ttttgagcaa gaaagcccta aatagggctt ttaaactgga
    12001 tatacaggat gtttacgatc cgtgaatact tgatatttac tcatatacat ttcgaaacgt
    12061 ccttttaact cttcacgtaa attgtttgga tgaacaatac catcaatcac catctctgat
    12121 gctaagtggt atatatcaat atctttctta tactcttcac gtttttcagc aataaagcta
    12181 gcacgctctt cttctggtaa agctgcaatt ttatttgcat atacagcatt gaccgcagct
    12241 tctggaccca ttaccgcaat agaggctgtc ggtaatgcca ggcagcaatc tggttcaaat
    12301 gctggacctg ccatcgcata taaaccagca ccatatgctt tacgaacaac gatagaaatc
    12361 ttcggtacag ttgcttcact cattgcagaa atcatttttg caccgtggcg aataatacca
    12421 gcacgctcta cttttgtacc gatcataaat cctggtacat ccgcaaggaa taataatgga
    12481 atatgatatg cgtcgcataa attaataaac ttagcagctt tatcagctga atcatggaat
    12541 aatacgccgc ccttcatacg cggctgattt gcaataatac caactggctt accatcaata
    12601 cgtgctaagc ctgtaattag ctcttgagca aataattttt ttacttcata gaatgaacct
    12661 tcatcaataa ctctattaat gagatctttc atattgaaag gagcattttg attttctgga
    12721 atgatttgtt ctaacgtttt atcgaattgt ttcggttctt gaggtgtaac caatggagtc
    12781 ttttctaagt agttatttgg aaaatatgaa atgtattgtc ttgcttgtgt aatcgcatct
    12841 tcttctgtct tacataaaac atctccgcat cctgatacag agcaatgcat acgagctccg
    12901 cccatttctt ctaaagttac cttctcaccg ataaccatct cagccatacg aggagatcct
    12961 aaatacatag atgcatttcc ttctaccatc attacaacgt cgcaaaaggc tggaatatag
    13021 gcaccaccag ctgcagaagg tccaaataat aagcatactt gaggaacttt acctgataat
    13081 ttcacttgat tatagaagat tctccctgca ccacggcgcc ctgggaacat ttctacttga
    13141 tctgtaatac gtgctccagc agagtcgact aaataaaata acggaacacg tagtttttca
    13201 gctgtttctt gaatacgtaa aatcttttca actgtgcgtg atccccacga tccagctttt
    13261 acagtagaat cattggccat tacacacgca gtacgaccat gtattttacc cgttgccgtt
    13321 acaacgccgt ccgcaggtaa gcctgtttgt tcacagttag caaataatgc atcttctaca
    13381 tattcgccat tatcaaatag aagcgctaaa cgatctcgaa caaataattt tccttttgct
    13441 ttattttgtt catgatattt tggtgcgccg ccttgtttaa tcgtttcaac tcgttcttca
    13501 aatgtatttg attgttgttt ttgatctaac atatttactc ccccttatac gttggtgtgc
    13561 gtttttcctt gaatgcttgt aatccttcta gtctatcttt cgtatggatt acaccttcat
    13621 acgcttgttt ttccatttgt aatccggtat gtaaatcaac ttgaataccg tttgaaatcg
    13681 ctttttttgc taatcgaaca gcaataggtc cattactagc aattttctct gctatttcaa
    13741 tcgctttctc ttcaagtaaa ttagctggta caacaaattc tactaaacca tattcttttg
    13801 cttcttgcgc tgaaatacgt ctacctgtat aaattaattc tttcgctcta ccaactccaa
    13861 ttaatctcgg taagcgctgt gtaccacctg ctcctggtat aattgcaagt gtcgtttcag
    13921 taagaccaag acttgtacat tcagcagcaa ttctaaaatc acaagctaaa cttaattccg
    13981 taccaccacc aagtgcgatt ccatttatag cagcaataac tggctgtggt aattgttcaa
    14041 ccatctccat agtagtgcga atcatactaa cagcatggcg aacttgttct tcattcatat
    14101 tggcacgctc ttttaaatct gcaccagcac aaaatgcttt ttcaccagca ccagtcaaaa
    14161 taactacacg cacgtttgaa tcttcactta tttgagttaa tatagtttgt aattcatcta
    14221 ataatgctaa agataatgag tttgcttgtc tttcacgata taacgaaatc tttacaacgt
    14281 gaggtgttac ataatcaact gaaatgtttt gtaattgtag catcttctca cctacttatc
    14341 gttttatgtt gaagcgctct atacacatga ctcggtaatt ggatatttaa tttactttga
    14401 ataaattgac ttgctctcaa taacttctct tcatcaatat tcgtttggac tcctaactta
    14461 tggagcatat gtactaggtc atcagtagca acattacctg atgctcctgg tgcataaggg
    14521 cagcccccga gtccaccaca agaactatca aacgttttaa taccgtattc taatgattta
    14581 actacattcg ctagagccat tccatacgta ttatgaaaat gcattgcaaa ctgcgaagca
    14641 tcatacttct ttaatagatg ttctaatact tgttctactt gtaatggatt cgctacaccg
    14701 attgtatccc caagagaaac ttcataaatg ccgtatgaaa atagttgatt acataattcg
    14761 tcaactgctg taacacttat atccccttca taaggacatc caaatacagt agaaacatag
    14821 cctcttacct tttttccttc gaataatgcc tgttttgtta tttcttcaat tacaactaat
    14881 gcttctttaa tcgatttatt aatattactt ttattatgag attcacttgc tgataaaaaa
    14941 acattcacct catctacatt ttgcaaaaaa gctcgttcca aaccattttg attcggaaca
    15001 agcgcagcat atgtaacatt tggatccctt ttcagctcag aaaatacatc atttgcatct
    15061 gctaatgcag ggacccattt tgggtgaacg aatgaggaaa cttcaacata cgacaatcct
    15121 gcttctgtaa gtagttgaat ccattttact ttatcttttg tgccaacaat ctttttttca
    15181 ttttgtaagc catcacgtgg cccgacttct ttaatgacag caaaattagg tagtttcaat
    15241 tcgcttcccc ctatatctcc ctattcaatt tctaataata catctccttc atttacaaaa
    15301 tcgccttctt gcacattaat tttcataact gtgccagctt cttctgaaat gattggaatt
    15361 tccattttca tagattccaa aatgacgaca tcctgctctt cctctactgt atctcctact
    15421 cctacaacaa tcttccaaac gtttcctgcc atcgatgcgt atactttcgt catcattttt
    15481 tcccccttaa tattgttaaa tcttattttt taacgagttg tttcgttaca aaacccgttg
    15541 tataaatacc ctctttgaac acttcgtctt ccaaaacttg cagtagcatt ggcgtgttcg
    15601 ttttaatacc ttctactttt aattcttcta gagcatcatg taatttcgaa attgcttctt
    15661 cacgagtctc gccatgtgca atgactttcg caatcattgg atcatagaaa ggtgtaatcg
    15721 ttacatgatt ttctaagaag tgatcaatcc gtacatttga cggtaatgtt aaatctgtaa
    15781 ttttcccagg tgatgggaag aatgttttcg gatcctctgc ataaatacga gcttcaatgg
    15841 catgaccact acattttaca tcatcctgag taaatgatag tttctctcca cttgcgataa
    15901 ggagttgctg ttctacaagg tctaatcccg taatttcttc tgtcactgga tgctctactt
    15961 gtaatctcgt attcatctct aagaaataga agttcttctg atcatctaca agaaactcaa
    16021 ctgtacctgc atttgtatag ccaagtgctt tggcagcttg tacagcaact tctcccatcg
    16081 cctttcgtgt accttcatct aaaaatggtg aaggtgcttc ttcgattact ttttgatttc
    16141 ggcgctgtac cgaacattca cgctcccata aatacactgt gttaccatgt gtatctgcta
    16201 aaagctgaat ttcaatatga tgcgcatctg ctatatatcg ctctaaatac atttctccgt
    16261 taccaaagaa gttttgcgct cttgttttat tactttcaaa cgctttggtg agcgtttgct
    16321 cagtttccat caactgcata ccaatgcctc cgccgcctgc ggatgcctta agcattaagg
    16381 gataaccaat ttgttttgca atttcaattg cttcttcagc agtttcaata tttgtagtaa
    16441 tacctgggac tactgggaca tctgctgctt gcattgcgat acgtgattcg attttacttc
    16501 ccatcttcgt aatgatttct tctgaaggac cgataaatac gattccttct tctttgcaac
    16561 gaaccggaaa agacggattc tctgataata aaccataacc cggatgaatc gcttctgcat
    16621 ttgtcttctt agctatttca ataatttttt caaggtttaa ataactttct tgaacacgcg
    16681 gtccacctac taagtaagct tcatttgcca tcttcacatg aagggcattt tcatctgctt
    16741 cagaataaat agcaacagtg cgtatgccaa gtttttgaca agttttcata atacgaacag
    16801 caatttcccc gcgattcgca attaatattt tttgaaacat agtgattcct cccttttatc
    16861 tacatcctaa atgtctagca attacgagac gttgaatttc agaagttcct tcaccaattt
    16921 ctaatagttt cgcatcacga atatgtcgtt caacttcata ttcacgcata taaccatatc
    16981 caccatgaat ctgtactgct tgattcgcaa tacggcttgc tgcttccgat gcaaatagtt
    17041 ttgccattgc cgcttctttg ccgaaaggtt tatcgttatc ttttaaccaa gctgctttat
    17101 gtactaaatt gcgtgctagc tctacttcag tcgccatatc agctaattta aattgaatcg
    17161 cttggaaatt agagattgac tttccaaatt gttgacgttc tttcgcatat tgtaatgcac
    17221 gttcaaaggc tgattgcgca ataccaactg ccaatgctgc gattgaaata cgccctccat
    17281 caagtgtata taaaaattgt ttaaaacctt tatttacatc accaagaata ttttctttcg
    17341 gtacacgcac accatcaagt acgatttcac aagtattaga agcacgaaca cccatcttat
    17401 cgtaaggact tgaaatcgtt aatccttcac tagtagtagg cacgataaat gcagaaatac
    17461 gttttctacc attctcttca acaccgttga cagcggttac aatgattgta tttgcatact
    17521 ctgcgtttgt aatccaacac ttctcaccac tgattacata ctcatcgcca tctaataccg
    17581 ctttcgtttg agtgccacct gcatcagatc cagcattcgg ctccgttaat ccgaaggcac
    17641 ctaatgtttt acctgacgcc attggaacta aatacttttg tttttgttct tctgtaccga
    17701 aataataaat tggagaagca cctaatgaaa ttgttgcagc atagcttaaa ccagtgccac
    17761 cacaagcgcg accaatttct tcaactgcta acgcatacga tactgtatcg ccacctgaac
    17821 ctccatactc ttctgggaat gggatgccta ataatcctag ttcgcccatt ttttgaaatg
    17881 tttcatatgg aaactctgca gttttgtcat aatatacagc tttcggtgcg atttcctttt
    17941 cagcaaagtc acgtaccatt tctttaatca tttgtttttc gcgagttaga gtaaattcca
    18001 ttccgctaca caccccttat cgaatattga gtttcgacag cgtgcgagtt tctactacaa
    18061 acataacaac ttaaaagaca agaatattag ttagacaatt gctacaattc tgtcataact
    18121 taattttaaa acagattctg tactaatgca caaaaaaatt cctacattgt tctacaacaa
    18181 cataggaggt tttgtgtcga attatgtaat ttattgttta ataatctcta ccttttccgg
    18241 aatcagaaat ttctactaat gcttcagggt atggttcgaa atatgtttgt cttaataaat
    18301 acttttcatc aaatcgaata gcccatgatt ttaaaattgt aagtaaacta ctaagtggta
    18361 ttttcttttc tgcatacttt tgtaacagtt ctataaaatg atctttttct tgttttttta
    18421 actttgtttt aaaatatcca aaaatgtgct cgcatacatt tacattcgat gtataacggg
    18481 gcgcacgcat aaataattca tataaagtct tctcatagtt ttcaaatacc acttcaatct
    18541 tttcattttt ttgatttgca attatacgcc ctaattcctt ttgtttcacc tgattatatg
    18601 ccataaataa atatttattg tccgactgaa acgatacaag gtcttttata tttttattat
    18661 gtttaatcat tttgtaatat gcgattgtaa atagccttgt aaagaaatgc tctctaataa
    18721 taaaattcga caatctgcct tcctcttcaa taggaagatg cgaaaatttt tttactactg
    18781 ctccgccaaa taagcccgat ccttttccct ttgctggcgc tttttcaaaa ccagaataaa
    18841 ttttcacatc acgcgtacca caacttggtg aacgattctt taaaataaaa ccatccacat
    18901 ccggtatcgt ttgtaaaaag tcatttgaaa actgctccat tttttcagtt acatcttctc
    18961 gtgtcgacgg ttgcacaact ctattctcac cattttcttc tacaattcgt atcgtttcac
    19021 gaggagtccc caatccaatc tcgacttctg gacaaacagg tataaatgta acaaatggct
    19081 gcaaatttcg tattgttaca tctggaatca tctctccatt ataacgacaa gcatcaaatt
    19141 ctaaacattt acttacgacg attgttggtt ttgcaaattg tcgcatctca ttacctcctt
    19201 agtgctagcc cgtataatat aaattgtact aagattaaca ttttaagcaa agtttgattc
    19261 atttattttt atgagaaata tatatccaat gatatattaa caatcattca actctatttt
    19321 ctataaatgt gcgccttatt aatgagggtt tagatattgt gaaatgaata atacacactt
    19381 gcttcggaga aattaatgat taagaaagga gggattgtta tgaaaaagaa attatcatct
    19441 attttaagtg ttttagcact atctattatg tttttaggta catctacgaa agctgaatac
    19501 gatggaaata atatgaatag agttaataac actgatattt caactcgagt aaatgacaat
    19561 aacttagaca gagttaataa tgatgtaaga actcgaaatg taaatacaac aaatgattta
    19621 aatgataatc gtgataaaaa taacaattgg gcttggcttg gtttattagg actagcagga
    19681 ttattaggtc ttagaagaag agacaaagaa acacgctgat ttagaatgtt tttagtaaac
    19741 aagtacttat ttatcaaaaa tatataatga aaataaatcg cctttttaaa ggcgatttat
    19801 ttttacttaa aagtaatgta tgtaattcac acttcaacga ttaaaatcgt ggagttaatc
    19861 catacaatat aaattgaatc gtattttcaa tttccgcttc atcattccat ttttcttcag
    19921 gcaataataa aaatcgtgtt aataataaac ctaatacagc tgataaagta agacgtagta
    19981 cggaagatgg tggtatctca ataatttccc cttcttcttg aaatttcaca atcaactttt
    20041 tgaaatgtga aaacagttct gtttctacta attgctgtat ttcatttttc agttctggtt
    20101 ggaatggcac ctcttgaatt aatattttta tcataggaaa gtgtttttga gcaaatttaa
    20161 acctattatg aattacaacc cttaaaagtc tttcatatga ttcatactcc gatttaaata
    20221 tttcttttgc aaaggtttgt acgaaaaatg gtgcagcgaa cttagttaaa gttggcatta
    20281 cgaccgctag taataaatct tttttcgtct tatagtagcg gaagattgtt ccttccgcta
    20341 caccagcccg ttttgcaatt tcacttgttg aagttgaagc gtatcctttt tctccaaaca
    20401 tatcaacagc cgcctctaat attcgcattt gacgttcatt tcttttatcc gtattagttg
    20461 cagctattaa ttcctccagc caatccttct gcatttataa agctcctttt tgtcattatt
    20521 atattttgcg atgtttcttt aaagcaaata catttcctac tgcaaataat attgaaaaaa
    20581 gtaataatac agtaagatct aatgcaatct ctgtaaaccc ttgattccga atcatcactt
    20641 gtctcattgc gtcagcgccg tatgtgagtg gaaatacttt ccctaacatt tgtagccact
    20701 tgttcataga ttccattgga aacaatccag aaaagaagat ttgtggcaca ataacaagcg
    20761 gtataaattg aatcatttga aattcattat ttgcgtatgc cgataaaaac gtacctaatg
    20821 ttagtgcagt taaagagagc atacatgtaa taagtagcgt tagccatata gagccagcta
    20881 cgtataaatc taaaatataa acggaaaaac ttacgataat aatggattgt ataaaggcaa
    20941 agattccaaa accaataata taacctgcga ctatttccca tcttcttact ggggtggata
    21001 ataacctttc tagcgtacca cttaaacgtt ctcttacgaa agatacacct gataatataa
    21061 atacaaagaa aaatgtaaag aaaccaatta atacaggacc aagcccatca aacatcgtaa
    21121 agtctttaga gccatgtaaa taatttactt caggtttcat aatcgataca tcattcttct
    21181 ctgtgctttt ttgcaatact tgaagtacag cacgattttt tgacgaatca ctaccttcca
    21241 acagaagttt catttttcca ttctctattt gaagtattgc atctatcttt tgtttttcca
    21301 actcagaaat cgccttttct ttactgtatt cataaattga cgcttcttga tttttcatca
    21361 cttttactat ttgagcgggc atatcaacaa cagcaatttg cggtatatag tctttctgtg
    21421 taaacactag tgataatagc caaagtaata acatcggtgc cccaaacatc attgctaacg
    21481 aacgcttatc tcgaaaaaat tgacgaataa tacgaatgat tacaccagta actctcatga
    21541 tggcaccacc tcttccagca aaaagacatc ttcaatccgt ccagatgaca cgcgtttttt
    21601 taattcttca gttgttccaa ccgcaactaa tttcccttct ctaattaacc ctagacgctc
    21661 acaaaattca gcttcatcca taatgtgcgt cgttacaata atcgttgtac ctttcttttt
    21721 aagatcataa aatttttccc aaatcgtttt tctaagaagc ggatctatcc ccactgtagg
    21781 ctcatctaaa attaatattt ctggttcatg gaggagtgct attgctaatg ataagcgttt
    21841 tttcattcca cctgaaaatt gttgtacttg ttttttcata tactgtgaca attgtacaag
    21901 ttcaaaaact tctgcgattc ttgtcttttt acgttttccc tttagtccat acatcgttgc
    21961 tataaaatct gcattttcat atgctgacaa ttcttcatat aatgcatccg cctgggccat
    22021 ataaccaatt cgtttcattt catttaaatt aggtatatta gtattattaa caagcacttc
    22081 acctttcgtt gcctcattaa tacctgcaat cattttaatg agcgttgttt tccccgatcc
    22141 agaaggtcca acaaaaccaa aaatctctgc tttttcaact tgcaatgaaa gattgtgtaa
    22201 cacttctttt tttccaaaac tttttgatac agtccgtaaa ataattgaag gttgttgcac
    22261 gtttcatcct ccttttccaa tgaaatgagt gagtactcac ttttatttta ctcttgctta
    22321 attatatgtc aaacttcgtt gattagtatg tatgttcaat caacgatatt aaacaatgaa
    22381 acagagtcga cattagaatt tcatttccta aagtcgactc tgtttcatta aaactataaa
    22441 tttcacttta cgtttttaaa ttcatatact tccgaattct agcaacgtct aaagaatatt
    22501 cgataactaa ttgctgtaac ggtaaaataa ctgtgtcagg atataaatgt gcatattgta
    22561 atgtttctgc atatttttct aacctttttt ctaaatactt tattatttga tcaggatgac
    22621 ttactaataa acatttacaa taataatgga tttgttcctc aatcgccgtg tattcttcaa
    22681 tttcatattc tttatgcatg tgtacacccc tttaagtttt ttacatgaat tacttatcac
    22741 aattttcact cgacaaattt taagtttttt gattatttac actataacaa acaatcaggg
    22801 tcaaattttg ttactttatg taacgtagaa aatttttaac aaaattgtaa tgtttactcc
    22861 tgcaaaatac agaaagcccc tttactcatt tttgtataaa aaaaaatcgt acagcttaat
    22921 ttagctgcac gactacaatt tctggcctat tcaaaatcct ttgcggaatg atactatttc
    22981 ctaatcctct actcactacc attgatgtat tttgttctac atataaaccc gctgtatatt
    23041 taggtaaaac accttgattt ggcgcaacta atcctccgat aaatggcaat ctaacttgcc
    23101 ctccatgagc atgtcccgat aaaaccaaat ccaacctctc attcgtatat tcctttataa
    23161 attcaggcct gtgggataat aatacattat atctatctgg ctgcatttca atttttgctt
    23221 ttttaatttc atctattata atatttcctt catcacggtt tccagtacca aactctggat
    23281 catcaatacc tagcaagttt atctcttgct caccctttcg aatgcctaca tgttcattcc
    23341 ttaaaacatt gacactatat ttcttcaact ctttttctaa actgttatac tttccagacc
    23401 attgttcatg gtttcctgtc acaaaatata caggatactt ctttaccatt tctcgtatta
    23461 attgcatact aacttctgca tcgtatgatt tactgtcaat taaatcaccc gtaattgcaa
    23521 taatatctgg gtctatactt ttcatttttt gaattaacac atcttgatta tcgccaaatt
    23581 ttttattgtg taagtctgaa atttgtagaa ttttataccc tttaaaagag gagggtattt
    23641 tactagaagt tattttaacc tcagttatac ttattaaatt gttctgtaaa tataaaaaga
    23701 ttgtaaaacc tactaatata caaataatca ttacgattct attaatcttt tttttcatat
    23761 tttctccttt atattctcat caaacacctc tatatgctaa ctgaattata ttataccttc
    23821 ttgaaattta tttaaattaa taaaataata cagtacatga aatttcatat gagatacgtc
    23881 atatatattc gttatatttt tacttttacc tttttaataa taagaataca aaaacgactc
    23941 ttatcacacg aaaagagtcg ttttctaact ttatactttt aatactttca tgttaaaaat
    24001 gcgaaaacta aaatactatt acctaagagc cttaactata acttcagttg cctctgcaat
    24061 gagttgatta tcataggttg cctctttctc atctttacta gataaaattg cgatgataat
    24121 tggtgctcta tttggaggcc aaacgatagc aatatcattt cttgtcccgt aactgccagc
    24181 acctgattta tctccaacta cccagtcagt tggtacgcct gcacgaataa gtttgtcccc
    24241 tgtagcattt cctttaatcc actctgtaag aattttacgt ttttcagctg gaagtgcatt
    24301 tccgaccgta aaagctttaa gattcgtagc aattgctttc gctgtactag tgtcacgaat
    24361 gtctcctgga atagcttcgt ttaattctgt ttcaaagcga tcagacatag taacccgatc
    24421 ccccatcttt ctaagcgctt tttcatatcc tttaggtccg cctattttat taaataaaat
    24481 gttccctgca gtattatcac ttgaacgaac agcagcctca gcaatttctc ctagtttcat
    24541 tccagtatct acatgtttct ctgtaacagg tgaataatcc actaagtctt ctttcgtaaa
    24601 tgtgattact tcatttaatg tatcaattga gttttgctgt agtaatactc ctgctgctaa
    24661 agccttgtag gttgatgcga aggcaaatct ttcgttagat cgataagaaa ttgtttgatt
    24721 tgtaccagta tcaatcgcat atacacctac tcgagcatca aattttttct caagttgaga
    24781 gaactcttta tgcgtcgcct gatttttatg tttcacttgt ccagtctttt ctttcgcttc
    24841 aacttgcagt gcccctcctg taaaagcttc taggcttgta atacttaaac ctaatatacc
    24901 aacgcatatt cctattttta gcatcctctt atttttcaaa atcatcattc cttccaaatt
    24961 tttagcacct ttttatacgt acacataata gacaatcacc gaaccaaatt tgttccataa
    25021 actaaaaaaa ttatagctag tatgagagtt attaacaaaa taagagatag tagctacgac
    25081 gcctctatct cctatttcat atttcatttt tttacttata aatggcttta tatgaacagg
    25141 ttctttccct gagaaaagta ctctaatttt gcttagaact acctgtacta gtagcttcac
    25201 catgtatacg ttgctgtttt aaatcaaagt atacatcta
//
