LOCUS       NZ_CP028217            21612 bp    DNA     circular CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain SRCM102751 chromosome, complete genome.
ACCESSION   NZ_CP028217
VERSION     NZ_CP028217.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4047680)
  AUTHORS   Jeong,D.-Y.
  TITLE     Bacillus subtilis SRCM102751 having probiotics activity species
            isolated from korea kimchi
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4047680)
  AUTHORS   Jeong,D.-Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAR-2018) Functionality Evaluation Team, Microbial
            Institute for Fermentation Industry, Minsokmaeul-gil 61-27, sunchang
            56048, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v3.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 253.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009913575.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:39:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,183
            CDSs (total)                      :: 4,062
            Genes (coding)                    :: 3,965
            CDSs (with protein)               :: 3,965
            Genes (RNA)                       :: 121
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 59 of 97
            Pseudo Genes (incomplete)         :: 47 of 97
            Pseudo Genes (internal stop)      :: 16 of 97
            Pseudo Genes (multiple problems)  :: 21 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:23:30
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1321073
            Orig. end                         :: 1342685
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP028217.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21612
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /region_number="5"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     cand_cluster    1..21612
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21612
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11612](-)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11612)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     gene            complement(420..539)
                     /gene="phrF"
                     /locus_tag="C7M29_RS06835"
                     /old_locus_tag="C7M29_01351"
     CDS             complement(420..539)
                     /codon_start=1
                     /gene="phrF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391627.1"
                     /locus_tag="C7M29_RS06835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01351"
                     /product="phosphatase RapF inhibitor PhrF"
                     /protein_id="WP_009968329.1"
                     /transl_table=11
                     /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI"
     gene            complement(523..1668)
                     /gene="rapF"
                     /locus_tag="C7M29_RS06840"
                     /old_locus_tag="C7M29_01352"
     CDS             complement(523..1668)
                     /codon_start=1
                     /gene="rapF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391626.1"
                     /locus_tag="C7M29_RS06840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01352"
                     /product="response regulator aspartate phosphatase RapF"
                     /protein_id="WP_161476632.1"
                     /transl_table=11
                     /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQMEE
                     DQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYYFN
                     FFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFSMDY
                     ARQAYEIYKENEAYNIRLLQCHSLFATNFLDLKQYEDAVSHFQKAYSMAKAEKQPQLMG
                     RTLYNIGLCKNSQSQYEDAITYFKRAIAVFEESNILPSLPQAYFLITQIHYKLGKMDKA
                     HEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYADLEDFA
                     IDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV"
     gene            1671..1901
                     /locus_tag="C7M29_RS21110"
     CDS             1671..1901
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009968328.1"
                     /locus_tag="C7M29_RS21110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_041334639.1"
                     /transl_table=11
                     /translation="MQIPPFIILYMSYFIINILVRSAKKPQFFLSLHRMFGDIFSKRSV
                     YPQQFVQANTLLFHILLYLREQCMSEKEVKE"
     misc_feature    complement(1701..1717)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.81"
                     /tool="antismash"
     gene            1898..3253
                     /gene="ywhK"
                     /locus_tag="C7M29_RS06850"
                     /old_locus_tag="C7M29_01353"
     CDS             1898..3253
                     /codon_start=1
                     /gene="ywhK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391625.1"
                     /locus_tag="C7M29_RS06850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01353"
                     /product="YncE family protein"
                     /protein_id="WP_046381402.1"
                     /transl_table=11
                     /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFVV
                     DPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRNQY
                     GQGDGAVSVIHNAEIDQVVYYSDEPDDCPDISDITIENLVVVPPFYGSPLSVTGTIVLV
                     PEPEPVYAFTANPNDQSVSVIDTNTHTVVTTIALPYNPAGIEITPDKSAVFVLHPNNNV
                     ISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRSIPVEG
                     YDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAYVLEQEF
                     FFNYLTVIDLNTFTISSTQDLEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPNGAGVIGN
                     VPQSARDFAFTPNGEFLYATHVLEQSITVYNTDDYSVETVISLGVSPGAIAI"
     gene            3293..4669
                     /gene="ywhL"
                     /locus_tag="C7M29_RS06855"
                     /old_locus_tag="C7M29_01354"
     CDS             3293..4669
                     /codon_start=1
                     /gene="ywhL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391624.1"
                     /locus_tag="C7M29_RS06855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01354"
                     /product="YncE family protein"
                     /protein_id="WP_161476633.1"
                     /transl_table=11
                     /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEAS
                     VAVTWSTDNVSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGNGA
                     VSVIHTEEIDQVVYYAAQSDRCPDFSQMTVEDLLIVPPFYGSPLTVTGTLVLPPSPDPQ
                     SYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLVSVID
                     NKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPGALDFA
                     LDPNGQYVYTANGSSWSVDKYDANTGQLVESIIDSFEFPSLIATPYAGNFAYVLNGELW
                     PKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNLYVVNTAR
                     QRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVKVIPVGADPSAIAM
                     "
     misc_feature    complement(3309..3326)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            complement(4675..5376)
                     /gene="albG"
                     /locus_tag="C7M29_RS06860"
                     /old_locus_tag="C7M29_01355"
     CDS             complement(4675..5376)
                     /codon_start=1
                     /gene="albG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391623.1"
                     /locus_tag="C7M29_RS06860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01355"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbG"
                     /protein_id="WP_029726080.1"
                     /transl_table=11
                     /translation="MKKNTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVRL
                     GLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAEDVK
                     SLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPALSMGLAMLLILYLLF
                     CMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSFIYKR
                     FSYRSTASLDL"
     gene            complement(5373..6653)
                     /gene="albF"
                     /locus_tag="C7M29_RS06865"
                     /old_locus_tag="C7M29_01356"
     CDS             complement(5373..6653)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="albF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391622.1"
                     /locus_tag="C7M29_RS06865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01356"
                     /product="pitrilysin family protein"
                     /protein_id="WP_032722698.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 2.5e-13, bitscore:
                     48.2, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDFG
                     SRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNFMF
                     TSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLISMLS
                     PSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPHLQLE
                     KRPDYHAERKIIPACPPALSQKMVLGDEERMEDTWTGLQIGALPGQNDLLAIKLYWDIA
                     ARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYIDVASYYV
                     TQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHIIQDMDAQ
                     VFLSLIDAMASSNKAIIHISQKEAIRQ"
     gene            complement(6658..7818)
                     /gene="albE"
                     /locus_tag="C7M29_RS06870"
                     /old_locus_tag="C7M29_01357"
     CDS             complement(6658..7818)
                     /codon_start=1
                     /gene="albE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391621.1"
                     /locus_tag="C7M29_RS06870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01357"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbE"
                     /protein_id="WP_014478290.1"
                     /sec_met_domain="Peptidase_M16_C (E-value: 4.7e-05,
                     bitscore: 21.4, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYLK
                     EQIIDAFGCAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSFPS
                     SLSFEAVEKARNELLLRIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKAIHP
                     KRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFETETRS
                     AAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHVITRYD
                     VMNNLLLVSICTDQLHEIDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQFDSPEGL
                     LAYMGILRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG"
     gene            complement(7808..9118)
                     /gene="albD"
                     /locus_tag="C7M29_RS06875"
                     /old_locus_tag="C7M29_01358"
     CDS             complement(7808..9118)
                     /codon_start=1
                     /gene="albD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391620.1"
                     /locus_tag="C7M29_RS06875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01358"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbD"
                     /protein_id="WP_161476634.1"
                     /transl_table=11
                     /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQA
                     GIDESVLRKTYIILALLLMNAYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVVLF
                     VDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVKKKN
                     LMFLLHAAIFACVCISVALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHSFMRR
                     SEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISALLLIC
                     SPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFISGRSIS
                     VLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPLFLAILAG
                     TAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS"
     gene            complement(9111..9830)
                     /gene="albC"
                     /locus_tag="C7M29_RS06880"
                     /old_locus_tag="C7M29_01359"
     CDS             complement(9111..9830)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="albC"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391619.1"
                     /locus_tag="C7M29_RS06880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01359"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_017696261.1"
                     /transl_table=11
                     /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTT
                     LINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVS
                     FVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILD
                     EPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILDNKQIQKVIPI
                     GEETDLRREFFEVIGHE"
     gene            complement(9827..9988)
                     /gene="albB"
                     /locus_tag="C7M29_RS06885"
                     /old_locus_tag="C7M29_01360"
     CDS             complement(9827..9988)
                     /codon_start=1
                     /gene="albB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391618.1"
                     /locus_tag="C7M29_RS06885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01360"
                     /product="antilisterial bacteriocin subtilosin biosynthesis
                     protein AlbB"
                     /protein_id="WP_003222006.1"
                     /transl_table=11
                     /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGM
                     RARKADSR"
     gene            complement(10001..11347)
                     /gene="albA"
                     /locus_tag="C7M29_RS06890"
                     /old_locus_tag="C7M29_01361"
     CDS             complement(10001..11347)
                     /codon_start=1
                     /gene="albA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391617.1"
                     /locus_tag="C7M29_RS06890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01361"
                     /product="subtilosin maturase AlbA"
                     /protein_id="WP_085185524.1"
                     /sec_met_domain="subtilosin (E-value: 0.0, bitscore:
                     1079.3, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 5e-29,
                     bitscore: 98.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.3e-07, bitscore: 28.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.5e-44, bitscore:
                     150.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.4e-06, bitscore: 24.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.1e-21, bitscore: 75.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.1e-10, bitscore:
                     37.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.6e-09, bitscore: 36.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLN
                     KTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRASR
                     RTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADMLFDN
                     GVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQKIIVG
                     ISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHDMAQKV
                     RDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHHKFMEYEQNVIDEFKDLIPIIPYERKR
                     AANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLWQAQAPRF
                     SEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI"
     aSDomain        complement(11057..11332)
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C7M29_RS06890_Subtilosin_rSAM_RRE.1"
                     /evalue="3.40E-31"
                     /identifier="RREFam018.1"
                     /label="C7M29_RS06890"
                     /locus_tag="C7M29_RS06890"
                     /protein_end="97"
                     /protein_start="5"
                     /score="98.4"
                     /tool="antismash"
                     /translation="MFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDLNKTAYE
                     LCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQ"
     gene            complement(11372..11524)
                     /gene="sboX"
                     /locus_tag="C7M29_RS06895"
     CDS             complement(11372..11524)
                     /codon_start=1
                     /gene="sboX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_054594.1"
                     /locus_tag="C7M29_RS06895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin-like protein SboX"
                     /protein_id="WP_010886632.1"
                     /transl_table=11
                     /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIHT
                     QPFFI"
     gene            complement(11481..11612)
                     /gene="sboA"
                     /locus_tag="C7M29_RS06900"
                     /old_locus_tag="C7M29_01362"
     CDS             complement(11481..11612)
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="sboA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: Subtilosin_A"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391616.1"
                     /locus_tag="C7M29_RS06900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01362"
                     /product="subtilosin A"
                     /protein_id="WP_003222002.1"
                     /sec_met_domain="Subtilosin_A (E-value: 8.8e-29, bitscore:
                     97.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
     CDS_motif       complement(11583..11612)
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MKKAVIVENK"
                     /locus_tag="C7M29_RS06900_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       complement(11481..11582)
                     /prepeptide="core"
                     /locus_tag="C7M29_RS06900_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="33.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAVIVENK"
                     /leader_location="[11582:11612](-)"
     misc_feature    complement(11703..11718)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.99"
                     /tool="antismash"
     gene            11925..12353
                     /gene="ywiB"
                     /locus_tag="C7M29_RS06905"
                     /old_locus_tag="C7M29_01363"
     CDS             11925..12353
                     /codon_start=1
                     /gene="ywiB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391615.1"
                     /locus_tag="C7M29_RS06905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01363"
                     /product="DUF1934 domain-containing protein"
                     /protein_id="WP_003243604.1"
                     /transl_table=11
                     /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYYE
                     EHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKSIQ
                     SDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA"
     gene            12350..14020
                     /gene="argS"
                     /locus_tag="C7M29_RS06910"
                     /old_locus_tag="C7M29_01364"
     CDS             12350..14020
                     /EC_number="6.1.1.19"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004814 - arginine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006420 - arginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391614.1"
                     /locus_tag="C7M29_RS06910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01364"
                     /product="arginine--tRNA ligase"
                     /protein_id="WP_147797738.1"
                     /transl_table=11
                     /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHGD
                     YSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTKLI
                     PSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAGYDV
                     SREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEYGDRF
                     VNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKALDALRE
                     KGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDKLINVWG
                     ADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVTMRDLIEE
                     VGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQGEEQGLKP
                     AADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASALHSFYNAEK
                     VIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM"
     misc_feature    complement(14076..14091)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            14156..15343
                     /gene="narK"
                     /locus_tag="C7M29_RS06915"
                     /old_locus_tag="C7M29_01365"
     CDS             14156..15343
                     /codon_start=1
                     /gene="narK"
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391613.2"
                     /locus_tag="C7M29_RS06915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01365"
                     /product="nitrate transporter NarK"
                     /protein_id="WP_014478287.1"
                     /transl_table=11
                     /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEIS
                     LVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGGFF
                     LGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKSTVQ
                     MYLVLLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAFVAFT
                     IYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFAGLTLS
                     GIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAMGGLGGF
                     FPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQSIN"
     gene            15441..16157
                     /gene="fnr"
                     /locus_tag="C7M29_RS06920"
                     /old_locus_tag="C7M29_01366"
     CDS             15441..16157
                     /codon_start=1
                     /gene="fnr"
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391612.1"
                     /locus_tag="C7M29_RS06920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01366"
                     /product="fumarate/nitrate reduction transcriptional
                     regulator Fnr"
                     /protein_id="WP_003227573.1"
                     /transl_table=11
                     /translation="MNFLSVRPSDSDLISSDLHELLESISTKRKMEKHTYLFREGMDAE
                     ELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEVLV
                     INKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSNSYG
                     VERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKRDYLR
                     CEIECENCPLEICNID"
     gene            complement(16189..16908)
                     /gene="ywiC"
                     /locus_tag="C7M29_RS06925"
                     /old_locus_tag="C7M29_01367"
     CDS             complement(16189..16908)
                     /codon_start=1
                     /gene="ywiC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391611.1"
                     /locus_tag="C7M29_RS06925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01367"
                     /product="YwiC-like family protein"
                     /protein_id="WP_029726074.1"
                     /transl_table=11
                     /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYLA
                     VYPVTLALKKKQSKPYQKWMCYYGFPACCFLMISVFHKPPLIWVGVSLLPLFLIHMYFA
                     RRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVKSVI
                     RERKNRTFAYWSWGYHLLLPFLSALFGAGWSFLAFIPSSLRAWFFHGRDWPVKTIGILE
                     IVNACFFLAVMCLFITR"
     misc_feature    16979..16994
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            17052..17528
                     /gene="arfM"
                     /locus_tag="C7M29_RS06930"
                     /old_locus_tag="C7M29_01368"
     CDS             17052..17528
                     /codon_start=1
                     /gene="arfM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391610.1"
                     /locus_tag="C7M29_RS06930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01368"
                     /product="Crp/Fnr family transcriptional regulator ArfM"
                     /protein_id="WP_003243032.1"
                     /transl_table=11
                     /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSFL
                     HSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSDIL
                     ILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS"
     misc_feature    complement(17615..17629)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.64"
                     /tool="antismash"
     misc_feature    17616..17629
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.07"
                     /tool="antismash"
     misc_feature    complement(17638..17653)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            17719..21405
                     /gene="narG"
                     /locus_tag="C7M29_RS06935"
                     /old_locus_tag="C7M29_01369"
     CDS             17719..21405
                     /GO_component="GO:0009325 - nitrate reductase complex
                     [Evidence IEA]"
                     /GO_function="GO:0008940 - nitrate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009061 - anaerobic respiration [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="narG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391609.2"
                     /locus_tag="C7M29_RS06935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M29_01369"
                     /product="nitrate reductase subunit alpha"
                     /protein_id="WP_161476635.1"
                     /transl_table=11
                     /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRWQ
                     YDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGASFS
                     WYIYSPLRVKYPYVRGVLINLWREALQEHQNPLEAWKSIVENPEKAKSYKQARGKGGFV
                     RAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPMLSFY
                     DWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEARYKGAK
                     VISISPDFAESSKFADDWLSIRQGTDGALAMAMGHIILQEFYVNQETERFIEYAKQYTD
                     FPFLVTLSKENGVYTAGRFLHAKDIGRQTKHDQWKPAVWDEQTSSFAIPQGTMGSRWDG
                     QQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLPIKKMNLNG
                     EETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKEAVVKIAREF
                     AQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGWAHYVGQEKLR
                     PAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPIAASSRYKHHAD
                     YNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQLQEKKLKFAIEDP
                     DNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDSIRPEEIKWREQAP
                     EGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFIHPFAPAISAPWESK
                     SDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQPFGKINDWSKGECEAI
                     PGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSIADEYESLKQRLGEITS
                     DSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENITNLKLKDLAEEREEECF
                     TFEQITAQPKTVITSPAFSGSEKGGRRYSPFTTNVEKLIPWRTLTGRQSYYVDHELMME
                     FGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKWSVHSMYFDSLPMLTLFRGG
                     PTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHRIPKGMAFMHHAQDRHINVPG
                     TKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYYGPTGNQRDLNVVIRKLKEVDW
                     LED"
     misc_feature    21483..21497
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.21"
                     /tool="antismash"
ORIGIN
        1 atgagccaac ccaaatgggc aaacacctcc aatttcatgg cctgtctgct ccagtacctc
       61 attaggagag agcattcttg ctttaaagcc aaatatttgc ctgaactttt tgttattaat
      121 cttggcatcg ccggctgcca caatcagaat cacctgatct ccttcccctc tgaaggacag
      181 ggtcttggcg attctagtcg ggcttacgcc gatcgtctca gctgtctgtt caacactgtc
      241 gcgctcgacg tttcgaactc cgtcacatca ttttctcgat tccactgtgt aaagtgggtt
      301 ctcacacttt acagagacat gctgcatttc cactctcttc aagattattg aaaaaaatca
      361 tagcatgaat tgggagattg ggtaaagagg ggacaaaaaa aaccgccgat ggacggcggt
      421 taaatcattc ctcgttgtgc aacttcaatt tggtgtgtag gtgcatttgc aatagttgtt
      481 gccacgaaca cagtgcttag agccagacaa gagagtaata gtttagactt caatttcata
      541 caaactcact cctccttgaa taagttgcct tacttgttcc accttcaaaa aataagcaga
      601 agctttttga aaatttttac gttcatgata atattttgcc acatcaatag cgaaatcttc
      661 aagatcagca tacaacattt tactttcgag aaaatcaaaa aatccttgaa ttgcttcttc
      721 atccgggcct gataagtata aagatttcaa aaattcaaac tctgataaat atattacatc
      781 tccggccttt tgtgaataag ccattccctt actatggtat tcatgagctt tatccatttt
      841 tcctaattta taatggatct gtgtaattaa aaaatacgct tgaggtaagg aaggaagaat
      901 atttgattct tcaaaaacag ctattgctct tttgaaataa gttatggcat cctcatattg
      961 gctttggctg tttttacaaa gcccgatatt gtacaaagtt cttcccatta attggggctg
     1021 cttttcagct tttgccatag aataagcttt ttgaaaatgt gagacggcat cctcatactg
     1081 ttttaaatct aaaaaattgg tggcaaataa agaatgacac tgcagcaatc ttatattata
     1141 agcttcattt tctttgtata tttcatatgc ttgccgtgca tagtccattg aaaaatacgt
     1201 ttgtttcata tagtaataag attcagacat cttaaagaaa aactcagctt tctctatccg
     1261 atccttaacg aatatcagct tgctttcggc ctttttgaaa aatttaatag ccgacagata
     1321 ttcccgctga tccagctcat acatgcctct gaagaaatta aaatagtact caagcagacc
     1381 agttaaacga gcctgttttt tatcaatctc aagcagcaga tcagacagtc tcggctgttc
     1441 ctcaatcctc attttttcta acggttcaag gtactcaagc attaggttgt gccgaaactc
     1501 catcagtgaa tagtacaaat gaaggtcttg atcttcttcc atttgatcca gctcttgctt
     1561 gatttctcgt cgcaaatatt ctgcatcggg tatgctgaat cggcgtatgt acatatacca
     1621 ttcgttaatc ttttctccga tggaagaaga agatatgaca cctgtcacgt ttgcaaatcc
     1681 ctcccttcat aattctatat atgtcatatt ttatcatcaa cattcttgtg agaagcgcaa
     1741 aaaaaccgca attttttctt tcgttacacc gcatgtttgg agatatattt tcaaaaagaa
     1801 gcgtttaccc tcagcaattt gtacaagcaa acacgttact cttccatatt ctgttatatc
     1861 tgcgtgagca gtgtatgtct gaaaaggaag tgaaggaatg agaaaaaata agctttcctt
     1921 taaagaaaaa gcaggagcag aacaagaaga gtgcttatgt ttttgtgagg gagaagcaag
     1981 ccgagaagcc atgtttcaag cgccgattga attacctgaa ggatttgtcg ttgatccggc
     2041 tgaagctgtt gcaaacgtga cgtggaatgc agacagcctt tcttgtgtca gtgaccgttg
     2101 cttaattcaa acggggccag agcctgatga ggtcggtgtt caatttgcag tgcgcctgca
     2161 gggaaccgtt acgctactcg tcagtgtctc acctgtgcga aatcaatatg gacaagggga
     2221 cggggctgtt tccgtcattc acaatgcaga aatcgatcaa gtcgtctatt attccgatga
     2281 accggatgat tgcccggata tcagtgacat cacgattgag aaccttgttg ttgttccgcc
     2341 gttttacggc agtcctttat cggtgacggg gacgattgtg cttgtaccgg agccggaacc
     2401 cgtctacgcg tttacagcga atccaaatga tcaatcagtt tctgtgattg atacaaacac
     2461 ccatactgtt gtgacaacga ttgctcttcc gtacaatccg gcaggtattg aaattacgcc
     2521 agataaaagc gctgtgtttg tcttacatcc caacaataat gtgatttctg tcatcgatta
     2581 tgacacatta acagtgacag caactatatt gctggatcag ccgcctcgat tgattagatt
     2641 tatccctaat catgagtttg cttatgtttt caccggtact gcggtttatg tgattggaat
     2701 tgatacgtta actgtggata ggtcgattcc tgtggaagga tatgatgttg caatcgatcc
     2761 caatgggtta ttcgcctatg ttctgaattt tggaatagtg caaaaagtgg acctaactac
     2821 cggtgaagtc acaggaacaa ttgaacgaga gcttatcgta tcaaccatag aaacaaattg
     2881 gccggagcgg tatgcctatg tattagaaca agaattcttt tttaattatt tgacggttat
     2941 tgatttaaat acgtttacca tcagcagcac ccaagatctg gagtatgaag gggaatatcg
     3001 aatgtttacg agtggagcag aggtgtattt atatgacggc ttcactggca atttatattc
     3061 tgtcagtcca aatggagcag gcgttatagg aaatgttccg cagtcggcaa gagactttgc
     3121 gtttaccccg aatggcgagt ttctgtatgc aactcatgtt ctagaacaga gcatcactgt
     3181 ttacaacacg gatgattact ccgtggagac tgtcatatct cttggggttt caccgggagc
     3241 tattgcgatt taatcaacta tatgttgtgc atttctaaaa ggacgtgaaa tcatgaaaaa
     3301 gaatgatctt tctgctttac aggaaaattg tttctgtttt tgtgatgagg aaattagccg
     3361 ggaagcgccg tttcaagtgc cgatagattt ccctgagggc ttcaaggttg atacggccga
     3421 agcgtcagtg gctgttacat ggagtacaga caatgtgtcc tgtatcagtg agccttgctt
     3481 aatccagact gggccggaac cagaagatat cggtgttcga tatgctgtga gagtacaagg
     3541 gaccattacg cttcttgtca gtgtgtcgcc tgtgcgaaat caatatggac aaggcaatgg
     3601 ggcggtttct gtgattcata ctgaagagat tgatcaagtt gtttattatg cagcacagtc
     3661 tgaccgctgt cctgatttta gtcaaatgac agtggaagat ctgctcattg taccgccttt
     3721 ctacggcagt ccgcttacgg tgaccgggac acttgtttta ccgccatcac cagaccctca
     3781 atcgtatgtg tttactgcca atactggaga cagcacggtt tcggttattg atgcagattt
     3841 aaacactgtt gtaaaaacaa tccctttttc tgacgtgcca actaatctag gcgttacttt
     3901 cgataaagca ttcacgtatg tcctccatgg aaataccaac cttgtctcag tgattgataa
     3961 taaaacatta accatcataa ataccattac tgttggagga gggccgagaa agatcgaatt
     4021 tgatccaaca gatgagttcg catacgtgat ggccgccgga tctatatatg tgattaacac
     4081 ggcctctcaa tcggtcattg atgtcattcc gatacccggc gctttagact ttgctcttga
     4141 tccgaatgga cagtatgtct ataccgctaa tggaagcagt tggtcggttg ataaatatga
     4201 tgcaaatact gggcagttgg tagaaagtat catagattca tttgaatttc ccagtttaat
     4261 tgcaactcct tacgctggaa attttgcgta cgtgttgaat ggtgagctgt ggccgaaagg
     4321 tgtaacggag attagtttgt ctccattaag caggggaggg gacttcagcc gtttatttga
     4381 aacgctgagg acgattgtat tttctctcga tagcactaga gcttattttc tagagccata
     4441 tagtgaaccg tttcttatta ataacttata tgtagttaat acggccagac agaggatcat
     4501 tgcaaacgtg tctctccccg gcgcttttga cctcgccgta acgccggaca aacagtatat
     4561 ttatgcggca cagcccaacg acaatgctgt gactgtgtac cgcacaagtg attatacagc
     4621 cgtgaaggtg attccggttg gcgcggatcc gtctgcgatt gcaatgtagc tattttatag
     4681 atcaagagaa gcggtgctgc gataagagaa tcgtttataa ataaatgatc cgatttgttg
     4741 gatggcagcc aggataatca gaaacagaag ttcacttata gagaaactga gcatccacca
     4801 aatcccggct gctgccagcg ctcccgcaaa cacttttctg aacaggctgc cgtgccggaa
     4861 aagctgccgc aaatatgttc gcatgcaaaa caataaatac agaatcagta gcatcgcaag
     4921 tcccattgaa agggcagggg gcgtgtgaag gcggaaaggg acggctttaa cgatttcgaa
     4981 catgcagccg aatatgatga cttggcacaa cacggcagcc atcacgtatg tttggcggac
     5041 gtttttatag ctgtcacgca gcgatttgac gtcttctgca tatcggctgc acaagttgtg
     5101 ttgctgaaag tcacagcagc tttgatgaga ctgtgtgagt ttctgaaaag ctgctgtcat
     5161 gtttttcacg gattgggtga cataatgaag atagagaaaa gcaggcagca tcaggagggc
     5221 agcggtacaa gccagcagcc cgagccgcac agcatcattg ttgatcatct gtacatattg
     5281 ggcggcggct tcggcaacgg cctgaaccca gccgaaggaa taagccgcca tacctataag
     5341 cagcaataaa agggtaaaga cagtgttttt tttcattgtc tgatcgcctc tttctgagaa
     5401 atgtgaatga tcgctttgtt agaagatgcc attgcatcaa tgagagacaa gaaaacctgc
     5461 gcatccatat cttgaatgat gtggtacatg tcaagaaacg agcaatcgca cctgtcacac
     5521 tcggctgccc actcgaagca tttacgcaca taatcgctgt cataaatgat cgcgtctgtc
     5581 aaagagtcct tgccgtattg aagccaggcg gcaacctgtt ctttcttctg tgtgacatag
     5641 tatgaagcca catcgatata agctgaagaa tgggtccctt gactgtgaag gatcaagaaa
     5701 ccgccatcct catagatata agtctcggct gacaaacgat cgatttctag gcggtacgtt
     5761 tgctgaatct cttgaaaaaa cggtgaatct aattgaaata gaatacgagc cgcgatatcc
     5821 caataaagct ttatcgccaa cagatcgttt tgcccgggaa gtgcgccgat ctgtaatccg
     5881 gtccatgtat cttccatccg ctcctcatca cccagcacca ttttttgtga gagggctgga
     5941 gggcatgccg ggatgatttt tctttcagca tgataatccg gacgcttttc cagctggagg
     6001 tgaggaggca aaagcgtttc tgtattttct gagcccccaa tcaaaaacag cgtcatccga
     6061 tgggcttggt aggcagcctt ataggctttt tgtaaatcac tgatgtccag cgcctcaata
     6121 tcttcgattc tgcctgcggg gaaaacggca gctggtgagg agggagaaag catgctgatc
     6181 agctgataat gatatgagag ctgatggtta aggtgtgctg tttgaatttc gcttgtaatc
     6241 acagcttttt cctgagcgac aatcttcttg tcaaatgagt ggttccataa agcatcaagc
     6301 aggatgggga tcgtttgtct gagccgatcc ggtaatgagg taaacatgaa attggtatcg
     6361 gtgtaggtag tgaatgcgtt taaaagcgcg ccatgcgcaa aaaaatcact gtacagattg
     6421 cggccgttat gccagaagag aagatgctct aaaaaatgcg ctgtgccata cggaagcagt
     6481 gtatcaccgg attctgcccg tatacataca tcccggcttc caaaatcgat ttttacattg
     6541 cacagccgca ggtgggcgcg ggggaatttc aatctgaata tttttagtcc gctgtctgtg
     6601 tatctgatat cggttcgttc atccagctgt tgaaaaaagg ctttcttttc catctcttca
     6661 tccccttact acatgagctc cgatataatt gatggtcgct atgaattgca atacatcacg
     6721 gcatgtaacc gctgagatgc catccagcaa ggcttctttc gtgcaggaga agcggcgcag
     6781 gatccccata taggccaata ggccttcggg agaatcgaat tgcagcagca attcattgcg
     6841 taaaaactgc tttgcctgtt ctagttcccg ctcatctgta tgaaaagctg agacagcttc
     6901 caaaacgcgc gggggaatgt ctatctcatg aagctgatct gtacatattg aaacaagcag
     6961 caaattgttc atgacatcgt aacgggtgat aacgtgatag actgccagat ccttctctct
     7021 gaagtgcttg aataaagcgg aatggccgta ctttcccagt aatccgtcta ttagctgtat
     7081 tttgatataa tcgctggcat ctttcatctc tccgcagtca aatccgagtg tcaagacgga
     7141 agggcctgca gcgctgcgtg tctctgtttc aaaaacatgc cggtttacgg gtattcttcc
     7201 ggacgttaca gcggacgttt gcggggcatg tccccgaaca tcacatgctt gtacttgtcc
     7261 caatatgttc agctgttttt gctgggacac taaatcaacg ataaagtccg ttgcgtcgag
     7321 aaaccgttta ggatgaatcg cctttatcct gtctctccgg ccaaacatgc ctgtgccgta
     7381 catcgggttt ccgaagacct cctcagccaa gcgcgccgcc gagtaggaga agggatcagt
     7441 gaatttcttt tcgattctca gcagcagctc attcctggcc ttttcaactg cttcgaatga
     7501 aagagaagaa gggaaagaca agtctgcaaa agttttcatc agggcgtcaa catgaagatt
     7561 cccgttatat aatgggtgaa tcaaacgggt cccgcaggtt ttcagctgct gatcaaaaaa
     7621 gagattcgct gagtacatga aacggctgcc ggcagcacaa ccaaaagcgt caatgatttg
     7681 ctccttcagg tatgcggcgg cgccgtaaaa ataaatcgtt tcttcctcag gttccgccgc
     7741 gctttcgatc ggtttcagaa agctcgcggc gattgaaata gttgaaaatt gatgagtctt
     7801 cagcaggtta acttccaagc cgttctcttt tgcttgtatc aaagaaacca ccatcctgtt
     7861 tttgcaggta atagactatg accagaccgg ctatcggaat gaccgccaag gatacagcgg
     7921 tgccggctaa tatggctaag aataggggaa gacaaaacag ataagaccga tattttgaga
     7981 aaccgctcca tagctgctgc tccgtctgcc agctgaagga gggccttttt tcatccgcag
     8041 ttaacctgat atacgctccc gccagcagca actcaatgca ctgcaaaaaa gtgagaactg
     8101 aaatcgaacg gccgctgatg aaacccacaa tcatcacgac aaggagaaat ccgcctgcca
     8161 ataggcctga ataaaagcga tatttcgccc aaaacatcgt ttttcgcttg atcggaagcg
     8221 tgatgagcag catccggtca tttttttcaa tcgaatacaa aagggcgatc ggcgagcaga
     8281 tgagcaaaag cgcggaaatc acgatataaa tcacttgctg attgaagatg ccggtgttca
     8341 tcatctggaa cgaaaagaag ccgctgaata ccgccattac cgcgtaattt aacagcatcg
     8401 ctttagaaga gataaatcgg ttccattctc ttttgtaaaa cgaaaattca gatcgccgca
     8461 taaatgaatg catcttgccc tgctgcggag gcgcctgcag aaagacagga aagtcaatga
     8521 ccaccgccca caggatatga accgcgcaaa gcggaatcgt ggcggccggc atcaaagcga
     8581 cgctgataca tacacaggcg aatatcgccg catgcagcag aaacatcaag ttcttctttt
     8641 tgacgaagtg gttgcttagc acaactccga aaataatgga gtaaacggta aaaaacgaaa
     8701 acctgccgag ccaaaacaat gtttgcgccc ctgacagcgt tccgtttcca aataagaaca
     8761 gcggtaaaat aaaaaagaat aaagttcttc tcaaacaggt atcgacaaac aaaacgacac
     8821 tctgggcgag ccaaaagctc cgtgaagaaa tcggcagcag gcagctcagt ttcatataag
     8881 attccttcca ttgagatgtc acagaaagaa acaccatata tgcgttcatt aagagaagcg
     8941 cgagtatgat atacgttttg cgcaacaccg attcatcaat gccggcctgg cgaatcagcc
     9001 cgatttcaaa cacggccaga atgacaaggc ctgcggcaat gcggatggcg tcctttttcc
     9061 cttgccggct gtaaagctgt ttgaacagca aagacatgat ggggattatg ttattcatgg
     9121 ccgatcacct cgaaaaattc ccgccgcaga tcggtctcct ctccaatcgg aatgaccttt
     9181 tggatctgtt tgttgtcaag aatagccgcg taatcacaaa atctttgcac gacatcgagc
     9241 agatgagaag aaaacaaaat ggtcccgcct gcttcacagt actcgcgcat tttctgataa
     9301 aagacctcta tcgattccac atccaaaccg acgagcggct catccaaaat aaatagggga
     9361 gcgcgcagca ataagcctgt catcaataca accttttgcc tgttccccaa ggacagctcc
     9421 gaaattctcc tgttgatgta tttcgaaaaa tgaaaggcct cggccaaact ggcaaactgc
     9481 tgctctgaaa aatccttttg ataaagcgaa tggacgaaag acacatagtc cttcgccgta
     9541 atttctgtaa atagcagcgg ataatcggcg gcgaagtaac ggtgagtctt cagctgatct
     9601 gatgttttct gcggcatgcc ggcctccgct tcaattccgc acagtgtaaa gcgcccgctg
     9661 aaattgcggt tcacgcctgt cagcgtatta atcagtgtcg tttttccggc gccgtttacc
     9721 ccaagcaacc cgtaaacggc gcctttttct aaatgtaaat ctacttgttc taagatgacg
     9781 ttgtcccgtt cataccaaac ggatacatcg tgtatatcca aaatgctcat cgcgagtcag
     9841 ccttccgcgc gcgcatcccg aacagaatgg caatggcaat gaaaatcagc gtaaacagat
     9901 aatcgctttt gacaaaatag acgactgcgc cgatgacaaa gataaatgaa aggatataca
     9961 gtaaaattct tctttgtgct ggtgacaaat cgtttccctc ctaaataagc tggaccacgt
    10021 cttctaattg ttcatttttc gcccaagagc aaatgttttt tcggtgatat ttgttagagt
    10081 tcagcccttt taagtaacag cctccgcaat agccgctgaa cgggcatttg tctttcatgc
    10141 aatgttcact gaaccgcggc gcctgcgctt gccacagttt atggacgaga ggggagttaa
    10201 agatgctttc ataggaatca tgaaaaatat ttcccaatga aaattccttt ggaaagaggg
    10261 cgcaaggacg tacttcgccg aacgggctga tcacaatgga cttccagcca gcgccgcaat
    10321 ttgccgcgcg ttttctctca tagggaataa tcggaatcag atctttaaac tcatcaatca
    10381 cattttgctc gtattccata aacttgtggt gctgctcggc gtctttcgtt ggatggacaa
    10441 tatccctgcc tcttccgaaa tcatcaaccc aattgtaaga gaacgccttc gccccgagat
    10501 cccgaacctt ttgggccata tcgtggattt cccacatgtt tttttcgaag acagacatag
    10561 cgactctgac aaatataccg tggtcactca acaattttat cgttttacaa gtttgggcaa
    10621 aagagccttt tctccctcta aaggagtcat ggacctcgga attgacacta tctagagaaa
    10681 tgccgacgat gattttttgc ttgtaagtct tcaaaagctc caggctctct tttcgcatga
    10741 gtgttccgtt tgttaagaca gcgacttttt tgaacttttt acacacatag tcaagaatct
    10801 cattggcgtt tggatggaca aaaatttctc cgcctgtgat ttcgcatgtc aatacaccgt
    10861 tatcaaacag catatcagcc gtttttttga attgctcaat cgacacggtg ccgagcgctt
    10921 caggtgagct ttccaaataa cagtgggcgc atttcaaatt acagcggtgc gtcagttcaa
    10981 aggtggcgtg caggggcatc ggaaattcat tgcttccgct cgtggtgatt gtacggcggc
    11041 tggcccggtt tccaagctgg atcacctgct tgttctggag catgttgagc atgtcgtaat
    11101 accaatcttt atggtcttcc ggtgattcat catacactgc acattgctca gctaaaatct
    11161 gctcagctgt tttttggcca tccatgcgca tgcagagctc gtaagccgtt ttgttgagat
    11221 ccaaatactc aaagtcagaa atggagacat tatcgcgcaa gtagtcgatt tctaacacgc
    11281 cgccctcagg aagctggtga actcttacac tttcattaat aaatggaaac atctgctcta
    11341 taaacaaaat accatcccct atacatatga ttcaaatgaa aaacggttgt gtatgtatat
    11401 ccaagaggta gattttagtt aaaaattgta atttacttaa aaagggcata gtagaatgac
    11461 tatgcccttt tgggagatcc ttacccccat agaccgaata gacctgttgc accggcaatt
    11521 tcaaaatcag ggataggacc gtccactaga caagcggctc cgatcgagca tgttgcacaa
    11581 cctttgtttt ctacaatgac agcttttttc ataattgaat cctccctttt tttgtttttc
    11641 tagcagatct atgttgtact tttatcttaa aactatcaaa ttactaattc aatacatata
    11701 ttttgaaaaa aatgtgaaaa ggaaatgata gatttcggaa aaatgtaaca tttcctaaag
    11761 gtaattagtg atatgatttt ctcttctata taaggaaatg ctttttatga ggtttatctt
    11821 caaatctgat gagcaatgat ggtaagatag aagcagttga agtttacaaa ccgaatgatt
    11881 atactattca agtcaaagtg gaatgatgaa aaggacgtgt cagaatgaag caagagacac
    11941 cgataacact ccatgtgaag tctgtgatcg aggatgacgg aaaccaagaa gtcatcgaat
    12001 tccgcaccac cggattttac tatgtaaaac aaaataaagt gtatctatct tattatgaag
    12061 aacacgactt aggcaaagtc aaaacgattg tgaaagtaag cgaaggcgaa gtcctggtca
    12121 tgaggtcagg cgctgtcaaa atgaatcagc gtttcgtaac gggagcttcc acaattgcta
    12181 aatataaaat gtcatttggt gagcttgagc tgaaaacaag cacaaaatcg attcaatctg
    12241 atctcgatga agaaaaaggc cgtatcagca tcgcatatga catgcatgtc ggagacgagc
    12301 aggagcattt acataatatg acgatcacgt atgagggagg aactcacgca tgaacattgc
    12361 ggaacaaatg aaggacgtgc tgaaagaaga aatcaaagcg gccgttctga aagcgggact
    12421 ggctgaagaa agccagattc ccaatgttgt tttagaaaca ccgaaagata aaacacacgg
    12481 cgactactca acgaatatgg cgatgcagtt ggcaagagtg gcaaaaaaag cgccgcgtca
    12541 aatcgctgaa gagattgtcg ctcattttga taaaggaaag gcttcgattg aaaaactgga
    12601 tatcgccggc ccgggtttta tcaatttcta tatgaacaat caatatttaa caaagctgat
    12661 tccgtctgta ctggaagcag gggaagcata cggggaaacg aacatcggaa acggtgaacg
    12721 agttcaggta gaattcgtat cagcgaatcc gacgggagac cttcacctcg ggcatgcgcg
    12781 cggggcggct gttggcgatt ccttgtgcaa cgtgctttca aaagcgggtt acgatgtaag
    12841 ccgcgaatac tacattaacg atgcgggaaa ccaaatcaac aatctggcgc tttctgttga
    12901 agtccgttac tttgaagcac tcggattgga aaaaccgatg ccggaggatg gctaccgcgg
    12961 cgaggatatc attgcgatcg gaaagcgtct cgctgaggaa tacggtgatc gtttcgttaa
    13021 cgaagaggaa agtgaacgcc tcgcgttttt ccgtgaatac ggcctgaaat acgagctgga
    13081 aaagcttcgc aaggacttgg aaaacttccg tgtgccgttt gatgtgtggt attcagaaac
    13141 atcactgtac caaaacggaa aaatcgacaa agcgcttgat gcgctccgcg aaaaaggcca
    13201 tgtctatgaa gaagacggcg cgacttggtt ccgttccacg acgttcggcg atgataaaga
    13261 ccgcgtattg atcaagaagg acggcacgta cacgtacctg cttcctgata tcgcgtatca
    13321 taaggacaag cttgaccgcg gctttgataa gctgatcaac gtttggggtg ccgatcacca
    13381 cggctacatc cctcgtatga aagcggcaat cgaagcgctg ggctatgaaa aaggaacgct
    13441 tgaagtagaa atcattcagc tcgttcacct ttacaaaaac ggcgagaaaa tgaaaatgag
    13501 caaacggacc ggtaaagccg taacgatgcg tgacctgatt gaagaagtcg gcttggatgc
    13561 cgttcgttac ttctttgcaa tgcgaagtgc ggacacccat atggattttg acttagatct
    13621 tgctgtatca acatctaacg aaaaccctgt gtattatgca caatacgcac atgcccgtat
    13681 ttgcagcatg cttcgccaag gggaagagca gggacttaaa ccggcggcag atcttgattt
    13741 cagccatatt caatcagaaa aagaatatga tctgctgaaa acgatcggcg gcttcccaga
    13801 ggcagtggcg gaagcagcgg aaaaacgaat tccgcaccgt gtcacaaact atatttatga
    13861 tctggcttct gctctgcaca gcttctacaa cgcagagaaa gtcatcgacc ctgaaaatga
    13921 agagaagagc cgcgcgcgcc tggctttaat gaaggcaacg caaattacgc tgaacaatgc
    13981 gcttcagctg atcggcgtat cggctccgga aaaaatgtaa tcacgatcaa aaggacaaag
    14041 tcttcgggct ttgtcctttt tttatgagaa aaacgtgtga tgtaattcac aatcctgttt
    14101 gccgagtttt tgtatgataa gactgattat tgaatcattg aaaggggcaa gccaaatgat
    14161 caaccgtcaa cacattcaat tatcgttaca gtcattaagc ttggtggcag ggtttatggt
    14221 ttgggtgctg atttcatcac tcatttccca aatcacatta gatattcatt taagcaaggg
    14281 tgagatttct ttggtgacgg cgattcctgt gatcctcggg tcgcttctcc gcattccttt
    14341 agggtattta acgaacaggt ttggcgcgcg gctcatgttt atggttagct tcatcctgct
    14401 tttatttcct gtattttgga tcagtatcgc ggattctctg tttgatttaa tcgcaggcgg
    14461 ctttttctta gggatcgggg gagcggtgtt ttccattggg gtgacctccc tcccgaaata
    14521 ttatccgaaa gaaaagcacg gtgtcgtcaa tgggatttac ggtgcaggaa atatcgggac
    14581 agccgttacg acatttgcag cgccggttat cgctcaagcc gtcgggtgga aatcaaccgt
    14641 gcagatgtat ctggttttgc tggctgtctt tgccttactg cacgttttgt tcggtgacag
    14701 gcatgagaag aaggtcaaag tttctgttaa gactcaaatc aaagccgttt accggaatca
    14761 tgtgctatgg tttctgagcc tgttttattt tattacgttc ggtgcctttg tcgccttcac
    14821 tatctatctg ccgaactttc tggtggagca ttttgggctg aatcctgcag atgccggctt
    14881 gcggacggct ggctttattg cggtttctac gctgctcagg cctgcaggcg gattcctggc
    14941 tgataaaatg agcccgctcc gcatcttgat gtttgttttt gccgggctta cattatcagg
    15001 cattatccta tcgttctcgc cgacaatcgg cctttatacg tttggatcat taaccgtggc
    15061 cgtctgctca ggcataggaa acggaactgt ttttaaactg gtgcctttct atttttcgaa
    15121 gcaagcgggg attgccaatg ggattgtgtc tgccatgggc ggattaggcg gcttttttcc
    15181 tccgctcata ttggcgagtg tgtttcaggc aacaggccag tacgcgatcg ggtttatggc
    15241 gctttcagag gtggcgttag ccagttttgt ccttgtcata tggatgtatt ggcaggaaag
    15301 aatgaaaaca cacacggaga gaaacagcca gagcatcaac taacactggg cattcacaag
    15361 attgttagtt ttttctcgat gggtacaaat caattcacgt tacaataaac acacaacgtg
    15421 actttcttcg aggtgagctc atgaattttc tctctgttcg accatctgat agtgatctta
    15481 tatccagcga tctgcatgaa ctgctggaat cgatcagcac gaaaagaaaa atggaaaaac
    15541 acacgtattt gtttcgagaa ggaatggatg cagaagagct ttatctgatt caatcaggac
    15601 tcattgaaat cggcaagctg acatctgacg gaaaagacct gacgcttaga atctgccaaa
    15661 agcatgatat cgtcggagaa ttaacacttt tcactgaaga accgaggtat atgctcagtg
    15721 caaaagtgct agaggatggc gaggtgctcg tcattaataa aaataagctg gaaaaagaat
    15781 taatccaaaa cggcgctttg acatttgagt tcatgaaatg gatgagcacg cacctccgga
    15841 agattcagtc caaaatcagg gatctgcttc ttcatggcaa aaagggggcg ctctattcca
    15901 cccttatccg tttatcaaac agctacggag tggagcgaag cgacggcatt ctgattaaca
    15961 ttgtcctgac aaatcaggat ttggcaaagt tttgcgcggc tgcacgtgaa agcgtcaatc
    16021 gtatgctcgg agatctccgc aaaaaagggg ttatttcgat agacgaatcc ggaaaaatta
    16081 ttttacacaa gcgggactat ttacgatgtg agattgagtg tgaaaattgc ccgctggaga
    16141 tttgcaatat tgactgaaaa aaacaaggac agcggtgtcc ttgttttttt accttgtgat
    16201 aaacaggcac atgacggcaa gaaagaagca ggcattcaca atttccagaa tgccaatcgt
    16261 ttttacgggc caatcccttc catgaaaaaa ccatgcccgc aagctgctcg ggataaaagc
    16321 gagaaacgac catcctgctc cgaaaagagc ggataaaaag gggagcagca ggtgatatcc
    16381 ccatgaccag tatgcaaatg tcctgttttt tctttcacga atcaccgatt tcacataaaa
    16441 ggaactcccg ataaaaaata aagcagactg caagaaaata aaccaagccc agccgtcaag
    16501 ggttcccatc cccagccagc agctcgcaaa cccgcccgaa caaaagaaca agacacctgc
    16561 aacatcattc aataaggctc gttcgttttt tctgcgggca aaatacatat gtatgagaaa
    16621 cagcggcagt aaagaaacgc ccacccagat gagaggcggc ttatgaaaga ccgagatcat
    16681 caaaaagcag caggcgggaa aaccgtaata acacatccac ttttgatatg gtttgctttg
    16741 tttctttttt aaggcaagcg taacgggata aaccgctaag tataggaaaa gccaaccaag
    16801 gaagagcgga atatgccaaa taacggggcc tcccttgacc atgccgagta aaaatgggat
    16861 cagcagcatc gcccacgccc cgtgctgctt cggaatcagc gccttcatcg aaatcctcct
    16921 tttttctttc attataaatg cagtcaccct cctgataagt gacattcatc atacaggctg
    16981 tgaaatacat cactgctgta caggctcagt cgagctacac taaagctatc cttagcacag
    17041 gaggttttcc tatgaatcag tgtgactatt tattatttct gaaacaactt cctatgttta
    17101 atgaagtgcc tctatccatt gtcgaaacct tgctgaaaaa cggcacgttt atccgcggtt
    17161 catgtgatca gtctccatct tttcttcatt ctcaatctgt ttatattgta ttaaaaggca
    17221 gtgtccgttt tatggacaca aggctccctg aagggtcgaa aaccgttgcg ctgtgggaaa
    17281 aaggcgatgt gtttccgatt gatgaaaaag gcgggcttta tttatcgccc tttatctcag
    17341 tcaatgccac ttcagacatt ctgattctca acatcccata ttacatattt aagaaaatga
    17401 tgtcttatca tccgcagctg caaatgaact ttttggctat gcttcagcaa aatgtttttt
    17461 gttcctatca attatttttg cggtatctgc atacatcaca ggatgaaaac gccgagcccg
    17521 gttcttaaat agagccggtt tttttgatct ttgaaaggcg gctaatgacc caagcgttct
    17581 gcctgaacgc agccttcctt ctcctttgtg tgaacatttt gtgaaaaaag cggagtgtgt
    17641 gacatagttc acaaggaaac acgctgtctc tgtttatagt gaacttagca tcacctgact
    17701 cggaaggagt gaactctcat gaagaaaaag aaaaggagtc cgttgtttag gagattgaat
    17761 tatttctctc ctatcgaaca ccattcaaat aaacatagcc aaaccacccg cgaagatcgc
    17821 gattgggaga atgtatacag aaacagatgg cagtacgaca aagtcgttcg ctccacccac
    17881 ggcgttaact gtacagggtc ttgcagctgg aatatttatg tgaaaaacgg aattgtcacg
    17941 tgggaagggc aaaatttgaa ttatccttca acaggcccgg atatgcctga ttttgaaccg
    18001 agaggctgcc cgcggggggc cagtttttca tggtatatct acagcccgct ccgtgtgaaa
    18061 tatccatacg tgcgcggtgt actgattaat ttatggcggg aggcactgca agaacatcaa
    18121 aatccattgg aagcctggaa atcgatcgtc gaaaaccctg aaaaagcgaa gtcttataaa
    18181 caggcgagag ggaaaggcgg ttttgtgcgc gctgaatggc cggaggtgct gaagctgatt
    18241 tcagcctctc tgctgtatac agtgatgaaa tacgggccag accgaaacgt cggtttttct
    18301 ccgattccgg ccatgtccat gatcagccat gcatcaggct cccggtttat gtcgttaatc
    18361 ggaggcccta tgctcagttt ttacgactgg tatgcggatc ttcctccggc atccccgcaa
    18421 atttggggtg accagacgga cgttccggaa agcagtgatt ggtacaattc cggctatatt
    18481 atcacatggg gctccaacgt tccgttaacg agaacgcctg acgcgcattt tttggcggag
    18541 gcccgctata aaggcgctaa ggtcatttcg atcagtccgg attttgcgga atcctcaaag
    18601 ttcgcggatg actggctgag tattcgccaa gggactgacg gggcgcttgc gatggcgatg
    18661 ggtcacatca ttttgcagga attttacgtg aaccaagaaa ctgaacgttt tattgagtac
    18721 gcgaagcaat acactgattt tccatttctc gtcaccctgt caaaagaaaa tggcgtatac
    18781 acagcgggac gatttctgca tgcgaaggac atcgggcggc agacaaagca tgatcagtgg
    18841 aagcctgcgg tttgggatga acagacaagt tcatttgcca taccccaagg gacaatgggc
    18901 tcgcgctggg acgggcagca gaaatggaac ctgcacatga ttgatgaaga aaccggggaa
    18961 ccgattgaac cccgtctctc tgtgctggga atagaggacg aaatcggcac ggtgcgcatc
    19021 ccgtattttt caaatgacgg gaacaaagtg ctcgagcggg atcttcctat taaaaaaatg
    19081 aacctgaacg gtgaagaaac gtacatcacg accgtgtttg acttgatatt ggctaactac
    19141 ggcgtgaacc ggggtatcgg cgaacgatcg gctgtctcct atgatgatcc tgagccgttt
    19201 acgcctgcct ggcaggaaca aatgacagga atcaaaaaag aagctgtcgt taagattgcc
    19261 agagagtttg ctcaaaatgc gatcgataca gacggccggt ctatgattat cgtaggagcc
    19321 ggcattaacc actggttcaa ctccgacacg atctaccgag cggtgttaaa tcttgttttg
    19381 cttgtaggcg cccaaggcgt aaatggcgga ggctgggccc attacgtcgg gcaggaaaag
    19441 ctccgacctg ctgaaggatg gcagacgatt gcaactgcaa aggactggga gggcgtgccc
    19501 aagctgcaaa acggcacttc atttttctac tttgcgacag atcagtggcg ttatgaggac
    19561 cagccgatca gtgatttggc atcaccgatt gctgcgtcat cccgctacaa gcaccacgct
    19621 gattacaatg tgctggccgc gcggctgggg tggcttccgt cttacccgac tttcaatcaa
    19681 aatggcatcg atctgtataa agaagctgaa aaagcagggg cagcaacacc cgaagacgta
    19741 ggtgcgtacg tggcctcaca gcttcaagag aaaaaactga aattcgcgat tgaagatcct
    19801 gataatgaag tgaattttcc aagaaatctc ttcgtatggc gggcaaatct gatctcaagc
    19861 tcaggaaaag ggcatgaata ttttctcaag catttgctgg ggacgacgaa cggtttgatg
    19921 aatgacgaca gcgacagcat ccgccctgaa gaaatcaaat ggcgggagca ggcgccggaa
    19981 ggaaagctcg acttgttaat caatcttgac ttccgaatgg ccggtacggc gctgtattcc
    20041 gatatcgtgc tgccggcggc gacatggtat gaaaaacacg atctcagcag cacagatatg
    20101 catccgttca ttcatccatt tgctcctgcg atctcggctc cgtgggaatc gaagtcagac
    20161 tgggatattt tcaaggcgct gtcaaaagcc gtttccgatc tggcagaaga agtcgatatg
    20221 gagccggtga aagaagtggt tgcgacgccg ctcctccatg acaccatgca ggaattggcc
    20281 cagccattcg gcaaaatcaa tgactggagc aaaggagaat gtgaagccat tccgggaaaa
    20341 acgatgccga acatccaagt cgttgaacgg gattacaaac acatttttca taaaatgact
    20401 gcacttggtc cgaacgttgc tttaaagccg agcggaacaa aagggatgag ctggtcaata
    20461 gccgatgaat atgaatcact caaacagaga ttgggagaaa tcacctcgga cagtgtcgca
    20521 aagggatgtc caaatataag tgaagcaaag caggcagcag aagcgatttt aaccctatca
    20581 tccacttcga atggaaaggt cgccgtcaaa gcatgggaat cacttgaaaa catcacgaac
    20641 ctgaagctga aagacctggc ggaagaacgc gaggaagaat gctttacgtt cgaacaaatt
    20701 acagcccagc cgaaaacggt gatcacgtct ccagcgtttt ccggctctga aaaaggaggg
    20761 cgcaggtatt cgccgtttac aacaaatgtt gaaaaattaa ttccgtggcg gacgctgaca
    20821 ggcagacaat cctattatgt cgatcatgaa ctgatgatgg aattcggtga aacgatggcg
    20881 acattcaaac cgatcctcca gcatcgcccg tttctgagca agcggcctga tcaagaggga
    20941 aaagaaatcg tcctcaatta tttgacgccg cataacaaat ggtccgtcca cagcatgtat
    21001 tttgattccc tgccgatgct gacgctgttc cgcggcgggc cgaccgtatg gatgaataaa
    21061 gatgatgcag aggatacgga tatcaaagac aacgattgga ttgaatgctt caaccgaaat
    21121 ggcgtagtcg tcgcgagagc cgttttgtct catcggattc ctaaaggaat ggcgtttatg
    21181 caccatgccc aagaccgcca catcaacgtg cccggcacaa agctgacgaa taaccgcgga
    21241 ggcacccata acagcccgac aaggattcac gtcaagccga cacagatgat cggtggatac
    21301 gcccagctca gctacggctt taattattac ggtccaacgg ggaatcagcg cgacctgaac
    21361 gtcgtcatcc gcaagctgaa ggaggtcgat tggcttgaag attaaagcgc aaatcggtat
    21421 ggtcatgaac ttggataaat gcatcggctg ccacacgtgc agcgttacct gcaaaaacac
    21481 gtggacaaac cgttccggtg cggaatatat gtacttcaat aatgtagaaa caaagccggg
    21541 catcggctac ccgaagcaat gggaggacca ggacaaatat aaaggcggct ggacattgaa
    21601 aaaaggaaag ct
//
