LOCUS       NZ_CP047146            25177 bp    DNA     linear   CON 30-JAN-2024
DEFINITION  Streptomyces sp. GS7 chromosome, complete genome.
ACCESSION   NZ_CP047146
VERSION     NZ_CP047146.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GS7
  ORGANISM  Streptomyces sp. GS7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9067183)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Multiple polyene macrolides produced by antifungal Streptomyces from
            gut of Macrotermes barneyi facilitates the termite-fungus mutualism
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9067183)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-DEC-2019) State Key Laboratory of Microbial
            Technology, Shandong Unversity, 72 Binhai Road, Qingdao, Shandong
            266237, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-NOV-2019
            Assembly Method                   :: SPAdes v. Nov-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 05:53:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,019
            CDSs (total)                      :: 7,925
            Genes (coding)                    :: 7,616
            CDSs (with protein)               :: 7,616
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 107 of 309
            Pseudo Genes (incomplete)         :: 258 of 309
            Pseudo Genes (internal stop)      :: 29 of 309
            Pseudo Genes (multiple problems)  :: 79 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:40:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8802037
            Orig. end                         :: 8827214
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047146.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jinfeng Ni.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25177
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="37"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25177
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25177
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15177](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15177
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            260..1705
                     /locus_tag="GR130_RS38385"
                     /old_locus_tag="GR130_38385"
     CDS             260..1705
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010644471.1"
                     /locus_tag="GR130_RS38385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38385"
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_159509148.1"
                     /transl_table=11
                     /translation="MRHPLNPHDFGYSLGTSQRPKGVELWSRADKTCRVIGPMGSGKTL
                     RFFAPTIRNWAGPVLATSTKPDLVELTLDARRRDGRPVMVFDPQNIAPSLPKFRWTPIT
                     GASETEIAMMRAKAFVAGSRTPGSATQSSEGSTFYKGQASKILAAFFHAAALDGANLDW
                     VLKWARKLTDPAPLGILNAHPGAGPGWADMLRTATTGDSRTVGNTAATLDAALEPLMHQ
                     SVIRALQGDGEDPTDFHEFLDAEGTIYLLGKDSEVNSVAPLTTAIAEGLLDLAEAHALA
                     SPAGRLDPALLAALDEAPNIAPIPSLRQRVADGRGRGITVIYGLQGWASAIARFGEDTA
                     NELAAFTNHVVVFGGAKDPVFLKDMSDLCGQVERERTTKTTTGGDRGGHSTATHMALEP
                     VLRGDEIRALPEGHALVLADNLPPVVTRLDGMWTWASWAEIEGRVRDLRSANEAERSRQ
                     AAEQKRQAEAHAAAWAKRQGVAA"
     gene            1702..2175
                     /locus_tag="GR130_RS38390"
                     /old_locus_tag="GR130_38390"
     CDS             1702..2175
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447313.1"
                     /locus_tag="GR130_RS38390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38390"
                     /product="hypothetical protein"
                     /protein_id="WP_159509150.1"
                     /transl_table=11
                     /translation="MTTNPLARLTPFPEPPSLIAEYLAERAVVQSVVDGPAPWDIGALT
                     QELVDAMSVWLDAVCRWLNASYAWQPHQVIPPCWTEHDHLPYEVAAFAFARIDAYNDAG
                     SVIVWHEQYDRFVTRMNNALGKTADDCRAGKHDARPSRFALASWPTRVEEELV"
     gene            2175..2624
                     /locus_tag="GR130_RS38395"
                     /old_locus_tag="GR130_38395"
     CDS             2175..2624
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447314.1"
                     /locus_tag="GR130_RS38395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38395"
                     /product="hypothetical protein"
                     /protein_id="WP_159509152.1"
                     /transl_table=11
                     /translation="MHPEPHVTFASDPRRGLVARSGWEQEEARTVLRDLGWEWDEHVHA
                     MMPPDDADPSDAGVQAVLELHRHGHLTGYRHGPYGTLQFRLAEADRVFTQIIAGKPSAA
                     TNRPETPDDGPSRRATGGTPPSYADKYAGNVDNEAPGRLTTTPEL"
     gene            complement(2996..3199)
                     /locus_tag="GR130_RS38400"
                     /old_locus_tag="GR130_38400"
     CDS             complement(2996..3199)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179301.1"
                     /locus_tag="GR130_RS38400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38400"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_159509154.1"
                     /transl_table=11
                     /translation="MNVDLTGAKYFKSKYSGGNSQCVEVAHNLRGVVPVRDSKNPEGPA
                     LAFPPDAYSAFIAGVRDGYFRA"
     gene            complement(3196..4062)
                     /locus_tag="GR130_RS38405"
                     /old_locus_tag="GR130_38405"
     CDS             complement(3196..4062)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="GR130_RS38405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38405"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_159509156.1"
                     /transl_table=11
                     /translation="MTQKRATEPVKRRRVGGQLRLWREAAGLKPRDAAKLVGLDGPQLS
                     RMERGVYPVKAERVRTFAKLYEFDDEAAIEAVAEAAEVPLGTGWWAPYAPFVSQAYLDF
                     IELESEATTIRTHHPTVIPGLLQAPGYAREIISREGAAPSERPVKRLVAIRTGRQEVFT
                     RDVPVQVHALVHETALKAHFKSGTIVMREQLRQMIDYSELPGVTIQIIPLTTHPAYGAD
                     GAFTLLSFAHPWPSVTSIDGPGGGSHTEDPELFDVQSDEFESIASVSLTHGDSQQFLRE
                     QLEELQS"
     misc_feature    4129..4145
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.5"
                     /tool="antismash"
     gene            4344..4532
                     /locus_tag="GR130_RS38410"
                     /old_locus_tag="GR130_38410"
     CDS             4344..4532
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS38410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_38410"
                     /product="hypothetical protein"
                     /protein_id="WP_159509158.1"
                     /transl_table=11
                     /translation="MSNSSNPKRPETQTSRRRAMGIKARDARRTLAAERRDFRQRHGDP
                     AHWGSYECDLYLGLGGI"
     gene            4532..5035
                     /locus_tag="GR130_RS38415"
                     /old_locus_tag="GR130_38415"
     CDS             4532..5035
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS38415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_38415"
                     /product="hypothetical protein"
                     /protein_id="WP_159509160.1"
                     /transl_table=11
                     /translation="MANDLVKRSLLSQAPRNTEWMDRDNDVTLARRPRVSVDPALRLRH
                     LRKSYNDHVKELFAGPSHRRLVSYVIRPPGADASAVQSQLRELAETRGRHVIYDITDTT
                     ACDLRRREGYAKAISMIYAGRADGLVIPDMATITADYAHYEQQVRWLGERNAFLYLLIP
                     EGQQ"
     misc_feature    4652..4654
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5032..5154
                     /locus_tag="GR130_RS41490"
     CDS             5032..5154
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS41490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268977953.1"
                     /transl_table=11
                     /translation="MKPWHVLLDERGWRQIAAQVVYVGLLIVLMVLLAFGISSH"
     gene            5215..5820
                     /locus_tag="GR130_RS38420"
                     /old_locus_tag="GR130_38420"
     CDS             5215..5820
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="GR130_RS38420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38420"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_159509162.1"
                     /transl_table=11
                     /translation="MAATLVPETRSPDYWDHAYWKGARFLSVGREERQLLRAYTQLKSG
                     QFAVDAGCGRGSLAATMNGWGLNVLALDFSEVAIDAARNTFQEFENLRFDRFDFNADSE
                     HHMLQPGTVDLITCRLTFAFLDRPRFLGDCRRWLKADTGTLHITTAVHELAPPEHAHRG
                     LTLAEINALDDGHWQHVTRYPITLGGSVQGIVLRGPIR"
     gene            5961..6353
                     /locus_tag="GR130_RS38425"
                     /old_locus_tag="GR130_38425"
     CDS             5961..6353
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS38425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_38425"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_159509164.1"
                     /transl_table=11
                     /translation="MTLVERALAWDPENLTTPDLDTVLDMIEHFSQYGRVVANELRVLC
                     RSLPVGSAVAVRARATLGEADRRLNLPRSIANRQARHRAQNLARLLKALHRATGLVYEE
                     WPHTAGQVPRHTSTAEVDHSETDRPP"
     gene            6446..6616
                     /locus_tag="GR130_RS38430"
                     /old_locus_tag="GR130_38430"
     CDS             6446..6616
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS38430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_38430"
                     /product="hypothetical protein"
                     /protein_id="WP_159509166.1"
                     /transl_table=11
                     /translation="MNKARFTVQAAKTAGDRDNNGRSKAERQEQLGIRHTRQTHVCEDY
                     CNDPCPLNKPN"
     gene            7016..8239
                     /gene="fxlM"
                     /locus_tag="GR130_RS38435"
                     /old_locus_tag="GR130_38435"
     CDS             7016..8239
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955816.1"
                     /locus_tag="GR130_RS38435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38435"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_159509168.1"
                     /sec_met_domain="PCMT (E-value: 4e-36, bitscore: 123.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVPLDPDAATQLRNKVVDQLKKDGTIVSPGVEAAMRKVPRHLA
                     VPEASLDDAHSTYKAVVTQEDEHGNHTSSVSAPQIQAMQLEQAGIRSGDNVLEIGTSGP
                     NAAYLAELVGPSGQVTTVDIDPTPAARAERFLTETGYTNVNVVVADAEGGFPKNARYDA
                     IVVTVGAWDIPPTWIDQLKDDGRLVVPLRINGLARTYGFVRESDHLVATSAHPCGFVAM
                     QGAGSHTEKAMQLPGDEGVTLHFDEGPPADPSLLTGVLDTVRVETWTGVTVANREPIGT
                     LQMYLATHVPTYCSMSINPELASGAIGPTGLGFSMVAIDGPNFGYVVVRRNPEKQNAEF
                     GFHAFGPDGAGFAGRLADIVRTWGKDYRGASDPRITVYPAGTPDDRITGDRTIDKQHSR
                     ISVSWSAA"
     gene            8457..9668
                     /gene="fxlM"
                     /locus_tag="GR130_RS38440"
                     /old_locus_tag="GR130_38440"
     CDS             8457..9668
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953648.1"
                     /locus_tag="GR130_RS38440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38440"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_159509170.1"
                     /sec_met_domain="PCMT (E-value: 1e-42, bitscore: 145.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVREKSVGDEAASLRAEMVWELRNLGAITSESLASAVATVPRH
                     LFAADEPLKAAYAADQALVIKRDQDGTALSSLSSAHIQTVMLEQAEIEPGMRVLEVGSG
                     GYNAALIAELVGDAGSVTSVDIDAEIVERARTCLDTAGYHQVEVVQSDAIGGVPKHAPF
                     DRIVVTAGAWDIPSAWLDQLSERGRIVVPLRLRGLTRSIAFDRAGEGLVSDSYRLCGFV
                     PMQGAGAYTERLIRVADGIGLRVDDQRQDFDIETLAAAVRSPRLEVWSGAAFDLPDELE
                     LFLATSTPEMVMLHGSKGLVEQGVFALSVTRGVPTLVVGGSFAYRTKRPNEETGGFESG
                     VFAHGPDAESVAARYVELLRRWASDHRRRGAARIQYRPMPAGTAEPSQGIVAKQLGAVE
                     ISWT"
     misc_feature    complement(8470..8485)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.61"
                     /tool="antismash"
     gene            9738..9929
                     /locus_tag="GR130_RS38445"
                     /old_locus_tag="GR130_38445"
     CDS             9738..9929
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345935.1"
                     /locus_tag="GR130_RS38445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38445"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_159509172.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 6e-17, bitscore:
                     60.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVQFEDATATSRPQKAGHEGDLKGWDLDVSIVESGPSADRLIRM
                     TDDGCGQTCESACSATCP"
     CDS_motif       9738..9857
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSVQFEDATATSRPQKAGHEGDLKGWDLDVSIVESGPSAD"
                     /locus_tag="GR130_RS38445_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9858..9929
                     /prepeptide="core"
                     /locus_tag="GR130_RS38445_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-1.90"
                     /molecular_weight="2328.6"
                     /monoisotopic_mass="2327.0"
                     /core_sequence="RLIRMTDDGCGQTCESACSATCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSVQFEDATATSRPQKAGHEGDLKGWDLDVSIVESGPSAD"
                     /leader_location="[9737:9857](+)"
                     /alternative_weights="2346.6"
     gene            10001..13057
                     /locus_tag="GR130_RS38450"
                     /old_locus_tag="GR130_38450"
     CDS             10001..13057
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960873.1"
                     /locus_tag="GR130_RS38450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38450"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_159509174.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.6e-189,
                     bitscore: 629.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.3e-10,
                     bitscore: 39.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-26, bitscore:
                     92.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYEYVDAAMLRAVAWPPGHQVRSWPDPTAGAASWRTWLKQTLRIP
                     GFATALDQASPTLGHRVRDICGGKQLPEPAVWKAVLAVTRYLLRASSRATPFGLFAGVM
                     PARIAEVPTVHIGAGHRAVAMPDAAWLTAVIERLEVESALLPRLTVQAHALVVEKEGHL
                     ILRHRGDGSLGGPPAHVRVRATIPVRSAMDAARQPIRAVSLASKLAADFPHVPSDVIDK
                     LLVDLTAQRLLITNLRGPMTTTDPLGHLLDVLKAAEVEDITTVADIAAQLRQIADGLAR
                     HNTTSTRAREQRAQLTSAMQHLHPCSRPPLGVDLRLKGEVTIPHEVAAEAARAATALVR
                     LARRPFLSRAWTRWHGRFLERYGPRALVPVLEAVDDTGLGYPEGFLGGPPAEANGSLTE
                     RDLKLLALAQNAALRRQGEIVLDDSMIADLAAAGPEMRVQPTTELTVRVHAASARDLEP
                     GEFTLAVTGVSRTAGTVTGRFLHLLEPGDRERMTKAYAAAATATEGALPIQVSAPPLYV
                     GAENVARAPLAMPAVLTLGECHEHTDNRRVLLEDVAVTADTHRLYLISQTMRRPLEFVT
                     LNAVEPTHRTHPLVRFLTEANNSMSVPCTNFDWGAATSLPFLPALRYRRTILAPARWRL
                     TADELADREADGAQWNRALTAWRDQVAAPSTIYAGDGDQRIRLDLTEPAHRALLRAQVQ
                     RDGVAVLRAETAPDAGWVDGRAHELVIPLAFNGEPGPAPQWLDSGKTVGREHGHLPGCD
                     GRFLVKLYGHPDHYGSILTRFLPHLLTELGSTVRWWFLPYSDPNDHLRLRLIVPTDRAA
                     STPGAIGAWTQRLRQAGLISRVQWDTDFPETARFGGVQAIDAAEAYFAADSKAAAAQIT
                     YSSTKGGPDARALTAASMLDLTTSLIGNPAEAMSWLIDHAQTTSTPPARDLYDQAVTLG
                     NPNDRCDLARQPDGEQILARWAQRRETLAAYKAVLDTAGTASATALLPELLHLHHTRIA
                     GLDLKAEGQCLHLARAAALSWTARGRSGS"
     aSDomain        10460..10714
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GR130_RS38450_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.20E-12"
                     /identifier="RREFam001.1"
                     /label="GR130_RS38450"
                     /locus_tag="GR130_RS38450"
                     /protein_end="238"
                     /protein_start="153"
                     /score="39.4"
                     /tool="antismash"
                     /translation="ALVVEKEGHLILRHRGDGSLGGPPAHVRVRATIPVRSAMDAARQP
                     IRAVSLASKLAADFPHVPSDVIDKLLVDLTAQRLLITNLR"
     misc_feature    10835..10837
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13054..14283
                     /locus_tag="GR130_RS38455"
                     /old_locus_tag="GR130_38455"
     CDS             13054..14283
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953651.1"
                     /locus_tag="GR130_RS38455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38455"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_159509175.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-39, bitscore:
                     134.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPIPQALTAADILAAALADPCTAWVAAPGKRAWAQSLAGGAAGI
                     ALLHIERARTGRGDWNTAHAWLSQAASEDLTAASNASLYLGAPALAFVLRAAAGSTGRY
                     RSALEKLNDATIAVTQRRLAQAHARIDRGERPAMKEFDLIRGLAGLGAYHLAHQPHHKI
                     TTDVLTYLVRLTDPLPKQGDLPAWWTDVSPNGEPTAGFPGGHGNFGLAHGIGSALSVMS
                     LALLYGLDVPEMTDAVARICTWTDRWRQGDDTSPWWPGFISIEQATDGHIDLALRPRPS
                     WCYGVSGTARAQQLAGLALGEPARVQAAENAILAALRDPIQLDLLPEIGLCHGTAGLLH
                     TAWRMADQTTNPAIIAELPRVTDRLIAVLDRFDHEPELLDGTAGAALALHTAGTATAPV
                     SRWDAFLALA"
     misc_feature    13252..13254
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13705..13707
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14302..15177
                     /locus_tag="GR130_RS38460"
                     /old_locus_tag="GR130_38460"
     CDS             14302..15177
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138951.1"
                     /locus_tag="GR130_RS38460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38460"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_159509177.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-29, bitscore:
                     102.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNSPAWHQVNIAFPDWHRAEQTALAHLTPLLCTAEDEGAIGTWF
                     LIRKRPCWRVRYLPAPDTHVRIGRELEALTVAGHIATWTPAIYEPEVHAFGGAEAMMVA
                     HRLFHRDSRGLLTYLQHEDGTARGHRREMSLMLCSILMRSAGLDWYEQGDVWARVVAHR
                     PLPAADQSNTGRLHAAVHRLITVDTEDQLSQEGPLAHAAGWASAYTAAGHELAHLAASG
                     ALHRGLRAILAHHLLFAWNRIGLPYATQAALAATAKSVIFGPDPTTENSATAVNIGINT
                     TPSGPASAPR"
     gene            15213..16313
                     /locus_tag="GR130_RS38465"
                     /old_locus_tag="GR130_38465"
     CDS             15213..16313
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953653.1"
                     /locus_tag="GR130_RS38465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38465"
                     /product="hypothetical protein"
                     /protein_id="WP_159509179.1"
                     /transl_table=11
                     /translation="MDPHGPIAQRFPLVARARPACLPLPQRVQGLVDLAESAERQADQG
                     FASAVYNQSALIASDLNLPELAGKLCHQHADAYLHACPLPGKSAIRGLEPIVNLARLQI
                     RAGKADDGRRHLLNLYEAVSTGTAAQFGDIALPAHLTATPDDRHEVRAWLWTVLLADGT
                     RTLTSKGRWDEALTHIEEHRGVGKRMLDGRQVAVLAALVAGDPAGAVDLLEETTPGEPW
                     EQAVTACLTALCHRAASQPAAHRTHTLANMYAKLEPARGMAVFDARLGLTILDVIGSDQ
                     EPVTHRVVDTLYSRTTTLNDGHAARENLAHPLFTTLVTGKQQKNCQDIVDACALGAGKL
                     PDELHDQLAMALRTSDRTIRKGVTSK"
     gene            complement(16438..20859)
                     /gene="mobF"
                     /locus_tag="GR130_RS38470"
                     /old_locus_tag="GR130_38470"
     CDS             complement(16438..20859)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="mobF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447327.1"
                     /locus_tag="GR130_RS38470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38470"
                     /product="MobF family relaxase"
                     /protein_id="WP_236573861.1"
                     /transl_table=11
                     /translation="MIGSSDEQTEYRLTGGHGCGKAATVDAAPLVAAIEAKAEEAGTSV
                     ARLLGSTEAKKAFFRARAQLRNAKTARFTTFDAVEVASAAGLDAHELYGETIAPAPAAD
                     GQVDYHLNASERPLMWIGNGLAEFDIVPGSTLTPEQFQAARRLMRGEDPRTGQTLVEPK
                     LAIAPAAKLSAAPLVRAIRRSAAERGVKPDSLLDSQRKKAAFATMERQLTRFGEAHKVP
                     ASTLLKLAGAVGIDAVELYGEQALEKALLAEAGGRLDARALLHAVEEKARATGQQPTDL
                     FDSRSMKRRYQQTETEGGRRLRDLPMDVREAIAMAKAAGIAPEQVWDAEEIKAAMREGR
                     VEVGNRGTDVTLDLAKSKSAFLAYAPPKLAAEVEDIFTSAGCEAIEALQSWTAYGMRGR
                     HGDGQSADVIGTSGFSGWLMIHRAARPVGGAPYGDPHFHLHFTLANMAKGDDGQWSTVA
                     AGGRDIHRHTRATQSLMNARIRRELGDRYGISFRREERTGAWEIAAIPEATIRLFSKRD
                     SQIRQLLSKLGLDYDSATLRERTAASAASKAAKNGEAAGVEDDVLRAYWQAEGRAAGDD
                     PDAITTGAVGESVDQLNPSLEELCSIVFDPKTGLTSHSKEFTHAAAIAAVLDALPNGIG
                     TAAEAEKLTNSVLQQAGYAVKLNPRGAQHYAHADRYTTADIVAAEALIVTETTRRLNEQ
                     SAVVSGDTVVMTLSTVEAQQGFPFSAEQRAVLERLLTAGHGIDSVEGVAGAGKTTLMDA
                     ARQAWEAQGLVIAGASTAAVAAANLKAEAGITSRTLASWLMGIRKGGRGLAGVDVLVVD
                     EDAMCDDRDIAELLEHAAKTGTKVVGIGDPKQLHSPGVGGHFGAVHRIVGGLRLTENFR
                     QKDAVERRALQLWRDDRRVESLRTFAGTGRVHALANKDETLAAMLTIWADKRSAHSDDH
                     TAVQQLLMLAATNEIVEELNLGARALRKTTGDLIGPEHTYALAGGRELTLSVGDQVLLR
                     VNDYRAKKSRGANEDVLNGLRGIVRAVDDERRVLVEWRVKTVDGHEDHAEWVDADYIAQ
                     GGLSLGYAITGHKSQGLSVQETLVYGPGAQANALYTMMSRDKKESHLFLPLSVYETDAD
                     RARGGEALTDQEQLDRAVAGLIREVETGTEERMILTELPTAAVPAHVRQAVADLPTPRA
                     PGTGDPYEADGPEDAPQPEDRPTPSTTERPAPSASATETAPTTGCPYAHLSNVALHDAI
                     RKAATAARATRTAAEKAEAVADRAEQQAAAGTGPNVLALNRRHQDLTARAEAICEIRTL
                     TDVVAQHTHAKREVEERLHQLDYQLTATGRFGRPVLRGDDRVHAEAERGTLQQQRIEAA
                     RELEALHDRLQELCSLAGPAEEHEAVIAEAETLGRDKTVLLRRAQNKDNQAAKSVRGEA
                     TKARSTARGAAYREAGLREALSRRTGTQVAGQEAQEPSQKPQPASLYANRTVTDVQQHH
                     EAPEAPSAEPLL"
     misc_feature    complement(20922..20936)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     misc_feature    20967..20982
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.71"
                     /tool="antismash"
     gene            complement(21692..22345)
                     /locus_tag="GR130_RS38475"
                     /old_locus_tag="GR130_38475"
     CDS             complement(21692..22345)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447328.1"
                     /locus_tag="GR130_RS38475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38475"
                     /product="hypothetical protein"
                     /protein_id="WP_236573862.1"
                     /transl_table=11
                     /translation="MSRKTGRTLYSRADLRKVHGISEPTLQNLWTDRENNGHPPVADTI
                     DGVMHWDGDVWATWHHELQRQRAAASTTNPPKLDGDPEEMVGPAEAAKVCGFADSTTVS
                     HYVKNPPEGWPAPDDWDELPTRRRPKWKRWRLWQYLADRKGRGHAGGRPTGRRGLAYPY
                     QGDERLTLARQAIAANPGAKNAELIPQLQGQTEKTYSRPTWNLILNSAREHPEE"
     gene            complement(22390..22668)
                     /locus_tag="GR130_RS38480"
                     /old_locus_tag="GR130_38480"
     CDS             complement(22390..22668)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040353.3"
                     /locus_tag="GR130_RS38480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38480"
                     /product="DUF6211 family protein"
                     /protein_id="WP_071370502.1"
                     /transl_table=11
                     /translation="MLCDRHPDCPQPGDIAQLTRGNSIGADPGDSFVIVEDFPPTGRHL
                     VLNLPVDHPGRADWAAAVPLADIATLTRLEPAGSRTWAPAPDPDDIQ"
     gene            complement(22869..23477)
                     /locus_tag="GR130_RS38485"
                     /old_locus_tag="GR130_38485"
     CDS             complement(22869..23477)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040384.3"
                     /locus_tag="GR130_RS38485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38485"
                     /product="DUF6349 family protein"
                     /protein_id="WP_159509183.1"
                     /transl_table=11
                     /translation="MTATVAEPTGARARQTYYWRVRNARTRQSPGSAGQAWHIQPGHPG
                     GAYSDLGHELDPPEHHAPTLLSRSRPTGRRGDEQEFRGGCLACEWEGPVHSGNGFGDGD
                     NEAVEDAHDHCFPGWRALPPITTVEDRWAVPRSRSRWAQLTSQYPAGWIDQGAPVVAWR
                     RYRREAHAPPYTGRPRYELRVTRPPIDRGRRPTDQGALF"
     gene            complement(23474..23875)
                     /locus_tag="GR130_RS38490"
                     /old_locus_tag="GR130_38490"
     CDS             complement(23474..23875)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040345.3"
                     /locus_tag="GR130_RS38490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38490"
                     /product="DUF6181 family protein"
                     /protein_id="WP_159509184.1"
                     /transl_table=11
                     /translation="MDETTEARSTTRTPSRRGAATPSRDGVHRVGVPLQPRLTAAELIR
                     VLLAAPGETDLTALDPVRVRSLISAVLTQHGYDVLDRSPYYPELDRHQDARRAVRRAYG
                     SRFLDAPDEQAVLADPLREVLAAAGGGPS"
     gene            complement(23920..24348)
                     /locus_tag="GR130_RS38495"
                     /old_locus_tag="GR130_38495"
     CDS             complement(23920..24348)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010644434.1"
                     /locus_tag="GR130_RS38495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38495"
                     /product="DUF6197 family protein"
                     /protein_id="WP_159509186.1"
                     /transl_table=11
                     /translation="MPTRHTPESIVIADTPAAILQWAARHIEHVGIHQGPRLFAGPGRT
                     ATLPCWPRGALEVAAGHGRGAAGRTYDWDRIDRARDQAFGILAETLTGHPVDADDPAAA
                     KALHREAIDRWSAEPGRTAADAAHAFRTAAARAEHALF"
     gene            complement(24412..25056)
                     /locus_tag="GR130_RS38500"
                     /old_locus_tag="GR130_38500"
     CDS             complement(24412..25056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010644433.1"
                     /locus_tag="GR130_RS38500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_38500"
                     /product="hypothetical protein"
                     /protein_id="WP_159509188.1"
                     /transl_table=11
                     /translation="MTTQLLERPATVTDTEAGRLIVPATEGTTTVPTYRVGAPDIQCRY
                     PVIIGDDQVIGRAYRWHRDWFVVTTEGERNLRRPPKGTPGTEMAAAHLAEQYAAGRIGA
                     VPLDQVLAEAPTPLCGPVPLLHPRMPVNDRNIEGAQIAFAGLRAHHWRAVLTGFPGSDN
                     HWFLSCELCPWEGPKFWSHLRGRNGEPPSARRHKGGCIGEDKVRRLITAYH"
ORIGIN
        1 ccttgctggc gtgtgcgcgg ttgccctggt gacgctctgg gccctgacaa accggggccg
       61 acataacgcc gggttcgcat ccaaggggca gctcaaacgc cagatgtcgg ccaagacggt
      121 tatcaaggcc acggagatcc gcccctccct tacccgcggt gaagaccacc ccgaccgcac
      181 atcagcggtg agcctcgcga agaacagttc cgccggttcc tgacccgccg cctcgcctca
      241 cctcgttccg gagcacgtca tgcgccaccc cctcaatcct cacgacttcg gctattcgct
      301 gggtacctcg caacgcccga agggcgtaga gctgtggtcc cgcgccgaca agacatgccg
      361 ggtcatcggc cccatgggca gcggaaaaac gctgaggttc ttcgccccaa ccatccgcaa
      421 ctgggccgga ccggtcctgg ccacctcgac caagccggac ctggtggaac tgaccctcga
      481 tgcacggcgg cgcgatggcc gaccggtcat ggtcttcgac ccacagaaca tcgctccctc
      541 tctccccaag ttccgttgga cgccgatcac gggcgcgtcc gagaccgaga tcgcgatgat
      601 gcgggccaaa gcgttcgtcg ccggctccag gacccccggg tccgccacac agtccagcga
      661 aggcagcacc ttctacaagg gacaggcgtc aaagatcctc gccgcgttct tccacgccgc
      721 agctctcgac ggcgccaatc tggactgggt gctgaagtgg gcgcgaaagt tgactgaccc
      781 cgcaccgctc ggcatcctca acgcccaccc cggcgccggc cccggctggg cggacatgct
      841 ccgcacggcc acgaccggcg acagccgtac cgtcggcaac accgccgcga ccctcgatgc
      901 agcccttgaa cccctcatgc accagtcggt gatccgggct ctgcaaggag atggagagga
      961 ccctacggac ttccacgagt tccttgacgc tgaaggcacc atttatctgc tcggcaagga
     1021 cagcgaagtg aacagcgtcg ctccgctgac cacggcgata gctgaaggcc tactagacct
     1081 cgccgaggct cacgccctcg cgtccccagc agggcgtctc gacccggccc tcctggcggc
     1141 cctggacgag gcgccgaata tcgcgccgat cccctctctg cgccaacgtg tcgccgacgg
     1201 ccggggccga ggcatcacgg tgatctacgg ccttcaaggg tgggcgtccg ccatcgcccg
     1261 cttcggcgag gacacagcga acgagctggc ggcattcacc aaccacgtcg tggtgttcgg
     1321 tggagcgaag gaccccgtct tcctcaagga catgtccgac ctgtgcggac aggtcgagcg
     1381 ggaacgcacc acaaagacca ctaccggggg agaccgcggc ggccactcga ccgctactca
     1441 catggcgttg gaaccggtcc tgcgcgggga cgagatcagg gctcttcccg aaggtcacgc
     1501 cttggtgctc gcggacaacc tcccgccagt cgtcacccgt ctcgatggca tgtggacctg
     1561 ggcgtcctgg gccgagatcg aaggtcgcgt acgggacctt cgatctgcga atgaggcgga
     1621 gcgctcccgg caggccgccg agcagaagag gcaggccgag gctcatgccg ctgcctgggc
     1681 aaagcgtcag ggagtcgccg cgtgaccacg aacccccttg cccgcctgac gcccttcccg
     1741 gaaccgcctt cgctaatcgc cgagtacctc gcggagaggg cagtggtgca gtcggtggtg
     1801 gacggcccag cgccgtggga catcggtgcg ctgactcagg agttggtcga cgccatgtcg
     1861 gtatggctgg acgcggtgtg caggtggctg aacgcgtcct acgcctggca gccgcaccag
     1921 gtcattccac cgtgctggac ggaacatgat caccttccgt acgaggtcgc cgcgttcgcc
     1981 ttcgcccgga tcgacgccta caacgacgcc ggaagtgtga tcgtctggca cgagcagtac
     2041 gaccgcttcg tcacccggat gaacaacgcc ctcggcaaaa ccgccgacga ttgccgcgca
     2101 ggcaagcacg acgcccgccc gtcccgattc gccctcgcct cctggcccac gcgggtagaa
     2161 gaggagctgg tctgatgcat cccgagcccc acgtgacctt cgcctccgac ccccgccgcg
     2221 gactagtggc ccggagcggg tgggagcagg aggaagctcg aactgtcctg cgtgacctcg
     2281 gctgggagtg ggacgagcac gtccacgcga tgatgccgcc agacgacgcc gacccctcgg
     2341 acgccggagt gcaagctgtg ctggaactgc accgtcacgg gcacctgacg ggctaccgcc
     2401 acggccctta cggcacgctg caattccggc tcgccgaggc ggaccgtgtc ttcacccaga
     2461 tcatcgcggg gaagccctcg gccgccacaa acaggccgga gacacctgac gacggtccat
     2521 ctcggcgggc cacgggaggc actcctccgt cgtacgcgga caagtacgca gggaacgtcg
     2581 acaacgaggc cccggggcgg ctcaccacga cgcccgagct gtgaagcacc ttggccagag
     2641 gtgagctggc ccacgcttcc cgagcacacc gctctcgcgc gccgccgcat tgtcagacac
     2701 agtgggtacg ttcgggtgtg cacacaggcg aaggtgcccc gccccagctg accgggggcg
     2761 gggcaccttc atgtggtggg tcagtgtagg ttcccgcgct ccgaggccaa ttggccccta
     2821 acgacctgcg ggtttacccg cagcagctgt acggagtcgg gatgccttcc cggagttcgt
     2881 ggccacttcc tacgggccga aggccgttgg tggggcgttg acctgcgcag acctgccgtt
     2941 ggcctccgag tggccctgga tgctgggaag tggccccgtt tccgggaacc tacagtcagg
     3001 cgcggaagta cccgtcgcga acgccggcga tgaacgccga gtacgcgtcc ggcgggaagg
     3061 ccagagccgg cccttcaggg tttttgctgt cccgaacggg gacaacgccc ctcaggttgt
     3121 gcgcgacctc gacgcactgg gagttgcccc cggagtactt ggacttgaag tacttcgcgc
     3181 cggtcaggtc aacgttcatg attggagctc ctccagttgt tctcgtagaa actgctgcga
     3241 gtccccatga gtgagggaca cagaagcgat ggactcgaac tcgtccgact gaacgtcgaa
     3301 cagctcgggg tcttcggtat ggcttccgcc gcctggcccg tcgatgctgg tcactgacgg
     3361 ccagggatgc gcgaacgaca gcagtgtgaa cgcgccgtcg gcgccatacg ccggatgcgt
     3421 agtcaacggg atgatctgga tggtaacgcc cgggagttcg gagtagtcga tcatctggcg
     3481 cagctgctcg cgcatcacta tggtgccgga cttgaagtgc gctttgagcg cggtctcgtg
     3541 caccaaggcg tgtacctgca ccgggacgtc gcgcgtaaac acctcctgcc tgccggtacg
     3601 gattgcaaca agcctcttca ctggacgctc agatggtgcg gcgccctcgc gagagatgat
     3661 ctcccttgcg tagcccggag cttgaagcag acccggaatt acggtggggt gatgggttcg
     3721 gatggtcgtc gcttccgatt ccagctcgat gaagtccaga tacgcctggc tgacgaacgg
     3781 tgcgtacggc gcccaccatc ccgtgccgag cggcacttcc gcggcctcgg caacggcctc
     3841 gatcgccgct tcatcgtcga attcgtacaa cttggcgaag gtccgaaccc gctccgcctt
     3901 gaccgggtag acaccacgct ccatgcggga cagctgtgga ccgtccaggc caaccagctt
     3961 cgcggcatcg cgtggcttca agccagcggc ttcgcgccag aggcgcaact ggccgccaac
     4021 cctgcgtcgt ttaaccggct cggtcgcccg tttctgcgtc atggaggaag tctggcactc
     4081 ctcaggcgct ttggaaatac aacaagcggt tgcctccttt tgtaactcct gcttacacgt
     4141 tgcaagttgg cttgcaattg gagcatgctg gcgatgggca gtgacgcgag gtcaccttgt
     4201 gatcaccgac ggcagaggtg ctgcccaact tccgtcgtgc gactgggcgt tgatgggctc
     4261 cagctcgcgc ggcatcacgt ggccgtgcct tctatgagag gcgggggtac ggccacgtct
     4321 tcccccgctt gctggaggcg acgatgagca acagcagcaa tccgaaacgg cccgagacgc
     4381 agacgtcgcg acggcgggcc atgggcataa aggcccgtga cgctcggcgc acgctggccg
     4441 ccgaacgccg ggacttccgc cagcgccacg gcgaccccgc ccattggggc agctacgaat
     4501 gcgacctgta cttgggcttg ggtggcatct gatggccaac gatctcgtga agcgatccct
     4561 gctcagccag gcgccacgca acaccgagtg gatggacagg gacaacgacg tcacgctcgc
     4621 gcggcgaccg cgcgtctcgg tggatccggc cttacgactt cgccaccttc gcaagtcgta
     4681 taacgaccac gtcaaggaac tgttcgcggg cccgtcgcac cggcggctgg tcagctacgt
     4741 gatccggccg cccggggcgg acgcctccgc cgtgcagtcg cagctccgcg agctggcaga
     4801 gactcgcgga cgccacgtga tctacgacat cacggacacc accgcctgtg acctgcgcag
     4861 gcgagaaggc tacgccaagg ccatcagcat gatctacgcc ggccgggccg acggccttgt
     4921 tatcccggac atggcgacca tcaccgcgga ctacgcgcat tacgagcagc aggttcgctg
     4981 gctcggcgag cgcaatgcct tcctatacct cctcatcccc gagggccagc agtgaagccg
     5041 tggcacgtct tgctggacga acgcggctgg cgacagatcg ccgcccaggt cgtctacgtc
     5101 ggcctgctca tcgtcctaat ggtcctgctc gccttcggga tctcctcgca ctgatcgaaa
     5161 ggccccttga tgaaatcgct ggccaccccc cgtgcacaag ccggagccgg ccgcatggcc
     5221 gccacactgg tgcccgagac ccgtagcccg gactactggg accacgcgta ctggaaaggc
     5281 gccaggttcc tgtccgtcgg gcgggaggag cggcaactgc tacgcgccta cacccagctc
     5341 aagtcaggcc agttcgcggt agatgccgga tgcgggcgcg gttcgctggc cgccacgatg
     5401 aacggctggg gcctcaacgt cctcgcgctg gacttctccg aagtcgccat cgacgcggcc
     5461 aggaacacgt tccaagagtt tgagaacctg cggttcgacc ggttcgactt caatgccgac
     5521 tcggagcacc acatgctcca gcccggcacg gtggacctga tcacctgccg cctgacgttc
     5581 gccttcctcg accgcccccg cttcctcggc gactgccgtc ggtggctgaa ggccgacacc
     5641 ggcaccctgc acatcaccac ggccgtgcat gagctggcgc cgccggaaca cgcgcaccgc
     5701 ggcctgacgc tggccgagat caacgcgctc gacgacggcc attggcagca cgtgacgcgc
     5761 tacccgatca ccttgggcgg ctccgtgcag ggaatcgtcc tgcgcggccc catccgctga
     5821 ccccaccacg cgcaacgacg acaggcccag ctccacccca ctcctgggcc cactgccggc
     5881 cttttacttc ctgacatcac tgcggaacag gtgaccccgt ggctgcgctg actcctaccg
     5941 cccccgacaa agttcaggtc ttgacgctcg tcgaacgggc gctcgcctgg gacccggaga
     6001 acctgaccac tccagacctc gacactgtcc tggacatgat cgagcacttc agccagtacg
     6061 gacgcgtcgt cgcaaacgaa ctgcgcgtgc tgtgccgcag cctccctgtt gggtcggccg
     6121 tcgctgtgcg cgcacgggcc acactcggcg aggcagaccg gcgactcaac ctcccacgct
     6181 cgatcgccaa ccggcaggcc agacaccgcg cccagaacct ggcccgtctc ctcaaggccc
     6241 tgcaccgcgc caccggcctg gtctacgaag agtggccgca taccgcgggc caggttccac
     6301 gacacacctc tacggctgag gtggaccact cggagacgga ccggcccccg taggcgtctg
     6361 agtctctccg gcgccacgcc cggttcatgc tctgcgcccc tacacgtcgc agggcacacc
     6421 ccagtaagag acgagaaagg acatcgtgaa caaggcaagg ttcaccgtcc aggcggcgaa
     6481 gaccgctggt gacagggaca acaacggccg cagcaaggcc gaacggcaag aacagctcgg
     6541 tattcgccac acacggcaga cccacgtctg cgaggactac tgcaacgacc cgtgcccgct
     6601 gaacaaaccg aactagcccg ggcctgcgga taagtcccag gtagaagccg ggcagatccg
     6661 gcgggccgca cccccgaggc ggcctacctc acccggacct gctctacccg cccacctcgg
     6721 cgggcgggtg caccacctgg cagccggacc tgaatgaggc tcggtgccgg acgaacggtg
     6781 gggagggcgg tcccacgggg ccctccccat cccgactgct cgacggagag agggataaca
     6841 acaacgatca gctccacacc gcttttcagc cgatccccga cgcacatccc tcgtagcggc
     6901 gcgtattcgc cacggagacc agcttcctga ctagcgtgat ctgcctgacg agacgaccca
     6961 acgcgcctat cgctacgtgc agttgtacga gatccctgac gaaggaaacc gctctatgac
     7021 cgatgtgccc ttggaccccg acgcggccac ccagctccgc aataaggtcg tcgaccagct
     7081 caagaaggac ggcacgatcg tgtcgcctgg cgtcgaggct gccatgcgta aggtgccccg
     7141 tcacctggcc gtaccggagg cgtcgctcga tgacgcccac agtacgtaca aggccgtggt
     7201 cacccaggag gacgagcacg gcaatcacac cagttctgtg tccgctccgc agattcaggc
     7261 catgcagttg gagcaggccg gcatccggtc cggtgacaac gtgctggaga tcggcaccag
     7321 cggaccgaat gccgcctacc tcgcggagct ggtggggcct tccgggcagg ttacgaccgt
     7381 cgacatcgac cccacgcctg ccgcccgcgc cgagcggttc ctgaccgaga ccggttacac
     7441 gaacgtcaac gtcgtcgtcg ctgatgccga gggcggcttt cccaagaacg cccgctacga
     7501 cgcgatcgtg gtgacggtcg gcgcttggga catcccgccc acgtggatcg atcagctcaa
     7561 ggacgatggc cggctcgtcg taccgctccg catcaacggc ctggcccgca cctacgggtt
     7621 cgttcgagag agcgaccacc tggtcgccac cagtgcccac ccgtgcgggt tcgtggcgat
     7681 gcagggcgct ggctcccaca ccgagaaggc gatgcaactg cccggagacg agggtgtcac
     7741 cctgcacttc gacgaggggc cgcccgccga cccgtcgctg ctgaccggtg tcctggacac
     7801 cgttcgcgtc gagacatgga ccggggtgac cgtcgccaac cgggagccca tcggcaccct
     7861 tcagatgtac ctggcgacgc acgtgccgac gtattgcagc atgtccatca accccgaact
     7921 ggcctccggc gcgatcggcc ccaccggtct cgggttctcg atggtcgcga tcgatggccc
     7981 gaacttcggc tacgtcgtgg tgcgccgcaa cccggagaag cagaacgcgg agttcgggtt
     8041 ccatgccttc ggtcccgacg gggccggctt cgccgggcgg ctggccgaca tcgtccgcac
     8101 ttggggcaag gactaccgcg gcgcttccga cccgcgcatc actgtctacc cggcgggcac
     8161 acccgatgac cggatcaccg gagaccggac catcgacaag cagcacagcc ggatctcagt
     8221 ctcctggtcg gccgcgtagg acgcggcgcc tgaccaggtc tctcgcacca tcccatcgga
     8281 cagagagagt gatcacatga ccactgctct acgagcagca tcaccgcccc agttgggctg
     8341 ccgctcccgg gcagctccgc ctgtaccctt cgcgcacgcc tcgttctaac gaatggcaac
     8401 ggagccccta cagagagtgc cggggctgca cggaacacga acgattgggt gagtaaatga
     8461 ctacggtccg tgaaaagagc gtgggggacg aagcggcctc gctgcgggcg gaaatggtat
     8521 gggaactacg caatctaggc gcgatcacct ccgaatccct cgccagcgct gtagccaccg
     8581 tgccccggca tctgttcgcc gccgatgagc cgctgaaggc cgcgtacgcg gctgatcaag
     8641 ctctggtgat caagcgcgat caggacggta ctgccctcag ttctctgtcg tccgcccata
     8701 tccagacggt gatgctggag caggccgaaa tcgaacctgg catgcgagtc ctcgaagttg
     8761 gctcaggggg ctacaacgcc gcgctcatcg cagaacttgt cggcgacgcc ggatcggtta
     8821 cctcagtgga catcgatgcg gagatcgtcg agcgcgctcg cacgtgcctg gacacggctg
     8881 gataccacca ggtggaggtg gtgcagtcgg acgccatcgg cggcgtaccc aagcacgcac
     8941 cgttcgaccg catcgtcgtc acagccggag cgtgggacat cccctcggcg tggctcgacc
     9001 agctctccga gcgcggcagg atcgtcgtcc cgttgcgttt gcgggggctc acccgctcga
     9061 tcgcgtttga ccgcgccgga gagggcctgg tcagcgacag ttaccggctg tgcggctttg
     9121 tgccgatgca aggagccggc gcctacaccg agcggctcat ccgcgtcgcc gacggcatcg
     9181 ggctgcgagt cgatgaccag aggcaggact tcgacatcga gaccctggcc gcggccgtgc
     9241 gctcgcctcg gctggaggtg tggtccgggg cggccttcga cctgccggac gagctggagc
     9301 tgttcctggc gaccagcaca cctgagatgg tgatgctgca cggcagcaag ggcctcgtcg
     9361 agcagggcgt cttcgcgctg tcggtgacac gcggagtacc gacactggtc gtcggtggga
     9421 gcttcgcgta ccgcaccaaa cgaccgaatg aggagacggg cggcttcgag agtggagtct
     9481 tcgcccacgg gcccgatgcg gagtcggtcg cggcacgcta cgtcgaactg ctgcgccgtt
     9541 gggcctccga tcaccggcgg cgcggggcgg cccgcatcca gtacaggccg atgcccgccg
     9601 gcacggctga accctcccag gggattgtgg cgaaacagct cggagccgtc gagatctcct
     9661 ggacatagac tccccgcccc aaggtcgtcg cggggtacgg ggaattgcgc accacccaac
     9721 tcatcaggga ggtaattgtg tccgtccagt tcgaagacgc aacggcgacg tcgcgcccgc
     9781 agaaggcagg ccatgaaggg gacttgaagg gctgggatct ggatgtctcc atcgtcgagt
     9841 ccggcccttc ggccgaccgg ctcatccgga tgaccgacga cggttgcggc cagacctgcg
     9901 agtccgcctg ctcagcgacc tgcccgtaat aggcagtccg gaatcctaac cgcggtgtcc
     9961 ggccgacttg gccggacacc gcccgccgat gggagtgccg gtgtacgagt acgtcgatgc
    10021 cgccatgctg cgggccgtgg cctggccgcc gggtcaccag gtccggtcat ggcccgatcc
    10081 gaccgcaggt gcggcgtcct ggcggacgtg gctgaagcag accctgcgca tacccggctt
    10141 cgcaaccgcg ttggatcagg ccagtcccac actggggcac cgcgtacggg acatttgcgg
    10201 cggcaagcaa ctgccggagc ccgccgtgtg gaaggcggtg ctggccgtca cgcgctatct
    10261 gctgcgcgct tcgagccggg ccaccccgtt cggcctgttc gccggggtga tgcctgcccg
    10321 gatcgctgag gtgccgactg tgcacatcgg cgccgggcac cgagccgtcg ccatgccgga
    10381 cgccgcgtgg ctgaccgcgg tgatcgaacg attggaagtc gaatccgcgc ttctgccgcg
    10441 cctgacggtt caagcccacg cgctcgtggt cgagaaggag ggccacctga ttctcaggca
    10501 ccgcggcgac ggcagcttgg gcggcccccc agcccacgtc cgggtccgcg ccaccatacc
    10561 cgtcaggtcg gccatggacg cggcgcggca acccatccgt gcggtatccc tcgcgtccaa
    10621 actggccgcc gacttccccc acgtcccctc cgacgtgatt gacaagctgc tggtggacct
    10681 gaccgcccag cgcctcctga tcacgaacct gcgcggcccg atgacaacga cagatccgct
    10741 gggccatctg ctagatgtcc tcaaggcagc ggaggttgag gacatcacca ccgtggccga
    10801 catcgccgcc cagctacgcc agatagctga cggtttagcc cggcacaaca ccacctccac
    10861 ccgagcgcga gagcagcgcg cccagctcac cagcgcgatg cagcacctcc acccctgctc
    10921 caggccgccg ctcggtgtcg acctgcggct caagggagag gtgacgatcc cgcatgaggt
    10981 ggctgccgag gccgctcggg ccgcgacggc actggtacgg ctggctcgcc gccccttcct
    11041 cagccgcgcc tggacccgct ggcacggccg cttcctggaa cgctacggcc cgcgcgccct
    11101 ggtgccggtc ctggaggctg tggacgacac tggccttggc tacccggagg gcttcctggg
    11161 tgggccaccc gccgaggcaa atggctcgct gactgagcga gatctgaaac tgctggcgct
    11221 cgcgcagaac gcagcgctgc gccgccaggg cgagatcgtt ctggacgact ccatgatcgc
    11281 cgacctggcc gccgcaggcc ccgagatgcg cgtccagccg accacagaac tgaccgtgcg
    11341 cgtccacgcc gccagcgccc gagacctgga gccaggggag ttcaccctcg cggtcaccgg
    11401 agtgtcgcgc accgccggca cggtcaccgg caggttcctt cacctcctcg aacccggtga
    11461 ccgcgagcgg atgacgaagg cgtatgcagc tgcggccacc gcgaccgagg gcgccttgcc
    11521 catacaggtc tctgcacccc cgctgtacgt gggcgccgag aacgtcgcgc gggctcccct
    11581 ggcgatgccc gccgtcctta cccttggcga gtgccacgag cacaccgaca acaggcgggt
    11641 gctcctggaa gacgtcgcgg tcaccgcgga cacacaccgc ctctacctga tctcgcagac
    11701 catgcgccga ccgctggagt tcgtaaccct caatgcggtg gagccaaccc accgcacgca
    11761 tccgctcgtt cggttcctca ccgaggccaa caactcgatg agcgtcccgt gcacgaactt
    11821 cgactgggga gcggcgacga gcctgccgtt cctccccgcg ctgcgctacc gacgcacgat
    11881 cctggctccg gcacgctggc ggctcacggc cgatgaactg gccgaccgtg aggcagacgg
    11941 agcgcagtgg aaccgtgccc tgaccgcgtg gcgggaccaa gtggccgccc caagcactat
    12001 ctatgccggc gacggcgacc agcgcatccg cctggacctg accgaacctg cgcaccgggc
    12061 gctactgcga gcacaggtgc aacgcgacgg ggtcgccgtg ctccgcgcgg aaacggcccc
    12121 tgacgcggga tgggtcgacg ggcgcgccca cgaactcgtc atccccctcg ccttcaacgg
    12181 cgagcccgga ccggcaccac agtggctcga tagtgggaag accgtcgggc gtgagcatgg
    12241 tcatctcccc ggttgcgacg ggcgattcct cgtgaagctc tacggccacc ctgaccacta
    12301 cggcagcatt ctcacccgtt tccttccgca cctgctcacc gaactgggca gcaccgtgcg
    12361 gtggtggttc ctgccctaca gcgacccgaa cgaccatctg cggctgcgtc ttatcgtgcc
    12421 gaccgaccgc gccgcgagta cccccggcgc gatcggcgcc tggactcaga ggctgcgcca
    12481 ggctgggttg atctcccgag tgcagtggga caccgatttc cccgaaaccg cccgcttcgg
    12541 aggcgtccag gcgatcgacg ctgctgaggc gtacttcgcg gcggactcca aggccgccgc
    12601 cgcacagatc acctacagct cgacgaaagg cggccctgac gcacgggccc tgacggccgc
    12661 cagcatgctc gacctcacga ccagcctgat cgggaacccc gccgaagcaa tgtcctggct
    12721 gatcgaccac gcacagacca ccagcacacc tcccgcccgg gacttgtacg accaggcggt
    12781 caccctgggg aacccgaacg accgctgcga tctggcccgg cagcccgacg gcgagcagat
    12841 cctcgcccgc tgggcccagc ggcgcgaaac tctggctgcc tacaaggccg tgctcgacac
    12901 ggcgggcacg gccagcgcga ccgcgctgct gccagaactg ctgcatctgc accacacccg
    12961 catagccgga ctcgacctga aggcagaagg ccaatgcctg cacctggccc gcgccgcagc
    13021 gttgagctgg accgcacgag gtagaagcgg ctcatgagac cgataccgca ggcgttgacc
    13081 gccgcagaca tcctcgccgc ggcgctggcc gacccgtgca ccgcctgggt cgcagcaccc
    13141 ggtaagcgag cgtgggcgca atcgctggcc ggtggcgcag ccgggatcgc cctgctccac
    13201 atcgaacgtg cccgcaccgg tcgtggcgac tggaacaccg cacacgcctg gttatcccag
    13261 gcagcctccg aggacctcac cgccgcctcc aacgcaagcc tctacctcgg ggcccccgcc
    13321 ctggccttcg ttctgcgcgc cgccgcaggc tccaccggcc ggtaccgaag cgcgctggag
    13381 aaactgaacg acgccaccat cgcggtcacc cagcggcgac tggcacaggc ccacgcccgc
    13441 atcgatcgag gcgaacgccc cgccatgaag gagttcgacc tgatccgcgg actcgccggg
    13501 ctgggcgcct accacctcgc ccaccaaccg caccacaaga tcaccaccga tgtgctgacc
    13561 tacctggtgc gccttaccga tccccttccc aaacagggcg acctccccgc ctggtggacc
    13621 gacgtctccc ccaatggcga gccgaccgcg ggcttccccg gagggcacgg gaacttcggg
    13681 ctggcacacg gcatcggctc agccttatcc gtgatgtcac tggcgctcct gtacggcctg
    13741 gatgtaccgg agatgaccga cgcagtcgca cgaatctgca cctggaccga ccggtggcgc
    13801 caaggagatg acaccagccc gtggtggcca ggcttcatct cgatcgagca ggccactgac
    13861 gggcatatcg acctggcact gcggccccgg ccatcctggt gctatggcgt cagcggcacc
    13921 gcccgcgccc aacagttggc cggtctggca ctgggcgagc ccgcacgcgt gcaggccgcc
    13981 gagaacgcca tccttgcggc tctgcgcgac ccgatccaac tagacctgct ccccgagatc
    14041 ggcctgtgcc acgggacggc cggactgctg cacaccgcgt ggcggatggc cgaccagaca
    14101 acgaaccccg cgatcatcgc ggagctgccg cgcgtaaccg atcgcctgat tgccgtgctc
    14161 gaccgtttcg accacgagcc cgaactgctc gatggcaccg ctggagcagc cctcgctctg
    14221 cacaccgccg gcaccgcgac cgcacccgta tcgcgctggg acgcctttct cgccctggcg
    14281 tgatcacact ggagacgtct gatggacaac tcgcccgcgt ggcaccaggt caacatcgcc
    14341 ttccccgact ggcaccgtgc cgagcaaacc gccctggccc acctcacccc cctcctgtgc
    14401 accgccgagg acgaaggcgc gataggtacc tggttcctca tccgcaaacg cccgtgctgg
    14461 cgcgtgcgct acctgcctgc ccccgacacc cacgtccgca tcggccgaga gctggaggcg
    14521 ctgacagtcg cagggcacat cgccacctgg acacctgcca tctacgagcc cgaagtgcac
    14581 gccttcggtg gcgccgaagc gatgatggtg gcccaccgcc tcttccaccg cgacagccgt
    14641 ggcctgctga cctacctcca gcatgaggac ggaaccgcgc gcggccatcg ccgggaaatg
    14701 tccctcatgc tgtgcagcat cctgatgcgg tcggccggcc tggactggta cgagcagggc
    14761 gacgtctggg cgagggtggt cgcccaccga ccactgcccg ccgccgacca gagcaacacc
    14821 ggccgactgc acgctgccgt gcaccggctg atcaccgtgg acacagagga ccagctcagc
    14881 caggaggggc ccctggccca cgccgcggga tgggccagtg cctacaccgc cgccggacac
    14941 gagctggccc acctcgccgc ctccggagcg ctacaccgcg gcctacgcgc catcctggcc
    15001 caccacctgc tcttcgcctg gaaccggatc ggcctgccct acgccaccca agccgccctc
    15061 gcagccaccg ccaagtccgt gatcttcggc cccgatccca ccacagaaaa cagcgccacc
    15121 gcagtgaaca tcggcatcaa caccacgccc agcggcccgg cctcggcacc ccgctgaacg
    15181 cgtcatcacg ctccgcctac cccgggggcc ccatggaccc gcacggaccg atagcccaac
    15241 gcttcccact cgtcgcccgc gcccgccccg cctgcctacc actgccccaa cgcgtgcagg
    15301 gactggtcga ccttgccgag agcgcagaac gccaggccga ccaaggattc gcctcggccg
    15361 tctacaacca gtcggcgctc atcgcgtctg acctcaacct ccccgaactc gcggggaagt
    15421 tgtgccacca gcacgccgat gcctacctgc acgcctgccc attgcccggc aagagtgcca
    15481 tccgcgggct agaacccatc gtgaacctgg cccgcttgca gatccgtgca ggaaaagccg
    15541 acgacggtcg acggcacctc ctcaacctct acgaagccgt cagcacaggc acagccgcac
    15601 aattcggcga tatcgcccta cccgcacacc tcaccgccac gccggacgac cgccatgaag
    15661 tccgcgcctg gctgtggaca gtcctcctcg ccgatggcac gagaaccctc acctccaagg
    15721 ggcgctggga cgaggcacta acccacatcg aggaacaccg cggcgtgggc aagcggatgc
    15781 tcgacggacg acaagtcgcc gtcctcgccg cactcgtcgc aggcgaccca gcaggcgccg
    15841 tagatctcct cgaagagacc acgcccggcg aaccctggga acaggccgtg accgcgtgcc
    15901 tcaccgcact atgtcatcgc gccgccagcc aaccggccgc tcaccgcacg cacaccctgg
    15961 cgaacatgta cgccaagctg gagcctgcac gcggcatggc cgtcttcgat gctcgcctcg
    16021 gactgacgat cttggacgtc atcggcagcg accaggagcc cgtcacgcac cgagtcgtcg
    16081 acacgttgta cagccggaca acgacactga acgacggaca cgccgcccgc gagaatctgg
    16141 cgcacccctt gttcaccact ctcgtcaccg gcaaacagca gaagaactgc caagacatcg
    16201 tggacgcgtg cgcgctcggt gctggaaaac tccccgacga gctgcatgac caactcgcca
    16261 tggcgctgcg tacgagcgac cgcaccatcc ggaaaggtgt caccagtaaa tagccccgct
    16321 cacggccgga gtggcttccg cgtgagcaaa ttgagcgaga acgaccaagg tcggcggccg
    16381 gtgtaacagc tcacgaccac ctgtgcctca gatccccccg cgccgcgtgc gagccatcta
    16441 cagcaatggt tcagctgagg gagcttccgg tgcttcatgg tgctgctgga cgtccgtgac
    16501 agtgcggttg gcgtacagag aagcgggctg tggcttctgc gatggctcct gggcctcttg
    16561 cccagcgacc tgcgtccccg tacgccggga cagcgcctct cggagtccgg cttctctgta
    16621 ggcggcgccc cgggcggtgc ttcgggcctt cgtcgcctcc ccccggacgc tcttagcggc
    16681 ctggttgtcc ttgttctggg cacggcgcag gaggacggtt ttgtcgcgcc ccagtgtctc
    16741 tgcttcggcg atcacggcct cgtgctcctc ggcgggaccg gcaagggagc aaagctcctg
    16801 aagacggtcg tgcaatgcct ccagttcacg cgcggcctcg atgcgctgtt gctggagcgt
    16861 tccgcgttca gcctcggcgt ggacacggtc gtcaccgcgt agtacgggac ggccgaaccg
    16921 gccggtggcg gtcaactgat agtcaagctg gtgcagtcgt tcttccactt cgcgctttgc
    16981 gtgagtgtgc tgggcgacca cgtccgtgag ggtacggatc tcgcagatcg cctcggcgcg
    17041 tgcggtgagg tcctggtgcc tccggttgag ggcaagcacg ttcggtcctg ttcccgctgc
    17101 ggcttgttgt tcggcgcggt cggctactgc ctccgccttt tcggctgccg tacgggtggc
    17161 gcgggcggcc gtggcagcct tgcgaatcgc gtcgtgcaga gccacattgc tgaggtgtgc
    17221 gtacgggcag ccagtcgtgg gggcggtttc cgttgctgag gccgacggcg cgggtcgctc
    17281 cgtggtgctc ggggtggggc ggtcctcggg ctgcggcgcg tcttccgggc cgtccgcctc
    17341 gtacgggtcg ccagttccgg gagcgcgggg ggtcggcaga tcggctaccg cctgtcggac
    17401 gtgggcgggg accgcggccg tcggaagttc ggtgaggatc atgcgctctt cggtgccggt
    17461 ctcaacctcg cggatgaggc cggcgacagc acggtctagc tgttcctggt cggtgagcgc
    17521 ctctcctccg cgggcacggt cggcgtcggt ttcgtagacg gacagcggga ggaagaggtg
    17581 ggactccttc ttgtctcggc tcatcatcgt gtagagggca ttggcctgcg cgccggggcc
    17641 gtagaccagg gtttcctgaa cgctgaggcc ctggctctta tggccggtga tcgcgtagcc
    17701 aagactcagg ccgccctggg cgatgtagtc cgcatcaacc cattcggcgt ggtcttcgtg
    17761 gccgtcgacc gtcttgactc gccactcgac gagaacacgg cgttcgtcgt ccactgcgcg
    17821 gacgattccg cggagcccgt tgagcacgtc ttcgttcgca ccgcggctct tcttggcgcg
    17881 gtagtcgttg acgcgcagga ggacctggtc ccccacagag agggtcagtt cacgtccacc
    17941 ggcgagcgca taggtgtgct cggggccgat gagatcgccg gtggtcttgc gcagggcccg
    18001 ggctccgagg ttgagctctt cgacgatctc gttcgtggcg gccagcatca gcagctgctg
    18061 cacggcagtg tggtcgtcgc tgtgcgcgga gcgcttgtcg gcccagatgg tgagcatcgc
    18121 agcgagcgtc tcgtccttgt tagcgagcgc gtgcacgcgg cccgtgccgg cgaaggtccg
    18181 cagcgattcc acgcgccggt cgtcgcgcca cagctggagc gcgcggcgtt cgacggcgtc
    18241 cttctgccgg aagttctccg tcagcctcag accgcccacg atgcggtgga ctgcgccgaa
    18301 gtggccgccg acgcccggcg agtgcaactg cttggggtcg ccgatgccga cgaccttcgt
    18361 gccggtcttc gcggcgtgtt cgaggagttc ggcgatatcg cggtcatcgc acatggcgtc
    18421 ttcgtccacg accagaacgt ccacaccggc aagccctcgc ccgcccttgc ggatgcccat
    18481 gagccaggag gcgagggtgc gggaggtgat cccggcttcc gccttgaggt tggcggcggc
    18541 gacggccgcc gtgctcgctc ccgcgattac caggccctgg gcctcccatg cctgccgggc
    18601 ggcgtccatg agcgtcgtct tgcccgcgcc cgcgacgccc tcgacagagt caatgccgtg
    18661 tccagcggtg aggagccgtt cgaggacggc gcgctgctcg gcggagaagg ggaagccctg
    18721 ctgggcctcg actgtggaca gggtcatcac gaccgtgtcg ccgctgacga cggcggactg
    18781 ttcgttcagg cgccgggtgg tctcagtgac gatcagcgct tcggcggcga cgatgtccgc
    18841 ggtcgtgtac cggtcggcgt gcgcgtagtg ctgggcgccc cgggggttga gcttgacggc
    18901 gtacccggcc tgctggagca cggagttggt gagcttctcg gcttcggcgg cggtaccgat
    18961 cccgttcggg agcgcgtcaa gcacggccgc gatggcggcg gcgtgcgtga attccttgga
    19021 gtggctggtg aggccggtct tcgggtcgaa gacgatgctg cacagctctt ccaggctcgg
    19081 gttgagctga tcgacggatt cgccgacggc tccggtggtg atggcgtcgg ggtcgtcacc
    19141 ggcggcgcgt ccttcggcct gccagtacgc gcgcaggacg tcatcctcga cgcctgcggc
    19201 ttcgccgttc ttggcggcct tggaggcggc ggaggcggcg gtgcgttcgc gcagggtggc
    19261 gctgtcgtag tcgagtccga gtttgctgag cagttgacgg atctggctgt cgcgcttgct
    19321 gaagagtcgg atggtggctt cggggatggc ggcaatttcc catgccccgg tgcgttcttc
    19381 gcggcggaag ctgatgccgt agcggtcgcc gagttcgcgg cggatgcggg cgttcatcag
    19441 ggactgggtc gctcgggtat ggcgatgaat gtcccggccg cctgcggcca cggtggacca
    19501 ttgcccgtca tcgcccttgg ccatgttggc cagagtgaag tgcaagtgga agtgggggtc
    19561 gccatagggc gcgccgccga ccggccgggc cgcgcggtgg atcatcagcc acccggagaa
    19621 cccgctggtt ccgatgacgt cggcggactg gccgtcgccg tgacgaccgc gcatcccgta
    19681 ggcggtccag ctttggaggg cctcgatggc ctcgcatccg gcggaggtga agatgtcctc
    19741 tacctcggcg gccaacttcg gcggggcgta tgcgaggaat gctgacttgc tcttggccag
    19801 gtccaaggtg acgtcggtgc cccggttgcc gacttccacg cggccttccc gcatggcggc
    19861 cttgatttct tccgcgtccc agacctgctc cggagcgata ccagcggcct tggccatggc
    19921 gatggcttcg cggacgtcca tgggcagatc gcgaagccga cggccgcctt cggtctcggt
    19981 ctgctggtaa cgccgtttca tggaccggga gtcgaacagg tccgtgggct gctgccccgt
    20041 cgcgcgggcc ttctcctcga cggcatgcag gagtgcacgg gcgtcgagtc gcccgccggc
    20101 ctcggcgaga agtgccttct ccagggcctg ttcgccgtag agctcgacgg cgtcaatgcc
    20161 gacggcgccg gcgagtttga gcagggtgga ggcgggtacc ttgtgggctt cgccaaaccg
    20221 ggtcagttgc cgctccatgg tggcgaaggc ggccttcttg cgctgagagt cgagcagtga
    20281 atccggcttc acgccgcgct cggcggcact gcggcggatg gcccggacca ggggggccgc
    20341 agacagcttg gcggccgggg cgatggcgag cttcggttcc accagggtct gcccggtgcg
    20401 cgggtcctcg ccgcgcatga ggcgtcgagc agcttggaat tgctcgggcg tgagggtgct
    20461 gccggggacg atgtcgaact cggctaggcc gttcccgatc cacatcagcg ggcgttcgct
    20521 cgcgttcagg tggtagtcga cctgtccgtc ggctgccggg gcgggggcaa tggtctcccc
    20581 gtagagttcg tgggcgtcga gccctgctgc ggaggcgact tcgacggcgt cgaatgtagt
    20641 gaaccgggcg gtcttggcgt tcctcaactg ggcgcgggcg cggaagaatg ccttcttggc
    20701 ctcggtggag ccgaggagtc tggcgacgct ggttccagct tcttcggcct tggcctcgat
    20761 ggcggccacg agcggggcgg catcgacggt ggcggctttc ccgcagccgt ggcctccggt
    20821 caggcggtac tcggtctgct cgtccgacga gccgatcacg gttgcccacc ccaccggctc
    20881 gcccaccccc tccggtcagc ttcggtcgaa ttcagtcatc ttggccgatt gtatcgtcac
    20941 gaagtgacga taccttggtc ctctaaattc aagatcatga tcaacgaggg cgaacctcgg
    21001 gcactcggag cggcctggtc gctcctgcgg atcaggctcc tggagcctga tgtcctgttg
    21061 gactgttacc tctgtgcgag gcgcgcgggc tgaggcgccg tacgcgttga ggcggtatga
    21121 cgatccgatg tcggtgtagt acctgcgcgg ggctgtgtcg ttggcccgcc tatggagcac
    21181 accccgtatc cggcggcttc ccgccggttc gccgagttgt cgggcccgta ctggatggcc
    21241 tcggactccc cggcgtacgg agtcgacgcg gaaggccggt tcggaccggg acgtcagact
    21301 ccgcccccgc aaccgggcga acggccggag ggaggagcgg gctcccgaca ggcggggggc
    21361 tcgtagccgc cgatatgtcg ccctgctgtc gggtcgagcg gtcttggttg ggccctgccc
    21421 gacccgcaag cgcctggtga catgacgaag gtccccgctc cgggtcggag cggggacctt
    21481 cgtcatgctg gccgtgtggc tcggccgacg gctatgtgtt caggggccac tcgccgaacg
    21541 gcaccggcgc ctgacctcgg gcttcgcgaa cggcttcctc cgtaccgcac gtggtgcaga
    21601 taaagacctc gcggtcggtg gtcagacggg aacgtgcggg ccgttcaccg agcgggccgc
    21661 cgcagcgcgg acagcgggtg tcgggcacgg gtcactcctc ggggtgctcg cgagcggagt
    21721 tgaggatgag gttccaagtc gggcgggagt aggtcttctc cgtctgcccc tgaagctgcg
    21781 ggatcagttc ggcgttcttc gccccggggt tcgccgcaat ggcctgccgt gcgagggtca
    21841 gccgctcgtc tccttggtac gggtaggcca gtccgcggcg gccggtgggc cgtccgccgg
    21901 cgtgcccgcg gcccttgcgg tccgcgaggt actgccacag cctccaacgc ttccacttcg
    21961 gacgccgccg ggtcggtagc tcgtcccagt cgtcgggcgc gggccacccc tcgggcgggt
    22021 tcttgacgta gtgggagacg gtggtggaat cggcgaaccc gcagaccttc gcagcttcgg
    22081 cggggccgac catctcttcg gggtcgccgt cgagcttcgg cgggttggtg gtgctggcgg
    22141 cggcgcgctg ccgctgaagc tcgtggtgcc acgtcgccca tacgtcgccg tcccagtgca
    22201 tgacgccgtc gatggtgtcc gcgacgggcg ggtgcccgtt gttctcccgg tcggtccaga
    22261 ggttctgaag cgtcggctcg ctgatgccgt ggaccttgcg caggtccgcg cgtgagtaga
    22321 gcgtgcggcc ggtcttgcgg gacacggtcg cctcctgttc ttggtcgggg tcgtgaccgc
    22381 tcggcacggt cactggatgt cgtccgggtc cggggccggc gcccacgtac gactgcccgc
    22441 cggttcgagc cgggtgaggg tggctatgtc ggccaggggg acggcggcgg cccagtcggc
    22501 gcggcctggg tggtcgacgg ggaggttgag cacgagatgc cggccggtcg gggggaagtc
    22561 ctcgacgatg acgaagctgt cgccggggtc ggcgccgatg ctgttacccc tcgtgagctg
    22621 ggcgatgtcg ccgggctggg gacagtcggg gtgtcggtcg catagcatgg tggggttctt
    22681 tctggtgaga gaacatcgac ggccagcgcc ttgttgccct tgtgcgctgg ccgtcatctg
    22741 ttgtctgggg tgcgtggcgc ccgtgggacg cacggccggt cggaggttgc ccgctccgct
    22801 gacggcggag taattaaacc acctttgggt tgagcggggc ggggccctga tccggaggac
    22861 ggcggtcatc agaagagagc cccttgatct gtagggcgtc ggccccggtc gatgggtggc
    22921 cgggtgacgc ggagttcgta gcgggggcgt cccgtgtacg gcggggcgtg agcttcgcgg
    22981 cggtagcggc gccacgccac gacgggggcg ccctggtcga tccagcccgc cgggtactgg
    23041 gaggtgagct gagcccagcg gctccggctg cgcgggacgg cccaccggtc ctcgaccgtg
    23101 gtgatcggcg gcagcgcccg ccagccgggg aaacagtggt cgtgcgcgtc ctccaccgcc
    23161 tcgttgtcac cgtccccgaa cccgttgccg gagtgcacgg ggccttccca ctcgcacgcg
    23221 agacacccgc cccggaactc ctgctcgtcc ccccggcggc cggtcggccg gctgcgggag
    23281 agcagggtcg gggcgtggtg ttcgggcggg tccagctcat ggccgaggtc gctgtacgcg
    23341 ccgccggggt gtccgggctg aatgtgccac gcctgcccgg cgctcccggg tgactggcgc
    23401 gtccgcgcgt tgcgcacccg ccagtagtac gtctgccgtg cccgtgctcc ggtcggctcg
    23461 gcgacggtcg cggtcatgat ggcccacccc cggcggcggc gagcacttcg cgcagaggat
    23521 cagcgagtac ggcctgttcg tccggggcgt cgaggaatcg ggacccgtac gcgcggcgca
    23581 cggcccggcg ggcgtcctgg tggcggtcga gctccgggta gtacggcgat cggtcgagca
    23641 cgtcatagcc gtgctgggtg agcacggcgg agatgagcga ccggacccgt accgggtcga
    23701 gggcggtgag gtcggtttcc cccggggccg cgaggagtac gcggatcagc tcggccgcgg
    23761 tgagccgggg ttgaaggggg acgccgactc ggtggacgcc gtcccggctg ggggtggcgg
    23821 ctcctcggcg gctcggcgtc ctggtggtgc tgcgggcttc tgtcgtctcg tccatcgtgc
    23881 tggccttcga tgactcggga tgctgtcggg cgtcgggtgt cagaacaggg cgtgttcggc
    23941 gcgggcggcg gcggtgcgga acgcgtgggc ggcgtcggcg gcggtgcggc cgggctcggc
    24001 gctccaccgg tcgatggcct cgcggtgcag ggctttggcg gcggcggggt cgtcggcgtc
    24061 gacggggtga ccggtgaggg tttccgcgag gatgccgaac gcctggtcgc gggcgcggtc
    24121 gatgcggtcc cagtcgtacg tccggccggc ggctccccgc ccgtggccgg ctgcgacttc
    24181 gagggcgccg cgcggccagc acggcaacgt ggccgtacgg ccgggaccgg cgaacagacg
    24241 ggggccctgg tggatgccga cgtgttcgat gtggcgagcg gcccattgca ggatcgcggc
    24301 gggggtgtcc gcgatgacga tgctttcggg ggtgtggcgg gtcggcacgg tgctgtcctt
    24361 cgggagggcg ggggcggcgg cgcgctgccg ccgccgcccc cggtggggct gctagtggta
    24421 ggcggtgatc agtcggcgga ccttgtcctc tccgatgcac ccgcccttgt gacggcgcgc
    24481 gctcggcggc tctccgttgc gaccgcgcag gtggctccag aacttcgggc cttcccacgg
    24541 gcacaattca cagctgagga accagtggtt atcgctgccg gggaacccgg tgaggactgc
    24601 ccgccagtgg tgggcccgga gtcccgcgaa cgcgatctgg gcgccctcga tgttgcgatc
    24661 gttgaccggc atccgcgggt gcaggagagg caccggcccg cacaacggtg tgggggcctc
    24721 ggcgagcacc tggtccaggg ggacggcgcc gatccgaccg gcggcgtact gctccgcgag
    24781 atgggcggcg gccatctcgg tgccgggtgt ccccttcggc gggcggcgga ggttgcgttc
    24841 gccctcggtg gtgacgacga accagtcccg gtgccacctg taggcgcggc cgatgacctg
    24901 gtcatcgccg atgatcacgg ggtatcggca ctggatgtcg ggggcgccga cgcggtacgt
    24961 cgggacggtg gtggtgccct cggtcgcggg gacgatgagc ctgcccgctt cggtgtcggt
    25021 gacggtcgcg ggtcgttcga ggagttgcgt ggtcatggtg gtgccctgtt ctggtgagag
    25081 aggggcccgc cccagggcgc tcggccgccg gggcgggcgg gggcgtggtt acgcggcctc
    25141 ggccggggcc tgaggggcgg cggtccattc acggcgc
//
