Select genomic region:
Overview
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1.16

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP048002.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | T3PKS | 4,039,782 | 30,586 |
Region 2 | transAT-PKS | 145,293 | 251,469 | High | difficidin | PKS
Region 3 | terpene-precursor | 274,777 | 295,667 |
Region 4 | terpene-precursor,NRP-metallophore,NRPS,RiPP-like | 873,788 | 939,148 | High | bacillibactin | NRPS:Type I
Region 5 | lanthipeptide-class-ii | 1,107,676 | 1,134,038 |
Region 6 | other | 1,470,463 | 1,511,881 | High | bacilysin | other:other
Region 7 | NRPS,transAT-PKS | 2,024,390 | 2,102,101 | Low | locillomycin/locillomycin B/locillomycin C | NRPS:Type I+PKS
Region 8 | NRPS | 2,178,940 | 2,244,347 | High | surfactin | NRPS:Type I
Region 9 | phosphonate | 2,504,660 | 2,516,807 |
Region 10 | PKS-like | 2,807,516 | 2,848,760 |  |
Region 11 | terpene | 2,931,457 | 2,952,197 |
Region 12 | lanthipeptide-class-ii | 3,101,972 | 3,130,861 |
Region 13 | transAT-PKS | 3,299,345 | 3,387,575 | High | macrolactin H | PKS
Region 14 | transAT-PKS,T3PKS,NRPS | 3,611,616 | 3,721,730 | High | bacillaene | NRPS:Type I+PKS:Type I
Region 15 | NRPS,transAT-PKS,betalactone | 3,781,496 | 3,919,330 | High | fengycin | NRPS:Type I
Region 16 | terpene | 3,942,860 | 3,964,743 |

NZ_CP048002.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,039,782 - 30,586 nt. (total: 41,101 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase methyltransferase
GWK37_RS00080: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

GWK37_RS00090: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase
GWK37_RS00110: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Ligases: synthase
GWK37_RS00085: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002127.3 |  | 0.50 | PKS | flaviolin, 1,3,6,8-tetrahydroxynaphthalene | Streptomyces coelicolor A3(2)
BGC0000902.4 |  | 0.48 | PKS | flaviolin | Saccharopolyspora erythraea NRRL 2338
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0000285.5 |  | 0.42 | PKS, saccharide | flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin | Saccharopolyspora erythraea
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0002254.3 |  | 0.33 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0001964.2 |  | 0.33 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002127.3 |  | 0.50 | PKS | flaviolin, 1,3,6,8-tetrahydroxynaphthalene | Streptomyces coelicolor A3(2)
BGC0000902.4 |  | 0.48 | PKS | flaviolin | Saccharopolyspora erythraea NRRL 2338
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0000285.5 |  | 0.42 | PKS, saccharide | flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin | Saccharopolyspora erythraea
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0002254.3 |  | 0.33 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0001964.2 |  | 0.33 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97
Confidence: strong
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.70 out of 29.25
Confidence: medium
Additional weak hits (3):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.42 out of 28.14
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.07 out of 30.22
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.76 out of 26.06
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
SypG | Regulator of biofilm formation and host colonization

NZ_CP048002.1 - Region 2 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 145,293 - 251,469 nt. (total: 106,177 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
GWK37_RS00880: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

GWK37_RS00960: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS00985: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

GWK37_RS00990: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

GWK37_RS01000: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS01005: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS01020: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS01025: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS01070: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

GWK37_RS01095: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: acylase transferase
GWK37_RS01045: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

GWK37_RS01120: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: deacetylase hydrolase
GWK37_RS00965: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

GWK37_RS01115: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: hydratase
GWK37_RS00975: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
GWK37_RS00980: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

GWK37_RS00995: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

GWK37_RS01010: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

GWK37_RS01030: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.92 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001160.5 |  | 0.64 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.64 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0000181.5 |  | 0.61 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002056.3 |  | 0.58 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001795.3 |  | 0.54 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001201.3 |  | 0.52 | terpene | eremophilene | Sorangium cellulosum So ce56
BGC0001300.5 |  | 0.51 | PKS | anthracimycin | Streptomyces sp. CNH365

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.92 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001160.5 |  | 0.64 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.64 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0000181.5 |  | 0.61 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002056.3 |  | 0.58 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001795.3 |  | 0.54 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001201.3 |  | 0.52 | terpene | eremophilene | Sorangium cellulosum So ce56
BGC0001300.5 |  | 0.51 | PKS | anthracimycin | Streptomyces sp. CNH365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 23.28 out of 27.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.33 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78
Confidence: medium
Additional weak hits (10):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 145292 - 251469:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (Me-ccmal - ccmal - mal) + (ohmal - mal) + (mal) + (ccmal - ccmal - ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:
  GWK37_RS01020 + GWK37_RS01015 + GWK37_RS01010 + GWK37_RS01005 + GWK37_RS01000 + GWK37_RS00995 + GWK37_RS00990

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
GWK37_RS01030: X
AMP-binding (15..363): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
  Nearest Stachelhaus code(s):
    2,3-dohHda IGNPTGTIMK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

GWK37_RS01045: mal
PKS_AT (4..281): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 87.7
  inactive: 30.9
  Methoxymalonyl-CoA: 29.3
  Methylmalonyl-CoA: 21.7
  Propionyl-CoA: 16.5
  2-Methylbutyryl-CoA: 15.4
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
LexA variant 2 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis

NZ_CP048002.1 - Region 3 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 274,777 - 295,667 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
GWK37_RS01350: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
GWK37_RS01315: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

GWK37_RS01320: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
GWK37_RS01320: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
Additional weak hits (1):
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.69 out of 29.65
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
SypG | Regulator of biofilm formation and host colonization

NZ_CP048002.1 - Region 4 - NRP-metallophore,NRPS,RiPP-like,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 873,788 - 939,148 nt. (total: 65,361 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
GWK37_RS04560: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS04635: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS04685: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

GWK37_RS04690: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

GWK37_RS04740: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase
GWK37_RS04735: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: esterase hydrolase
GWK37_RS04480: thioesterase superfamily protein

smcogs
  SMCOG1144: thioesterase superfamily protein

GWK37_RS04525: isochorismatase

smcogs
  SMCOG1027: isochorismatase

GWK37_RS04620: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase
GWK37_RS04630: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthetase
GWK37_RS04500: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

GWK37_RS04615: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

GWK37_RS04625: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | NRP-metallophore | NRPS | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0000616.4 |  |  |  |  | 2.43 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  |  |  |  | 1.61 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  |  |  | 1.07 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  |  |  | 1.04 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  |  |  | 0.87 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  |  |  | 0.86 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.95 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  | 0.93 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.81 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
GWK37_RS04500: PT_FPPS_like
Domain 1 (43 - 297): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
Additional weak hits (21):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.19 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.34 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.55 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 873787 - 939148:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 887355 - 939092:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
GWK37_RS04615: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (456..855): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1513..1929): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS04625: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SLSLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (97% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP048002.1 - Region 5 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,107,676 - 1,134,038 nt. (total: 26,363 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
GWK37_RS05690: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

GWK37_RS05700: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000517.4 |  | 0.57 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.55 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001311.5 |  | 0.54 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001391.3 |  | 0.52 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000500.5 |  | 0.51 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000517.4 |  | 0.57 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.55 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001311.5 |  | 0.54 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001391.3 |  | 0.52 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000500.5 |  | 0.51 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for GWK37_RS05690

GWK37_RS05695
Leader:
MKKDMVKKASGFIEEDELISLANGDNATGG
Core:
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
Core with dehydrations:
A Dhb P Dhb V V L Dhb A Dhb I G L Dhb G Dhb Dhb F Dhb V Dhb L Dha A A Dha Cys P Dhb Dha A Cys Dhb K Q Cys N K

#### antiSMASH-DB 4.0 matches for GWK37_RS05695

100.0%
NZ_CP017953.1 and 15 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide
Lanthipeptides: BAMY_RS16390_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
97.4%
NZ_CP033054.1 and 11 others:
NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide
Lanthipeptides: D9777_RS18840_lanthipeptide
1
A T P-T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
1
A T P A T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
39
73.7%
NZ_JALAUA010000003.1 and 1 other:
NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide
Lanthipeptides: MOD32_RS04870_lanthipeptide
4
T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
T +L T A L T G T T F T V T L S A A S C P T S A C T C N K
5
T A I L T A---L T G T T F T V T L S A A S C P T S A C T N L C N K
36
with 104 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_CP047645.1 and 5 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide
Lanthipeptides: GSN02_RS17435_lanthipeptide
4
T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
T ++T A L T G T T F T V T L S A A S C P T S A C T C N K
5
T A I I T A---L T G T T F T V T L S A A S C P T S A C T N L C N K
36
63.2%
NZ_CKMQ01000043.1 and 8 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide
Lanthipeptides: AE832_RS09950_lanthipeptide
2
T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
T P T++ A T I G T F T V T L+A +C P T S C T K C N K
2
T P T I I-P A T I S F V G V T F T V T L N A G A C P T S G C T K S C N K
37
63.2%
NZ_PNGD01000001.1 and 1 other:
NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide
Lanthipeptides: CJ239_RS00165_lanthipeptide
2
T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
T P T++ A T I G T F T V T L+A +C P T S C T K C N K
2
T P T I I-A A T I S F A G V T F T V T L N A G A C P T S G C T K S C N K
37
47.4%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
36
A T P T+V+T A G +S A S C P T+A C T+ C
1
A T P T I V I T A I T G Y--------I S A N S C P T T A C T R A C
28
43.6%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide
Lanthipeptides: GCN81_RS29290_lanthipeptide
7
L T A T I G L T G T T F T V T L S A A---S C P T S A C T K Q C
36
+T T I L T V S A A C P T S C T K+C
8
I T P T I-L P A T G V I V G A S A A L Q G G C P T S G C T K R C
39
42.9%
NZ_BMSZ01000006.1 and 4 others:
NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide
Lanthipeptides: IE135_RS12790_lanthipeptide
2
T P T V V L T A T I G L T G T T F T V T L S A A---S C P T S A C T K Q C
36
T P T+V + T T V S A A C P T S C T K+C
9
T P T I V P A T A V----T T V I V G A S A A M Q G G C P T S G C T K R C
42
42.1%
NZ_CP102975.1 and 1 other:
NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide
Lanthipeptides: NW953_RS00175_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
A T P V V+T + V S A C P T A C+ +C K
1
A T P A V V I T G I L--------V A A S T A Q C P T L A C S S R C G K
30
42.1%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08310_lanthipeptide
Lanthipeptides: BJR39_RS08310_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
36
A T P T +L G G T +S +C P T+A C T+ C
1
A T P T A L L A---G A A G G V V T Y-V S N Q T C P T T A C T R A C
32
42.1%
NZ_JAENHN010000066.1 and 1 other:
NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide
Lanthipeptides: JHL18_RS24400_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N
37
T P V+ A T+G L T T A C T A C T C+
2
G T P C A V I-A T V G L T I K V A T----A V V C E T G A C T G Y C H
33
42.1%
NZ_QRWZ01000002.1 and 3 others:
NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: DWX18_RS02625_lanthipeptide
2
T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
36
T P T I G T +S A +C P T S A C T+ C
2
T P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
36

#### MIBiG 4.0 matches for GWK37_RS05695

26.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
20
V T L S A A S C P T S A C T K Q C
36
V +S A A C P T+ C T +C
21
V G V S A A F C P T T K C T S R C
37
15.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
27
C P T S A C T K Q C
36
C P T+ C T +C
17
C P T T K C T S K C
26
13.2%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
14
T G T T F T V T L S A A S C P T S
30
T G + A+C S
13
T G A L M G C N M K T A T C H C S
29
GWK37_RS05705
Leader:
MKKTKILKTPELKVTKDLNLIDPCGDVLEEIKEHEVSGA
Core:
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
Core with dehydrations:
F N Dhb W N Dhb Dhb Dhb Dhb Dha L G G I L V Dha E V L G N K G K V Cys Dhb G Dhb K E Cys Q G Dhb Cys

#### antiSMASH-DB 4.0 matches for GWK37_RS05705

100.0%
NZ_CP017953.1 and 27 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide
Lanthipeptides: BAMY_RS16400_lanthipeptide
1
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
1
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
91.9%
NZ_CP047645.1 and 7 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide
Lanthipeptides: GSN02_RS17445_lanthipeptide
1
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
F N T W N T T T T S+G I L V S E V G N K G K V C T G T K E C Q G T C
1
F N T W N T T T T S V G T I L V S E V F G N K G K V C T G T K E C Q G T C
37
60.5%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
1
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
N T W N T T T S I++S E G N K G K V C T T E C C
1
I N T W N T T A T S T S-I I I S E T F G N K G K V C T Y T V E C V N N C
36
with 110 more sequence matches
Only the first 10 are displayed here.
56.8%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
2
N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
N T W N T +T S I V S +G N G K V C T T E C C
1
N T W N T I S T S T C-I A V S H F V G N D G K V C T Y T V E C V N N C
35
54.1%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
5
N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
N T T T S I L+S L G N G V C T T K E C +C
4
N T L T T S-T S I L I S M T L G N N G W V C T A T K E C M P S C
35
51.3%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
4
W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
W T T T S L V S V G N G+V C T T E C Q C
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
48.6%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
5
N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
N T T T S I +S L G N G V C T +K E C +C
4
N T L T T S T S-I F I S R G L G N D G W V C T W S K E C M P S C
35
48.6%
NZ_GG657757.1 and 1 other:
NZ_GG657757.1 Lanthipeptides: SSQG_RS20730_lanthipeptide
Lanthipeptides: SSQG_RS20730_lanthipeptide
3
T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
+ N T T S L G I G N G C T T K E C Q +C
3
S A N F T T F S L S G I F-----G N D G D C C T L T K E C Q A S C
32
48.6%
NZ_KL997439.1 and 1 other:
NZ_KL997439.1 Lanthipeptides: IQ62_RS47105_lanthipeptide
Lanthipeptides: IQ62_RS47105_lanthipeptide
3
T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
+ N T T T +L S L G+K G C T T K E C Q +C
3
S L N T T T F T L-----S A Q L G D K G D C C T A T K E C Q P S C
32
47.4%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
4
W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
W T T +S L S V L G N G C T T E C Q C
4
W G T T L S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C
37
45.9%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
6
T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
T T T+L V S L G N G C T T E C Q C
5
T T V T T L S C Y G V S W A L G N D G N F C T A T V E C Q S N C
36
45.9%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide
Lanthipeptides: GHI93_RS00065_lanthipeptide
3
T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
T W N +S+ V+ L G N G V C T T E C Q C
3
T W N L V F S S V----V T L A L G N N G Y V C T W T H E C Q A N C
33
44.7%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
4
W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
W T +S L S V L G N G C T T E C Q C
4
W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37

#### MIBiG 4.0 matches for GWK37_RS05705

35.1%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
V S E V L G N K G K V C T G T K E C Q G T C
37
+S L G N G C T T K E C Q C
8
L S N A L G N N G G W C T L T K E C Q P N C
29
32.4%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
V S E V L G N K G K V C T G T K E C Q G T C
37
+S L G N K G C T T E C +C
6
I S C R L G N K G A Y C T L T V E C M P S C
27
17.9%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
27
C T G T K E C Q G T C
37
C T +K E C Q C
28
C T L S K E C Q P N C
38
allorf_1109061_1109207
Leader:
MLKLYTIYVFFHVIPLTMRMFLQSLPIA
Core:
L I S C R I I F F I N C K K Y D I L S A
Core with dehydrations:
L I Dha Cys R I I F F I N Cys K K Y D I L Dha A

#### antiSMASH-DB 4.0 matches for allorf_1109061_1109207

100.0%
NZ_CP048002.1:
Lanthipeptides: allorf_1109061_1109207_lanthipeptide
1
L I S C R I I F F I N C K K Y D I L S A
20
L I S C R I I F F I N C K K Y D I L S A
1
L I S C R I I F F I N C K K Y D I L S A
20
95.0%
NZ_CP017953.1 and 11 others:
NZ_CP021011.1 Lanthipeptides: allorf_1217915_1218061_lanthipeptide NZ_CP033054.1 Lanthipeptides: allorf_3701381_3701527_lanthipeptide NZ_CP041784.1 Lanthipeptides: allorf_3241959_3242105_lanthipeptide NZ_CP047268.1 Lanthipeptides: allorf_3722701_3722847_lanthipeptide NZ_CP072563.1 Lanthipeptides: allorf_3252899_3253045_lanthipeptide NZ_CP097784.1 Lanthipeptides: allorf_3200225_3200371_lanthipeptide NZ_CP116014.1 Lanthipeptides: allorf_3458073_3458219_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: allorf_294511_294657_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: allorf_145128_145274_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: allorf_252303_252449_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: allorf_294859_295005_lanthipeptide
Lanthipeptides: allorf_3266320_3266466_lanthipeptide
2
I S C R I I F F I N C K K Y D I L S A
20
I S C R I I F F I N C K K Y D I L S A
2
I S C R I I F F I N C K K Y D I L S A
20
23.1%
NC_023073.1 and 9 others:
NZ_CP016395.1 Lanthipeptides: BBJ33_RS20395_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21475_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19560_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19590_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20475_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06455_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06170_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06305_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19360_lanthipeptide
Lanthipeptides: U722_RS20000_lanthipeptide
9
F I N C K K Y D I L S A
20
F+ C+ D I L A
13
F L R C Q N D D I L P A
24
allorf_1109093_1109176
Leader:
MMKKMMRQDMRAIGS
Core:
D C K N I R I V S G I T
Core with dehydrations:
D Cys K N I R I V Dha G I Dhb

#### antiSMASH-DB 4.0 matches for allorf_1109093_1109176

100.0%
NZ_CP017953.1 and 12 others:
NZ_CP021011.1 Lanthipeptides: allorf_1217947_1218030_lanthipeptide NZ_CP033054.1 Lanthipeptides: allorf_3701413_3701496_lanthipeptide NZ_CP041784.1 Lanthipeptides: allorf_3241991_3242074_lanthipeptide NZ_CP047268.1 Lanthipeptides: allorf_3722733_3722816_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_1109093_1109176_lanthipeptide NZ_CP072563.1 Lanthipeptides: allorf_3252931_3253014_lanthipeptide NZ_CP097784.1 Lanthipeptides: allorf_3200257_3200340_lanthipeptide NZ_CP116014.1 Lanthipeptides: allorf_3458105_3458188_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: allorf_294543_294626_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: allorf_145159_145242_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: allorf_252335_252418_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: allorf_294891_294974_lanthipeptide
Lanthipeptides: allorf_3266352_3266435_lanthipeptide
1
D C K N I R I V S G I T
12
D C K N I R I V S G I T
1
D C K N I R I V S G I T
12
allorf_1130609_1130839
Leader:
MVLSDRNAIMKADKGRGRTPFPFFHENRLSESAGL
Core:
L Q N V R V L K F P R H F R F L S R L P W L R R R S A P C P E A A I C P A A E A S
Core with dehydrations:
L Q N V R V L K F P R H F R F L Dha R L P W L R R R Dha A P Cys P E A A I Cys P A A E A Dha

#### antiSMASH-DB 4.0 matches for allorf_1130609_1130839

100.0%
NZ_CP017953.1 and 12 others:
NZ_CP021011.1 Lanthipeptides: allorf_1239450_1239680_lanthipeptide NZ_CP033054.1 Lanthipeptides: allorf_3724234_3724464_lanthipeptide NZ_CP041784.1 Lanthipeptides: allorf_3263499_3263729_lanthipeptide NZ_CP047268.1 Lanthipeptides: allorf_3744242_3744472_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_1130609_1130839_lanthipeptide NZ_CP072563.1 Lanthipeptides: allorf_3274357_3274587_lanthipeptide NZ_CP097784.1 Lanthipeptides: allorf_3221763_3221993_lanthipeptide NZ_CP116014.1 Lanthipeptides: allorf_3479615_3479845_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: allorf_316050_316280_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: allorf_123482_123712_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: allorf_273844_274074_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: allorf_316397_316627_lanthipeptide
Lanthipeptides: allorf_3287857_3288087_lanthipeptide
1
L Q N V R V L K F P R H F R F L S R L P W L R R R S A P C P E A A I C P A A E A S
41
L Q N V R V L K F P R H F R F L S R L P W L R R R S A P C P E A A I C P A A E A S
1
L Q N V R V L K F P R H F R F L S R L P W L R R R S A P C P E A A I C P A A E A S
41
31.7%
NZ_CP011020.1:
Lanthipeptides: allorf_1818981_1819088_lanthipeptide
16
L S R L P W L R R R S A P C-----P E A A I C P A
37
L+R L + R R S P A A I C P A
1
L A R L C F G L R R S L P V R H G Q R Q N A A I C P A
27
19.5%
NZ_FOYL01000002.1:
Lanthipeptides: allorf_0629623_0629850_lanthipeptide
17
S R L P W L R R R S A P C
29
S R W+R R S P C
14
S R A T W V R M R S G P C
26
with 2 more sequence matches
14.3%
NZ_BNCA01000011.1:
Lanthipeptides: allorf_160997_161218_lanthipeptide
20
P W L R R R S A P C P E A A I C P
36
P R+ P C P A C P
37
P P D R Q P P G P C P P A G S C P
53
13.5%
NZ_JAHTIK010000001.1:
Lanthipeptides: allorf_2154999_2155214_lanthipeptide
19
L P W L R R R S A P C P
30
L P W R P C P
2
L P W R M R D G G P C P
13

#### Lanthipeptide(s) for GWK37_RS05700

GWK37_RS05695
Leader:
MKKDMVKKASGFIEEDELISLANGDNATGG
Core:
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
Core with dehydrations:
A Dhb P Dhb V V L Dhb A Dhb I G L Dhb G Dhb Dhb F Dhb V Dhb L Dha A A Dha Cys P Dhb Dha A Cys Dhb K Q Cys N K

#### antiSMASH-DB 4.0 matches for GWK37_RS05695

100.0%
NZ_CP017953.1 and 15 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide
Lanthipeptides: BAMY_RS16390_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
97.4%
NZ_CP033054.1 and 11 others:
NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide
Lanthipeptides: D9777_RS18840_lanthipeptide
1
A T P-T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
1
A T P A T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
39
73.7%
NZ_JALAUA010000003.1 and 1 other:
NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide
Lanthipeptides: MOD32_RS04870_lanthipeptide
4
T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
T +L T A L T G T T F T V T L S A A S C P T S A C T C N K
5
T A I L T A---L T G T T F T V T L S A A S C P T S A C T N L C N K
36
with 104 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_CP047645.1 and 5 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide
Lanthipeptides: GSN02_RS17435_lanthipeptide
4
T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
T ++T A L T G T T F T V T L S A A S C P T S A C T C N K
5
T A I I T A---L T G T T F T V T L S A A S C P T S A C T N L C N K
36
63.2%
NZ_CKMQ01000043.1 and 8 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide
Lanthipeptides: AE832_RS09950_lanthipeptide
2
T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
T P T++ A T I G T F T V T L+A +C P T S C T K C N K
2
T P T I I-P A T I S F V G V T F T V T L N A G A C P T S G C T K S C N K
37
63.2%
NZ_PNGD01000001.1 and 1 other:
NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide
Lanthipeptides: CJ239_RS00165_lanthipeptide
2
T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
T P T++ A T I G T F T V T L+A +C P T S C T K C N K
2
T P T I I-A A T I S F A G V T F T V T L N A G A C P T S G C T K S C N K
37
47.4%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
36
A T P T+V+T A G +S A S C P T+A C T+ C
1
A T P T I V I T A I T G Y--------I S A N S C P T T A C T R A C
28
43.6%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide
Lanthipeptides: GCN81_RS29290_lanthipeptide
7
L T A T I G L T G T T F T V T L S A A---S C P T S A C T K Q C
36
+T T I L T V S A A C P T S C T K+C
8
I T P T I-L P A T G V I V G A S A A L Q G G C P T S G C T K R C
39
42.9%
NZ_BMSZ01000006.1 and 4 others:
NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide
Lanthipeptides: IE135_RS12790_lanthipeptide
2
T P T V V L T A T I G L T G T T F T V T L S A A---S C P T S A C T K Q C
36
T P T+V + T T V S A A C P T S C T K+C
9
T P T I V P A T A V----T T V I V G A S A A M Q G G C P T S G C T K R C
42
42.1%
NZ_CP102975.1 and 1 other:
NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide
Lanthipeptides: NW953_RS00175_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N K
38
A T P V V+T + V S A C P T A C+ +C K
1
A T P A V V I T G I L--------V A A S T A Q C P T L A C S S R C G K
30
42.1%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08310_lanthipeptide
Lanthipeptides: BJR39_RS08310_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
36
A T P T +L G G T +S +C P T+A C T+ C
1
A T P T A L L A---G A A G G V V T Y-V S N Q T C P T T A C T R A C
32
42.1%
NZ_JAENHN010000066.1 and 1 other:
NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide
Lanthipeptides: JHL18_RS24400_lanthipeptide
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C N
37
T P V+ A T+G L T T A C T A C T C+
2
G T P C A V I-A T V G L T I K V A T----A V V C E T G A C T G Y C H
33
42.1%
NZ_QRWZ01000002.1 and 3 others:
NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: DWX18_RS02625_lanthipeptide
2
T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
36
T P T I G T +S A +C P T S A C T+ C
2
T P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
36

#### MIBiG 4.0 matches for GWK37_RS05695

26.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
20
V T L S A A S C P T S A C T K Q C
36
V +S A A C P T+ C T +C
21
V G V S A A F C P T T K C T S R C
37
15.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
27
C P T S A C T K Q C
36
C P T+ C T +C
17
C P T T K C T S K C
26
13.2%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
14
T G T T F T V T L S A A S C P T S
30
T G + A+C S
13
T G A L M G C N M K T A T C H C S
29
GWK37_RS05705
Leader:
MKKTKILKTPELKVTKDLNLIDPCGDVLEEIKEHEVSGA
Core:
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
Core with dehydrations:
F N Dhb W N Dhb Dhb Dhb Dhb Dha L G G I L V Dha E V L G N K G K V Cys Dhb G Dhb K E Cys Q G Dhb Cys

#### antiSMASH-DB 4.0 matches for GWK37_RS05705

100.0%
NZ_CP017953.1 and 27 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide
Lanthipeptides: BAMY_RS16400_lanthipeptide
1
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
1
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
91.9%
NZ_CP047645.1 and 7 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide
Lanthipeptides: GSN02_RS17445_lanthipeptide
1
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
F N T W N T T T T S+G I L V S E V G N K G K V C T G T K E C Q G T C
1
F N T W N T T T T S V G T I L V S E V F G N K G K V C T G T K E C Q G T C
37
60.5%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
1
F N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
N T W N T T T S I++S E G N K G K V C T T E C C
1
I N T W N T T A T S T S-I I I S E T F G N K G K V C T Y T V E C V N N C
36
with 110 more sequence matches
Only the first 10 are displayed here.
56.8%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
2
N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
N T W N T +T S I V S +G N G K V C T T E C C
1
N T W N T I S T S T C-I A V S H F V G N D G K V C T Y T V E C V N N C
35
54.1%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
5
N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
N T T T S I L+S L G N G V C T T K E C +C
4
N T L T T S-T S I L I S M T L G N N G W V C T A T K E C M P S C
35
51.3%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
4
W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
W T T T S L V S V G N G+V C T T E C Q C
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
48.6%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
5
N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
N T T T S I +S L G N G V C T +K E C +C
4
N T L T T S T S-I F I S R G L G N D G W V C T W S K E C M P S C
35
48.6%
NZ_GG657757.1 and 1 other:
NZ_GG657757.1 Lanthipeptides: SSQG_RS20730_lanthipeptide
Lanthipeptides: SSQG_RS20730_lanthipeptide
3
T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
+ N T T S L G I G N G C T T K E C Q +C
3
S A N F T T F S L S G I F-----G N D G D C C T L T K E C Q A S C
32
48.6%
NZ_KL997439.1 and 1 other:
NZ_KL997439.1 Lanthipeptides: IQ62_RS47105_lanthipeptide
Lanthipeptides: IQ62_RS47105_lanthipeptide
3
T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
+ N T T T +L S L G+K G C T T K E C Q +C
3
S L N T T T F T L-----S A Q L G D K G D C C T A T K E C Q P S C
32
47.4%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
4
W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
W T T +S L S V L G N G C T T E C Q C
4
W G T T L S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C
37
45.9%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
6
T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
T T T+L V S L G N G C T T E C Q C
5
T T V T T L S C Y G V S W A L G N D G N F C T A T V E C Q S N C
36
45.9%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide
Lanthipeptides: GHI93_RS00065_lanthipeptide
3
T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
T W N +S+ V+ L G N G V C T T E C Q C
3
T W N L V F S S V----V T L A L G N N G Y V C T W T H E C Q A N C
33
44.7%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
4
W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
W T +S L S V L G N G C T T E C Q C
4
W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37

#### MIBiG 4.0 matches for GWK37_RS05705

35.1%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
V S E V L G N K G K V C T G T K E C Q G T C
37
+S L G N G C T T K E C Q C
8
L S N A L G N N G G W C T L T K E C Q P N C
29
32.4%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
V S E V L G N K G K V C T G T K E C Q G T C
37
+S L G N K G C T T E C +C
6
I S C R L G N K G A Y C T L T V E C M P S C
27
17.9%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
27
C T G T K E C Q G T C
37
C T +K E C Q C
28
C T L S K E C Q P N C
38
allorf_1130609_1130839
Leader:
MVLSDRNAIMKADKGRGRTPFPFFHENRLSESAGL
Core:
L Q N V R V L K F P R H F R F L S R L P W L R R R S A P C P E A A I C P A A E A S
Core with dehydrations:
L Q N V R V L K F P R H F R F L Dha R L P W L R R R Dha A P Cys P E A A I Cys P A A E A Dha

#### antiSMASH-DB 4.0 matches for allorf_1130609_1130839

100.0%
NZ_CP017953.1 and 12 others:
NZ_CP021011.1 Lanthipeptides: allorf_1239450_1239680_lanthipeptide NZ_CP033054.1 Lanthipeptides: allorf_3724234_3724464_lanthipeptide NZ_CP041784.1 Lanthipeptides: allorf_3263499_3263729_lanthipeptide NZ_CP047268.1 Lanthipeptides: allorf_3744242_3744472_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_1130609_1130839_lanthipeptide NZ_CP072563.1 Lanthipeptides: allorf_3274357_3274587_lanthipeptide NZ_CP097784.1 Lanthipeptides: allorf_3221763_3221993_lanthipeptide NZ_CP116014.1 Lanthipeptides: allorf_3479615_3479845_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: allorf_316050_316280_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: allorf_123482_123712_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: allorf_273844_274074_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: allorf_316397_316627_lanthipeptide
Lanthipeptides: allorf_3287857_3288087_lanthipeptide
1
L Q N V R V L K F P R H F R F L S R L P W L R R R S A P C P E A A I C P A A E A S
41
L Q N V R V L K F P R H F R F L S R L P W L R R R S A P C P E A A I C P A A E A S
1
L Q N V R V L K F P R H F R F L S R L P W L R R R S A P C P E A A I C P A A E A S
41
31.7%
NZ_CP011020.1:
Lanthipeptides: allorf_1818981_1819088_lanthipeptide
16
L S R L P W L R R R S A P C-----P E A A I C P A
37
L+R L + R R S P A A I C P A
1
L A R L C F G L R R S L P V R H G Q R Q N A A I C P A
27
19.5%
NZ_FOYL01000002.1:
Lanthipeptides: allorf_0629623_0629850_lanthipeptide
17
S R L P W L R R R S A P C
29
S R W+R R S P C
14
S R A T W V R M R S G P C
26
with 2 more sequence matches
14.3%
NZ_BNCA01000011.1:
Lanthipeptides: allorf_160997_161218_lanthipeptide
20
P W L R R R S A P C P E A A I C P
36
P R+ P C P A C P
37
P P D R Q P P G P C P P A G S C P
53
13.5%
NZ_JAHTIK010000001.1:
Lanthipeptides: allorf_2154999_2155214_lanthipeptide
19
L P W L R R R S A P C P
30
L P W R P C P
2
L P W R M R D G G P C P
13

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 29.41 out of 36.54
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.20 out of 26.06
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.98 out of 18.16
Confidence: strong
Additional weak hits (8):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.22 out of 28.14
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.83 out of 26.12
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.01 out of 28.14
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.87 out of 27.55
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.14 out of 30.22
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.73 out of 29.65
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.66 out of 32.93
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 19.59 out of 30.12
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

GWK37_RS05695 - Class II
  Cleavage pHMM score: -5.10
  RODEO score: 0
  Monoisotopic mass: 3505.9 Da
  Molecular weight: 3508.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3526.1 Da N = 1
    3544.1 Da N = 2
    3562.1 Da N = 3
    3580.1 Da N = 4
    3598.1 Da N = 5
    3616.2 Da N = 6
    3634.2 Da N = 7
    3652.2 Da N = 8
    3670.2 Da N = 9
    3688.2 Da N = 10
    3706.3 Da N = 11
GWK37_RS05705 - Class II
  Cleavage pHMM score: -3.20
  RODEO score: 0
  Monoisotopic mass: 3666.9 Da
  Molecular weight: 3669.1 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3687.1 Da N = 1
    3705.2 Da N = 2
    3723.2 Da N = 3
    3741.2 Da N = 4
    3759.2 Da N = 5
    3777.2 Da N = 6
    3795.3 Da N = 7
allorf_1130609_1130839 - Class II
  Cleavage pHMM score: -5.70
  RODEO score: 0
  Monoisotopic mass: 4704.6 Da
  Molecular weight: 4707.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4725.5 Da N = 1
GWK37_RS05695 - Class II
  Cleavage pHMM score: -5.10
  RODEO score: 0
  Monoisotopic mass: 3505.9 Da
  Molecular weight: 3508.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3526.1 Da N = 1
    3544.1 Da N = 2
    3562.1 Da N = 3
    3580.1 Da N = 4
    3598.1 Da N = 5
    3616.2 Da N = 6
    3634.2 Da N = 7
    3652.2 Da N = 8
    3670.2 Da N = 9
    3688.2 Da N = 10
    3706.3 Da N = 11
GWK37_RS05705 - Class II
  Cleavage pHMM score: -3.20
  RODEO score: 0
  Monoisotopic mass: 3666.9 Da
  Molecular weight: 3669.1 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3687.1 Da N = 1
    3705.2 Da N = 2
    3723.2 Da N = 3
    3741.2 Da N = 4
    3759.2 Da N = 5
    3777.2 Da N = 6
    3795.3 Da N = 7
allorf_1109061_1109207 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 2323.3 Da
  Molecular weight: 2324.8 Da
  Number of bridges: 2
allorf_1109093_1109176 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 1281.7 Da
  Molecular weight: 1282.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1300.5 Da N = 1
allorf_1130609_1130839 - Class II
  Cleavage pHMM score: -5.70
  RODEO score: 0
  Monoisotopic mass: 4704.6 Da
  Molecular weight: 4707.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4725.5 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
HgtR | Hydrogen-dependent regulator
MogR | Repressor of flagellar motility genes

NZ_CP048002.1 - Region 6 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,470,463 - 1,511,881 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
GWK37_RS07515: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS07535: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS07570: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase
GWK37_RS07520: aminotransferase

smcogs
  SMCOG1019: aminotransferase

GWK37_RS07620: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Lyases: dehydratase lyase
GWK37_RS07530: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

GWK37_RS07610: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

GWK37_RS07615: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease
GWK37_RS07425: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

GWK37_RS07560: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.4 |  | 0.97 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000888.5 |  | 0.96 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000773.3 |  | 0.54 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000898.5 |  | 0.53 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000790.3 |  | 0.53 | saccharide | O-antigen | Escherichia coli
BGC0000791.3 |  | 0.52 | saccharide | O-antigen | Cronobacter sakazakii
BGC0001928.2 |  | 0.51 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000813.3 |  | 0.51 | other (other) | K-252a | Nonomuraea longicatena
BGC0000768.5 |  | 0.51 | saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.4 |  | 0.97 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000888.5 |  | 0.96 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000773.3 |  | 0.54 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000898.5 |  | 0.53 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000790.3 |  | 0.53 | saccharide | O-antigen | Escherichia coli
BGC0000791.3 |  | 0.52 | saccharide | O-antigen | Cronobacter sakazakii
BGC0001928.2 |  | 0.51 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000813.3 |  | 0.51 | other (other) | K-252a | Nonomuraea longicatena
BGC0000768.5 |  | 0.51 | saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.03 out of 26.85
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.26 out of 29.38
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33
Confidence: medium
Additional weak hits (9):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.45 out of 30.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.99 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.26 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.43 out of 26.06
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
RutR | Regulator of the pyrimidine and purine metabolism
ToxT | Regulator of MSHA biosynthesis

NZ_CP048002.1 - Region 7 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,024,390 - 2,102,101 nt. (total: 77,712 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
GWK37_RS10320: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

GWK37_RS10410: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

GWK37_RS10505: dehydrogenase

smcogs
  SMCOG1181: dehydrogenase

Transferases: acylase acyltransferase methyltransferase
GWK37_RS10395: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

GWK37_RS10420: O-methyltransferase

smcogs
  SMCOG1042: O-methyltransferase

GWK37_RS19940: polyketide synthase associated protein papA3

smcogs
  SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: esterase
GWK37_RS10380: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
GWK37_RS10400: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

GWK37_RS10405: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

GWK37_RS10415: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

GWK37_RS19935: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease
GWK37_RS10340: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

GWK37_RS10445: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  | 0.87 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  | 0.82 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.82 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  | 0.82 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001261.3 |  |  | 0.81 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  |  | 0.81 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001249.5 |  |  | 0.81 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001132.4 |  |  | 0.80 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  |  | 0.75 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.72 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001261.3 |  | 0.72 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.72 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001825.4 |  | 0.69 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.01 out of 30.22
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.77 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.63 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.15 out of 26.06
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.19 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.42 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.97 out of 21.55
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33
Confidence: medium
Additional weak hits (8):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.55 out of 30.22
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 25.54 out of 35.63
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.71 out of 20.47
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.30 out of 32.93
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 2024389 - 2102101:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val - D-Phe - Asp) + (D-Asn - Gly) + (ccmal) + (ccmal) + (mal - D-Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
GWK37_RS19935: Val - Phe
Search NORINE for peptide: strict or relaxed
AMP-binding (248..645): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LETAFDASTFEGWLLVGGDINGYGPTEGTTFTCC
  Nearest Stachelhaus code(s):
    Val DAFWLGGTFK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1285..1675): Phe
nrpys: Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LVFAFDASVWEMTLITAGSINAYGPTETTICSTM
  Nearest Stachelhaus code(s):
    Phe DAWTIAAICK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS19940: Asp - Asn - Gly
Search NORINE for peptide: strict or relaxed
AMP-binding (264..665): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWVSFDLCYTSPKMILGGEINHYGPTESTIGCIA
  Nearest Stachelhaus code(s):
    Asp DLTKIGHIGK (82% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1303..1697): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEYNEYGPTEATVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2805..3198): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGITFDIFGLELQLMVGGEYNMYGPTETTIWSSV
  Nearest Stachelhaus code(s):
    Gly DILQMGMVWK (85% 8Å match)
  Stachelhaus code match:
    90% (moderate)

GWK37_RS10395: mal
PKS_AT (6..293): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 75.0%
  2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 111.1
  inactive: 50.8
  Methoxymalonyl-CoA: 39.3
  Isobutyryl-CoA: 31.6
  Methylmalonyl-CoA: 29.7
  Propionyl-CoA: 12.0
  CHC-CoA: 10.8
  fatty_acid: 10.4
  Benzoyl-CoA: 10.0
  trans-1,2-CPDA: 0.0
  Ethylmalonyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

GWK37_RS10415: Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (1197..1598): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LALAFDASVKQSDGIIGGETNVYGPTECCVDAAA
  Nearest Stachelhaus code(s):
    Glu DAKDIGVVDK (82% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
ArcA | Repressor of carbon oxidation
ClgR | Caseinolytic protease gene regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP048002.1 - Region 8 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,178,940 - 2,244,347 nt. (total: 65,408 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase
GWK37_RS10880: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

GWK37_RS10895: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

GWK37_RS10900: flavodoxin

smcogs
  SMCOG1134: flavodoxin

GWK37_RS10905: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

GWK37_RS10920: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

GWK37_RS11070: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase
GWK37_RS10985: aminotransferase

smcogs
  SMCOG1019: aminotransferase

GWK37_RS10990: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase
GWK37_RS10980: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
GWK37_RS10915: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

GWK37_RS10965: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

GWK37_RS10975: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

GWK37_RS19760: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

GWK37_RS19770: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.5 |  | 0.85 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.5 |  | 0.85 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
Additional weak hits (17):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.23 out of 36.54
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.78 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.72 out of 26.06
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.63 out of 36.54
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.92 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 23.04 out of 30.12
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 11, location 2178939 - 2244347:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - D-Leu) + (Val) + (Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
GWK37_RS10965: Glu - Leu - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (465..867): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1511..1908): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
  Nearest Stachelhaus code(s):
    Leu DAFMMGMVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2550..2939): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS19760: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (452..846): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS19770: Asp - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (429..831): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1474..1863): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS10975: Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (469..867): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
  Nearest Stachelhaus code(s):
    Leu DAFFLGCVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP048002.1 - Region 9 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,504,660 - 2,516,807 nt. (total: 12,148 nt) Show pHMM detection rules used
phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
GWK37_RS12515: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Lyases: lyase
GWK37_RS12500: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase
GWK37_RS12495: carbamoyl phosphate synthase small subunit

smcogs
  SMCOG1249: carbamoyl phosphate synthase small subunit

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000897.5 |  | 0.47 | other (other) | dehydrophos | Streptomyces luridus
BGC0002313.3 |  | 0.46 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000926.5 |  | 0.46 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000904.5 |  | 0.45 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0001859.4 |  | 0.45 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0002036.4 |  | 0.39 | other (other) | dehydrofosmidomycin | Streptomyces lavendulae
BGC0001739.3 |  | 0.39 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000937.5 |  | 0.39 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0001151.5 |  | 0.37 | other (non-nrp beta-lactam) | valclavam, (-)-2-(2-hydroxyethyl)clavam | Streptomyces antibioticus
BGC0002294.3 |  | 0.37 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000897.5 |  | 0.47 | other (other) | dehydrophos | Streptomyces luridus
BGC0002313.3 |  | 0.46 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000926.5 |  | 0.46 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000904.5 |  | 0.45 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0001859.4 |  | 0.45 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0002036.4 |  | 0.39 | other (other) | dehydrofosmidomycin | Streptomyces lavendulae
BGC0001739.3 |  | 0.39 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000937.5 |  | 0.39 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0001151.5 |  | 0.37 | other (non-nrp beta-lactam) | valclavam, (-)-2-(2-hydroxyethyl)clavam | Streptomyces antibioticus
BGC0002294.3 |  | 0.37 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.26 out of 28.19
Confidence: medium
Additional weak hits (4):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.89 out of 23.43
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.40 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.56 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.28 out of 30.25
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1 | Zinc-responsive repressor

NZ_CP048002.1 - Region 10 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,807,516 - 2,848,760 nt. (total: 41,245 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
GWK37_RS14000: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase
GWK37_RS14030: acyltransferase

smcogs
  SMCOG1141: acyltransferase

GWK37_RS14045: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase
GWK37_RS14090: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: synthase
GWK37_RS14050: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease
GWK37_RS14005: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.50 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.43 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001206.5 |  | 0.42 | other (other) | indolmycin | Streptomyces griseus subsp. griseus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.50 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.43 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001206.5 |  | 0.42 | other (other) | indolmycin | Streptomyces griseus subsp. griseus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.49 out of 25.88
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
Additional weak hits (12):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.22 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP048002.1 - Region 11 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,931,457 - 2,952,197 nt. (total: 20,741 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
GWK37_RS14660: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: aminotransferase
GWK37_RS14675: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase
GWK37_RS14635: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002458.3 |  | 0.49 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000885.3 |  | 0.47 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001488.3 |  | 0.38 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.35 | PKS | trehangelin | Polymorphospora rubra
BGC0000720.3 |  | 0.35 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001735.5 |  | 0.35 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002458.3 |  | 0.49 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000885.3 |  | 0.47 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001488.3 |  | 0.38 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.35 | PKS | trehangelin | Polymorphospora rubra
BGC0000720.3 |  | 0.35 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001735.5 |  | 0.35 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | squalene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
GWK37_RS14640: PT_phytoene_like
Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → squalene
  FPP → PSPP
  FPP → diapophytoene
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.23 out of 20.97
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33
Confidence: medium
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19
Confidence: medium
Additional weak hits (4):
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR | NAD synthesis repressor
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_CP048002.1 - Region 12 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,101,972 - 3,130,861 nt. (total: 28,890 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
GWK37_RS15590: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

GWK37_RS15600: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.52 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001311.5 |  | 0.50 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000527.5 |  | 0.49 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.52 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001311.5 |  | 0.50 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000527.5 |  | 0.49 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for GWK37_RS15590

GWK37_RS15585
Leader:
MNEKMYRFAGDLREELEEISLS
Core:
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
Core with dehydrations:
E F Dha G G G G A E Q R G I Dha Q G N D G K L Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for GWK37_RS15585

100.0%
NC_023073.1 and 65 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
97.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C+C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
86.8%
NZ_CP016371.1 and 7 others:
NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide
Lanthipeptides: A5891_RS06120_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
33
with 92 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C-W C
38
A E Q R G I S Q G N D G K C T L T W E C +C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
68.4%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
68.4%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E R G I S Q G N D G C T+T W E C G+C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.4%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
65.8%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
65.8%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E R G+S Q G N D G C T+T W E C G+C P T H T C W C
1
A D V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
63.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S+ N D G K C T L T W E C +C P T H T C W C
1
A A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
63.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A+ +G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
55.3%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
5
G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W
37
G G R +S+G N G K+C T L T W E C G+C P+H T C+
1
G V G K W I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for GWK37_RS15585

23.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G N D G K L C T L T W E C
28
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
23.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G N D G K L C T L T W E C
28
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
15.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
6
G G A E Q R G I S Q
15
G G G I S Q
10
G G I T T L G I S Q
19
with 1 more sequence matches
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
22
C T L T W E C
28
C T L+ E C
28
C T L S K E C
34
GWK37_RS19655
Leader:
MKKEFLALELMTEEELKELAGG
Core:
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha E A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for GWK37_RS19655

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide
Lanthipeptides: J7E20_RS10240_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N
35
+E+T P T P T I I P+S L A C P T T+C A S I V C N
1
A E S T P-N G T P A T I-I P V S L A I C P T T R C A S I V E S C N
33
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
61.1%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
+A T P T P T T I I P+S L A C P T T C S S P C
2
D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
60.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
60.5%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29

#### MIBiG 4.0 matches for GWK37_RS19655

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
GWK37_RS19660
Leader:
MKKDFQALTPMTEEELKNLAGG
Core:
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha D A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for GWK37_RS19660

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
94.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
D A T P T P T T I I P+S L A C P T T C S S P C
1
E D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
63.2%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29
55.6%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S C N
6
T I I I P I S L A A C P T T R C A S I V S S C N
29
55.6%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T+C A S I V C N
8
T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34

#### MIBiG 4.0 matches for GWK37_RS19660

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
allorf_3117293_3117475
Leader:
MKGGEIWNMKKNFSALYETSEQELKELVGG
Core:
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
Core with dehydrations:
Q N Dha V Dha I Dhb Dhb Y P I Dhb N H I Cys P Dhb I Dhb V G Cys A Cys P Q R Q V

#### antiSMASH-DB 4.0 matches for allorf_3117293_3117475

100.0%
NZ_CP016371.1 and 25 others:
NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide
Lanthipeptides: allorf_1203980_1204162_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
93.3%
NC_023073.1 and 18 others:
NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide
Lanthipeptides: allorf_1238739_1238921_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T P I T N H+C P T I T V G C A C P Q R Q V
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
66.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N +S I T T P T H+C T+T V G C A C P Q+Q+
1
Q N L I S I T T I P F T-H L C A T V T V G C A C P Q K Q I
29
with 3 more sequence matches
23.5%
NZ_CP048048.1 and 2 others:
NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptide NZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide
Lanthipeptides: GW571_RS15175_lanthipeptide
8
T Y P I T N H I C P T I T V G C A C P Q R Q
29
T+ +T +C T I A C Q
8
T F K L T V K V C R T I I T T T A C G S T Q
29
20.0%
NZ_JANIOB010000033.1:
Lanthipeptides: NQ113_RS28010_lanthipeptide
11
I T N H I C P T I
19
T N +C P T I
15
F T N R L C P T I
23
15.8%
NZ_KB907258.1:
Lanthipeptides: G358_RS0114910_lanthipeptide
2
N S V S I T T Y P I T N H I C P T I T
20
N S+ I+ Y + C P++
6
N S I R I S I Y K C L S L F C P S V A
24

#### MIBiG 4.0 matches for allorf_3117293_3117475

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
18
T I T V G C
23
T+T V C
18
T L T V E C
23
allorf_3123788_3123865
Leader:
MRIHSIFIRMQGLYA
Core:
Q V I C P T N A T Y
Core with dehydrations:
Q V I Cys P Dhb N A Dhb Y

#### antiSMASH-DB 4.0 matches for allorf_3123788_3123865

100.0%
NZ_CP016371.1 and 22 others:
NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide
Lanthipeptides: allorf_1210473_1210550_lanthipeptide
1
Q V I C P T N A T Y
10
Q V I C P T N A T Y
1
Q V I C P T N A T Y
10

#### Lanthipeptide(s) for GWK37_RS15600

GWK37_RS15585
Leader:
MNEKMYRFAGDLREELEEISLS
Core:
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
Core with dehydrations:
E F Dha G G G G A E Q R G I Dha Q G N D G K L Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for GWK37_RS15585

100.0%
NC_023073.1 and 65 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
97.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C+C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
86.8%
NZ_CP016371.1 and 7 others:
NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide
Lanthipeptides: A5891_RS06120_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
33
with 92 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C-W C
38
A E Q R G I S Q G N D G K C T L T W E C +C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
68.4%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
68.4%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E R G I S Q G N D G C T+T W E C G+C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.4%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
65.8%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
65.8%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E R G+S Q G N D G C T+T W E C G+C P T H T C W C
1
A D V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
63.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S+ N D G K C T L T W E C +C P T H T C W C
1
A A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
63.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A+ +G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
55.3%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
5
G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W
37
G G R +S+G N G K+C T L T W E C G+C P+H T C+
1
G V G K W I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for GWK37_RS15585

23.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G N D G K L C T L T W E C
28
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
23.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G N D G K L C T L T W E C
28
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
15.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
6
G G A E Q R G I S Q
15
G G G I S Q
10
G G I T T L G I S Q
19
with 1 more sequence matches
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
22
C T L T W E C
28
C T L+ E C
28
C T L S K E C
34
GWK37_RS19655
Leader:
MKKEFLALELMTEEELKELAGG
Core:
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha E A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for GWK37_RS19655

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide
Lanthipeptides: J7E20_RS10240_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N
35
+E+T P T P T I I P+S L A C P T T+C A S I V C N
1
A E S T P-N G T P A T I-I P V S L A I C P T T R C A S I V E S C N
33
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
61.1%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
+A T P T P T T I I P+S L A C P T T C S S P C
2
D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
60.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
60.5%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29

#### MIBiG 4.0 matches for GWK37_RS19655

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
GWK37_RS19660
Leader:
MKKDFQALTPMTEEELKNLAGG
Core:
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha D A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for GWK37_RS19660

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
94.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
D A T P T P T T I I P+S L A C P T T C S S P C
1
E D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
63.2%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29
55.6%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S C N
6
T I I I P I S L A A C P T T R C A S I V S S C N
29
55.6%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T+C A S I V C N
8
T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34

#### MIBiG 4.0 matches for GWK37_RS19660

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
GWK37_RS19665
Leader:
MCKLCGPKKVIVTETGFGA
Core:
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V Q I Y
Core with dehydrations:
V F H P Cys P N Cys K Dhb G Dhb D L Dhb P V I K R L E R M V Q D A K V R L D A R V Q I Y

#### antiSMASH-DB 4.0 matches for GWK37_RS19665

100.0%
NZ_CP023075.1 and 7 others:
NZ_CP035393.1 Lanthipeptides: ES966_RS21105_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19665_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17705_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03370_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01895_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00520_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122700_lanthipeptide
Lanthipeptides: CK238_RS20695_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V Q I Y
39
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V Q I Y
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V Q I Y
39
92.3%
NZ_CP044444.1:
Lanthipeptides: F7V86_RS20970_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
89.7%
NC_023073.1 and 25 others:
NZ_CP010556.1 Lanthipeptides: SB45_RS19805_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19795_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20400_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22075_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS21000_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21480_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19740_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19585_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20470_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21110_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20035_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16480_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06705_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18975_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06485_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16830_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06200_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12895_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06150_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06335_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11720_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03045_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19745_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19365_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18850_lanthipeptide
Lanthipeptides: U722_RS20005_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K R L D A R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
with 3 more sequence matches
87.2%
NZ_CP025341.1:
Lanthipeptides: CXR48_RS19565_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K R L D R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D L R V
36
20.5%
NC_015600.1 and 17 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP024974.1 Lanthipeptides: CVO91_RS06555_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAMDIB010000004.1 Lanthipeptides: M5P35_RS04030_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
6
P N C K T G T D L T P V I K
19
P C K T G +T I K
9
P G C K T G I L M T C A I K
22
20.5%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
6
P N C K T G T D L T P V I K
19
P C K T G +T I K
9
P G C K T G A L M T C P I K
22

#### MIBiG 4.0 matches for GWK37_RS19665

12.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
6
P N C K T G
11
P C K T G
9
P G C K T G
14
allorf_3117293_3117475
Leader:
MKGGEIWNMKKNFSALYETSEQELKELVGG
Core:
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
Core with dehydrations:
Q N Dha V Dha I Dhb Dhb Y P I Dhb N H I Cys P Dhb I Dhb V G Cys A Cys P Q R Q V

#### antiSMASH-DB 4.0 matches for allorf_3117293_3117475

100.0%
NZ_CP016371.1 and 25 others:
NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide
Lanthipeptides: allorf_1203980_1204162_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
93.3%
NC_023073.1 and 18 others:
NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide
Lanthipeptides: allorf_1238739_1238921_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T P I T N H+C P T I T V G C A C P Q R Q V
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
66.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N +S I T T P T H+C T+T V G C A C P Q+Q+
1
Q N L I S I T T I P F T-H L C A T V T V G C A C P Q K Q I
29
with 3 more sequence matches
23.5%
NZ_CP048048.1 and 2 others:
NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptide NZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide
Lanthipeptides: GW571_RS15175_lanthipeptide
8
T Y P I T N H I C P T I T V G C A C P Q R Q
29
T+ +T +C T I A C Q
8
T F K L T V K V C R T I I T T T A C G S T Q
29
20.0%
NZ_JANIOB010000033.1:
Lanthipeptides: NQ113_RS28010_lanthipeptide
11
I T N H I C P T I
19
T N +C P T I
15
F T N R L C P T I
23
15.8%
NZ_KB907258.1:
Lanthipeptides: G358_RS0114910_lanthipeptide
2
N S V S I T T Y P I T N H I C P T I T
20
N S+ I+ Y + C P++
6
N S I R I S I Y K C L S L F C P S V A
24

#### MIBiG 4.0 matches for allorf_3117293_3117475

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
18
T I T V G C
23
T+T V C
18
T L T V E C
23
allorf_3123788_3123865
Leader:
MRIHSIFIRMQGLYA
Core:
Q V I C P T N A T Y
Core with dehydrations:
Q V I Cys P Dhb N A Dhb Y

#### antiSMASH-DB 4.0 matches for allorf_3123788_3123865

100.0%
NZ_CP016371.1 and 22 others:
NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide
Lanthipeptides: allorf_1210473_1210550_lanthipeptide
1
Q V I C P T N A T Y
10
Q V I C P T N A T Y
1
Q V I C P T N A T Y
10

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.27 out of 23.79
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 28.19
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.52 out of 24.78
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.07 out of 24.78
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.57 out of 20.01
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
Additional weak hits (1):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

GWK37_RS15585 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3892.7 Da
  Molecular weight: 3895.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3913.3 Da N = 1
GWK37_RS19655 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3403.7 Da
  Molecular weight: 3405.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3423.9 Da N = 1
    3442.0 Da N = 2
    3460.0 Da N = 3
    3478.0 Da N = 4
    3496.0 Da N = 5
    3514.0 Da N = 6
    3532.1 Da N = 7
    3550.1 Da N = 8
    3568.1 Da N = 9
GWK37_RS19660 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3389.7 Da
  Molecular weight: 3391.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3409.9 Da N = 1
    3427.9 Da N = 2
    3446.0 Da N = 3
    3464.0 Da N = 4
    3482.0 Da N = 5
    3500.0 Da N = 6
    3518.0 Da N = 7
    3536.1 Da N = 8
    3554.1 Da N = 9
GWK37_RS19665 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 4455.4 Da
  Molecular weight: 4458.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4476.2 Da N = 1
allorf_3117293_3117475 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3117.6 Da
  Molecular weight: 3119.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3137.6 Da N = 1
    3155.6 Da N = 2
    3173.6 Da N = 3
    3191.6 Da N = 4
allorf_3123788_3123865 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1072.5 Da
  Molecular weight: 1073.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1091.2 Da N = 1
GWK37_RS15585 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3892.7 Da
  Molecular weight: 3895.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3913.3 Da N = 1
GWK37_RS19655 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3403.7 Da
  Molecular weight: 3405.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3423.9 Da N = 1
    3442.0 Da N = 2
    3460.0 Da N = 3
    3478.0 Da N = 4
    3496.0 Da N = 5
    3514.0 Da N = 6
    3532.1 Da N = 7
    3550.1 Da N = 8
    3568.1 Da N = 9
GWK37_RS19660 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3389.7 Da
  Molecular weight: 3391.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3409.9 Da N = 1
    3427.9 Da N = 2
    3446.0 Da N = 3
    3464.0 Da N = 4
    3482.0 Da N = 5
    3500.0 Da N = 6
    3518.0 Da N = 7
    3536.1 Da N = 8
    3554.1 Da N = 9
allorf_3117293_3117475 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3117.6 Da
  Molecular weight: 3119.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3137.6 Da N = 1
    3155.6 Da N = 2
    3173.6 Da N = 3
    3191.6 Da N = 4
allorf_3123788_3123865 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1072.5 Da
  Molecular weight: 1073.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1091.2 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP048002.1 - Region 13 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,299,345 - 3,387,575 nt. (total: 88,231 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
GWK37_RS16675: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS16685: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS16690: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS16700: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS16730: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase
GWK37_RS16570: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

GWK37_RS16670: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase deformylase hydrolase phosphatase
GWK37_RS16650: hydrolase

smcogs
  SMCOG1179: hydrolase

GWK37_RS16655: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

GWK37_RS16705: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

GWK37_RS16710: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

GWK37_RS16740: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

GWK37_RS16770: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

Ligases: synthase
GWK37_RS16680: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

GWK37_RS16720: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.90 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.89 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.63 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.90 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.89 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.63 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
Additional weak hits (7):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.20 out of 31.73
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 16, location 3299344 - 3387575:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:
  GWK37_RS16675 + GWK37_RS16680 + GWK37_RS16685 + GWK37_RS16690 + GWK37_RS16695 + GWK37_RS16700 + GWK37_RS16705

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
GWK37_RS16670: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 92.6
  inactive: 32.0
  Methoxymalonyl-CoA: 28.0
  Methylmalonyl-CoA: 20.8
  Propionyl-CoA: 17.4
  fatty_acid: 13.9
  trans-1,2-CPDA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis

NZ_CP048002.1 - Region 14 - NRPS,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,611,616 - 3,721,730 nt. (total: 110,115 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
GWK37_RS17915: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

GWK37_RS18025: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS18045: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: acylase
GWK37_RS17985: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

GWK37_RS17990: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

GWK37_RS17995: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease
GWK37_RS17895: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

GWK37_RS17980: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

GWK37_RS18065: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase
GWK37_RS18010: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

GWK37_RS18015: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
GWK37_RS17920: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

GWK37_RS18005: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

GWK37_RS18020: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

GWK37_RS18030: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

GWK37_RS18035: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

GWK37_RS18040: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | T3PKS | NRPS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001089.5 |  |  |  |  | 1.63 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0001160.5 |  |  |  |  | 1.03 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0002135.2 |  |  |  |  | 1.03 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  |  |  |  | 0.97 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  |  |  |  | 0.96 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001833.4 |  |  |  |  | 0.96 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  |  |  | 0.96 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  |  |  | 0.95 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  |  |  | 0.94 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  |  | 0.91 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001089.5 |  | 0.91 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0002135.2 |  | 0.70 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.10 out of 24.78
Confidence: strong
Additional weak hits (17):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.06 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.38 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 17, location 3611615 - 3721730:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
GWK37_RS17985: mal
PKS_AT (4..285): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 98.2
  inactive: 51.6
  Methoxymalonyl-CoA: 36.5
  Methylmalonyl-CoA: 23.7
  Propionyl-CoA: 20.0
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

GWK37_RS17990: mal
PKS_AT (7..293): mal
ATSignature: (unknown)
No matches above 50%
minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 32.7
  inactive: 24.8
  Benzoyl-CoA: 13.9
  Methoxymalonyl-CoA: 12.4
  Isobutyryl-CoA: 8.8
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Methylmalonyl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

GWK37_RS17995: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 90.5
  inactive: 31.8
  Methoxymalonyl-CoA: 22.5
  Methylmalonyl-CoA: 9.4
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

GWK37_RS18020: fatty_acid - Gly
Search NORINE for peptide: strict or relaxed
CAL_domain (74..476): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 26.0
  NH2: 9.4
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (1145..1540): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
  Nearest Stachelhaus code(s):
    Gly DILQLGMIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS18035: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (492..896): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
  Nearest Stachelhaus code(s):
    Ala DVSNMAIIYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP048002.1 - Region 15 - NRPS,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,781,496 - 3,919,330 nt. (total: 137,835 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
GWK37_RS18495: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

GWK37_RS18510: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS18600: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

GWK37_RS18620: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

GWK37_RS18695: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

GWK37_RS18795: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase
GWK37_RS18595: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

GWK37_RS18640: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

GWK37_RS18655: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

GWK37_RS18665: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

GWK37_RS18685: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase
GWK37_RS18770: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

Lyases: hydratase
GWK37_RS18670: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
GWK37_RS18580: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

GWK37_RS18585: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

GWK37_RS18590: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

GWK37_RS18635: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

GWK37_RS18675: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

GWK37_RS18690: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

GWK37_RS18710: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

GWK37_RS18715: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

GWK37_RS18720: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

GWK37_RS18725: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

GWK37_RS18730: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | transAT-PKS | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001090.5 |  |  |  |  | 1.65 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001833.4 |  |  |  |  | 1.58 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  |  |  |  | 1.58 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001095.5 |  |  |  |  | 1.53 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0001128.4 |  |  |  |  | 1.50 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  |  |  | 1.49 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  |  |  |  | 1.49 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  |  |  | 1.48 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001098.5 |  |  |  |  | 1.47 | NRPS, PKS | iturin | Bacillus subtilis
BGC0001758.4 |  |  |  |  | 1.47 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001095.5 |  | 0.93 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0001090.5 |  | 0.92 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001098.5 |  | 0.84 | NRPS, PKS | iturin | Bacillus subtilis
BGC0000407.5 |  | 0.81 | NRPS | plipastatin | Bacillus subtilis subsp. subtilis
BGC0000402.4 |  | 0.80 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5 |  | 0.79 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.75 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002071.2 |  | 0.74 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.93 out of 29.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
Additional weak hits (12):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.46 out of 39.62
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.06 out of 29.38
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.27 out of 36.54
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 18, location 3781495 - 3919330:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 19, location 3781495 - 3858745:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 20, location 3841660 - 3919330:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
GWK37_RS18580: Ser - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (267..674): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1789..2188): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNNHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS18585: Tyr - Asn - Pro - Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (268..662): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
  Nearest Stachelhaus code(s):
    Tyr DALSVGEVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1779..2174): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3286..3683): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4325..4732): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS18590: fatty_acid - Asn
Search NORINE for peptide: strict or relaxed
CAL_domain (36..478): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 621.2
  NH2: 18.0
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (2956..3351): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS18595: mal
PKS_AT (6..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 79.7
  inactive: 29.9
  Methoxymalonyl-CoA: 21.9
  Methylmalonyl-CoA: 13.0
  Propionyl-CoA: 11.7
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

GWK37_RS18690: X
AMP-binding (12..445): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
  Nearest Stachelhaus code(s):
    Z-ahmohOrn FGLHIASTCK (56% 8Å match)
    Ile DGLFIGIPVK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

GWK37_RS18710: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (473..866): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
  Nearest Stachelhaus code(s):
    Ile DAFFYGITFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS18715: Pro - Gln - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (469..866): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1901): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
  Nearest Stachelhaus code(s):
    Gln DAWHFGSVEK (100% 8Å match)
    Glu DAWHFGSVEK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2532..2924): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
  Nearest Stachelhaus code(s):
    Tyr DGTITAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS18720: Glu - X
Search NORINE for peptide: strict or relaxed
AMP-binding (468..873): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1505..1898): X
nrpys: Ala, Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSSFDVTTFEGWLIIGGEWNGYGPTENTTFSTC
  Nearest Stachelhaus code(s):
    Ala or Val DVFWIGGTFK (97% 8Å match)
    Val DVFWIGGTFK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS18725: Tyr - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (474..867): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGSLTSTLITFAGELNEYGPTENSVATTI
  Nearest Stachelhaus code(s):
    Tyr DGTLTAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1509..1905): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHKHFDFSVWEGNQVFGGEVNMYGITETTVHVTC
  Nearest Stachelhaus code(s):
    Thr DFWNVGMVHK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

GWK37_RS18730: Glu - Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (463..868): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1905): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    AAWAFDVFSGDRESVLGSDINSYGVTEATIDSSY
  Nearest Stachelhaus code(s):
    Orn DVGEVGSIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CcpA | Catabolite control protein A
GnfM | Regulator of nitrogen-fixation genes
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP048002.1 - Region 16 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,942,860 - 3,964,743 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
GWK37_RS19025: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase
GWK37_RS19050: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.46 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.46 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
GWK37_RS19030: T2TS
Domain 1 (5 - 625): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.30 out of 27.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
Additional weak hits (5):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.54 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor