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Overview
1.1
1.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP025249.1 (Actinomyces sp. 432)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | lanthipeptide-class-ii | 76,767 | 104,579 |
Region 2 | terpene-precursor | 1,640,641 | 1,661,858 |  |

NZ_CP025249.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
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Location: 76,767 - 104,579 nt. (total: 27,813 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
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Gene details
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Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
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Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
CWT12_RS00395: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

CWT12_RS00405: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.64 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.60 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5 |  | 0.55 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000528.5 |  | 0.53 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000552.3 |  | 0.53 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.4 |  | 0.51 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0001391.3 |  | 0.51 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.64 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.60 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5 |  | 0.55 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000528.5 |  | 0.53 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000552.3 |  | 0.53 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.4 |  | 0.51 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0001391.3 |  | 0.51 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for CWT12_RS00395

CWT12_RS00385
Leader:
MDAKFTSTPAAKSDLLDEITEQDYVTANGG
Core:
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
Core with dehydrations:
F F P W L Dha R K L G N Dhb G Y V Cys Dhb L Dhb K E Cys Q R M Cys N

#### antiSMASH-DB 4.0 matches for CWT12_RS00385

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
1
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
27
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
1
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
27
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C
26
L S+ L G N G Y V C T L T K E C Q++C
6
L S K S L G N K G Y V C T L T K E C Q K L C
27
59.3%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S+ L G N G +C T L T K E C Q M C N
4
V S K N L G N K G R I C T L T K E C Q S M C N
26
with 108 more sequence matches
Only the first 10 are displayed here.
56.7%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S L G N G C T L T K E C Q R C N
8
L S N Y L G N N G G W C T L T K E C Q R S C N
30
56.7%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S L G N G C T L T K E C Q R C N
8
L S D Y L G N K G G W C T L T K E C Q R S C N
30
55.6%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide
Lanthipeptides: HBA49_RS00770_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S R L G N G C T+T K E C C N
1
L S R L L G N N G R W C T I T K E C M P S C N
23
55.2%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S L G N T G C T L T K E C Q C N
6
I S C H L G N T G Q F C T L T K E C Q P S C N
28
55.2%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S L G N T G C T L T K E C Q C N
6
I S C H L G N T G R F C T L T K E C Q P N C N
28
53.6%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C
26
+S +L G N G C T L T K E C Q R C
6
I S C Q L G N K G Q W C T L T K E C Q R S C
27
53.6%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S K L G N G C T L T E C Q C N
6
I S C K L G N K G A W C T L T V E C Q S S C N
28
53.6%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
1
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
27
++ +S L G N G C T L T K E C Q C N
2
W Y S E M S A A L G N R G S Y C T L T K E C Q A C C N
28
53.6%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
1
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
27
++ L S L G N G C T+T K E C Q C N
2
W Y A D L S A S L G N R G S Y C T I T K E C Q A C C N
28
53.3%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S L G N G C T L T K E C Q C N
8
L S D F L G N Q G G W C T L T K E C Q P N C N
30

#### MIBiG 4.0 matches for CWT12_RS00385

53.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S L G N G C T L T K E C Q C N
8
L S N A L G N N G G W C T L T K E C Q P N C N
30
46.4%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S +L G N G C T L T E C C N
6
I S C R L G N K G A Y C T L T V E C M P S C N
28
23.1%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
16
C T L T K E C Q R M C N
27
C T L+K E C Q C N
28
C T L S K E C Q P N C N
39
CWT12_RS00390
Leader:
MTHENLTGTYTASELEELNDISAYG
Core:
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
Core with dehydrations:
G Dhb Dhb P Dha Dha W P Cys G I G I Dhb Dhb Dhb V Cys P Dhb A A Cys Dha Dha K Cys R

#### antiSMASH-DB 4.0 matches for CWT12_RS00390

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide
Lanthipeptides: CWT12_RS00390_lanthipeptide
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
28
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
28
89.3%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
28
G T T P S S W P C G I G I T T T+C P T A C+S K C R
1
G T T P S S W P C G I G I T T T I C P T A V C T S K C R
28
46.9%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide
Lanthipeptides: BALI_RS00915_lanthipeptide
2
T T P S S W P C G I G I T T T V C P T A A C S S K C
27
T T P S S P C G +T C P+ A C+S C
7
T T P S S L P C G T L V T A V W C P S N A C T S D C
32
with 90 more sequence matches
Only the first 10 are displayed here.
46.4%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
3
T P S S W P C G I G I T T T V C P T A A C S S K C
27
T S S W C G+ + C P+ A C+S K C
5
T T S S W I C G V A-S A A F C P S T A C T S K C
28
43.8%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
2
T T P S S W P C G I G I T T T V C P T A A C S S K C
27
T T P S S P C G+ +T C P+ C+S C
7
T T P S S L P C G V F V T A A F C P S T K C T S S C
32
43.8%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
2
T T P S S W P C G I G I T T T V C P T A A C S S K C
27
T T P S S C G I ++ C P T C+S+C
7
T T P S S V A C G I A V S A L F C P T T K C T S Q C
32
42.9%
NZ_BIFH01000022.1 and 1 other:
NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS52585_lanthipeptide
Lanthipeptides: EMA17_RS52585_lanthipeptide
13
I T T T V C P T A A C S S K C
27
I T T+C P T A C S S K C
14
I T A T M C P T T A C S S K C
28
42.9%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS18310_lanthipeptide
5
S S W P C G I G I T T T V----C P T A A C S S K C
27
++ P C +G I T T+ C P T C+S+C
2
T T L P C-V G I T V T I S V S M C P T T K C T S Q C
27
41.9%
NZ_CP030280.1 and 3 others:
NZ_CP030280.1 Lanthipeptides: DQQ01_RS15860_lanthipeptide NZ_CP030280.1 Lanthipeptides: DQQ01_RS15865_lanthipeptide NZ_CP030280.1 Lanthipeptides: DQQ01_RS15860_lanthipeptide
Lanthipeptides: DQQ01_RS15865_lanthipeptide
6
S W P C G I G I T T T V C P T A A C S S K C
27
S+ G I T V P T A C S S K C
11
S F I T G I-F T G M V A P T G A C S S K C
31
41.9%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide
Lanthipeptides: C8268_RS00150_lanthipeptide
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C
27
G T S S W C G +T +C P+ A C+ C
6
G I T T S S W I C G F-V T A A L C P S T A C T G D C
31
41.0%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
3
T P S S W P C G I G---I T T T V C P T A A C S S K C
27
T S S W P C I G I+ +C P T C+S K C
12
T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
40.0%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS21935_lanthipeptide
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C
27
G P + P I +T C P+ C S S K C
4
G G V P I T V P I T I A A S T A F C P S I K C S S K C
30
39.5%
NZ_JAHXMW010000012.1 and 3 others:
NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide
Lanthipeptides: KZX51_RS23840_lanthipeptide
5
S S W P C G I-------G I T T T V--C P T A A C S S K C
27
S S W P C I I T + C P+ A C S S+C
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38

#### MIBiG 4.0 matches for CWT12_RS00390

25.0%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
17
V C P T A A C S S K C
27
C P T C+S K C
16
F C P T T K C T S K C
26
18.9%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
11
I G I T T T V C P T A A C S S K C
27
+G++ C P T C+S+C
21
V G V S A A F C P T T K C T S R C
37
14.3%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
13
I T T T V C P T A A C S
24
+ T V C +C+
11
L L N T V C I G I S C A
22
allorf_0077306_0077500
Leader:
MLVTSGIPLPSGAKPIGRLGGSIGG
Core:
E R A F G G K V G A E N S G G V C P E P F R A H A A A V I R S G H P Q P H F R
Core with dehydrations:
E R A F G G K V G A E N Dha G G V Cys P E P F R A H A A A V I R Dha G H P Q P H F R

#### antiSMASH-DB 4.0 matches for allorf_0077306_0077500

100.0%
NZ_CP025249.1:
Lanthipeptides: allorf_0077306_0077500_lanthipeptide
1
E R A F G G K V G A E N S G G V C P E P F R A H A A A V I R S G H P Q P H F R
39
E R A F G G K V G A E N S G G V C P E P F R A H A A A V I R S G H P Q P H F R
1
E R A F G G K V G A E N S G G V C P E P F R A H A A A V I R S G H P Q P H F R
39
23.1%
NZ_JAASAG010000001.1:
Lanthipeptides: allorf_346027_346167_lanthipeptide
1
E R A F G G K V G A E N
12
E R A F G G K+ A N
8
E R A F G G K L S A R N
19
17.4%
NZ_CP097263.1:
Lanthipeptides: M3Q35_RS22090_lanthipeptide
7
K V G A E N S G G V C P E P F R A H A A A V I R S G H P Q
35
++ E G+ P R+ S H P Q
14
E I A C E T D S G L G C G P V R S Q D I C P T E S C H P Q
42
with 2 more sequence matches
15.6%
NZ_CP115450.1:
Lanthipeptides: allorf_7929783_7929983_lanthipeptide
21
F R A H A A A V I R S G H P Q P
36
F A V+R G P P
13
F Y A R T D T V V R G G T P W P
28
11.5%
NZ_JAGGRJ010000031.1:
Lanthipeptides: allorf_016625_016834_lanthipeptide
13
S G G V C P E P F R A H A A A
27
+ G C P+P R A+A
35
A S G E C P K P V R T T A S A
49

#### MIBiG 4.0 matches for allorf_0077306_0077500

12.8%
BGC0000580.3 (EGD17354.1):
Lasso peptide: xanthomonin II or xanthomonin I
5
G G K V G A E N S G G
15
G G + E G G
1
G G P L A G E E I G G
11
12.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
5
G G K V G A E N S G G V C
17
G G + E G G+
1
G G P L A G E E M G G I T
13
10.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
12
N S G G V C P
18
N+G G C
14
N N G G W C T
20
allorf_0084004_0084123
Leader:
MSLPGGPWDTAERRVEVGR
Core:
E S C R E V G I R E P V W W C R G G V G
Core with dehydrations:
E Dha Cys R E V G I R E P V W W Cys R G G V G

#### antiSMASH-DB 4.0 matches for allorf_0084004_0084123

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: allorf_0084004_0084123_lanthipeptide
Lanthipeptides: allorf_0084004_0084123_lanthipeptide
1
E S C R E V G I R E P V W W C R G G V G
20
E S C R E V G I R E P V W W C R G G V G
1
E S C R E V G I R E P V W W C R G G V G
20
25.0%
NZ_JAINUL010000001.1:
Lanthipeptides: allorf_8079390_8079587_lanthipeptide
6
V G I R E P V W W C R G G V
19
+G +W+C+ G V
3
I G Q S S T I W Y C K T G V
16
allorf_0097382_0097492
Leader:
MRETLGRWIGRARPPGA
Core:
G K G T A C V M S C S R H W C S I G R
Core with dehydrations:
G K G Dhb A Cys V M Dha Cys Dha R H W Cys Dha I G R

#### antiSMASH-DB 4.0 matches for allorf_0097382_0097492

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: allorf_0097382_0097492_lanthipeptide
Lanthipeptides: allorf_0097382_0097492_lanthipeptide
1
G K G T A C V M S C S R H W C S I G R
19
G K G T A C V M S C S R H W C S I G R
1
G K G T A C V M S C S R H W C S I G R
19
29.2%
NZ_KZ559472.1:
Lanthipeptides: CXR44_RS39555_lanthipeptide
5
A C V M S C S R H W C S
16
A C V +C R C S
4
A C V N T C K R T V C S
15
12.2%
NZ_CP032544.1 and 2 others:
NZ_CP050861.1 Lanthipeptides: HER15_RS06230_lanthipeptide NZ_LDOD01000011.1 Lanthipeptides: ACI36_RS12155_lanthipeptide
Lanthipeptides: D6200_RS07485_lanthipeptide
5
A C V M S C S R H W C
15
+C+ S C+R+ C
25
S C I K S C N R N S C
35
with 1 more sequence matches
6.9%
NZ_CP017169.1:
Lanthipeptides: allorf_8034042_8034278_lanthipeptide
10
C S R H W
14
C+R H W
17
C T R H W
21

#### MIBiG 4.0 matches for allorf_0097382_0097492

10.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
G K G T A C V M S
9
K G C ++
12
N K G A Y C T L T
20
allorf_0098372_0098596
Leader:
MIEQSHFG
Core:
P G S E V G E M S I G D A L R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
Core with dehydrations:
P G Dha E V G E M Dha I G D A L R E M V D W A G R V G Dha A G V A Dhb E G L A Dha P R Dha D Dhb D M A M A E R V R R E H M Cys G D F L Dha V V D P V G

#### antiSMASH-DB 4.0 matches for allorf_0098372_0098596

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: allorf_0098372_0098596_lanthipeptide
Lanthipeptides: allorf_0098372_0098596_lanthipeptide
1
P G S E V G E M S I G D A L R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
66
P G S E V G E M S I G D A L R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
1
P G S E V G E M S I G D A L R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
66
45.5%
NZ_CP039292.1:
Lanthipeptides: allorf_0094578_0094799_lanthipeptide
30
A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
66
A G+ S P R S D T D M A M A E R V R R E M C D F L+V V D P V G
1
A A A G V V S P R S D T D M A M A E R V R R E R M C E D F L T V V D P V G
37
22.7%
NZ_CP022098.1:
Lanthipeptides: allorf_01481640_01481861_lanthipeptide
15
R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P
64
++ + W G G S G V R D+ A+ E H C G F+ ++ P
8
K Q W M S W W G-A G S G G V H F------R Q G M D L E C A D----E H R C G C F V G M L W P
46
with 3 more sequence matches
13.6%
NZ_LT607733.1:
Lanthipeptides: allorf_2263047_2263265_lanthipeptide
8
M S I G D A L R E M V D W A G R V G S A G V A T E G
33
++I G D L D G++G+A G
12
V T I G D Q L N G Q R D I G G K L G A A H A C G R G
37
10.6%
NZ_LBJF01000016.1:
Lassopeptides: XH87_RS09510_lassopeptide
50
R R E H M C G D F L S V V D
63
R E H G D+ V D
7
R A E H T T G D Y Y Y V D D
20
7.6%
NZ_CP113837.1:
Lanthipeptides: allorf_4171641_4171739_lanthipeptide
51
R E H M C G D F
58
R+H+C D F
1
R D H I C K D F
8
allorf_0098430_0098639
Leader:
MRLERWWIGQEELARQAWRRKDSPAPGA
Core:
I Q T W R W Q R G C E G N T C A V T S Y R L W I R W D S R I L S Y T A V W P A H H
Core with dehydrations:
I Q Dhb W R W Q R G Cys E G N Dhb Cys A V Dhb Dha Y R L W I R W D Dha R I L Dha Y Dhb A V W P A H H

#### antiSMASH-DB 4.0 matches for allorf_0098430_0098639

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: allorf_0098430_0098639_lanthipeptide
Lanthipeptides: allorf_0098430_0098639_lanthipeptide
1
I Q T W R W Q R G C E G N T C A V T S Y R L W I R W D S R I L S Y T A V W P A H H
41
I Q T W R W Q R G C E G N T C A V T S Y R L W I R W D S R I L S Y T A V W P A H H
1
I Q T W R W Q R G C E G N T C A V T S Y R L W I R W D S R I L S Y T A V W P A H H
41
39.0%
NZ_CP039292.1:
Lanthipeptides: allorf_0094630_0094776_lanthipeptide
1
I Q T W R W Q R G C E G N T C A V T S
19
I+T W R W Q R G C E G N C A T S
1
I R T W R W Q R G C E G N A C A R T S
19
14.6%
NZ_LT629701.1:
Lanthipeptides: allorf_4965071_4965214_lanthipeptide
8
R G C E G N T
14
R G C E G+T
20
R G C E G S T
26

#### MIBiG 4.0 matches for allorf_0098430_0098639

9.8%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
10
C E G N T C A
16
C G +C A
16
C I G I S C A
22

#### Lanthipeptide(s) for CWT12_RS00405

CWT12_RS00385
Leader:
MDAKFTSTPAAKSDLLDEITEQDYVTANGG
Core:
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
Core with dehydrations:
F F P W L Dha R K L G N Dhb G Y V Cys Dhb L Dhb K E Cys Q R M Cys N

#### antiSMASH-DB 4.0 matches for CWT12_RS00385

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
1
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
27
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
1
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
27
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C
26
L S+ L G N G Y V C T L T K E C Q++C
6
L S K S L G N K G Y V C T L T K E C Q K L C
27
59.3%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S+ L G N G +C T L T K E C Q M C N
4
V S K N L G N K G R I C T L T K E C Q S M C N
26
with 108 more sequence matches
Only the first 10 are displayed here.
56.7%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S L G N G C T L T K E C Q R C N
8
L S N Y L G N N G G W C T L T K E C Q R S C N
30
56.7%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S L G N G C T L T K E C Q R C N
8
L S D Y L G N K G G W C T L T K E C Q R S C N
30
55.6%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide
Lanthipeptides: HBA49_RS00770_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S R L G N G C T+T K E C C N
1
L S R L L G N N G R W C T I T K E C M P S C N
23
55.2%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S L G N T G C T L T K E C Q C N
6
I S C H L G N T G Q F C T L T K E C Q P S C N
28
55.2%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S L G N T G C T L T K E C Q C N
6
I S C H L G N T G R F C T L T K E C Q P N C N
28
53.6%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C
26
+S +L G N G C T L T K E C Q R C
6
I S C Q L G N K G Q W C T L T K E C Q R S C
27
53.6%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S K L G N G C T L T E C Q C N
6
I S C K L G N K G A W C T L T V E C Q S S C N
28
53.6%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
1
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
27
++ +S L G N G C T L T K E C Q C N
2
W Y S E M S A A L G N R G S Y C T L T K E C Q A C C N
28
53.6%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
1
F F P W L S R K L G N T G Y V C T L T K E C Q R M C N
27
++ L S L G N G C T+T K E C Q C N
2
W Y A D L S A S L G N R G S Y C T I T K E C Q A C C N
28
53.3%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S L G N G C T L T K E C Q C N
8
L S D F L G N Q G G W C T L T K E C Q P N C N
30

#### MIBiG 4.0 matches for CWT12_RS00385

53.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
L S L G N G C T L T K E C Q C N
8
L S N A L G N N G G W C T L T K E C Q P N C N
30
46.4%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
+S +L G N G C T L T E C C N
6
I S C R L G N K G A Y C T L T V E C M P S C N
28
23.1%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
16
C T L T K E C Q R M C N
27
C T L+K E C Q C N
28
C T L S K E C Q P N C N
39
CWT12_RS00390
Leader:
MTHENLTGTYTASELEELNDISAYG
Core:
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
Core with dehydrations:
G Dhb Dhb P Dha Dha W P Cys G I G I Dhb Dhb Dhb V Cys P Dhb A A Cys Dha Dha K Cys R

#### antiSMASH-DB 4.0 matches for CWT12_RS00390

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide
Lanthipeptides: CWT12_RS00390_lanthipeptide
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
28
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
28
89.3%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C R
28
G T T P S S W P C G I G I T T T+C P T A C+S K C R
1
G T T P S S W P C G I G I T T T I C P T A V C T S K C R
28
46.9%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide
Lanthipeptides: BALI_RS00915_lanthipeptide
2
T T P S S W P C G I G I T T T V C P T A A C S S K C
27
T T P S S P C G +T C P+ A C+S C
7
T T P S S L P C G T L V T A V W C P S N A C T S D C
32
with 90 more sequence matches
Only the first 10 are displayed here.
46.4%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide
Lanthipeptides: LDO05_RS02090_lanthipeptide
3
T P S S W P C G I G I T T T V C P T A A C S S K C
27
T S S W C G+ + C P+ A C+S K C
5
T T S S W I C G V A-S A A F C P S T A C T S K C
28
43.8%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
2
T T P S S W P C G I G I T T T V C P T A A C S S K C
27
T T P S S P C G+ +T C P+ C+S C
7
T T P S S L P C G V F V T A A F C P S T K C T S S C
32
43.8%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
2
T T P S S W P C G I G I T T T V C P T A A C S S K C
27
T T P S S C G I ++ C P T C+S+C
7
T T P S S V A C G I A V S A L F C P T T K C T S Q C
32
42.9%
NZ_BIFH01000022.1 and 1 other:
NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS52585_lanthipeptide
Lanthipeptides: EMA17_RS52585_lanthipeptide
13
I T T T V C P T A A C S S K C
27
I T T+C P T A C S S K C
14
I T A T M C P T T A C S S K C
28
42.9%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS18310_lanthipeptide
5
S S W P C G I G I T T T V----C P T A A C S S K C
27
++ P C +G I T T+ C P T C+S+C
2
T T L P C-V G I T V T I S V S M C P T T K C T S Q C
27
41.9%
NZ_CP030280.1 and 3 others:
NZ_CP030280.1 Lanthipeptides: DQQ01_RS15860_lanthipeptide NZ_CP030280.1 Lanthipeptides: DQQ01_RS15865_lanthipeptide NZ_CP030280.1 Lanthipeptides: DQQ01_RS15860_lanthipeptide
Lanthipeptides: DQQ01_RS15865_lanthipeptide
6
S W P C G I G I T T T V C P T A A C S S K C
27
S+ G I T V P T A C S S K C
11
S F I T G I-F T G M V A P T G A C S S K C
31
41.9%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide
Lanthipeptides: C8268_RS00150_lanthipeptide
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C
27
G T S S W C G +T +C P+ A C+ C
6
G I T T S S W I C G F-V T A A L C P S T A C T G D C
31
41.0%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
3
T P S S W P C G I G---I T T T V C P T A A C S S K C
27
T S S W P C I G I+ +C P T C+S K C
12
T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
40.0%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS21935_lanthipeptide
1
G T T P S S W P C G I G I T T T V C P T A A C S S K C
27
G P + P I +T C P+ C S S K C
4
G G V P I T V P I T I A A S T A F C P S I K C S S K C
30
39.5%
NZ_JAHXMW010000012.1 and 3 others:
NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide
Lanthipeptides: KZX51_RS23840_lanthipeptide
5
S S W P C G I-------G I T T T V--C P T A A C S S K C
27
S S W P C I I T + C P+ A C S S+C
7
S S W P C A I V P P V L I W T I T D S A N S C P S T A C S S R C
38

#### MIBiG 4.0 matches for CWT12_RS00390

25.0%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
17
V C P T A A C S S K C
27
C P T C+S K C
16
F C P T T K C T S K C
26
18.9%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
11
I G I T T T V C P T A A C S S K C
27
+G++ C P T C+S+C
21
V G V S A A F C P T T K C T S R C
37
14.3%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
13
I T T T V C P T A A C S
24
+ T V C +C+
11
L L N T V C I G I S C A
22
allorf_0084004_0084123
Leader:
MSLPGGPWDTAERRVEVGR
Core:
E S C R E V G I R E P V W W C R G G V G
Core with dehydrations:
E Dha Cys R E V G I R E P V W W Cys R G G V G

#### antiSMASH-DB 4.0 matches for allorf_0084004_0084123

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: allorf_0084004_0084123_lanthipeptide
Lanthipeptides: allorf_0084004_0084123_lanthipeptide
1
E S C R E V G I R E P V W W C R G G V G
20
E S C R E V G I R E P V W W C R G G V G
1
E S C R E V G I R E P V W W C R G G V G
20
25.0%
NZ_JAINUL010000001.1:
Lanthipeptides: allorf_8079390_8079587_lanthipeptide
6
V G I R E P V W W C R G G V
19
+G +W+C+ G V
3
I G Q S S T I W Y C K T G V
16
allorf_0097382_0097492
Leader:
MRETLGRWIGRARPPGA
Core:
G K G T A C V M S C S R H W C S I G R
Core with dehydrations:
G K G Dhb A Cys V M Dha Cys Dha R H W Cys Dha I G R

#### antiSMASH-DB 4.0 matches for allorf_0097382_0097492

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: allorf_0097382_0097492_lanthipeptide
Lanthipeptides: allorf_0097382_0097492_lanthipeptide
1
G K G T A C V M S C S R H W C S I G R
19
G K G T A C V M S C S R H W C S I G R
1
G K G T A C V M S C S R H W C S I G R
19
29.2%
NZ_KZ559472.1:
Lanthipeptides: CXR44_RS39555_lanthipeptide
5
A C V M S C S R H W C S
16
A C V +C R C S
4
A C V N T C K R T V C S
15
12.2%
NZ_CP032544.1 and 2 others:
NZ_CP050861.1 Lanthipeptides: HER15_RS06230_lanthipeptide NZ_LDOD01000011.1 Lanthipeptides: ACI36_RS12155_lanthipeptide
Lanthipeptides: D6200_RS07485_lanthipeptide
5
A C V M S C S R H W C
15
+C+ S C+R+ C
25
S C I K S C N R N S C
35
with 1 more sequence matches
6.9%
NZ_CP017169.1:
Lanthipeptides: allorf_8034042_8034278_lanthipeptide
10
C S R H W
14
C+R H W
17
C T R H W
21

#### MIBiG 4.0 matches for allorf_0097382_0097492

10.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
G K G T A C V M S
9
K G C ++
12
N K G A Y C T L T
20
allorf_0098372_0098596
Leader:
MIEQSHFG
Core:
P G S E V G E M S I G D A L R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
Core with dehydrations:
P G Dha E V G E M Dha I G D A L R E M V D W A G R V G Dha A G V A Dhb E G L A Dha P R Dha D Dhb D M A M A E R V R R E H M Cys G D F L Dha V V D P V G

#### antiSMASH-DB 4.0 matches for allorf_0098372_0098596

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: allorf_0098372_0098596_lanthipeptide
Lanthipeptides: allorf_0098372_0098596_lanthipeptide
1
P G S E V G E M S I G D A L R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
66
P G S E V G E M S I G D A L R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
1
P G S E V G E M S I G D A L R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
66
45.5%
NZ_CP039292.1:
Lanthipeptides: allorf_0094578_0094799_lanthipeptide
30
A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P V G
66
A G+ S P R S D T D M A M A E R V R R E M C D F L+V V D P V G
1
A A A G V V S P R S D T D M A M A E R V R R E R M C E D F L T V V D P V G
37
22.7%
NZ_CP022098.1:
Lanthipeptides: allorf_01481640_01481861_lanthipeptide
15
R E M V D W A G R V G S A G V A T E G L A S P R S D T D M A M A E R V R R E H M C G D F L S V V D P
64
++ + W G G S G V R D+ A+ E H C G F+ ++ P
8
K Q W M S W W G-A G S G G V H F------R Q G M D L E C A D----E H R C G C F V G M L W P
46
with 3 more sequence matches
13.6%
NZ_LT607733.1:
Lanthipeptides: allorf_2263047_2263265_lanthipeptide
8
M S I G D A L R E M V D W A G R V G S A G V A T E G
33
++I G D L D G++G+A G
12
V T I G D Q L N G Q R D I G G K L G A A H A C G R G
37
10.6%
NZ_LBJF01000016.1:
Lassopeptides: XH87_RS09510_lassopeptide
50
R R E H M C G D F L S V V D
63
R E H G D+ V D
7
R A E H T T G D Y Y Y V D D
20
7.6%
NZ_CP113837.1:
Lanthipeptides: allorf_4171641_4171739_lanthipeptide
51
R E H M C G D F
58
R+H+C D F
1
R D H I C K D F
8
allorf_0098430_0098639
Leader:
MRLERWWIGQEELARQAWRRKDSPAPGA
Core:
I Q T W R W Q R G C E G N T C A V T S Y R L W I R W D S R I L S Y T A V W P A H H
Core with dehydrations:
I Q Dhb W R W Q R G Cys E G N Dhb Cys A V Dhb Dha Y R L W I R W D Dha R I L Dha Y Dhb A V W P A H H

#### antiSMASH-DB 4.0 matches for allorf_0098430_0098639

100.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: allorf_0098430_0098639_lanthipeptide
Lanthipeptides: allorf_0098430_0098639_lanthipeptide
1
I Q T W R W Q R G C E G N T C A V T S Y R L W I R W D S R I L S Y T A V W P A H H
41
I Q T W R W Q R G C E G N T C A V T S Y R L W I R W D S R I L S Y T A V W P A H H
1
I Q T W R W Q R G C E G N T C A V T S Y R L W I R W D S R I L S Y T A V W P A H H
41
39.0%
NZ_CP039292.1:
Lanthipeptides: allorf_0094630_0094776_lanthipeptide
1
I Q T W R W Q R G C E G N T C A V T S
19
I+T W R W Q R G C E G N C A T S
1
I R T W R W Q R G C E G N A C A R T S
19
14.6%
NZ_LT629701.1:
Lanthipeptides: allorf_4965071_4965214_lanthipeptide
8
R G C E G N T
14
R G C E G+T
20
R G C E G S T
26

#### MIBiG 4.0 matches for allorf_0098430_0098639

9.8%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
10
C E G N T C A
16
C G +C A
16
C I G I S C A
22

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (3):
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.68 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.98 out of 32.74
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

CWT12_RS00385 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 3122.5 Da
  Molecular weight: 3124.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3142.7 Da N = 1
CWT12_RS00390 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 2604.3 Da
  Molecular weight: 2606.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2624.0 Da N = 1
    2642.0 Da N = 2
    2660.0 Da N = 3
    2678.1 Da N = 4
    2696.1 Da N = 5
    2714.1 Da N = 6
allorf_0077306_0077500 - Class II
  Cleavage pHMM score: -1.60
  RODEO score: 0
  Monoisotopic mass: 4060.0 Da
  Molecular weight: 4062.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4080.5 Da N = 1
allorf_0084004_0084123 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 2256.1 Da
  Molecular weight: 2257.5 Da
  Number of bridges: 1
allorf_0097382_0097492 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 1965.9 Da
  Molecular weight: 1967.3 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1985.3 Da N = 1
allorf_0098372_0098596 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 6774.2 Da
  Molecular weight: 6778.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6796.5 Da N = 1
    6814.6 Da N = 2
    6832.6 Da N = 3
    6850.6 Da N = 4
    6868.6 Da N = 5
    6886.6 Da N = 6
    6904.7 Da N = 7
allorf_0098430_0098639 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 4876.5 Da
  Molecular weight: 4879.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4897.5 Da N = 1
    4915.5 Da N = 2
    4933.5 Da N = 3
    4951.6 Da N = 4
    4969.6 Da N = 5
CWT12_RS00385 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 3122.5 Da
  Molecular weight: 3124.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3142.7 Da N = 1
CWT12_RS00390 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 2604.3 Da
  Molecular weight: 2606.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2624.0 Da N = 1
    2642.0 Da N = 2
    2660.0 Da N = 3
    2678.1 Da N = 4
    2696.1 Da N = 5
    2714.1 Da N = 6
allorf_0084004_0084123 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 2256.1 Da
  Molecular weight: 2257.5 Da
  Number of bridges: 1
allorf_0097382_0097492 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 1965.9 Da
  Molecular weight: 1967.3 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1985.3 Da N = 1
allorf_0098372_0098596 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 6774.2 Da
  Molecular weight: 6778.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6796.5 Da N = 1
    6814.6 Da N = 2
    6832.6 Da N = 3
    6850.6 Da N = 4
    6868.6 Da N = 5
    6886.6 Da N = 6
    6904.7 Da N = 7
allorf_0098430_0098639 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 4876.5 Da
  Molecular weight: 4879.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4897.5 Da N = 1
    4915.5 Da N = 2
    4933.5 Da N = 3
    4951.6 Da N = 4
    4969.6 Da N = 5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP025249.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,640,641 - 1,661,858 nt. (total: 21,218 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acyltransferase phosphorylase
CWT12_RS06930: acyltransferase

smcogs
  SMCOG1141: acyltransferase

CWT12_RS14355: thiamine-phosphate pyrophosphorylase

smcogs
  SMCOG1280: thiamine-phosphate pyrophosphorylase

Ligases: synthetase
CWT12_RS06880: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus
BGC0000936.5 |  | 0.37 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4 |  | 0.36 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001456.3 |  | 0.36 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.36 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002578.2 |  | 0.35 | other (other) | gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F | Streptomyces venezuelae ATCC 10712
BGC0000644.3 |  | 0.35 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000633.3 |  | 0.35 | terpene | carotenoid | Streptomyces avermitilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus
BGC0000936.5 |  | 0.37 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4 |  | 0.36 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001456.3 |  | 0.36 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.36 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002578.2 |  | 0.35 | other (other) | gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F | Streptomyces venezuelae ATCC 10712
BGC0000644.3 |  | 0.35 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000633.3 |  | 0.35 | terpene | carotenoid | Streptomyces avermitilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
CWT12_RS06880: PT_FPPS_like
Domain 1 (73 - 404): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (3):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.07 out of 36.54
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.61 out of 26.85
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.37 out of 28.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---