LOCUS       NZ_CP047144            20732 bp    DNA     linear   CON 30-JAN-2024
DEFINITION  Streptomyces sp. HF10 chromosome, complete genome.
ACCESSION   NZ_CP047144
VERSION     NZ_CP047144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. HF10
  ORGANISM  Streptomyces sp. HF10
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7814787)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Multiple polyene macrolides produced by antifungal Streptomyces from
            gut of Macrotermes barneyi facilitates the termite-fungus mutualism
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7814787)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-DEC-2019) State Key Laboratory of Microbial
            Technology, Shandong Unversity, 72 Binhai Road, Qingdao, Shandong
            266237, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-NOV-2018
            Assembly Method                   :: SPAdes v. NOV-2018
            Assembly Name                     :: SDU_Sthf_5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 05:29:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 6,988
            Genes (coding)                    :: 6,640
            CDSs (with protein)               :: 6,640
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 356
            CDSs (without protein)            :: 348
            Pseudo Genes (ambiguous residues) :: 0 of 356
            Pseudo Genes (frameshifted)       :: 235 of 356
            Pseudo Genes (incomplete)         :: 154 of 356
            Pseudo Genes (internal stop)      :: 18 of 356
            Pseudo Genes (multiple problems)  :: 53 of 356
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:39:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6593686
            Orig. end                         :: 6614418
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jinfeng Ni.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20732
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="25"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20732
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20732
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10732](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10732)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    551..563
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     misc_feature    complement(2552..2567)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 24.97"
                     /tool="antismash"
     gene            complement(2669..3205)
                     /locus_tag="GR129_RS29275"
                     /old_locus_tag="GR129_29275"
     CDS             complement(2669..3205)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982414.1"
                     /locus_tag="GR129_RS29275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29275"
                     /product="isochorismatase family cysteine hydrolase"
                     /protein_id="WP_159706425.1"
                     /transl_table=11
                     /translation="MKNTALLVIDMINTYDHKDADLLIPSARTVVPVVADLLRRARDLS
                     APVIYVNDNFGEWRSHHGELLDHALHGPHSDLVKPLRPDRDSLFVVKARHSVFFETPLE
                     YLLRQQNVDRLVLTGQVTEQCVLYSALDAHIRHFEVIVPRDAVAHIHEDLARAALRMME
                     RNMGARVCTSRDLWR"
     gene            complement(3290..5965)
                     /locus_tag="GR129_RS29280"
                     /old_locus_tag="GR129_29280"
     CDS             complement(3290..5965)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027393.1"
                     /locus_tag="GR129_RS29280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29280"
                     /product="MXAN_6230/SCO0854 family RING domain-containing
                     protein"
                     /protein_id="WP_159706427.1"
                     /transl_table=11
                     /translation="MLAAESVLLRRIQTVYVDGPSSSGGGTGPALRRLEAELLGRGHVL
                     CAELHTVLGSLTAEELAVAHARVVGLVDDLLGSDRVHIPLLRRFPHTVPRDTEALYVDR
                     VFAFLLQQPDHPCVLCGEARTVFPVSPCAHLVCRLCWDGSDYAGCPVCHRRIDADDPFL
                     RPVRAVGAAKAPLPGPLRLLRFGTDMKADATTVVDSLLARRTPLSPQDRGDLLTLLPLT
                     PAGRGLLPQEIPVRETKATVLGALIREAPDGLPVRKLLTERLTTATDVLRLLAALSDGD
                     AGLVTLSPFTGLPRPLRRELLAVLDALPTPYLVEDVLRHPTAWKRAAEVLHPFERHARH
                     PRAALAFAVLRGTRVDPGTAFGAALLETAAAHPDAVRVDSSRMGNARTDGFPGDSARMD
                     GSSVDGVRLRPATWAGRLEQALAEGDAGRAAALAGERPGELVRRLDLLLRLHPRDTLVP
                     ELEKALLRGLPKVGPGPLLSALGALRVRAEDRTGRRRVFFPRGDVTRALSVPERRPALP
                     AALVTAAVTLLEAELLRRFAAGEPYELSVLDAGLADLTVPFTERSTARALVAVPRGSTQ
                     TLPEGAVLRLFLHWTEPEGVRTDLDLSVAFFDAEWGFTGLCDYTNLVHGTRAAVHSGDL
                     TSAPAPQGATEYVDLDLERLAERGDVYAVPLVFSFNNVPFEELRDAFAGFMALPAQGPR
                     DASYDPRTVRQRFDLAGESRVCLPMVVDLGRRRMLWTDTHLTSRPGFQSIGSHGGSQLS
                     TVARDLWEQFGSGSRTTLWDLAAWRAAARSPEVAVVCREPEPALLRFRRRPNEDAAAFA
                     ARVSSLAEAEERLPHPDPGTAAAELGSGTRVFLATVHGSIGPARASGTYYRLFPGAGDA
                     SESLVRVTAGDLVAELGGGS"
     gene            complement(6241..6558)
                     /locus_tag="GR129_RS29285"
                     /old_locus_tag="GR129_29285"
     CDS             complement(6241..6558)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550005.1"
                     /locus_tag="GR129_RS29285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29285"
                     /product="hypothetical protein"
                     /protein_id="WP_159706429.1"
                     /transl_table=11
                     /translation="MTTHRTRRRTTRTAAALTACSTATFAVLLTGCSTADAICSNGEYP
                     VQNIGATGGQCVPDGHKVPKGTFRYPEDKTPKHVDDKWDIYWQTHTLDKHGTIIKAPQD
                     S"
     gene            complement(6731..7675)
                     /locus_tag="GR129_RS29290"
                     /old_locus_tag="GR129_29290"
     CDS             complement(6731..7675)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="GR129_RS29290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29290"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_159706431.1"
                     /transl_table=11
                     /translation="MGRTENPVLRPTSALGGLACYLRWCKARAGLTNKALAYRTKYSAT
                     TLQRASGGAVLPTLRVVLAYEAACGLADGEARALWLKARRAEGRRDRRRATSGRPGKAP
                     RPDLIADRADMSHALADLRDRAGLSYRAMERRVEERPELVQLSRSTAQRILTRQAFPTS
                     QSQLMAVLHACAVPERTWGDWIRAWKKVHRAPDRLEPAVTPARKLLAREAEAELACFKL
                     EAVEPFRSPTAAWSVRCCLCGALFRVQLSGLGHGWTGCPNRCPRDRARPATTGQLAPST
                     CPRCELPATDTLAADSPATGCPVCDTPVRPTPD"
     gene            complement(7682..7948)
                     /locus_tag="GR129_RS29295"
                     /old_locus_tag="GR129_29295"
     CDS             complement(7682..7948)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR129_RS29295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR129_29295"
                     /product="hypothetical protein"
                     /protein_id="WP_145489846.1"
                     /transl_table=11
                     /translation="MHVNDTMALCVVPDTSSSRSLSGADAAVVVVIIIVAAVLSADGMP
                     VREVMALLGAAGLLSVSVTRLGSGAAARALRQLARAQSDTLPR"
     misc_feature    complement(7793..7795)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8100..8114
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(8486..9736)
                     /locus_tag="GR129_RS29300"
                     /old_locus_tag="GR129_29300"
     CDS             complement(8486..9736)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010267454.1"
                     /locus_tag="GR129_RS29300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29300"
                     /product="hypothetical protein"
                     /protein_id="WP_159706434.1"
                     /transl_table=11
                     /translation="MDDDIQLMSDGEGLAVIGSPAAVERFLVSEGLPSKDLGLPRLGSA
                     LGAMAGATQAGSGIAAESGRWVKLTEQSAQALKKHRLMKGSHADASRAVLTENGKIKGL
                     LELVRTPGSLLTNPTLLAGAAGLMAQLAMQQTMDEITDYLAAIDKKVDDVLRAQKDTVL
                     ADMIGAGFVIEEAMTIREQVGRVSEVTWSKVQTTSMTIARTQAYALRQLDALAEKMENK
                     TRIGDLARAAKDAEVGVREWLAVLARCLQLHNAIGVLELDRVLDASPDEVDRHRLALRA
                     ARQNRMELISRSTERLMARMDTAVGTANTKVLLHPTASPAVVHSSNHVATAVVDFRERL
                     GIERDRRSSDARRWVDAAAETRDKVLETGAEGVDAARRLGIETFDRARSVTGKLSSGFT
                     ERVLRRRGDGEERGREG"
     misc_feature    complement(9747..9761)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.96"
                     /tool="antismash"
     misc_feature    complement(9948..9962)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.98"
                     /tool="antismash"
     gene            complement(10001..10732)
                     /locus_tag="GR129_RS29305"
                     /old_locus_tag="GR129_29305"
     CDS             complement(10001..10732)
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.4"
                     /locus_tag="GR129_RS29305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29305"
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_236576529.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 6e-05,
                     bitscore: 21.0, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 3.2e-14, bitscore:
                     51.5, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAATAVMHHGDNLLDTDPLPQREAAWADWERQVRDALRTGTSDSP
                     LLRTLAHTVAAHPRLGGLVDTYLATATAEPHCTGFATEADYQAYVDAYSYPAFMLVAGL
                     LAPEADDLPYRAACRTFIEGSQRLDFVNDLAEDIEEGRTGIPVEAMERFGVTPDDLRTG
                     VGGSPLSALIADQVATVQRSLSAAKPLHTLASPGGRCLAGALVEIELLTAKAVLARGTG
                     ILHGSASPPLGKTLRALTRTY"
     gene            complement(10984..12435)
                     /locus_tag="GR129_RS29310"
                     /old_locus_tag="GR129_29310"
     CDS             complement(10984..12435)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046446.1"
                     /locus_tag="GR129_RS29310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29310"
                     /product="MFS transporter"
                     /protein_id="WP_159708717.1"
                     /transl_table=11
                     /translation="MDAPQPSRRTGGVVATLALAGTVAAIMQTLVTPLIAELPRILHTS
                     SSNAAWVVTVTLLVGGVCVPVSGRLGDLVGKRQMMLICVVPLVIGSVVCALSASVVPMI
                     VGRGLQGMGMGMIPLGIALLRDVLPAEKLSGSIALVSASMGIGGAIGLPLAAAVAQYAD
                     WQLLFWGSAALAVIVGVLIFVVVPDVPAGAKGQRFDALGALGLAIGLVALLLAISKGAD
                     WGWASGSTLVLFAVAVVALPAWGFWELRTRDPLIDLRTTARPRVLITNAASVLIGVGMY
                     SFMLIAPQLLQFPKATGFGLGQSMLAAGLWIAPGGIMMMVISPLGGKLINARGPKLALT
                     CGAVVMAAGYALALPLMGTAWGIMLSGIVINSGVALAYGSMPALIMSSVPLSETAAANG
                     FNTLMRSLGTTIGSAVIGVVLAHMTIDLGGYTIASEDGFRTGLLIGCGVALVSAAVASF
                     IPSPRKAADAPAPHPTETGPAPVRR"
     misc_feature    complement(12563..12581)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     misc_feature    12566..12584
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.24"
                     /tool="antismash"
     misc_feature    complement(12570..12588)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    complement(12583..12603)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.27"
                     /tool="antismash"
     misc_feature    complement(12641..12654)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            12675..13127
                     /locus_tag="GR129_RS29315"
                     /old_locus_tag="GR129_29315"
     CDS             12675..13127
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946681.1"
                     /locus_tag="GR129_RS29315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29315"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_145489853.1"
                     /transl_table=11
                     /translation="MGKPSHLVEFEHMVLGRHQLSSTTRRHQEGRMERSAYIMLSRIEV
                     QGPMTIGQLSDAFQLDVSTVNRQTAHAMRAGLLERIPDPEGGMARKFRLTGEGERKLRE
                     ERALHVQDLDRVFEDWSADDVQNFARYLQRFNTSVERITGQPWPRS"
     gene            complement(13397..15256)
                     /locus_tag="GR129_RS29320"
                     /old_locus_tag="GR129_29320"
     CDS             complement(13397..15256)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070784.1"
                     /locus_tag="GR129_RS29320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29320"
                     /product="DUF4157 domain-containing protein"
                     /protein_id="WP_236576530.1"
                     /transl_table=11
                     /translation="MHEHRKRHEDPTPKGSRPRSTTARAAGAQRPGQAGAPPPDAMASL
                     QRLIGNAAVGEMLERAGAERSEAAEQQSAAVRGVLRSPGRPLDDSVRGDMEARLGADFS
                     DVRVHTDRAAHESAASVSAEAYTSGAHIVFRKDRYDPSSEAGRTVLAHELTHVVQQRRG
                     PVAGTDTGGGLAVSDPSDRFEREAERVARRVTADGAAAGAVDGGAAGAVADGSGRAPVA
                     AAHAGAGLAVARLMSVAEFQGSTTVGPLQKRGGSIVAVEQALTTCHGPTARPDNFAGRA
                     DQLDNLVQAAQNYLAHSKSGRHAQVVQDLLDDCQPEAAIFRQLANAVGLAAPLPKARAL
                     LTAQEAVLQRVRTAHLDINSEVSMANVHLHNPLLQAVNALTDAEKSTLVGDDLQLLDQI
                     RTDPNAPQVTRDTLGDLLANRGIVNFTTGMPGTKLSEPGVAEKYTLKHMMVQGDGATER
                     LGSLAHELTHVDAGESFGNTQILLLLRQNLADAEITALATQRKGRVDTLQALLDSDGTL
                     TEDQKNLFRSKLTYATDPAKGVARYAMLFKGKLDDATYQRLMQIEKLSAPNSSTLVEYD
                     TVVTQLLVYLHRWGVDPANPLYTAVTQLATELRNDRRAAAAGH"
     gene            <15781..15897
                     /locus_tag="GR129_RS29325"
                     /old_locus_tag="GR129_29325"
                     /pseudo=""
     CDS             <15781..15897
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010638801.1"
                     /locus_tag="GR129_RS29325"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29325"
                     /product="alpha/beta hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RTAELVPGAELLLLPDMGHDRPRELWPTPTDALVVHTG"
     gene            complement(15939..16385)
                     /locus_tag="GR129_RS29330"
                     /old_locus_tag="GR129_29330"
     CDS             complement(15939..16385)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019984173.1"
                     /locus_tag="GR129_RS29330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29330"
                     /product="ASCH domain-containing protein"
                     /protein_id="WP_145489861.1"
                     /transl_table=11
                     /translation="MSADDLPKLALAFPGPERDSGVEAIISGRKTAMTALVEILERMGQ
                     PLPEAGQRYAVLDSDDRTAVVIELTEARVIPFGEVDDRFALDEGRGYANAREWAAAHRD
                     FFRGAQVTELLGHTPVVDDDALIVAERFRVVDAADRNVSGRSRP"
     gene            complement(16541..17809)
                     /locus_tag="GR129_RS29335"
                     /old_locus_tag="GR129_29335"
     CDS             complement(16541..17809)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150689.1"
                     /locus_tag="GR129_RS29335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29335"
                     /product="S53 family peptidase"
                     /protein_id="WP_186337947.1"
                     /transl_table=11
                     /translation="MHSHRRRTGIRRSAPALLSAAALITGGVAVATQTSAFATTPAASH
                     AATTSAATSVHTHRLCSQPSKPGYMACQSVERTDIAQHKSLGRNDTPQGFGPSDLAAAY
                     NLPKDGGKGQTVAIVDANDDPNAEKDLAAYRSQYNLPECSTDNGCFKKIDQDGGSNYPT
                     PDAGWAGEISLDVDMVSAACPQCNILLVEAKSANMDDLGAAVNQAVKQGAKFVSNSYGG
                     SEGSDDTTADDQYFKHPGVAITVSSGDSGYGVEYPAASQYVTAVGGTSLKKDSSSRGYS
                     ETVWGTSAGGDGAGSGCSQYEAKPSWQKDTDCAKRAVADVASVADPATGLAVYDTYQAS
                     GWNVYGGTSAAAPFIAGVYALAGAPGSGDTPASYPYSHPDQLNDVTSGSNGSCDVAYLC
                     QAGKGYDGPTGLGTPNGTGAFTK"
     gene            18049..18450
                     /locus_tag="GR129_RS36200"
                     /old_locus_tag="GR129_29340"
     CDS             18049..18450
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014080.4"
                     /locus_tag="GR129_RS36200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29340"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_159706436.1"
                     /transl_table=11
                     /translation="MELDDATVNRLTSLGLARYEARIHLSLIRRGSCTAAEVAREADVP
                     RRRVYDVLDALVRRQLAAARPGRVTTYSAVSPELALARLMSAQRETVDRLGRASRELAG
                     LPGPLRTQGREHTAPPGLHRGAARPEGDR"
     gene            18447..18857
                     /locus_tag="GR129_RS36205"
                     /old_locus_tag="GR129_29345"
     CDS             18447..18857
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR129_RS36205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR129_29345"
                     /product="hypothetical protein"
                     /protein_id="WP_159706438.1"
                     /transl_table=11
                     /translation="MNVLPIFGFRPVTNSSPFANPLCRAAREHGGHHRSAPPPSERRTV
                     RAIYLSDTLADPGTADHVRRFAAAGEEVRFAPALPLKLVIADAALVLCDLPDPVAGAGT
                     TTTLFIEHPALAACLRLAFHTVWATARPGPES"
     gene            complement(19014..20027)
                     /locus_tag="GR129_RS29350"
                     /old_locus_tag="GR129_29350"
     CDS             complement(19014..20027)
                     /NRPS_PKS="Domain: PKS_ER (14-260). E-value: 7.4e-27.
                     Score: 86.2. Matches aSDomain:
                     nrpspksdomains_GR129_RS29350_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389505.1"
                     /locus_tag="GR129_RS29350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_29350"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_159706440.1"
                     /sec_met_domain="ADH_N (E-value: 9.2e-16, bitscore: 56.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.9e-23, bitscore:
                     80.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQMLAARLHIPSRTLRIEEVARPEPGPGQVLVKVEAAGVCLSDV
                     HLIDGTLTPLLLRGDTVTLGHEVSGTIAETGPGVTRWTPGQRVVLYAGEIREGVAYTRG
                     VDYDGGWAEYALSSEHALTELPEAIPFDQGAIIPDAVSTPWGAITVTGAVRPAEAVGVW
                     GVGGLGVHAVQLLRAVGACPVVAIDPNPTARERALAQGADLALDSADPALRERIREATG
                     GAGLAAAFDFAGVPAVRAQALSVLAPKGRLVLVGLTDQPLTVADGTRFSYLQQQILGHY
                     GSDMPVALPQLLSLIRGGRLDFSASISGELPLSRAAEAVERLEKKTGDPIRLILRP"
     aSDomain        complement(19248..19985)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GR129_RS29350_PKS_ER.1"
                     /evalue="7.40E-27"
                     /label="GR129_RS29350_PKS_ER.1"
                     /locus_tag="GR129_RS29350"
                     /protein_end="260"
                     /protein_start="14"
                     /score="86.2"
                     /tool="antismash"
                     /translation="TLRIEEVARPEPGPGQVLVKVEAAGVCLSDVHLIDGTLTPLLLRG
                     DTVTLGHEVSGTIAETGPGVTRWTPGQRVVLYAGEIREGVAYTRGVDYDGGWAEYALSS
                     EHALTELPEAIPFDQGAIIPDAVSTPWGAITVTGAVRPAEAVGVWGVGGLGVHAVQLLR
                     AVGACPVVAIDPNPTARERALAQGADLALDSADPALRERIREATGGAGLAAAFDFAGVP
                     AVRAQALSVLAPKGRLVLVGLTDQ"
ORIGIN
        1 cacggcgacg ccgcgaagtc ctccggtacg ggtacgccct cgccgtcgtc ctccccggcc
       61 ccgagcaccg gcaccacgcc cacgtctacg accacaccct cggccacgaa caaggccgcc
      121 cagccgccca ccacgggcgc gaacgggatg tacctgacct tcgacacctc ctcgaacccc
      181 acggtgaagg cgaaggtcgg catctcctac accagtgacg ccaacgcggc ggacaacctc
      241 accaccgaga tcaggaactg ggacctggac gcggtgcagc gggcgaacca cgacgcctgg
      301 aacacggtgc tggacaggat ccggatcggc ggcggcacca aggaccagca ggtgcagttc
      361 tacacggcgc tctaccacgc gctgctgcac ccgaacgtct tctcggacga caacggccag
      421 tacatgggca tggacaacca ggtccacaag ctggccaagg gccagcgggc ccagtacgcc
      481 aactactcgg gctgggacac ctatcgctcc cagacccagc tgatggcgat ggccgagccc
      541 aaggtcacca gtgacgtcgt cacctcgatg ctcaacggct acgaccagac gggcctgctc
      601 cccaagtggg cctcgaacaa cggcgagagc tacgtcatgg tcggcgaccc ggcggccggc
      661 atcatcgcgg acgcgtacgc cttcggcgcc cggagcttcg acacggacaa ggcgctcgcc
      721 gccctccagc acgaggccac cgcgccgaac aacgaccgcc ccggcgagtc cgtacgggac
      781 gccaagggct acctcccgct ggacgagaac gactacgggt gctgcaactt ctacggcccg
      841 gtctccacac agctggagta cgactccgcc gactacgccc tcgcggcctt cgccaagtca
      901 ctgggcagga cggccgttta ccagaagttc gccactcgcg cccaggactg gatgaacgtc
      961 ttcaacccgc agaccggcta catgcaggcg aaggacaagg acggccgctt cgcgggcggg
     1021 ttcaccccgg gcacctccaa cggcttcgtc gagggtacgt cggcccagta cacgccgatg
     1081 gtcccgttca acctgaagca gctcatccag gcgcgcggcg gtgaccaggc gtactcgtcc
     1141 ttcctggaca gcctgctcga caacatcacc gaccccggca acaccgacgc caacctgagc
     1201 aacgagccca gcgtggagat cccctgggag tacgactaca cgggccagcc gtggaagacc
     1261 caggaggccg tccgcgcggc gcagctgaat ctgtacttca acgcgccggt cggctcgttc
     1321 ggcaacgacg acctcggcgc gatgagctcc tggtacgtct ggtccgagct gggcatgtac
     1381 cccgagaccc cgggcacgga caccctggcg ctcggcagcc cggccttccc ggtggcgcag
     1441 gtgacgcccg ccggcggcgg gacggtgcgg atcaacgcgc cgcaggcggc acccgacgcg
     1501 ccgtacgtgc actcgctcga cgtcaagggc aaggagtgga acgcctcctg gctgacgtac
     1561 gggcagttca agggcgcggg caccctggac ttcaccctcg gcacccagcc ggacaagtcc
     1621 tgggcctccg gtccgtcggc ggtgccgccg tcggacacca cgggcgggga ccgcgtcctg
     1681 gccgctgccg gtccggccag tgacggcctg gtgctccagc cgggcgcgtc cggtgacggc
     1741 acgctcgatc tcaccaacct cggtggcaag gacgtcaccg tcgactggaa ggcgaccgcg
     1801 ccgtcgggtg tcacgctgga cccggcgtcc ggctcggtga aggtgcccgc ctcgggcagc
     1861 gcggaggcga aggtgcgcgt cacggcgggc gcgagcgagg ggacgtaccc cgtcgccttc
     1921 gcgctgaccg accacgacac cggggcggca ctgaacgggg cggccctgcg ggtcgccgtg
     1981 gccaaggccg gtgagctgtg gccgtacgac accaacgagg gcatctatcc cgacggtacg
     2041 gccttctcgg gcggcttcga caacggcggc tgggcgttct cgcagaacgc gctgtcggcg
     2101 gccggggcca cgagcggctc cacgctcacg gtcgacggcg tcgcctacac ctggccggcg
     2161 gtcgcgtccg ggcagctgga caacctggag atggccggcc agaccatccc gatgccggcc
     2221 ggtacgtcgg gagcgtcact gggcctgctg ggtacggcga ccaacgcgcc gacggacggc
     2281 agcggcgtct cgggcacgct gaccgtcacc tacaccgacg gcagcaccgc caaggccacg
     2341 gtcggcttct cggactggac gctcaacgcc ggttcgacca aaccgatggc gggcgacacc
     2401 acggccgtca cgacgggcta ccggaacacc ggcagcggcg gccgcgacgg cgtgaagacc
     2461 tacgtcttcg cgaccaaggt cccgctcgac gcgtccaagc aggtggcctc gatcaccctg
     2521 ccggtgacgg gctcctcggg cagcgaccac ctgttcgcct acggcttcgg ccggtgacac
     2581 ccgggagacg gtgacacccg gaagacggtg acggcggtgg gccggtcccg gcggcgcgaa
     2641 ccgcggggac cggccctctc ggcgccggtc accgccacag gtcccggctc gtgcacacgc
     2701 gcgcgcccat gttccgctcc atcatccgca gcgcggcccg ggcgaggtcc tcgtggatgt
     2761 gggccactgc atcccggggg acgatcacct cgaagtgacg gatgtgggcg tcgagggccg
     2821 agtagagcac gcactgctcg gtcacctgcc cggtcagtac cagccggtcg acgttctgct
     2881 ggcgcaggag gtattccagg ggggtctcga agaagacgga gtggcgggcc ttgacgacga
     2941 agagggagtc ccggtccggc cgcaacggct tcaccaggtc gctgtgcggg ccgtgcaagg
     3001 cgtggtcgag cagctcaccg tgatgggagc gccactcacc gaagttgtcg ttcacataga
     3061 tcaccggtgc ggagaggtcc cgcgcgcgtc gcaggaggtc cgccacgacc ggtacgaccg
     3121 tccgggccga gggaatcagc aggtcggcgt ccttgtggtc gtacgtgttg atcatgtcga
     3181 tgaccagcag agcggtgttc ttcaccctcg ccgagttccc tgtttgcggg gggcgcatcg
     3241 gcctgcggcg cgtcgtcgag gtgtcaccgg cgacgcgccg ggcaggcttc tacgagccgc
     3301 cgccgagctc ggcgaccaga tcaccggcgg tcacacggac cagactctcc gaggcgtccc
     3361 cggctccggg gaagagccgg tagtacgtgc ccgaagcccg tgcggggccg atggagccat
     3421 ggaccgtcgc caggaacacc cgggtaccgg agccgagttc ggccgccgcc gtgccggggt
     3481 ccgggtgcgg cagccgctcc tcggcctccg ccagggagga gacccgggcg gcgaacgcgg
     3541 ccgcgtcctc gttcggccgg cgccggaagc gcagcagcgc gggctccggt tcccggcaca
     3601 ccacggccac ctcgggggag cgcgccgccg cccgccacgc cgcgaggtcc cagagggtgg
     3661 tccggctgcc ggaaccgaac tgctcccaca agtcccgggc cacggtggag agttgggaac
     3721 ctccgtgcga gccgatgctc tggaagccgg gcctggacgt cagatgggtg tccgtccaca
     3781 gcatgcggcg ccggcccagg tccacgacca tcggcaggca cacgcgtgac tcgcccgcca
     3841 ggtcgaagcg ctggcggacc gtacgcgggt cgtacgacgc gtcgcgcggg ccctgcgcgg
     3901 gcagcgccat gaaacccgcg aaggcgtccc gcagctcctc gaacggcacg ttgttgaagc
     3961 tgaagacgag cgggacggcg tacacatcgc cccgttccgc cagccgctcc aggtccaggt
     4021 ccacgtactc ggtggcgccc tgcggggccg gggcggaggt gaggtcgccg gagtggaccg
     4081 cggcccgcgt gccgtgcacg aggttcgtgt agtcgcacag gccggtgaac ccccactcgg
     4141 cgtcgaagaa cgcgaccgac aggtccaggt cggtgcggac gccctccggt tcggtccagt
     4201 gcaggaacag ccgcagcacc gcgccctcgg gcagggtctg cgtgctgccc cgaggtaccg
     4261 ccaccagcgc cctcgcggtg gaccgctcgg tgaacggcac ggtcaggtcg gccaggcccg
     4321 cgtcgagcac cgacagctcg tacggctccc cggcggcgaa ccggcgcagc agctcggcct
     4381 ccagcagcgt gaccgccgcg gtgaccagtg cggcgggcag cgcgggccgc cgctccggaa
     4441 cggacagggc gcgggtgacg tcgccgcgcg ggaagaacac ccggcggcgg ccggtgcggt
     4501 cctcggcgcg gacccgcagg gccccgagcg ccgacagcag cggccccggg cccactttcg
     4561 gcaggccgcg cagcagggcc ttctccagtt ccggcacgag ggtgtcgcgg gggtgcaggc
     4621 gcagcaacag gtccagacgg cgcaccagtt cgccggggcg ttccccggcg agggcagcgg
     4681 cccggcccgc gtcgccctcg gccaacgcct gttccagccg cccggcccag gtggctgggc
     4741 ggagccggac gccgtccacg gaggaaccgt ccatgcgggc actgtccccg gggaaaccgt
     4801 ccgtacgggc attgcccatg cgggaactgt ccacgcggac ggcgtccggg tgtgcggcgg
     4861 ccgtctccag cagggcggcg ccgaaggccg tgccgggatc cacccgggtt ccgcgcagca
     4921 cggcgaaggc gagggcggca cgcggatgcc gggcgtgccg ttcgaagggg tgcagcacct
     4981 ccgcggcccg cttccacgcg gtggggtgcc gtaggacgtc ctccacgagg tacggcgtcg
     5041 gcaacgcgtc gagtaccgcg aggagttcgc ggcgcagcgg gcgcggcagg ccggtgaagg
     5101 gcgacagtgt gaccagcccg gcgtcgccgt cggagagcgc ggcgagcagc cgcaacacgt
     5161 cggtggcggt ggtgagccgc tcggtcagca gcttccgtac gggcaggccg tccggtgcct
     5221 cgcggatcag cgcgcccagc accgtcgcct tggtctcccg gaccgggatc tcctgcggca
     5281 gcaggccccg gccggccggg gtgagcggca gcagggtgag caggtcgccg cggtcctgcg
     5341 gggagagcgg agtgcgacgg gccagcaggg agtccaccac ggtggtggcg tcggctttca
     5401 tgtcggtgcc gaaacgcagc agccgcagcg ggccgggcag cggtgccttg gcggcgccga
     5461 cggcacgcac cggccgcagg aaggggtcgt ccgcgtcgat ccggcggtgg cagaccgggc
     5521 agcccgcgta gtcggacccg tcccagcaca gccggcacac caggtgcgcg cagggcgaga
     5581 cggggaacac cgtgcgcgcc tcgccgcaca gcacgcaggg gtggtccggc tgctggagca
     5641 ggaaggcgaa gacccggtcc acgtacagcg cctcggtgtc ccggggcacg gtgtgcggga
     5701 agcggcgcaa gagcgggatg tggacgcggt cgctgccgag caggtcgtcg accagaccga
     5761 ccactcgggc gtgcgcgacc gccagctcct cggcggtcaa cgagccgagc acggtgtgca
     5821 gttcggcgca gaggacgtga ccgcggccga gcagttcggc ttcgagccga cgcagtgccg
     5881 gtcctgttcc gccgccggac gaggacggtc cgtccacgta gacggtctgg atacggcgca
     5941 gcagcacgga ctcggcagcg agcaacaggg ggttcctcca cggtgacttg ggacagaaga
     6001 acgggggcgg agagtgggcg cgccgggtct tttcgaagaa ggtgagaagg atgcgcgccg
     6061 gggagccgcc cccgttgccc tgatctcatc acaacgccgc gcggggacca aacgaattat
     6121 cgggcggatg ccaggagttc gcggccggat gccagaaggg tgcctgccgc cggggagcca
     6181 caagggcgcg cgccgccagg gcacttcacc ccttcgccgg ccgtcgtcgc cgggtggccg
     6241 tcaggagtcc tgcggtgcct tgatgatggt gccgtgcttg tcgagggtgt gcgtctgcca
     6301 gtagatgtcc cacttgtcgt ccacgtgctt cggcgtcttg tcctcggggt aacggaaggt
     6361 gcccttcggg accttgtggc cgtcggggac gcactggccg ccggtggcgc cgatgttctg
     6421 cacggggtac tcgccgttcg agcagatcgc gtcggcggtc gagcagccgg tgagcagcac
     6481 ggcgaaggtg gcggtggagc aggcggtcag tgccgcggcg gttcgggtgg tccgtcggcg
     6541 ggtgcggtgc gtggtcatgt gtttcccctc ggacgggatc ggcggccttc gacggaccaa
     6601 gcctgacgga gggcgggggt cgcgcggatc ggtacgcgta ctcattcgcg gaggccggga
     6661 acgtgagtac ctgcgcgcag aggcgtcgtt ctcctctctc gtcgaaccgc caacgggccg
     6721 ctgtagccgg tcagtccggg gtgggccgta ccggggtgtc gcagaccggg cagccggtgg
     6781 ccgggctgtc ggcggcaagg gtgtccgtcg ccggaagctc gcaccgcggg caggtcgagg
     6841 gggcgagctg tccggtggtg gcgggccggg cgcggtcgcg cgggcagcgg ttggggcacc
     6901 cggtccagcc gtggccgagg ccgctgagct gaacccggaa gagggctccg cacaggcagc
     6961 agcggacgct ccacgccgcc gtggggcttc ggaacggctc cacggcctcc agcttgaagc
     7021 acgccagttc ggcctcggcc tcgcgggcca gcagcttgcg ggccggggtg acggcgggct
     7081 ccagacggtc cggcgcccgg tgcaccttct tccacgcgcg gatccagtca ccccaggtcc
     7141 gctcgggcac cgcgcaggcg tgcagcacgg ccatcagctg cgactggctg gtggggaagg
     7201 cctggcgcgt gagtatgcgc tgggccgtcg acctcgacaa ctgcaccagc tcgggccgtt
     7261 cctcgaccct gcgctccatg gcgcggtagc tcagcccggc gcggtcccgc aggtccgcga
     7321 gcgcgtggct catgtccgcc cggtcggcga tcaggtccgg ccggggcgcc ttccccggac
     7381 ggcccgaggt cgcgcgccgc cggtccctgc gcccctcggc gcgcctcgcc ttcagccaga
     7441 gggcacgcgc ctcgccgtcg gccagcccgc aggccgcctc gtaggccagc acgaccctga
     7501 gtgtcggcag tacggccccg ccggatgccc gttgcagcgt cgtggcgctg tacttggtac
     7561 ggtacgccaa cgccttgttg gtgaggccgg cgcgggcctt gcaccacctg aggtagcagg
     7621 cgagtccgcc aagggcgctg gtcggacgca ggaccgggtt ctcggtgcgg cccacgaccg
     7681 gctaccgggg cagggtgtcc gactgcgcgc gggcgagctg acgcagcgcc cgggccgcgg
     7741 cgccggagcc gagacgcgtg acggagaccg acaggagccc ggcagcgccg agtaacgcca
     7801 tgacctccct gaccggcatg ccgtccgccg acaggacggc cgccacgatg atgatcacca
     7861 cgacgacggc ggcgtccgct ccgctgaggc tccggctgga agaggtgtcg ggtacgacgc
     7921 agagcgccat ggtgtcgttc acgtgcatgt gcggttccct acgggtgcgg atctcacggc
     7981 ggacgccgtg ggtctggctc caacaattgg tcataggcca cgggcagttg acgctacgtc
     8041 gtgacgcgac agcatggtgc caccgcacga gcccccggac atgccattga tgcctactcg
     8101 tctcatctgt cgatttgaag cagatgcgct tttcaggtca caccgtcttc gggacagtgg
     8161 gtgttcaatt ccggcggccc tgtggcctgg ccgttcttca cgcccgtccg gggggttgcc
     8221 tcaccgcgcc ctgggcaaga ggtggtttcc tgcgttccgt cccagttctt tttgctggcg
     8281 acggcgcgga ctgcgacgat ccctgcgcaa tcccgtacgc gactggctcc aacaccaacc
     8341 gcacggattc ggtggtccct gttgacgcac ggacgaccca aacggccggc ttcggcgacg
     8401 ccggggccgg ccgtacgtgt ccgagagggg agccgtcggc attcgacggc gaccggcccg
     8461 ccgccgatgc cttcgtaccg cctgctcagc cttcccggcc gcgttcctcg ccgtccccgc
     8521 gccgacggag cactcgctcg gtgaagccgc tcgagagctt gccggtcacc gatctggccc
     8581 ggtcgaaggt ctcgatcccg aggcgcctgg cggcatcgac accctcggct cccgtctcca
     8641 ggaccttgtc cctcgtctcc gcggccgcgt ccacccatcg tcgcgcgtcc gacgaccggc
     8701 gatcgcgctc gatcccgagc cgctcgcgga agtcgacgac ggcggtcgcg acatggttgc
     8761 tggagtgcac cacagccggg gacgcggtcg gatgcagcag caccttcgtg ttggccgtgc
     8821 cgacagccgt gtccatgcgg gccatcagcc gctcggtgct ccgtgagatg agctccatcc
     8881 ggttctgccg ggcggcccga agcgcgaggc gatgccggtc cacctcatcc ggagacgcgt
     8941 ccagcacgcg gtcgagttcg agcacgccga tcgcgttgtg cagttggagg cagcgagcca
     9001 ggactgcgag ccactcccga acgccgacct cggcgtcctt ggcggccctg gcgagatcgc
     9061 cgatcctggt cttgttctcc atcttctcgg ccagcgcgtc gagttgacgc aacgcgtagg
     9121 cctgggtgcg cgcgatcgtc atcgaggtgg tctgcacctt cgaccaggtg acctcggaga
     9181 cgcgacccac ctgctcgcgg atggtcatgg cctcctcgat gacgaagccc gctccgatca
     9241 tgtccgccag caccgtgtcc ttctgggcac gcagcacgtc gtcgaccttc ttgtcgatgg
     9301 cggcaaggta gtcggtgatc tcgtccatgg tctgctgcat ggcaagctgc gccatgagcc
     9361 ccgcggcacc cgccagaagc gtcgggttgg tcaacagcga tccgggcgtt cgcaccagtt
     9421 cgagaaggcc cttgatcttg ccgttctccg tcagtacagc gcgactggcg tccgcatgtg
     9481 agcccttcat cagccggtgc ttcttcagag cctgcgcgga ctgctcggtc aacttcaccc
     9541 agcgccccga ttcggccgcg atcccggaac ccgcctgcgt ggctccggcc atggcaccaa
     9601 gagctgatcc gagccttggc agtccgaggt ccttcgacgg cagtccttcg gagacgagga
     9661 agcgttcgac cgccgccgga ctgccgatga ccgccaagcc ctcgccgtcg ctcatcagct
     9721 gaatgtcgtc atccatcgtc ggctcctgaa aaggctcttc acagctgagg gcatgggcag
     9781 tgtgcggcgc cggccggctg aggggcggcg tcctccgacg acggacggtc tcacaccgcc
     9841 tgtccggaag atctcgacgt gcccgacgct accttcgcct gccctgacct gactacggtg
     9901 cacaacgccc ctggcggccg gcggagttgc gtgagaagac tccatcttga aattgatggc
     9961 gaccgtgccc ctgggccgcg accgggcata aaaggtgcgg tcagtacgtg cgcgtgaggg
    10021 cgcgcagggt tttgcccagt ggtgggctcg cggagccgtg gagtatgccg gtgccccggg
    10081 cgagcacggc tttcgcggtg aggagttcga tctccaccag agcgccggcg aggcatcggc
    10141 cgccgggtga ggccagggtg tggaggggtt tggcggccga caacgaccgc tggacggttg
    10201 cgacttggtc ggctatcagg gccgacaggg gtgaaccgcc gacgccggtt cgcaggtcgt
    10261 ccggagtgac cccgaagcgc tccatcgcct cgaccgggat gccggtgcgt ccctcctcga
    10321 tgtcctcggc gaggtcgttg acgaagtcga ggcgctggct gccctcgatg aaggtccggc
    10381 aggccgcgcg gtacggaagg tcgtcggctt ccggtgcgag cagtccggcg acgagcatga
    10441 aggcggggta cgagtaggcg tccacgtacg cctggtagtc cgcctcggtg gcgaagcccg
    10501 tgcagtgcgg ttcggcggtg gcggtcgcca ggtaggtgtc cacgaggccg cccagtcgcg
    10561 ggtgcgcggc gacggtgtgg gcgagggtgc ggaggagggg gctgtcgctc gtgcccgtcc
    10621 gcagggcgtc gcgcacctgg cgttcccagt ccgcccacgc cgcctcgcgc tgcgggaggg
    10681 ggtcggtgtc caggaggttg tcgccgtggt gcatcacggc ggtcgcggcc atcacgtggg
    10741 gcagcagggg ggcggggcag cggcagcctg gccgcgaggt acgcggtgcg gcggaagcgt
    10801 cgtaccgcac gccgttgacg gtcgtggtcc gcgcgcaacc ccggctcccg gacaccggcg
    10861 gcgtccaggc tcttcgtcca ccctcgcatg ggccgatcgt agggtgcggg cggaccgttc
    10921 tcgaacagcc gtatgtccgc cgcagcggtg cgcccggact cgtgggccgg gcgcaccgct
    10981 gtctcagcgc cggaccgggg ccgggccggt ctcggtcggg tgcggggccg gggcgtcggc
    11041 ggccttgcgc ggggacggga tgaaggaggc gaccgcggcg gagacgaggg cgacgccgca
    11101 gccgatcagc aggccggtgc ggaagccgtc ctccgaggcg atggtgtagc cgcccaggtc
    11161 gatcgtcata tgggccagta cgacgccgat cacggccgag ccgatcgtgg tgcccagcga
    11221 ccgcatcagc gtgttgaagc cgttggccgc cgcggtctcg gagagcggga ccgaactcat
    11281 gatgagcgcg ggcatggagc cgtaggcgag ggcgacaccg ctgttgatga cgatgccgga
    11341 gagcatgatg ccccaggccg tgcccatgag gggcagcgcg agcgcgtagc cggcggccat
    11401 caccacggcg ccgcaggtga gcgcgagctt cgggccgcgc gcgttgatca gctttccgcc
    11461 gagcggcgag atgaccatca tcatgatgcc gccgggggcg atccacaggc ctgccgccag
    11521 catcgactgg cccagaccga atccggtggc cttcgggaac tggagcaact gcggtgcgat
    11581 cagcatgaag gagtacatgc cgacgccgat gaggaccgac gcggcgttgg tgatcagcac
    11641 ccgcggccgg gccgtggtgc gcagatcgat cagcgggtca cgggtgcgca gctcccagaa
    11701 cccccaggcc ggcagggcga cgacggcgac ggcgaacagt acgagcgtgc tgcccgaggc
    11761 ccagccccag tccgcgccct tggagatcgc cagcagcagc gcgaccagcc cgatcgccag
    11821 cccgagcgcg ccgagcgcgt cgaagcgctg gcccttggcg ccggccggga cgtccggtac
    11881 gacgacgaag atcagcacgc cgacgatcac ggcgagggcg gccgaccccc agaacagcag
    11941 ctgccagtcg gcgtactgcg cgaccgcggc ggccagcggc aggccgatcg cgccgccgat
    12001 gcccatcgac gcgctgacca gggcgatgga gccgctgagc ttctcggcgg gcaggacgtc
    12061 ccgcagcagc gcgatgccca gcgggatcat gcccatgccc atgccctgaa ggccgcgtcc
    12121 gacgatcatc ggcacgacgg acgcggacag cgcgcacacc accgagccga tcaccagcgg
    12181 caccacgcag atcagcatca tctgccgctt gcccacgaga tcgccgagcc gcccggacac
    12241 cggcacgcag accccgccga cgagcagggt gaccgtaacc acccaggcgg cgttcgacga
    12301 cgaggtgtgc aggatccggg gcagttcggc gatgagcggg gtcaccaggg tctgcatgat
    12361 cgcggcgacg gttccggcga gcgccagggt ggcgacgaca ccgcccgttc tgcggctcgg
    12421 ctgcggggca tccagctgcg gggcatccat gggtgactcc tcgattcgtc cggtcgtacg
    12481 gtcatccggt ggtctggggc cggtggggcg ggcgggatgt gcatgatgca catcggtcgg
    12541 cgtgcggcgt cggtgtgtat cgcgcacatc gtatgcagta ttcatatcgc atgtgccatg
    12601 catgtcgccc gctcgcctgg agaccttccc cgccgggccc tgagatacgg tcgacttctg
    12661 aaggaggcac gtacatgggg aagccgtcgc acctggtcga gttcgagcac atggtgctcg
    12721 ggcggcatca gctgagcagt accacccgcc ggcaccagga gggccggatg gagcggagcg
    12781 cgtacatcat gctgagccgg atcgaagtgc aggggccgat gacgatcggg cagctcagcg
    12841 acgccttcca gctcgacgtg tccaccgtca accggcagac cgcgcacgcc atgcgggccg
    12901 ggctcctgga gcggatcccc gaccccgagg ggggcatggc ccgcaagttc cggctgaccg
    12961 gggagggcga gcgaaagctg cgcgaggaac gcgcgctgca cgtccaggat ctggaccggg
    13021 tcttcgagga ctggtcggcc gacgacgtgc agaacttcgc ccgctacctc cagcggttca
    13081 acacgagcgt ggaacggatc accggccagc cgtggccgcg gtcgtgagcc cggccgcggc
    13141 gtcccggccc cgtcgaagcg ggaccaccga gcggcggccg ggtccgtgtc gaaggcgcgc
    13201 atccggcgca gcgggaagcg cagcaggacc agcggggtcg ccgacagggc ggccgtcagg
    13261 aaccacaacg ccccccgtac acccgccact tggccgagcc cgcccgcgag cagaccgctg
    13321 agcgggagga cgccccagac cgggaaacgc atcgtggcgg tcatccggcc cggcagatgc
    13381 ggccgtcggc cgaaccctag tggcccgccg cagcggccct ccggtcgttg cgcagttccg
    13441 tcgccagttg ggtgaccgcc gtgtacagcg ggttcgccgg gtcgacgccc cagcggtgca
    13501 ggtagacgag gagctgggtg acgacggtgt cgtactccac cagggtggag ctgttcggag
    13561 cgctcagctt ctcgatctgc atcaggcgtt gataggtcgc gtcatcgagc ttgcccttga
    13621 agagcatcgc gtagcgggcg acgcccttgg ccgggtccgt ggcgtacgtc agcttggacc
    13681 tgaagaggtt cttctgatcc tcggtgagcg tcccgtcgct gtccaggagc gcttgcaggg
    13741 tgtcgacccg gcccttgcgc tgcgtggcca gcgccgtgat ctcggcgtcg gcgaggttct
    13801 gccgcaacag cagcaggatc tgcgtgttgc cgaagctctc gccggcgtcc acgtgcgtga
    13861 gttcgtgggc gagcgagccc agccgctcgg tcgcgccgtc cccctgcacc atcatgtgct
    13921 tgagggtgta cttctcggcg acacccggtt cggacagctt cgtgcccggc atgccggtcg
    13981 tgaagttgac gatgccgcgg ttggccagca ggtcgccgag ggtgtcccgg gtgacctgcg
    14041 gggcgttggg gtccgtccgg atctggtcca gcaactggag atcgtccccg acgagggtgc
    14101 tcttctccgc gtccgtcagc gcgttgacgg cttggagcag cgggttatgg agatggacgt
    14161 tggccatgga cacttcgctg ttgatgtcca ggtgcgcggt ccggacgcgc tgcaggaccg
    14221 cctcctgcgc ggtgaggagc gcgcgtgcct tcggcagagg ggccgccagc ccgacggcgt
    14281 tcgcgagctg ccggaagatc gcggcctcgg gctggcagtc gtcgagcagg tcctgcacca
    14341 cctgcgcgtg ccgtcccgat ttcgagtgcg cgaggtagtt ctgggcggcc tggacgaggt
    14401 tgtccagctg atcggcgcgg cccgcgaagt tgtcgggccg tgccgtgggc ccatggcagg
    14461 tggtgagggc ctgctcgacc gcgacgatgg atccgccgcg cttctgcaag gggccgacgg
    14521 tggtgctccc ttggaactcg gcgaccgaca tcagccgggc gacggccagc cccgcgccgg
    14581 cgtgcgccgc cgcgaccggc gcccggcccg aaccgtccgc caccgctccg gccgccccgc
    14641 cgtccaccgc tccggccgcc gccccgtcgg ccgtcacccg ccgcgcgacc cgctccgcct
    14701 cccgctcgaa ccggtccgac ggatcgctga cggcgagccc gcccccggtg tccgtcccgg
    14761 cgaccggacc gcgccgctgc tgcacgacat gcgtcagctc atgggcgagc acggtgcggc
    14821 ccgcctcgga cgaggggtcg tagcggtcct tgcggaagac gatgtgcgcg ccggaggtgt
    14881 acgcctcggc ggacacggag gccgcggact cgtgcgcagc ccggtcggtg tgcacccgta
    14941 catcggagaa gtccgcgccc agccgggcct ccatgtcgcc gcgcaccgag tcgtccaggg
    15001 gccggccggg ggagcgcagc accccgcgca ccgcggccga ctgctgttcg gccgcctcgg
    15061 accgctccgc cccggcgcgc tccagcatct cgccgaccgc cgcgttgccg atcagccgtt
    15121 gcagcgaggc catcgcgtcc ggcggtggcg cgcccgcctg cccgggccgc tgggcgcccg
    15181 ccgctcgcgc cgtggtggac cgggggcgcg agccctttgg cgtgggatcc tcgtgtcgct
    15241 tccggtgctc gtgcacaact ctcctcacca cgccgagtcc tgccccaccc ttcgggtgta
    15301 cgacacgcat gccccgcccg gacagggcgg gccgggcaac atacgggcag agccgctgcc
    15361 cgagcggtca ccggtgacgc cgagggggaa accgctccag ggcggggacg gtcaggtggt
    15421 gcgcagcggc accggcagat ggtccccgag gtggacgtgg gacagccgtc agcggccgcc
    15481 ggaccagtcg agcgccggtg atcccgcagt ggtagagcct gaggcggaag gcgtcggact
    15541 ccgcgaccgc ccggacggcc gtgccgatcg cgacgacctc ggcacatggg caccatggag
    15601 cggcccgagg agttcctcca gaaggcccgc gccttcctcg cggaggcggc acggtgaccg
    15661 gactcctcac ccccgcgcac tcacgcaggc ggaaccggct tccgtcaccg ccgagttgga
    15721 cgccgtgccc gtacccttcc ggttcgccct gtcggccgcg cggctgccca cggcgacgtt
    15781 cggaccgcgg agctggtgcc cggcgccgaa ctcctgctgc tccccgacat gggccacgac
    15841 cgcccccgcg agctgtggcc cacgcccacc gacgccctgg tcgtccacac cggctgagcg
    15901 cgcacgggca cggccacggt ggcagccctc accgtccgtt acggacgtga tcgcccggac
    15961 acgttccggt ccgccgcgtc gaccacccgg aaccgttcgg ccacgatcag cgcgtcgtcg
    16021 tccacgacgg gtgtgtggcc gagcagttcg gtcacctgcg caccgcggaa gaaatcgcgg
    16081 tgggcggcgg cccactcccg cgcgttcgcg tagccgcggc cctcgtccag cgcgaaccgg
    16141 tcgtccacct cgccgaacgg gatcacccgg gcctcggtca gttcgatcac gacggccgta
    16201 cggtcgtccg agtcgagcac cgcgtaccgc tggccggcct cggggagggg ctgccccatc
    16261 cgctccagga tctcgaccag cgccgtcatg gccgtcttgc ggccgctgat gatggcctcg
    16321 accccgctgt cgcgctcagg gccgggaaag gcgagggcga gcttggggag atcgtcagca
    16381 ctcatgcggc cgagcgtact cgacggaata tccgaactcg cccgtatagc agcggagttg
    16441 caccggaagg cggaacgcgg aacgccggtc cgtccgaccc gcggcggggg gtcggacgga
    16501 ccggcgtgga tgcgctcacc cggtccggat cggtcccgga ctacttggtg aaggcgccgg
    16561 tcccgttcgg ggtgccgaga cccgtcgggc cgtcgtaccc cttgcccgcc tggcacaggt
    16621 aggcgacgtc gcaggacccg ttcgaaccgc tggtcacgtc gttcagctgg tccgggtggg
    16681 agtacgggta cgacgccggg gtgtcgcccg agcccggggc gcccgcgagg gcgtagacgc
    16741 cggcgatgaa cggcgcggcg gcgctggtgc cgccgtacac gttccagccg ctggcctggt
    16801 aggtgtcgta gacggcgaga ccggtggccg ggtcggccac ggacgcgacg tcggcgaccg
    16861 cgcgcttggc gcagtcggtg tccttctgcc aggacggctt ggcctcgtac tgcgagcagc
    16921 cggagcccgc gccgtcgccg ccggccgagg tgccccagac ggtctcggag tagccgcggc
    16981 tgctgctgtc cttcttcagc gaggtgccgc cgaccgccgt cacgtactgc gaggccgccg
    17041 ggtactcgac gccgtagccg ctgtcaccgg agctgacggt gatggcgacg ccggggtgct
    17101 tgaagtactg gtcgtccgcg gtggtgtcgt cggacccctc gctgccgccg tagctgttgg
    17161 acacgaactt ggcgccctgc ttcacggcct ggttcacggc cgcgcccagg tcgtccatgt
    17221 tcgccgactt ggcctcgacc agcaggatgt tgcactgcgg gcaggccgcg ctgaccatgt
    17281 cgacgtcgag ggaaatctcc ccggcccaac ccgcgtccgg cgtcgggtag ttggagccgc
    17341 cgtcctggtc gatcttcttg aagcagccgt tgtccgtgct gcactcgggg aggttgtact
    17401 gggagcggta ggccgccagg tccttctcgg cgttcgggtc gtcgttggcg tcgacgatcg
    17461 cgaccgtctg acccttgccg ccgtccttcg ggaggttgta ggcggcggcc aggtcggacg
    17521 gcccgaaacc ctgcggggtg tcgttgcggc cgagggactt gtgctgggcg atgtcggtgc
    17581 gctcgaccga ctggcaggcc atgtaaccgg gcttgctcgg ctgcgaacac agccggtgcg
    17641 tgtgcaccga ggtggccgcg gaggtggtcg ccgcgtgcga ggcggcaggg gtggtggcga
    17701 aggccgacgt ctgcgtggcg acggccacac cgccggtgat cagagccgcc gcggacagca
    17761 gggcgggggc gctgcggcgt atgccggtcc ttctgcggtg ggaatgcaaa aaactgccct
    17821 ccgtgggggg atggtcgact ccgggcgacg gccgataggc gtgtcaaagg catgacaacc
    17881 caccgttggg ggtggccggc cggagtctgg ttctgggcat gtgaatggat gtgccacccc
    17941 ggtcggtggt ggctggggtt gaggttattg actgtttgcc gttgagaaca agggcagttg
    18001 gtaaaacctt ggcccgggct tccggaccgg ccgatatctt ctgcggccat ggagctggac
    18061 gacgccaccg tcaaccgtct gacgtccctc gggctcgccc gctatgaggc ccggatccat
    18121 ctgtcgctca tccggcgcgg ctcgtgcacg gccgccgagg tggcccgcga ggccgatgtg
    18181 ccgcgccggc gcgtgtacga cgtcctggac gccctggtgc ggcggcagtt ggccgccgca
    18241 cgccccggac gtgtgacgac gtactccgcc gtgtcccccg aactcgccct cgcccggctg
    18301 atgtcggccc agcgggagac cgtcgaccgg ctgggacggg cctcgcggga actggccggt
    18361 ctgccgggcc cgctgcggac ccagggccgg gagcacacgg ccccccccgg actgcatcga
    18421 ggtgctgcgc gacccgaagg cgatcggtga acgttttgcc gatattcggt ttcaggcccg
    18481 tcacgaactc ctcacctttt gcaaaccctc tttgtcgcgc cgcccgggaa cacggcgggc
    18541 atcaccgcag tgcgccgcct ccgtcggagc ggcgcacggt ccgcgcgatc tacctctccg
    18601 acaccctggc cgaccccggg acggccgacc atgtccgccg gttcgcggcg gcgggggagg
    18661 aggtgcggtt cgcccccgcc ctccccctca agctggtcat cgccgatgcc gcactcgtcc
    18721 tgtgcgacct gccggacccg gtggcggggg cgggcaccac gacgaccctg ttcatcgaac
    18781 atcccgcctt ggcggcgtgc ctgcggctgg cgttccacac ggtgtgggcg acggcacggc
    18841 cgggaccgga gtcgtgaact cccgcccagg ggtggggaga tgaatggtgc gggggagtgg
    18901 aggtatgtga agaagcggtg tggtggcgtg cgaaagcggt ggcgggacca ccggctggtg
    18961 atcccgccac cgctcgccct gcccgagctg cccgagctgc ccgaactgcc tggtcagggg
    19021 cgcaggatca gccggatcgg gtcgccggtc ttcttctcaa ggcgttcgac cgcctcggcc
    19081 gcccgcgaca gcgggagttc gccgctgatc gaggcggaga agtccagccg gccgccccgg
    19141 atcagggaca gcaactgcgg cagcgcgacc ggcatgtcgg agccgtagtg gccgaggatc
    19201 tgctgctgga ggtagctgaa acgggtgccg tcggcgacgg tcagcggctg atcggtgagg
    19261 cccacgagaa ccagtcggcc cttgggcgcg agcaccgaca gtgcctgcgc gcggacggcc
    19321 gggaccccgg cgaagtcgaa cgcggcggcg agaccggccc caccggtcgc ctcgcggatc
    19381 cgctcgcgca gcgccgggtc ggccgagtcg agcgccaggt ccgcgccctg ggcgagggcg
    19441 cgctcgcggg cggtgggatt ggggtcgatc gcgacgacgg ggcacgcgcc gacggcccgc
    19501 agcagctgca cggcgtggac gccgagcccg ccgacgcccc agacgccgac cgcctcggcg
    19561 ggccgcacgg cacccgtgac ggtgatcgca ccccaggggg tggagaccgc gtccgggatg
    19621 atcgcgccct ggtcgaaggg gatggcctcg ggcagctcgg tgagggcgtg ctcggaggag
    19681 agcgcgtact cggcccagcc gccgtcgtag tccacgcccc gggtgtacgc gacgccctcg
    19741 cggatctcac cggcgtacag cacgacccgc tgacccgggg tccagcgggt gacgccgggg
    19801 ccggtctcgg cgatggtgcc ggacacctcg tggcccaggg tgaccgtgtc gccgcgcagc
    19861 agcagcgggg tgagggtgcc gtcgatcaga tggacgtccg acaggcagac gcccgcggcc
    19921 tccaccttca ccaggacctg gccgggaccg ggttcgggcc tcgccacttc ctcgatccgc
    19981 agggtgcggc tggggatgtg cagccgggcg gcgagcatct gctccatgaa tggcctcctt
    20041 ggcacggcgg cgacccctgg gaccgcgagc cccttaacgc aagtcgcctt gcgatgaaac
    20101 ctacgcccgc cctcggggta aagcaagtgg ccctgcgtta gggtcggacc atgccgtcgc
    20161 ccgaccagcc ctcgtccgac cggaacgccc cgcccctgcg ccgccgaggg gcccggatgc
    20221 gctccgccgt gctcgccgcg accgtggacg tcctgaccga acacgggctc gcgggcacca
    20281 ccgtcggtgc cgtcgcccgc gccgccggcg tccatgagac ctccgtctac cggcgctggg
    20341 ggacccgcga gaacctgatc ctggaagcgc tgaccgaaca gctcgacgcg gcgatgccgg
    20401 tgccggacac cggacacgtc cacgacgacc tcgccgccta cttcggcgcg ctcgcccggc
    20461 tgctcgcgac ggcgcagggc caggcgctgc tgcggctgag cgtcgaacgc gacgacaccc
    20521 tgccggaccg gcgcctcccc tactggaccg agcgcctcga acgtggcgcg gtcatggtcc
    20581 gccggggtgt cgagcgcggc gaactcgccc cggacacgga ccccggcctc gtcatcgagg
    20641 ccgtcagcgg cgccctcttc acccgcgccc tgatcagcgg cgcccccctc gacgaccgcc
    20701 tcgccacccg cctcgtcacc ctgatcctca cg
//
