LOCUS       NZ_CP025249            21218 bp    DNA     circular CON 17-MAR-2024
DEFINITION  Actinomyces sp. 432 chromosome, complete genome.
ACCESSION   NZ_CP025249
VERSION     NZ_CP025249.1
KEYWORDS    RefSeq.
SOURCE      Actinomyces sp. 432
  ORGANISM  Actinomyces sp. 432
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 3141809)
  AUTHORS   Zhu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2017) National Institute for Communicable Disease
            Control and Prevention, Chinese Center for Disease Control and
            Prevention, No. 155 Changbai Road, Changping District, Beijing
            102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: other v. HGAP 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009930875.1-RS_2024_03_17
            Annotation Date                   :: 03/17/2024 01:42:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,736
            CDSs (total)                      :: 2,675
            Genes (coding)                    :: 2,520
            CDSs (with protein)               :: 2,520
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 125 of 155
            Pseudo Genes (incomplete)         :: 36 of 155
            Pseudo Genes (internal stop)      :: 2 of 155
            Pseudo Genes (multiple problems)  :: 7 of 155
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:53:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1640640
            Orig. end                         :: 1661858
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025249.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21218
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21218
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21218
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11218](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11218
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    58..76
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            complement(419..1372)
                     /locus_tag="CWT12_RS06840"
                     /old_locus_tag="CWT12_06790"
     CDS             complement(419..1372)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023955.4"
                     /locus_tag="CWT12_RS06840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06790"
                     /product="DUF3737 family protein"
                     /protein_id="WP_337247882.1"
                     /transl_table=11
                     /translation="MPRCEDVGFLESCAMTLAATPAAPTDCLGNSDSMVDHQHLTGERA
                     LYASRDLTIVHSTFSDGESPLKESRGLRISDSVFEWKYPLWYCQDVSVTGGALLETARS
                     GIWYTDDIRIEGTLVAAPKTFRRGRGISLQRVDLPHAEETLWSCREVTLAEVNATGDYF
                     AKDAVGVTAERLRLTGNYAFDGARDVTVRDSVLLSKDAFWNCENVVVENSVIVGEYLGW
                     NSRNVTLVDCTVQSLQGLCYIDGLTLRGCRLLDTTLAFEYCRGIDAEIIGHLDSLTNPY
                     DGVIRVGSIGEKIFDPDRVKPAATRIETGWTPLVDA"
     misc_feature    complement(1322..1324)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1551..2603)
                     /locus_tag="CWT12_RS06845"
                     /old_locus_tag="CWT12_06795"
     CDS             complement(1551..2603)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008733836.1"
                     /locus_tag="CWT12_RS06845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06795"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_161924222.1"
                     /transl_table=11
                     /translation="MTPVYGSTPRTGPGGPWAMFRPGPRSALPRMLTWSPLGPRDNAEL
                     ADLVARSEAADNPPYRTTAQETAEYFVDPTYSGVAGRDADGVMRAFGLVRLRPAGEIYA
                     SMTGTVDPAWRRRGIGVALLHWQTERARHLIGAERAGEPSGSAASAPAHIVTTVLEDDE
                     RMKDHLLELRFEPRRWYREVRRSLATAIPTVELDGFLGIEPWSEDLDDAVRRAHNQAFA
                     DSGGGSMSPEEWRAGRAYFAPQWSFVALDRSGDRARVAGYVLSSRYEQDWEALGWREGY
                     TDVIGVLADYRSRDVGPALLCAAMRAYAADGMEYAAAGFESDDPSGAVDLFRDLGYTAT
                     RGTILYGLDV"
     gene            complement(2753..4972)
                     /locus_tag="CWT12_RS06850"
                     /old_locus_tag="CWT12_06800"
     CDS             complement(2753..4972)
                     /EC_number="5.6.2.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006549607.1"
                     /locus_tag="CWT12_RS06850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06800"
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="WP_161924223.1"
                     /transl_table=11
                     /translation="MPDSSQSYSARHLSVLEGLEAVRKRPGMYIGSTDQRGLMHCVWEI
                     IDNGVDEALEGYGDRIDVLVHADGSIEVRDTGRGVPVDVEPSSGLTGVELVYTKLHAGG
                     KFGGGSYGSAGGLHGVGASVVNALSARMDVEVDRGGKTYAMSFRRGVPGVFTDPTTGPN
                     PDAPFEEYTEATQLRVVGKVRRGVTGTRVRYWADPEIFPAPAQYDITALRARLRQTSFL
                     VPGLTLTLTDERDPEAVAAAASGPAAGDPALSAKAAHASAGAGDLFTSGAADQEGAEVF
                     HAEGGTADFVDFLATDGSVTDTFRLTGEGTYTETVQQLDQRTGHLRPTEVERTCTVDVA
                     LRWGIGYDTTERSFVNIIATPMGGTHLTGFEQAVTKVLRKQIDANSRALKVTSRDGRIE
                     KDDILAGLTAVITVRVPEPQFEGQTKEVLGTAPVRQIVAKVVEKELTALLTSSKRDLKT
                     QSRALQEKIVGEMRARVSARMHKEITRRKTALETSTLPAKLADCRSDDVASSELFIVEG
                     DSALGTAKNARNSEFQALLPIRGKILNVQKASQADMLRNAECSAIIQVVGAGSGRTFDL
                     EAARYGKVILMTDADVDGAHIRTLLLTLFFRYMRPMIEAGRVFAAVPPLHRIEVSAQGR
                     RKKEVIYTYSDEELVTTLRKLEKQGRSFKEPQRYKGLGEMDAHQLAETTMEPEHRTLRR
                     ITLSDEAELAEAENVFELLMGSSVEPRRDFIIEGAADIDRERIDA"
     gene            5175..5453
                     /locus_tag="CWT12_RS06855"
                     /old_locus_tag="CWT12_06805"
     CDS             5175..5453
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003780431.1"
                     /locus_tag="CWT12_RS06855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06805"
                     /product="hypothetical protein"
                     /protein_id="WP_161924224.1"
                     /transl_table=11
                     /translation="MSTATPISTTVADPTAVPEQATGQAAATETRPLTTADRCDVCGAQ
                     AYLRVVLASGELLFCAHHGHAHRDALERQALFIQDESDRLTRSNESD"
     gene            complement(5458..6312)
                     /gene="thiD"
                     /locus_tag="CWT12_RS06860"
                     /old_locus_tag="CWT12_06810"
     CDS             complement(5458..6312)
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /GO_function="GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005962557.1"
                     /locus_tag="CWT12_RS06860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06810"
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="WP_161924225.1"
                     /transl_table=11
                     /translation="MTSTIPRVLTVAGSDPSGGAGVQADLKTMGALGAYGMSVVTALTA
                     QSTRGVTGVHAVPVDFVRLQLDTLLADIAPDATKIGMLATAELADAVGEYLPGLPGTVL
                     DPVMVATSGDRLLDADALAALRRLCMRADLITPNLPEAAALLGCEPATSPDEMRRQAEA
                     LLARGARRVLLKGGHLAGGAADVYADTDSTVLLPGRRVRTRNTHGTGCTLSSAVAALRP
                     QRDSWIAAVRDAKAYLTGALAHADLLGVGHGHGPVHHYYALWPTQPEGVGRKLKDPTGE
                     PPA"
     gene            complement(6309..6689)
                     /locus_tag="CWT12_RS14355"
     CDS             complement(6309..6689)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014622.4"
                     /locus_tag="CWT12_RS14355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_272927744.1"
                     /transl_table=11
                     /translation="MGQRDLPATVVRELIGEAAYLGLSAATPEELSAAESEGACDHVGI
                     GAVRATATKTDAPAGIGTGGVIRLAASAGLPCVAIGGVTSADLPVLRAGGLAGAAVVSA
                     ICLADDPREAAQQLRGAWESGQ"
     gene            complement(<6782..6964)
                     /locus_tag="CWT12_RS14360"
                     /pseudo=""
     CDS             complement(<6782..6964)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014622.4"
                     /locus_tag="CWT12_RS14360"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="thiamine phosphate synthase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRPAPDLRVYLVTDADQCRSRGRTVTDTVRAAVAGGVTCVQVRAK
                     HADGAGFLAQVLGVAH"
     gene            complement(6961..7833)
                     /gene="thiM"
                     /locus_tag="CWT12_RS06870"
                     /old_locus_tag="CWT12_06820"
     CDS             complement(6961..7833)
                     /EC_number="2.7.1.50"
                     /GO_function="GO:0004417 - hydroxyethylthiazole kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017178454.1"
                     /locus_tag="CWT12_RS06870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06820"
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="WP_161924226.1"
                     /transl_table=11
                     /translation="MPQHASASAYSSDCPAEPSVLRAPAPPAGTAEVLESLRAAGPLVA
                     CITNSVVTNFTANVLLATGAAPAMVDVTGEAGPFAAVASALLINLGTPQPEQRAAALEA
                     AAAARAAGVPWVLDPVAVGTLVHRTELAHRLLEEEPTVIRGNASEIMALAGSGAGGRGV
                     ETADDVAAALGAARALSARTGAVVAVSGPVDAIVDDGRLARVGGGSALLTRVTGGGCAL
                     GALAAGFLAAGRAIGTDAFAATVACHAVYSAAAEIAAETAAGPGSFQVALLDSLYCLDA
                     DDLARIPVS"
     regulatory      complement(7823..7910)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(7994..9670)
                     /locus_tag="CWT12_RS13920"
                     /old_locus_tag="CWT12_06825"
     CDS             complement(7994..9670)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009747452.1"
                     /locus_tag="CWT12_RS13920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06825"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_161924227.1"
                     /transl_table=11
                     /translation="MATSTVAPTPTTRRERVELADDVDEVLDGNQDVDLDEEDDLDAED
                     DLDAEDDDEADYDEDDYADADDVQDVDEDDVDTQGDDAAPAPELRDYYLDVSLEENGDG
                     TKRRPFNTPAALKDVQLAPGATLFVRSRTVVEGLEISGDGTLEEPITLAPYGHGPVPRF
                     IVPGEEEPVVAREFLTKNGYIFRGWVIKGIKMSPSIAALTGELERMRREEAEKAAGKKT
                     KKSKGEKSKDGSFTVSDSDEGDEPAQKVVTAGATADPVKDYLKQIGKVALLNAAQEVEL
                     AKRIEAGLYAEHLLATEGNDLDAKYRRELHWVAQDGQRAKNHLLEANLRLVVSLAKRYT
                     GRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPV
                     HMVEVINKLARVQRQMLQDLGREPTPEELAVELDMTPEKVVEVQKYGREPISLHTPLGE
                     DGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHAVLDTLSEREAGVVSMRFGLTDGQPKT
                     LDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLDD"
     gene            10001..11218
                     /locus_tag="CWT12_RS06880"
                     /old_locus_tag="CWT12_06830"
     CDS             10001..11218
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003780414.1"
                     /locus_tag="CWT12_RS06880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06830"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_161924228.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.7e-37, bitscore:
                     124.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVDALLPLVRSAVDARLEHVLGELRARWHDPSGAADDLFDAAA
                     TAVSGGKRMRAVLGAVGLALLTQDGAASGDRGRGGCRSGNRDESRPEPPRREDVLTGST
                     AAYLGAALELYQASALVHDDVIDAADTRRGLPSAHRRFAARHLENGWRGAAENYGVSAA
                     ILLGDLLMSAAASEMGAAAAACGPCAGRAGRDAFDAMTTEVAVGQFLDVHHEVLPLPAP
                     TAQPVQAGAAMHRAALAVVRHKSARYSVMYPLLVGALLAGVDPHSELFRVLEVFGEEIG
                     IAFQLRDDVLGVFGDPSLTGKPAGDDLREGKRTVLLALTWQRCSDADRALLTRVLSRGH
                     AAADEDIAAATEVIRDCGALTAHEEEIASHTAAGLGALAASPATLNDVARQSLTALAEV
                     LTSRRS"
     gene            11319..13370
                     /gene="pknB"
                     /locus_tag="CWT12_RS06885"
                     /old_locus_tag="CWT12_06835"
     CDS             11319..13370
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009749748.1"
                     /locus_tag="CWT12_RS06885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06835"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_161924229.1"
                     /sec_met_domain="Pkinase (E-value: 9.1e-47, bitscore:
                     156.9, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDPLIGRLVDARYEIVDRVARGGMATVYRAQDRRLDRLVALKL
                     MHPHLADSPDFVARFRREARAAARLSNPGVVAVYDQGSLDGVAYLVMELVEGPNLRDLI
                     AAGPLTVREALGLTAQVLRPLGAAHRAGLVHRDVKPENVLLPADGSVAKVADFGLARAV
                     TEVTQTTTGNVLGTVAYLAPELITTGSSAPCADVFSVGVILYELLTGAQPFTAETPIQI
                     AFRNVHEDVPAPSERLPDLAQSVDALVAQMTRRAPEERLADADAALSRLRQVVSALSDA
                     ELAVKRGGATGSVRTQEVLAANAEAAHTAMLAADGDASEPDDAQVPADAATPGAGLRTV
                     SLPIGSIAPDEDSESRDGTTRALDRRQAVRAGSQEETARVARHSARRPRRRALVAAGLV
                     LLTAGGAGAWYFGAGPGRTVPVPQIAGMTAAEAQALVESAGLVWGAPTRAYSDTVPADS
                     VISSSPEAATRMHPGEAVTPVISRGIEQKTVPDVVGSSQDDATTAITDAGLSLGAVTKT
                     YSDSVASGMVISSEPVAGTTVNHSSAVAIVVSLGRQPAVVPDVTGMSVDDATTTLQAAG
                     LTLGTQSEAFSDDVASGLVISSSPASGAEGYYHGDAVDVTVSKGPEMVNVPDVAGMSEQ
                     EATAALQEVGLEVEVSRVLGGLFGTAHSTDPAAGESVRKGSKVTLNVV"
     misc_feature    11338..11353
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.61"
                     /tool="antismash"
     gene            complement(13498..14838)
                     /locus_tag="CWT12_RS06890"
                     /old_locus_tag="CWT12_06840"
     CDS             complement(13498..14838)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004565051.1"
                     /locus_tag="CWT12_RS06890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06840"
                     /product="3-deoxy-7-phosphoheptulonate synthase class II"
                     /protein_id="WP_161925345.1"
                     /transl_table=11
                     /translation="MNELQVPGEAAGWRQHHAAQQPHYPDPQALADAAADLRTRPPLVF
                     AGEVDSLREKMVSASQGRAFVLMGGDCAESFHDNTAINIRLKLQTILQMAAVLTYGAST
                     PVVKIGRMAGQYAKPRSSDTETRNGVTLPSYRGDSVNDHAFTAEARIPNPQRMVDAYLR
                     AGTTLNLIRSFTMGGYADLREVHSWNRGFTANPAYKRFESFAGEIDRAMRFMEAAGVDF
                     EALRQVDFYAAHEALLLEYEDAMTREDSRSGRLYDTSAHFLWVGERTRGADDAHVALLA
                     GVHNPVGVKIGPTTTREELLSLIDHLNPEGDPGRLSLITRMGADRIRDVLPELVEIVRA
                     DGRPVTWITDPMHGNTITSENGYKTRRFDTIMDEVRGFFEVHRALGTVPAGIHVELTGD
                     DVTEVLGGGEHIDEAGLARRYETLVDPRLNHQQSLEMAFEVAEMLRG"
     gene            complement(15069..16301)
                     /locus_tag="CWT12_RS06895"
                     /old_locus_tag="CWT12_06845"
     CDS             complement(15069..16301)
                     /EC_number="2.7.1.90"
                     /GO_process="GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005985403.1"
                     /locus_tag="CWT12_RS06895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06845"
                     /product="pyrophosphate--fructose-6-phosphate
                     1-phosphotransferase"
                     /protein_id="WP_161924230.1"
                     /transl_table=11
                     /translation="MSIRRVALLTAGGFAPCLSAAVGDLIERYTEVAPDVEIIAYQYGY
                     HGLLTGNYVVIDDEGRKNAGVLRQYGGSPIGNSRVKLTNAKNLVERGLVKEGVDPLAFA
                     AERLREDGVDVLHTIGGDDTNTTAADLAAYLHEHDYDLTVVGLPKTIDNDVVPIRQSLG
                     AWTAAEQGAGFALNVIGEHRSNPRMLIVHECMGRNCGYLTAETARRYHELLKDRQWAPS
                     LGLTQERWDVHAVFVPEAKLDIAAEAERLKAIMDEQGNVNIFLSEGAGVPEIIAEMEAR
                     GEEVQRDPFGHVKLDTINPGQWFARQFAEKIGAEKVMVQKSGYYSRASAANEEDLALIK
                     QMCDLAVDCALRGEPGVIGQDEENGDQLGAIAFDRIAGGKPFDITQQWFVDLMAELGQA
                     LEPAAPADGEA"
     gene            16519..16980
                     /locus_tag="CWT12_RS06900"
                     /old_locus_tag="CWT12_06850"
     CDS             16519..16980
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024252.4"
                     /locus_tag="CWT12_RS06900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06850"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_202616161.1"
                     /transl_table=11
                     /translation="MTQRTEREWIRFRRHAAGLSQRELADRTGVSQPLIAAIESGARRA
                     SRSTLQRLTQALQVRPSDLLHAARQDVIELAAAHGCQVIGVFGSVASGTDRQDSDIDLI
                     VRFPEHADILDLLELEEELSDLLTVPVDVISASSGSVAMSGTSLEPVRI"
     gene            16977..17327
                     /locus_tag="CWT12_RS06905"
                     /old_locus_tag="CWT12_06855"
     CDS             16977..17327
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014043.4"
                     /locus_tag="CWT12_RS06905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06855"
                     /product="HepT-like ribonuclease domain-containing protein"
                     /protein_id="WP_161924232.1"
                     /transl_table=11
                     /translation="MSTTSPSADRTERRLADLRRFGDEAAFIVSHGFDAYAADSMEGAL
                     LRNAGERVLIKVATVVEKLPREYKEQFPDVDWVGIMRMRNLVAHHYDKVNDDLMFRALE
                     VRIPGLLTALGL"
     gene            complement(17539..17799)
                     /locus_tag="CWT12_RS06910"
                     /old_locus_tag="CWT12_06860"
     CDS             complement(17539..17799)
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]"
                     /GO_function="GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]"
                     /GO_process="GO:0051290 - protein heterotetramerization
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016876.4"
                     /locus_tag="CWT12_RS06910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06860"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_237564068.1"
                     /transl_table=11
                     /translation="MPYAIALAARAKRDLRSHPEKVVTAVVEFLYGPLRDNPYRVGKPL
                     RFELAGLHSARRGDYRIIYRIDDDARRVVVVTVDHRSDGYR"
     gene            complement(17804..18085)
                     /locus_tag="CWT12_RS06915"
                     /old_locus_tag="CWT12_06865"
     CDS             complement(17804..18085)
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014643.4"
                     /locus_tag="CWT12_RS06915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06865"
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="WP_202616162.1"
                     /transl_table=11
                     /translation="MSVDAVMPLRDVKNHLSEVVGQVEREHSRVTITRHGRPAAVVISA
                     DDLESLEETLGILSRPALIERIRAGVDDLGAQRVEVLSKDELLDSPKG"
     misc_feature    complement(18085..18098)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.37"
                     /tool="antismash"
     gene            18165..18773
                     /locus_tag="CWT12_RS06920"
                     /old_locus_tag="CWT12_06870"
     CDS             18165..18773
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="CWT12_RS06920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06870"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_161924234.1"
                     /transl_table=11
                     /translation="MRRTAAEAAETRQAIIRSALHRFAKDGWEACSLVEVARGADVTRG
                     AVYHHFTGKRELLDAALSEQWHSQGEALLAALDASTAPEVRLTAFLADYLRRLRGDTAF
                     RELAVVTVLVAPQAPAVKSGLEQKTAALAQWSALLIGVLTECEERLRAPLDIARFNIAS
                     FLYGATLTAALTPEDLPASGCCEATARALVAGLITVESP"
     gene            18806..19054
                     /locus_tag="CWT12_RS13925"
     CDS             18806..19054
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWT12_RS13925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_237564069.1"
                     /transl_table=11
                     /translation="MHPSSTEAATNPHVAVTVACVALFTDMLVYGILIPVLPLLPAVAE
                     AGASATGLLFAAYAAALVIVTPLAGRVVDRHGPADRC"
     gene            19063..19740
                     /locus_tag="CWT12_RS06925"
                     /old_locus_tag="CWT12_06875"
     CDS             19063..19740
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="CWT12_RS06925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06875"
                     /product="MFS transporter"
                     /protein_id="WP_237564070.1"
                     /transl_table=11
                     /translation="MGLACACLLFTIGGPYWLLLTARTLQGAAAGLSWVAGLSLIAGTV
                     PLRQRGTYLGLAMSMVSVGVLAGPPLAGWLARFGGHSAPFLCAIVLLAIDGGLRVAFVR
                     PTPPPDDDPATAMDVLRTPGCRPVVALILFGAAAAAVGLVLVGIGPNYPVIIAGLMCLG
                     VAIALLVVPAGALIGVQGAIATPPTIGGAYSLYNLAYAGGLVLGPAATILARLPSRFAV
                     MPG"
     gene            complement(19889..20806)
                     /locus_tag="CWT12_RS06930"
                     /old_locus_tag="CWT12_06880"
     CDS             complement(19889..20806)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009405632.1"
                     /locus_tag="CWT12_RS06930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CWT12_06880"
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_161924235.1"
                     /transl_table=11
                     /translation="MGYRGIKAAVGPAMEMLYQPWIRGEENIPAEGPAILASNHLAVID
                     SFFLPLLMDREVAFIGKSDYFTGKGIKGWAVKNFMTAVGTIPVDRSGGKASMAALQAGI
                     DRLRSGELFGIYPEGTRSPDGRLYRGKTGVARVALATGAPVIPVAMIGSNLAQPIGQVV
                     PSTRHRVGIVVGEPLDFSRYQGLENDRFVLRSITDEIMYALMSLSGQEYVDLYAADVKK
                     AMDAEKKTAAEVVDEMLEELAAKRPAAAPVEAPGGRPAPDVEVPEPPAEPDEAEEEEEV
                     EDIEGAPEGDEGVAPDAESRSDDH"
ORIGIN
        1 tgccgcaggt cgctggtgac caagcgccga ccgttgttca ggacgctgtt ggtgaagatg
       61 ttgtagacgg gctgctgaat cacaaccttc tcgaacacat tggtcacgct gcgaacgatc
      121 gaggagatcg cggcgacgac ccccgtggta gggatcaacc agtcacgctg tagcggccag
      181 ccgtggcggc gtgtccacca gtcggttacg gcctgctcgt aggcgtcggt gacgacggtg
      241 tagcccagca ggccctcgcg ggcaacacgg gcgagtgccc ggcgcacgac gggcgcggtg
      301 cgcaggtcca tgtccgcaac ccacatgggc agctcaccgg gcccggcctt atcccatttt
      361 agtgaaccgg tgccacgccg gtcggtgcac tcgtccaggt tgaagttgga ggaggagctc
      421 atgcgtctac caggggcgtc cagccggttt cgatgcgggt cgcggcgggt ttcactcggt
      481 ctgggtcgaa gatcttctcg ccgatggagc cgaccctgat tacgccgtcg taggggttgg
      541 tcagtgagtc gaggtgaccg attatctcgg cgtcaatgcc ccggcaatac tcaaaggcga
      601 gagtggtgtc caacagacgg cagccccgca gggtgagtcc atcgatgtag cacaggccct
      661 gcagactctg aacggtgcag tcgacgaggg tgacgttgcg agagttccag cccaggtact
      721 cccccacgat caccgagttc tccaccacca cattctcaca gttccagaag gcgtccttac
      781 tcagcagcac actgtcccgt acggtcacgt cccgcgcccc gtcgaaggcg tagttcccgg
      841 tgagccgcag ccgttcggca gtcaccccga cggcgtcctt ggcgaagtag tcgccggtgg
      901 cattcacctc cgctagcgtc acttcccggc agctccacag ggtttcttcg gcatgtggca
      961 ggtccacccg ctgcaggctg ataccgcggc cgcggcggaa ggtctttggt gcggccacca
     1021 gcgtgccttc aatgcggatg tcgtccgtgt accagatgcc ggagcgggcg gtctccagca
     1081 gagcgccgcc ggtgaccgac acgtcctggc agtaccagag cggatacttc cactcgaaca
     1141 cgctgtcgct gatacgcaga ccgcggctct ccttaagcgg ggattcaccg tcgctgaatg
     1201 tggagtggac gatggtcaga tcgcgagagg cgtacagcgc gcgttcgccg gtcaagtgct
     1261 gatggtcgac catcgagtcg ctgttgccga gacagtcggt cggtgctgct ggggttgcgg
     1321 ctaatgtcat ggcacacgac tctaggaagc cgacgtcctc gcaacgaggc attatcagta
     1381 cctgtcagcg atctcctctt catcgtgccg gctccgagtc cgaacaggtg caggccgtct
     1441 ccacgacgtc gcctccggca ggggagcatc ggacccggcg ggagcccgat gcgatccagc
     1501 cgatgtcaac cccggtgctg cgggcggagc caacgcgcgg gaatcggcgc ctacacgtcc
     1561 aagccgtaga ggatggtccc ccgggtggcg gtgtaaccca ggtcgcggaa caggtcgacg
     1621 gcgccgctgg gatcgtctga ctcgaagccc gcggcagcgt actccatgcc gtcggccgcg
     1681 taggcgcgca tggccgcgca cagcagcgcc gggcccacgt ccctggaacg gtagtcggcg
     1741 agcacgccga taacgtccgt gtaaccctcc cgccagccga gtgcctccca gtcctgctca
     1801 tagcggctgg acagcacgta gccggccacg cgcgcacggt ccccggaccg gtccagcgcc
     1861 acgaagctcc actggggggc gaaataggca cgcccggccc gccactcctc cgggctcatg
     1921 ctgccgccgc cggagtcggc gaaggcctgg ttgtgggctc ggcgcacggc atcatccagg
     1981 tcctccgacc acggctcgat accgaggaac ccatccagct caaccgtggg tatcgcggtg
     2041 gccaatgagc gcctgacctc ccggtaccag cggcgcggct cgaagcgcag ctccaagagg
     2101 tgatccttca tgcgttcatc gtcctctagg accgtggtga cgatgtgcgc tggcgcggag
     2161 gcggccgatc cggacggctc acctgcccgt tcggcaccga tgaggtgccg ggcccgctcg
     2221 gtctgccagt gcagcagcgc cactccgatg ccgcgcctac gccaggcagg gtctacggtc
     2281 ccggtcatgg aggcgtagat ctcccccgcc ggacgcagcc gcaccagccc gaatgcgcgc
     2341 atcacaccat cggcgtcgcg cccggccaca ccggaatagg tggggtctac gaagtactcg
     2401 gcggtctcct gcgcggtggt gcggtagggc gggttgtcgg cagcctcaga gcgggcgacc
     2461 agatcggcga gctcggcatt atcgcgaggt ccaagcggcg accaggtgag catgcggggc
     2521 aaggcggacc ggggaccggg acggaacatg gcccaggggc cacccggacc ggtgcggggc
     2581 gtcgaaccgt aaaccggcgt catatgcgtc tccttcgacg ggacggtgcc cgacctcggg
     2641 cctggacgga tcagatgttg gatgaagcgg gtcgctccag gttacccgag cagcccaccc
     2701 gcaccgcgtg ccgtcggcgc ggaggcgtca ccggcggcgg gcctccggag cctcaggcgt
     2761 cgatgcgctc gcggtcgatg tcggcggcgc cctcgatgat gaagtcgcgg cgcggctcca
     2821 cgctggagcc catgagcagc tcaaacacgt tctccgcctc ggcgagctcg gcctcgtcgc
     2881 tcagggtgat gcgccgcagg gtgcggtgct ccggctccat cgtcgtctcg gccagctggt
     2941 gggcatccat ctcccccagg cccttgtaac gctggggctc cttgaagctg cgcccctgct
     3001 tctccagctt gcgcagggtg gtgaccagct cctcgtcgga gtaggtgtag atgacttcct
     3061 tcttgcgtcg tccctgggcg gatacctcga tccggtgcag cgggggcacg gcggcgaaga
     3121 cgcggccagc ctcgatcatg gggcgcatgt agcggaagaa cagggtcagc agcaaggtgc
     3181 ggatgtgggc gccgtcgacg tcggcgtcgg tcatcaggat gaccttgccg tagcgggcgg
     3241 cctccaggtc gaaagtgcgt ccggaaccag cgccgaccac ctggatgatg gcggagcact
     3301 cggcgttgcg cagcatgtcc gcctgggacg ccttctgcac gttgaggatc ttgccgcgga
     3361 tcggcagcag cgcctggaac tcgctgttgc gagcgttctt ggcggtgccc agggcggagt
     3421 cgccctcgac gatgaacagc tcggaggagg cgacgtcgtc ggagcggcag tcggccagct
     3481 tggcgggcag cgtggaggtc tccagggcgg tcttgcggcg ggtgatctcc ttgtgcatgc
     3541 gggcggacac gcgtgcgcgc atctccccga cgatcttctc ctgcagggcg cgcgactggg
     3601 tcttcaggtc gcgcttggag gaggtcagca gggcggtgag ctccttctcc accaccttgg
     3661 cgacgatctg gcgcaccggg gcggtgccga gcacctcctt ggtctgtccc tcgaactggg
     3721 gctcgggcac gcgcacggtg atgacggcgg tcagccccgc caggatgtcg tccttctcga
     3781 tgcgcccgtc gcggctggtg accttcaggg cgcgggagtt ggcgtcgatc tgcttgcgca
     3841 gcaccttggt gacggcctgc tcaaagccgg tcaggtgggt gccgcccatg ggggtggcaa
     3901 taatgttgac gaaggagcgc tcggtggtgt cgtagccgat gccccagcgc agggccacgt
     3961 ccacggtgca ggtgcgctca acctcggtgg ggcgcaggtg tccggtgcgc tggtcgagct
     4021 gctgcacggt ctcggtgtag gtcccctcgc cggtaaggcg gaaggtatcg gtaacggagc
     4081 cgtcggtagc caggaagtcg acgaagtccg cagttccgcc ctcggcgtgg aagacctcgg
     4141 cgccctcctg gtccgcggcg ccggaggtga acaggtcgcc cgcacccgct gaggcgtggg
     4201 cggccttggc gctcagcgcc gggtcgccgg ccgcaggacc gctggccgcg gcggcgacgg
     4261 cctccgggtc gcgctcatcg gtgagggtca gcgtgagccc gggcaccagg aagctggtct
     4321 gccgcagccg ggcgcgcagg gcggtgatgt cgtactgggc gggtgcgggg aagatctcgg
     4381 ggtcggccca gtagcgcacc cgggtgccgg ttacgccccg gcgcaccttg ccgaccacgc
     4441 gcagctgcgt ggcctcggtg tactcctcga agggcgcatc tgggttgggg cccgtggtgg
     4501 gatctgtgaa gacgccggga acgccgcgcc tgaagctcat ggcgtaagtc ttaccgccgc
     4561 ggtccacctc cacgtccatg cgggctgaca gggcgttgac cacgctggcg cccaccccgt
     4621 gcaggccgcc ggcggagccg taggagccgc cgccgaactt cccgccggcg tgcagcttgg
     4681 tgtagaccag ctcgacgccg gtcagcccgg aggagggctc cacgtccacg ggcacacccc
     4741 gaccggtgtc gcgcacctca atggacccgt cggcgtggac caacacgtca atgcggtccc
     4801 cgtagccctc cagggcctcg tccacgccgt tgtcgatgat ctcccacacg cagtgcatca
     4861 ggccccgctg gtcggtggag ccgatgtaca tgccagggcg cttgcgcacc gcctcaagcc
     4921 cctccagcac ggagaggtgg cgggcggagt aggactggga agaatctggc acggcccgaa
     4981 tctagccgat tgccggggcg gcttcggcgc cccgcgccgc cgccgggatg tggtcttcgc
     5041 ccggcgccga cgcgtcgacg ccacccctga ttcccgtgat tccctgcgtt cgccgtgggc
     5101 gcagggggtg cgcccggggc ggaaaacggc ccttcagcgt tggcgcgggc gcccagcggt
     5161 ggtgaaatcg agccatgagc accgcaactc ctatctccac cacggtcgcc gatccgacgg
     5221 ccgtgcccga acaggccacc ggccaggccg cggcgaccga gacgcgtccg ctcaccaccg
     5281 ccgaccgctg tgacgtctgc ggcgcgcagg cctacctgcg cgtggtcctc gcctccggcg
     5341 agctgctgtt ctgcgcccac cacggccacg cccaccgtga cgccctggag cgccaggccc
     5401 tgttcatcca ggacgagtcc gaccgcctca cccgctcaaa cgagtccgac tgaccgacta
     5461 ggcgggcggc tcgcccgtcg gatccttcaa ctttctgcct acgccctctg gctgagtcgg
     5521 ccagagggcg tagtagtggt gcaccgggcc gtgcccgtgg ccgacaccga gcaggtcggc
     5581 gtgcgctagg gcgccggtca ggtaggcctt ggcgtctcgt accgccgcga tccagctgtc
     5641 acgctgcgga cgcagggcgg cgacggcgga cgacagcgtg cagcccgtcc cgtgggtgtt
     5701 gcgggtgcgc acgcggcgac ccggcagcag caccgtgctg tcggtgtcgg catacacgtc
     5761 ggctgcccct cccgccaggt ggccgccctt gagcagcacc cggcgagccc cgcgggcgag
     5821 cagcgcctcg gcctggcggc gcatctcgtc ggggctcgtg gcgggctcgc atcccagcag
     5881 cgcggccgcc tccggcaggt tcggcgtgat cagatccgcc cgcatgcaca ggcggcgcag
     5941 cgccgccagg gcgtcggcgt cgagcaggcg gtccccggag gttgccacca tcaccgggtc
     6001 caggacggtt ccgggcagac cggggaggta ctcccccacc gcgtcggcca gctcggcggt
     6061 ggcgagcatg ccgatcttgg tggcgtcggg ggcgatgtcc gccagcaggg tgtccagttg
     6121 caggcgcacg aagtccacgg gtacggcatg caccccggtt accccgcgcg tggactgagc
     6181 ggtcagtgcg gtgaccacgc tcatcccgta ggcgccgagc gcccccatgg tcttcaggtc
     6241 cgcctggacg ccggcgccgc cggagggatc ggagccggcg acggtcagca ccctggggat
     6301 tgtgctggtc attgtccgct ctcccaggcc ccgcgcagtt gctgcgcggc ctcccgcgga
     6361 tcatccgcca ggcagatggc ggagacgacg gcggccccgg ccagtccccc tgcgcgcaga
     6421 acgggaaggt ccgcgctggt gactccgccg atggcgacgc acggcaggcc agcggacgcg
     6481 gccaggcgga tgacgccacc cgtgccgatg cctgcgggcg cgtccgtctt ggtggcggtg
     6541 gcccgtaccg cccctatgcc aacgtggtcg caggcgccct ccgattccgc cgcggagagt
     6601 tcctccgggg tggctgcgga caggcccagg taggcggctt caccgatgag ctcacgcacc
     6661 acggtcgcag gcaggtcccg ctgccccacg tgcacgcctg ccaccggcgc cccagaccgc
     6721 gggccgccag gaacacgtct acgcggtcgt tgacgatcac cggcacctgc ctaccgacgg
     6781 cgtgagcgac gccgaggacc tgggcgagga agccggcgcc gtcggcgtgc ttggcgcgca
     6841 cctgcacgca ggtgacaccg cccgccacgg cggcacggac ggtgtcggtg accgtgcggc
     6901 cgcgggagcg gcactggtcg gcgtcggtga ccaggtagac ccgcaggtcc ggtgcgggcc
     6961 tcatgagacg gggatcctgg cgaggtcgtc ggcatccaag cagtacagag agtcgagcag
     7021 ggcgacctgg aaggagcccg gacccgcagc agtctcggca gcgatctcgg cggccgcgct
     7081 gtatacggcg tggcaggcaa cggttgcggc gaaggcgtcg gtgccgatgg cgcgcccggc
     7141 cgcaaggaag ccggccgcca gcgcccccag ggcgcagccg ccgccggtca cgcgggtgag
     7201 cagggcggag ccgccaccca cccgggccag gcgtccgtca tcaacgatgg catccacggg
     7261 gccggacacg gcgaccaccg caccggtgcg ggccgagagc gcccgcgcgg ctcctagggc
     7321 ggcggcaaca tcatcggcgg tctccacgcc cctgcctccc gcgccggagc cggcaagggc
     7381 catgatctcc gaggcattgc cgcggatgac ggtcggctcc tcctccagca gccggtgggc
     7441 gagctcggtg cggtgtacca gcgtgcctac cgccacgggg tccagcaccc acggcacgcc
     7501 tgccgcacgc gcggcagcgg cggcctccag ggccgcggcg cgctgctcgg gctgaggcgt
     7561 tcccaagttg atcagcagcg cggaggcgac ggcggcgaag ggcccggcct ccccggtgac
     7621 gtcgaccatc gcgggagcgg ccccggtggc cagtaggaca ttggcggtga aattcgtgac
     7681 cacggagttg gtgatgcagg caaccagtgg gccggcggcg cgcagggact ccagcacttc
     7741 cgcggtaccg gcgggcggcg cgggcgccct caggaccgag ggctcggcgg ggcagtcact
     7801 cgaataagca cttgcggacg cgtgctgcgg catgcgacat cccttcgtca gcattatctg
     7861 gacaggttca acgggtttct ctcagccttg cggcaccccg tgtcgtaggc ataacgatag
     7921 caagcaggcg gccgccccgg aaccgggcgg ttccggggcg gccgggcggt gcgctgagca
     7981 gctggcccgc ggctcagtcg tccaggtagt cgcgcagcac ctgggagcgg ctggggtggc
     8041 gcagcttgct catggtcttg gactctatct ggcggatccg ctcgcgagtc accccgtaga
     8101 ccttgccgat ctcgtccagg gtcttgggct ggccgtcggt caggccgaag cgcatggaca
     8161 ccacgcccgc ctcccgctcg gacagagtgt ccaggacggc gtgcagctgc tcctgcagca
     8221 gggtgaagct gacggcatcg gccggtacga ccgcctcgga gtcctcgatc aggtcaccga
     8281 actcgctgtc tccgtcctcg ccgagcggag tgtgcaggga gatgggctcg cgcccgtact
     8341 tctgcacctc tacgaccttc tccggcgtca tgtccagctc gacggccagc tcctccgggg
     8401 tgggctcgcg gcccaggtcc tgcagcatct gccgctgcac acgggcaagc ttgttgatga
     8461 cctcgaccat gtggacgggg atgcggatgg tgcgcgcctg gtccgccatg gcgcgggtga
     8521 tggcctggcg gatccaccag gtggcgtagg tggagaactt gtagcccttg gtgtagtcga
     8581 acttctccac cgcgcggatc agaccgaggt tgccctcctg gatgaggtcc aggaagagca
     8641 tgccgcggcc ggtgtagcgc ttggccaggg agaccaccag gcgcaggttc gcctccagca
     8701 ggtggttctt ggcgcgctgg ccgtcctgag ccacccagtg cagctcacgg cggtacttgg
     8761 cgtccaggtc gttgccctcg gtggccagca ggtgctcggc gtacaggccg gcctcgatgc
     8821 gcttggccag ctcaacctcc tgcgcggcat tgaggagggc gaccttgccg atctgcttga
     8881 ggtagtcctt gaccgggtcc gcagtggcgc cggcggtgac gaccttctgt gcgggctcgt
     8941 cgccctcgtc tgagtccgat accgtgaagg agccgtcctt gctcttctcg cccttggact
     9001 tcttggtctt cttgcccgcc gccttctcgg cctcttcacg gcgcatgcgc tccagctcac
     9061 cggtcagtgc cgcgattgag gggctcatct tgatgccctt gatgacccag ccgcggaaga
     9121 tgtacccgtt cttggtcagg aactcacgtg cgacaacggg ctcctcctcg ccggggacaa
     9181 tgaaacgcgg cacgggccca tgcccgtagg gggccagggt gatcggctcc tccagggtgc
     9241 cgtcgccgga gatctccagc ccctcaacca cggtgcggct gcgcacgaac agcgtggcgc
     9301 cgggggccag ctgtacgtcc ttcagggctg caggtgtgtt gaaggggcgc cgcttggtcc
     9361 cgtcgccgtt ctcctccagc gagacatcca ggtagtagtc gcgcagctcg ggggcggggg
     9421 cggcgtcgtc cccctgagtg tcgacgtcgt cctcatctac gtcctgtacg tcatccgcgt
     9481 cggcgtagtc gtcctcgtcg tagtcggcct cgtcgtcatc ctcggcgtcg aggtcgtcct
     9541 ctgcgtccag gtcgtcttcc tcgtcgaggt cgacgtcctg gttgccgtca aggacctcgt
     9601 cgacgtcgtc agcgagttcg acgcgctccc gcctggttgt gggagtagga gcaactgtgg
     9661 aagtagccac ggatttcctt tcacgggcgg acggttgagc cggaggggcg cacagagccc
     9721 tgcggaagtc tacgcgagga atccaaacgg ttccgcaggc gtgcgcgccg caccgcggga
     9781 ggctcggaca ggactcggca tccgccaccg gcagaaggga caacgatgca gacggcgcgt
     9841 cttattcccg cggcacgtct ccggcttgcc gccagaggca cccggcagcc cgccgagcgg
     9901 cactcgcgca cggcccgcgc accacacgcc cggctcccgt gcccgccaca agcgcagcac
     9961 cgttccccgc gggccggact caatcatcta gcctgggggc atgaccgacg ttgatgcatt
    10021 gctgccactg gtacgcagcg ccgtcgatgc gcgcctcgag cacgttctgg gcgagctgcg
    10081 cgcccggtgg cacgatcctt ccggtgccgc ggacgaccta ttcgacgccg ccgccaccgc
    10141 ggtgtccggc ggcaagcgca tgcgtgcggt cctgggcgcc gtgggcctgg cgctgctgac
    10201 tcaggacggc gccgcttccg gcgaccgcgg ccggggcggg tgccgtagcg gcaatcgcga
    10261 cgagagccgc cccgagccac ccaggcgtga ggacgtgctc accggctcta ccgccgccta
    10321 tttgggcgcc gcgctggagc tctatcaggc cagcgcactt gttcacgacg atgtgatcga
    10381 cgccgcagac acccgccgtg gtctgccctc cgcacaccgc cggtttgcgg cccgccacct
    10441 tgagaacggt tggcgcggcg cggcggaaaa ctatggcgtg agcgccgcga tcctcctggg
    10501 cgacctgctc atgtcggccg ccgcgtcaga aatgggagcg gcggccgccg cctgtggccc
    10561 ctgcgccggc agagccggcc gggacgcctt cgacgccatg accacggaag tcgccgtggg
    10621 ccagttcctg gacgtgcacc acgaggtact tcccctgcct gcccccaccg cgcaaccggt
    10681 gcaggcgggt gccgccatgc accgggccgc gctcgcggtt gtgcggcaca agtccgcgcg
    10741 ctattcagtg atgtacccgc tgctagtcgg ggcgctgctg gccggcgtgg atccgcacag
    10801 tgagctgttc agggtgctgg aggtgttcgg ggaggagatc ggaatcgcct tccaactgcg
    10861 tgacgacgtc ctcggcgtct tcggcgatcc gtccctcacc ggtaagccgg cgggcgatga
    10921 cctgcgcgag ggcaagcgca cagtactgct ggccctgacc tggcagcggt gcagtgacgc
    10981 cgaccgcgcc ctgctgaccc gggtgctgtc acggggccat gccgccgcgg atgaggacat
    11041 cgcagcggcc actgaggtta tccgtgactg cggcgccctg acggcgcacg aggaggagat
    11101 cgcgagccac accgccgccg gcctgggcgc cctggcggct tcgcccgcca cactgaatga
    11161 cgtcgcgcgg cagtcactga ccgccctggc ggaggttctg acctcccgcc gcagctagcg
    11221 cccaatccgc gtcccaagcg gttccagtgt cttattgagc acgtaccgcc gagcggcgta
    11281 atgcaccggg tgcccgtgag gcccgtacac tcggccccgt gagcaaggat cctctcatcg
    11341 gccgtctggt cgacgctcgt tatgagatcg tcgaccgggt ggcccgtggg ggcatggcca
    11401 ccgtctaccg ggcgcaggac cgccgcctgg atcgtctggt agcgctgaag ctcatgcacc
    11461 cgcacctggc cgactccccc gacttcgtgg cccggttccg gcgcgaggcc agagcggcag
    11521 cccgactgtc caaccccggg gtggtggcgg tatacgacca gggcagccta gacggcgtcg
    11581 cctacctggt gatggagctc gtggagggcc ccaatctgcg tgacctcatc gcggcaggtc
    11641 ccctgactgt aagggaggcg ctcgggctga cggcccaggt gctccggccc ctgggggccg
    11701 ctcaccgcgc cggcttggtg caccgggacg tcaagccgga gaacgtgctg ctgcccgccg
    11761 acgggtcggt agccaaggtc gccgacttcg gccttgctcg cgccgtcacg gaggtcaccc
    11821 agaccaccac cgggaacgtc ctgggcacgg tcgcctacct cgcgccggag ctgattacca
    11881 ccggttcctc agccccttgc gcagacgtct tctccgtggg cgtgatcctg tacgagctac
    11941 tcaccggcgc ccagcccttc actgcggaga ctcccatcca gatcgccttc cgcaacgttc
    12001 atgaggacgt gcccgcgccg tcggagcgcc tgcccgacct ggcgcagagc gttgacgccc
    12061 tggtagcaca gatgacccgc cgggcgccag aggagcggct ggccgacgcc gacgcggcac
    12121 tgagccgact gcggcaggtc gtctccgccc tgtccgacgc ggagctggcg gtcaaacgcg
    12181 gtggggccac cggttcggtg cgtacccagg aggtgctggc ggccaatgcc gaggccgccc
    12241 acaccgcgat gctggcggcc gacggcgacg cgagcgagcc tgacgacgcc caggtccccg
    12301 cggacgcggc caccccgggc gccggcctgc gcacggtgtc cctgcccatc ggctccatag
    12361 ccccggacga ggactccgag tcccgcgacg gcaccacccg tgcgctggac cgccgccagg
    12421 cggtgcgggc cgggtcgcag gaggagaccg cgagggtagc ccggcattcc gcacgccgcc
    12481 cgcgtcggcg cgcactggtt gccgccgggt tggtgctgct gaccgccgga ggcgcaggcg
    12541 cctggtactt cggtgccggt ccggggcgta cggtcccggt gccgcagatc gccgggatga
    12601 ccgctgctga ggcgcaggcg ctagtcgagt cggcgggact ggtctggggc gcccccactc
    12661 gcgcctattc cgacacagtg cccgcggact cggtgatctc ctcctccccc gaggccgcga
    12721 cccgcatgca ccccggagag gcagtcaccc cggtgatttc ccgtggcatt gagcagaaga
    12781 ccgttcccga cgtcgtcggt tccagccagg acgacgccac caccgcgatc acggacgcag
    12841 ggctgtcgct cggcgccgtc accaagacct attcagactc ggtcgcatcc ggcatggtca
    12901 tctcctccga accggttgcg ggcacaaccg tgaaccactc ctcggcggtc gcgatcgtgg
    12961 tgtcgctggg acgccagccc gccgtcgtcc cggatgtcac cggcatgagc gttgacgacg
    13021 ccaccactac gctgcaagcg gccgggctca cgctcggtac gcagtcggag gcgttctccg
    13081 acgacgtcgc ctcagggctg gtcatttcct ccagccctgc atccggcgcg gagggctact
    13141 accacggtga cgcggtggac gtgacggtat ccaagggccc ggagatggtg aacgtgccgg
    13201 acgtcgccgg catgagcgag caggaggcca cggcggcgct ccaggaagtc ggcctggagg
    13261 tggaggtgtc ccgggtcctg ggtggcctgt tcggcacggc gcactccacc gatccggctg
    13321 cgggtgaaag cgtgcggaag ggctcgaaag taaccttgaa cgtggtctga tcggcgctga
    13381 gccggagcgg cggctctgag cccccgcctg gcacaaccga ggcgaccgcc tggcacaacc
    13441 gggcgacggc gcccacgggc ctgccgcccc tgagcgccgt cgttttagcg gttggcgtca
    13501 gccgcgcagc atctccgcaa cctcgaaggc catctccagt gactgctggt ggttcagccg
    13561 cggatccacg agggtctcgt aacggcgcgc cagcccggcc tcgtcgatgt gctccccacc
    13621 gccgaggacc tcggtgacat cgtccccggt gagctccacg tgaatgcccg cgggcacggt
    13681 acccagggcc cggtgcacct cgaagaagcc acggacctca tccatgatcg tgtcgaagcg
    13741 acgggtcttg tagccgtttt ccgaggtgat ggtgttgccg tgcatggggt cggtgatcca
    13801 ggtgaccggt cggccatcgg cgcggacgat ctccaccagc tccggcagta catcccggat
    13861 gcggtcagca cccatgcgcg tgatcaggct gagccgaccg gggtcgcctt cagggttgag
    13921 gtggtcgatc agggacagca gctcctcgcg ggtggtcgtc gggccgattt tcacacccac
    13981 cgggttgtgc acgcccgcca gcagggccac atgggcgtcg tcggcgccac gggtgcgctc
    14041 ccccacccac aggaagtggg cggaggtgtc gtaaaggcgt ccgctgcggg agtcctcacg
    14101 cgtcatggcg tcctcgtact ccagcaggag ggcctcgtgg gcggcgtaga agtcgacctg
    14161 gcgcaaggcc tcgaagtcca cgccggcggc ctccatgaag cgcatcgccc ggtcgatctc
    14221 cccggcgaag gactcaaagc gcttgtaggc gggattcgcg gtgaaacccc ggttccagga
    14281 gtggacctcc cgcaggtccg cgtagcctcc catggtgaag gagcgaatta ggttcagggt
    14341 ggtgccggcg cgcaggtagg cgtcaaccat ccgctgcggg ttggggatgc gggcctcggc
    14401 ggtaaaggcg tggtcattga ccgagtcacc gcggtaggag ggcagagtga cgccgttacg
    14461 ggtctcggtg tccgagctgc gcggcttggc gtactggccc gccatgcgcc cgatcttgac
    14521 caccggggtg gaggctccgt aggtgagcac cgcggccatt tgcaggatgg tctgcagctt
    14581 caggcggatg ttgatggcgg tgttgtcatg gaatgactcg gcgcagtctc cccccatgag
    14641 cacgaatgcc cggccctgcg atgccgatac catcttctcg cgcagcgagt ccacctcacc
    14701 ggcgaatacc agcgggggcc gggtgcgcag gtccgccgca gcgtcggcga gcgcctgcgg
    14761 gtccgggtaa tggggctgct gggcggcgtg gtgctgacgc cagccggctg cctcgccggg
    14821 aacctggagc tcgttcatca tggcgccagc ataggcgagc gccgcgtctg gctgggcgtc
    14881 tcgccacaag gtgggatata aggcacgtcc tcggtcccgc ccgggcccgc tccgtgacgg
    14941 cgcgaaagtg ccggttcaaa acggttcgac cggctggttg gaggtgggac cgggccggtc
    15001 ggccacggcg atccgtgtcc gaccggcccg tccataggta gcccacgcct ggcggcgggg
    15061 gcggcggctc acgcctcgcc gtcggcgggg gcggcgggct cgagcgcctg gccgagctcg
    15121 gccatcaggt ccacgaacca ctgctgcgtg atgtcgaagg gcttgccgcc ggcgatgcgg
    15181 tcgaaggcga tggcaccgag ctggtcgccg ttctcctcgt cctggccgat gacgccgggc
    15241 tcgccccgca gggcgcagtc gacggcaagg tcacacatct gcttgatcag ggccaggtcc
    15301 tcctcgttgg cggcggaggc gcgcgagtag tagccggact tctgcaccat taccttctcg
    15361 gcaccgatct tctcggcgaa ctggcgggcg aaccactggc cggggttaat ggtgtcgagc
    15421 ttgacgtggc cgaaggggtc gcgctggacc tcctcgcccc tggcctccat ctccgcgatg
    15481 atctcgggaa cgccggcgcc ctcggacagg aagatgttca cgttgccctg ctcgtccatg
    15541 atggccttga ggcgctcggc ctcggcggca atgtccagct tggcctccgg cacgaacacg
    15601 gcgtgcacgt cccagcgctc ctgggtcagt cccagggagg gcgcccactg acggtccttg
    15661 agcagctcgt ggtagcggcg ggccgtctcg gcggtgaggt agccgcagtt gcggcccatg
    15721 cactcgtgca cgatcagcat gcgcgggttg gagcggtgct cgccgatcac gttgagggcg
    15781 aagccggcgc cctgctcggc cgcggtccag gcgcccagcg actggcggat cgggacgacg
    15841 tcattgtcga tggtcttggg caggccgacg acggtgaggt cgtagtcgtg ctcgtgcagg
    15901 tatgcggcca ggtccgcggc ggtggtgttg gtgtcgtcgc cgccaatggt gtgcagcacg
    15961 tcgacgccgt cctcacgcag ccgctcggcg gcgaaggcga gcgggtccac gccctccttg
    16021 accaggccgc gctcgacgag gttcttggcg ttggtgagct tcacgcggga gttgccgatc
    16081 ggggagccgc cgtactggcg cagcacgccg gcgttcttgc ggccctcgtc gtcgatgacg
    16141 acgtagttac cggtgagcag gccgtggtat ccgtactggt aggcgatgat ctcgacgtcg
    16201 ggggcgacct cggtgtagcg ctcgatgagg tcgccgacgg cggcggacag acagggggcg
    16261 aagccgcccg cggtgaggag ggcgacgcga cggatcgaca tcggaaacct ttcgtcggtg
    16321 gtggggctta tcgcggccat actaccggga cgccgccgct gtgcggccag atgcctcacc
    16381 ccaacctcac ccctcgccga gaccggcact cgtcgcgcac tgagaccggc accagtgacg
    16441 cgccgagagg catcgatgca ggccgggctg cagcatggcg gacacactcg gcgatcacac
    16501 atgcgttatc atgggtgggt gacacagcgc accgaacgtg agtggatccg tttccgtcgg
    16561 cacgcggcgg ggctgagcca acgtgaactc gcggatcgca ccggtgtcag ccaaccactc
    16621 attgcagcca ttgagtccgg cgcgcgtcgc gcatcccgga gcacgctgca gcggctgaca
    16681 caggcattgc aggtgcgtcc ttcagatctc ctgcacgctg cacgccagga cgtcatcgag
    16741 ttggccgctg cacatggatg ccaagtcatc ggagtcttcg gctccgttgc cagcggcacg
    16801 gatcgccagg actctgacat cgatctgata gtccgtttcc ctgaacacgc ggacatcctc
    16861 gacctgttgg agcttgagga agagctgtcg gatctactga cggtgcccgt cgacgtgatc
    16921 tcggccagca gcggctcagt cgcgatgtcc gggacttccc tagaaccggt acggatatga
    16981 gcactacatc accgtccgcg gaccgaacag aacgacgact cgcggatctg agacgtttcg
    17041 gagacgaggc cgccttcatc gtcagccacg gcttcgacgc atacgcagca gactcgatgg
    17101 aaggagcgct gctgcgtaat gccggtgaac gggtgctaat caaggttgcc accgtcgtcg
    17161 agaaactacc ccgggagtac aaggaacagt tccccgacgt cgactgggtc gggatcatgc
    17221 gcatgcgcaa cctggtcgcg caccactacg acaaggtcaa cgacgacctg atgttccgtg
    17281 cactcgaagt ccgcatcccc ggtctgctaa ccgcgctcgg actgtaattg ggctcggtgt
    17341 actactgtcc ggattcggca tgaacggcgt cgaccgacca agaactaccc aaagataccg
    17401 catgtttcca acgttcctga aaacacagac cggcgcgtca gccccgttcg tgccgatctt
    17461 ggacattctg cgcgctacgc gggactcgaa ggccgatgca cacggggggg gcgacaccga
    17521 cgcgccgtcg tcgccccgtc aacggtagcc gtcgctgcga tggtcaacgg taaccaccac
    17581 aacccggcgt gcgtcatcat caattctgta gatgatgcgg tagtcgcccc gtcgggcact
    17641 gtggagcccg gccagctcaa agcgcaaagg ctttccgacg cgatacggat tgtctcgcaa
    17701 tggtccgtaa agaaactcga cgactgcggt gacgaccttc tccggatgcg agcgcaggtc
    17761 gcgcttagca cgtgccgcaa gtgcgatcgc gtagggcacg gactcacccc ttcggggagt
    17821 cgagcaactc gtccttgctg agcacctcca cccgctgagc acccaaatca tccactcctg
    17881 cacggatccg ctcgattagc gcggggcggc tgaggatgcc gagcgtctcc tcgagtgact
    17941 ccaggtcatc tgcagagatg acgactgccg cggggcgccc gtgccgggtg atcgttacgc
    18001 ggctgtgctc ccgctccacc tggccgacga cctcggaaag gtggttcttc acatcgcgca
    18061 acggcatgac agcgtcgacc gacatggcaa caattgtagg cgtacacgac tcatgcgccg
    18121 catggacgct tgacgaagtt atacatacag gcttgtctgt aagcatgcgt cgcaccgccg
    18181 ccgaggccgc cgagacccgc caagccatca tccgctccgc cttgcaccgc ttcgcgaagg
    18241 acggttggga ggcctgctcg ctggtggagg tggcccgcgg cgccgacgta actcgaggcg
    18301 ccgtctacca ccacttcacc ggcaagcggg agttgctgga cgccgccctc tccgagcaat
    18361 ggcacagcca gggtgaggca cttctcgcgg cgctcgacgc ctccacggca ccagaggtgc
    18421 ggctaacggc attcctggcg gactacctgc gcaggcttcg cggggacaca gccttccgcg
    18481 aactcgccgt cgtcaccgtt ctcgtagcgc cgcaggcacc ggcggtcaag tccggactgg
    18541 agcagaagac ggcggccctc gcgcagtggt cggcgctgct catcggggtc ctgaccgagt
    18601 gcgaggagcg gctgcgcgct ccgctcgaca tcgcccgttt caacatcgcg tcattcctgt
    18661 acggcgccac gcttaccgcg gcgctcacgc cggaggacct ccccgcatca gggtgctgcg
    18721 aggcgacggc gcgtgccctc gtcgcgggcc tgatcaccgt cgaatcgccc tgacaccgaa
    18781 gaatgacacc gaagaaggag tgggcatgca tccatcgtcc accgaagccg ccaccaatcc
    18841 gcacgtggcc gtaacagtgg cctgcgtcgc cctgttcacc gacatgctcg tctacgggat
    18901 tctcatcccg gtgctccctc tgcttcccgc cgtggccgag gccggcgcct cggcaaccgg
    18961 tctgctcttc gccgcctatg ccgccgcact ggtgatagtc actccactcg ctggtcgagt
    19021 cgtggacagg cacggccccg cggaccgctg ctagttgctg tggtgggcct ggcgtgcgcg
    19081 tgtctgctgt tcaccatcgg tggtccctac tggttgcttc taacggcccg cacgctccag
    19141 ggagccgccg ccggattgag ctgggtggcc ggactgtccc tgatcgccgg gaccgtacct
    19201 ctgcggcaac gcgggaccta tctcggactg gcgatgagca tggtttcggt tggcgtgttg
    19261 gcgggacctc ccctggcggg ctggttggct aggttcggag ggcattcggc acccttcctc
    19321 tgtgcgatcg tgcttctggc gatcgacggc gggctgcgag tcgccttcgt ccgtccgacc
    19381 ccgccgcccg acgacgatcc cgccaccgcg atggacgtgt tgcgaacacc aggatgtcgg
    19441 ccagtagttg cgctgattct cttcggtgcc gccgccgcgg ctgtgggcct ggttctggtg
    19501 ggaatcggcc cgaactaccc ggtaatcatc gccggactca tgtgtctggg tgtcgcaatt
    19561 gccctcctgg tcgtaccggc aggtgcacta ataggcgttc agggagccat agccacaccg
    19621 ccgactatcg gcggcgccta ctccctctac aacctggctt acgcgggcgg cctggtcctg
    19681 gggcccgccg ccacgatact cgcccggttg ccaagcaggt tcgcggtcat gcccgggtga
    19741 aactgtccgg attcggcatg aacggcgtcg ggcgaccaag aaccacccga agaaaccgca
    19801 tgattccaac gttcctgaaa acgcagaccg gcgcgccagc tccgttcgtg ccgatctcgg
    19861 acatttcggt ccccggactg tcagactgtc agtggtcgtc ggaacgcgac tcggcatccg
    19921 gcgctacgcc ctcgtcaccc tcaggcgccc cctcgatgtc ctccacctct tcctcttctt
    19981 ccgcttcatc cggctccgcc ggcggctcgg ggacctcgac gtcgggagcg gggcggccgc
    20041 cgggggcctc gacgggcgcg gcggccggcc gcttggcggc cagctcttca agcatctcgt
    20101 ctacgacctc cgcggccgtc ttcttctccg cgtccatcgc cttctttacg tccgcggcgt
    20161 acaggtccac gtattcctgg ccggacaggg acatcagtgc gtacatgatc tcgtcggtga
    20221 tggagcgcag cacgaagcgg tcgttctcca ggccctggta gcgggagaag tccagcggct
    20281 cgccaacgac gatgcccacg cggtgccggg tggagggaac cacctggccg atcggctgag
    20341 ccaggttgga gccgatcatg gccacgggga tcaccggcgc cccggtggcc agggcgacgc
    20401 gcgccacccc ggtcttgccc cggtacaggc gcccatcagg gctgcgggtg ccctcggggt
    20461 agatgccgaa cagctcgccc gagcgcagtc ggtcgatccc ggcctgcagg gccgccatgg
    20521 acgctttgcc cccggagcgg tccacgggaa tggtgccgac ggcggtcatg aagttcttca
    20581 cggcccagcc cttgatgccc ttgccggtga agtagtcgga cttgccgatg aaggcgacct
    20641 cgcggtccat cagcagcggc aggaagaagg aatcgataac cgccaggtgg ttggaggcca
    20701 ggatggcggg gccctcggcg gggatgttct cctcaccgcg gatccacggc tggtacagca
    20761 tctccatggc cgggccgacg gcggccttga tacctcggta ccccatgtgg gacctcctgt
    20821 gctgcggcgg gcgggaagtc gccgggccgt ccgggttacg cccgccgggc gtgtccgcgg
    20881 ctggatcggc tgctcacaaa gtctagcctc gcgctgtgcc cttcgatgcg ctctcgcccc
    20941 aaccgtccca cgccacaggc gccgtacggc ttccgggcgt ctggcgggcg gaggatgaaa
    21001 cccgcccggt acaggcgtct ttcgcggata tgggcaccgc gctgcgcgat gtcaccttcg
    21061 tagtcgtcga tctggagacc accgggggcg ggccgggcgc gcacgccatc accgagatcg
    21121 gcgctgtaag ggttcgcggc ggcgcggtcg attcggaatt ctccacgctc gtaaatccgg
    21181 gcgccgccat tcccgcccag atcaccgtcc tgaccggt
//
