LOCUS       NZ_NKAX01000009        23507 bp    DNA     linear   CON 03-APR-2024
DEFINITION  Bacillus cereus strain 32-6 32-6_R1_(paired)_contig_9, whole genome
            shotgun sequence.
ACCESSION   NZ_NKAX01000009
VERSION     NZ_NKAX01000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus cereus
  ORGANISM  Bacillus cereus
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 337503)
  AUTHORS   Cui,Y.
  TITLE     Improper usage of probiotics constitutes a potential risk of public
            health
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 337503)
  AUTHORS   Cui,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUN-2017) Beijing Advanced Innovation Center for Food
            Nutrition and Human Health, College of Veterinary Medicine, China
            Agricultural University, Yuanmingyuan West Road, Beijing 100193,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC NGS Cell v. 9.5.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009935145.1-RS_2024_04_03
            Annotation Date                   :: 04/03/2024 04:19:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,979
            CDSs (total)                      :: 5,895
            Genes (coding)                    :: 5,727
            CDSs (with protein)               :: 5,727
            Genes (RNA)                       :: 84
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 76
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 168
            CDSs (without protein)            :: 168
            Pseudo Genes (ambiguous residues) :: 0 of 168
            Pseudo Genes (frameshifted)       :: 62 of 168
            Pseudo Genes (incomplete)         :: 100 of 168
            Pseudo Genes (internal stop)      :: 56 of 168
            Pseudo Genes (multiple problems)  :: 40 of 168
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:34
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 51803
            Orig. end                         :: 75310
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NKAX01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23507
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23507
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23507
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13507](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13507)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            549..1232
                     /locus_tag="CE086_RS08225"
     CDS             549..1232
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001128607.1"
                     /locus_tag="CE086_RS08225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YukJ family protein"
                     /protein_id="WP_161519988.1"
                     /transl_table=11
                     /translation="MPLKNYGVLKGTVIQSKIGKGKTPHYQVHLQGETGVDYRIAINVK
                     SQSYPSEVLYFASNNIRSEAIHILPTLPFGFTEVKNNEPKVALDYVRGNLFDSKQMIPL
                     PPEKAGADNDLNEKIERYIKRAMEEKAIIYAFGERWGPEENTPDSYFHFKPGNGIHDIH
                     MNQGNVEKWKGDNGIWQDGGILIHFEKEEEWIGIFLAFQSQSWCTDEEGHARVRVEHCD
                     YKRSN"
     misc_feature    1264..1278
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.62"
                     /tool="antismash"
     misc_feature    complement(1310..1322)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            1397..1936
                     /locus_tag="CE086_RS08230"
     CDS             1397..1936
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002186397.1"
                     /locus_tag="CE086_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_063546863.1"
                     /transl_table=11
                     /translation="MKITEENVVKQIKKRNEKSITFIIQTYGGLLSAIIKKYVQSNQQD
                     YEECLDDVLLAIWFHIDSFDSSKNTFKQWIAAIAKYRAIDYQRKNVRNQQQTVCTEIND
                     RLYQEQRKQNDFLDVQELLSELSATDRNIFEKYYLEGVPSREIASHLNVKESWIHNKLS
                     RGRKKLKQIFIFKNGV"
     gene            1941..2912
                     /locus_tag="CE086_RS08235"
     CDS             1941..2912
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029762.1"
                     /locus_tag="CE086_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4179 domain-containing protein"
                     /protein_id="WP_063546865.1"
                     /transl_table=11
                     /translation="MSIYKELNDIQLDITEFEETPLTKLEEKQWEKRVKNKLRKNKHSK
                     KWFGVAAACMLIVSITVPLGQTSLANMPFIAGLIEKYIDKQQPLDYSPYKTAIGKTAEN
                     KYGKLTLNEVLVDENKLFISSTFEPAKGVKFDYQTYLIPQVRINGRDFSNAKDAQSIGV
                     NDSMFTIYGGVELSEMPQTDELQIEITYDTFNKDTVIEQPWIFDIEVSQAQLMKEKQTF
                     DLNETIALYDGNKVIVKKVVSTPISTTIYYDVPQSANEDIYFKIESESGKTYIFKEAFV
                     SNKGGDISFSRFDGINVAAGKYSLVPYSGKENEVIGPSIPIQ"
     gene            complement(2958..3791)
                     /locus_tag="CE086_RS08240"
     CDS             complement(2958..3791)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017762920.1"
                     /locus_tag="CE086_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000424522.1"
                     /transl_table=11
                     /translation="MELVNSIFQILLTSVIQLLSLIGVIIVIGFLLGYLESLTRMYWSR
                     AFGRKGFLLTAWIGVPIHELGHAIMCVLFRHKIVATQFFPTDTSQGALGYIQHQYNQKS
                     VYQRIGNFFIGIGPIISGITALILLMRYFVPESYFLFNTTLEKTIASTSINVEMIQNML
                     LSTFVLLKSLFTIGNLLNPSFWLFLFIAICISAHIALSKPDIKGSIDGVVVMFIVLFLF
                     NIIAGLFQYDSNQLIGQVMKYNMYLIAFSSVALLFSCLSTLVSFSFYKIRRGRSF"
     gene            3988..4773
                     /locus_tag="CE086_RS08245"
     CDS             3988..4773
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000650096.1"
                     /locus_tag="CE086_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_161519989.1"
                     /transl_table=11
                     /translation="MKCPSCHTENAVEAKFCGNCGHSLTEEVVASSGQEEGLEQARAAQ
                     AKEARPNETVEQAKRFASGYFQFFKHALQAPTAIMKSGAIEVRNGIVSLVLICFLGACI
                     FYRMMSAASAVTRTFAPDISTPTFFGESITVFFFLLILTLFVGFIIFVSGKMMKSSFSF
                     LEVFGIWGTIATPAIVILVLSFLFSFLLIFFLPILLSVVATYIGISITVAVLKLDNGGL
                     DLVYTLIIANVLIGIATFIVLWSYISTIIQALTQGITGF"
     gene            4793..6028
                     /locus_tag="CE086_RS08250"
     CDS             4793..6028
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017672808.1"
                     /locus_tag="CE086_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YARHG domain-containing protein"
                     /protein_id="WP_161519990.1"
                     /transl_table=11
                     /translation="MNVCTKCGIQFEDGVQFCQNCGTKRGRPVVKKNMSGGAKVGITLL
                     ALFVIVIIGLYLYGSSYYTQVAQVDRMITILQERDGEKLAEIVTADDPSVMITRESITP
                     LFSYIKENPSYVNELKEYLRQGEKQWDGIERTDFSLTKDGKYFFIFDRYKLKVKTYYTT
                     LLTNEKGVSLKMNGKEIDKTDDKKFEKQYGPFLPGNQVFQSEYKNDYVKLSREEKVVLM
                     KQSQNNVTIDLTLQGQYITVQTNAPGATLYVNQKPVTALVGEEITWGPVATDGSATIYL
                     ERNGESGRETTQVETVTALSSYNLSFQKKSTEKTVVYNVTPPPTTGYVYNGFIFPDSDI
                     RKLTSADLTYLSKEQLKIARNEIYARHGHIFQTKDMQVYFAKQSWYRENPYFKGTLTDI
                     ETYNIELIKSRE"
     gene            complement(6075..6506)
                     /locus_tag="CE086_RS08255"
     CDS             complement(6075..6506)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000332402.1"
                     /locus_tag="CE086_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000332407.1"
                     /transl_table=11
                     /translation="MCAGLLAQLPDEPQEPKEPKPAVSLDQEFSINATIYSARAWLSND
                     DTFAQDIWKATQFASASHAGKSIFPVGSVKIINFSDDTITVTASPESDHALKIVVPPHS
                     EAALTSGPLSHIQASTSGGSSKVTFLFHIFFSRDPGPAK"
     gene            6704..8038
                     /locus_tag="CE086_RS08260"
     CDS             6704..8038
                     /EC_number="1.8.1.14"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001110220.1"
                     /locus_tag="CE086_RS08260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CoA-disulfide reductase"
                     /protein_id="WP_098032984.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.4e-66, bitscore:
                     218.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYVIIGGDAAGMSAAMQIVRNDENANVVTLEKGEIYSYAQCGLP
                     YVISGAIASTEKLIARNVKTFREKYGIDAKVRHEVTKVDTEKKMVYAEHTKTKDVFEFP
                     YDRLLIATGVRPVMPEWEGRELQGVHLLKTIPDAERILKTLETNKVEDVTIIGGGAIGL
                     EMAETFVELGKKVRMIERNDHIGTIYDADMAEYIHKEADKHNIEILTNENVKAFKGNER
                     VEAIETDKGTYKADLILVSVGVKPNTDFLEGTNIRKNHKGAIEVNAYMQTNVQDVYAAG
                     DCATHYHVIKEIHDHIPLGTTANKQGRLAGLNMLDKRRAFKGTLGTGIIKFMDLTLART
                     GLNEKEAKGLHIPYKTVKVDSTNMAGYYPNAKRLYLKLLYRSDTKQLLGGQVIGEEGVD
                     KRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQAARRAE"
     gene            8138..8626
                     /locus_tag="CE086_RS08265"
     CDS             8138..8626
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002135035.1"
                     /locus_tag="CE086_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_098032983.1"
                     /transl_table=11
                     /translation="MIVALQKVQESEKEILRNLYALYLHDLSKFTMNITIGANGFFEYE
                     DLHMFWKNDGITPYFIKVDHSIVGFLLLLERPFLKKENDFGINDIFILNQYKGKGIGKQ
                     AVENLLEEKRGQYFVIELLKNVPAVSFWKNVYKKLNIEFDEKEQLIDDEECLVQTFKI"
     gene            8878..9288
                     /locus_tag="CE086_RS08270"
     CDS             8878..9288
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996799.1"
                     /locus_tag="CE086_RS08270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3908 family protein"
                     /protein_id="WP_098032982.1"
                     /transl_table=11
                     /translation="MAINMKTIEEWIVESNTRHEEDFGHVVEEMKEVCVGLDNATLIYT
                     KNVFCFGKKVEVFFFFQDHVVIGQEKDEYIEIEKLKYDDIINNNLKTNDKNTTLELKFA
                     NGQSINLDSLNDNYGTKNWLFARQIKSIFKLI"
     gene            complement(9318..9908)
                     /locus_tag="CE086_RS08275"
     CDS             complement(9318..9908)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (49-149). E-value: 2.4e-10. Score:
                     31.0. Matches aSDomain: nrpspksdomains_CE086_RS08275_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016109564.1"
                     /locus_tag="CE086_RS08275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_098032981.1"
                     /transl_table=11
                     /translation="MNILQRLIQQAKKPRGTIGSSMLCIMNAAHMRLTNWGLQKIHIRK
                     DAITLDIGCGGGKTIHTLSKRIPFGKIYGIDYSDQAVENSKKANIQDVKKGKVIIHQAS
                     VSSIPYNTNFFDLITAFQTHYFWPDVEQDIKEIFRVLQPNGSFLLVAETFKIQYHMEKW
                     KTNEELINLFYKTGFTSVKCYEERGCLCVIGIK"
     aSDomain        complement(9462..9761)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CE086_RS08275_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.40E-10"
                     /label="CE086_RS08275_oMT.1"
                     /locus_tag="CE086_RS08275"
                     /protein_end="149"
                     /protein_start="49"
                     /score="31.0"
                     /tool="antismash"
                     /translation="LDIGCGGGKTIHTLSKRIPFGKIYGIDYSDQAVENSKKANIQDVK
                     KGKVIIHQASVSSIPYNTNFFDLITAFQTHYFWPDVEQDIKEIFRVLQPNGSFLL"
     gene            complement(10001..11542)
                     /locus_tag="CE086_RS08280"
     CDS             complement(10001..11542)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016124293.1"
                     /locus_tag="CE086_RS08280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_078993533.1"
                     /sec_met_domain="PF00881 (E-value: 5.1e-10, bitscore: 34.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLDTFLHHLHFSIDEIMPNHEVDWKDAPLPYKLYRNVPTIPLSL
                     EIPLSLSNSSTTPTLNEIGHYLWYSFGVTQLCQLNSERNVLRRSIPSGGALYPNELYIY
                     LKIDDYPDGIYHYDAAHHRLILLREGNFDSYLADALGNRCNIHDCFGAAFVSTMFWKNF
                     FKYNNFSYRLQGLDSGVLIGQLLECAKQFGYTNGVYFQFLDRALNHLLGLSEGEESVYA
                     VIPLSTEPETNWFHNDYRENKTVTSHELLQQIPPLAHEHFVRSKHVNEHPMITKINEAS
                     MIESTEHFQTLHHEEHYQHNTYAVQLPKVERLSYDFLQLCKKRYSPDADFILTKWDAAE
                     LATLLQEASLSFPYYSDLDGKYVNENARVSLYGCFYNVKDIENGAYTYNSKTHSIQPLR
                     YGDLRYLLQSSMTMDNVNLFQVPLCLHVVGKKDYYTRALGYRGYRIHQMEAGILVHKLV
                     FAATAMGMGGHPLLSFDTNSCDQLYGIDAGNETSLIQIPVGAYRARDWLKGALHN"
     gene            complement(11558..13507)
                     /locus_tag="CE086_RS08285"
     CDS             complement(11558..13507)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191877.1"
                     /locus_tag="CE086_RS08285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_071730668.1"
                     /sec_met_domain="YcaO (E-value: 3.3e-85, bitscore: 281.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2e-144, bitscore:
                     475.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRNILLIGDGLLADYVHDQLCEQYSIIRQHTITEELPENIHLAL
                     VLHDGSPSTIHHDAELIFRSNHIPWLRGFTSFGEGIIGPYIHPLSSGCSHCSDGRRFIA
                     GFDQQEMWELQRKYAFKADNVTRRDVRATQNGMLQMCHLIRVETEKILTHNHSSLENEL
                     ILLNLQTLQCTRHSFLPDPLCPICSNLPDDTADAAELSLQPSLKVSTETYRCRSIHELN
                     TFLTRDYLDYRVGMLNGKMQHSLLPFADVIINMPLMFGNEGVAGRTHSFAVSEATAILE
                     GLERYCGMSPRGKKTNVHGSFHDLEEHALNPLTLGVHTNEHYNRDNFPFKPFDPDYEQN
                     WVWGYSLSQNRPLLVPESIAYYSLGHRDAFVYETSNGCAIGGSLEEAIFHGILEIVERD
                     AFLLTWYAELPLPRLDLSSANDTELQLMIQRLRTITGYELHAFNATMEHGIPSLWVIAK
                     NTRENGMNVVCAGGAHLDPIRALKSAIQEIAGMLLITDDELEHKREYYEKCLQDPYFVN
                     KMEDHSMLYGLKETEERLHFLLREDAPVQTFQEMNVSQSFDMDLTSDLHQLLNRLHQSN
                     LEIIVVDQTVPLIEKNGLHCVKVIIPGMLPMTFGHHLTRVTGLDRVYTVPMTLGYSTEP
                     LTNEQLNPHPHPFP"
     gene            complement(13504..15423)
                     /locus_tag="CE086_RS08290"
     CDS             complement(13504..15423)
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513905.1"
                     /locus_tag="CE086_RS08290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_001061546.1"
                     /sec_met_domain="TIGR03693 (E-value: 0.0, bitscore: 1219.0,
                     seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     4.3e-56, bitscore: 181.5, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 2.9e-12,
                     bitscore: 41.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPIHAKLKVNKDTFFLPDSNGGVYFRNNASSFRMDGAGIYDW
                     IEKLMPMFNGNYSLAEITDGLPLPYQNRVFEIGEILYENGFVRDTNQDEPHELNSTLLD
                     RYASQIEFLEADSHSGALKFETYRGANVLVLGSGDMLTSLVSSLLESGLPTFHYLVTDR
                     DETNYDRIHELIERAYEVDNTVLLQEIDTTIDRPLHEVFEPFDWILYVSQNGDIDGLKT
                     VHTICREAKKNFIPAICLSTLGIAGPVVTENRDECWESAWHRLHETTLQNENSSDSFSP
                     ITSAMLANVIVFELFKHVADDSHREKGSQFFLLNYETLEGTWHPFIKHPLATDESFTID
                     TIENLSEKLEHRSNQHTSTDVFQFFDSLTSKEAGIFHVWDEQDSYQLPLSQCYIQVANP
                     LSDGPAPLLPLMTCSGLTHNEARREAGLTGIETYVAEIIHRLIPEHNDIGIGAGETMTE
                     GFYRALQQHLNNKLYERQSHTLEELTTIDLTDIHDKHCRFYYDALSTIHETPTIAMSEE
                     ILSFPVVWIGINDRWYGASNINMTLALRNALQLALFHIQNEEIPYRANILYDSSIILYD
                     TDSFRVEIQPEEEIPNVQSLQLALQHLEEHNFYPFVFDLAIEPFLKENLDGVYGVLIAK
                     EDGL"
     aSDomain        complement(15124..15423)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CE086_RS08290_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="3.30E-57"
                     /identifier="RREFam011.1"
                     /label="CE086_RS08290"
                     /locus_tag="CE086_RS08290"
                     /protein_end="100"
                     /protein_start="0"
                     /score="181.5"
                     /tool="antismash"
                     /translation="MNNLPIHAKLKVNKDTFFLPDSNGGVYFRNNASSFRMDGAGIYDW
                     IEKLMPMFNGNYSLAEITDGLPLPYQNRVFEIGEILYENGFVRDTNQDEPHELNS"
     aSDomain        complement(15157..15393)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CE086_RS08290_Thiopeptide_F_RRE.1"
                     /evalue="2.20E-13"
                     /identifier="RREFam004.1"
                     /label="CE086_RS08290"
                     /locus_tag="CE086_RS08290"
                     /protein_end="89"
                     /protein_start="10"
                     /score="41.0"
                     /tool="antismash"
                     /translation="KVNKDTFFLPDSNGGVYFRNNASSFRMDGAGIYDWIEKLMPMFNG
                     NYSLAEITDGLPLPYQNRVFEIGEILYENGFVRD"
     gene            complement(15548..16807)
                     /gene="odhB"
                     /locus_tag="CE086_RS08295"
     CDS             complement(15548..16807)
                     /EC_number="2.3.1.61"
                     /GO_component="GO:0045252 - oxoglutarate dehydrogenase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004149 - dihydrolipoyllysine-residue
                     succinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="odhB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716916.1"
                     /locus_tag="CE086_RS08295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-oxoglutarate dehydrogenase complex
                     dihydrolipoyllysine-residue succinyltransferase"
                     /protein_id="WP_000569892.1"
                     /transl_table=11
                     /translation="MIEIKVPELAESITEGTISQWLINVGDKVEKGGSVVELETDKVNV
                     EIIAEDSGIVSKLLGEPGDTVEVGATIAILDANGAPVAVSTPAPAAEQPKQETAEAPKA
                     AAPNAEQTTGLQGLPNTNRPIASPAARKMARELGIDLNDVRSTDPLGRVRPHDVQAHAA
                     APKEAPAAPKSPAPAPVAKTEFEKPVERVKMSRRRQTIAKRLVEVQQTSAMLTTFNEVD
                     MSAIMELRKERKDAFEKKHDVRLGFMSFFTKAVVAALKQFPLLNAEIQGDELIIKKFYD
                     IGIAVAAPDGLVVPVVRDANQLNFAEIESEIRNLGMKARDNKLSLKELQGGTFTITNGG
                     VFGSLMSTPILNSPQVGILGMHKIQVRPVAIDAERMENRPMMYLALSYDHRIVDGKEAV
                     SFLVAVKDMLEDPKSLLLEG"
     gene            complement(16940..19807)
                     /gene="odhA"
                     /locus_tag="CE086_RS08300"
     CDS             complement(16940..19807)
                     /EC_number="1.2.4.2"
                     /codon_start=1
                     /gene="odhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000197121.1"
                     /locus_tag="CE086_RS08300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-oxoglutarate dehydrogenase E1 component"
                     /protein_id="WP_161519991.1"
                     /transl_table=11
                     /translation="MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFE
                     IFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVEQIRSFGHTLAHINPMEDAA
                     NGQSLLEKAMSGLSDADLKAIPAKTVWQDAPEGIHTALDVIHRLKDVYTKSLAYEFSHI
                     QDSEERAWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGV
                     DMLVPVLDEIVLEGAKNGVEDVMIGMAHRGRLSVLAHVLEKPYTHMFAEFKHAKIEGAV
                     ANAGWTGDVKYHLGREQVVSNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSG
                     LPEQDTSKSFVILVHGDAAFPGQGIVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSY
                     DSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRTLFKKDFLIDLIGYRRYG
                     HNEMDDPAVTQPQVYKKIKNHPTVRAIYADQLQAAGVLNADEIETITQFTQEQLKSDYA
                     QVPPADTSDATIHVKVPDVVAKGIQPIDTGVELDSLRAINEGLLSWPEGFNVYPKVKKI
                     LERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTETN
                     ETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQA
                     LFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSA
                     AQYFHILRRQASILGTEAVRPLVLMTPKSLLRHPLTLSTASQLSEGRFQPALEQENLGT
                     KPNKVKRLVLSTGKMAIDLAAEIESGKHEYNLDEVHVVRIEQLYPFPAEKVQSIIKRFK
                     NLEEIIWVQEEPRNMGAWHYMAPILFELAGDKVKTGYIGRPDRSSPSGGDPFAHKAEQE
                     LIVAHALDVKYNFRQDKLEIEVFSN"
     gene            20631..20840
                     /locus_tag="CE086_RS08305"
     CDS             20631..20840
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428510.1"
                     /locus_tag="CE086_RS08305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000428506.1"
                     /transl_table=11
                     /translation="MENKMVEYRKKFGLSQEKLAEKLGVSRQTIISIEKGKYDPSLPLA
                     FEIAKTFQTTIEHVFIYEGKEEGE"
     gene            20843..21220
                     /locus_tag="CE086_RS08310"
     CDS             20843..21220
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016101524.1"
                     /locus_tag="CE086_RS08310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048564894.1"
                     /transl_table=11
                     /translation="MNYSQKYFVIMGVIFLFMSGFMILTGIMTHSAPPAITYPLLGMMI
                     MSFCLSYLHPQFKEKDERMKLIRYKGMFVTFFALTAYYLLFSIGLNLKILTLSATELLN
                     ILMALTMSTVFISFVVLAKRY"
     gene            21249..21431
                     /locus_tag="CE086_RS08315"
     CDS             21249..21431
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002086895.1"
                     /locus_tag="CE086_RS08315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3976 domain-containing protein"
                     /protein_id="WP_001178303.1"
                     /transl_table=11
                     /translation="MQMMYAFGIGLVLFLAVFLFIRKDVQGGTLTKRGFYKMIGCLVVM
                     FIAIIVMIVLISRSL"
     gene            21578..21926
                     /locus_tag="CE086_RS08320"
                     /pseudo=""
     CDS             21578..21926
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034134.1"
                     /locus_tag="CE086_RS08320"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFYLLTCLLLVASTAYYNM"
     gene            21955..22206
                     /locus_tag="CE086_RS08325"
     CDS             21955..22206
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002126037.1"
                     /locus_tag="CE086_RS08325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_140157268.1"
                     /transl_table=11
                     /translation="MSYPWVLRKTFFLCFILSPIGAACILMNRGAIQKRDFILYLLFAA
                     MNISLWLLLMIFDWSMWMVVGHYLFGAVVIVFSNMNKS"
     gene            22294..>22437
                     /locus_tag="CE086_RS08330"
                     /pseudo=""
     CDS             22294..>22437
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016718550.1"
                     /locus_tag="CE086_RS08330"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="WXG100 family type VII secretion target"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKVTPERLEQTAKTVNNIRHFLEYLHNDLYNQIKNIAIQWNGASR
                     EQF"
ORIGIN
        1 cactctcgca aacgatcaaa caatggattc cttttgctat tactacgaca atgtttatcg
       61 ccatttcaga attaatgggt gcatcaggca tgcatttatt actcgcaaag acagctggtg
      121 aaacatttgg aacctttttc gttttcgttg cgccgtttat tggtgctatt ggtggatttt
      181 taacaggtag taacgcagga tcaaatgcaa tgtttataaa actacaaatg caaaccgcac
      241 aaaacgtagc actcccgtgg caatacgtca caacactgca aaacactgca tcatcagtag
      301 cgacaatcgc ttgcccgtca cggattacac taggtgcgta cttatgtaat ataccgtatc
      361 gtgaaaatga actattaaag aagacgacgt taatgatttt gggtgcaatt ttgctcgtag
      421 tagtagaggt tattgtttgg tatatgttga gaaattaaaa accctcctaa cataggagga
      481 ttttttttat gagtggataa tgatttaaat atgaatagct tctactaaat gaataggaga
      541 tgaaatgtat gcccctaaaa aactacggtg tgttaaaagg tacagttata caatcaaaga
      601 ttggaaaagg gaaaacacct cattatcaag ttcatttaca gggcgagact ggagtagatt
      661 atcgtattgc tattaacgta aagtcgcaaa gttatccgtc agaagtttta tattttgcga
      721 gtaacaatat taggtcagag gcgattcata ttttaccgac attaccattt ggttttacgg
      781 aagtaaaaaa taatgaaccg aaagtagctt tagattatgt aagaggaaat ctatttgact
      841 caaaacaaat gattcctttg cctcccgaaa aagcaggagc agataatgat ttaaacgaaa
      901 aaatagaacg ttatataaag cgagcgatgg aagaaaaagc aattatttac gcgtttggcg
      961 aaagatgggg accagaagaa aatacaccag attcctattt tcatttcaaa ccaggaaacg
     1021 gtatacatga tattcacatg aatcaaggga atgtagagaa atggaaagga gataatggta
     1081 tatggcaaga cggaggaata ctcattcact ttgaaaagga agaagaatgg attggtatct
     1141 ttcttgcctt ccaatcacag tcatggtgta ccgatgaaga ggggcatgct cgtgttcggg
     1201 ttgaacattg tgattataag agaagtaatt aaagggaaga gctagttcgt aatgaactag
     1261 ctcttctcat tatgaacaag atatatgttg tttaatggtg aaattgtgtt tgcaatatga
     1321 aaaacagtga tagggttatt gtttttcatt cgtattagaa agtagatacc aattagcagt
     1381 acaaggaggt ctacctttga agataacgga agaaaatgtt gtaaaacaaa ttaaaaaacg
     1441 taatgagaaa agcattacgt ttattattca aacatatgga ggattactca gcgctattat
     1501 taaaaaatat gtacagagca atcagcaaga ttatgaagaa tgcttagatg atgtattatt
     1561 agcgatttgg tttcatatcg attcatttga ttcaagtaaa aatacgttta aacaatggat
     1621 agcagccatt gcaaaatatc gggcaattga ttatcagcgg aaaaatgtga gaaatcagca
     1681 acaaactgtc tgtacggaga ttaatgatcg tctgtatcaa gaacaaagaa aacaaaatga
     1741 cttcttagac gtacaggaac tgcttagtga gttgtcagca acagatcgta acatttttga
     1801 aaagtattat ttagaaggtg taccgtctcg tgaaattgca tcccatctta acgtgaagga
     1861 gtcatggatt cataacaaac tgtcacgcgg acgaaaaaag ctcaaacaga tttttatttt
     1921 taaaaatgga gtgtgagggc atgtctattt ataaagagtt aaatgatatt cagttggata
     1981 tcacagagtt tgaggagact cccttaacca aactagagga aaagcagtgg gaaaaacgtg
     2041 tgaaaaataa gctccgtaaa aacaaacatt caaaaaaatg gttcggagtc gcagcagctt
     2101 gcatgctaat tgtcagcatt acagtgccgc ttggacaaac atctttagca aatatgccat
     2161 ttatagcggg attaattgaa aaatatattg ataaacagca accacttgac tattctccct
     2221 ataaaacggc tattgggaaa accgctgaaa ataaatacgg taaactgact ttaaatgagg
     2281 tactagtgga tgaaaataaa ttatttatca gttcaacatt tgagccagcg aaaggtgtga
     2341 aatttgatta ccaaacatat ttaattccac aggtacgaat aaatgggcgt gacttttcta
     2401 atgcaaagga tgcacaatca attggagtaa atgattctat gtttacaatt tacggtggtg
     2461 ttgagttaag tgaaatgcca caaactgatg aacttcaaat cgaaattact tatgatacat
     2521 tcaacaagga tactgtaatt gagcaaccat ggatatttga tatagaagta tcacaagctc
     2581 agttgatgaa agagaagcag acgtttgatt taaatgaaac aattgcttta tacgatggca
     2641 ataaagtaat tgttaaaaaa gtagtttcta cgccgatttc cacaacaatt tattatgatg
     2701 tgccacaaag tgcaaatgaa gatatttatt ttaaaatcga atcagaatct ggaaaaacat
     2761 atatatttaa agaggcattt gtatcgaata aaggcggaga catttctttt agtagatttg
     2821 atggaattaa tgtagcggcg ggaaaatatt cacttgtacc gtattcgggg aaagaaaacg
     2881 aagtgattgg accatctatt cccattcaat aacttattaa atctgataaa taattattta
     2941 aagatagaag agggcgttca aaaagaacgc cctcttctta ttttataaaa cgaaaaacta
     3001 acgagtgtag aaagacaaga gaacagcaat gccacactag aaaacgcaat gagatacata
     3061 ttatatttca taacctgtcc aattagctga ttactgtcgt attgaaacag tcctgctatt
     3121 atgttgaata aaaataacac gataaacatg acgacaacac cgtctattga tcctttaatg
     3181 tctggtttac ttaaagcgat atgtgcggaa atgcaaatgg cgataaataa aaataaccaa
     3241 aaggaaggat tcaataaatt gccgattgta aataagcttt tcaataatac aaacgtcgac
     3301 aagagcatgt tttgaatcat ttctacatta atagaagtag aagcaatcgt tttttcgaga
     3361 gttgtattaa ataaaaaata tgattctggt acgaaatagc gcattaaaag gattaatgca
     3421 gtaataccag aaataatagg cccaatgccg ataaagaaat tcccaattcg ttgatacaca
     3481 cttttttgat tgtattgatg ttgtatataa cctaaagccc cttgacttgt atctgttggg
     3541 aagaactgag tcgccacaat tttatgacgg aacagtacgc acataatggc atgtccaagt
     3601 tcgtgaatcg gaacaccgat ccaagccgtt aataggaatc cttttcttcc aaaagctctc
     3661 gaccaataca tgcgtgtgag agattctaaa tagcctaata gaaatccaat tacaatgata
     3721 acgccaatta aagataataa ttggattacg cttgtaagga gtatttgaaa aattgagttt
     3781 accaattcca ttttctttca tccaatctgt taaaaatatt atttattctg tttcataata
     3841 gcattttttt tcaagattgc tagcacatat attttctttc ggaagaagga tttcagaatc
     3901 tttttcttgt agtcatgttt tatgtacaaa ttcatatatt gaacttgtaa caccctataa
     3961 ggtatatgct taaggaggga taagagaatg aaatgtccgt catgtcatac agaaaatgca
     4021 gtagaggcaa agttttgcgg gaattgtgga cattcgttaa cggaagaagt agtggcaagt
     4081 agtggccaag aagaagggct ggaacaagca cgtgcggcac aagcaaagga agctcggcca
     4141 aatgaaacgg tagagcaagc gaagcggttt gcgagcggct attttcaatt ttttaaacat
     4201 gcattacaag caccgacagc gattatgaaa agcggcgcta ttgaagtgcg aaatggaatt
     4261 gtaagtcttg ttcttatttg ttttttagga gcatgtattt tttatagaat gatgagtgca
     4321 gcatcagcag ttacgagaac atttgcacca gatatatcta ctcccacgtt ttttggagaa
     4381 tctataacgg tctttttctt tttattaatt ttaactttat ttgtcggatt tattattttt
     4441 gtaagtggta agatgatgaa atcatctttt tcatttcttg aagtatttgg tatatgggga
     4501 acgatagcga cgccggctat tgtcatatta gtcctttctt ttctttttag tttcttatta
     4561 atctttttct taccgatatt attatcggta gttgcaactt atataggcat tagtataact
     4621 gtagccgtat taaagctaga caatggcgga ttagatctcg tttacacact tattattgca
     4681 aatgttttaa ttggaattgc aacattcatt gtactttggt cttacattag cacgataatt
     4741 caagccttaa cacagggaat aactggcttc taatgaaaag gtggttgact ggatgaatgt
     4801 atgtacaaag tgcggaattc agtttgaaga tggtgtgcaa ttttgtcaaa actgcgggac
     4861 gaagagggga cgtcctgtag taaagaagaa catgagcggt ggtgcaaaag ttggcattac
     4921 actgttagca ctatttgtta tagtgattat tggattgtat ttgtacggat cgtcgtatta
     4981 tacgcaggta gcacaagtag accggatgat tacgatttta caagagcggg acggagagaa
     5041 attagctgag atcgttacgg cagatgatcc atcggttatg ataacgagag agagtataac
     5101 gcctctattt tcatatataa aagaaaatcc atcatacgtg aatgaattaa aagaatattt
     5161 gagacaaggt gaaaaacaat gggacggaat agaaagaact gatttttcat taacgaaaga
     5221 cggaaagtat ttctttatat ttgatcggta taaattgaaa gtgaagacgt actatacaac
     5281 tttgcttaca aatgaaaaag gcgtatcgtt aaaaatgaac ggaaaagaaa ttgataagac
     5341 agatgacaaa aagtttgaga agcaatatgg gccatttctt ccaggtaatc aagtatttca
     5401 atcagaatat aaaaatgact atgtaaaact atcgcgtgag gaaaaggttg tacttatgaa
     5461 acaaagccaa aataacgtaa cgatagattt gacgctgcaa ggtcaatata ttacagttca
     5521 aacgaacgcg cctggtgcaa cattgtacgt aaatcaaaaa ccggttacag cgctggtagg
     5581 agaagaaatt acatgggggc cagtagcgac tgatggaagt gcgacgattt atttagaacg
     5641 aaatggagaa agcggacgag aaacgacaca agtagagacg gtaacggcac tttcgtctta
     5701 taatctttca ttccaaaaga aaagtacaga aaaaacagtt gtttataatg ttaccccgcc
     5761 acctacgact gggtatgtat ataatggttt catctttcct gatagtgata ttcgaaaatt
     5821 aacgagcgca gatttaacat atttatcgaa agagcagttg aaaattgcta gaaatgaaat
     5881 atatgcaagg catggacata tttttcaaac gaaagatatg caagtgtatt ttgcaaaaca
     5941 gtcttggtat agagaaaatc cttattttaa aggaacgtta acagatattg aaacttataa
     6001 tattgaacta atcaaatcaa gagaatagag cacttgaaaa aggtacagtg tatattgctg
     6061 taccttttct atcgttattt agctggacca ggatcccttg agaaaaagat atgaaagaga
     6121 aatgtgactt tacttgatcc tcctgatgta ctagcttgta tatgtgataa aggaccagac
     6181 gttagagcag cctcggaatg gggtggtacg actattttga gcgcatgatc tgattctggt
     6241 gaagcagtaa cagtaattgt atcatcagag aagtttataa ttttaacaga accgactgga
     6301 aagatggact tgccagcatg tgatgctgaa gcgaattggg tagctttcca aatatcttgc
     6361 gcaaacgtat catcgttaga taaccaagca cgagcgctat atattgttgc attaatggaa
     6421 aattcttggt caagtgagac ggcgggtttc ggttcttttg gttcttgcgg ttcatctgga
     6481 agctgggcga gaaggccggc gcacatacat ttcacctact ttcaatagta actgttatag
     6541 catattaaac attttgttta taagacacga cagttaccta ttcatacata agtttgtgca
     6601 ccaaatttga agatgaaatt ctctttcttt acaatggaag taggtgttat ttctataaaa
     6661 tatggaaaac gtaaagagta tgtaaaaaag aaggagtggt aaagtgaact atgtcattat
     6721 tggcggagat gcagctggta tgagtgcagc tatgcaaatt gttagaaacg atgaaaatgc
     6781 aaatgttgta actttagaaa aaggtgaaat ttattcatac gctcagtgtg gattaccgta
     6841 tgtcattagt ggtgctatcg cttcaactga aaagttaatc gcgcgcaatg taaagacgtt
     6901 tcgtgagaaa tatggaattg atgcgaaagt gcgtcatgaa gtaacgaaag tagatacgga
     6961 aaagaaaatg gtgtacgcag agcatacgaa gacgaaggat gtctttgaat ttccatatga
     7021 tcgattatta attgcgactg gagtacgtcc tgttatgcca gaatgggaag gaagggaatt
     7081 acaaggcgtt catcttttaa aaacaattcc ggatgctgag cgcatattaa aaacgttaga
     7141 aacgaataaa gttgaagatg taaccattat tggcggcggt gcgattggac tggagatggc
     7201 agaaacattc gtcgaacttg gtaagaaagt aagaatgatt gagcgaaatg atcatatcgg
     7261 tacgatttat gatgcagata tggctgaata tatacataaa gaagcagata aacacaatat
     7321 tgaaatttta acgaatgaaa atgtaaaagc atttaaagga aatgaacgag tagaagcaat
     7381 cgaaacggat aaaggtacgt ataaagcaga tcttatttta gtgtcggttg gagtgaagcc
     7441 aaatactgat tttcttgaag ggacaaatat acgtaagaat cataaaggag caatcgaagt
     7501 aaatgcatat atgcaaacga atgtacaaga cgtatatgca gccggtgatt gcgcaacaca
     7561 ttaccacgtt ataaaggaaa ttcatgatca tatcccgctc ggaacgactg ccaataaaca
     7621 agggcgactt gctggactaa atatgcttga taaacgaaga gcatttaaag gtacgttagg
     7681 tacaggcatt attaaattta tggatttgac actcgcaaga acaggattaa atgaaaaaga
     7741 agcaaaaggg ctacatatcc cgtataaaac ggtcaaagta gattctacaa atatggcggg
     7801 ctattatcca aatgcaaaac gactttactt gaaattacta tatcgctccg atacgaaaca
     7861 attgttgggc ggacaagtaa ttggagaaga aggcgtagat aaacgtattg atgtgattgc
     7921 aatggcgctt ttcaataaaa tgagcattca tgatttagaa gatgtcgact taagttacgc
     7981 accaccatat aacagtgttt gggatccaat tcagcaagcg gcaaggagag cggaatagca
     8041 ctttttaaag tgctattttt ttgttaaagg ggaattatca tttttttcga atgaagaggg
     8101 ttgggaaata gttacatatg aggaaggaga gttttttatg attgtagcac ttcaaaaagt
     8161 tcaagaatca gaaaaagaaa tattacgtaa tctgtacgct ttatatcttc atgacctttc
     8221 taagttcact atgaatataa ctataggagc gaacggattt tttgaatacg aagatttgca
     8281 tatgttttgg aaaaatgacg gaatcacgcc gtattttata aaagttgatc atagtattgt
     8341 aggattctta ttactactgg aacgtccgtt tttgaagaag gaaaatgatt ttggtattaa
     8401 tgatattttc atattgaatc aatataaagg aaaaggaatc ggtaaacaag ctgttgagaa
     8461 tttactagaa gagaaaagag gacaatattt cgttatcgaa cttctaaaaa atgtaccagc
     8521 agtgtcgttt tggaagaacg tatataaaaa actgaacatt gaatttgatg agaaagagca
     8581 gttaattgat gatgaagaat gtctcgttca aacgtttaaa atttaatgaa attggtgttc
     8641 cttttatatt actttgaaat ttaactttat cccgctattt gcggacagta agacccccac
     8701 ctcaaaatcc agtgaaagca aagaagttag gtgggggatc aagaaaaacc ccactgatta
     8761 aagtttcact ttattttgaa tataccgttc ccccttgaaa acatattact aatcgcttat
     8821 attttcatat agtatttatt ttttaaacga agcaatgaac gaaccagggg gcacagtatg
     8881 gcaattaata tgaaaacaat cgaagaatgg attgttgaat caaatacaag acatgaagaa
     8941 gactttggac acgttgtgga agaaatgaaa gaagtatgtg tcggacttga taacgcgaca
     9001 ttaatttata cgaaaaatgt attttgtttc ggtaaaaaag tagaagtatt tttcttcttc
     9061 caagaccatg tcgtgattgg acaagaaaaa gacgaatata ttgagattga aaaattaaag
     9121 tatgatgaca ttataaataa taatttaaaa acaaatgaca aaaatacaac gttagaatta
     9181 aagtttgcta acggacaatc tattaattta gatagtttaa atgataacta cggtacgaaa
     9241 aattggttat ttgctagaca aattaagagt atttttaagt taatctagta aaaagcagac
     9301 ctcaaagggt ctgcttttta cttaattcct attacacaaa ggcaacctct ttcttcatag
     9361 catttcacac ttgtaaatcc tgttttataa aataggttta ttaattcttc attcgttttc
     9421 catttctcca tatgatattg aattttgaaa gtttcagcta ctaataaaaa agatccattc
     9481 ggttgtaaga cgcgaaatat ttcttttata tcttgttcca catcgggcca aaagtagtgt
     9541 gtttgaaaag cggttatgag atcgaagaag tttgtattgt aaggaataga ggagacactt
     9601 gcctgatgaa tgattacttt tccttttttt acgtcctgta tattggcttt ctttgagttt
     9661 tcaacagctt gatctgaata atcaattcca tatattttcc caaatggaat tcgttttgaa
     9721 agagtatgta ttgttttgcc gccgccacaa ccaatatcta aagtaattgc atctttacgt
     9781 atatgtattt tttgtaatcc ccaatttgtt agtctcatat gtgcagcgtt cataatacaa
     9841 agcatggaag aaccaattgt cccgcgaggt ttttttgctt gctgaattaa tcgttgtaaa
     9901 atgttcaagt tacattctcc ttttatgtaa gaatatatac tcatttcgct ttttataaat
     9961 taagtccttt aaaaaaagca cgccgtctac cggcgtgctt ctaattatgc aaagcccctt
    10021 ttaaccaatc ccgcgcccga tacgccccaa caggaatttg aatgagagac gtttcatttc
    10081 cagcatcaat tccgtacaat tgatcacatg aatttgtatc aaaacttagt aaaggatgcc
    10141 cgcccatccc catagcagtt gcagcaaaaa cgagtttatg aacgaggata ccagcttcca
    10201 tttggtgaat acggtatcct ctatagccta atgcacgtgt atagtaatct ttctttccga
    10261 ctacatgtaa gcaaagtggt acttgaaaaa ggtttacgtt atccatcgtc atactagatt
    10321 gaaggagata acgaaggtcc ccatatcgaa gtggttgtat ggaatgtgtt ttactgttat
    10381 aagtgtaagc accgttttct atatctttta cgttatagaa acatccatat aatgagacgc
    10441 gtgcattttc atttacatac ttaccatcaa ggtcgctgta ataggggaag gagaggctcg
    10501 cttcttgtaa taaagtagcg agctcagctg catcccattt cgttaaaata aagtccgcat
    10561 caggagaata tcgtttttta caaagttgta ggaaatcata cgataaccgt tctactttag
    10621 gtagctgtac agcgtacgta ttatgttgat agtgctcttc atgatgtagt gtttggaagt
    10681 gttctgtcga ttcaatcata gaagcttcat ttatttttgt tatcatcgga tgttcattta
    10741 catgttttga gcgaacgaaa tgttcatgtg ctaacggcgg aatttgttgc aacaactcat
    10801 gagaagtaac tgttttattt tcacggtaat cattgtgaaa ccaattagtt tctggctctg
    10861 tacttaaagg aataacggca tacacacttt cttcaccttc tgacaatccg agtaaatggt
    10921 tcagtgcacg gtctagaaat tgaaagtata cgccgttcgt ataaccgaac tgttttgcac
    10981 attctagtaa ttgtccaatg agaaccccgc tatctaatcc ttgaaggcga tatgaaaaat
    11041 tattgtattt aaagaagttt ttccaaaaca tagtggatac gaatgcggca ccgaaacaat
    11101 catgtatatt acagcgatta ccgagtgcgt ctgctaaata agaatcgaaa tttccttcgc
    11161 gaagtaaaat aagtcggtga tgcgcggcgt cataatggta aatgccgtct ggataatcgt
    11221 caatctttaa atagatatac aattcattcg gatataaagc accgcctgaa ggaatggatc
    11281 tgcgtaatac atttctctcg ctatttagct gacataattg tgttacacca aatgaatacc
    11341 aaaggtagtg accaatctca tttagagtag gtgtagtaga agagttcgat aaagataacg
    11401 ggatttctaa ggagagcggg atggtaggta catttcgata taatttataa ggaagcggtg
    11461 cgtctttcca gtccacctca tgattcggca taatttcatc aatagagaaa tggagatgat
    11521 gtaaaaaagt atctagctgc atgaaatccc tcctttacta tggaaacggg tgcggatgtg
    11581 gatttaattg ttcatttgtt aacggttcag tgctatatcc aagtgtcatc ggtacggtat
    11641 agactctatc taatcctgta acacgagtaa ggtgatggcc gaatgtcatc ggtaacatgc
    11701 ctggaataat gacttttaca cagtgtagtc cgttcttttc tataagggga acggtttgat
    11761 ctacaacgat tatttcaaga ttagattgat gcaaacgatt taaaagttgg tggagatcgg
    11821 atgttaaatc catatcaaat gattgtgata cattcatttc ttggaacgtt tgtaccggtg
    11881 catcttctcg taaaaggaag tgaagacgtt cttccgtttc tttcaatccg tacagcatac
    11941 tgtggtcttc cattttatta acgaaataag gatcttgtaa gcatttttca tagtattctc
    12001 ttttgtgctc gagctcatcg tctgttataa gtaacatgcc tgcgatttct tgaatggcac
    12061 tttttaaagc tcgaatagga tctaaatgag cgcctcccgc acaaacaacg ttcattccat
    12121 tttcacgtgt attttttgca attacccata agctcgggat gccgtgttcc atcgtcgcat
    12181 taaaagcgtg taattcatat ccggtaatcg tacgtaaccg ctgaatcatt aattgtaatt
    12241 ctgtatcatt tgctgaactc agatcaaggc ggggaagagg taattcggca taccaagtga
    12301 gtaagaaggc atcacgctct acaatttcta aaatgccgtg aaaaatcgct tcttctaaac
    12361 taccgccaat tgcacatcca tttgatgttt catacacgaa agcatctcga tgaccgaggc
    12421 tataataagc aattgattca ggaactaaaa gcggtctgtt ttgtgataaa gaatatcccc
    12481 atacccagtt ttgctcataa tcaggatcaa acggcttaaa tggaaaatta tcacgattgt
    12541 aatgttcatt tgtatgtaca ccgagtgtga ggggatttag tgcatgttcc tctaaatcat
    12601 gaaaactacc atgcacattt gtctttttcc cgcgaggcga cataccgcaa tatcgttcta
    12661 aaccttctaa aatagcagtt gcttcactca ctgcaaatga atgagttcgg cctgcaacac
    12721 cttcatttcc aaacattaat ggcatgttta taatgacgtc agcgaatggc aataaagaat
    12781 gctgcatttt gccgttcaac ataccgaccc gataatctaa atagtctcgc gttaaaaatg
    12841 tgtttaattc atgaatggaa cggcagcgat acgtttcggt gcttactttt aaactcggtt
    12901 gtaaagaaag ttccgccgca tccgcagtat catcaggtaa attactacat ataggacaga
    12961 gaggatctgg aagaaaagaa tgccgcgtac attgtaatgt ttgtaagttg agtaaaataa
    13021 gttcattttc taaagaagaa tggttatgag ttaatatttt ctctgtttct acgcgaataa
    13081 gatggcacat ttgtaacatt ccattttggg tggcgcgtac atcacgcctc gttacattgt
    13141 cggctttaaa ggcgtatttc cgctgtagtt cccacatttc ttgttgatcg aagccagcga
    13201 taaatcggcg tccatcagaa caatgagaac agccagatga aagaggatga atgtaaggac
    13261 cgataatacc ttcgccaaat gaagtgaaac cgcgaagcca cggaatatga tttgagcgaa
    13321 aaataagttc agcatcatga tgaatagtag aaggagatcc gtcatgtaat acgagagcga
    13381 ggtgaatatt ttcagggagt tcttctgtaa tggtatgttg gcgaatgatg gaatattgtt
    13441 cgcataattg atcatgtaca tagtctgcaa gtaggccatc tcctataagc aatatatttc
    13501 gagtcataga ccatcctcct ttgcaattaa taccccatac acaccgtcta agttttcttt
    13561 caaaaatggt tcgattgcta aatcaaacac gaaaggataa aaattatgtt cttctaaatg
    13621 ctgtaaggca agctgtaaag attgcacatt tggaatttct tcttctggtt gtatttccac
    13681 tctaaaagaa tcagtgtcat ataaaataat agatgagtca tacaaaatat tagctctgta
    13741 aggaatctct tcattttgaa tgtgaaagag tgccagttgt agtgcgtttc gtaacgctaa
    13801 cgtcatattt atattagatg caccgtacca tctatcattt ataccaatcc aaacgacagg
    13861 aaaactaaga atctcttcac tcattgctat tgtaggtgtt tcatggattg tagagagagc
    13921 atcgtaataa aatctacaat gcttatcgtg aatgtcagtt aaatcaattg ttgtaagttc
    13981 ttctagcgta tgtgactgcc gttcatacag tttattgttt aaatgttgtt gtagtgcgcg
    14041 gtaaaaacct tctgtcatcg tttctccagc accgataccg atatcgttat gttcaggaat
    14101 aaggcggtga atgatttctg ctacatatgt ttcaattcct gttaaaccag cttctcggcg
    14161 tgcctcatta tgggtcaatc cactgcaagt cataagaggc aggaggggag ctgggccatc
    14221 tgatagtgga ttggctactt gaatatagca ttgtgataac ggtaattgat atgaatcttg
    14281 ttcatcccat acatggaata taccggcttc tttagaagtt aatgaatcga aaaattggaa
    14341 tacatcagtt gaagtatgtt ggttagaccg atgctcaagt ttttcagaaa gattctctat
    14401 cgtatcaatt gtaaaacttt catcagttgc aagagggtgt tttataaaag gatgccacgt
    14461 tccttcgagt gtttcatagt ttaataaaaa gaattgtgat cctttttccc gatgtgaatc
    14521 atccgcgaca tgcttaaata attcaaaaac gattacattt gctaacattg cagatgtaat
    14581 gggtgagaag gaatcagatg aattttcatt ttgcaaagtc gtttcatgta gacgatgcca
    14641 tgcagattcc cagcattcat cacgattttc cgttacgaca ggtccagcta taccgagtgt
    14701 tgataaacaa atagctggta tgaaattctt tttcgcttct ctacaaatag tgtgaactgt
    14761 ctttaaaccg tcaatgtctc cattttgaga aacatataaa atccaatcaa aaggttcgaa
    14821 tacttcatgc aaaggacggt caattgtagt atcgatttct tgaaggagta cagtgttatc
    14881 aacttcatat gcacgttcta ttagctcatg tattctgtca tagtttgttt catcccgatc
    14941 tgtaacgagg taatgaaatg taggtaaacc agattctaat aaagaagaaa ctaaggaagt
    15001 aagcatatcc ccagaaccaa gtacaaggac atttgcccca cggtacgttt cgaattttaa
    15061 agcacccgaa tgagaatcag cttctaaaaa ttcaatttgt gaagcatatc tgtcgagtaa
    15121 tgtactgttt aattcatgag gttcatcttg atttgtatcg cgaacgaaac cattttcata
    15181 taaaatctct ccaatttcaa atacgcgatt ttgatagggg agagggagac catcggttat
    15241 ttctgctaaa gaataattcc cgttaaacat tggcattagt ttttcaatcc agtcataaat
    15301 tccagcaccg tccatgcgaa atgaactggc gttatttcga aaatagacac ccccgtttga
    15361 gtcggggagg aagaaagtat ccttatttac tttaagtttt gcatgaattg gaaggttatt
    15421 cattttaatc ctccttacgt ttaggcatac attattactt tatgtcatga aatttgtccc
    15481 gtatgaacaa aataaaaaaa ggctgtagaa tgattcattc tacagccttt aataggttaa
    15541 aaatctatca accttctaat aataatgatt ttggatcttc aagcatatct ttaacagcaa
    15601 caaggaagct aactgcttct ttaccatcaa caatacggtg atcgtaagat agtgcaaggt
    15661 acatcatcgg acggttttcc atacgttctg catcaattgc aactgggcgt acttgaattt
    15721 tatgcattcc taaaatacct acttgtgggc tatttaggat tggtgttgac attagagaac
    15781 cgaatacacc accgtttgta attgtaaatg taccaccttg tagttctttt aatgaaagtt
    15841 tgttatcgcg tgctttcata cctaaattac gaatttcact ttcgatttca gcgaagttta
    15901 attggttagc atcgcgtaca actggaacaa ctaatccatc tggagctgct actgcaatac
    15961 cgatatcata gaattttttg atgataagct cgtcaccttg aatttcagca tttaataatg
    16021 ggaattgttt taatgctgca acaactgctt ttgtgaagaa tgacatgaag ccaagacgta
    16081 catcatgttt tttctcgaaa gcatctttgc gttctttacg taattccatg atcgcactca
    16141 tatcaacttc gttaaatgtt gttaacattg cagatgtttg ttgaacttct acaagacgtt
    16201 ttgcaattgt ttgacggcgg cgggacattt tcacacgctc aactggtttt tcgaattcag
    16261 tttttgcaac tggagcagga gctggactct ttggagcagc tggtgcttct tttggtgctg
    16321 cagcatgagc ttgtacatca tgtggtctca cgcgtccaag tggatctgtg ctacgtacgt
    16381 cgtttaagtc gattcctaat tcacgagcca tttttctagc agctggtgat gcaataggac
    16441 ggttcgtatt tggtaagcct tgtagacccg tagtttgttc agcatttgga gctgcagctt
    16501 tcggtgcttc agctgtttct tgttttggtt gctcagcagc tggagcaggt gtacttactg
    16561 caactggtgc tccattagca tctaaaattg cgatagttgc gccaacttca actgtatccc
    16621 caggttcgcc tagtaacttc gatacaatac ctgaatcttc tgcaatgatt tctacattga
    16681 ctttatcagt ttcaagctca acaacgctgc cacctttctc aactttgtcg cctacgttga
    16741 taagccattg tgaaatagtt ccttcggtaa tagattctgc aagctcaggt actttaattt
    16801 cgatcatttt aaatgtcctc cccttatttg cctaacggtg tgttttttct tcttttgtct
    16861 tcggtaatct ccatttgtta gcctgaccct gggcagaata tctgcccggg atcaagctag
    16921 aaaccgtcat tgttactttt taattgctga aaacttcaat ttctagttta tcttgacgga
    16981 agttatactt cacatctaaa gcgtgtgcaa caattagttc ttgctcagct ttgtgagcga
    17041 atggatcgcc gccagatggg ctagagcgat ctgggcgtcc aatgtaaccc gttttcactt
    17101 tatctccagc tagttcgaac agaattggag ccatgtaatg ccatgcgccc atattacgag
    17161 gttcttcttg aacccaaata atttcttcta agtttttaaa gcgtttaata atagattgaa
    17221 ctttctcagc agggaatggg tacaactgct caatgcgaac gacatgaacc tcatctaagt
    17281 tgtactcatg tttaccagac tcaatttctg ctgctaagtc aatcgccatt ttacctgtac
    17341 ttaaaacaag acgttttact ttgtttggtt ttgtgccaag gttttcttgt tctaaagcag
    17401 gttggaaacg tccttcgctt aactgactag cagttgaaag cgtaagtggg tgacgtaata
    17461 aactctttgg cgtcatcagt actaatggtc gaacagcttc ggttcctaag atagatgctt
    17521 gacgacgtaa aatatggaag tattgtgccg cgctcgttaa gtttgcaact gtccagttgt
    17581 tctcagcagc taactgtaag aaacgttcag gacgtgcact agagtgctct ggtccttgac
    17641 cttcataacc gtgtggtaat agaagaacta aaccagattt ttgaccccat tttgctcttc
    17701 cagctgaaac atattgatca aataatgctt gcgcagtatt tgagaagtca ccatattgcg
    17761 cttcccacat aacaagagtt tctggagcga atacgttata accatactcg taaccaacaa
    17821 cagcagcctc tgataacgga ctgttatgaa cagagaatga agcattaatg tttggtaaac
    17881 ggtgtaacgg tgaatatgtt tcatttgttt ctgtatcgtg cagtacgata tgacggtgtg
    17941 cgaatgtacc acgctgtgaa tcttgaccag ttaaacgaat tggcgtacct tcttgtaaaa
    18001 tagaagcgaa tgctaacgat tcagcaagtg cccattcaat tttaccgttc tcttcaagag
    18061 catctttacg gcgctcaaga attttcttca ctttcggata tacgttaaag ccttctggcc
    18121 aagataatag accttcatta attgcacgaa gtgagtcaag ctcaacacca gtatcaattg
    18181 gctgaatacc ttttgcaaca acatctggca ctttaacgtg aattgttgca tcgctcgtat
    18241 cagctggtgg tacttgtgca tagtcagatt ttaattgctc ttgtgtaaac tgtgtaattg
    18301 tttcaatttc atctgcattt agaacaccag cagcttgtaa ttgatctgca taaattgctc
    18361 ttacagttgg gtgattttta atctttttgt acacttgtgg ttgtgtaact gctgggtcat
    18421 ccatttcgtt atgaccatag cgacggtaac caattaaatc gattaagaaa tcttttttga
    18481 acaatgtacg atattgaatt gcaaggtttg cagcagcaag acaagcttct ggatcatcag
    18541 cgttcacgtg aacaatcgga atatcgaaac cttttgcaag gtcacttgaa tatttcgtag
    18601 aacgagaatc atagctgtca gttgtaaaac caactgcatt gtttgcgata acatgaatcg
    18661 ttccgcctgt ttggtacgca ttcaatctgc ttaagttcaa cgtttcagat acaatacctt
    18721 gaccagggaa tgcagcatca ccatgaacta aaattacgaa tgattttgaa gtatcttgtt
    18781 ctggaagacc agatttttta cgattctctt gagctgcacg tgcgaaacct tctactacag
    18841 gattcacgaa ctcaagatga ctcgggttat ttgctaaagt aacgcgagtg ctaacttctt
    18901 cattactaac gacttgttct ctacctaagt ggtatttcac gtcgccagtc cagccagcat
    18961 tggctactgc gccttctatt tttgcatgtt tgaattcagc aaacatgtga gtatatggtt
    19021 tttctaatac gtgagcaagt acgcttaggc gaccgcggtg agccatacca atcatgacat
    19081 cctctacgcc gttcttagca ccttctagaa caatttcatc taaaacaggt acaagcatat
    19141 caacgccctc gatagagaaa cgtttttgcc caacgaatgt tttatgcaag aattgctcga
    19201 aaccttcaac agctgttaaa cgttttaaaa gagcagttcg ttttttattt gatagtggtt
    19261 gacgcaatga atttgattcc accatttgat gcaaccacgc gcgttcttca ctatcttgta
    19321 tatgagaaaa ttcataagct aaagattttg tataaacgtc ttttaatcta tgaattacat
    19381 caagtgcagt gtgaatacct tctggtgcat cttgccatac tgttttcgct ggaatcgctt
    19441 tcaagtcagc atcgctcagt ccactcattg ctttctcaag aagtgattgt ccatttgcag
    19501 catcttccat cgggttaatg tgagccaacg tgtgcccgaa agaacgaatt tgctcaacaa
    19561 gttgaacgac tttaagaatt ttttcaatgt tacctgtgtt ttgaggagaa aaatgtgttg
    19621 ctgtgttgtc ccctgttacg acatcatctt gaaacgaagg agctccaaaa atttcaaaaa
    19681 gctcttgtaa ttccggatca acagaacctg ctccagttac gtaaagatca tactgctcaa
    19741 taacataacc aaggttcgga ccgtggaact tggcccaagg gtttgtcgtt gtattcttcc
    19801 tcgtcatttg tttaaacctc ccaatgcata taatcctttt ccatacaaag gtgcattttg
    19861 ctctttttca ataagtaatg aatcaataat caatgtaaat gttttcttta ctcttatgtt
    19921 attacaataa tttacataat accaaacact attacttatc tgttttgtaa aaaaacattc
    19981 acaataactt atcacccaag ttaatctttc actttataaa gtaattttac agaaaaatgg
    20041 ggtggatata tttggtatgc ctatactaat agctataatt gttgcattta aatataggta
    20101 taatagttag aatgttttga taaaatttag tttgaattat gtatattgaa ataataagcg
    20161 ctttcataga tattatacaa caatataacg gaatatagta taaaaaataa aaaattatga
    20221 atttatcgta aactttattt cgatagtgtt aaatatcgaa aggaaaatga aggatttcca
    20281 caaaaaaagt ggctaaacat aaaaattgct tcataacccg ttagtttcta taaatatgcc
    20341 aaaaaacacc gtaaaaccaa taacgcattt catctaataa agaagagaat gaaatatttt
    20401 aaaaggataa aacaaatatg aagatattaa attttaaaaa aggtgaggag gaaatatagt
    20461 aacgattaca tacagtgttc caggttttat tacaaaatag acgtgttgaa atcgaacaag
    20521 tttcttctat ataaatagag tgaaaaatga ttaaaaggaa tgtaaaggaa ccttgacgta
    20581 aagtttactt tacatatata ctcgatatat gggaggaggg agaaatttcc ttggaaaata
    20641 aaatggtcga ataccgaaaa aaatttggac tatctcaaga aaaattagct gagaaacttg
    20701 gcgtttcaag acaaaccatt atctcaattg aaaaaggaaa atacgatccg tcacttccgt
    20761 tagcatttga aatagcaaaa acatttcaaa caacgataga acatgtattt atttatgaag
    20821 gaaaagaaga gggggaatag ggatgaatta ttcacaaaag tactttgtaa ttatgggtgt
    20881 tatttttcta tttatgagtg gatttatgat attaacaggt ataatgacgc attctgcacc
    20941 accagctata acgtatccat tgcttgggat gatgattatg agtttctgcc taagctactt
    21001 gcatccgcaa tttaaagaaa aagacgagcg aatgaaactt attcgttata aaggaatgtt
    21061 tgtaaccttt tttgcattaa cagcatatta tcttcttttc tctatcggct taaacttaaa
    21121 aatacttaca ctatctgcta ctgaattatt gaatatactt atggcactta caatgagtac
    21181 cgtctttatc tcatttgttg ttttggcaaa aagatattaa gatggaagag agaaaggaag
    21241 attaatatat gcaaatgatg tatgcttttg gcattgggct tgtattattt ttagctgtat
    21301 tcttatttat tcgtaaagac gttcaaggcg ggacgttaac gaaacgagga ttttataaaa
    21361 tgatcggctg tttagttgtt atgtttattg cgattattgt aatgattgtt ttaataagtc
    21421 ggtcactata gaatgtaaaa aaggaacctt acttcggtaa ggtttttctt tattgttcaa
    21481 cctgaaaatt accgctaaat ccatttatta taaataactt atattatata atccaatgaa
    21541 atgatagata aggagtgtag tatatgaata aaaaactatc ttctatttat taacttgtct
    21601 actacttgta gctagtactg cttattataa tatgtaacaa acgagaacaa gtgccaccta
    21661 tattagtatg tgaggatcag gagtaccacg taacgaatga acctgccaaa gtagaagaag
    21721 ttgggcaaaa acttggtgaa gtaacaaaaa aaattaaaac aagtaaaaaa cctattaaaa
    21781 atagagaatc taatacatta caagagaaaa cagaagtatt cacaatgatt gaggaagaaa
    21841 aagatcctca atcaccttta atcataaagg aaacttatag tgatgaatat agggtagtga
    21901 ggccgatgtt gaagcaggta ttgtgatgaa aaggagaatc ttttgtagac agtaatttcg
    21961 tatccgtggg tgttaagaaa aacttttttc ctttgtttta ttttgtcccc tatcggtgcc
    22021 gcttgcattt tgatgaatag aggagcaata caaaagagag atttcatttt atatttatta
    22081 tttgctgcta tgaatatatc actttggtta ttgcttatga tttttgattg gagtatgtgg
    22141 atggtagtag ggcattattt gtttggagca gttgttattg ttttttcgaa tatgaataag
    22201 agctaagcca gcaaccttaa agttgctggt ttttattttg ctatttataa tgaagaaaca
    22261 aataaatcaa tatgtaaaga aggaatggta tagataaaag taacgcctga acggttagaa
    22321 cagactgcaa agacagtaaa taacatcagg cacttcttag aatacttaca taatgactta
    22381 tacaatcaaa ttaagaatat cgctatacaa tggaatggag cgagtagaga acaattttaa
    22441 cagagattta acgaagtaaa accaaaaatg tttaatgttt taatagaagt taaaaactac
    22501 aatgtttatt aatgaanntt cattaataaa cattgtagta aaacagttgg aagatagatt
    22561 gaaatatttg cccgaaggtt cacatcagac tgtcgtgata gatgtgagag gaccagatgg
    22621 aacgagagaa acattgaagt aaataagaga agaaataaat caaagaacat ttggacaggc
    22681 agaaattatc attaaaaaga tacaaaaaag taggttatat tacagagtta gcacaaatgc
    22741 ataagttata atttcaagtg ccataaggat aaccctgagg agaaaaaaga cttctgattt
    22801 ttaagattat ataaaatatt catagttgca aaaactctat tgtggtaaaa tattctatat
    22861 aaatatttaa aaggggaatg gctatggggg atataaaagt tactcctgaa cagttgcgaa
    22921 aagtggcagg gactattaga tcaactatca cgaatgcaac tgcaacacag gagcgactaa
    22981 aacgagatat tgatatgatt tctagtaatt ggttgggctc aacctatatg aaatttaata
    23041 cggatttccg tgattcatcc tttaagatgg cacaatttat aatcatattg gagccacttg
    23101 agaagtttct tcttgattct gctaataaat ttgaacaagt agataacatg gatgttgcta
    23161 ttgcgttggc ttccagtatt ttaactggga aaccttttaa aggggattac gaaactttaa
    23221 caggtgattt taaattagca gaaggaaatc gagtgggaat gaaagcagaa ggttcattga
    23281 taaaaggtga atatgagatt tcgaaaggaa caaagcttac ttttaaaggg ggaaatggct
    23341 ccttagagac cagtgttcca atggatgaaa agacatttat tagtgatgtt gcaggagggg
    23401 ggttagtagg ctttaaagtt ggtgcttctc tttttgagga ctcaatagaa aaagaaataa
    23461 atagcggttt tgcagaaaaa gcaacagtta cacaaaagtt tgcagat
//
