LOCUS       NZ_CP047144            10411 bp    DNA     linear   CON 30-JAN-2024
DEFINITION  Streptomyces sp. HF10 chromosome, complete genome.
ACCESSION   NZ_CP047144
VERSION     NZ_CP047144.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. HF10
  ORGANISM  Streptomyces sp. HF10
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7814787)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Multiple polyene macrolides produced by antifungal Streptomyces from
            gut of Macrotermes barneyi facilitates the termite-fungus mutualism
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7814787)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-DEC-2019) State Key Laboratory of Microbial
            Technology, Shandong Unversity, 72 Binhai Road, Qingdao, Shandong
            266237, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-NOV-2018
            Assembly Method                   :: SPAdes v. NOV-2018
            Assembly Name                     :: SDU_Sthf_5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 05:29:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 6,988
            Genes (coding)                    :: 6,640
            CDSs (with protein)               :: 6,640
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 356
            CDSs (without protein)            :: 348
            Pseudo Genes (ambiguous residues) :: 0 of 356
            Pseudo Genes (frameshifted)       :: 235 of 356
            Pseudo Genes (incomplete)         :: 154 of 356
            Pseudo Genes (internal stop)      :: 18 of 356
            Pseudo Genes (multiple problems)  :: 53 of 356
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:39:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1994941
            Orig. end                         :: 2005352
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047144.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jinfeng Ni.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10411
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="9"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10411
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10411
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5411](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5411
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    190..204
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     misc_feature    complement(304..318)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.0"
                     /tool="antismash"
     gene            complement(681..1523)
                     /locus_tag="GR129_RS08625"
                     /old_locus_tag="GR129_08625"
     CDS             complement(681..1523)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121392.1"
                     /locus_tag="GR129_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08625"
                     /product="basic amino acid ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_159700272.1"
                     /transl_table=11
                     /translation="MKTPFGRRTRLLAATTATAGLVLVVAGCSSSDSGGGKSVAGGVHL
                     AKAGQLTTCTHLPYPPFQSVVDGKVQGFDVSLIDLVAKDLGVKQQIVDTPFENFKTGAF
                     LNSGQCDLAAAGMTITPERAKNVDFSDPYFEATQAVLVAKNSGITSLDGAKGKKLGAQA
                     QTTGEDFAKKKGLDPVSFASSDAVLNGLRTGQVQAVVIDYPVVQGWLKDKANADKFKVV
                     DNLKTGEQYGFTVKKGNKPLLKAIDKALKDAKADGTYKKIYEKWIGPYDSSVASPAGS"
     misc_feature    complement(1559..1573)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.31"
                     /tool="antismash"
     misc_feature    complement(1571..1587)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.94"
                     /tool="antismash"
     gene            1683..2783
                     /locus_tag="GR129_RS08630"
                     /old_locus_tag="GR129_08630"
     CDS             1683..2783
                     /NRPS_PKS="Domain: Aminotran_5 (74-300). E-value: 2.5e-26.
                     Score: 84.4. Matches aSDomain:
                     nrpspksdomains_GR129_RS08630_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037833.1"
                     /locus_tag="GR129_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08630"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_159700275.1"
                     /sec_met_domain="Aminotran_5 (E-value: 8.9e-20, bitscore:
                     69.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPLLDLPPLTARRFAAIEDRVARLLDTRQDVLITQGEALLPLE
                     GAIRAAAGPGTVALNVITGPYGRTFGDWLRDAGATVYDIAVPFHTAVRAEQIRAAFAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEAVREQGALFYLDAVASVGAEPVLPDAWGVDLCV
                     IGAQKAMGGPAGVSAISVSERAWARMAANPNAPRHSYLSLLDWKERWLDAGRTALPHAP
                     AQLEMLALDACLERIEADGPETVMARHRRAAAATRAGALALGGGLEPYVHDAGDAAPVA
                     TTLRVPSSLAASDLVAAALAADPALPLAAGGGALAKEMIRVNHYGPDATGSAVQASLAA
                     LGTALAARGATVDPAAARQAVERAWR"
     aSDomain        1905..2582
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GR129_RS08630_Aminotran_5.1"
                     /evalue="2.50E-26"
                     /label="GR129_RS08630_Aminotran_5.1"
                     /locus_tag="GR129_RS08630"
                     /protein_end="300"
                     /protein_start="74"
                     /score="84.4"
                     /tool="antismash"
                     /translation="RDAGATVYDIAVPFHTAVRAEQIRAAFAEHPEIDFVSLVHAEAAT
                     GNTNPVAEIGEAVREQGALFYLDAVASVGAEPVLPDAWGVDLCVIGAQKAMGGPAGVSA
                     ISVSERAWARMAANPNAPRHSYLSLLDWKERWLDAGRTALPHAPAQLEMLALDACLERI
                     EADGPETVMARHRRAAAATRAGALALGGGLEPYVHDAGDAAPVATTLRVPSSLAASDLV
                     AAAL"
     misc_feature    2948..2963
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.95"
                     /tool="antismash"
     misc_feature    3010..3025
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    3107..3119
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            3144..3661
                     /gene="ectA"
                     /locus_tag="GR129_RS08635"
                     /old_locus_tag="GR129_08635"
                     /pseudo=""
     CDS             3144..3661
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018545812.1"
                     /locus_tag="GR129_RS08635"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08635"
                     /product="diaminobutyrate acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTAASADLLIDRPETADGAALWRLAKDSKTLDLNSSYSYLLWCRD
                     FAGTSAVARDADGTPVGFITGYVRPDRRTPCSSGRSPWTPPSAAAASPPRCWTG"
     gene            3675..4946
                     /gene="ectB"
                     /locus_tag="GR129_RS08640"
                     /old_locus_tag="GR129_08640"
     CDS             3675..4946
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 1.2e-73.
                     Score: 240.0. Matches aSDomain:
                     nrpspksdomains_GR129_RS08640_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="GR129_RS08640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08640"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_145489159.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.3e-77, bitscore:
                     258.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETLESEVRSYCRGWPTVFDRAQGSRMYDEDGHAY
                     LDFFAGAGSLNYGHNNPVLKRALIDYLSRDGVTHGLDMSTTAKRRFLETFQNLVLRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGREAIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GVPLVHGTPMPFDNYFDGTVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP
                     EWLRALKELCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGLPMS
                     LCLFRPELDVWEPGEHNGTFRGNNPAFVTAAAALEAYWTDGSAMEKQTRTRGEQVEQAL
                     ISITEENLADVKEYRGRGLVWGLEFHAKDRAGRIARRAFELGLLIETSGPESEVVKLLP
                     ALTITPDELDEGLSILARAVRETA"
     aSDomain        3759..4772
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GR129_RS08640_Aminotran_3.1"
                     /evalue="1.20E-73"
                     /label="GR129_RS08640_Aminotran_3.1"
                     /locus_tag="GR129_RS08640"
                     /protein_end="366"
                     /protein_start="28"
                     /score="240.0"
                     /tool="antismash"
                     /translation="FDRAQGSRMYDEDGHAYLDFFAGAGSLNYGHNNPVLKRALIDYLS
                     RDGVTHGLDMSTTAKRRFLETFQNLVLRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     REAIVSFTNAFHGMSLGSLAVTGNAFKRAGAGVPLVHGTPMPFDNYFDGTVPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALKELCERQDMLLIVDDIQMGCGR
                     TGAFFSFEEAGITPDIVTVSKSISGYGLPMSLCLFRPELDVWEPGEHNGTFRGNNPAFV
                     TAAAALEAYWTDGSAMEKQTRTRGEQVEQALISITEENLADVKEYRGRGLVWGLEFH"
     gene            5001..5411
                     /locus_tag="GR129_RS08645"
                     /old_locus_tag="GR129_08645"
     CDS             5001..5411
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337952.1"
                     /locus_tag="GR129_RS08645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08645"
                     /product="ectoine synthase"
                     /protein_id="WP_145489157.1"
                     /sec_met_domain="ectoine_synt (E-value: 4.4e-54, bitscore:
                     180.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVKSKSGTWESKRIVLAKERVGFSLHETILY
                     AGTETQMWYANHIEAVVCTQGEAELTDRETGKTYTITPGTMYLLNGHERHTLRVKEDFH
                     CICVFNPPVTGREDHDENGVYPLLTEPEPEEV"
     gene            5418..6311
                     /gene="thpD"
                     /locus_tag="GR129_RS08650"
                     /old_locus_tag="GR129_08650"
     CDS             5418..6311
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448161.1"
                     /locus_tag="GR129_RS08650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08650"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_145489155.1"
                     /sec_met_domain="PhyH (E-value: 1.3e-36, bitscore: 125.5,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTATVKDLYPTRGATEVTVPRQDPVLWGTPDTPGPIAAAELQSY
                     ERDGFLAVDQLIGPGEVEVYRQELDRLVSDPAIRFDERSIVEPSSQEIRSVFEVHRISE
                     VFARLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNM
                     RTVSVSIALTENHDTNGGLMIMPGSHRTFLGCAGETPKDNYKKSLQMQDAGTPSDGALT
                     ELAGEYGIKLFTGKPGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFAAP
                     VRRPEFIGARDFTPVR"
     gene            complement(6385..7437)
                     /locus_tag="GR129_RS08655"
                     /old_locus_tag="GR129_08655"
     CDS             complement(6385..7437)
                     /NRPS_PKS="Domain: Aminotran_5 (17-344). E-value: 6.1e-25.
                     Score: 79.8. Matches aSDomain:
                     nrpspksdomains_GR129_RS08655_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522166.1"
                     /locus_tag="GR129_RS08655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08655"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_159700278.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.9e-18, bitscore:
                     65.2, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENFESLVRAEFRPENTYLNTATSGLLPARTLTALQEAVAIRAAG
                     RPLDPLFEDVERARAAFARLAGVPVSRVAAGPSVAAQTGLIAASLPAGAEVLTVEDDFT
                     SVVNPFHVRGDLKVRAVPLERLAEAVRPGTALVAVSAAQSADGRLADLPALRAAARAHG
                     ARTYVDFSQAAGWLPIDADGYDYTVATTFKWLLGPHGAAFLVVPEDLGGLTPLLAGWVA
                     AEDPWGGCYGPVAELARCARRFDVSPGLFTYSGVYASLTLIEELGVAAVHAHDLALAGR
                     FTEGIARLGHEPLPAPGSAIVSVPGLGARQAGLSRAGIQVADRAGSLRASFHLYNTAAD
                     VDRLLDALAG"
     aSDomain        complement(6406..7386)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GR129_RS08655_Aminotran_5.1"
                     /evalue="6.10E-25"
                     /label="GR129_RS08655_Aminotran_5.1"
                     /locus_tag="GR129_RS08655"
                     /protein_end="344"
                     /protein_start="17"
                     /score="79.8"
                     /tool="antismash"
                     /translation="YLNTATSGLLPARTLTALQEAVAIRAAGRPLDPLFEDVERARAAF
                     ARLAGVPVSRVAAGPSVAAQTGLIAASLPAGAEVLTVEDDFTSVVNPFHVRGDLKVRAV
                     PLERLAEAVRPGTALVAVSAAQSADGRLADLPALRAAARAHGARTYVDFSQAAGWLPID
                     ADGYDYTVATTFKWLLGPHGAAFLVVPEDLGGLTPLLAGWVAAEDPWGGCYGPVAELAR
                     CARRFDVSPGLFTYSGVYASLTLIEELGVAAVHAHDLALAGRFTEGIARLGHEPLPAPG
                     SAIVSVPGLGARQAGLSRAGIQVADRAGSLRASFHLYNTAADVDRL"
     gene            complement(7548..8267)
                     /locus_tag="GR129_RS08660"
                     /old_locus_tag="GR129_08660"
     CDS             complement(7548..8267)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436206.1"
                     /locus_tag="GR129_RS08660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08660"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_159700281.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALAAFPHREDVEVVHRSFELDP
                     GRAKGDVESVLTMLTRKYGMSEAQAEAGEDNLGAQAAAEGLDYRTRGRDHGNTFDMHRL
                     LHLAKERGRQDELIQALYRANFAEERSVFTGGDERLVELATGAGLDAAEVRAVLADSEA
                     YAEAVRADEREAAELGANGVPFFVLDRKYGVSGAQPAEVFTQALGQAWGERAPLTLVDQ
                     GGADACGPDGCAVPPRD"
     misc_feature    complement(8271..8284)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(8343..8855)
                     /locus_tag="GR129_RS08665"
                     /old_locus_tag="GR129_08665"
     CDS             complement(8343..8855)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018545806.1"
                     /locus_tag="GR129_RS08665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08665"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_159700284.1"
                     /transl_table=11
                     /translation="MISEPASTLEIRTALPAEAGAVAALHLRARSTYYPDGVPQAQLDW
                     TEAWRGSIERPDGRVLCAVREGRLAGVASFRTPDGAGPDTVKLFQFHVDPDRWRGGIGT
                     ALHAACAAEWRAAGRRTAVLDVHVDNLRAQAFYARQGWVPDPENPPAPGDHHLFLRYAV
                     PPGAPGE"
     gene            8938..9708
                     /locus_tag="GR129_RS08670"
                     /old_locus_tag="GR129_08670"
     CDS             8938..9708
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761328.1"
                     /locus_tag="GR129_RS08670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08670"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_159700287.1"
                     /transl_table=11
                     /translation="MTAGDAGGAQVKSAVRTVELLEYFAGRPGMHSLAAVQETVGYPKS
                     SLYMLPRTLVELGWVETDATGTRYGIGVRALLVGTSYIDGDEVVAAARPALDRLADHTT
                     ETVHLARLDGTGVVYLATRPSPHSPRPFTRVGRRLPAHSTSLGKAILATYTDDEVRALL
                     PPELPALTEHTLTDRERLIEELRRVRERGFAVDREENTVGLRCFGVALAYRSPARDAVS
                     CSVPVARLTPDRERTIKDALSEARDRLTLATRRL"
     gene            9784..10269
                     /locus_tag="GR129_RS08675"
                     /old_locus_tag="GR129_08675"
     CDS             9784..10269
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381155.1"
                     /locus_tag="GR129_RS08675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR129_08675"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_159700290.1"
                     /transl_table=11
                     /translation="MEIALRTVLDEDLPLFFRQMTDPVALRMAAFGPQDPTDRDAFEAR
                     LKRIRASCDVLRTVLADGRVAGSAAVYGEPGEREVTYWIDRAYWGRGVATAALRALLAE
                     VPERPLYARAAADNTASLRVLAKCGFRESVRARGFANGRGEEIEEVVLVLAADIPEA"
     misc_feature    complement(10370..10384)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.85"
                     /tool="antismash"
ORIGIN
        1 ccagggtgac gccgaggaac agcaccagcg aggagtcctt gaagagcagg acgagttcgt
       61 tggtcagcgg cggcaggatg atgcggaagg cctgcggcag gatgatcgag accatggccc
      121 gcgcgggtga gaagccgagc gaacgggccg cctccatctg ccccttgggc accgcctgga
      181 tcccggcgcg gatggtctcg gccatgtagg cggcggagac caggccgagc gccacggcga
      241 ccttgccgta ggtgccgccc gggtactgga cggtcgggaa ggccagcggc acgccgacgc
      301 cgacgaagat gaagatcagc agcgcgggca ggccgcggaa gatctcgatg tagatgccgg
      361 cgagccagcg gtaggggccc acggaggaca gccgcatcag ggcgatgacc atgccgaggg
      421 ccaggccgac gacgaacccg gacagcgtgt acagcacggt gttcttcagg gcgaccgtga
      481 tcagctcggg gaacagttgc ttggcgatgc cgggctgcgc gaactggttc tggagccgcc
      541 cccagtccgc ggtgagcgcg aaggcgagca ccgcggcggc gaggacggcg tactgggcgc
      601 cgcgcgagag cctgcgcttc tgcgtgcgcg tcagccccgt gcgcttcggc tggatgccgg
      661 tgtccgtgtc ggccatgggg tcaggaaccg gccggggagg cgacggagga gtcgtacggg
      721 ccgatccact tctcgtagat cttcttgtag gtgccgtcgg ccttggcgtc cttgagggcc
      781 ttgtcgatgg ccttcagcag cggcttgttg cccttcttga ctgtgaagcc gtactgctcg
      841 ccggtcttca ggttgtcgac caccttgaac ttgtccgcgt tggccttgtc cttcagccag
      901 ccctggacca ccgggtagtc gatgacgacg gcctggacct ggccggtgcg caggccgttg
      961 aggacggcgt cggaggaggc gaaggagacc gggtcgaggc ccttcttctt ggcgaagtcc
     1021 tcaccggtgg tctgcgcctg ggcgccgagc ttcttgccct tggcgccgtc gagcgaggtg
     1081 atcccgctgt tcttggcgac cagcaccgcc tgggtggcct cgaagtacgg gtcggagaag
     1141 tcgacgttct tcgcccgctc gggggtgatc gtcataccgg cggcggccag gtcgcactgg
     1201 ccggagttca ggaaggcgcc ggtcttgaag ttctcgaacg gcgtgtccac gatctgctgc
     1261 ttgacgccga ggtccttggc gaccaggtcg atcagggaga cgtcgaagcc ctgcaccttg
     1321 ccgtcgacca ccgactggaa cggcgggtag ggcaggtggg tgcaggtggt gagctgcccg
     1381 gccttggcga ggtggacacc gccggccacg ctcttgccgc cccccgagtc actggaggag
     1441 cagcccgcca cgacgagcac gaggcccgcg gtcgcggtgg tggcggccag caggcgggtc
     1501 cggcgtccga agggcgtttt catgggggga gtctcctgag gagggaacaa taggttccga
     1561 ttataaggaa atgtttgggt atctcaaacc aaacccatgg ccttggaggg cctggaccta
     1621 agatcggggg gagcagaccg ctgtgacccc tgcgaacctc ccgacgaaga gagagcaccg
     1681 ccgtgacgca ccccctcctc gacctgcccc cgctgaccgc gcggcgcttc gccgcgatcg
     1741 aggaccgggt ggcccggctg ctggacaccc ggcaggacgt actgatcacc cagggcgagg
     1801 cgctgctgcc gctggagggc gcgatccgcg ccgccgccgg tcccggcacg gtggcgctga
     1861 acgtgatcac cggcccctac gggcggacct tcggcgactg gctgcgggac gccggcgcga
     1921 ccgtgtacga catcgcggtc cccttccaca cggcggtgcg ggcggagcag atccgtgccg
     1981 cgttcgccga gcacccggag atcgacttcg tctcgctggt gcacgcggag gcggcgaccg
     2041 gcaacaccaa cccggtcgcg gagatcggcg aggcggtacg ggagcagggc gccctcttct
     2101 atctggacgc ggtcgcctcg gtgggcgccg agccggtgct gccggacgcg tggggcgtgg
     2161 acctgtgcgt gatcggcgcg cagaaggcga tgggcggccc ggcgggcgtc tcggcgatct
     2221 cggtgagcga gcgggcctgg gcccggatgg cggcgaaccc gaacgcgccg cgccactcct
     2281 acctctccct gctggactgg aaggagcgct ggctggacgc cggccgcacg gccctgccgc
     2341 acgccccggc ccagctggag atgctggcgc tggacgcctg cctggagcgg atcgaggcgg
     2401 acggcccgga gacggtgatg gcccgccacc ggcgcgcggc cgcggccacc cgggcgggcg
     2461 cgctggccct cggcggcggc ctggagccgt acgtccacga cgccggggac gccgccccgg
     2521 tcgccacgac cctgcgcgtc ccctcctcgc tcgcggcctc cgatctggtc gccgccgcgc
     2581 tggccgccga ccccgccctc ccgctggccg cgggcggcgg cgccctggcc aaggagatga
     2641 tccgggtcaa ccactacggc cccgacgcca ccgggtccgc cgtccaggca tccctggccg
     2701 ccctgggcac ggccctcgcc gcgcggggcg cgacggtgga cccggcggcc gcccggcagg
     2761 ccgtggagcg ggcctggcgg taaccgcgag gaattcccgg gcagcacgac ggcccgcgcc
     2821 ccgaggcgcg ggccgtcgcc atgcgcgcgg gtattcccgg ggaatgaatc gacgacgcta
     2881 aatctcgaat tcaattcggc ttcacaattc ccgctaattt cccggacggc agcttcccat
     2941 actcttctgc ccgctttttg cacggctaaa cgggccagtt ttccgggaga tttccgacgg
     3001 tttcaggggt gtgacacacc ccacaaagtt taggttttgc cccactttgc cataggtcaa
     3061 agcggtcatt tcgctccgct tgtcgagcgg cgccacatct gcggtgatgc atttttaaat
     3121 ttgcctcgct aaattcgtgc cgcatgaccg ccgcatccgc agacctgctc atagaccgac
     3181 cggaaacggc cgacggcgcc gcgctctggc gcctcgccaa ggactcgaaa acgctcgatc
     3241 tcaactcgtc ctacagctat ctgctgtggt gccgggactt cgccggcacc tcggcggtgg
     3301 cgcgtgatgc ggacggcaca cccgtcggat tcatcaccgg gtacgtgcgg cccgaccgcc
     3361 ggacaccctg ctcgtctggc aggtcgccgt ggactccgcc cagcgcggcc gcggcatcgc
     3421 cgccgcgctg ctggacgggc tgaccgcgcg gctcgccgcc gagcgcggcg tcacccgcct
     3481 ggagaccacc atcgcgcccg gcaacaccgc ctccgagcgg ctgttcacct cgttcgccga
     3541 gcggcacggc gcgcacctca cccgcgaggt gctgttcccc gccgagctgt tcccggacgg
     3601 cccgcacgac tccgaagtcc tctaccgcat cggcccgtcg accgattccc acgccctctg
     3661 aggagcgaat caccgtgacc atcacccagc ccgacctcag tgtcttcgag accctcgagt
     3721 ccgaggtgcg cagctactgc cgcggctggc ccaccgtgtt cgaccgcgcg cagggcagcc
     3781 ggatgtacga cgaggacggc catgcgtacc tcgacttctt cgccggtgcc ggatcactca
     3841 actacggcca caacaacccg gtgctcaaac gggcgctgat cgactatctg tcccgggacg
     3901 gggtcaccca cggcctggac atgtcgacca cggccaagcg ccgcttcctg gagaccttcc
     3961 agaacctggt gctgcgcccg cgcgacctgc cgtacaaggt catgttcccg ggtccgaccg
     4021 gcaccaacgc cgtggagtcg gcgctgaagc tggcccgcaa ggtgaagggc cgcgaggcca
     4081 tcgtgtcctt caccaacgcc ttccacggca tgtccctggg ctcgctcgcg gtgaccggca
     4141 acgccttcaa gcgggccggc gccggcgtcc cgctggtgca cggcaccccg atgccgttcg
     4201 acaactactt cgacggcacc gtcccggact tcctgtggtt cgagcggctc ctggaggacc
     4261 agggctccgg tctgaacaag cccgccgcgg tgatcgtgga gaccgtgcag ggcgagggcg
     4321 gcatcaatgt ggcccgcccc gagtggctgc gcgccctcaa ggagctgtgc gagcggcagg
     4381 acatgctgct gatcgtcgac gacatccaga tgggctgcgg ccgtaccggc gccttcttct
     4441 ccttcgagga ggccgggatc acccccgaca tcgtcacggt gtcgaagtcc atcagcggct
     4501 acggcctgcc gatgtcgctg tgcctgttcc ggcccgagtt ggacgtctgg gagccgggcg
     4561 agcacaacgg caccttccgc ggcaacaacc ccgcgttcgt caccgccgcc gccgcgctgg
     4621 aggcgtactg gaccgacggc tcggccatgg agaagcagac ccgcacccgc ggcgagcagg
     4681 tcgagcaggc gctgatctcc atcaccgagg agaacctcgc cgacgtcaag gagtaccgcg
     4741 gccgcggtct ggtgtggggc ctggagttcc acgccaagga ccgtgccggg cggatcgcgc
     4801 ggcgggcctt cgaactgggc ctgctcatcg agacctcggg cccggagagc gaggtcgtca
     4861 agctgctgcc ggccctgacc atcacccccg acgagctgga cgagggcctg agcatcctcg
     4921 cccgcgccgt ccgggaaacc gcctgaacca cctgaaccac accgtccgac cgcaacgtcc
     4981 gaccaggagg aagcaccacc gtgatcgtcc gatcgttcaa ggacatcgaa ggcaccgacc
     5041 ggcacgtcaa gtcgaagtcg ggtacctggg agagcaagcg catcgtcctg gccaaggagc
     5101 gggtcggctt ctcgctgcac gagaccatcc tgtacgcggg gaccgagacc cagatgtggt
     5161 acgccaacca catcgaggcc gtcgtctgca cccaaggcga ggccgaactg accgaccgcg
     5221 agaccgggaa gacgtacacc atcacgcccg gcaccatgta cctcctgaac gggcacgagc
     5281 ggcacacgct gcgtgtcaag gaggacttcc actgcatctg cgtgttcaac ccgcccgtga
     5341 ccggacggga ggaccacgac gagaacggcg tctacccgct gctcacggag cccgagcccg
     5401 aggaggtgtg agcgaccatg accaccgcca ccgtgaagga cctgtacccg acccgcggcg
     5461 ccaccgaggt gaccgtcccc cgccaggacc cggtcctgtg gggcactccg gacacccccg
     5521 ggccgatcgc ggcggccgag ctccagtcgt acgagcgtga cggcttcctc gccgtcgacc
     5581 agctgatcgg acccggcgag gtcgaggtct accggcagga gctggaccgg ctggtcagcg
     5641 acccggcgat ccgcttcgac gagcgctcca tcgtggagcc gtcgtcgcag gagatccgct
     5701 cggtcttcga ggtgcaccgg atcagcgagg tgttcgcccg gctggtgcgg gacgagcgcg
     5761 tggtcggccg ggcccgccag atcctcggct cggacgtgta cgtccaccag tcgcggatca
     5821 acgtcaagcc gggcttcggc gcgagcggct tctactggca ctcggacttc gagacctggc
     5881 acgccgagga cggcctgccg aacatgcgca cggtgtccgt ctcgatcgcg ctgaccgaga
     5941 accacgacac caacggcggc ctgatgatca tgccgggctc gcaccggacg ttcctcggct
     6001 gcgcgggcga gacgcccaag gacaactaca agaagtcgct ccagatgcag gacgcgggca
     6061 ccccctccga cggggcgctg acggagctgg cgggcgagta cggcatcaag ctgttcaccg
     6121 gcaagccggg ctcggccacc tggttcgact gcaactgcat gcacggctcc ggggacaaca
     6181 tcaccccgtt cccgcgcagc aacgtcttca tcgtgttcaa cagcgtggag aacacggcgg
     6241 tggagccgtt cgccgcgccg gtgcgccgac cggagttcat cggcgcgcgc gacttcaccc
     6301 cggtgaggta ggcgccttct gacaccgggc cggggccttt acgtgtggga cgggaggccc
     6361 cggcccggtc atgtcccggc ggggtcagcc ggccagcgcg tcgagcagcc ggtccacgtc
     6421 cgccgccgtg ttgtagaggt ggaaggacgc gcgcagactg cccgcccggt cggcgacctg
     6481 gatgccggcc cggctcaacc cggcctgccg cgcgccgagt ccgggcacgg agacgatcgc
     6541 cgagccgggc gcgggcagcg gttcgtgccc cagccgggcg atcccctcgg tgaagcggcc
     6601 ggcgagcgcc aggtcgtgcg cgtgcacggc ggccacgccc agctcctcga tcagcgtgag
     6661 cgaggcgtac accccgctgt aggtgaacag gccggggctg acgtcgaacc ggcgggcaca
     6721 gcgggcgagt tcggcgaccg ggccgtagca gccgccccag ggatcctcgg ccgcgaccca
     6781 gcccgcgagc agcggggtca gcccgccgag gtcctcgggg acgacgagga aggcggcgcc
     6841 gtgcgggccg agcagccact tgaaggtggt ggcgacggtg tagtcgtagc cgtccgcgtc
     6901 gatcggcagc cagccggcgg cctgggagaa gtcgacgtag gtgcgcgcgc cgtgggcgcg
     6961 ggccgccgcg cgcagggcgg gcaggtcggc gagacggccg tcggcggact gcgcggcgct
     7021 gaccgcgacc agcgcggtgc cggggcgcac ggcctcggcg agccgctcca gcggtacggc
     7081 gcgcaccttg aggtcgccgc gcacatggaa ggggttcacc acggaggtga agtcgtcctc
     7141 gaccgtgagg acttcggcgc ccgcgggcag ggaggccgcg atcagaccgg tctgcgcggc
     7201 gaccgaggga ccggccgcca cccggctcac cgggaccccg gccagccggg cgaaggcggc
     7261 gcgggcccgc tcgacgtcct cgaacagcgg gtccagcggg cggcccgcgg cccggatcgc
     7321 caccgcctcc tggagcgcgg tgagagtgcg ggccgggagc aggccgctgg tcgcggtgtt
     7381 cagataggtg ttctccgggc ggaactcggc gcggacgagg ctctcgaagt tctccatgag
     7441 cccactgtgc gggtcggtga ggtccccgtc catcgcgcgt ctctccgggg atccgccaag
     7501 cgtttctcgg acgaccgcgc cgagccgggg tctcgcgccc cgcgcggtca gtcgcgcggc
     7561 ggcaccgcgc agccgtccgg gccgcaggcg tcggcaccgc cctggtcgac cagcgtcagc
     7621 ggggcgcgct cgccccaggc ctggccgagc gcctgggtga agacctcggc gggctgggcg
     7681 ccggagacgc cgtacttgcg gtcgagcacg aagaagggga cgccgttcgc gcccagctcg
     7741 gcggcctcgc gctcgtccgc gcgcaccgcc tcggcgtacg cctcggagtc ggcgagcacc
     7801 gcgcgcacct cggccgcgtc gagcccggcg ccggtggcca gctcgaccag ccgctcgtcg
     7861 cccccggtga agacggaccg ctcctcggcg aagttggccc ggtacagggc ctggatcagc
     7921 tcgtcctgcc ggccgcgctc cttggccagg tgcagcaggc ggtgcatgtc gaaggtgttg
     7981 ccgtggtcgc ggccccgggt gcggtagtcc aggccctcgg cggcggcctg ggcgcccagg
     8041 ttgtcctccc cggcctcggc ctgcgcctcg ctcatgccgt acttcctggt cagcatggtg
     8101 agcacggact cgacatcgcc cttggcgcgg ccggggtcca gctcgaagga gcggtgcacc
     8161 acctcgacgt cctcgcggtg cgggaaggcg gcgagcgcct tctcgaagcg ggccttgccc
     8221 acatagcacc aggggcaggc gatgtcgctc cagatctcga cgcgcatgtc ttcggctctt
     8281 tccaggtcgt acgggggcgg agacgatccc cgccgagtac gtgaacattc aaatgacccc
     8341 ggtcattccc ccggcgcccc cggcggcacc gcgtaccgca ggaacagatg gtggtccccc
     8401 ggcgcgggcg ggttctccgg gtccggcacc cagccctgcc gggcgtagaa ggcctgggcc
     8461 cgcaggttgt ccacatgcac gtcgagcacg gccgtgcgcc gtcccgccgc ccgccactcc
     8521 gccgcgcagg ccgcgtgcag ggccgtaccg atgccgcccc gccagcggtc cgggtcgaca
     8581 tggaactgga acagcttgac ggtgtccggg ccggctccgt ccggcgtccg gaaggaggcg
     8641 accccggcga gccggccctc ccggacggcg cacagcaccc gcccgtcggg ccgctcgatg
     8701 gacccccgcc acgcctcggt ccagtcgagc tgcgcctgcg ggacaccgtc cgggtagtac
     8761 gtcgagcgcg cgcgcagatg cagtgcggcg acggccccgg cctcggcggg cagcgcggtg
     8821 cggatctcca gggtgctcgc gggttcactg atcatgggac ggaggacgcc gtgtccgggc
     8881 cgccggttcc cggtgttctc tgcactggac gccgtcgaag cgaaggggcc gagggcgatg
     8941 acggcagggg acgcgggcgg cgcgcaggtc aagtccgcgg tacggacggt cgagttgctg
     9001 gagtacttcg ccggccgccc cggcatgcac tccctcgcgg ccgtgcagga gaccgtcggc
     9061 taccccaagt ccagcctgta catgctgccg cgcaccctcg tggagctggg ctgggtggag
     9121 acggacgcga cgggcacgcg gtacggcatc ggggtgcggg cgctgctggt gggcacctcg
     9181 tacatcgacg gcgacgaggt ggtggccgcc gcccgcccgg ccctggaccg gctcgccgac
     9241 cacaccaccg agaccgtcca cctggcccgg ctcgacggca ccggcgtggt ctacctcgcc
     9301 acccgcccgt ccccgcactc tcctcgcccc ttcacccggg tcgggcgccg cctcccggcc
     9361 cactccacct cgctcggcaa ggcgatcctc gccacgtaca ccgacgacga ggtacgggcg
     9421 ctgctgccgc cggagctgcc cgcgctcacc gagcacaccc tcaccgaccg ggagcggctg
     9481 atcgaggagc tgcgccgggt gcgggagcgg ggcttcgcgg tcgaccgcga ggagaacacg
     9541 gtggggctgc gctgcttcgg cgtggcgctg gcgtaccgca gcccggcccg ggacgcggtc
     9601 agctgctcgg tgccggtggc ccggctgacc cccgaccgtg agcggacgat caaggacgcg
     9661 ctgtccgagg cccgcgaccg gctgaccctg gcgacgcgca ggctctgagc gcggaccggg
     9721 gccgggggcg agccgcgcgc cgcgctccgg cacggcggtc gcaccgtcgt agtctcgggc
     9781 cccatggaga tcgcgctgcg gaccgtcctc gacgaggatc tgccgttgtt cttccggcag
     9841 atgaccgacc cggtggccct gcggatggcc gcgttcggcc cccaggaccc gaccgaccgg
     9901 gacgccttcg aggcccggct caagcggatc cgcgcctcct gcgacgtgct gcgcacggtg
     9961 ctggccgacg ggcgggtggc cggcagcgcg gcggtctacg gggagcccgg cgagcgcgag
    10021 gtgacgtact ggatcgaccg cgcctactgg ggccggggcg tggcgacggc cgcgctgcgc
    10081 gccctgctcg ccgaggtccc cgagcggccg ctgtacgcgc gggcggcggc cgacaacacc
    10141 gcctcgctgc gggtcctggc caagtgcggc ttccgcgagt ccgtccgggc ccggggcttc
    10201 gccaacggcc ggggcgagga gatcgaggag gtcgtgctcg tcctggccgc ggacatcccg
    10261 gaggcatgac ccggggcgca tgagtacggg atgaacggga catgagaatt cccggcgcga
    10321 gggaacgttc gtgcccttcc cggacgtctt ccgtacggga tgaacgggat gaacaagacg
    10381 atcaggcgag cgtccgtctt ctcgctgctg c
//
