GCF_009865985.1 - 2 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_VSTZ01000001.1 (Ligilactobacillus salivarius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	T3PKS,terpene-precursor	667,202	708,365

NZ_VSTZ01000009.1 (Ligilactobacillus salivarius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 33.1	lanthipeptide-class-i	7,023	32,989	Medium	nisin Q	ribosomal:RiPP:Lanthipeptide

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	T3PKS,terpene-precursor	667,202	708,365
Region 33.1	lanthipeptide-class-i	7,023	32,989	Medium	nisin Q	ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:: NZ_VSTZ01000010.1 (Ligilactobacillus salivarius); NZ_VSTZ01000011.1 (Ligilactobacillus salivarius); NZ_VSTZ01000012.1 (Ligilactobacillus salivarius); NZ_VSTZ01000013.1 (Ligilactobacillus salivarius); NZ_VSTZ01000014.1 (Ligilactobacillus salivarius); NZ_VSTZ01000015.1 (Ligilactobacillus salivarius); NZ_VSTZ01000016.1 (Ligilactobacillus salivarius); NZ_VSTZ01000017.1 (Ligilactobacillus salivarius); NZ_VSTZ01000018.1 (Ligilactobacillus salivarius); NZ_VSTZ01000019.1 (Ligilactobacillus salivarius); NZ_VSTZ01000002.1 (Ligilactobacillus salivarius); NZ_VSTZ01000020.1 (Ligilactobacillus salivarius); NZ_VSTZ01000021.1 (Ligilactobacillus salivarius); NZ_VSTZ01000022.1 (Ligilactobacillus salivarius); NZ_VSTZ01000023.1 (Ligilactobacillus salivarius); NZ_VSTZ01000024.1 (Ligilactobacillus salivarius); NZ_VSTZ01000025.1 (Ligilactobacillus salivarius); NZ_VSTZ01000026.1 (Ligilactobacillus salivarius); NZ_VSTZ01000027.1 (Ligilactobacillus salivarius); NZ_VSTZ01000028.1 (Ligilactobacillus salivarius); NZ_VSTZ01000029.1 (Ligilactobacillus salivarius); NZ_VSTZ01000003.1 (Ligilactobacillus salivarius); NZ_VSTZ01000030.1 (Ligilactobacillus salivarius); NZ_VSTZ01000031.1 (Ligilactobacillus salivarius); NZ_VSTZ01000032.1 (Ligilactobacillus salivarius); NZ_VSTZ01000033.1 (Ligilactobacillus salivarius); NZ_VSTZ01000004.1 (Ligilactobacillus salivarius); NZ_VSTZ01000005.1 (Ligilactobacillus salivarius); NZ_VSTZ01000006.1 (Ligilactobacillus salivarius); NZ_VSTZ01000007.1 (Ligilactobacillus salivarius); NZ_VSTZ01000008.1 (Ligilactobacillus salivarius)

Compact view

NZ_VSTZ01000001.1 - Region 1 - T3PKS,terpene-precursor

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Location: 667,202 - 708,365 nt. (total: 41,164 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase methyltransferase

FYK98_RS03530: acyltransferase

smcogs: SMCOG1141: acyltransferase

FYK98_RS03550: methyltransferase

smcogs: SMCOG1248: methyltransferase

Lyases: lyase

FYK98_RS03485: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase synthetase

FYK98_RS03400: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

FYK98_RS03450: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.41	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.37	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.28	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002561.3	0.23	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001605.3	0.22	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000639.3	0.22	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000286.3	0.21	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000642.3	0.21	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.21	terpene	carotenoid	Pantoea ananatis
BGC0000665.5	0.20	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.53	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.50	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.44	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002561.3	0.43	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002645.3	0.41	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0000665.5	0.41	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002007.2	0.40	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0000639.3	0.40	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FYK98_RS03400: PT_FPPS_like

Domain 1 (42 - 301): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.41 out of 20.97

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.66 out of 25.88

Confidence: medium

Additional weak hits (3):

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.60 out of 35.63

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.61 out of 20.47

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_VSTZ01000009.1 - Region 1 - lanthipeptide-class-i

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Location: 7,023 - 32,989 nt. (total: 25,967 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FYK98_RS07435: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

Lyases: cyclase dehydratase

FYK98_RS07450: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

FYK98_RS07465: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000538.3	0.69	ribosomal	nisin Z	Lactococcus lactis
BGC0000536.3	0.69	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.69	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0001789.3	0.68	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.65	ribosomal	nisin U	Streptococcus uberis
BGC0001289.5	0.59	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.58	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.58	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000515.4	0.57	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000549.3	0.57	ribosomal	salivaricin D	Streptococcus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000538.3	0.69	ribosomal	nisin Z	Lactococcus lactis
BGC0000536.3	0.69	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.69	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0001789.3	0.68	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.65	ribosomal	nisin U	Streptococcus uberis
BGC0001289.5	0.59	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.58	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.58	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000515.4	0.57	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000549.3	0.57	ribosomal	salivaricin D	Streptococcus salivarius

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FYK98_RS07450

FYK98_RS07445

Leader:

MSVNDFKLDLVKVSKESTNSNYSVK

Core:

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

Core with dehydrations:

IDhbDhaYDhaLCysDhbPGCysKDhbGALMGCysDhbMKDhbADhaCysGCysHVHIDhaK

antiSMASH-DB 4.0 matches for FYK98_RS07445

100.0%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

91.2%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTASCGCHVH+SK

ITSVSLCTPGCKTGALMGCNMKTASCGCHVHVSK

79.4%

NC_013656.1and 18 others:

NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptideNZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptideNZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptideNZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptideNZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptideNZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptideNZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptideNZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptideNZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptideNZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptideNZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptideNZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptideNZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptideNZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptideNZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptideNZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptideNZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptideNZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide

Lanthipeptides: LLKF_RS13210_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTA+C C +H+SK

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

with 127 more sequence matches

Only the first 10 are displayed here.

79.4%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTA+C C +H+SK

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

76.5%

NZ_JAQDYA010000007.1and 1 other:

NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide

Lanthipeptides: PGT72_RS09560_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTA+C C +H+S+

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

73.5%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09825_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITSYSLCTPGC TG LMGC ++A C HVHISK

ITSYSLCTPGCITGRLMGCQFQSAGCNVHVHISK

70.6%

NC_022237.1and 1 other:

NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide

Lanthipeptides: SII_RS05025_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

+TS +CTPGC TGALMGC ++TA+C CHVHISK

VTSVFMCTPGCVTGALMGCNLQTATCNCHVHISK

70.6%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHV

ITS SLCTPGCKTGALM C +KTA+CGCH

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

70.6%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITSYSLCTPGCKTG LM C +KTA+C C + +SK

ITSYSLCTPGCKTGVLMACHLKTATCNCSIIVSK

70.6%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09830_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITSYSLCTPGC TG LMGC ++A C HVH+SK

ITSYSLCTPGCITGVLMGCQFQSAGCNVHVHVSK

67.6%

NZ_CP009913.1and 1 other:

NZ_CP009913.1 Lanthipeptides: SSAL8618_RS00810_lanthipeptide

Lanthipeptides: SSAL8618_RS00815_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITSYSLCTPGC TG LMGC +++ C HVH+SK

ITSYSLCTPGCITGVLMGCHIQSIGCNVHVHVSK

65.7%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGC TG LMGC +KT +C C V I K

ITSKSLCTPGCVTGVLMGCALKTITCNCSVGIGK

65.7%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHI

ITS SLCTPGC TG LMGC KTA+C C VH+

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVHV

MIBiG 4.0 matches for FYK98_RS07445

79.4%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTA+C C +H+SK

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

14.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

TASCGC

TAS GC

TASWGC

Lanthipeptide(s) for FYK98_RS07455

FYK98_RS07445

Leader:

MSVNDFKLDLVKVSKESTNSNYSVK

Core:

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

Core with dehydrations:

IDhbDhaYDhaLCysDhbPGCysKDhbGALMGCysDhbMKDhbADhaCysGCysHVHIDhaK

antiSMASH-DB 4.0 matches for FYK98_RS07445

100.0%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

91.2%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTASCGCHVH+SK

ITSVSLCTPGCKTGALMGCNMKTASCGCHVHVSK

79.4%

NC_013656.1and 18 others:

Lanthipeptides: LLKF_RS13210_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTA+C C +H+SK

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

with 127 more sequence matches

Only the first 10 are displayed here.

79.4%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTA+C C +H+SK

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

76.5%

NZ_JAQDYA010000007.1and 1 other:

NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide

Lanthipeptides: PGT72_RS09560_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTA+C C +H+S+

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

73.5%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09825_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITSYSLCTPGC TG LMGC ++A C HVHISK

ITSYSLCTPGCITGRLMGCQFQSAGCNVHVHISK

70.6%

NC_022237.1and 1 other:

NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide

Lanthipeptides: SII_RS05025_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

+TS +CTPGC TGALMGC ++TA+C CHVHISK

VTSVFMCTPGCVTGALMGCNLQTATCNCHVHISK

70.6%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHV

ITS SLCTPGCKTGALM C +KTA+CGCH

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

70.6%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITSYSLCTPGCKTG LM C +KTA+C C + +SK

ITSYSLCTPGCKTGVLMACHLKTATCNCSIIVSK

70.6%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09830_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITSYSLCTPGC TG LMGC ++A C HVH+SK

ITSYSLCTPGCITGVLMGCQFQSAGCNVHVHVSK

67.6%

NZ_CP009913.1and 1 other:

NZ_CP009913.1 Lanthipeptides: SSAL8618_RS00810_lanthipeptide

Lanthipeptides: SSAL8618_RS00815_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITSYSLCTPGC TG LMGC +++ C HVH+SK

ITSYSLCTPGCITGVLMGCHIQSIGCNVHVHVSK

65.7%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGC TG LMGC +KT +C C V I K

ITSKSLCTPGCVTGVLMGCALKTITCNCSVGIGK

65.7%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHI

ITS SLCTPGC TG LMGC KTA+C C VH+

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVHV

MIBiG 4.0 matches for FYK98_RS07445

79.4%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

ITS SLCTPGCKTGALMGC MKTA+C C +H+SK

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

14.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

TASCGC

TAS GC

TASWGC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 23.06 out of 26.12

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.51 out of 27.55

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.86 out of 18.16

Confidence: strong

Additional weak hits (6):

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.18 out of 23.43

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.20 out of 19.52

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.38 out of 39.62

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.04 out of 20.47

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

FYK98_RS07445 - Class I

Cleavage pHMM score: 12.40

RODEO score: 26

Monoisotopic mass: 3326.6 Da

Molecular weight: 3329.0 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3347.0 Da N = 1; 3365.0 Da N = 2; 3383.0 Da N = 3; 3401.1 Da N = 4

FYK98_RS07445 - Class I

Cleavage pHMM score: 12.40

RODEO score: 26

Monoisotopic mass: 3326.6 Da

Molecular weight: 3329.0 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3347.0 Da N = 1; 3365.0 Da N = 2; 3383.0 Da N = 3; 3401.1 Da N = 4

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 141 - 226; Score: 38.9

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
GnfM	Regulator of nitrogen-fixation genes
LuxO	Repressor of luminescence