LOCUS       NZ_VSTZ01000009        25967 bp    DNA     linear   CON 06-APR-2024
DEFINITION  Ligilactobacillus salivarius strain FYNLJ23_2.scaf Scaffold9, whole
            genome shotgun sequence.
ACCESSION   NZ_VSTZ01000009
VERSION     NZ_VSTZ01000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Ligilactobacillus salivarius
  ORGANISM  Ligilactobacillus salivarius
            Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
            Ligilactobacillus.
REFERENCE   1  (bases 1 to 72177)
  AUTHORS   Zhai,Q., Shen,X., Cen,S., Zhang,C., Tian,F., Zhao,J., Zhang,H.,
            Xue,Y. and Chen,W.
  TITLE     Screening of Lactobacillus salivarius strains from the feces of
            Chinese populations and the evaluation of their effects against
            intestinal inflammation in mice
  JOURNAL   Food Funct 11 (1), 221-235 (2020)
   PUBMED   31915776
REFERENCE   2  (bases 1 to 72177)
  AUTHORS   Zhai,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-AUG-2019) School of Food Science and Technology,
            Jiangnan University, Jiangnan University, No. 1800 Lihu Ave., Wuxi,
            Jiangsu 214000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 20x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009865985.1-RS_2024_04_06
            Annotation Date                   :: 04/06/2024 04:23:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,988
            CDSs (total)                      :: 1,921
            Genes (coding)                    :: 1,873
            CDSs (with protein)               :: 1,873
            Genes (RNA)                       :: 67
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 14 of 48
            Pseudo Genes (incomplete)         :: 30 of 48
            Pseudo Genes (internal stop)      :: 14 of 48
            Pseudo Genes (multiple problems)  :: 10 of 48
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:33:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7022
            Orig. end                         :: 32989
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VSTZ01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25967
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25967
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25967
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15967](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15967
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(88..99)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    915..928
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.72"
                     /tool="antismash"
     misc_feature    1165..1177
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: medium, score: 23.06"
                     /tool="antismash"
     gene            1470..2369
                     /locus_tag="FYK98_RS07405"
                     /old_locus_tag="FYK98_07515"
     CDS             1470..2369
                     /GO_function="GO:0018580 - nitronate monooxygenase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014573625.1"
                     /locus_tag="FYK98_RS07405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07515"
                     /product="nitronate monooxygenase"
                     /protein_id="WP_117641659.1"
                     /transl_table=11
                     /translation="MNRITEMLGIKYPIIQGAMQDVAKAGLVAAVSNAGGLGVLASGQD
                     TPEQVREEIHKVKELTDKPFAVNLMFLNKRAPEIVDVVIEEGVKIVTTGAGTPKLYMPK
                     LKEAGIKVMPVIPNVKIAKKMEDLGVDAVIAEGMESGGHIGTMASQTLWPQVVDAVNIP
                     VIAAGGIADNRGVKAAMAMGAEGVQCGTIFSISKESPVGDNWKKTIIESKDTSIGVIGT
                     KMGVASRTVVNKKAKELYGLEDKMTDKLKFNQLLDEAYRKAVYQDDVEDGIIFAGSVAG
                     MIHESKSVAEIISDLMKE"
     gene            complement(2445..3647)
                     /locus_tag="FYK98_RS07410"
                     /old_locus_tag="FYK98_07520"
     CDS             complement(2445..3647)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002392463.1"
                     /locus_tag="FYK98_RS07410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07520"
                     /product="MFS transporter"
                     /protein_id="WP_160988077.1"
                     /transl_table=11
                     /translation="MNKISPRLTLFALAINAFAIGSTEFISVGLLPMIVKSFNISLSQA
                     GLTVSLYALGVTIGAPLLTILTGKWSRHPLMLGIMTLFIIGNLLAAFAPFFAILLLGRI
                     LAALAHGIFMSISTVIAADVVEPSRRASAIAIMFTGLTVATVTGVPLGTFIGQQTSWNM
                     SFIFIATVGLIGLIADYFLIPKSLPIPGKVDLHGFIRIFTNKPLVLSFLITAFGYGGTF
                     AAYTYLFPLLEGVGFSANAIVIILVIYGVMVAIGNTLGGRFANTNPLNSLIKMFELLMT
                     TLLFLFVAVLANNGILTLLASILLGLFAFMSVPGLQLYVVQLAEKYVPNDITLASALNI
                     AAFNIGITLGSFIGSSVTDTLSVIYTPLFGAIVVIIAIVLILFIRNDRQSISDVIPEEN
                     K"
     misc_feature    3859..3875
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.51"
                     /tool="antismash"
     gene            complement(3923..4360)
                     /gene="tnpA"
                     /locus_tag="FYK98_RS07415"
                     /old_locus_tag="FYK98_07525"
     CDS             complement(3923..4360)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tnpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013439540.1"
                     /locus_tag="FYK98_RS07415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07525"
                     /product="IS200/IS605 family transposase"
                     /protein_id="WP_080951857.1"
                     /transl_table=11
                     /translation="MIIHEEGYVYNFNFYLVFVTKYRRKIFDTQEKVDTMKAILQRQAT
                     ISEVTVSQLEVMPDHVHMLISFKPKYAPSNIVKNLKGASARIWFKQYPETKKLLWGGHL
                     WSPSYYMGTLGDMSKEVVERYIESQYTEAMRRQLKGYYGKK"
     gene            4426..5199
                     /locus_tag="FYK98_RS10145"
     CDS             4426..5199
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FYK98_RS10145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_225415720.1"
                     /transl_table=11
                     /translation="MVKKKSNKFGYTRQYHISLSYQQIELYEKAIKTQNELYQFALKYL
                     YKTYGRKHIGRPLPFGQGINYLNNKIKAMFIKEKYDLKRWNAKKLGLSSHAADEFLKTI
                     FTNFSQYRKRLKQAGQMSDVEKYNLRMNITKDKNGKHKNPKHRSWYRKGSMNFLRNNKT
                     FRTITSQKLPNGNTKLVSPHHLNVADFGEIIVFENLKNINFEEIALTKIKRLPDNTFRL
                     QITFTREKKRISQNKVVGADWNMLTMKYLELLKIK"
     gene            5151..5822
                     /locus_tag="FYK98_RS10150"
     CDS             5151..5822
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1192: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FYK98_RS10150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="transposase"
                     /protein_id="WP_225415721.1"
                     /transl_table=11
                     /translation="MEHVNNEVFRTSENKIIAIPKDIVKKANDLEAEKDKFKSLRDSEY
                     NKRGKTALWQKYQRKQAKLSAKRANILTEKYRELAHKLVDDFDTIIIEKIDAFEMRKRS
                     LSMNKAQNTGKNKRLALIKPYELSKIVESLVNKQNKTLIKVDPYKTSQVEYGTEYEEKH
                     ELRETNKDGKRIYVSAYTGKEVDRDYNAALNIKEWGLHPEKHIKLRDYPKLKASNLVEI
                     I"
     misc_feature    5887..5900
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.18"
                     /tool="antismash"
     gene            6078..6458
                     /locus_tag="FYK98_RS07425"
                     /old_locus_tag="FYK98_07535"
     CDS             6078..6458
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003702993.1"
                     /locus_tag="FYK98_RS07425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07535"
                     /product="PTS glucitol/sorbitol transporter subunit IIA"
                     /protein_id="WP_117641661.1"
                     /transl_table=11
                     /translation="MFLQKKKTKLYETEVIEIGEEAKNFKEIKMVILFGEGAPDALRPS
                     CYIIKVNELSGEIKVGMTLQIDDEKYKITAVGNEVQTNLKNLGHIAINFTGDKTATLPG
                     SMYVEEKEYPEINEGTKIAIIK"
     gene            6525..7204
                     /locus_tag="FYK98_RS07430"
                     /old_locus_tag="FYK98_07540"
                     /pseudo=""
     CDS             6525..7204
                     /GO_function="GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003699446.1"
                     /locus_tag="FYK98_RS07430"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07540"
                     /product="fructose-6-phosphate aldolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEFLLDTVDLKKIKYYCDKLNVKGVTSNPTILKKDGVGDDLFAHL
                     KK"
     gene            complement(7265..8260)
                     /locus_tag="FYK98_RS07435"
                     /old_locus_tag="FYK98_07545"
     CDS             complement(7265..8260)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003699447.1"
                     /locus_tag="FYK98_RS07435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07545"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_160993031.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.1e-53, bitscore:
                     173.5, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSIKMFGVRDEERPMAENWAKEHNVKIDMTSDILTSDTIDEVKG
                     FDGLTLMQVAEVTDDLYPKLKEFGIKQIAQRSAGYDMYNLDAAKENGIIITNVPSYSPE
                     SIAEYTVATALNLVRKFPLIEKRVKEHNFSWEPEIRGRVIGDMTVAVIGTGRIGYHVAK
                     IFHGFGAKVVGYDLYPSDKLDGILEYRDSVEDAIRDADIISLHMPAFKENHHMFNYEMF
                     KKFKSDAVLVNMARGALIDTEDLLKALDDGLLAGAGLDVYEHEGPLVPIDLTGKDIEDE
                     TFKKVLESDKIIYSPHVAYYTDEAVRNLVEGGLNATLEVLETGDASTRVN"
     misc_feature    8454..8463
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 14.86"
                     /tool="antismash"
     gene            8467..9516
                     /locus_tag="FYK98_RS07440"
                     /old_locus_tag="FYK98_07550"
     CDS             8467..9516
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016853127.1"
                     /locus_tag="FYK98_RS07440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07550"
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="WP_117641663.1"
                     /transl_table=11
                     /translation="METTKITPKVFIDRVLGGTAIGIIVGLIPNAVLAAILKMFGTNPF
                     AVHLGQAAIIFQLGTPLIIGTLIAQKFGFDGMKMTVVGGAAFVGSGVIKYFPALNKTGA
                     YVGAGTGDIINTMLTAAIAVGLILLIGDKFGSVAIVLTPIVVGTGAGLIGFYMYPYVTA
                     ITSAIGNVINTFTELQPVLMCILIACSFAVLIISPISTVAIAMAIQVNGLAAGAAAMGV
                     AATTLVLVVNSWKVNKPGVTIAIALGAMKMMMPNLFRRPIILVPCFFTAIISAVPVALM
                     SISGSPASGGFGLVGLVGPLASIEKGLDVVAALLAWLVIPVIASLVGQFLFEKVFKLYD
                     RKDVFEFLG"
     gene            9742..9921
                     /locus_tag="FYK98_RS07445"
                     /old_locus_tag="FYK98_07555"
     CDS             9742..9921
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570405.1"
                     /locus_tag="FYK98_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07555"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_081539212.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.7e-16, bitscore:
                     52.3, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 5e-07, bitscore: 21.4,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVNDFKLDLVKVSKESTNSNYSVKITSYSLCTPGCKTGALMGCT
                     MKTASCGCHVHISK"
     CDS_motif       9742..9816
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSVNDFKLDLVKVSKESTNSNYSVK"
                     /locus_tag="FYK98_RS07445_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9817..9921
                     /prepeptide="core"
                     /locus_tag="FYK98_RS07445_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="12.40"
                     /molecular_weight="3329.0"
                     /monoisotopic_mass="3326.6"
                     /core_sequence="ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSVNDFKLDLVKVSKESTNSNYSVK"
                     /leader_location="[9741:9816](+)"
                     /alternative_weights="3347.0"
                     /alternative_weights="3365.0"
                     /alternative_weights="3383.0"
                     /alternative_weights="3401.1"
     gene            10001..11896
                     /locus_tag="FYK98_RS07450"
                     /old_locus_tag="FYK98_07560"
     CDS             10001..11896
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="FYK98_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07560"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_161011541.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.8e-83, bitscore:
                     272.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.1e-12,
                     bitscore: 38.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFNVSDVMIRNTIQTYEKSQNFNNYKEFIEIIKNDNIFLEQIL
                     LANPKLYGMLKKYNAGKLKKKKEKNFFESIYKYYKRSYYRATPFGLFSETSNGKFTVKG
                     DKKELGKTHKVVFIDIKWLTDVIFKLEKDYQSNLSFISNNGNYISGNRVMQLYSINDQD
                     LEEVSINNSKVYRIISEECSQTYKTYSEIIEKVITIYGNEYLNLTKEYINDLVENHYLI
                     SNLQENILINFSMSDFIMKVREIDVSKKYVEILTKIQELIEEYTHIEIGSGSDKLIEIY
                     HQMARLNKSDNYIQVDLYNDGNIYIDNSNKQRIEKFSNFITNTVKSVTRTYFDDYKDKF
                     IEKYGIDQDVQLIELFDPIKGIGAPYDYTHPQNEVFELEPPTSYYSHDEKEMYINKYIE
                     ALLNREEINLKCFSNYYRNLNSKESTSIQGIELFFHMVQINKKKTLALSNIIGSNNIGG
                     SSGRFSLLSDKLRDYHMKTLKQVKAANIEEGVTSCEIVFLPENIRHANIMRTSFVREKV
                     LPIFSSTDQSEVRLTNIYIGLDENENFYAYDVSTQEKMKFYVTSMYNKTLFSNELRFLC
                     EISINNNFGYVPWDLIYKDMNFIPRIMFEDIVVSPKTWRIFKFELSNIAIESIIK"
     aSDomain        10424..10678
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FYK98_RS07450_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.60E-12"
                     /identifier="RREFam001.1"
                     /label="FYK98_RS07450"
                     /locus_tag="FYK98_RS07450"
                     /protein_end="226"
                     /protein_start="141"
                     /score="38.9"
                     /tool="antismash"
                     /translation="SNNGNYISGNRVMQLYSINDQDLEEVSINNSKVYRIISEECSQTY
                     KTYSEIIEKVITIYGNEYLNLTKEYINDLVENHYLISNLQ"
     gene            11984..12961
                     /locus_tag="FYK98_RS07455"
                     /old_locus_tag="FYK98_07565"
     CDS             11984..12961
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="FYK98_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07565"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_161011542.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-25, bitscore:
                     83.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIKRNIEKNGHAIIQEYFNNKDMIYKDSEGKISEIVVPVINSK
                     FDVKKVNKEKQQRISKHVREKLPFNDWLYLKVYMSTRRQEEFIRVYIPLIQKKVEKLDG
                     KLFFLRYMDPVPQIRIRISGNNLYKIYEVIKKDLEQGHRNGILSTFDISTYDREIERYG
                     GVNAIDIAENIFCEDSKLVIKYLKFIKEKNMEDKLDDIAVAMIYFYLKIFYKTNEDILC
                     FLDKVCPNKVDKNVRSKIQYYKSVVFNQLTDIYEIDKYNFNRLKEEIKKLKLIIDKKNA
                     DTIMDSIIHVHNNRLFGINRVREQNLYFIVKKMIMSEKYILKGK"
     gene            12964..14781
                     /locus_tag="FYK98_RS07460"
                     /old_locus_tag="FYK98_07570"
     CDS             12964..14781
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015425980.1"
                     /locus_tag="FYK98_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07570"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_160987966.1"
                     /transl_table=11
                     /translation="MDEIKKLTSKNFFKTLLTLPDTIKLIFQLERKYATYLMCLNIVTA
                     LIPLLNLIVYQNLINSIFSRGMQLVYNIIYFLILQIFTVILSQLENYINGKFNMWLSYN
                     INLKLIKKTTSLKLTDYEQSDMYNLIEKITQDSTYKPFQLFNAVIAMLAAFISLLTSLI
                     FVAAWNIWIGLLLLVTPMLSLIIFLKVGQLEFLIQWKRASAERKSWYIVYLLTHDFSFK
                     EIKLNNLSDYFVEEYKKLKKDFILQDLLIARKKAYFNLGLQILLDFINIFVICTIIVSV
                     QAGRILIGNLVSLMQATTKINGYSQTIIQNIYIIYNTSLFMEQLLNFLKIENQSDYREN
                     IGIGDENRIKRIDLIDVEYKYPNSSVNALEKINFSMHTGELIAIIGENGSGKSTLVKLI
                     SELYTPSKGHIYYNGIEDKHIPTDFYQKNISILFQDFVKYELTLRENIGLGNIAEKWDD
                     NKIIHIMDKLRLNFLKENGEYNLNLQLGTWFQNGRQLSGGQWQKIALARAFFKNASVYI
                     LDEPSAALDPISEKEIFDYFVNLSKDNISIFISHDLNVARKASKIIVMNKGRVVGIGTH
                     EELLKDCSFYQELYWAEKYGRNKKKNFKK"
     gene            14747..15967
                     /locus_tag="FYK98_RS07465"
                     /old_locus_tag="FYK98_07575"
     CDS             14747..15967
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570408.1"
                     /locus_tag="FYK98_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07575"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_160987967.1"
                     /sec_met_domain="LANC_like (E-value: 3.7e-58, bitscore:
                     189.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKRKILKNKFGRVILEWDRRIEQSAYRYNFEEFTLSSGLPGV
                     ILLLLEMEDLDRTYKSKIDQYCDYLYGKLSKYGLLTGSLYSGAAGIALSLLPLKKDLRF
                     QNLIASLNDYISYYVDKEIGEFNIENVTPPNYDVIEGLSGILMYLLLIDNIDIKLVTKI
                     IIFLLTLLDDNDSLIAMYIKTGNQMSEAENEIYPNGCLNTGMSHGLAGVGSVLAYAYKK
                     GFMKKEILHGLERIIQIYEKFELVDKNKFHWKDGIDYNELVNNRTILKDNDLFIRDAWC
                     YGSPGISVLYLYIGLIQDNSYLIKKAIEILYRATKEMRNVDSNMICHGKSGIVSICILF
                     RKLTKTRKFDTFINNYTDEIESIFDKDIQNLGFLEGTTGIILTLNECFSNKGKTQWMKS
                     LMLFDDF"
     gene            16004..16693
                     /locus_tag="FYK98_RS07470"
                     /old_locus_tag="FYK98_07580"
     CDS             16004..16693
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276750.1"
                     /locus_tag="FYK98_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07580"
                     /product="response regulator transcription factor"
                     /protein_id="WP_160987968.1"
                     /transl_table=11
                     /translation="MYRILVIDDDVEILKLMKTALEMKNYEVVTCQNVHVPLKLSDFEG
                     FNLILLDIMMSKISGTEICYQIRSKISTPIIFISAKDDEKDILYGLKIGGDDYITKPFS
                     LKQLLAKIDANIKREERSRQAVQDFAEVKRDMGKITFYLEERRVCVNSQDIPLTSREYD
                     ILELLSRRASHIYSREDIYNNVYDEYAETLFGSISEYIYQIRTKFAPFKLNPVQTIRGV
                     GYKWYEE"
     gene            16683..18026
                     /locus_tag="FYK98_RS07475"
                     /old_locus_tag="FYK98_07585"
     CDS             16683..18026
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864239.1"
                     /locus_tag="FYK98_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07585"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_117641667.1"
                     /transl_table=11
                     /translation="MKNKIHSMKWRICKTAFEIFIETFLGLGLLLAITFILQKAGYISN
                     PNKVYLVLDSNKTTLTDIRQTMKKYPYDFIVFDRRTGKIVASRYQKNDKDNYYLAKVKN
                     KSYINGTTSYTISSNKLYSLVIRQNSVPEFTNPVLRKFSYNQISYIFLIIYESLIIIIA
                     IYKLIHEISKNFTAIQKIALNMGNKVTKDYPKSKIKEFDTVLKQLYQKSNELSTLIETE
                     RIEKEDLSFQVAALSHDIKTPLTVLKGNIELLELTNPDKRQLEFMESMKNSIQTLENYF
                     NTMINYTKLLNLNSISEEINLNEFIKELFLELTDIAIVNKTNNRLKVKTNLKKFHANVP
                     ALKRALINIFLNACQYADKSNPQVSVTVTEDLKFLWFEIWNNGAPFSEEAQVNAQKLFF
                     TEDKGRSGKHYGIGLSFAQAVAVRHGGTMIITNLVNDGVSVKLGIQKF"
     gene            18090..18770
                     /locus_tag="FYK98_RS07480"
                     /old_locus_tag="FYK98_07590"
     CDS             18090..18770
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897845.1"
                     /locus_tag="FYK98_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07590"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_081539208.1"
                     /transl_table=11
                     /translation="MKIEVKNISKKYQDREVLKDVSFTIEKGTICGLFGMNGVGKSTLM
                     KIIYGIEIPDKGQVLFEGHGKTSNIGALIEQPPIYSNLSAFDNLKTKALLYDIPNNQIK
                     DVLKRVGLDSTDKKHAGKFSVGMKQRLGIGMAILTQPKFIILDEPINGLDPDGVIEFLD
                     LLKSLKKQGVTILISSHQLHEIGRIVDQVIILDKGHVVYDKIQSNYKDIEEIFFNVMKG
                     ESFI"
     gene            18767..19483
                     /locus_tag="FYK98_RS07485"
                     /old_locus_tag="FYK98_07595"
     CDS             18767..19483
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FYK98_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FYK98_07595"
                     /product="hypothetical protein"
                     /protein_id="WP_081539207.1"
                     /transl_table=11
                     /translation="MIKALFSEILKLKKVRINKLLWIIPLLTGLIAFLVGGVIIFSPFA
                     IYWWESVFLYLLIGLLFLMDFNMEKKAGNFQNVKYNLWSFQIYLAKIFLIFVRVAISSL
                     FFIILVIVLNKFFSGYTELLLSKSILSIFLLLLSVFWNIPWLYFLANFINGYLLIAVNT
                     LVCLLFGSIISQTQWWFAFPYSYHYKISQYLLGVQPSGIFKIINLQLFDVMSPVLLSLL
                     ISLLLIYFTRWGKSND"
     gene            19476..20129
                     /locus_tag="FYK98_RS07490"
                     /old_locus_tag="FYK98_07600"
     CDS             19476..20129
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FYK98_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FYK98_07600"
                     /product="hypothetical protein"
                     /protein_id="WP_117641668.1"
                     /transl_table=11
                     /translation="MIRSELLKLKSSPTIYLLVSFTIFEIASTYGYLYWHRNLLTYKNI
                     VLAFALAYPSLISVITNICFEQEREANNFQEVRKYSQVKLLTIKTLILDLLLWWISFFV
                     WWIISYSIAQVKLGIISGIAMWLLIVLLNHSHMFLYMVTNKYINLVFSLVEILFIIFAS
                     NKTLMSAYWCFVAWPINYLIHADNSKLYFSAMWILILTILDYFIFRSIELERID"
     misc_feature    complement(20591..20606)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.2"
                     /tool="antismash"
     misc_feature    20672..20688
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    20853..20873
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.38"
                     /tool="antismash"
     gene            20920..21201
                     /locus_tag="FYK98_RS07495"
                     /old_locus_tag="FYK98_07610"
     CDS             20920..21201
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004564408.1"
                     /locus_tag="FYK98_RS07495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07610"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_047036161.1"
                     /transl_table=11
                     /translation="MKPMYVSINSEKTGANLKSLFKNNGYSVRDIQSVMGFENPQSIYK
                     WLSGRSLPSLDNLVILSKVLHTTIEDILVVDGDVVFLFNLTWTIQLNR"
     gene            21223..21471
                     /locus_tag="FYK98_RS07500"
                     /old_locus_tag="FYK98_07615"
     CDS             21223..21471
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013853768.1"
                     /locus_tag="FYK98_RS07500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07615"
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="WP_052757137.1"
                     /transl_table=11
                     /translation="MQEVMSYRGYKGTIEYSLEDNVLHGEVLGIRSLLSYEGNTLQELK
                     DDFEDTIDDYFECCKNHNMTPEKPYKQNIVINLEPDL"
     gene            21589..21777
                     /locus_tag="FYK98_RS07505"
                     /old_locus_tag="FYK98_07620"
     CDS             21589..21777
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FYK98_RS07505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FYK98_07620"
                     /product="hypothetical protein"
                     /protein_id="WP_081539203.1"
                     /transl_table=11
                     /translation="MKKSRVNKIKIESKKALVVRRLDWRAPSSRINYSILEMIDDLNDS
                     KLERASNLAELESLLNK"
     gene            22186..23820
                     /locus_tag="FYK98_RS07510"
                     /old_locus_tag="FYK98_07625"
     CDS             22186..23820
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003706793.1"
                     /locus_tag="FYK98_RS07510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07625"
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_014573618.1"
                     /transl_table=11
                     /translation="MKRIKAIITGIFISLTAILLVACGKSTGENSKQVLNLSTTGPLDT
                     IDISKSTGYGQTGNVFESFYRLGKDGKVTPGLAKSGQVSQDGKTWTFTLRDAKWSNGDK
                     ITAQDFVYSWKRTIDPKTASPYAYLFYDVKNAQAINEGKMSADKLGIKAEGDNKVVITL
                     DRPISYFKVLMTYPLFGPQSEKVVQKYGKKYGTNSKYMVYSGPFKVKDWNGTSDKWSFV
                     KNNQYWDKKVVKLQKINYQVVKNTNTGYQLFQQGKLDLTPLSSEQVKNLHNKPEFKQYS
                     YSYVAYLDYNFNDSNEVNRKALNNKNIRLALSLAIDRKTLTKKVFGDGSNVPTGFVASD
                     LATNPKTGKDFAAEQKVDNTVDYNEKLAREYWKKGLQEIGEKNLNFTILASNEMANNDA
                     LTQYLQSQYTKVLPGIKVSVQNIPGNSALSKARKGNYDIYVSGWGGDFKDPITFMQIPV
                     TGTSYNYGKYSNKEYDALIEKAQNEDANDANKRWEDLVKAARLFNADQGVTPLYQQTTS
                     YMQNTKVKGIIQNTAGTQWNYKYAYIK"
     gene            24083..24862
                     /gene="sufC"
                     /locus_tag="FYK98_RS07515"
                     /old_locus_tag="FYK98_07630"
     CDS             24083..24862
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sufC"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014573617.1"
                     /locus_tag="FYK98_RS07515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FYK98_07630"
                     /product="Fe-S cluster assembly ATPase SufC"
                     /protein_id="WP_081531057.1"
                     /transl_table=11
                     /translation="MSVLEVKDLHVTVEGKEILKGVNLKMSTGEIHAIMGPNGTGKSTL
                     SSTIMGDPAYKITKGDILLNGKSIIDLPVDERARMGLFLAMQYPQEIPGVTNAEFVKSA
                     INARRPKDDPIPLMDFIKRLDETLETLDMSEEMADRYLNEGFSGGEKKRNEIMQMMMIR
                     PEFAILDEIDSGLDIDALKVVSRGVNQMRGDNFGSLIITHYQRLLNYIIPDYVHVMMDG
                     RLVKTGGPDLAIRLEKEGYAKLRDELGLDIKLVDENA"
     misc_feature    25729..25743
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.04"
                     /tool="antismash"
ORIGIN
        1 gggggaagaa ttcattgtca cataatttat caacatcaga cctattaaat gttaagacag
       61 ttgctaagag acgtaacaga cctcaatggg ttcgtttacc agaaaagatc tactacgaaa
      121 agaatgctat cagctatcta caagatgaaa ctgaagatat caaccgtgca ttcatcgtag
      181 ctgacccagg aatggttaag tttggatttg tagacaaagt ttacgatcaa ttagcagcaa
      241 gagaaaatga agttaagaca gctctttatg gaactgtaag acctgaccca atgttaggac
      301 aaacaattga aattgctcaa caaatggcac aattcgaacc agatacagtt attgctattg
      361 gtggtggttc cgcattggat gctacaaaga ttgctcgtta catctatgaa tactccttag
      421 atcaagaacc aggattctta gatagctacg aaaaagttag tgaagtattt aaagaattac
      481 aacaaaaatt cgttgatatc cgtaagagaa ttgttaagtt ccatcacgct aagaagacaa
      541 gaatgtttgc aattccaaca acatctggta caggttctga agtaacacca tatgctgtta
      601 ttacagatga caatacacat gttaagtacc cattaacaga ctatgaattg acaccacaag
      661 tatcaattgt agacccagaa tttgttatga ctgttcctaa gagaactgta gcattatctg
      721 gattggatag tttatcacat gctcttgaat catatgtatc agttatggcg tctgacttca
      781 cacgtccatg gtcaatgcaa gctatcaagt tagtatttga aaacttagaa gcttcataca
      841 actacgatcc aaaacatcct acattggaag gcgaaaaggc tcgtgaaaac atgcactatg
      901 ctgcaacatt agcaggtatg gcatttgcta acgcattctt aggtatcaac cactcaatcg
      961 ctcataagac tggtggggaa tttggattac cacatggttt ggcaatttcc attgctatgc
     1021 aacatgtaat taaatttaac ggtgcttctg gtcgtgtaaa gcgtacacca ttcccacgtt
     1081 atgaagtata tcgtgctcaa aaagattatg cagatattgc tcgtgcatta ggcttgaaag
     1141 gcaactcaga tgctgaatta gtagatgcat tatgcaacaa gattaacgat ttaatgaaga
     1201 agttagacgt tgaacctaag ttatctgcaa atggtgtaac taaagaacaa tttgataaag
     1261 ctcttgataa gatggttgat cgtgtttacg atgatcaatg cacaactgca aatcctcgtc
     1321 aaccatactt ggaagaaatt cgtcaattgt tgatcgatca attctaatta tttagtaaat
     1381 tgcaattacc attaatatca attgggatat cttataacta tatggttgta agatatcctt
     1441 tttgttttaa ataattgagg tgagaattta tgaatcgaat tacagaaatg ttaggaatta
     1501 aatatccaat tattcaaggt gcgatgcaag atgtagccaa agctggatta gtagcagcag
     1561 tttctaatgc tggtggttta ggggtgctag cttcagggca agatacacct gaacaggtac
     1621 gcgaagaaat ccataaagta aaagaattaa ctgataagcc atttgctgtc aacttgatgt
     1681 ttttaaataa gagggctcca gaaatcgttg atgttgtcat tgaagaagga gtaaaaattg
     1741 taacaactgg tgctggtaca cctaaattat acatgcctaa actaaaggaa gcaggaataa
     1801 aagtaatgcc tgtaattcca aatgtaaaaa ttgctaaaaa gatggaagat ctaggtgtag
     1861 atgctgttat tgctgaaggt atggaaagtg gaggacatat cggaactatg gcatcgcaaa
     1921 ctctttggcc tcaagttgtt gatgccgtaa atattcctgt tattgcagca gggggaattg
     1981 ctgataatcg tggagtgaaa gcagcgatgg cgatgggagc tgaaggtgta caatgtggta
     2041 caattttctc gatttctaag gaaagtcccg ttggtgataa ttggaagaaa acgattattg
     2101 aatcaaagga cacttctatt ggtgtaattg gtacaaaaat gggagtagcc agtcgcacag
     2161 ttgtaaataa gaaagctaaa gaactatatg ggttagaaga caaaatgact gataagttaa
     2221 aattcaatca attattagat gaggcatatc ggaaagctgt ttatcaagat gatgtagaag
     2281 atggaataat atttgctgga tcagtcgctg gaatgattca cgagagtaag agtgttgcag
     2341 aaattatttc tgatttaatg aaagagtagt taaatccaaa taatattgaa gctaaaaaca
     2401 cgctaaggat aaaaattttt ctccttagcg tgtttttgta aagattattt attttcttca
     2461 ggaattacat cagagataga ttgacgatca tttctaatga atagaattag tacaatagcg
     2521 ataatcacga ctatggctcc aaataggggt gtgtatataa ctgataaagt atcagtcaca
     2581 ctggaaccga taaatgatcc tagtgttata ccgatattaa aagcggcaat gtttaaagct
     2641 gaagccagag taatatcatt aggtacatat ttttcagcta attgaactac atataattgc
     2701 aagcctggaa cgctcataaa ggcgaataaa ccaagtaata tacttgctag taatgttagt
     2761 atcccattat tagccaaaac tgcaacaaaa aggaaaagta aggtagtcat taacaattca
     2821 aacatcttta tcaaagaatt aagagggtta gtattagcaa aacgacctcc taaagtattg
     2881 ccaatagcga ccattactcc ataaataact aaaataatga caatggcgtt tgctgaaaat
     2941 cctactcctt ctagtaatgg aaaaagataa gtatatgctg caaaagttcc tccatagcca
     3001 aaagcagtaa tcaggaatga tagaactaaa ggtttattag taaagatacg aataaaacca
     3061 tgcaaatcta cttttccagg aattggtaaa gatttaggaa ttaaaaaata atcagcaatt
     3121 aaaccaatga gtcccacggt agcgatgaag ataaaagaca tattccaaga agtttgttga
     3181 ccaataaaag tacccaaagg aacacctgta acagttgcaa cagttagtcc ggtaaacata
     3241 attgcaatag cactagcacg acgagatggt tcaactacat cagcagctat aactgttgaa
     3301 attgacatga atattccatg agctaaagcg gctaaaattc tacccaatag taaaatagca
     3361 aaaaacggag caaaagctgc aagtaaatta cctattataa ataaagtcat gattcctagc
     3421 attaagggat gacgactcca tttaccagtt aaaatcgtta acaaaggtgc gccaatagtt
     3481 acgcctaaag catacaatga aacagttagt ccagcttgag ataaactaat attgaaactt
     3541 ttaacgatca ttggaagtaa tccaacgcta ataaattcag tagaacctat tgcaaaagca
     3601 ttaatagcca gtgcaaataa tgttaaacga ggtgaaattt tattcatctt aaaaattctt
     3661 tcctttcata tattaagttg atgaagataa tatatactat ttagttactt tttgtaagta
     3721 cgaactttaa agtaacatag gcactttttg gtaacttttg tgtaagttag agaaaatagg
     3781 aaagaaaaaa taataatatc gtattaaagg atataagatg ataaaaaata ttatttaaaa
     3841 taattaccta ctatatattg attataaaac gggcgcaaac ctctgatttt aatcaggagt
     3901 caagcctgct aaactaactt agctattttt taccatagta acctttaagt tgtcttctca
     3961 tagcttccgt atattgagat tcaatatatc tttctacaac ttctttactc atatcgccta
     4021 aagttcccat ataatagcta ggcgaccata aatgtccacc ccataataat tttttagttt
     4081 caggatattg tttgaaccat attctagctg acgctccttt aagattttta acaatattag
     4141 atggagcgta tttaggctta aaagaaatta acatatgtac atggtctggc ataacctcta
     4201 actgactaac agttacttct gaaatagttg cttgtcgttg taaaatagct ttcatagtgt
     4261 ccactttctc ttgagtgtca aatatttttc ttcggtattt agtaacgaaa actaaataaa
     4321 aattgaagtt ataaacgtac ccctcttcat gtataatcat ttacatacca ccctttcaat
     4381 gctgttataa ttataacata tatttctcga aaggatgtta catgaatggt taaaaagaag
     4441 agtaataaat ttggatatac aagacaatat catatttctt taagttatca acaaatagaa
     4501 ttgtacgaaa aagcaataaa aacacaaaat gagttatatc aatttgcatt gaagtactta
     4561 tataagacct atggtcgtaa acatattgga agaccgttgc cttttggaca aggaataaac
     4621 taccttaata ataaaattaa ggcaatgttt attaaagaaa aatacgactt aaaacgttgg
     4681 aatgctaaga aactaggatt atcttctcac gctgccgatg agtttttgaa aacaatcttt
     4741 actaattttt ctcaatatcg taagagatta aaacaagcag ggcaaatgtc agatgttgaa
     4801 aaatataatc tcagaatgaa tattactaaa gataaaaatg ggaaacacaa aaatcctaaa
     4861 catcgttcat ggtatcgtaa aggttcaatg aattttctac ggaataataa aacatttagg
     4921 acaattactt cacaaaaatt acctaatggc aatacaaaat tggtttcgcc acaccattta
     4981 aatgtagccg attttggaga aataatagta tttgagaatt taaagaatat taattttgaa
     5041 gagatagctt taactaagat taaaagatta ccagataaca catttagact acaaataact
     5101 tttactcgtg aaaaaaaacg tatttctcaa aataaagttg ttggcgcaga ttggaacatg
     5161 ttaacaatga agtatttaga acttctgaaa ataaaataat agcaatacct aaggacattg
     5221 tgaaaaaagc taatgactta gaagcagaaa aagataaatt caaatcttta agagatagtg
     5281 aatacaacaa gcgtggtaaa actgctttat ggcaaaaata tcaacgtaaa caagcaaaat
     5341 taagtgctaa aagagctaat attttaactg aaaaatatag agaattagca cataaattag
     5401 tcgatgactt cgatactatc atcattgaaa aaatagatgc ttttgagatg agaaaacgta
     5461 gtttgtcaat gaataaagca caaaatacag gtaagaataa gcgattagct ttaatcaaac
     5521 cttatgaatt atcaaagatt gtagagtcgt tagtaaacaa gcaaaataaa actcttatta
     5581 aagtagaccc ttataaaact agccaagtag aatatgggac tgaatatgaa gaaaagcacg
     5641 agttaagaga gactaataaa gatggtaaac gcatatatgt ttcagcatat actggtaaag
     5701 aagtagatag agattataac gcagccttaa acattaagga atggggatta cacccagaaa
     5761 aacatataaa attaagagat tatcctaaat taaaagcaag taacttggtg gaaataattt
     5821 aaaaaaacga agttttttag gaaacggaaa cgaatcctac cgaactaata gcacaaaatt
     5881 atgcgtatca ccctgagcga gtcaaaatgg gtgcgatgat tagtgaatat tatatattta
     5941 gtataagtgg cggtatttcc agtcattata actaggttcg gagcgtgtat cgctttttaa
     6001 tgtacacgta atgtaatcgc gtgacacgat tcctgcgatt ttaatcgcgg gtagttcaag
     6061 atgaggtgtg atttgttatg ttcttacaaa agaaaaagac taaactttac gaaacagaag
     6121 ttatagaaat tggtgaagaa gctaagaatt tcaaggaaat taagatggtt atcttatttg
     6181 gcgaaggtgc tccagatgcg cttagaccat cttgctacat cattaaagtg aacgaattat
     6241 ctggcgaaat aaaggtaggc atgactttac aaattgatga tgaaaaatat aaaataacag
     6301 cagtaggtaa cgaagttcaa actaacttga agaacttagg tcatatagct attaacttca
     6361 caggggataa aactgctaca ttaccaggat caatgtatgt agaagaaaag gaatatcctg
     6421 aaattaatga aggtacaaaa attgctatta taaaataaat tagggaagca tagggagcgt
     6481 tgaggtttct ctatgctttt ctagcatgaa aggacaaaat agatatggaa tttttattag
     6541 atacagttga tttgaaaaag attaaatatt actgcgataa attaaatgtt aaaggagtaa
     6601 cttctaatcc aacgattcta aaaaaagatg gagtaggcga tgatttattc gcacatctta
     6661 aaaaataaag gaaattattg gagatgaaag agaactccac gtacaagttg tagcaccttc
     6721 tgtatctgga atgatagatg aagctcacaa aattgtagat gaagtaggca aggatgtata
     6781 tatcaaagtt ccaactactt tagatgggtt agaagtcatg aaaaagctaa aggctgaagg
     6841 aattagagta acagcaactg caatttatac cgaatttcaa ggctatcaag caattaacgt
     6901 tggtgctgac tatttggctc cttactataa tagaatgtta aatcaaaata ttgattcagc
     6961 tgaggttatt agaaatctag ctaaaagaat taacttagat aatagcaata ctaaaatttt
     7021 agctgcaagt ttccataatg tagcacaagt aaatgaagct ttaagcaatg gtgctcaagc
     7081 tgtaacagtt ggtcctgata ttgtagcatc tgcttttaaa atgccatcta tttctcaagc
     7141 tgtggcagat tttagaaatg actgggaaag catatatggt gataaaaata taaataactt
     7201 ataataagta taataaaaaa cctctgagat agattctcag aggtttttat taggattaaa
     7261 ctaattagtt tacacgtgtt gaagcatcgc cagtttccaa tacttccaaa gtagcattta
     7321 agccaccttc aactaagttt ctaacagctt catcagtgta gtatgctacg tgtggtgagt
     7381 agataatctt atcagattca agtactttct tgaatgtttc gtcttcaata tcttttccag
     7441 ttaggtcgat aggaactaat ggaccttcat gttcgtaaac gtcaagacca gcaccagcta
     7501 aaagaccatc atctaaagct ttcaataaat cttctgtatc aattaaagca ccacgagcca
     7561 tgttaactaa tactgcatca gatttgaatt tcttgaacat ttcgtagtta aacatgtggt
     7621 ggttttcctt gaaagcaggc atatgtaagg aaataatgtc tgcatcgcgg attgcatctt
     7681 ctacggaatc acgatattcc aagatgccgt ctaatttgtc actaggatat aggtcatagc
     7741 cgacaacttt agcaccaaaa ccatggaaga ttttagctac atggtaacca atacggccag
     7801 ttccgataac agcaactgtc atgtcaccga taacacgacc tctgatttca ggttcccatg
     7861 agaaattatg ttccttaaca cgtttttcaa ttagtgggaa tttacgtact aagttcaatg
     7921 ctgtagctac agtatattca gcaattgatt ctggggagta gctaggcaca ttagtaataa
     7981 taatgccatt ttctttagca gcatctaaat tgtacatatc ataaccagca ctacgttgtg
     8041 cgatttgttt gataccaaat tctttcaatt taggatataa gtcatctgta acttctgcta
     8101 cttgcattaa agttagaccg tcaaaaccct taacttcatc gatagtatca gatgtaagga
     8161 tgtcactagt catatcaatt ttaacgttgt gttcttttgc ccagttttca gccattggac
     8221 gttcttcatc acgaacacca aacattttga ttgaaaccat taaaaattcc tcctcatata
     8281 aatgataacc tttacaatat atattatatc atcattataa cagaatactt aaatataagt
     8341 gttaaattta attaattttt tacgtttttt tctaataaaa gaaagaaact aaagaaaaat
     8401 atatttacat tgctcataat ctcacttata ataatgtgta tattttatat aaagaaggtg
     8461 acgaatttgg aaacaacaaa gattacaccc aaagttttca ttgatcgtgt tttaggcggt
     8521 actgccatcg ggattatagt tggcttaatt cctaatgctg ttcttgccgc tatcctcaag
     8581 atgttcggca ctaatccttt tgccgtacat ttaggacaag cagcaattat tttccaatta
     8641 ggaacacctt taattattgg tacattgatt gctcaaaagt ttggctttga tggcatgaag
     8701 atgaccgtag ttggtggagc cgcatttgta ggttctggcg taattaaata cttcccagcg
     8761 ttgaataaaa caggtgccta tgtaggtgct ggaacagggg atattattaa taccatgtta
     8821 acagcagcga ttgcagttgg attaattctg ttgataggcg ataaatttgg atcagtagca
     8881 attgttttaa caccaattgt agtaggaaca ggtgctggct taattggatt ctatatgtat
     8941 ccatatgtta cagcgataac ttccgcaatt ggtaatgtga ttaacacatt tacagaatta
     9001 caaccagttt taatgtgtat tttaattgcc tgctcttttg cagtgttaat tatctctcca
     9061 atttcaacag tagcgattgc aatggctatc caagttaacg gcttggctgc tggtgctgct
     9121 gcaatgggag ttgctgcaac aacacttgta cttgtagtaa actcatggaa agttaacaag
     9181 ccaggggtaa caattgcgat tgccttaggt gcgatgaaga tgatgatgcc taacttattt
     9241 agacgtccaa ttatcttagt accatgtttc tttacagcaa taatttctgc agttcctgta
     9301 gctttgatgt caatttcagg ttctcctgct tccggtggtt ttggtttagt aggtttagta
     9361 ggaccattag catcaattga aaaaggctta gacgttgtcg cagcattgct agcatggtta
     9421 gttattccag ttattgcgtc acttgtcggt caattcttat ttgaaaaagt atttaagtta
     9481 tatgaccgca aagatgtttt tgaattttta ggttagaaaa tattagaatt gaatctaatt
     9541 aaaaatagtt taagttaaga aaatgctgaa ggttacattg ctgaaatgtt aatctttggc
     9601 attttttatt ttaaagattt ttccatggtt ttaaaattat cagtttaaat aatatgtatt
     9661 ctgaacaaaa tctgaaaata ataacatatt atagtgacgt tctagaacaa acaattaaag
     9721 ggttattagg aggttttcta aatgagtgtt aatgatttta aattggattt agtaaaagta
     9781 tcaaaggaaa gtacaaattc aaattattca gttaaaatta caagctactc actttgtacc
     9841 ccaggttgca aaacaggtgc actaatggga tgtacaatga aaactgcatc atgtggttgt
     9901 catgtacata taagtaaata gtaagaaagt aagggatagc gtagatcaat ttgatgattt
     9961 gctatcccat ttttttaata ggtgaaaggg gcttgaaaaa atgaataatt tcaatgttag
    10021 tgatgtaatg atacgtaata caattcaaac atatgaaaaa agtcaaaatt tcaataatta
    10081 taaggaattt attgaaatta ttaaaaatga taatattttt cttgaacaaa tattattggc
    10141 taatcctaag ctgtatggaa tgcttaaaaa gtataatgca ggaaaactaa agaaaaagaa
    10201 agaaaaaaat ttttttgaat caatatataa atattataaa aggagctatt atcgagcaac
    10261 tccttttgga ctatttagtg aaacttctaa tggtaaattt accgttaagg gtgataagaa
    10321 agaattaggg aaaacacaca aagtagtttt tatagatatt aaatggttaa cagatgtaat
    10381 ttttaaatta gaaaaggact atcaatcaaa tttatctttc atatctaata atggaaatta
    10441 cattagtgga aatcgtgtta tgcaattata ttcaataaat gatcaagatt tagaggaagt
    10501 tagtattaat aactctaaag tttatcgaat tatatcagaa gagtgtagcc aaacttataa
    10561 gacatatagt gaaatcatag aaaaggttat aacaatatat ggtaatgaat acttaaattt
    10621 aacaaaagaa tatattaatg atttagtaga gaatcattat ctaatatcaa atttacaaga
    10681 aaatatacta attaattttt ctatgtcaga cttcataatg aaagttaggg aaatagatgt
    10741 tagtaaaaaa tatgtagaaa tattaacaaa gatacaagag ttaattgaag aatatacaca
    10801 tattgaaata ggttcgggtt ctgataaatt aattgaaata tatcaccaaa tggctagact
    10861 taataaaagt gataattata ttcaagtaga tttatataat gatggaaata tatatattga
    10921 taatagtaat aaacaaagaa tagagaaatt ttcaaatttt ataactaata ctgttaaatc
    10981 agtaactagg acttattttg atgactataa agataaattc attgaaaaat atggtattga
    11041 tcaagatgtg cagttaatag aactatttga tccaataaaa ggaattggcg caccgtatga
    11101 ttatacgcat cctcagaatg aagtttttga attagagcct ccaacgtcat attattccca
    11161 tgatgaaaaa gaaatgtata ttaataaata tatagaagct ttattaaata gagaggaaat
    11221 taatttgaaa tgcttttcta attattatag aaatctgaat tccaaagaaa gtacctcaat
    11281 acaaggaata gaattatttt ttcatatggt ccaaattaat aagaagaaaa ctttagcatt
    11341 aagcaatatt ataggcagta ataatatagg gggatcctct ggaaggttct cattattatc
    11401 agataaatta agggattatc acatgaagac acttaaacaa gtgaaagctg caaatattga
    11461 agaaggggtg acgtcttgtg aaatagtttt tcttcctgaa aatatacgac acgctaatat
    11521 aatgcgaaca tcttttgtaa gagaaaaagt tcttcctatt ttctcaagta ctgatcaatc
    11581 tgaagtaagg ctaactaata tttatattgg attagatgaa aatgaaaatt tttatgcgta
    11641 tgatgtgtct actcaagaaa aaatgaagtt ttatgtaaca agcatgtata acaagacatt
    11701 atttagtaat gaactaagat ttttatgtga aatttcaata aataataatt ttggatatgt
    11761 accatgggat ttaatctata aagatatgaa ttttattcca cgaattatgt ttgaggatat
    11821 agtagtcagt cctaagacat ggagaatatt taaatttgaa ttaagtaata tagcaataga
    11881 gtcgattata aagtagagaa atataccgaa tgaaatttat attgttgacg gtgataacaa
    11941 actatatatt aatcgtaaaa attcacttga tgttgaactg tttatgtcag aaataaaaag
    12001 aaatatagaa aagaatggtc atgccattat acaagaatat tttaataata aagacatgat
    12061 atataaagat agtgaaggaa aaatatcaga gatagtggtt ccagttatta atagtaaatt
    12121 cgatgttaaa aaagtaaaca aggaaaaaca acagagaatc tccaaacatg ttcgagagaa
    12181 attgccattc aatgattggt tatatctaaa agtgtatatg tcgactagga gacaagaaga
    12241 gtttatacga gtttacatac ctctgattca aaaaaaggta gaaaaattag acggaaaact
    12301 atttttctta cgttatatgg atccagtacc acaaataagg ataaggataa gtggtaataa
    12361 tttatataaa atatatgaag ttattaaaaa agatttggag caaggtcata gaaatggtat
    12421 tttatcgact tttgatattt ctacatatga tcgcgaaatt gagagatatg gaggagttaa
    12481 tgcaatagat atagctgaaa atattttctg tgaagattct aaacttgtaa taaagtattt
    12541 gaaatttata aaagaaaaga acatggaaga taaacttgat gatattgcag ttgcaatgat
    12601 ttatttttat ttaaaaatat tttataaaac aaatgaagac attttatgtt ttctagataa
    12661 agtctgtccc aataaggtag ataaaaatgt aaggtctaaa atacaatact ataaaagtgt
    12721 agtatttaat cagttaactg acatatatga gattgacaaa tacaacttta atagacttaa
    12781 ggaagagatt aaaaaactaa aattaataat tgataaaaaa aatgctgaca ctattatgga
    12841 tagtattata catgtacata ataataggtt atttggaatt aatagggtta gggaacaaaa
    12901 tctgtatttt attgtaaaaa aaatgattat gtctgaaaaa tatattttga aagggaaata
    12961 atgatggatg aaataaaaaa actaacatca aaaaattttt ttaagacatt attaacactt
    13021 ccagatacga ttaagttaat ttttcaatta gaaagaaaat atgcaacata cttaatgtgc
    13081 ttaaatatag taacggcatt aattccgcta ttaaatttaa tagtttatca aaatctgatc
    13141 aatagtatat ttagtcgagg aatgcagctt gtatataata ttatttattt tttaatacta
    13201 caaatattta cggtaatatt atctcaatta gaaaattata taaacggaaa atttaatatg
    13261 tggctttctt acaatattaa tttaaaattg ataaaaaaaa caacctcctt aaagttgaca
    13321 gattatgaac aatcagatat gtataatctt attgagaaaa taacacagga tagtacgtat
    13381 aaaccatttc aactttttaa tgctgttatt gctatgctgg ctgcttttat atctttactg
    13441 actagtttga tttttgttgc ggcgtggaac atatggatag gattgctgtt attagtaact
    13501 cctatgttat ctttaattat atttttaaaa gtaggtcaac ttgaattttt aatacaatgg
    13561 aaaagagcga gtgcagaaag aaagtcgtgg tatatagttt atttattgac acatgacttt
    13621 tcttttaagg aaattaaatt aaataattta agtgattatt ttgtggaaga gtataagaaa
    13681 ttaaaaaaag attttatatt acaagatttg cttattgcta gaaagaaagc atattttaat
    13741 ttgggacttc aaattttatt agactttatc aatatttttg ttatatgcac tattatagta
    13801 tctgtacaag ctggaagaat attaatagga aatttagtta gtcttatgca agcaactaca
    13861 aagataaatg gctattcaca aacaatcata caaaatattt atattattta taatactagt
    13921 ttgtttatgg agcaattact taattttttg aaaatagaaa atcaaagtga ttatcgtgaa
    13981 aacataggga taggtgatga gaacagaata aaaaggatag atctaataga tgttgaatat
    14041 aagtatccta actcttctgt caatgcttta gaaaaaataa acttttctat gcatacaggg
    14101 gaactaattg cgataatagg ggaaaatgga tctggtaaaa gtactctagt aaagttaatc
    14161 tcagagttat acacaccatc taaaggtcat atatattata acggtattga agataagcat
    14221 ataccgacag atttttatca aaagaatata tcgatattat tccaagattt tgttaaatat
    14281 gagctaactt taagggaaaa tattggtctt ggtaatattg cagagaagtg ggatgataat
    14341 aagattatac atattatgga taaattaagg ttaaattttt taaaagagaa tggagaatat
    14401 aatttaaatt tacaattagg aacttggttc caaaatggga ggcaattatc aggtggtcag
    14461 tggcaaaaaa tagctttggc tagagctttt tttaaaaatg cttctgtata tatattagat
    14521 gaaccaagtg cagcgctaga tccaatttca gaaaaagaaa tatttgatta ttttgtaaat
    14581 ctatccaaag ataatatatc tatttttatc tcacatgatt taaatgtagc tcgtaaggca
    14641 tcaaaaataa ttgttatgaa taaaggaaga gtagtaggta ttggaactca tgaagaactt
    14701 ttaaaagatt gtagtttcta tcaagaacta tattgggcag aaaaatatgg aagaaataaa
    14761 aagaaaaatt ttaaaaaata aatttggcag agtgatatta gaatgggaca ggagaattga
    14821 acagagtgct tatcgataca atttcgaaga attcacgctt tcttcgggat taccaggggt
    14881 tattttactg ttattagaga tggaagattt agataggaca tataagtcca aaattgatca
    14941 gtattgtgac tatttatatg gaaagttatc aaaatatgga cttttaacag gttctctata
    15001 ttcaggtgca gctgggattg cattaagttt attaccactc aaaaaagatt tgagatttca
    15061 aaatttaatt gcaagtctaa atgattacat tagttattat gtagacaaag aaattggaga
    15121 gtttaatatt gaaaatgtta ctccacctaa ttatgatgtg attgaaggat tatcaggaat
    15181 tctcatgtat ctgcttttaa tagataatat agatatcaaa ttagtgacaa aaattattat
    15241 ttttttatta accttattag atgataatga ttcattgata gcgatgtata ttaaaacagg
    15301 taaccaaatg tcagaggcag aaaacgaaat ttatcctaat ggttgtctaa atacaggtat
    15361 gtcacatgga cttgctggtg taggaagtgt attggcttat gcgtataaaa agggctttat
    15421 gaaaaaggaa atattacacg gattagaaag gattattcag atttatgaaa aatttgaatt
    15481 agttgataag aataaatttc attggaaaga tggaatagat tataatgaat tggttaataa
    15541 tagaacaatt ttaaaagata atgatttatt tataagagac gcatggtgtt acggtagtcc
    15601 aggaataagt gttttatatt tatatattgg actaattcaa gataattcat accttataaa
    15661 aaaagcaata gaaatactat atagagctac taaggaaatg cggaatgtag attccaacat
    15721 gatttgtcat ggtaagtcag ggatagtttc gatatgcatt ttatttagga aacttacaaa
    15781 aacgagaaaa tttgatacat ttataaataa ctatactgat gaaatagaaa gtatttttga
    15841 caaagatatt caaaatttag gctttcttga gggaacaacg ggtattattt tgactttaaa
    15901 tgagtgtttt tcaaataaag ggaaaacgca atggatgaaa tcattaatgt tatttgatga
    15961 tttttaactg tagttataaa aattattata aggaagagga cgtatgtata gaatcttagt
    16021 tatagatgat gatgtagaaa ttttaaaact tatgaaaaca gcattagaaa tgaaaaatta
    16081 tgaggttgta acttgccaaa atgttcatgt tccgttaaaa ttatcagatt ttgagggttt
    16141 taatttaatt ttattagata ttatgatgtc aaagatatca ggaactgaaa tttgttatca
    16201 gattcgttct aagatttcaa cgccaattat ttttataagt gctaaagatg atgaaaaaga
    16261 tattttatat ggtttaaaaa ttggtggtga tgattatata accaaacctt ttagtttgaa
    16321 acagttatta gctaaaattg atgcaaatat taaacgagaa gaacgtagtc gtcaagcagt
    16381 tcaggatttc gcagaagtta agcgtgatat ggggaaaata actttttatt tggaagaacg
    16441 aagggtatgc gttaatagtc aagatattcc tttgactagt cgtgaatatg atattttaga
    16501 attgctctca cgaagggctt ctcatattta tagtcgtgaa gacatttata ataatgtata
    16561 tgacgaatat gcagaaactt tatttggatc tatttccgaa tatatatatc aaatccgaac
    16621 aaagtttgca ccatttaagt taaatcctgt tcaaacaatt cgtggtgtgg ggtataagtg
    16681 gtatgaagaa taaaatacat tctatgaagt ggcgaatatg taaaacagct tttgagattt
    16741 ttattgaaac ttttttaggt ttaggtttgt tattagcaat aacttttatc ttgcagaagg
    16801 caggatatat atcaaatccg aataaagttt atttagtatt agattctaat aaaactactt
    16861 tgacggatat tagacaaacg atgaaaaaat atccttatga ctttattgta ttcgatagga
    16921 gaacaggaaa aattgtagca agtagatatc aaaaaaatga taaagataat tactacttag
    16981 ctaaagtaaa gaataaaagt tatataaatg ggactacaag ttatactata tcttctaata
    17041 agttatatag cttagtgatt agacaaaata gtgttccgga atttactaat ccagtcttga
    17101 gaaagttttc gtataatcaa atatcatata tatttttgat tatatacgaa tcattaataa
    17161 tcattattgc aatttataaa ctaattcatg agatttcaaa aaattttaca gctattcaaa
    17221 agattgcttt aaatatgggg aataaggtta ctaaagatta tcctaagtcg aaaattaaag
    17281 aatttgatac tgtattaaag caactctatc aaaaaagtaa tgagttatca actttaattg
    17341 agactgaacg gatagaaaaa gaagatttat catttcaggt agcagcatta tctcatgata
    17401 taaaaacacc acttactgta ttaaaaggaa atatagagtt gttggaactg actaatcctg
    17461 ataagagaca attagaattt atggaatcta tgaaaaacag tattcaaact ttagaaaatt
    17521 attttaatac aatgattaat tatactaagt tactaaattt aaattcaata agcgaagaaa
    17581 taaatttaaa tgaatttatt aaagaacttt ttcttgaact aacagatatt gccatagtca
    17641 acaaaacgaa taatcgatta aaggtaaaaa ctaatttaaa gaaatttcat gctaatgttc
    17701 cagctctaaa acgagcacta atcaacattt ttcttaatgc gtgtcagtat gcggataaaa
    17761 gtaatcccca agtatcggtt actgtaactg aagatttaaa atttttatgg tttgaaatat
    17821 ggaataatgg ggcaccattt tcagaagaag cacaagttaa tgcgcaaaag ttatttttta
    17881 ctgaagataa aggccgtagt ggaaagcatt atggaattgg actatctttt gcacaagcgg
    17941 ttgcagtcag acatggtggt accatgataa ttacaaatct agtaaatgat ggggtgagtg
    18001 taaagttagg aatccagaaa ttctgatcta attatgaatt taattactta tactattacc
    18061 gaataattaa agataaggtg atatataaga tgaaaattga agtgaaaaat atttctaaga
    18121 aataccagga tagagaagta ttaaaggatg taagctttac gattgaaaaa ggtactattt
    18181 gtggtttatt tgggatgaat ggtgttggaa aatcaacttt aatgaaaatt atttatggga
    18241 ttgaaatacc agataaagga caagtactat ttgaaggtca cggaaaaact agtaacattg
    18301 gtgctttgat tgaacaacca ccaatttatt cgaatttatc agcttttgat aatttaaaaa
    18361 ctaaagcact tttatatgat attccaaata atcaaattaa agatgtttta aaaagagttg
    18421 gtttagatag cacggataaa aaacatgcag gtaaattttc agttggcatg aaacaaagat
    18481 tggggatcgg aatggctatt ttaacacaac ctaaatttat aattctcgat gaaccaatta
    18541 acggattaga tcctgatggg gttattgaat ttttagattt actaaagtca ttaaaaaaac
    18601 aaggtgtaac tattttgata tcaagtcacc agctacatga aattggaaga atcgtcgatc
    18661 aagttatcat tttagataaa ggacatgttg tatatgataa aattcaaagt aattataaag
    18721 atattgaaga gattttcttt aatgttatga agggagagag tttcatatga taaaagcttt
    18781 gttttctgaa atattgaaat taaaaaaagt tagaataaac aaacttttat ggatcatccc
    18841 tttattaacg ggtttaattg cttttttagt agggggagta attatttttt ctccttttgc
    18901 catatattgg tgggaatctg tttttttata cctactaata ggattattat ttttaatgga
    18961 ttttaatatg gagaaaaaag caggaaactt tcaaaatgtt aagtataatt tgtggagttt
    19021 ccaaatttat ttggcaaaaa ttttcttaat ctttgtacga gttgcaatat caagtctttt
    19081 ttttataata ctagtaattg tcttaaataa gttttttagt ggttatacag aattattact
    19141 aagtaaaagt atactaagta tatttctgtt attgttatct gtattttgga atataccgtg
    19201 gttatatttt ttagctaatt ttataaatgg ctatttgctt atagcagtta atacgttagt
    19261 atgtttatta tttggatcta tcatttctca aacacaatgg tggtttgcat ttccatactc
    19321 gtaccattat aaaatatcac aatatctatt aggggtacag ccctcaggaa tttttaaaat
    19381 tataaattta caactttttg atgttatgag tcctgtatta ctttcattat tgatatcttt
    19441 acttttaata tattttacaa gatggggtaa atcaaatgat tagaagtgaa ttattaaaat
    19501 taaaaagtag tcctactata tacctattag taagtttcac tatttttgaa attgcatcaa
    19561 cctacgggta tttgtattgg catcgaaatt tactaactta taaaaatatt gtactggcat
    19621 ttgctctagc ttatccatct ttaatttctg tgataactaa tatatgcttt gaacaagaaa
    19681 gagaagcaaa taattttcaa gaagttcgta agtatagtca agtgaaatta cttacaataa
    19741 aaacgttaat cttagactta ttattatggt ggatttcatt ttttgtatgg tggataataa
    19801 gttattccat agcccaagtt aaattaggga taatcagcgg aatagcaatg tggctattga
    19861 tagtattact taatcatagt cacatgtttt tatatatggt tactaataaa tatataaatt
    19921 tagtattttc attagtagag attttattta ttatttttgc tagtaataaa actttaatgt
    19981 cagcctattg gtgtttcgta gcatggccta ttaactattt gattcatgca gataatagta
    20041 aactttattt tagtgcaatg tggattttga tattaacaat tttagattat ttcatcttta
    20101 gaagtataga attagaaaga atagactgat attttggggt gatgaaaagc taattttgaa
    20161 tattagacac aggagaaatt ctaaaattta tgcaaataaa gcgatatcaa agtttatttt
    20221 gcataaatta agaaattggt cctatgtcga aattgcccaa attaacctaa cagtttatag
    20281 tttaatgacc taagctttgt tagtatataa gtgtaccgat gaagctagtg gatgaggtgt
    20341 gacaagccgc ctagccatac gtctcttaat aactactatg acgaaatata cggatacgtt
    20401 tattttttct aatttccact tgggtagtac taattgggag caacgaaaaa aagttgtgta
    20461 gagagaagca agggaactca tatctgaaac taagacactt gccgtcaggg attcgcaata
    20521 tgccatcttc agttaattaa ggctgattac cttaggaacc aaagaagaat atcaactaag
    20581 aattcgtgtc gtgaagttgt ggtgacacag ctataactga cgagtaaggt ttgagtagcc
    20641 aaaatcgaca atattacatt aactggaaca ttgcacatgt ttggtgaaaa ttggatagga
    20701 aaaggtctat gccctgaact tgaaatgcgg actaggtcat ggaagttgct agccatgatg
    20761 tgctagtctg attcagtagt ctaataagtc cagatacaag agtatcccac gtaagccaat
    20821 acgcgtcggt ttacataatt tttagtcaat gcaaattttg cgttggctat ttttggtatt
    20881 aaatgttcga ggtatgtata attaaattga ggtgatttca tgaagccaat gtatgtttcg
    20941 ataaattcag aaaaaactgg tgctaatcta aaaagtttat tcaaaaataa tgggtacagt
    21001 gtacgtgata ttcaatcagt tatgggattt gagaacccac aatccattta taaatggtta
    21061 tctggtagat cactacctag tttggataac ttagtcattc tcagtaaggt tctacatacc
    21121 acaatcgaag acatcctcgt tgttgacggg gatgttgttt ttttattcaa tttaacttgg
    21181 actatacagt taaatagata ataattgaaa ggaaacataa aaatgcaaga agtcatgagc
    21241 tatagaggtt acaaaggaac aatagagtat tctttagagg ataatgtttt acatggcgaa
    21301 gttttgggga ttagaagttt attatcctat gaaggaaata cattacaaga attgaaagat
    21361 gattttgaag atacaattga tgattatttt gagtgttgca aaaatcacaa tatgactcct
    21421 gaaaaacctt acaagcagaa cattgtaatt aacttagaac cagatttgta agaaaaatta
    21481 tatttatatt ctgaacttcg tgatgaagat atttctgaca gtataaatag agcgattagg
    21541 aatttggtcg acaaatagga tgtatacttt tacggaaagt gatgtattat gaaaaaaagt
    21601 agagttaata agattaagat agaatctaaa aaagctttag ttgtgcgtag attagattgg
    21661 agggcccctt cttctaggat aaattattct atcttagaga tgatagatga tttaaatgat
    21721 tctaaattag aacgagcaag caatttagct gaattagaga gtttattaaa taagtaatat
    21781 tatttttgcc aaaaattaga aaatacaaac ttataattaa aatttattga caaaagtata
    21841 gtaaggttat atgatttggt taaagaaatg agaggagtgt gaatcactat gtcaaacttt
    21901 atcaatacac aatactgttg tttggtaaca tgttgtccag taggaaacat gggttttggc
    21961 atgcagaaaa ttagattcac acttccaaga ttggattaaa ctgtatatat ttattatcgg
    22021 taccgatgca gattaattta atcagttaga ttatatgaga taataataac tggacttgcg
    22081 attctaattt tttggagttg caagtccttt ttgtttattt ggaaggatgg atgatgaact
    22141 gtttatagat taaaaaacat attttacata aaggggaaaa taaagatgaa aagaattaaa
    22201 gcaattatta ctggaatatt tataagctta accgcaattt tgttagttgc atgtggtaaa
    22261 tcaactggtg aaaattctaa acaagtttta aatctaagta caactggacc attggatacc
    22321 attgatattt ctaagtctac aggttatggt caaactggga atgtttttga aagtttttat
    22381 cgtttaggta aagatggcaa ggtaactcct ggattagcta aaagtggtca agtttcacaa
    22441 gatggcaaaa catggacttt tactttgaga gatgcaaagt ggagtaatgg agataagatt
    22501 actgctcaag attttgtata ttcttggaaa agaacaattg atcctaagac agcttcacca
    22561 tatgcttatt tgttctatga tgtaaagaat gcccaagcta tcaatgaagg taaaatgtca
    22621 gctgataaat taggaataaa ggctgaaggt gataataagg ttgttattac gttagataga
    22681 cctatatcat attttaaagt cttaatgaca tatccattat ttggaccaca aagtgaaaaa
    22741 gtggtacaaa agtatggtaa gaaatatgga actaattcta aatacatggt gtactcagga
    22801 ccatttaaag ttaaagactg gaatggtact tcggataagt ggtcatttgt aaagaataat
    22861 caatattggg ataaaaaagt ggtaaaacta caaaagatta actatcaagt agttaaaaat
    22921 accaatacag gttatcaatt attccaacaa ggtaagttag atttaacacc attatctagt
    22981 gaacaagtta agaatctaca taacaagcca gaattcaagc aatactctta ttcttacgtt
    23041 gcatatttag actataactt taatgattct aatgaagtaa atcgtaaggc actaaataat
    23101 aaaaatatta gattagcttt atcattagcg attgacagaa agacacttac aaagaaagtt
    23161 ttcggcgatg gatctaatgt accaactggt tttgtagcat ctgatttagc tactaatcca
    23221 aaaacaggta aagatttcgc tgcagaacaa aaagtagata atacagttga ttacaatgag
    23281 aaattagcta gagaatattg gaaaaaagga ttacaagaaa ttggtgaaaa gaatttgaat
    23341 ttcacaattc tagcttccaa tgaaatggct aataatgatg ctttaactca atatctacaa
    23401 tcacaatata caaaggtatt gccaggaatt aaggtttccg tacaaaatat tcctggaaat
    23461 agcgcattat ctaaagctcg taaaggtaac tatgacattt atgtatctgg ttggggtgga
    23521 gactttaaag atccaatcac tttcatgcaa attccagtta caggaacttc atacaattat
    23581 ggaaagtact ctaataaaga gtacgatgct ttaattgaaa aagcacaaaa tgaagatgcc
    23641 aatgatgcta ataaacgttg ggaagattta gttaaagctg ctcgactctt taatgctgat
    23701 caaggggtaa cacctctata tcaacaaaca acatcttata tgcaaaatac caaagtaaag
    23761 ggtattattc aaaatactgc aggtacacaa tggaactaca aatacgctta tattaaatag
    23821 gtaagaactc gtctagaatg atttctaggc gagtttttaa gttgtgctaa ataatttgca
    23881 taagagtatt gattatgttg tatgtaagcg ttattctata tttgtaaact tattataaag
    23941 attattactt aattacaaat aaatttaagg atatatattg taaaaatact taaatctaat
    24001 cgttatgttg agtaatttgt cttataatta ttattgataa gaaaattcca ggaaaggtaa
    24061 ctattttata gtggtgattt aaatgtcagt attagaagtt aaagatttac atgtaactgt
    24121 tgaaggaaag gaaatattga aaggtgttaa tttgaagatg tcaactggtg agattcatgc
    24181 aatcatgggt ccaaacggta ccgggaaatc aacactttct tcaactatta tgggcgatcc
    24241 tgcttataag attactaaag gggatatttt gttaaatggt aaaagcatta ttgatttacc
    24301 ggttgatgaa cgtgctagaa tgggactatt tttagcaatg caatatccac aagaaattcc
    24361 aggagtaact aatgcagaat ttgttaagag tgcaattaat gctcgtcgtc ctaaagatga
    24421 tccaattcct ttaatggact tcatcaaacg tttggatgaa actttagaaa cattggatat
    24481 gtctgaagaa atggctgaca gatatttgaa tgaaggcttt tctggtggtg aaaagaaacg
    24541 taatgaaatt atgcaaatga tgatgatcag acctgaattc gcaattttag atgaaatcga
    24601 ctctggacta gatattgatg ctcttaaggt tgtttctcgt ggggttaacc aaatgcgtgg
    24661 cgataatttt ggatccttga tcattactca ctatcaaaga cttttaaact atattattcc
    24721 agattatgta catgttatga tggacggtcg tcttgttaaa actggtggtc cagatttggc
    24781 aatccgtttg gaaaaagaag gatatgcaaa acttcgtgat gaacttggtt tagatattaa
    24841 attagttgat gaaaatgctt agggggcttg tacaatgaaa caactatcca tagatgaatt
    24901 aattgaactt cgaaaagagc ccgaatggtt taaagctaag cgaaatgaag ctaagcaact
    24961 aattgaaact actaaattac ctagtttcca aaagattaaa tatcatgatt ggaacataaa
    25021 tgttgatgga acaactgcaa ttgataatca acctgaattt gataccaatg ctgatgttta
    25081 tcaatatgca agtgacaaag cacaaattaa actaccacaa gaatttcttg ataagggagt
    25141 aattgttgaa gattttgagg atgctctggt taaccatgaa gatattatga agaaatactt
    25201 tatggaaaaa ggactaaaaa tggacgataa tcgtctatta gcagaacatg tagcaaatct
    25261 tcaaagtggt gttttagtct atgtacctaa aaatgtagat ttagaaacac cattaacttg
    25321 tgaatatatc caaaattcac gagttgaagg agattatgtt catcatgtat taattgttac
    25381 ggaagcaaat agttcgctat cttatgtaga acgtttaaaa actgatggtg ataagagtaa
    25441 tacagccaat attgtagttg aagttattgc cggtaatgga agtcgcattc actttgctag
    25501 tgttgataat ttaagtaaga acacaactgc ctatatgaat cgtcgtggat acttacaaag
    25561 agactctaag attgactggg caatgggtat gatgaattct ggtttaacaa tcggtgattt
    25621 tgattctgat ttagttggcg atggctctca tgctgaatta aaagtcgtag gtatttcaac
    25681 aagtgatcaa attcaaggaa tcgatacacg agttacaaat attggaaaga atacgatcgg
    25741 ccatatctta caacatggtg ttgctttaga tgcatccgaa ctaactttca acggcattgg
    25801 acatgtaatg aagagaagta aaggttctga tgcacaacaa gaaagtcgta ttttaatgtt
    25861 atctccacaa gctagagggg atgctaatcc aatcttacta attgatgata atgatgttac
    25921 tgcaggacat gcggcaagta ttggtcgtgt aaatcctgaa caattgt
//
