LOCUS       NZ_CP047144            28170 bp    DNA     linear   CON 30-JAN-2024
DEFINITION  Streptomyces sp. HF10 chromosome, complete genome.
ACCESSION   NZ_CP047144
VERSION     NZ_CP047144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. HF10
  ORGANISM  Streptomyces sp. HF10
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7814787)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Multiple polyene macrolides produced by antifungal Streptomyces from
            gut of Macrotermes barneyi facilitates the termite-fungus mutualism
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7814787)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-DEC-2019) State Key Laboratory of Microbial
            Technology, Shandong Unversity, 72 Binhai Road, Qingdao, Shandong
            266237, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-NOV-2018
            Assembly Method                   :: SPAdes v. NOV-2018
            Assembly Name                     :: SDU_Sthf_5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 05:29:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 6,988
            Genes (coding)                    :: 6,640
            CDSs (with protein)               :: 6,640
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 356
            CDSs (without protein)            :: 348
            Pseudo Genes (ambiguous residues) :: 0 of 356
            Pseudo Genes (frameshifted)       :: 235 of 356
            Pseudo Genes (incomplete)         :: 154 of 356
            Pseudo Genes (internal stop)      :: 18 of 356
            Pseudo Genes (multiple problems)  :: 53 of 356
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:39:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3259817
            Orig. end                         :: 3287987
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jinfeng Ni.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..28170
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="betalactone"
                     /product="butyrolactone"
                     /region_number="12"
                     /rules="(HMGL-like and AMP-binding)"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..28170
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="betalactone"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..27513
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27513
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:17513](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17513)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            445..1824
                     /locus_tag="GR129_RS14280"
                     /old_locus_tag="GR129_14280"
     CDS             445..1824
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_DAP_Arg_deC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000666.1"
                     /locus_tag="GR129_RS14280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14280"
                     /product="diaminopimelate decarboxylase"
                     /protein_id="WP_159708251.1"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 5.4e-35, bitscore:
                     119.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.3e-11,
                     bitscore: 42.0, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVDHEGEAEARERSGRRDEAVRAAVEQGLLGPDAAVAGLLDTRG
                     IRESAAALRTAFEAVLAPGTPVLHAFAVKASPLVPVLRLLHEEGIGAEVASPGELALAR
                     AAGVPAAHTVLDSPAKTPAELREALALGVAVNADNPQELDRLDALTRSAPTRSPLGIRV
                     NPQIGGGSIGATSTATETSKFGVALRDEGAREWVVAAYARRPWLTRLHAHTGSQGIPLE
                     LLARGVAETYALAEEINARVGRRQIDTLDIGGGLPVNFAGEATEPSYARYARLLAEAVP
                     GLCAGRYGLVTEFGRSLLAKHGTVVARVEYAKRSGGRRIAVTHAGVQVATRTVYAPGAW
                     PLRIAAYDAKGRPKPGPEVVQDVAGPACFSGDLLAEGRALPELEQGDYAAALDTGAYYF
                     AHHYAYNSLARPGIYGFAPDGAGGVAFATVREPQTIAEVVAESGGAHASALTTLRAPGS
                     R"
     misc_feature    1842..1855
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.69"
                     /tool="antismash"
     misc_feature    complement(1898..1911)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     misc_feature    complement(1941..1955)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.94"
                     /tool="antismash"
     gene            2004..2387
                     /locus_tag="GR129_RS14285"
                     /old_locus_tag="GR129_14285"
     CDS             2004..2387
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673138.1"
                     /locus_tag="GR129_RS14285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14285"
                     /product="hypothetical protein"
                     /protein_id="WP_159701993.1"
                     /transl_table=11
                     /translation="MPGIDECLLEAMRLPGARGAALVDWTSGLALGTVGEAPGGDHETA
                     AAEAAELARLAAEHRTFTAQGADRPPVDDVIVSNADSYHLLRFIDTSFDSSVFLHLWLG
                     REEGNLALARIRLGEMAARLVLG"
     gene            2384..3274
                     /locus_tag="GR129_RS14290"
                     /old_locus_tag="GR129_14290"
     CDS             2384..3274
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673139.1"
                     /locus_tag="GR129_RS14290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14290"
                     /product="transcriptional regulator"
                     /protein_id="WP_159701996.1"
                     /transl_table=11
                     /translation="MTMVRTPPPPLPVRDRAAARALSPMLNRLAEERATGVLVREHGTL
                     YLTEGRVVHAESPLAPGLDVLLTAHGTLAAAAWQRAAAAAEGLLHAAELLLESGLLPAG
                     ALELCHLDALYDAGYFALAPSSTPGRFHYDGAPRTGPLPSVPVVALERETLRRRLQLHR
                     LWPDPAADTAPLIRADPLLPRDAGPAPRAPAGPARRTPVAPRQRAVLDRVDGTRTAAHI
                     ARELGRQAFHTLVDVRRLAAAGHLRPLAPAVPVPAAAPPPTAPERARNLPPPLPPVTDP
                     DIALLKRLRDALEAL"
     misc_feature    2648..2650
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2684..2686
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3306..3797
                     /locus_tag="GR129_RS14295"
                     /old_locus_tag="GR129_14295"
     CDS             3306..3797
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673140.1"
                     /locus_tag="GR129_RS14295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14295"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_145489013.1"
                     /transl_table=11
                     /translation="MVSEDALGTVLEELHRLRTRVPQLTGSLAAGVDGLVVAHDTPGVD
                     PDGLAALTAAALGVSVRVSDATGNGGLRELLVRGERGYVATYAAGRSAVLTLLAQDRVN
                     VGRLHLEGRRSGARIGEVLDAAEAEAARNAPARQATAPPPRARATRTPRTTTAPTTTDS
                     "
     gene            3809..4183
                     /locus_tag="GR129_RS14300"
                     /old_locus_tag="GR129_14300"
     CDS             3809..4183
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008417686.1"
                     /locus_tag="GR129_RS14300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14300"
                     /product="hypothetical protein"
                     /protein_id="WP_145489014.1"
                     /transl_table=11
                     /translation="MSNTETALKEALTSIEGATGVALVDYTSGMALGTMGGGTTFDLNV
                     AAAGNTDVIRAKMRTMEMLGIKSEIEDVLITLSDQYHLIRLLKGRGGNGLFLYLVLDST
                     RANLAMARHQLKRIEEELEV"
     gene            complement(4230..4841)
                     /locus_tag="GR129_RS14305"
                     /old_locus_tag="GR129_14305"
     CDS             complement(4230..4841)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018548102.1"
                     /locus_tag="GR129_RS14305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14305"
                     /product="hypothetical protein"
                     /protein_id="WP_236576307.1"
                     /transl_table=11
                     /translation="MARAGRGEGRERGGRGLARVAVVVRAGAAPLWWFGVVAAGVGAVP
                     EGWTGRRIGVLAGAALFIVAAAVVALTRRRRYDALARGAARAGKYDVLQDRAVTVRDWR
                     RGHRWWLVSAWALALGSAFAVPVAGGLLLAGCGTGLWLKAGWLGRRERALESLLWVRVD
                     WLDARGGRPAGKAVKGLRGTGIAAGDAAPGGARRRTAALV"
     gene            complement(4932..5774)
                     /locus_tag="GR129_RS14310"
                     /old_locus_tag="GR129_14310"
     CDS             complement(4932..5774)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566956.1"
                     /locus_tag="GR129_RS14310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14310"
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="WP_186337924.1"
                     /transl_table=11
                     /translation="MSVTDSPANRLQALFEGHRLTPTQRRIAHSMVRRAADVPFLSSVE
                     LAELAGVSQPSVTRFAVALGFDGYPALRRHLREVVPAEPAPENGVHNEYQLAVEAEIEN
                     LRHLADLLADPRPVRQAGRILAASRPLPVLGLRAAASQAYGFAYFAAKVHPDVRLLDEG
                     GTMVQDRIDAAVRAGASALLCFALPRHPREVVDTLAHAQDVGLTVVTVADSAFAPVAKH
                     SDLLLPAAVGTGLAFDTACAPMLLGRVLLEAVCDDLPDAQARLEEFDAKAAARGLFVE"
     misc_feature    5846..5860
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.56"
                     /tool="antismash"
     gene            complement(6061..7269)
                     /locus_tag="GR129_RS14315"
                     /old_locus_tag="GR129_14315"
     CDS             complement(6061..7269)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609630.1"
                     /locus_tag="GR129_RS14315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14315"
                     /product="MFS transporter"
                     /protein_id="WP_159701999.1"
                     /transl_table=11
                     /translation="MSTSQTELPSASAPAADNRKLPLSPLLALATAAFMGILTEALPAG
                     VLPEMARDLSVSESAMGQALTVYALATGVAAIPLSVATGAWRRKKLLLLAVAVIAVANL
                     VTALSASYPLTMAFRLLAGVAAAAVWAELVGYARRLAPPHLQGRAIAITMAGVPLALSL
                     GIPLGTFLGGLFGWRLTFGLVTLISVALLGWITASVPDAPGQRPGVREPILKALSLPGV
                     VAVLFVVAAYVLAHNILYTYIATFLDAYHMGGSRDIVLLVFGIASVVSIWITGALVDRK
                     LRQLTIVSSALFLVAAVLLGVLAGNVVVLYAAMVLWGLGWGGVTTLLQTAVTDAGGDRG
                     QALLVTTWNSFMAGGGAAGGILLDALGPKSFPWSVLALMAPVLVVVLAARKHAFPSTRP
                     GAQ"
     gene            7332..7706
                     /locus_tag="GR129_RS14320"
                     /old_locus_tag="GR129_14320"
     CDS             7332..7706
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645564.1"
                     /locus_tag="GR129_RS14320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14320"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_159702002.1"
                     /transl_table=11
                     /translation="MRIGELSERTGTPRRLLRYYEEQGLLVAGRAPNGYRDYPEGCVNR
                     VLQIRGLLDSGLPTRIIKQILPCINDPRAIHVSDATPETIAALETERQRMTDRIECLLR
                     SREAISGYLDAVRAESPVAA"
     gene            complement(7664..8581)
                     /locus_tag="GR129_RS14325"
                     /old_locus_tag="GR129_14325"
     CDS             complement(7664..8581)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947779.1"
                     /locus_tag="GR129_RS14325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14325"
                     /product="fumarylacetoacetate (FAA) hydrolase"
                     /protein_id="WP_145489018.1"
                     /transl_table=11
                     /translation="MSILFECEYKGQRYAGTGIPVPGEPHVLYRVSEDQVRAAVIAGAG
                     PEALLAAVTEGAETVEVTTGDPELRFLPPLLPTSTNNSLVNGFMGTHRSKFDHDPAPDQ
                     EFTPPNYYLKGFGSWLRMPDEPLVTPADPVWLIEEPEIALVHVNDDDGVPHYAGYTFGN
                     DFNDIGLHLKNPWAWTPYAKLCETSLTPWLFLGEPPRTVTGRVTIERDGAPAWEGDFSC
                     GADSLYHRVEDMTRYVLSYPHLRRPGLVNYLLLGADKATYHDGFRIEDGDRMVIDVASH
                     GVVLANPVQYGQAATGDSARTASR"
     gene            complement(8650..9936)
                     /locus_tag="GR129_RS14330"
                     /old_locus_tag="GR129_14330"
     CDS             complement(8650..9936)
                     /NRPS_PKS="Domain: Aminotran_1_2 (48-380). E-value:
                     4.2e-45. Score: 146.3. Matches aSDomain:
                     nrpspksdomains_GR129_RS14330_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379931.1"
                     /locus_tag="GR129_RS14330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14330"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_236576309.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.8e-43, bitscore:
                     146.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASVPVTMSATLAADEALARRRRAGEEVLSLAGGEIGLPVLTGL
                     RERLGAAADRNAYGPVAGSAALRSAAAGYWGRRGLAADPALVVCGPGSKPLLFALLLAV
                     GGDVVVPVPGWVSYAAQARLAGARPIPVATLPGEGGVPDPAALREAVVLARAAGRDPRC
                     VVVTLPDNPTGTVATPGTVERLARAARELDLVVVSDEIYRDLVFDPARPAVSPAAFAPE
                     RTVVTTGLTKNLALGGWRLGVARLPEGPLGREVHTRLVGIASQIWSSTAAPVQAAAAWA
                     FAEPPEVVAYMAAARRLHEKVVRAAAERFTAAGAALAPVRATCYLYPDFHPLRDRLAAV
                     HDVRGGDALAALLADRYGVGLLPGTAFGESAHCLRLRVATSRLYGETDAERLAALDAPE
                     PTRLPWIRAALDRVTDVLTDLTAPDRPTP"
     aSDomain        complement(8797..9792)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GR129_RS14330_Aminotran_1_2.1"
                     /evalue="4.20E-45"
                     /label="GR129_RS14330_Aminotran_1_2.1"
                     /locus_tag="GR129_RS14330"
                     /protein_end="380"
                     /protein_start="48"
                     /score="146.3"
                     /tool="antismash"
                     /translation="LGAAADRNAYGPVAGSAALRSAAAGYWGRRGLAADPALVVCGPGS
                     KPLLFALLLAVGGDVVVPVPGWVSYAAQARLAGARPIPVATLPGEGGVPDPAALREAVV
                     LARAAGRDPRCVVVTLPDNPTGTVATPGTVERLARAARELDLVVVSDEIYRDLVFDPAR
                     PAVSPAAFAPERTVVTTGLTKNLALGGWRLGVARLPEGPLGREVHTRLVGIASQIWSST
                     AAPVQAAAAWAFAEPPEVVAYMAAARRLHEKVVRAAAERFTAAGAALAPVRATCYLYPD
                     FHPLRDRLAAVHDVRGGDALAALLADRYGVGLLPGTAFGESAHCLRLRVAT"
     gene            complement(10001..11656)
                     /locus_tag="GR129_RS14335"
                     /old_locus_tag="GR129_14335"
     CDS             complement(10001..11656)
                     /NRPS_PKS="Domain: AMP-binding (36-452). E-value: 2.3e-81.
                     Score: 265.4. Matches aSDomain:
                     nrpspksdomains_GR129_RS14335_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609641.1"
                     /locus_tag="GR129_RS14335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14335"
                     /product="AMP-binding protein"
                     /protein_id="WP_159702005.1"
                     /sec_met_domain="AMP-binding (E-value: 6.2e-83, bitscore:
                     277.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTTTAILATASAADRMAEYRRRGWWRDETFLDDLRRQARERPR
                     KPVIAGRRLAEARTDTLDYAELARLTDRFAGALLELDVRRGDVVAVQLPNRWEMVPLMF
                     ACMAVGAVICPIAPVCQEDELRHRLALTEAKVCVTVPQWEGYPLAETVTALKGELPLDH
                     VLVVDGHAPEGALDFHDHFVATHWEKQRSADLEGRQLRPDEPFVVLFTSGTTGFSKGVV
                     HSQNTVHSGVRGYVDTFLLRDDLVVVVTTPLVHYSGFGQGILAGVMLGGTIAFQDGPDH
                     AGLLDLVERYGGTLLYGPPPTLSGVARAQRIDPHDVSSLRHTVTGAAPVLQPLVDELRQ
                     TFGARTYSVWGMSEFGPVTISRLDYNQDWAAHSHGRPIDSMEIRISLCHDLTQRATVGR
                     LQVRGASRALGYYKQQDVFDAELSEDGWFDTGDVAREDGRGGIRILGRAKDTILRDGTV
                     VPMAELEAIISRHPKVAEAALVGPNGTVDDPILAVVVPRRGTTVTLEEIRSYLREAEQD
                     PRFYPERLETVTALPKTLTGKVRKVALRERFAGV"
     aSDomain        complement(10301..11548)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GR129_RS14335_AMP-binding.1"
                     /evalue="2.30E-81"
                     /label="GR129_RS14335_AMP-binding.1"
                     /locus_tag="GR129_RS14335"
                     /protein_end="452"
                     /protein_start="36"
                     /score="265.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RRQARERPRKPVIAGRRLAEARTDTLDYAELARLTDRFAGALLEL
                     DVRRGDVVAVQLPNRWEMVPLMFACMAVGAVICPIAPVCQEDELRHRLALTEAKVCVTV
                     PQWEGYPLAETVTALKGELPLDHVLVVDGHAPEGALDFHDHFVATHWEKQRSADLEGRQ
                     LRPDEPFVVLFTSGTTGFSKGVVHSQNTVHSGVRGYVDTFLLRDDLVVVVTTPLVHYSG
                     FGQGILAGVMLGGTIAFQDGPDHAGLLDLVERYGGTLLYGPPPTLSGVARAQRIDPHDV
                     SSLRHTVTGAAPVLQPLVDELRQTFGARTYSVWGMSEFGPVTISRLDYNQDWAAHSHGR
                     PIDSMEIRISLCHDLTQRATVGRLQVRGASRALGYYKQQDVFDAELSEDGWFDTGDVAR
                     EDGRGGIRILGRAKDTI"
     CDS_motif       complement(10985..11035)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GR129_RS14335_0001"
                     /evalue="1.40E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="GR129_RS14335"
                     /protein_end="224"
                     /protein_start="207"
                     /score="17.8"
                     /tool="antismash"
                     /translation="VLFTSGTTGFSKGVVHS"
     misc_feature    complement(11282..11284)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11653..12768)
                     /locus_tag="GR129_RS14340"
                     /old_locus_tag="GR129_14340"
     CDS             complement(11653..12768)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967620.1"
                     /locus_tag="GR129_RS14340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14340"
                     /product="Glu/Leu/Phe/Val dehydrogenase dimerization
                     domain-containing protein"
                     /protein_id="WP_145489020.1"
                     /transl_table=11
                     /translation="MSELENPQPAFTVRLNGSGGTLRGWVVVDSLYDGLAMGGVRMTTG
                     VTEEEVAGLARDMTHKFILAGLPIGGAKGGIVADGTDREETFRTFGRTVKPLLHGGIHL
                     GIDMGVTPADRAVFFEQAGYDPRYRLGAPDMPIDWRTYYEPLIDCTGHGVGVAAVTALE
                     ASGRTGPARVVVQGFGAVGRAVARFLEDRGHVIVGVADVEGTISADRLPVAELLSVTDE
                     FGLIDRSRLPQGVTVSAEPDAWLDVDADLLVLAAQKHALNDGNAHRLRAALVVEGANLA
                     SSAEAREKTRASGATLVPGVIANIGGAGSAALAVTRVVPFGLPADARKAWVFDWIGDRV
                     RRNTRDLLEIAAATAGDPLPELLKTRREERG"
     gene            complement(12822..13400)
                     /locus_tag="GR129_RS14345"
                     /old_locus_tag="GR129_14345"
     CDS             complement(12822..13400)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609639.1"
                     /locus_tag="GR129_RS14345"
                     /note="Members of this family of hydrolases with an active
                     site Cys residue belong to MEROPS family C26.; Members of
                     this family of hydrolases with an active site Cys residue
                     belong to MEROPS family C26.; Members of this family of
                     hydrolases with an active site Cys residue belong to MEROPS
                     family C26; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14345"
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="WP_236576311.1"
                     /transl_table=11
                     /translation="MRSKRVAQSRVLVVNNGTLSLKQLRKRFEELGSDTDAVDAASVPD
                     RLGGRYQAIVLSGTKVRAYDRDHYRPLVDLVMTADVPVFGICGGMQILAVAAGGRLAEG
                     PQRVGGYEVRVDKEEPLFTHVKPTVTVFHRHTLYLREAPAGFRSIGRSEHAPVEFLRSD
                     DGRILGSQAHLEFRGDGLEILRGFAELYQ"
     gene            complement(13397..14206)
                     /locus_tag="GR129_RS14350"
                     /old_locus_tag="GR129_14350"
     CDS             complement(13397..14206)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947774.1"
                     /locus_tag="GR129_RS14350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14350"
                     /product="acetylglutamate kinase"
                     /protein_id="WP_159702008.1"
                     /transl_table=11
                     /translation="MSAPETASEATPTVVKLGGSCLDDLAGAWWDDLARHAEARPLILV
                     HGWSKPLKRLSARYREPSAILRDRYGNQSRWTTPEVIEDIKAVSAELGETVLGRLEQRG
                     ITAERLLASDGLVSAGEGERWWWRDKQLVKLENLVGPITGVDPTALKNLQPGHACLITP
                     LARNAAGQEVNTDADRAAAAIAGAAEATDLVLVTDVEHLLIDGEPVRRITARAAAEFRD
                     KGATGGMRKKLRAAGEALEAGVARVVIGSAPVTDLLAARTGTVITRP"
     gene            complement(14203..15261)
                     /gene="argC"
                     /locus_tag="GR129_RS14355"
                     /old_locus_tag="GR129_14355"
     CDS             complement(14203..15261)
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379927.1"
                     /locus_tag="GR129_RS14355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14355"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_159702011.1"
                     /transl_table=11
                     /translation="MIRVGIVGASGLAGGELIRLVSQHPELELAFLGGDSSAGRTPAQL
                     HPGLRLDLGLVVERVTADALAERCDVVFLATPAPVSAELAALLADRVPCVIDLSGAFRI
                     RDPRRHERWYPKATRSAGLADRFVYGVPELVGDQLAGAPLISVPGCYATAITLGLAPLT
                     LGLGLNLRTVVVDGKSGSSGGGLQLRVPDLHPLRNGAIAPYAPTGHRHAAEVSDFLERG
                     KPGTVGSLTMSAYGVSHVRGLLASVYAFTDDQVDGRELQRAYLRFYKGQRFVRVRRNTE
                     TLIPVPDPQAVLGSNFCDVSVLYDDEGGRIVVLAALDNLVKGAAGQALQAMNKRFALPE
                     ETGLTMQPVMPA"
     gene            complement(15258..>16052)
                     /locus_tag="GR129_RS14360"
                     /old_locus_tag="GR129_14360"
                     /pseudo=""
     CDS             complement(15258..>16052)
                     /GO_function="GO:0016881 - acid-amino acid ligase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR00768.1"
                     /locus_tag="GR129_RS14360"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14360"
                     /product="RimK family alpha-L-glutamate ligase"
                     /pseudo=""
                     /sec_met_domain="ATP-grasp_3 (E-value: 5e-09, bitscore:
                     35.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 4.3e-25, bitscore: 87.1,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 6.7e-08, bitscore:
                     30.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LIRRAPDLGLRIDWINDESLCLGESGTSSIEGYDALLVRSRSYTR
                     GGLLATLAESSGVPVLNSATAIHACENKLVLRALLRAAGVPVPEFRLALSRKDFTRALD
                     DLGLPVVLKPVYGGMGKRVTLVRDADLAQSVYDYVEDLGHAFEQACLVEPYLGGGSVRC
                     LVVGREIVAAAEFESAGADWRSNAALGNQSRALTHDPEVQKLVDGVVDQLGDGIYGVDL
                     FRTPTGHLVNEVNHAPAWRGVAAVTGADIPAAIARHLQEIFA"
     gene            complement(16107..16292)
                     /locus_tag="GR129_RS14365"
                     /old_locus_tag="GR129_14365"
     CDS             complement(16107..16292)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967615.1"
                     /locus_tag="GR129_RS14365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14365"
                     /product="lysine biosynthesis protein LysW"
                     /protein_id="WP_145489024.1"
                     /transl_table=11
                     /translation="MSTATLTGDCPECETDLTVPPMVRGETLSCPECMLTLRVEEIRDG
                     RLSLQMVEVQLRDWGQ"
     misc_feature    complement(16285..16300)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.13"
                     /tool="antismash"
     gene            complement(16362..17513)
                     /locus_tag="GR129_RS14370"
                     /old_locus_tag="GR129_14370"
     CDS             complement(16362..17513)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967613.1"
                     /locus_tag="GR129_RS14370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14370"
                     /product="isopropylmalate synthase"
                     /protein_id="WP_159702014.1"
                     /sec_met_domain="HMGL-like (E-value: 3e-48, bitscore:
                     163.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGEEHGGSLPRPPRLSDATLRDSAHMAGVEFGPKDAAVIADLLV
                     KTGIELVEVGMVSGPGSKDADLVLATHEAVGPERSMTLVVVRDRRQVAQALDEAERLGV
                     RHIMYSIPTSEQHAQLKLGSSSAKFLHTLARSAISQAKERGFHVTFSGEDGARTPEERL
                     VPYVTAGFEAGADRFRLAETVAYLSPWQMEAVIGNLTAIDGSEIEIHSHNMLGMAVANS
                     LAAVRAGAQWISATVGGIGERGGNAPLAELLTSLRVIHDDTRFDLSHLTELSRVALRGA
                     GLGDAFQSGPTTPHAFAYELPGQLTHPEAYETLPAELVGNARGLRVRTRLTTALVAWAL
                     ADSGVSVDLDAFTPWLTERQERDGSPLLDRDTIRKAAVDFQAA"
     cand_cluster    17241..28170
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    17241..28170
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[22240:23170](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      22241..23170
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     misc_feature    17521..17535
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.11"
                     /tool="antismash"
     misc_feature    complement(17562..17578)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.53"
                     /tool="antismash"
     misc_feature    17584..17601
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    17653..17669
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.3"
                     /tool="antismash"
     misc_feature    17679..17692
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.35"
                     /tool="antismash"
     gene            17746..18894
                     /locus_tag="GR129_RS14375"
                     /old_locus_tag="GR129_14375"
     CDS             17746..18894
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="GR129_RS14375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14375"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_159702017.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-14, bitscore:
                     53.0, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.6e-21, bitscore:
                     75.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIPPFPTGAWARELAGRVAAPTTADRDRERRWDPRLFAELAGAG
                     PAGPGLTGALVPRDLGGAGLSAAQTLDLLAGLGEGARDPGLALAVGVHAVLATVPLRAF
                     GSPSQRERYLPRMASGEWVGALSLHQTQGASVTPAVSARPAPDGSGRWLLTGALDLVAG
                     APVAHHFLVVAAHGDGGRTAFVVDRSTPRLGVGEAGPDAMPTCPWGRLVLEDCAVPDTA
                     VLGGVGGAAREVEPLLAALDWVFSSAPWLGLLRALTRDAVDGARERRLFGRPLHHDQSV
                     RFTLADLAARCELADGMLRRAAEQFDSGARPAHRDAAAARLFVAAAVRTVTDAAARLSG
                     PLGLTGDHLTGRAHRDGLFFAGTGGGTEVLRPVIAASLLELG"
     gene            18924..20288
                     /locus_tag="GR129_RS14380"
                     /old_locus_tag="GR129_14380"
     CDS             18924..20288
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="GR129_RS14380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14380"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_159702020.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.1e-13, bitscore:
                     49.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.9e-15, bitscore:
                     53.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.8e-29, bitscore:
                     101.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTTSMYDPTGAPAFAGTPATEAASASEGNPATETAPASEGSPT
                     SEGSPAFDGTAAFEGIAARAAETDATGRIPARNWKDLADSGYLRLFHPPEVGGSGADAR
                     TQADAMEALARACPGTYWAATVSALLCGKLITTYGDLRSHEPLLRSLLSGEKLAAFAVV
                     ERTAGSDAGTFRTTVRRAGAPGGGFVIDGEKSRITNAPVADVAIVLARRERLPGDDGPD
                     WCLAFVDLHQAGVERYGIAHMGLRGMPWGGMVFTDARVAEADVLPVPFEELAEGMAWGW
                     LKNSFAAIAVAESALAASVRHARERVSFGRPLAHMEGVQAQLAESRAQIDAARLLARRA
                     MGERAAGRSARDLIAMLKIYATEMGVEVAARAVQIHGATGVTQGHEVERLYRDAQMNVI
                     GGFTSNRLREQVAEGLGLGPAVYSAFDWVAPAGLGQDPAGLDGPPHPEETARQKP"
     gene            complement(20379..21068)
                     /locus_tag="GR129_RS14385"
                     /old_locus_tag="GR129_14385"
     CDS             complement(20379..21068)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379923.1"
                     /locus_tag="GR129_RS14385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14385"
                     /product="response regulator transcription factor"
                     /protein_id="WP_159702023.1"
                     /transl_table=11
                     /translation="MAGHAAQPDTTRVLVVGDDVGGAEARVRGLRRQGFQARSVDTGAE
                     ALSAHQQADLVLLDLDLPDIDGLEVCRSIREAGDKPIISVTARDTELDRVLALQAGADD
                     CVVTSCGEREMLARIEAVLRRARPRSERSRPLSLGPLCIDSRTREVRLDGRPLNVTAKE
                     FELLRTLAATPESVISRKELMARVWETTWADSSRTIDTHVRSLRAKLGAHSWIITVRGV
                     GYRMGHG"
     misc_feature    complement(20571..20573)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21103..21116)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.03"
                     /tool="antismash"
     misc_feature    complement(21109..21118)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     misc_feature    21113..21126
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     misc_feature    21126..21135
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     gene            complement(21476..22129)
                     /locus_tag="GR129_RS14390"
                     /old_locus_tag="GR129_14390"
     CDS             complement(21476..22129)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988493.1"
                     /locus_tag="GR129_RS14390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14390"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_145489029.1"
                     /transl_table=11
                     /translation="MVRQDRAIRTRKLILENMASLFNEVGYDAATIAALVERTGLTRGA
                     LYFHFASKEDMARAVLDEAVTTEGLSPQSFKLQEWVDLGLLLAHRLPREPVLHAAIRLA
                     VDPKARRLFGTRWPDWVALGRELLTEAKESGELLAHADPAAVSRVFVGAWTGVQLVTEV
                     LEEKLSLAEEIAGLYQLLLPSIVTPAVLAKLDLSPYRAERLLRESDEQEAAGHG"
     misc_feature    complement(22093..22108)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 20.25"
                     /tool="antismash"
     misc_feature    complement(22200..22216)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            22241..23170
                     /locus_tag="GR129_RS14395"
                     /old_locus_tag="GR129_14395"
     CDS             22241..23170
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041195.1"
                     /locus_tag="GR129_RS14395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14395"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_145489031.1"
                     /sec_met_domain="AfsA (E-value: 2.2e-17, bitscore: 61.5,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLRTLCDRREALPGAVDVGRPAPRGTGPRPELGEYIHLRHAPA
                     ILVGAWRQEGPDSFTVTARWPGHGGPGAYDPRLLTQTIRQSGLLVAHAEYGVPTGHQAL
                     LSNLDITVRPGFEAPEVSDLDVDIAVTRPERRSLGMEFRIRRDGVTVCLANTKFSWVAP
                     AVYRRVRGPHSTVDWGGWPLPEPVDRGLTGRADDRDVLLAPGTAGHRWRLRADVSNTLL
                     FDHPVDHVPGLVLLEAAYQAAHAAAGPKPLELTDVAIGYERYVEFDEPCWIEAEWLPSL
                     MPDWFAIAVTGHQGGEVAFQAQLRGLRP"
     gene            complement(23247..24011)
                     /locus_tag="GR129_RS14400"
                     /old_locus_tag="GR129_14400"
     CDS             complement(23247..24011)
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (9-171). E-value: 8.5e-15. Score:
                     47.1. Matches aSDomain:
                     nrpspksdomains_GR129_RS14400_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988472.1"
                     /locus_tag="GR129_RS14400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14400"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_159702026.1"
                     /sec_met_domain="adh_short (E-value: 1.5e-34, bitscore:
                     118.2, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.4e-29, bitscore:
                     102.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSELLADKVVLITGASSGIGTAAARVFSGEGATVVLTGRREDRL
                     AALVSELQDRKAEASYVVGDVSVAADAGRAVDLAVARYGRLDGAFNNAGIGGDRTPLHL
                     MTDDVYDTIMDVNVRGVWNCLRHEIAAMLPRGGGAIVNNSSVAGLVAIPAAAPYIASKH
                     AVVGLTRAAADEYAARGIRVNAVAPGTTRSEITVDWFARNPGLEQMVNSLTPQGRTAEP
                     EEIAEAAAWLLSDRCPFLTGTVLPVDGGFANH"
     aSDomain        complement(23499..23984)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GR129_RS14400_PKS_KR.1"
                     /evalue="8.50E-15"
                     /label="GR129_RS14400_PKS_KR.1"
                     /locus_tag="GR129_RS14400"
                     /protein_end="171"
                     /protein_start="9"
                     /score="47.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGASSGIGTAAARVFSGEGATVVLTGRREDRLAALVSELQD
                     RKAEASYVVGDVSVAADAGRAVDLAVARYGRLDGAFNNAGIGGDRTPLHLMTDDVYDTI
                     MDVNVRGVWNCLRHEIAAMLPRGGGAIVNNSSVAGLVAIPAAAPYIASKHAVVGLTRA"
     misc_feature    complement(23856..23858)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(23940..23981)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GR129_RS14400_0001"
                     /evalue="1.70E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="GR129_RS14400"
                     /protein_end="24"
                     /protein_start="10"
                     /score="11.2"
                     /tool="antismash"
                     /translation="VLITGASSGIGTAA"
     misc_feature    24126..24139
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.03"
                     /tool="antismash"
     gene            24192..24845
                     /locus_tag="GR129_RS14405"
                     /old_locus_tag="GR129_14405"
     CDS             24192..24845
                     /GO_function="GO:0004089 - carbonate dehydratase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019066701.1"
                     /locus_tag="GR129_RS14405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14405"
                     /product="carbonic anhydrase"
                     /protein_id="WP_159702029.1"
                     /transl_table=11
                     /translation="MATPHRALRTPTAPAPRPPCPPFPALVPPPEADEPRPTAAAVLDE
                     LLAGNARSTGGLARQPYVRPTGRRPCAVVIGCVDAPVPPELVLDQPLGELLCVRTAGLV
                     LDEAVLGSVQYGVQELGAPLVLVLGHERCAAVAATLERLRTGAPVPGHLELLVEEIAPA
                     ARRTRNRPGDWAEHTVRAQTTWVRDAIRADPAFGAARVVAARVDDGTGLVSLLP"
     misc_feature    24213..24215
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            24977..25423
                     /locus_tag="GR129_RS14410"
                     /old_locus_tag="GR129_14410"
     CDS             24977..25423
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673145.1"
                     /locus_tag="GR129_RS14410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14410"
                     /product="hypothetical protein"
                     /protein_id="WP_145489036.1"
                     /transl_table=11
                     /translation="MSARDPQDVGLKGDAELRKDLDATVRARRDLGEEYDSALVESFLE
                     KVEQRLDGAVDRRVRRQVAEQQMAAARGTAGRRNPVDSWGERYGFALLTLVLAIPLSAI
                     AGAGAGLAGMVVTWLGIVGVNAAQVIRVHPQLLSGRSRRSGRDV"
     gene            complement(25991..27133)
                     /gene="tgmC"
                     /locus_tag="GR129_RS14420"
                     /old_locus_tag="GR129_14420"
     CDS             complement(25991..27133)
                     /codon_start=1
                     /gene="tgmC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018101304.1"
                     /locus_tag="GR129_RS14420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14420"
                     /product="ATP-grasp peptide maturase system
                     methyltransferase"
                     /protein_id="WP_159702035.1"
                     /sec_met_domain="PCMT (E-value: 3.4e-19, bitscore: 68.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTATRLRAALVDRLSEDAPSMEPEWRSAAGAVPRELFTGSYFRP
                     VAGTVPTRYRPVREGEPGWLEGVYSDETLITQLDGRTRPDDATEGTVTGSPSSSSTLPS
                     LVLRMWQQLGVETGHRVLEIGTGTGYSTALGAHRLGDAGLTSVEYDPVVASAAATALKA
                     AGFAPRLIIGDGLRGDPDGGRYDRLIATCSVRYVPLSWLHQVKPGGKILVTLSGWSYAN
                     ALALLEVTGPGEAMGRFLPGCTSFMIARPHDRPPRPTLVLLPGDERPSRIDPARLDDWT
                     GGWVAQLAAPSAERMGAGPEQILWDVSTGSQARTALGPDGEWTVVQRGPVRLWDRVEQA
                     VRRWQAAGEPHQEGFGITVSAAGQRVWLATEDGPGWYLPI"
     gene            complement(27130..28092)
                     /gene="tgmB"
                     /locus_tag="GR129_RS14425"
                     /old_locus_tag="GR129_14425"
     CDS             complement(27130..28092)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tgmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018101305.1"
                     /locus_tag="GR129_RS14425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_14425"
                     /product="ATP-grasp ribosomal peptide maturase"
                     /protein_id="WP_159702038.1"
                     /transl_table=11
                     /translation="MSDSRPVLVLTNPRDVTADLVLRLLVDRRVPVVRLDPGTDLHTGS
                     SLTATYRTSGQGGVLRTASRELDTGRVRSVWVRRPSPYEGPQGLRERDRRFAAEQARWG
                     AGGILASLPGAHYVNHPWRNRAAEFKPAQLSTARRCGFLVPSTLITNDPYEARAFAARQ
                     PGGVVYKPVWNTPYRVDDQPHSVWVREVRGVEITDAVSVCPHLFQARVDKAFDARVTVV
                     GGRLFGVRIDSPDLDWRHRQDLMACTPVDLPESVARAVAVYFAELHLVYGAFDFAVSTT
                     GDWYFLECNPNGQWAWQPAETTAAIARAIADQLEKGPDT"
ORIGIN
        1 gaccaggttg gagttggcga tgaggacgcg cggcgcccac tcgtgggtct gcatcacgcc
       61 gaccgggcgg ccggactgga ccagcatggt ctcgtcctgc ttgagggtgc gcagggtgcg
      121 caccatcgcg tcgaaggagc gccagtcacg ggcggccttg ccggtgccgc cgtagacgac
      181 gagcttgtcg gggtgctcgg ccacctcggg gtcgaggttg ttctggagca tgcgcagggc
      241 ggcttcctgc tgccagccca gggcgctgag ttccgtgccg cgcggtgctc gtacggggcg
      301 gggtcccgac atcgtctgcc tcctgctgtt gctacgtcta ttcacatcct ggctgcatga
      361 atagaactag tcaatacatc ggggcggccc cgtccgcgcg tcccgggtgt ttggctggaa
      421 gcagctgacg tccgacagga gggaatcgcg gtggaccacg agggcgaggc cgaggcgcgg
      481 gagcggtccg ggcgccggga cgaggcggtg cgcgccgccg tggaacaggg cctgctgggg
      541 ccggacgcgg cggtggcggg gctgctcgac acgcggggca tccgggagtc ggcggcggcg
      601 ctgcggacgg cgttcgaggc ggtcctcgcg cccggcaccc cggtgctgca cgcgttcgcg
      661 gtgaaggcgt ccccgctggt gccggtgctg cggctgctgc acgaggaggg catcggcgcc
      721 gaggtggcga gccccggcga gctggcgctg gcgcgcgcgg ccggcgtacc ggcggcgcac
      781 accgtgctgg actcgcccgc caagaccccg gcggagctgc gcgaggcgct ggcgctgggc
      841 gtcgccgtga acgcggacaa cccgcaggag ctggaccgcc tggacgccct gacgaggtcc
      901 gcgccgaccc ggtccccgct cggcatccgg gtcaatccgc agatcggcgg cggcagcatc
      961 ggggcgacct cgacggcgac cgagacctcg aagttcgggg tggcgctgcg cgacgagggg
     1021 gcgcgcgagt gggtcgtggc ggcgtacgcg cggcggccgt ggctgacccg gctgcacgcg
     1081 cacaccggct cgcagggcat tccgctggag ctgctggcgc ggggcgtggc ggagacgtac
     1141 gcgctggcgg aggagatcaa cgcgcgggtc gggcggcggc agatcgacac gctcgacatc
     1201 ggcggcgggc tcccggtgaa cttcgcgggc gaggcgacgg agccgtcgta cgcgcggtac
     1261 gcgcggctgc tggccgaggc ggtgccgggg ctgtgcgcgg ggcggtacgg gctggtgacc
     1321 gagttcgggc ggtcgctgct ggccaagcac ggcacggtgg tggcgcgggt ggagtacgcc
     1381 aagcgctcgg gcgggcggcg gatcgcggtg acgcacgcgg gcgtgcaggt ggcgacgcgg
     1441 acggtgtacg cgccgggggc gtggccgctg cggatcgccg cgtacgacgc caaggggcgg
     1501 ccgaagccgg ggcccgaggt ggtgcaggac gtggcgggcc cggcctgctt ctccggcgac
     1561 ctgctggccg aggggcgcgc gctgccggag ctggagcagg gggactacgc ggcggcgctg
     1621 gacacgggcg cgtactactt cgcgcaccac tacgcctaca actccctcgc ccggcccggg
     1681 atctacggct tcgcgccgga cggcgcgggg ggcgtggcct tcgcgaccgt gcgggagccg
     1741 cagacgatcg cggaggtggt ggcggagtcc gggggcgcgc acgcctcggc gctcaccacc
     1801 ctgcgtgcac ccgggagccg ttgacgcgcc cccgcctcac tcgaacaaat ggtttaactc
     1861 agctgaccca tgggtcagtt gaccaactct agcccgccgg acgcatgttc cactggaaaa
     1921 tgccaaacag ctcacccctc ccccacacgt tgcgtagtgt cgggatcact cagccggagt
     1981 cccagcggga ggggagccac gcggtgcccg gaatcgacga gtgcctgctg gaagcgatgc
     2041 gtttgcccgg tgcccggggt gccgcgctgg tggactggac gagcggcctc gcgctcggca
     2101 cggtcgggga ggcgcccggc ggcgaccacg agacggccgc cgccgaggcc gccgaactgg
     2161 cccggctggc ggccgagcac cgcaccttca cggcccaggg ggcggaccgg ccgccggtgg
     2221 acgacgtgat cgtaagcaac gcggacagct atcacctgct gcgcttcatc gacacgtcct
     2281 tcgacagcag tgtgttcctg catctgtggc tggggcgcga ggagggcaat ctcgcgctcg
     2341 cccggatccg gctcggcgag atggccgcgc gcctggtgct gggatgacca tggtccgtac
     2401 gccaccgccg ccgctgccgg tgcgggacag ggccgccgcc cgcgcgctgt ccccgatgct
     2461 gaaccggctg gccgaggagc gggccaccgg cgtcctggtc cgcgagcacg gcaccctgta
     2521 cctcaccgag ggccgggtgg tgcacgccga gagccccctc gccccgggtc tcgacgtgct
     2581 cctcacggcc cacggcaccc tggccgccgc cgcctggcag cgggccgccg ccgcggccga
     2641 gggcctgtta cacgcggccg aactcctcct ggagtccggc ctgttacccg ccggcgcgct
     2701 ggaactgtgc catctggacg cgctgtacga cgccgggtac ttcgccctgg cacccagcag
     2761 taccccgggc cggttccact acgacggcgc accccgcacc ggcccgctgc cctcggtccc
     2821 ggtggtcgcg ctggaacgcg agaccctgcg ccgccggctg caactgcacc ggctgtggcc
     2881 cgacccggcc gccgacaccg cgcccctgat ccgcgcggac cccctcctcc cccgggacgc
     2941 cgggcccgcg ccccgcgcac cggcgggacc cgcccgccgc acccccgtcg ccccccgcca
     3001 gcgcgccgtc ctggaccgcg tggacggcac ccgtacggcc gcccacatcg cccgggagct
     3061 gggccggcag gcgttccaca ccctggtcga cgtgcgcagg ctggcggcgg ccgggcacct
     3121 tcggcccctg gcgccggccg tgcccgtccc cgcggcggca ccgcccccga ccgcaccgga
     3181 gcgggcccgg aaccttccgc cgccgctgcc cccggtcacc gaccccgaca tcgcgctgct
     3241 gaagaggctc agggatgcgc tggaggccct ttgaacggcc acgccccgcc gagaggagag
     3301 agctgatggt gtccgaggac gcccttggga ccgtcctgga ggagctgcac cggctgcgca
     3361 cccgggtgcc gcagctcacc ggctcgctcg cggccggcgt cgacggactc gtcgtcgccc
     3421 acgacacgcc cggcgtcgac cccgacgggc tcgcggcgct caccgcggcc gcgctcggcg
     3481 tctccgtgcg ggtctccgac gccaccggca acggcggcct gcgggaactg ctggtgcgcg
     3541 gcgagcgcgg ctacgtcgcc acctacgccg ccgggcgcag cgccgtactg accctgctcg
     3601 cgcaggaccg ggtcaacgtc gggcggctcc atctggaggg ccgccgctcc ggcgcccgga
     3661 tcggcgaggt cctggacgcc gccgaggccg aggccgcccg gaacgcgccc gcgcgccagg
     3721 ccaccgcgcc gcccccgcgc gcccgtgcca cgcggacccc gcgcacgacc accgcaccca
     3781 ccacaaccga cagttgagag gacccgagat gtccaacacc gagaccgccc tcaaagaggc
     3841 gctgacctcg atcgagggcg ccaccggcgt cgcgctcgtc gactacacca gcgggatggc
     3901 gctgggcacg atgggcggcg gcacgacctt cgacctgaac gtggccgccg ccggcaacac
     3961 cgatgtgatc cgcgccaaga tgcgcacgat ggagatgctg ggcatcaaga gcgagatcga
     4021 ggacgtcctc atcacgctct ccgaccagta ccacctgatc cgcctgctca aggggcgcgg
     4081 cggcaacggc ctgttcctct acctggtcct ggactccacc cgggccaacc tggcgatggc
     4141 ccgccaccag ctcaagcgga tcgaggagga gctggaggtc taggtcctca ccggccctgg
     4201 gcgacctcac cggcccagga cctcaccggt cagacgaggg ccgcggtacg gcggcgtgcc
     4261 ccgcccgggg ccgcgtcgcc ggccgcgatg cccgtaccgc gcaggccctt gaccgccttg
     4321 cccgccggcc ggccgccgcg cgcgtcgagc cagtcgaccc gtacccagag caggctctcc
     4381 agggcccgtt cgcggcgccc gagccagccg gccttcagcc acagcccggt gccgcacccg
     4441 gccagcagca gtccgccggc caccggcacc gcgaaggcgg agccgagcgc gagggcccag
     4501 gccgacacca gccaccagcg gtgcccgcgg cgccagtcgc gcacggtcac cgcgcggtcc
     4561 tggagcacgt cgtacttgcc cgcgcgggcc gcgccccggg cgagggcgtc gtagcggcgg
     4621 cggcgcgtca gcgccaccac ggccgcggcg acgatgaaga gcgcggcccc ggcgagcacc
     4681 ccgatccggc gcccggtcca tccctcgggc acggcgccga cgcccgcggc gaccaccccg
     4741 aaccaccaca gcggggcggc tcccgcccgt acgacgacgg ccacccgggc cagtccccgg
     4801 ccgccgcgtt ccctgccctc gccacgccct gcgcgcgcca cgtcgccctc ccgtgtcacg
     4861 agtcccgcac tgcctctgtc cggcggggac gctagcgggc gaacctgaga cggacctgag
     4921 aggaccgggg ctcactccac gaacaggccc cgggcggcgg ccttcgcgtc gaactcctcc
     4981 aggcgggcct gcgcgtccgg caggtcgtcg cagaccgcct ccagcagcac ccggcccagc
     5041 agcatcggcg cgcacgcggt gtcgaaggcg agaccggtgc cgacggcggc gggcagcagc
     5101 aggtcggagt gcttggcgac gggcgcgaac gcggagtcgg cgacggtgac gacggtcagg
     5161 ccgacgtcct gggcgtgggc gagggtgtcg accacctcgc gcggatgccg gggcagcgcg
     5221 aagcagagca gggcactggc acccgcgcgg acggccgcgt cgatgcggtc ctggaccatc
     5281 gtgccgccct cgtcgagcag ccggacgtcc gggtggacct tggcggcgaa gtacgcgaag
     5341 ccgtacgcct gggaggcggc ggcgcgcagg ccgagcaccg gcagcgggcg ggaggcggcg
     5401 aggatccggc ccgcctggcg caccgggcgg gggtcggcga gcaggtccgc gagatggcgc
     5461 aggttctcga tctcggcctc gacggcgagc tggtactcgt tgtgcacgcc gttctcgggg
     5521 gccggttcgg cgggcaccac ctcgcgcagg tgccggcgca gcgcggggta gccgtcgaag
     5581 ccgagggcga ccgcgaaccg ggtcaccgac ggctggctga ccccggccag ttcggccagc
     5641 tccacgctgg acaggaaggg tacgtcggcg gcgcgccgca ccatgctgtg cgcgatgcgg
     5701 cgctgggtcg gcgtgagccg gtggccctcg aagagcgcct gcaaccggtt ggccgggctg
     5761 tcggtcacgc tcatcacgta ctccccctcg gttgtcctcg acgccccggg agagtacagc
     5821 gccgaggccg taccgaacac ggaccgatat tcagacaaga tttctctgta taccgttata
     5881 cagcgcgggt gcggtccacc gcaccgtcgc accggccgcg cggcgcggga agaccccgta
     5941 cccgatggag atgggtacgg ggtcttcgtc agcgcctcgc acggccggac ccggcggggg
     6001 atgtcgagat ccggcgtggg tgcgcggcgc gtcctcggag ggctcgcccg gcccggtgcc
     6061 tcactgggct ccggggcggg tcgaggggaa ggcgtgcttg cgggcggcga gcacgacgac
     6121 gagcaccggg gccatgagcg cgaggacgct ccaggggaag gacttggggc ccagcgcgtc
     6181 cagcaggatg ccgcccgccg cgccgccgcc ggccatgaac gagttccagg tggtgaccag
     6241 cagggcctgc ccccggtcgc cgcccgcgtc ggtgaccgcg gtctgcagca gggtggtgac
     6301 gcctccccag cccaggcccc acagcaccat ggccgcgtag agcacgacca cgttgccggc
     6361 cagcaccccc agcaggacgg cggcgaccag gaacagcgcg ctgctgacga tggtcagctg
     6421 gcgcagcttg cggtcgacca gggcgccggt gatccagatg ctcaccacgg acgcgatgcc
     6481 gaagacgagc agcacgatgt cgcgggagcc gcccatgtgg taggcgtcga ggaaggtggc
     6541 gatgtaggtg tagaggatgt tgtgggccag cacataggcc gcgaccacga acaggacggc
     6601 caccacgccc ggcagggaca gcgccttcag gatgggctcg cggacgccgg gccgctgccc
     6661 cggggcgtcc gggaccgacg ccgtgatcca gcccagcagc gccacggaga tcagcgtcac
     6721 gaggccgaag gtcaggcgcc agccgaagag cccgccgagg aaggtgccga gcgggatgcc
     6781 cagcgacagg gcgagcggga cgcccgccat ggtgatggcg atggcccggc cctggaggtg
     6841 cgggggcgcc aggcgccgtg cgtagccgac gagttccgcc cagaccgccg ccgcggcgac
     6901 acccgcgagg agccggaacg ccatcgtcag cgggtagctg gcggagaggg cggtgaccag
     6961 gttggcgacc gcgatcacgg ccacggccag cagcagcagc ttcttgcgcc gccaggcgcc
     7021 ggtggcgacg gacaggggga tggccgcgac gccggtggcg agggcgtaga ccgtcagcgc
     7081 ctggcccatc gcggactcgc tcaccgacag gtcacgggcc atctcgggga gcacgcccgc
     7141 cgggagtgcc tcggtcagaa tccccatgaa ggctgctgtg gccagagcca gaagcggtga
     7201 aaggggcagc ttccgattgt ctgctgctgg agcggaagcg ctcggcagct ctgtctggga
     7261 tgtcgacatg gctgtatcct caaaccctca cattggtgtg aatgtcaagc tcctgcgaag
     7321 aggtgggtca catgcggatc ggtgaactgt ccgagcggac cggaacccct cgtcggctgc
     7381 tgcgctacta cgaggagcag ggcctgctcg tcgccggtcg cgcgccgaac ggctaccggg
     7441 actaccccga aggctgtgtg aaccgggtac tgcagatcag ggggctgctc gactccggcc
     7501 tgccgacgcg gatcatcaag cagatcctgc cgtgcatcaa cgacccccgg gccatccacg
     7561 tctccgacgc gacgccggag acgatcgccg ccctggagac cgagcggcag cgcatgaccg
     7621 accggatcga gtgcctgctg cgcagccggg aggccatctc cggttacctc gacgccgtcc
     7681 gtgccgagtc gccggtggcc gcctgaccgt actggacggg gttggccagc acgacgccgt
     7741 ggctggccac gtcgatgacc atccggtcgc cgtcctcgat ccggaagccg tcgtggtacg
     7801 tggccttgtc ggcgccgagc agcaggtagt tgaccagccc cggccggcgc agatgcgggt
     7861 acgacaggac gtaccgcgtc atgtcctcga cgcggtggta gagggagtcc gcgccgcagg
     7921 agaagtcgcc ctcccaggcc ggggcgccgt cccgctcgat ggtgacccgg ccggtcaccg
     7981 tccgcggcgg ttcaccgagg aacagccagg gcgtcagcga ggtctcgcac agcttggcgt
     8041 acggcgtcca ggcccacggg ttcttcaggt gcagcccgat gtcgttgaag tcgttgccga
     8101 aggtgtagcc cgcgtagtgc ggcacaccgt cgtcgtcgtt gacgtggacc agggcgatct
     8161 ccggttcctc gatgagccag acggggtcgg ccggggtgac caggggctcg tcgggcatgc
     8221 gcagccagga gccgaatccc ttgaggtagt agttcggcgg ggtgaactcc tggtcggggg
     8281 ccgggtcgtg gtcgaacttg gagcggtggg tgcccatgaa gccgttgacc agggagttgt
     8341 tggtgctcgt gggcaacagc ggggggagga agcgcagttc ggggtcgccg gtggtcacct
     8401 cgaccgtctc ggcgccctcg gtcacggccg cgaggagcgc ttccggtccg gcgcccgcga
     8461 tgacggcggc gcgcacctgg tcctcggaca cccggtacag gacgtggggc tcaccgggga
     8521 ccgggatgcc ggtaccggcg taccgctgcc ccttgtactc gcattcgaag aggatggaca
     8581 tggcggtgtg ggttctcctt ggtggacggg gtgggcgggg cgggcggggc gggcggggtg
     8641 gtcgcgtcgt cagggggtgg gccggtcagg ggcggtgagg tcggtcagga cgtcggtgac
     8701 gcggtccagc gcggccctga tccagggcag ccgggtgggc tcgggggcgt ccagggccgc
     8761 caggcgctcg gcgtccgtct cgccgtagag gcggctggtg gcgacccgga gccgcaggca
     8821 gtgcgccgac tcgccgaagg cggtgccggg cagcagcccc actccgtacc ggtcggcgag
     8881 gagggcggcc agggcgtcgc cgccgcgcac gtcgtggacc gcggcgaggc ggtcccgcag
     8941 cggatggaag tccgggtaga ggtagcaggt ggcccgcacc ggtgcgagcg cggcgccggc
     9001 ggcggtgaac cgctcggccg ccgcgcgcac caccttctcg tgcagccgcc gggcggcggc
     9061 catgtacgcg accacctcgg gcggctcggc gaaggcccag gccgcggcgg cctgtacggg
     9121 ggccgcggtg ctcgaccaga tctggctggc gatgccgacc agccgggtgt gcacctcgcg
     9181 cccgagcggg ccctcgggca gccgggccac cccgagccgc cagccgccga gcgccaggtt
     9241 cttggtgagt ccggtggtga ccacggtccg ttccggtgcg aaggccgccg gggagaccgc
     9301 gggacgggcg gggtcgaaga ccaggtcgcg gtagatctcg tcggagacga cgaccaggtc
     9361 cagttcgcgg gccgcccgtg ccaggcgctc gaccgtgccc ggggtggcga cggtgcccgt
     9421 ggggttgtcg ggcagggtga ccaccacgca ccgggggtcc cgcccggcgg cgcgggcgag
     9481 gaccaccgcc tcgcgcagcg ccgccggatc gggcaccccg ccctcgcccg gcagggtggc
     9541 gaccgggatc ggccgcgccc cggccagccg ggcctgcgcc gcgtagctga cccagccggg
     9601 caccggcacc accacatcgc cgccgacggc cagcagcagg gcgaacagca gcggcttgct
     9661 gcccggaccg cagaccacca gggcggggtc cgcggccagg ccccgccgcc cccagtagcc
     9721 ggcggcggcg gaccgcaggg ccgcgctccc ggccaccggc ccgtaggcgt tgcggtccgc
     9781 cgccgcgccg agccgttcgc gcagcccggt caggacgggc agaccgatct cgccgcccgc
     9841 cagggagagg acctcctccc cggcacggcg ccgtcgggcc agcgcctcgt cggcggcgag
     9901 ggtcgccgac atggtgacgg gcacggatgc ggacatggtg gactccaacg ggtcgggcgg
     9961 ggcgggttga tgacgggcat tcagcacagg gggcgggcgg tcacaccccg gcgaagcgct
    10021 cccgcagggc gaccttgcgg accttcccgg tgagggtctt gggcagggcc gtgacggtct
    10081 ccaggcgctc cgggtagaag cgggggtcct gctccgcctc ccgcagatag gagcggatct
    10141 cctccagcgt cacggtggtg ccgcgacgcg ggacgacgac cgcgaggatc gggtcgtcga
    10201 ccgtgccgtt ggggccgacc agcgcggcct cggccacctt cgggtgccgg gagatgatcg
    10261 cctccagctc ggccatcggt acgacggtcc cgtcccgcag gatggtgtcc ttggcgcgcc
    10321 ccaggatgcg gatgccgccc cggccgtcct cgcgcgccac gtcaccggtg tcgaaccagc
    10381 cgtcctcgct gagttcggcg tcgaagacgt cctgctgctt gtagtagccg agcgcccggg
    10441 acgcgccgcg cacctggagg cggcccaccg tggcccgctg ggtgaggtcg tggcacaggc
    10501 tgatgcggat ctccatcgag tcgatgggcc ggccgtggct gtgcgccgcc cagtcctggt
    10561 tgtagtcgag ccggctgatg gtgacggggc cgaactccga catgccccac accgagtacg
    10621 tgcgcgcccc gaaggtctgg cgcagctcgt ccaccagcgg ctggagcacc ggcgccgcac
    10681 cggtgaccgt gtgccgcagg ctggagacgt cgtgcggatc gatccgctgg gcgcgggcca
    10741 ccccggagag ggtgggcggc gggccgtaca gcagggtgcc gccgtaccgc tcgaccaggt
    10801 ccagcagacc ggcgtggtcg ggtccgtcct ggaaggcgat cgtgccgccg agcatcaccc
    10861 cggcgaggat gccctgcccg aagccggagt agtgcaccag cggggtggtg acgacgacca
    10921 ccaggtcgtc gcggagcagg aaggtgtcca catagccgcg cacgcccgag tggaccgtgt
    10981 tctggctgtg caccacgccc ttggagaagc ccgtcgtacc ggacgtgaac agcaccacga
    11041 acggttcgtc ggggcgcagc tggcgaccct ccaggtcggc cgagcgctgc ttctcccagt
    11101 gggtggcgac gaagtggtcg tggaagtcga gggcgccctc gggggcgtgc ccgtcgacca
    11161 ccagcacgtg gtccagcggc agttcaccct tgagcgcggt gacggtctcg gcgagcggat
    11221 agccctccca ctggggcacg gtgacacaca ccttcgcctc ggtgagcgcc agccggtggc
    11281 gtaactcgtc ctcctggcag accggggcga tcgggcagat gaccgcgccg accgccatgc
    11341 aggcgaacat caggggcacc atctcccacc ggttgggcag ctgcacggcg accacgtcac
    11401 cgcgccgcac gtccagttcg agcagggccc cggcgaaccg gtcggtcagc cgcgccagtt
    11461 cggcgtagtc gagggtgtcg gtgcgcgcct cggcgaggcg gcgcccggcg atgaccggct
    11521 tgcgcggccg ctcccgtgcc tggcggcgca ggtcgtcgag gaaggtctcg tcccgccacc
    11581 agccgcgccg ccggtactcc gccatgcggt ccgcggccga cgcggtggcc aggatggcgg
    11641 tggtcgtgga ggtcatcccc gctcctcccg ccgggtcttg agcagttcgg gcagcgggtc
    11701 gccggcggtc gcggcggcga tctccagcag gtcccgggtg ttgcggcgga cccggtcgcc
    11761 gatccagtcg aagacccatg ccttgcgggc gtccgccgga aggccgaagg ggacgacccg
    11821 ggtgacggcc agggcggccg agccggcccc gccgatgttg gcgatcacgc ccgggaccag
    11881 ggtggcgccc gaggcccggg tcttctcccg cgcctcggcg ctggaggcga ggttcgcgcc
    11941 ctccaccacc agggcggccc gcagccggtg cgcgttgccg tcgttcaggg cgtgcttctg
    12001 cgcggcgagg accagcaggt cggcgtcgac gtcgagccag gcgtccggct cggcggagac
    12061 ggtgacgccc tgcggcagcc gggagcggtc gatcagcccg aactcgtcgg tgaccgacag
    12121 cagttcggcc accggaagcc ggtccgcgct gatggtgccc tcgacgtcgg ccacgccgac
    12181 gatcacatgg ccgcggtcct ccaggaaccg ggcgaccgcc cggcccaccg cgccgaagcc
    12241 ctgcacgacg acccgggcgg gcccggtacg gccgctcgcc tccagggcgg tgaccgccgc
    12301 cacgccgacc ccgtggccgg tgcagtcgat caggggctcg tagtacgtgc gccagtcgat
    12361 cggcatgtcc ggcgcgccca gccggtagcg ggggtcgtaa ccggcctgct cgaagaagac
    12421 ggcgcggtcg gcgggggtga cgcccatgtc gatgccgagg tggatcccgc cgtgcagcag
    12481 cggcttgacg gtacggccga aggtgcggaa cgtctcctca cggtccgtgc cgtcggcgac
    12541 gatgccgccc ttggcgccgc cgatgggcag cccggcgagg atgaacttgt gcgtcatgtc
    12601 gcgggcgaga ccggcgacct cttcctcggt gaccccggtg gtcatccgta cgccgcccat
    12661 ggccaggccg tcgtagaggg agtccacgac gacccagccc ctgagcgtgc cgccgctgcc
    12721 gttcagccgg accgtgaacg cgggctgtgg gttttccagt tcactcattg ccgagtcctt
    12781 gcctacgtgg aggtggtgag gggggagggg ccgtgcgcgt gtcactggta cagctcggcg
    12841 aagccccgca ggatctccag gccgtcgccg cggaattcca ggtgcgcctg cgagccgagg
    12901 atccggccgt cgtcggagcg caggaactcc acgggcgcgt gctcggagcg gccgatggag
    12961 cggaagccgg cgggggcttc ccggaggtag agggtgtgcc ggtggaagac ggtcacggtc
    13021 ggcttcacat gggtgaacag cggttcctcc ttgtccaccc gtacctcgta gccgccgacc
    13081 cgctgggggc cctcggcgag ccggccgccc gccgcgaccg cgaggatctg catgccgccg
    13141 cagatcccga agaccgggac gtcggcggtc atgacgaggt cgacgagcgg cctgtagtga
    13201 tcgcggtcgt aggcccgcac cttggtgccg ctcaggacga tcgcctggta gcggccgccg
    13261 agccggtccg gcacggacgc cgcgtcgacc gcgtcggtgt ccgagccgag ttcctcgaaa
    13321 cgcttgcgga gctgtttcag cgacagcgtt ccgttgttga cgacgagtac ccgggactgc
    13381 gccacgcgct tgctcctcat ggtcgggtga tgacggtgcc ggtgcgggcg gcgagcaggt
    13441 ccgtgaccgg cgcgctgccg atgacgacac gcgccacgcc cgcttccagg gcctcgccgg
    13501 cggcgcgcag cttcttgcgc atgcctccgg tcgcgccctt gtcgcggaac tcggcggcgg
    13561 cccgggccgt gatccggcgc accggttccc cgtcgatcag caggtgttcg acgtcggtga
    13621 ccagcaccag gtcggtggct tcggccgcgc cggcgatcgc ggccgcggcc cggtcggcgt
    13681 cggtgttgac ctcctgcccg gccgcgttgc gggcgagcgg ggtgatgagg caggcgtggc
    13741 ccggttgcag gttcttcagc gcggtggggt cgacgccggt gatcgggccg accaggttct
    13801 ccagcttgac cagctgcttg tcccgccacc accagcgctc gccctcgccc gcgctgacga
    13861 gcccgtcgct ggcgagcagc cgttccgcgg tgatcccgcg ctgttcgagc cggccgagga
    13921 ccgtctcgcc cagttcggcg ctgaccgcct tgatgtcctc gatgacctcg ggcgtggtcc
    13981 agcggctctg gttgccgtac cggtcgcgca ggatcgcgga gggctcccgg tagcgggcgc
    14041 tgagcctctt cagcggcttg gaccagccgt gcacgaggat cagcggccgt gcctcggcgt
    14101 gccgcgccag gtcgtcccac caggcaccgg cgagatcgtc gaggcagctg ccgccgagct
    14161 tgaccacggt cggggtggct tcggacgccg tttccggggc gctcatgcgg gcatcaccgg
    14221 ctgcatcgtc aggcccgtct cctcgggcag tgcgaaccgc ttgttcatgg cctggagcgc
    14281 ctggcccgcc gcgcccttga cgaggttgtc gagggcggcg aggacgacga tccggccgcc
    14341 ctcgtcgtcg tacaggacgc tcacgtcgca gaagttggag ccgaggaccg cctgcgggtc
    14401 gggcaccggg atcagcgtct cggtgttccg gcgcacccgc acgaaccgct gccccttgta
    14461 gaagcgcagg taggcgcgct ggagttcgcg gccgtccacc tggtcgtcgg tgaaggcgta
    14521 gacgctggcg agcagtccgc ggacatggga gacgccgtag gccgacatgg tcagcgagcc
    14581 gacggtgccc ggcttgccgc gctccagaaa gtcgctcacc tcggcggcgt gccggtgccc
    14641 ggtgggggcg tacggggcga tggcgccgtt gcgcagcggg tgcaggtccg gcacccgcag
    14701 ttgcaggccg ccgccgctgg agccgctctt gccgtccacg accacggtcc tcaggttcag
    14761 cccgaggccg agggtcagcg gggcgagccc gagggtgatc gcggtggcgt agcagccggg
    14821 tacggagatc agcggggcgc cggccagctg gtcgccgacg agttccggta cgccgtagac
    14881 gaagcggtcg gcgagtccgg ccgaccgggt ggccttgggg taccagcgtt cgtgccgccg
    14941 ggggtcgcgg atgcggaagg cgccgctcag gtcgatcacg caggggacgc ggtcggcgag
    15001 gagggccgcg agttcggccg agaccggggc gggcgtggcg aggaacacca cgtcgcagcg
    15061 ttcggcgagg gcgtccgcgg tgacgcgttc cacgaccagg cccaggtcga ggcggagccc
    15121 ggggtgcagt tgggcggggg tccggccggc gctggagtca ccgccgagga aggccagttc
    15181 gagttcggga tgctggctca ccagcctgat cagttcaccg ccggcgagcc ctgaggcgcc
    15241 gacgattccc acgcggatca tgcgaatatc tcctggaggt gacgggcgat ggccgccggg
    15301 atgtccgctc cggtgaccgc tgccacccct cgccaggcgg gggcgtggtt gacctcgttg
    15361 acgagatggc ccgtcggcgt cctgaagaga tcgactccgt agatgccgtc gccgagctgg
    15421 tccacgacac cgtcgaccag tttctgcacc tcggggtcgt gggtgagggc ccggctctgg
    15481 ttgccgagcg ccgcgttgct gcgccagtcg gcccccgcgc tctcgaactc ggcggcggcg
    15541 acgatctccc ggccgacgac caggcagcgc accgagccgc cgcccaggta cggctccacc
    15601 aggcaggcct gttcgaaggc gtggccgagg tcctcgacgt agtcgtagac ggactgcgcc
    15661 agatcggcgt cgcgcaccag ggtgacgcgt ttgcccatgc cgccgtagac gggtttgagc
    15721 accacgggca ggccgaggtc gtccagggcc cgggtgaagt ccttgcggga cagggcgagc
    15781 cggaactcgg gcaccggtac gcccgccgcg cgcagcaggg cgcgcagcac cagcttgttc
    15841 tcgcaggcgt ggatggcggt ggcggagttg aggacgggta cgccgctcga ctcggccagg
    15901 gtggcgagga ggccgccccg ggtgtagctg cggctgcgga ccagcagggc gtcgtagcct
    15961 tcgatggaag aggttccgga ctctcccagg cacagggact cgtcgttgat ccagtcgatc
    16021 cggagcccca ggtccggtgc gcggcggatg agttcgcgtt cctcccagcc gacccggtcc
    16081 gcgcgatggc gactctcagg gtcatctcac tggccccagt cgcgcagctg gacctcgacc
    16141 atctgcaggg acagccggcc gtcccgtatc tcctccacgc gcagcgtgag catgcactcg
    16201 gggcaggaga gggtctcgcc ccggaccatc gggggcacgg tcaggtcggt ctcgcactcg
    16261 gggcagtcgc cggtgagggt ggcggtggac atgggtcaac tcctggttcg tcgtacggga
    16321 tcgggtgggg catggcgccg ggggcggggc tggtgagggg gtcaggcggc ctggaagtcg
    16381 acggcggcct tgcggatcgt gtcccggtcg agcagggggg acccgtcgcg ttcctgccgc
    16441 tcggtgagcc agggggtgaa ggcgtcgagg tcgacggaga cgcccgagtc ggccagcgcc
    16501 cacgcgacga gcgccgtggt cagacgggta cggacgcgca gcccgcgggc gttgccgacg
    16561 agttcggcgg gcagcgtctc gtacgcctcc gggtgggtga gctggcccgg cagttcgtag
    16621 gcgaaggcgt gcggggtggt cgggcccgac tggaaggcgt ccccgaggcc ggcgccgcgc
    16681 agcgcgacgc gcgacagctc ggtgaggtgg ctcaggtcga agcgggtgtc gtcgtggatg
    16741 acgcgcagtg aggtgagcag ttcggcgagc ggggcgttgc cgccgcgttc cccgatgccg
    16801 ccgacggtgg ccgagatcca ctgcgcgccc gcgcggacgg cggcgaggga gttggcgacg
    16861 gccatgccga gcatgttgtg cgagtggatc tcgatctcgg agccgtcgat cgcggtgagg
    16921 ttcccgatga ccgcctccat ctgccagggc gacagatacg cgacggtctc ggccagccgg
    16981 aaccggtcgg cgcccgcctc gaagccggcg gtgacgtagg ggacgaggcg ctcctcgggc
    17041 gtgcgggcgc cgtcctcgcc gctgaaggtg acgtggaagc cgcgctcctt ggcctgggat
    17101 atcgccgaac gggccagggt gtgcaggaac ttggcgctgg acgagccgag cttgagctgc
    17161 gcgtgctgct cggaggtcgg gatggagtac atgatgtgcc gcacacccag gcgctcggcc
    17221 tcgtcgagtg cctgggcgac ctgccggcgg tcgcgcacca cgacgagcgt catgctgcgc
    17281 tccggtccga cggcctcatg ggtggcgagg accagatcgg cgtccttgga gcccggaccg
    17341 gacaccatgc cgacctcgac gagttcgatc ccggtcttca ccagcaggtc cgcgatgacc
    17401 gcggcgtcct tggggccgaa ctcgacgccg gccatgtgcg cggagtcccg cagggtcgcg
    17461 tcggacagcc ggggcggcct cggaaggctt cccccgtgct cttctcctgc cattgcgttt
    17521 tcctcctttt gcgagggccg cccaccatga tggtccgggc gatgtgaggg gacaacgact
    17581 ccgatgtcag agcattgtca aggactgtga gggaaagtca gcagcggtca gatctgtgaa
    17641 ttctccggga gctggtcgaa aaatctgcat tccacgtctg gaattgttcg aattgctggc
    17701 tacggtgacc gggcctgttt ccagcagatg ggagtggaga gttcgatgga aattccgcct
    17761 ttccccacgg gtgcgtgggc acgggaactc gccggccgcg tcgcggcacc caccaccgcc
    17821 gaccgcgacc gcgaacggcg ctgggacccg cggctcttcg ccgaactggc cggggccgga
    17881 cccgccggac cgggtctcac cggcgccctg gtcccgcgcg acctgggcgg cgccggtctg
    17941 tccgccgccc agaccctcga tctcctggcc gggctcggcg agggcgcccg ggaccccggt
    18001 ctcgccctcg cggtcggggt gcacgcggtg ctcgccaccg tcccgctgcg cgccttcggc
    18061 agcccctcgc agcgggagcg gtacctgccc cggatggcgt ccggcgagtg ggtcggcgcc
    18121 ctgtcgctgc accagacgca gggggcgtcc gtcaccccgg ccgtcagcgc acggcccgcc
    18181 ccggacgggt cgggccggtg gctgctcacc ggcgcactgg acctggtcgc gggcgcgccc
    18241 gtggcccatc acttcctggt cgtcgccgca cacggggacg gcggccggac ggcgttcgtc
    18301 gtggaccggt ccacccctcg gctgggcgtc ggcgaggcag gcccggacgc gatgccgacc
    18361 tgcccctggg gccggctggt cctggaggac tgcgcggtcc cggacaccgc ggtgctgggc
    18421 ggcgtcggcg gcgcggcgcg cgaggtggag ccgctgctgg cggcgctgga ctgggtcttc
    18481 tccagcgcgc cctggctcgg tctgctgcgc gcgctgaccc gggacgccgt cgacggcgcc
    18541 cgcgaacgcc ggctcttcgg ccggccgctc caccacgacc agtccgtccg gttcaccctc
    18601 gcggacctgg ccgcgcgctg cgaactcgcc gacgggatgc tccgccgggc cgccgagcag
    18661 ttcgactccg gcgcccggcc cgcgcaccgg gacgcggcgg ccgcccggct cttcgtggcc
    18721 gccgccgtgc gcaccgtcac cgacgcggcg gcccggctgt ccggcccgct cggcctcacc
    18781 ggcgaccacc tgaccggacg ggcccaccgc gacggactgt tcttcgccgg caccggaggc
    18841 ggcaccgagg tgctgcgccc ggtgatcgcg gcgtccctgc tcgaactcgg ctgaccaggc
    18901 tcgacacgag gagcgcacag gacatgacca gtacgacgag catgtacgac ccgaccggcg
    18961 cccccgcctt cgcgggcacc cccgcgaccg aggccgcctc cgcatccgag ggcaaccccg
    19021 cgaccgagac cgcccccgcg tccgagggct cccccacgtc cgagggctcc cccgccttcg
    19081 acggcaccgc cgccttcgag ggcatcgccg cccgggccgc ggagacggac gcgacgggcc
    19141 ggataccggc ccggaactgg aaggatctcg ccgacagcgg ctatctgcgg ctgttccacc
    19201 cgccggaggt cggcggcagc ggcgccgacg cccgcaccca ggcggacgcc atggaggcgc
    19261 tggcccgggc ctgccccggc acctactggg cggcgaccgt ctccgcgctg ctgtgcggca
    19321 agctgatcac cacctacggc gacctccgca gccacgagcc gctgctgcgg tccctgctgt
    19381 ccggggagaa gctggccgcc ttcgcggtgg tggagcgcac ggcgggcagc gacgccggca
    19441 ccttccgcac cacggtccgg cgcgccgggg cgcccggcgg cggcttcgtc atcgacggcg
    19501 agaagtccag gatcaccaac gcgcccgtcg ccgatgtcgc catcgtgctc gcccgccggg
    19561 agcggctgcc cggggacgac ggccccgact ggtgcctcgc cttcgtggac ctgcaccagg
    19621 cgggcgtcga gcggtacggg atcgcgcaca tggggctgcg cggcatgccg tggggcggga
    19681 tggtcttcac cgacgcccgg gtcgccgagg ccgatgtgct gcccgtgccg ttcgaggagc
    19741 tggccgaggg catggcgtgg ggctggctga agaactcgtt cgccgccatc gccgtcgccg
    19801 agtccgccct ggccgcctcc gtacggcacg cccgtgagcg ggtctcgttc ggccggccgc
    19861 tggcgcacat ggagggcgtg caggcccagc tcgccgagtc gcgcgcgcag atcgacgccg
    19921 cccggctgct ggcccgccgg gcgatgggcg agcgggcggc ggggcgctcg gcgcgggatc
    19981 tgatcgccat gctgaagatc tacgccaccg agatgggcgt cgaggtcgcc gcgcgggccg
    20041 tgcagatcca cggggcgacc ggtgtgaccc agggacacga ggtggaacgg ctgtaccgcg
    20101 acgcccagat gaacgtcatc ggcggcttca cctccaaccg gctgcgggag caggtcgccg
    20161 agggcctcgg cctggggccc gcggtctaca gcgccttcga ctgggtggca ccggccggtc
    20221 tcggccagga cccggcggga ctcgacggac cgccgcaccc ggaggagacg gcgcgtcaaa
    20281 agccgtaggg cgaatcgaat cacgccgccg cgggtccgta tccctttccg gggtccgggc
    20341 ccgcggaggc gattccgcgg tgttcgccgg ccgtgccgtc agccgtgccc catgcggtaa
    20401 ccgacaccac ggacggtgat gatccaggaa tgggcgccga gtttcgcccg caggctgcgt
    20461 acatgggtgt cgatggtgcg gctggaatcc gcccacgtgg tttcccagac ccgtgccatc
    20521 aattcctttc gggaaatgac gctctcgggg gtcgcggcca gggtgcgcag taattcgaac
    20581 tccttggcgg tgacattcag cggccgtccg tccagacgga cctcacgcgt tctgctgtcg
    20641 atgcacagcg ggccgaggga gagcggccgg gaccgctccg accgggggcg ggcccggcgc
    20701 agtacggcct cgatgcgcgc cagcatctcg cgctccccgc acgaggtgac cacgcagtcg
    20761 tccgccccgg cctggagggc gaggacccgg tccagttcgg tgtcgcgggc ggtgacggag
    20821 atgatgggct tgtccccggc ctcgcgtatc gaccggcaga cctccagacc gtcgatgtcg
    20881 ggaagatcga ggtcgagcag gaccaggtcc gcctgctgat gggcgctcag cgcctcggca
    20941 ccggtgtcga cgctccgcgc ctggaacccc tgccggcgca gcccgcgcac cctcgcctcg
    21001 gccccgccga catcgtcgcc gaccaccagc acgcgagtcg tgtccggttg cgcagcgtgc
    21061 cctgccatcg ctccccctcc tacgcatacg cgccagtctt cccttgatta aaagaacaca
    21121 cgtcctgttt tttgtacagc cgcacatgcg gagcaggacg ggtcaaaacg gggcggaacc
    21181 ggcgcatatt cctgtcacag tacgccgaga ggggtaacaa atccgaaatt tgcgctattt
    21241 cggatgctcg aaaacaggac gcctaacacg tacactcgct cgaaagcacc cacccggggg
    21301 gtccgggcgg ctggggctgt gaggtcacac ccttgtccgc aactgggtga tggctggcgt
    21361 tcgactcatc cgtcacagca cggtacgggg gtacacgaat gcaaatcgat cgaggtttga
    21421 acgcagcgcg gccccgggtg gggacccgga gccgccgatc tggaccggcc acgtgtcacc
    21481 cgtggccggc agcctcctgt tcgtcgctct cccgcaggag ccgctccgcc cggtagggcg
    21541 acaggtcgag cttggccagc accgccgggg tgacgatgct gggcagcagc agctggtaca
    21601 gaccggctat ctcctcggcc aggctcagct tctcctccag gacctccgtc acgagctgca
    21661 caccggtcca cgcgccgacg aacacccggg acacggccgc ggggtcggcg tgagccagca
    21721 gctcaccact ctccttggcc tcggtgagca gttcccgccc gagtgccacc cagtccggcc
    21781 accgcgtccc gaacagccgc cgcgccttgg ggtcgacggc cagccggatg gcggcgtgca
    21841 gtaccggctc cctgggcaac cggtgggcca gcagcagtcc gagatccacc cattcctgca
    21901 gtttgaacga ctgcgggctg agcccttcag tggtcacggc ctcgtccagc acggcgcgcg
    21961 ccatgtcctc cttggaggcg aagtggaagt acagggcccc tcgggtcagt ccggtccgct
    22021 cgactagcgc ggcgatggtc gcggcgtcgt acccgacctc attgaacaag ctcgccatgt
    22081 tctccaagat gagtttacga gtgcgaatcg cgcgatcctg cctcaccacc cggcaccttc
    22141 cagcagtccg tagatctgtc gtctgtcact cactgaaggg ccacctatga gtaaccgaat
    22201 gcccgttact ttatcagcgc aactcactcg agcgaactcc atgtcacgac tgaggacgct
    22261 gtgcgacagg cgggaggccc tgccgggtgc cgtcgatgtc gggcgtcccg cgcctcgcgg
    22321 caccggtccc agaccggaac tgggcgagta catccacctc agacacgccc cggcgatcct
    22381 cgtcggggcg tggcgccagg aggggccgga cagcttcacc gtgaccgccc gctggcccgg
    22441 gcacggcggc cccggcgcgt acgacccccg gctcctgacg cagaccatcc ggcagagcgg
    22501 actgctcgtc gcgcacgccg agtacggcgt gccgacgggg catcaggcgc tgctgagcaa
    22561 tctcgacatc acggtgcggc ccggcttcga ggcccccgag gtctcggacc tcgacgtcga
    22621 catcgcggtc acccggcccg agaggcgcag cctcggcatg gagttccgga tccggcggga
    22681 cggcgtcacc gtgtgcctgg cgaacacgaa gttcagctgg gtggcccccg cggtctaccg
    22741 acgggtgcgc ggcccgcact ccaccgtcga ctggggcggg tggcccctgc ccgagcccgt
    22801 cgaccgcggg ctgaccggac gggccgacga cagggacgtg ctcctggcgc ccggaacggc
    22861 cggccaccgg tggcggttgc gcgccgacgt ctccaacacc ctgctcttcg accaccccgt
    22921 ggaccacgtc cccggtctcg tcctcctgga ggcggcgtac caggcggccc acgccgcggc
    22981 gggcccgaag cccctcgaac tcacggacgt cgccatcggc tacgagcggt acgtggagtt
    23041 cgacgagccg tgctggatcg aggccgagtg gctgcccagc ctgatgcccg actggttcgc
    23101 catcgccgtc accgggcacc agggcggaga ggtcgccttc caggcgcagt tgagggggct
    23161 gcggccgtag ccgcgggccg gggcgggtgc gggtcgcgag gcccgccgcc cgtgcccgtg
    23221 ccgaggggac gccggtggtg cccgggtcag tgattggcga accctccgtc caccggcagg
    23281 accgtgcccg tcaggaaggg gcagcggtcg ctgagcagcc aggcggcggc ctccgcgatc
    23341 tcctccggct cggcggtacg gccctgcggg gtcagggagt tgaccatctg ctccaggccg
    23401 gggttgcgcg cgaaccagtc gacggtgatc tcgctgcgcg tggtgcccgg ggcgacggcg
    23461 ttcaccctga tgccccgcgc cgcgtactcg tcggcggccg ccctggtcag gccgacgacc
    23521 gcgtgcttgg aggcgatgta cggcgcggcg gcggggatgg ccaccaggcc ggccacgctg
    23581 ctgttgttga cgatcgcgcc gccgccgcgc ggcagcatcg cggctatctc gtggcgcagg
    23641 cagttccaca cgccccgcac gttcacgtcc atgatcgtgt cgtacacgtc gtcggtcatc
    23701 aggtgcagcg gagtgcggtc cccgccgatg cccgcgttgt tgaacgcccc gtccaggcgc
    23761 ccgtaccggg cgacggcgag gtccaccgcg cggcccgcgt cggcggcgac cgacacatcg
    23821 cccaccacgt acgacgcctc ggccttcctg tcctgtaatt cgctcacgag tgccgccagc
    23881 cggtcctctc ttcggccggt cagcaccacc gtcgcgccct ctccgctgaa caccctcgcc
    23941 gccgcggtac cgatgccgct gctcgcgccg gtgatgagga ccaccttgtc tgccagaagc
    24001 tcgctgtcca tggcgcgcag tctctcaagg gggtggggac cccaccggaa cgtccggatg
    24061 tcggccaagg ggcggtatcg gggcggcgat gatccggcgc ggaaacggcc aagtgtcgtt
    24121 aaatcgccac ccagagtgat gggtcgcgtg cctacggtga acactactgg cacgaacacc
    24181 gaggaagcgt catggccacc ccccaccggg ccttacggac gccgaccgcg cccgctcccc
    24241 gtccgccctg tcctcctttt cccgccctcg tccccccacc cgaagcggac gagccgcggc
    24301 cgaccgcggc cgccgtcctg gacgaactcc tggccggcaa cgcccgctcc accggtggcc
    24361 tcgcccggca gccgtacgtc cgtcccaccg ggcggcggcc gtgcgcggtg gtcatcggct
    24421 gtgtggacgc gcccgttccg ccggagctgg tcctcgacca gccgctcggg gagctgctgt
    24481 gcgtgcgtac cgccgggctg gtcctggacg aggccgtgct cgggtccgtg cagtacggcg
    24541 tgcaggagct cggcgcgccg ctcgtgctgg tcctcggaca cgagcggtgc gccgcggtgg
    24601 ccgccacgct ggagcggctg cgcaccgggg cgccggtgcc gggccatctg gagctgctgg
    24661 tggaggagat cgcccccgcc gcccgccgca cccggaaccg gccgggcgac tgggcggagc
    24721 acaccgtgcg ggcccagacc acctgggtgc gggacgcgat ccgggccgac cccgcgttcg
    24781 gggcggcgcg ggtggtggcc gcgcgggtgg acgacgggac ggggctggtg tcgctgctgc
    24841 cctgaggccg ctccgtcctg aggccgctcc gtcctgaggc cgctccgtcc tgaggccgct
    24901 ccgaggggtt tgcgccacct cgaatggggg gctttcccca gtgtggtggg gggccggtgt
    24961 tttctagggt gagggcatga gcgcacgtga cccgcaggac gtcggactca agggcgacgc
    25021 cgagctgcgg aaggacctcg acgcgaccgt ccgcgcccgc cgggacctgg gagaggagta
    25081 cgactccgcc ctggtcgaat ccttcctgga gaaggtcgag cagcggctcg acggcgcggt
    25141 ggaccggcgg gtgcggcggc aggtggccga gcagcagatg gcggccgcgc gcggcaccgc
    25201 cggccgccgc aacccggtgg actcctgggg cgagaggtac ggcttcgccc tgctcaccct
    25261 ggtcctcgcc atcccgctgt ccgcgatcgc gggggccggc gcgggactcg ccggaatggt
    25321 ggtcacctgg ctcgggatcg tgggggtcaa cgcggcccag gtgatacgcg tgcaccctca
    25381 gctgctgtcg gggcggtccc gccggtccgg ccgggacgtg taaccccgct caccgcacac
    25441 ggaacagagc gaaaaagatt tgcgcgggga ccgccgcacc cccgttgccg gggggcggga
    25501 cgacggcggt ccccgcgggg gacgcgagcc gggtcagggc cgagccgcgc gtccttggcg
    25561 tccatggagg tccgggagcc gctccggaag tccgtgacgc cgacaacccc taatctgccg
    25621 gacgcgtgtt aagagggtgc tgcgtgcacg tgacaccctc gtaccactta cgcggcgaat
    25681 cgaacggccc cggtcaccgc gagttcgccg aggtcaggga ccacacccat ggcaccggcc
    25741 cccacctgcg cgggccgatc cccggcgcga cggacatgtg gcgtggattc gcgggagggc
    25801 gcagggggcg gggcggcgca cccactaccg tggcagctcg tccgatctct gtttcgccga
    25861 ggagcagccc gacgcacagc gcccctttcc gcctcgtcgt cccgggcggc gggaccggtg
    25921 gacacaccta ccccgcgctg accgcggtgc gcacgcttcg tcgtgggcga gggaagggga
    25981 tcgacgcccg tcagatcggc aggtaccagc cggggccgtc ctcggtggcg agccacaccc
    26041 gctggccggc ggccgagacg gtgattccga agccctcctg atgaggttcg ccggcagcct
    26101 gccagcgccg cacggcctgt tcgacccggt cccacagccg gacgggcccg cgttgtacga
    26161 cggtccactc gccgtcgggg ccaagggccg tccgggcctg tgaaccggtg gacacgtccc
    26221 agaggatctg ttccggtccc gcccccatgc gttcggccga aggtgccgcg agctgtgcga
    26281 cccagccgcc ggtccagtcg tcgagcctcg cggggtcgat ccggctcggg cgctcgtccc
    26341 ccggcaacag gaccagcgtc ggacgaggcg gccggtcgtg cggccgggcg atcatgaagc
    26401 tggtacagcc gggcaggaac cggcccatgg cctccccggg gccggtcacc tccagcagcg
    26461 cgagggcgtt ggcgtagctc cacccggaca gcgtgaccag gatctttccg ccgggcttca
    26521 cctggtgcag ccacgacagc gggacgtacc ggaccgaaca cgtggcgatg agccggtcgt
    26581 accggccccc gtccgggtcg ccgcgcagcc cgtcgccgat gatcagccgg ggcgcgaagc
    26641 cggccgcctt gagcgcggtg gcagcggcgc tggccaccac cgggtcgtac tcgacgctgg
    26701 tgaggccggc gtcgccgaga cggtgtgctc cgagagcggt cgagtacccg gttccggtgc
    26761 cgatctccag tacccggtgc ccggtctcga caccgagttg ctgccacatg cgcaacacca
    26821 gcgagggcag ggtggacgac gacgaagggg agcctgtcac ggtcccctcg gtcgcgtcgt
    26881 cgggcctggt gcggccgtcg agttgggtga tcagcgtctc gtcggagtag accccctcca
    26941 gccatccggg ctcgccctct cgcacggggc ggtaccgggt cgggacggtg cccgcgaccg
    27001 gcctgaagta ggagcccgtg aacagctcac ggggaaccgc cccggcggcg ctgcgccatt
    27061 cgggttccat ggacggagcg tcctcgctga gcctgtccac cagggcggcg cgtagccgag
    27121 tcgctgtgct cacgtgtcgg ggcctttctc caactggtcc gcgatggcac gggcgatcgc
    27181 cgcggtggtc tccgccggct gccacgccca ctggccgttc gggttgcact caaggaagta
    27241 ccagtcaccg gtggtggaca cggcgaagtc gaacgcgccg tagaccagat ggagttcggc
    27301 gaagtagacg gcgaccgcac gggcgaccga ctccggtagg tcgaccggtg tacacgccat
    27361 caggtcctgc cgatggcgcc agtcgaggtc ggggctgtcg atccggactc cgaacagtcg
    27421 gccgcctacg acggtcaccc gcgcgtcgaa cgccttgtcc accctggcct ggaacaggtg
    27481 cgggcagacg gacacggcgt cggtgatctc gactccgcgc acctcccgga cccacacgct
    27541 gtgtggctgg tcgtccacgc ggtagggcgt gttccacacc ggcttgtaga ccacgccgcc
    27601 gggctgacgg gcggcgaacg cccgtgcctc gtacgggtcg ttggtgatca acgtgctggg
    27661 caccaggaac ccgcagcgtc gcgcggtcga gagctgcgcg ggcttgaact cggcggctcg
    27721 gttgcgccag gggtgattga cgtagtgcgc gcccggcagg gaggcgagga tgccacccgc
    27781 gccccaccgc gcctgttcgg cggcgaaccg gcggtcccgc tccctcagcc cctgcggccc
    27841 ctcgtagggc gagggtctgc gcacccatac ggaccggacc cggccggtgt cgagttcccg
    27901 gctcgctgtg cgcaggacgc ccccctgacc gctcgtacgg tacgtggcgg tcagcgagga
    27961 gcccgtgtgc aggtcggtgc cggggtcgag acggaccacg ggaacccggc gatcgacgag
    28021 aagccgcaac accaggtccg ccgtcacatc acgggggttg gtcagcacca gtaccggcct
    28081 gctgtcactc atcagtcgga actctcgtcc tggtcgtacg actcggtgct gtccgcgtcg
    28141 gtcgcgccgt ccggtccgga gccgtcaccg
//
