LOCUS       NZ_CP047146            20969 bp    DNA     linear   CON 30-JAN-2024
DEFINITION  Streptomyces sp. GS7 chromosome, complete genome.
ACCESSION   NZ_CP047146
VERSION     NZ_CP047146.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GS7
  ORGANISM  Streptomyces sp. GS7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9067183)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Multiple polyene macrolides produced by antifungal Streptomyces from
            gut of Macrotermes barneyi facilitates the termite-fungus mutualism
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9067183)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-DEC-2019) State Key Laboratory of Microbial
            Technology, Shandong Unversity, 72 Binhai Road, Qingdao, Shandong
            266237, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-NOV-2019
            Assembly Method                   :: SPAdes v. Nov-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 05:53:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,019
            CDSs (total)                      :: 7,925
            Genes (coding)                    :: 7,616
            CDSs (with protein)               :: 7,616
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 107 of 309
            Pseudo Genes (incomplete)         :: 258 of 309
            Pseudo Genes (internal stop)      :: 29 of 309
            Pseudo Genes (multiple problems)  :: 79 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:40:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6752627
            Orig. end                         :: 6773596
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047146.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jinfeng Ni.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20969
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="28"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20969
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20969
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10969](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10969
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(769..784)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.09"
                     /tool="antismash"
     gene            1087..1887
                     /locus_tag="GR130_RS29350"
                     /old_locus_tag="GR130_29350"
     CDS             1087..1887
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965440.1"
                     /locus_tag="GR130_RS29350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29350"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_159507506.1"
                     /transl_table=11
                     /translation="MTTSTLTKPAAADTGSTGPYAARIHHVSKSFGRPGAQQHVLDDIS
                     IDVAPGEFVCLLGASGCGKSTLLGLVAGLDKPSAGSIETPGGRPALMFQEHALFPWLTA
                     GRNIELALRLRGVPRAERRTEAERLLELVRLKGAYGKRVHELSGGMRQRVAMARALAQD
                     SQLLLMDEPFAALDAITRDVLHDELTRIWQETNLSVLFVTHNVREAVRLAERVVLLSSR
                     PGRVAREWQVDIPQPRRIEDSAVADLSIEITEQLRGEIRRHGQH"
     gene            1874..2944
                     /locus_tag="GR130_RS29355"
                     /old_locus_tag="GR130_29355"
     CDS             1874..2944
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536913.1"
                     /locus_tag="GR130_RS29355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29355"
                     /product="ABC transporter permease"
                     /protein_id="WP_159507507.1"
                     /transl_table=11
                     /translation="MASTETTSQSAAGAPGDDSAGPSAGAPTDRTTDGATGAPPDSAAH
                     TPATAPPAAPADASTTDAPDPQTGSAAGDLAGLEAGLDALDSAVVSRQPWLRTAVSKAF
                     PPLVAVLIVLALWQLAYHFQLKPHYLLPSPLDVYRSLQQKWLEGTLLNFVWTSVSRGAL
                     GFVASVAIGTPLGLIVARVKPVRAAIGPILSGLQSLPSVAWVPAAIIWFGLSDATIYAV
                     VLLGAVPSIANGLVSGVDQIPPLYLRAGRTIGATGLTGVRHVLLPAALPGYLAGLKQGW
                     AFSWRSLMAAELIVNAPDLGTGLGQLLEQGRELQDMSWVLAAILLILIVGIGIELLIFA
                     PIERRVLRSRGLLVKS"
     gene            2949..3719
                     /locus_tag="GR130_RS29360"
                     /old_locus_tag="GR130_29360"
     CDS             2949..3719
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574329.1"
                     /locus_tag="GR130_RS29360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29360"
                     /product="sirohydrochlorin chelatase"
                     /protein_id="WP_159507508.1"
                     /transl_table=11
                     /translation="MNQRPTLLVIAHGSRDPRHAATVTALRARVRKLRPGLRVEVGYLD
                     FNAPRVPRVLERLSAEGVRNVVALPLLLTRAFHAKSDIPAVLREATARLPRLTVHQADV
                     LGPSPLLTGALERRLEEAGLRPGDHRTTGIVLASAGSSDPEAIAAIAQTAREWQRTAQW
                     CAVRPAFASASLPRTADAVRALRAEGIQRVAVAPYVIAPGFLPDRIAAGAREARADILA
                     PVLGPAPELARLLLHRYDQAVRAGARGDLTALAA"
     misc_feature    3799..3819
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.36"
                     /tool="antismash"
     gene            3968..>4240
                     /locus_tag="GR130_RS29365"
                     /old_locus_tag="GR130_29365"
                     /pseudo=""
     CDS             3968..>4240
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_039638715.1"
                     /locus_tag="GR130_RS29365"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29365"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLPEQARQLPAELARIDAYLDDERFIARWRGIFAERLVRPSIPLE
                     TLLRLLYLKHRYQLGYETLCREVADSLSWPRFCGIPLTSPVPHPTT"
     gene            complement(4259..4630)
                     /locus_tag="GR130_RS40020"
     CDS             complement(4259..4630)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS40020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_201305282.1"
                     /transl_table=11
                     /translation="MDHHDEKAHGVRITARGPRAAIEIEGKRLDPGSLSGYTISHQEGE
                     PPHVVLHVENGDAVEFEGLARVAIASPVVVEPTAAEFLAAIDAEELERAVLARPDLGTS
                     PYSLTKAMLTQLGEWARGA"
     gene            complement(4934..6259)
                     /locus_tag="GR130_RS29370"
                     /old_locus_tag="GR130_29370"
     CDS             complement(4934..6259)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS29370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_29370"
                     /product="hypothetical protein"
                     /protein_id="WP_159507509.1"
                     /transl_table=11
                     /translation="MASSASAVSWAGVAAFVVCLLVRKVAPYPRWDLLACLAVSGGATV
                     AWWRVARRPTGARPEKRAGHARWWPGRRGGLVALALTILAMPLLLLMTSAAATTPELAA
                     IVHGGPVLSCVTVQEIHSTSHNQSRNFTEYTSTVSVALPDGRRGTHLTTESVTTSHPLK
                     KGDRVWALHSSTGATPGAILSPSHDELHSLLNGRVSAYEAVLLALWGCFTAALAALDLR
                     EGTSLRHLNADLAAGRSHMLRVRIAGPAAGFHFPYPGRTGKPTRRRQLSPSLRLTSPDG
                     GSRDLFLDRCLDPVPLAEALDGLQGWLYWTPRPNGQLGWTEPAVLVLDDGRYALGATPD
                     GPPPDANAGAPLGEPVTHPLPSPKPARAVGPYILWQPHIHKPGVIAFGFAFLSVCLIAA
                     GIGYGNSTALGTCLATAALGPIIGLLLIGRQRTRYLGSLQGE"
     gene            complement(6274..7317)
                     /locus_tag="GR130_RS29375"
                     /old_locus_tag="GR130_29375"
     CDS             complement(6274..7317)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013021.4"
                     /locus_tag="GR130_RS29375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29375"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_159507510.1"
                     /transl_table=11
                     /translation="MAEEVYEAGLDIINPGGDPDALRTAAKGWRDLHENLQTMFRDLDH
                     EVKRTLDSGWHGPAADSFAEHWRNLDAAMQKSLPQLPEAAKSLDEAADAIEEINHEIHE
                     IYLEIGISIGISVGMSFLTMGFSAAAGAARAAQLAARAAKLAKTLGTILRKVGEAFKTV
                     SRLAKEHRFLKNVLVNWASNTGSTVMANGLSGQDTNLGEAVWQGGLSAVAGTGPGLGVA
                     GKLGGMKGAIRGGAVGNIVGGMAVDGAKTALGTDVSGNEFAADIIINGITGGAGGAAVH
                     GANTHLPPGREGPHFPVDGIINGGIYGAGGVAGQPLKDAMTGAKEESEKNVAPGDPGKK
                     SVRDVFG"
     gene            complement(7332..7583)
                     /locus_tag="GR130_RS29380"
                     /old_locus_tag="GR130_29380"
     CDS             complement(7332..7583)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091174.1"
                     /locus_tag="GR130_RS29380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29380"
                     /product="hypothetical protein"
                     /protein_id="WP_236573635.1"
                     /transl_table=11
                     /translation="MESYTKEFRAKTDAEVIDKGFGVLTESEEVTSAYIEMSTDMVESL
                     NALRQHLDHISQGLRTVQQNATASDESLAAGFDRGRQA"
     misc_feature    8007..8022
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.6"
                     /tool="antismash"
     gene            8402..9019
                     /locus_tag="GR130_RS29385"
                     /old_locus_tag="GR130_29385"
     CDS             8402..9019
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS29385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_29385"
                     /product="hypothetical protein"
                     /protein_id="WP_159507511.1"
                     /transl_table=11
                     /translation="MSTQVNIHGNPQEGAVEGSGATSKWRRRLTRLGVYGLFAVLAGTA
                     ATATAAPAAQSRAVSVAPVSITCRNGTGTVVKTDNDPGKPVMYQATGTCSVTGTENGKA
                     SGTATFSINKNNCVNATTPVTGTIAWPDGTHSTVTATVVWAATAGKGITASISSGSITS
                     GAFAGTVVSGTATAAQQVEVNCVTSGTFDGATGSGSGAVTGS"
     gene            9126..10025
                     /gene="uppS"
                     /locus_tag="GR130_RS29390"
                     /old_locus_tag="GR130_29390"
     CDS             9126..10025
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /inference="COORDINATES: protein motif:HMM:TIGR00055.1"
                     /locus_tag="GR130_RS29390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29390"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_268977943.1"
                     /transl_table=11
                     /translation="MNTGCTVRREQSYRAEAPSPDTAVISPCSVADNPLAAPPPTRSTP
                     PVPDHIAIVMDGNGRWATRRGLTRTQGHAAGAKALIQVVEGAVEIGIRHLTVFAFSTEN
                     WCRPAVEVGFLMTLMRSTLRKHLQRLHAHAVRVRHVGRRTGLPPDLISEIKAAEQLTAD
                     NDRLTLTICLDYGGRTELVDAARSIAEAAAIGTLDPATLDAQMFARHLYSPELPDVDLF
                     IRTSGEQRISNFLLWQCAYAELVFVDTPWPDFDRHHLRQAVEIYATRNRTFGAVEDPGR
                     STEPSVPRRQPCTSTNEP"
     gene            10001..10969
                     /locus_tag="GR130_RS29395"
                     /old_locus_tag="GR130_29395"
     CDS             10001..10969
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.4"
                     /locus_tag="GR130_RS29395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29395"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_159507512.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.2e-57, bitscore:
                     192.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.4e-42,
                     bitscore: 144.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYLDQRALTRAGIHDPLLRESYEYCRRLLTAIGDGKDIWRGSLLL
                     PPERRPHLWTVYGFARHVDEMSEAAIETGAGRAQFADWCTTAMADLESGHSCEPSVRAL
                     IHTLRTWDLDPTGAQAFLDAYLMDQRVTEYSTFDDLLGYLRLIAVEPFRMVVAVMGPAS
                     RPAGSEAEAVALALYLTNLIRDVAEDQRLGRTYLPLEDLDRFGVTREDLACGRMTPAVR
                     DLVKFQVDRAHALYERGAGLPGLLHPQCRGLVTASLMFYRSYLTEIERRDYDVLSAKPR
                     IGPAHQARMALRLGVPLVMSRARRSASGTGHTWHREGAACS"
     gene            10966..13128
                     /locus_tag="GR130_RS29400"
                     /old_locus_tag="GR130_29400"
     CDS             10966..13128
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.4"
                     /locus_tag="GR130_RS29400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29400"
                     /product="MMPL family transporter"
                     /protein_id="WP_159507513.1"
                     /transl_table=11
                     /translation="MTLGRAAARRSWVFLVVPLVLAVLAAVAASGIHDRLSYGGIIAQD
                     AESNRAAVAVRERIGRGGADVVAIYRNPHHTVDEPMFRRAVEDSLASAPKRTVVSTMTY
                     WSRDLPPLVSKDHHATAVAIMLAGADDTSRVASYHRLRPALRAEGFDIEYAGPVAVVDG
                     VAERTLADVRRAELIAFPLVLALLLLIFRSLVAALLPVVIGGLSIGITLGVLVLLSGTV
                     EISFITVSLVTSLGLALGVDAALFVVGRFREELAGRHSVPDAVTATCATAGRTVFLSGA
                     TMTGIALGFLLFPVGVMQACGVGAAVVIAVSAVLSVTALPAALALLGPRVNAGRLRRPR
                     RKDTVPAEGPWAGLARAVMARPGHYVIGTLLALLALTAPFAHITLGFPDQRTLPADAPA
                     RLASDALRHDFALGGLDTVQVMVTVPQRLDTRDGQRTLTAWAGELVHLPGTGAGLIAAT
                     SQHSAVIYLSHNGSAEDPATRALVRHIRALPPPDGGQVLVGGLSAMAQDTLQLLGRRLP
                     WVLLYIAVFTYVLLLTTLRSVVLPAKALLVNALSLGASFGALVWIFQDGHLTWLVGASR
                     TGYIDVAQPVIMLILLIGLSMDYEFFLLSRIREQYDATGDNTAAVATGLQQSAPVFTSA
                     AAVVMAVSAAFTTSGVTMVKELCVGMFIAIALDATLIRALLVPATMRLLGRANWWLPGA
                     KHRQWGGQEAPAPLKRPASARQSSNP"
     misc_feature    complement(13236..13248)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(13353..13368)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.27"
                     /tool="antismash"
     gene            13611..14039
                     /locus_tag="GR130_RS29405"
                     /old_locus_tag="GR130_29405"
     CDS             13611..14039
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS29405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_29405"
                     /product="hypothetical protein"
                     /protein_id="WP_159507514.1"
                     /transl_table=11
                     /translation="MKQSRLRARIGATAAAAVVLTGGAVALAAPASAKANLIAIDGAEY
                     VAKPKHVIIVDVTYSCDTGETLRIEGVATSTVNKKAVATGTLASGEVTCDFGSHIAEVK
                     LTPKAGAVFHKGDKVKVAVKTLDATNDVYADAEKFAKI"
     gene            complement(14106..14348)
                     /locus_tag="GR130_RS29410"
                     /old_locus_tag="GR130_29410"
     CDS             complement(14106..14348)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS29410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_29410"
                     /product="hypothetical protein"
                     /protein_id="WP_159507515.1"
                     /transl_table=11
                     /translation="MALAAAAAAAAAAAAAAGRSLGFSDQPFWAGRLAALGTVAAPVSV
                     KKLTEERLAVRAPSCGRTPSAPPAAWLRGTAPRVS"
     misc_feature    complement(14628..14641)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     misc_feature    complement(15000..15015)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            complement(15153..15305)
                     /locus_tag="GR130_RS40025"
     CDS             complement(15153..15305)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS40025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_201305036.1"
                     /transl_table=11
                     /translation="MAAARAAEYQAVIDQATQVADAANTASVVRRLRAELRRVGRRDFF
                     PPPRT"
     gene            complement(15687..16814)
                     /locus_tag="GR130_RS41680"
                     /old_locus_tag="GR130_29420"
     CDS             complement(15687..16814)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="GR130_RS41680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29420"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_159507516.1"
                     /transl_table=11
                     /translation="MNPPVMNRIPLRIRLTAIFAAVMALVLAGAGYLTLSRFRESQSEY
                     GSVTGIAHQAQQEALDDLVRELLTALPIVLILATIGAYLLAAAALRPVERMRTQAAAVT
                     EDTPGYRLDVPPSRDEIARLATTLNDMLTRLQTALNHERLFVADASHELRTPLSLLRTE
                     IELALRHPREAAELRAALVSAHEETERLVQLSEDLLLLARTDRRDTTPAGSAVPDLARL
                     LHRVAARLRNGSPGTAVTVGCPDGLTAAVPHDRLERAVTNLIHNAQQHGRGSVEVTARP
                     YEKPAHEMPAHEKQVRIEVRDHGPGFPPDFLPHAFDRFTQADRSRATTGTGLGLAIAAA
                     IARAANGEYGAYNHPDGGAVAWITLPTLPQPPRSA"
     gene            complement(16811..17512)
                     /locus_tag="GR130_RS29425"
                     /old_locus_tag="GR130_29425"
     CDS             complement(16811..17512)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952677.1"
                     /locus_tag="GR130_RS29425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29425"
                     /product="response regulator transcription factor"
                     /protein_id="WP_159507517.1"
                     /transl_table=11
                     /translation="MRILVVEDEPKMRGLLRRALTEEGYAVDVAADGLQALALTDVAAY
                     DAMVLDVMLPGPDGFEVCATLRHRGIWLPVLMLTAKDAVADRVHGLDGGADDYLTKPFS
                     LDELMARLRALIRRGPVERPTVLTAGDLSLDPATRTVRRGDKEIPLTGKEYALLEALMH
                     RPGTVLTRAVLVEHCWDLGTSPGSNVVDAHIKALRDKIDRPYGTRAVETVRGAGYRIRR
                     DGGRTSTHRPS"
     gene            17694..18698
                     /locus_tag="GR130_RS29430"
                     /old_locus_tag="GR130_29430"
     CDS             17694..18698
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014144527.1"
                     /locus_tag="GR130_RS29430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_29430"
                     /product="DUF1259 domain-containing protein"
                     /protein_id="WP_159507518.1"
                     /transl_table=11
                     /translation="MSPRSLTKPAAGTTAALLLVTGAGLLTGCGTQTRSGAAGGTSAVA
                     AQAPSRNPHLQQPVQTKEADWKPVADALGRTGTLMKGTVYRVPLPRQDLKVTTEGVTVK
                     PGLSLGGYATFAKYKHTTMLMGDLVVTEDELPKVTDALQAAGIEQTALHKHLLQQSPAI
                     WWTHVHAMGDPVKLARGLKSALAATSLPPASPPPSTQPPIALDTAGIDKALGRKGTADG
                     GIYKFTVARRNTIDDGEHVLPPALGLTTGINFQPLGGDKAAINGDFVMTAPEVQKVIQA
                     LRKGNIDIVELHNHSLDEHPRLFYLHFWATADGVTLAKALRPALDTTAPAPAS"
     gene            18941..19918
                     /locus_tag="GR130_RS29435"
                     /old_locus_tag="GR130_29435"
     CDS             18941..19918
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS29435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_29435"
                     /product="YncE family protein"
                     /protein_id="WP_201305037.1"
                     /transl_table=11
                     /translation="MPSWPSYCSPAAAASRPGWHCHSAAKEIALPGDSSRFDYASLDPD
                     RGLLFIAHLGASQVIEVDVHKGRVVRIIDGLSGVHGVLVVPALHRVYATATDANQVVAI
                     DEATGTVLHRSPTGDYPDGLAYDPVHGTVWTTNESGGSETVVDAATGATRGNVPLGGEA
                     GNVAYDPTTRQMLVDVQTGNELAVIDPTTLHITRRVPLPGCDHDHGLILAPTNRLAFIA
                     CDGNARLLTVDLTTWHITGTDQVGDDPDVLAYDPAARHLFVAAESGWVTTADNHDRHLT
                     ITGRAHLADGAHVVAVDPTTHLSYYPIPHGPGGHPALLVYRPGP"
     misc_feature    19952..19967
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.61"
                     /tool="antismash"
     misc_feature    complement(20167..20182)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.44"
                     /tool="antismash"
     misc_feature    20662..20677
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.3"
                     /tool="antismash"
ORIGIN
        1 tgggcgcctg cggctacggc tcccaggccc cgaaggacac cgccgccacc atcgccccca
       61 agggccccaa ggtggacgga ctggaccagg tcaagatcgg cttcttcggc aacaccaccc
      121 acgccacccc gctgatcggc ctccagacgg gccagttcca aaaggcgctg ggcggcacgg
      181 cgatcaagtc cgcggtcttc aacgcgggcc cggccgagat cgaggcgctc aactccggcg
      241 ccatcgacat cggctggatc ggcccctccc ccgcgatcaa cggctacgtc acgtcgcacg
      301 gcaagagcct gaggatcatc gccggttcgg cctccggcgg cgtctcgctg atcgtcaacc
      361 ccaagaagat caagagcctg gacgatctca agggcaagac gatcgccacc ccgcagctgg
      421 gcaacaccca ggacgtcgca ctgctcaact tcctcgccca gaagggctac aaggtcgacg
      481 ccaccagcgg caagggcgac gtcaccgtcc agcgcatcga caacaaggtg accccgaccg
      541 cgttcacaca gggcaccatc gacgccgcct gggtccccga gcccaccgcg tccaagctcg
      601 tcgccgcggg cggcaagtcg ctgctggacg agaagaagct gtggaaggac gggaagttcg
      661 tcatcacgaa cgtgatcgtc tcgcagaagt tcctcaagga gcacccgaag gccgtcgagg
      721 cggtgctgcg cggctcggtg gccaccaaca cctggatccg gtcccacccc gacgaggcgg
      781 tcaaggcact caacgccagg ctcgccgacc cgcagatctc cggcaaggcg ctgcccaacg
      841 acgtcatcga ccccgcgttc cagaacgtcg acgtcaccga cgacccgctg gccgccaccc
      901 tccaggaaga ggcggaccac gccgtccagg cgggcctgct gaagaagccc gacctcaagg
      961 gcatctacga cctcaccctg ctgaacaaag tgctcaaggc cgaggggaag ccgccggtcg
     1021 acgacgccgg cctcggcagc aactgacccc cgccccggca ccgcagtccc ccaggaggtg
     1081 acaccgatga cgaccagcac gctcaccaag cccgccgcgg cggacaccgg atccaccggt
     1141 ccgtacgccg ctcgcatcca ccacgtctcg aagtcgttcg gccgccccgg cgcgcaacag
     1201 cacgtactgg acgacatcag catcgacgtc gcccccggcg aattcgtctg cctcctgggg
     1261 gcctcgggct gcggcaagtc caccctcctc ggcctcgtgg cgggtctgga caagccgtcc
     1321 gccggcagca tcgagacgcc cggcggccgg cccgcgctga tgttccagga gcacgcgctg
     1381 ttcccgtggc tcaccgcggg ccgcaacatc gaactcgcgc tgcggctgcg cggggtgccg
     1441 cgcgccgagc ggcgcaccga ggccgagcgg ctgctggaac tcgtacggct caagggcgcg
     1501 tacggcaagc gggtccacga gctgtcgggc ggcatgcgcc agcgcgtcgc gatggcccgg
     1561 gcgctcgccc aggacagcca actgctcctg atggacgagc cgttcgccgc gctcgacgcc
     1621 atcacccgcg acgtactgca cgacgagctg acccggatct ggcaggagac gaacctgtcg
     1681 gtcctcttcg tcacccacaa cgtccgcgag gccgtacggc tcgccgagcg ggtcgtgctg
     1741 ctgtcctccc gccccggccg ggtcgcccgc gagtggcagg tggacatccc gcagccgcgc
     1801 cgcatcgagg actccgcggt cgccgacctt tccatcgaga tcaccgaaca gctccgtggg
     1861 gagatccgcc gccatggcca gcactgagac caccagccag tccgccgccg gagcacccgg
     1921 agacgactcc gccggtccat cggccggcgc gcccaccgac cgcaccacgg acggcgccac
     1981 cggcgcgccg cccgattccg ccgcgcacac accggccacg gcgccccccg cggcaccagc
     2041 cgacgcgtcc accaccgacg cacccgaccc ccaaaccggt tccgccgccg gcgacctcgc
     2101 cggtctggag gccgggctcg acgccctgga ctccgcggtc gtctcacgcc aaccgtggct
     2161 gcgcaccgcc gtctcaaaag cgttccctcc cctcgtcgcc gtgctgatcg tgctcgcgct
     2221 gtggcaactc gcctaccact tccagctcaa accgcactac ctcctcccaa gcccgctcga
     2281 cgtctaccgc tcactgcagc agaagtggct cgaaggcacc ctgctcaact tcgtgtggac
     2341 cagcgtctcc cgcggcgccc tcggcttcgt cgcctcggtc gccatcggaa cgccgctcgg
     2401 gctgatcgtc gcccgggtca agcccgtacg cgccgcgatc ggaccgatcc tgagcggcct
     2461 gcagtccctc ccgtcagtgg cctgggtccc agccgcgatc atctggttcg gactgagcga
     2521 cgccaccatc tacgcggtgg tgctgctcgg cgccgtcccc tccatcgcca acggcctggt
     2581 gtccggagtc gaccagatcc cccctctcta cctgcgcgcc ggccgcacca tcggcgcgac
     2641 gggcctcacc ggcgtccgtc atgtgctgct gccggccgcg ctgcccggct acctcgccgg
     2701 cctgaagcaa ggatgggcgt tctcctggcg ctccctgatg gccgccgaac tcatcgtcaa
     2761 cgcccccgac ctgggcaccg gcctgggcca actcctcgaa cagggccgcg aactccagga
     2821 catgtcctgg gtactggccg cgatcctgct gatcctcatc gtcggcatcg gcatcgaact
     2881 gctcatcttc gccccgatcg agcgccgggt gctgcgcagc cgcggactcc tcgtcaagag
     2941 ctgacaccat gaaccagcgc cccactctcc tcgtcatcgc ccacggcagc cgcgacccgc
     3001 ggcacgccgc gaccgtcacc gcgctccgcg cgcgggtccg gaagctgcgc ccgggactgc
     3061 gcgtcgaggt cggctacctc gacttcaacg cgccccgggt gccccgtgtg ctggagcgcc
     3121 tctcggccga gggagtacgg aacgtggtgg cgctgccgct cctcctcacc cgcgcctttc
     3181 acgcgaagtc cgacatcccc gcggtactgc gcgaagccac cgcacgactg ccccggctca
     3241 ccgtccacca ggccgatgtc ctcggcccct cacccctcct gaccggcgcc ctggaacgcc
     3301 gactggaaga agccgggctg cggcccggcg accaccgcac gaccgggatc gtcctggcct
     3361 cggcgggctc ctcagacccg gaggcgatcg cagcgatcgc tcaaaccgcg cgggagtggc
     3421 agcgcaccgc ccaatggtgc gccgtgcgac ctgcgttcgc ctccgcatcc cttccccgca
     3481 cggccgacgc cgtacgagcc ctacgagccg aaggcatcca gcgagtggcc gtcgccccgt
     3541 acgtcatcgc acccggcttc ctcccggacc gcatcgccgc cggcgcccgc gaagcccgcg
     3601 ccgacatcct cgccccagtc ctcggccccg cccccgaact ggcccggctg ctcctgcacc
     3661 gctacgacca agccgtccgc gcgggcgccc ggggcgacct gacggcgctc gcggcctgac
     3721 cggcgaccgg cctgaccagc ccggccggca cggcctcggt ggcccgaccc gtccggaccg
     3781 ggccacccac agccccaccg gcatagcgct agctacgtgg ccctgaagaa gtctggatcg
     3841 gtgttgggtt gacctctggg gagagctgtt gagggctgcc ccttgaccgc gacagtggag
     3901 gcgggtcgtt gtagccgggg gtggggcgat gttacgtgtc ccgggagttc aagacccgtg
     3961 gtgagaggtg ctgccggagc aagcgcggca gctgcctgcc gagttggcca ggatcgatgc
     4021 atatctggac gacgagcggt tcattgcccg gtggcgcggg atattcgccg agcggctggt
     4081 gcggccgtcg atcccgcttg agacgctgct gcggctgctg tatctcaaac accgctacca
     4141 gctcgggtac gagacgctgt gccgggaggt cgccgactcg ttgagctggc cgcggttttg
     4201 cgggatcccg ctgacgtccc cggtgccgca cccgaccaca cgccgcgccc cctccccctc
     4261 aagcgccacg agcccactcc ccgagctggg tgagcatcgc cttcgtcagc gagtacgggc
     4321 tcgtgcccag gtccggcctg gccagtaccg cacgctccaa ctcctcggca tcgatggccg
     4381 cgaggaactc ggcagccgtt ggctctacga caaccgggct ggcgatagcc actcgggcga
     4441 gcccctcgaa ctcaacggcg tcgccgttct ccacgtgcag aacgacgtgc ggaggctcgc
     4501 cctcctggtg gctgatcgtg taaccgctca ggctcccggg atccaaccgt ttcccttcga
     4561 tctcgatggc tgcccgcggg ccccgagcgg tgatgcgcac accgtgtgcc ttctcgtcgt
     4621 ggtgatccat tcagccaacg gtaagagggc tgtcggacag cgcgaggcac tccgcactgc
     4681 ggcggttcga cacagagcgc aggctcgtca cgtcagcgtt cccactggca ctttcctggc
     4741 gaccaggcgc cgggacatcg gccaaacagg gcccacggtt tatgcaactt gtgtggcacc
     4801 ctcgtgacac ttcgcatgga ccgagttcgc gatacacgag gcgcacctcg cgcgcgtagt
     4861 cgctgccgta gaccagtgtc cctgttaccg gttggcacgg tgtccggctg ccagatagcg
     4921 gggcgcagcc gggtcactcg ccttgcaggc tgcccaggta gcgggtgcgt tggcggccga
     4981 tcagcagcag gccgatgatc ggcccgagcg cggcggtcgc caggcaggtg cccagggccg
     5041 tgctgttccc gtagccgatg cctgccgcga tgaggcagac ggacaggaaa gcgaatccga
     5101 aggcgatgac gcccggcttg tggatgtgtg gctgccacag gatgtacggg cccaccgcgc
     5161 gggccggttt cgggctgggg agcggatggg tgacgggttc gccaagaggt gcgcccgcat
     5221 tcgcgtcagg gggcggtccg tcgggtgtcg cgcccagtgc gtaccggccg tcatcgagga
     5281 cgagcacggc gggttccgtc catcccaact gtccgttggg ccgcggcgtc cagtacagcc
     5341 agccctggag gccatccagc gcctcggcga gcggtacggg gtcgagacag cggtcgagga
     5401 acagatcccg gcttccgccg tctggcgagg tcaggcgcag cgagggggaa agctgacggc
     5461 ggcgggtggg tttgccggtg cgcccggggt aggggaagtg gaagcccgcg gcggggccgg
     5521 cgatacgtac ccgcagcatg tgggagcgtc ctgcggcgag gtcggcgttg aggtggcgta
     5581 gggaggtgcc ctcccgcagg tcgagcgcgg cgagtgccgc ggtgaagcag ccccacagtg
     5641 ccagaagcac ggcctcgtac gcggagacgc ggccgttgag gagcgaatgc agctcgtcgt
     5701 ggctcgggct cagaatggcg ccgggcgtcg cgccagtgga ggagtgcaga gcccagaccc
     5761 tgtcgccttt cttgagtggg tggctagtgg tgacgctctc cgtcgtcagg tgtgtgcccc
     5821 gccgcccgtc cggaagggcc acggagaccg tggaggtgta ctcggtgaag ttccgcgact
     5881 ggttgtggct ggtggaatgg atctcctgga cggtgacgca ggacaggacc ggtccaccgt
     5941 ggacaatcgc agccagttcg ggggtggttg ctgccgccga agtcatcagc aggagcagcg
     6001 gcatggccag gatcgtgagc gcgagggcga ccaggccacc gcgccgtccc ggccaccacc
     6061 gcgcgtgccc ggcccgtttc tccggacggg ccccggtcgg ccgccgcgcc acgcgccacc
     6121 acgccacggt ggccccgccg gagaccgcca agcaggccag caggtcccag cgcggatagg
     6181 gcgccacctt ccgcaccagc agacacacca caaacgcggc gacgcccgcc caggacactg
     6241 ccgaggcgga cgacgccacg cgaccccgtt ccttcacccg aaaacgtccc tcacgctctt
     6301 cttgcccggg tcgcctggcg cgacgttctt ctctgattct tccttggcgc cggtcatcgc
     6361 atctttgagt ggctggccgg ccaccccacc ggcgccgtag atgccgccgt tgatgatgcc
     6421 gtcgaccggg aagtgcggcc cctcgcggcc gggcgggaga tgggtgttgg cgccgtgtac
     6481 ggcggcgcca ccggcgcctc ctgtgatgcc gttgatgatg atgtccgcgg cgaactcgtt
     6541 gccgctgacg tccgttccca gagcggtctt cgcgccgtcg acggccatcc cgccgacgat
     6601 gttgccgaca gctccaccgc ggatagcgcc cttcattccg cccagtttcc cggcgacacc
     6661 gaggcccggg ccggtaccgg cgacagcgga gagtccgccc tgccagaccg cttcgccgag
     6721 gttggtgtct tgtccggaca ggccgttggc catcaccgtg gacccggtgt tgctggccca
     6781 gttgaccaga acgttcttca ggaaacggtg ttccttcgcc agccgggaga cggttttgaa
     6841 cgcctcgccg accttgcgca agatggtgcc gagagtcttg gcgagtttgg cggcgcgggc
     6901 ggcgagctgg gccgcgcgag cggcccccgc ggctgccgag aagcccatgg tcagaaagga
     6961 catgccgacc gagattccga tagagatgcc gatctccaga tagatctcgt ggatctcgtg
     7021 gttgatctcc tcgatggcgt ccgcggcctc gtcgaggctt tttgccgcct ccggcagctg
     7081 cggcaagctt ttttgcatcg ccgcgtcgag gtttctccag tgctccgcga aggaatccgc
     7141 cgccggacca tgccagccgg aatccagggt ccgcttcacc tcgtggtcca ggtcccggaa
     7201 catggtctgg aggttttcgt ggagatcccg ccagcccttg gctgccgtac gcagggcgtc
     7261 cggatcaccg ccggggttga tgatgtccag gccggcctcg tagacctctt ccgccaccga
     7321 ctcgtcaccg ctcacgcctg acgcccccgg tcaaagccgg ccgccagaga ctcatccgac
     7381 gctgtggcgt tctgctggac cgtgcgcagg ccctggctga tgtgatcgag gtgctgccgc
     7441 agagcgttca gcgactccac catgtcggtg gacatctcaa tgtacgcgga ggttacttcc
     7501 tcggattccg tgaggacgcc gaatcctttg tcaatcacct cggcgtcggt cttcgcccgg
     7561 aactcctttg tgtagctctc caagtccgac ccatgagtat cgaagctttt cgctaacccg
     7621 gagatggccg cggcatctac taagaactca tccttagaca ggattcactc ctcactgctc
     7681 acgaaacata cctacggcat atcaatcaag attttccgca attaatgaat tctaagggtt
     7741 tgtcccgtaa tccctggtgg atcagcgcac ggcgtcagat gcggtgtatc gcaaggcgga
     7801 ggggcatccg gataccggac gtatccggat gttccgacaa cgcagcgagg cgccgtagct
     7861 gtcgtcgtgc gcccgccaag gattacggga caacccttag cgcggcttgc ctcggtgtcc
     7921 gcggggctgt tcgtagcctg tcgccgtttc cacacacccc gcaccccacc tcatatcgaa
     7981 cgcgagaatt ccgtttcagc gttccatcga atcaatgtgc gacaaatgcc caccctatgg
     8041 cgtcgcccta acgtcggtaa agaatagtcg tgcaatccca tctaacgcct tccgcttcgg
     8101 cgggttccgc agtacagtgg ccgcaatacg gcaggcctgt acggcgaaag cggcctcggc
     8161 ggattccgtg gcagcgttcc gcatctagcg gactgtggcg catatccctt cgcggagccc
     8221 ttttccggaa gtcacccttt ctcgtcacgc atccacagct ccacttttct tgggattcac
     8281 ggagcggcga gatgcgtcca ctcgggctga tggcagtcca ctccccatta ttttccgcgc
     8341 actgcggcat ggaattactt ctgccccgac gcaggtccaa ttcctcttgg aaggaggaga
     8401 cgtgtcaact caagtaaata tccacggaaa tccgcaggaa ggcgccgtcg agggttcggg
     8461 cgcgacgtcg aagtggcgtc gccgtctcac ccgccttggt gtctacggac tgttcgcggt
     8521 gctggccgga accgctgcga cggccacggc ggcgcccgcc gcgcagtcgc gagcggtcag
     8581 cgtcgcgccc gtgtccatca cctgccggaa cggcacgggc accgtggtga agaccgacaa
     8641 cgaccctggt aagccggtca tgtaccaggc aacgggcacc tgctcggtca cgggcacgga
     8701 gaacggcaag gcgagcggca ctgccacgtt ctcgatcaac aaaaacaact gcgtgaacgc
     8761 tacgacaccc gtcacgggaa ccatcgcctg gcccgatggg acgcacagca ccgtcacggc
     8821 caccgtggtg tgggccgcta ccgccggaaa gggaatcacg gccagcatct ccagcggctc
     8881 gattaccagc ggtgccttcg cgggcaccgt ggtgagcggt acggccacgg ccgctcaaca
     8941 ggtcgaggtc aactgtgtca ccagcgggac cttcgatggg gctaccggct ccggctccgg
     9001 ggcggtgacc ggtagctgac ggttccaacg ggcctgtgcc gggcgcgtct tgcctgcccg
     9061 gcacgggctc cggcagtggg cccgccctcg acaaccgccg gggactgcag cggtatgtct
     9121 ccctcatgaa tacggggtgc actgtgcgac gggaacagtc atatcgagcc gaggcaccgt
     9181 caccggacac cgcggtgatc agtccgtgct ctgtagcgga caatcccctg gcagctccgc
     9241 ctcccacccg ctcgacgccg cccgttcccg accacatcgc catcgtcatg gacggaaacg
     9301 gccgttgggc cacccgccgg gggcttacgc gcacccaagg ccacgcagcc ggcgcaaagg
     9361 cgctgataca ggtggtcgaa ggcgccgtcg agatcggtat ccgccatctg acggtattcg
     9421 cgttctccac cgagaactgg tgccgtcccg cagtcgaagt cggtttcctg atgacgctga
     9481 tgcggagcac cctgcgcaag catcttcagc ggctgcacgc ccatgccgtg cgcgtcaggc
     9541 acgtgggacg acgcaccggt ctgcctcccg atctcatcag cgagatcaag gcagccgagc
     9601 agctgaccgc cgacaacgac cggctcaccc tgaccatttg cctcgactac ggaggccgga
     9661 cagaactggt cgacgcggcc cgcagcatcg ccgaggccgc cgccatcggc acgctggacc
     9721 cggcgaccct cgacgcccag atgttcgccc gccacctcta ctcccccgaa ctgccggacg
     9781 tcgacctgtt catccgcacc tccggtgagc aacgcatcag caacttcctg ctctggcagt
     9841 gcgcttacgc cgaactcgtc ttcgtcgaca caccgtggcc cgacttcgac cgccatcacc
     9901 tacggcaggc ggtggaaatc tacgcgaccc gcaaccgcac cttcggagcc gtcgaggacc
     9961 cgggccgcag caccgagcca tccgtaccca ggaggcagcc gtgtacctcg accaacgagc
    10021 cctgacccgc gccggaatcc acgatccgct cctgcgcgag tcctacgagt actgccgccg
    10081 actcctgacc gccatcgggg acgggaaaga catctggcgc ggcagcctgc tgctgccacc
    10141 ggaacgacga ccgcacctgt ggactgtgta cgggttcgcc cgccacgtcg acgagatgtc
    10201 tgaggcggcc atcgaaaccg gggcggggcg agcacagttc gctgactggt gcaccaccgc
    10261 gatggccgac cttgaatccg ggcactcgtg tgagccgagc gtgcgcgcgc tgatccacac
    10321 actccgcacc tgggacctcg accccacagg cgcccaggcg ttcctcgacg cctatctgat
    10381 ggaccagcgc gtcacggagt actccacctt cgatgatctg ctgggctacc tgcgtctcat
    10441 cgccgtcgag ccgttccgga tggtcgtcgc tgtcatggga cctgcgagcc ggccggccgg
    10501 gtcggaagcc gaggcggtgg cactggccct gtacctgacc aacctgatcc gtgacgtcgc
    10561 cgaggaccag cggctcggtc ggacctatct gccgctggag gacctggacc ggttcggcgt
    10621 cacgcgtgag gacttggcct gcggacggat gaccccggcc gtcagggacc tggtgaagtt
    10681 ccaggtggac cgggcccacg ccctctacga gcgcggcgcc ggcctccccg gtctcctgca
    10741 cccccaatgc cggggactgg tcacggcctc gctgatgttc taccggtcct acctcaccga
    10801 gatcgagcgg cgggactacg acgtgctgag cgccaagccc cggatcggtc ccgcacacca
    10861 ggcacggatg gcgctgcgcc tgggcgtgcc cctggtgatg tcccgagccc gccgttccgc
    10921 tagcggaacg ggccacacgt ggcaccggga gggagccgcg tgttcgtgac gctcggccgt
    10981 gccgccgcac gccgtagttg ggtctttctc gtggtgcccc tggtgttggc cgtactggcg
    11041 gcggtcgcag cgtcaggcat ccacgaccgg ctcagctacg ggggaatcat cgcgcaggac
    11101 gccgagtcca accgggccgc cgtggcggtc cgggagcgca tcgggcgcgg tggcgcggac
    11161 gtggtcgcca tctaccgcaa cccccaccac acggtggacg agccgatgtt ccgccgggca
    11221 gtggaggatt cactggcgtc cgcgccgaaa agaaccgtcg tctccaccat gacgtactgg
    11281 tcgcgcgatc tgcccccgct ggtctccaag gaccaccatg cgacggccgt cgcgatcatg
    11341 ctcgccggtg cggacgacac gagccgcgtg gccagttacc accggctgcg cccggcgttg
    11401 cgggccgagg gcttcgacat cgagtacgcc gggccggtcg cggtggtcga cggggtcgcc
    11461 gagcggaccc tggcggatgt gcggcgcgcc gaactgatcg cgtttcccct ggtgctggcc
    11521 ctgctcctgc tgatcttccg cagcctggtg gcggccctgt tgccggtggt catcggtggg
    11581 ctcagcatcg gtatcacgct gggcgtcctg gtgctgctga gcggcacggt ggagatctcg
    11641 ttcatcaccg tgagcctggt gacctccctg ggactggcgc tgggagtgga cgccgccctt
    11701 ttcgtcgtcg gccggttccg cgaggagctc gccggccgtc acagcgtgcc ggacgcggtc
    11761 acggccacct gcgccaccgc cggccgcacg gtgttcctgt ccggggccac catgaccggc
    11821 atcgctctgg gattcctgct cttccccgtc ggtgtcatgc aggcgtgcgg tgtcggcgca
    11881 gctgtcgtca tcgccgtcag cgccgtcctc agcgtcaccg cgctgcccgc cgctctggcc
    11941 ctcctcggcc cgcgcgtgaa cgccggacgg ctccgccggc cacggcgaaa ggacacggtc
    12001 ccggcagagg ggccctgggc cggactggct cgtgcggtga tggcccggcc agggcactac
    12061 gtgatcggta cgctgctggc gctgctggcc ctgaccgcac cgttcgcaca tatcaccctc
    12121 ggcttccccg accagcggac cctgcccgcc gatgcgcccg cccgcctggc ctccgacgcc
    12181 ctgcggcacg acttcgcgct cggcgggctg gacaccgtgc aggtgatggt caccgtgccg
    12241 cagcggctgg acacccgcga cggacagcgg acactgaccg cctgggccgg cgaactagtc
    12301 cacctgcccg gcaccggcgc cgggctcatc gccgcaacgt cccagcacag tgcggtgatc
    12361 tatctgagcc acaacggcag cgccgaggac ccggctaccc gcgcactggt gcggcacatt
    12421 cgcgcgctac ccccgccgga cggcggccaa gttctggtgg gcgggctgtc ggccatggcc
    12481 caggacaccc tccaactgct gggccgccga ctgccgtggg tcctgctgta tatcgcggtg
    12541 ttcacgtatg tgctgctgct gacgacgttg cggtcggtcg tcctgccggc gaaggcactg
    12601 ctcgtcaacg cgctgtccct cggagcctcc ttcggcgcgc tcgtgtggat cttccaggac
    12661 gggcatctga cctggcttgt cggcgcaagc cgcaccggat acatcgacgt cgcccaaccc
    12721 gtgatcatgc tgatcctgct gatcggcctc tccatggact acgagttctt cctgctgtcg
    12781 cgcatccgcg agcagtacga cgccaccggg gacaacaccg ccgcggtcgc gactgggcta
    12841 cagcagtccg ctccggtctt cacctcagcc gcggcggtag ttatggccgt cagcgcggcc
    12901 ttcaccacca gcggcgtaac catggtcaaa gagctgtgcg tcgggatgtt catcgccatc
    12961 gcgctggacg ccaccctcat ccgagcactg ctcgtcccgg ccaccatgcg gctgctgggc
    13021 cgggccaact ggtggctgcc cggcgccaag caccgacagt ggggcggaca ggaggcacct
    13081 gctcccctga agcgcccggc gagtgcgcgt caaagcagca acccgtgagc cgtctggccg
    13141 agcgcgatga gagccggcct cccgaggtcg aaatcaccaa ctggctgcct gcgaagcctc
    13201 cccagcgacc gctgccctgc cggtatcgat tcgcggtgac cgcggcacag acggcggcct
    13261 gtgccgcgcg tccggcctgc tggatccggc gcgaggacat gacgacagtc aggccgtgcc
    13321 ggacctggac gggcaggtac cgctgtgctc tcttgaaaat gacgtgagcg gactatgcgg
    13381 ccgcactcag ttcgaggatg acctcgtagc cgagggcgcc gagtgctttt cgggaagtaa
    13441 gtgcggcaag gccaacactg gcaccaaagt gtcgtatatg cgccggagat atcccctgga
    13501 cggccatcct tgccacctgt gatgatccgt aagcattgct cctgtgcggt tcctgtgaac
    13561 cggcggggca gcgccgtacc tttcgcacca cttctcaggg gggaacaccc atgaagcagt
    13621 cccgtctgcg cgcccgtatc ggcgccaccg cggccgccgc cgtcgtcctg accggcggcg
    13681 cggtggctct ggccgctccg gcctcggcca aggccaacct catcgccatc gacggcgccg
    13741 agtacgtggc caagcccaag cacgtgatca tcgtcgatgt cacctactcc tgcgacaccg
    13801 gcgagaccct gcgcatcgag ggcgtggcca ccagcacggt caacaagaag gccgtcgcca
    13861 ccggcactct cgccagcggc gaggtgacct gcgacttcgg ctcccacatc gcggaggtga
    13921 agctgacccc gaaggcgggg gccgtcttcc acaagggcga caaggtgaag gtcgccgtca
    13981 agaccctcga cgcgacgaac gacgtctacg ccgacgcaga gaagttcgcg aagatctgag
    14041 tgccgggagc tgtccgggcc ggaccgaccg cccggacagc caacgctcag accgccgcac
    14101 cgcccctacg acaccctcgg cgccgtcccc cgcagccatg cggcgggcgg cgccgagggc
    14161 gttctcccgc agctcggggc gcgcacggcg agccgctcct cggtgagctt cttgacggag
    14221 acgggcgcgg cgacggtgcc cagcgcggcc agccgcccgg cccagaaggg ctgatcgctg
    14281 aagccaaggc tgcgtccggc tgcggctgcg gctgcggctg cggctgcggc tgcggctgcc
    14341 agagccaacc gggcggccct gatggggatc cttgaaacca agaatcctca tcaacggttc
    14401 gtcggcttcg tgagccgcgg cggaacgcga taccgaccag cttcgagcgc cggggtagtc
    14461 cggcggctcg atggcgaaat cggagagcag atacgttgaa atggcgatgg gtggcaccta
    14521 ctgccgctcg gcgacgaaca accgatcctg ctcacggtcg tacgccgcgg ccctcatcac
    14581 ccacgcgtac tgcctcgacc agcggcccag cagcgtccgg gatttatgca actcctgtgc
    14641 caccttcgca acactccgcc caggaccaag atcgcggtac acagcgaacg cctcgaacgc
    14701 ctgggaagac tcaccgttct gccgctccca ggtctccgca gcagtccggt ccctcaccgg
    14761 aaaccttctc tctccccacg ccgctattca tcatgcacga gcgacagtca cagctgtccc
    14821 acggagctga ccgtgccacg ggggcgcggt gagccaggcg cgaggcgcgg gcttgtgcgg
    14881 cggaggtgtc atcgggtacc tcgcgagctc tcgttggcgg gggtgccatt gcgctccgcg
    14941 gcctccagca gggcgaaggt gcgggctgac tctcccctgt ctcgcgtccc agcaggaggc
    15001 agaccagaca gtctcattcg cgcgacctat tccggatgcg agatatgccg gattcggtgg
    15061 tgttctccgg gtggcttgcg ctcttcgatg ctgcgctaag ggacttgtcg tccagttcgt
    15121 cggcgagggc gcatacagcg gcgtgtgcgc ggtcacgttc gggggggcgg gaagaagtcg
    15181 cggcggccga cgcgtcgcag ttcggcgcgc agtctgcgta cgacggatgc ggtgttggcg
    15241 gcgtcggcga cctgggttgc ctggtcgatg acggcttggt attcggcggc gcgggctgcg
    15301 gccatggtgg tggccagttc gcgctcctgg gcgtgggtgg cgggctgggc gatccagatg
    15361 gcggcggtgc cgcctgcctc aatggcctcg tcggcgagcc actccagctg ttcgcgggcg
    15421 cgggcgtcgg cgggcagtgc gaccagaccg tcggagagtt gggcgactcc caggcgcttg
    15481 agcttgcgtc agatggcgat gcggggcgag gagggttcgc ggggcatccg gtaggagagc
    15541 aggacccact cgcccgggtc gcgggtcggc cggtcagcgg ccacagcgtg caccgatccg
    15601 cgcatcggac gttgtccggt ccatcgccgc tccccacagt caacccgcac tggatgcaac
    15661 catggtttca tgcggtttgg ggtgcatcaa gcggacctgg gcggctgtgg aagggtgggg
    15721 agggtgatcc atgcgacggc gccgccgtcg gggtggttgt aggcgccgta ctcgccgttg
    15781 gcggcgcggg cgatggcggc ggcgatggcc agtccgaggc cggtgccggt ggtggcgcgg
    15841 gagcggtcgg cctgggtgaa gcggtcgaag gcatgcggga ggaagtcggg cgggaagccg
    15901 gggccgtggt cccggacctc gatgcggacc tgcttctcat gcgccggcat ttcgtgagcc
    15961 ggcttctcgt aggggcgggc ggtgacttcc acggagccgc ggccgtgctg ctgggcgttg
    16021 tggatcaggt tcgtcaccgc tcgttccagg cggtcgtgcg ggacggcggc ggtcagtccg
    16081 tcggggcagc cgacggtgac ggccgtgccg ggggagccgt tccgcaggcg ggcggccacg
    16141 cggtgcagga gccgggccag gtcgggcacc gccgacccgg cgggggtggt gtcgcggcgg
    16201 tcggtgcggg cgaggagcag caggtcctcg gagagctgga cgagccgttc ggtctcctca
    16261 tgggcggaga cgagggcggc gcgcagctcg gcggcttcgc gggggtggcg cagggcgagt
    16321 tcgatctccg tgcgcagcag gctgagcggg gtgcgcagtt cgtggctggc gtcggcgacg
    16381 aagagccgtt cgtggttgag ggcggtctgg aggcgggtga gcatgtcgtt gagggtggtg
    16441 gcgaggcggg cgatctcgtc gcggctgggt ggtacgtcga ggcggtagcc gggggtgtcc
    16501 tcggtgacgg cggcggcctg ggtgcgcatg cgttccactg ggcgcagggc cgcggcggcc
    16561 agcaggtagg cgccgatggt ggcgaggatg agaacgatgg gcagggcggt gagcagttcg
    16621 cgtaccaggt cgtcgagggc ttcctgctgg gcctggtggg cgatgccggt gacggagccg
    16681 tattcgctct gggactcgcg gaatcggctg agggtgaggt agccggcgcc ggccaggacc
    16741 agggccatca cggcggcgaa gatcgcggtg aggcggatgc ggagcgggat gcggttcatg
    16801 acgggcgggt tcatgacggg cggtgggtac tggtgcgtcc gccgtcgcgg cggatccggt
    16861 atccggcgcc gcggacggtc tcgacggccc gagtgccgta cgggcggtcg atcttgtcgc
    16921 gcagggcttt gatgtgggcg tcgaccacgt tggagccggg gctggtgccc aggtcccagc
    16981 agtgctcgac gagcacggcg cgggtcagca ctgtgccggg acggtgcatg agcgcctcca
    17041 ggagggcgta ctccttgccg gtcaggggga tctccttgtc gccgcgccgc accgtccggg
    17101 tggccgggtc cagtgacagg tcgccggcgg tcagcacggt ggggcgttcg acggggccgc
    17161 ggcggatcag ggcccgcagc cgggccatca gctcgtccag gctgaagggt ttggtgaggt
    17221 agtcgtcggc accgccgtcc agaccgtgca cccggtcggc gaccgcgtcc ttggccgtga
    17281 gcatcagcac gggcagccag ataccgcggt gccggagggt cgcgcacacc tcgaagccgt
    17341 ccgggcccgg cagcatgacg tccagcacca tcgcgtcgta ggcggccaca tcggtgaggg
    17401 cgagggcctg caggccgtcg gcggccacat cgacggcata gccctcctca gtcagggccc
    17461 ggcgcagcaa gccccgcatc ttgggctcgt cctcgaccac caggatccgc atcgcaccgt
    17521 ccttcgtccg ccgctgccgc gcacatcgtc gcgcctttca cgatccccgc cgctgatgaa
    17581 ggtggcatga agtcacccga gcgggtcgat cttcatgtcg acttcatccg gggcggcttc
    17641 tctggccaca cagacacctt cgacttcgac aacgatctcg acgaggagtg gtcatgtcac
    17701 cccgttcgct caccaagccg gccgcaggga ccacggccgc gctcctcctg gtgacgggcg
    17761 ccggcctgct gacaggctgc ggcacccaga cgagaagcgg cgccgccggc ggtacgagtg
    17821 cggtcgcggc gcaggcccct tcccggaacc cccaccttca gcagcccgtg cagaccaagg
    17881 aggcggactg gaagccggtc gccgacgccc tcggccgcac cggaacgctg atgaagggca
    17941 ccgtctaccg cgtcccgctg ccccgccagg acctcaaggt caccaccgag ggcgtcaccg
    18001 tcaagccggg cctgtccctg ggcggttatg cgacgttcgc caagtacaag cacacgacga
    18061 tgctcatggg cgacctggtg gtcaccgagg acgaactgcc caaggtcacc gatgcgttgc
    18121 aggcggccgg catcgagcag accgccctgc acaagcacct gctccagcag tcgccggcga
    18181 tctggtggac gcacgtccac gccatgggcg acccggtgaa actcgccagg ggcctcaagt
    18241 ccgccctcgc cgcgacctcc ctcccgcccg cctcgccgcc cccgtccacg cagccgccca
    18301 ttgccctgga caccgccggc atcgacaagg cactcggccg caagggcact gccgacggcg
    18361 gcatctacaa gttcaccgtc gcccgcagga acaccatcga cgacggggag cacgtgctcc
    18421 cgcccgccct cggcctgacc accggcatca acttccagcc cctgggcggc gacaaggccg
    18481 ccatcaacgg cgacttcgtc atgaccgccc ccgaggtgca gaaggtcatc caggcgctcc
    18541 gcaagggcaa catcgacatc gtcgagctcc acaaccactc cctggacgag cacccgcgcc
    18601 tgttctacct gcacttctgg gccaccgccg acggagtcac cctggccaag gcactgcgcc
    18661 cggccctgga cacgaccgcg ccggcgcccg cgtcgtgatc ggctgaggtc ggatcggatg
    18721 cggtgcgacg ctgtcggcgt tgccatccgc gtatccctcg ccgtatgcct cgtcgtcgct
    18781 gtactggacg acccggccgt cccgccgccg ctcgcccccc gtgggcagtg gcgggccgcc
    18841 ctcaccgctt caccgccgac cccggaaagc ccgcacatga tccgtcgtct cagcccccgc
    18901 gctctactgg ccctgatcgt gggcctggtc ctcgctggcg ttgccgtcgt ggccgtcgta
    18961 ctgctcaccc gcggcggcgg ccagccgccc agggtggcac tgccactccg cggcgaagga
    19021 gatcgccctg ccgggggaca gctcccgctt cgactacgcg agcctcgatc ccgaccgcgg
    19081 gctgctgttc atcgcccacc tcggcgcgag ccaggtcatc gaggtggacg ttcacaaggg
    19141 ccgcgtcgta cggatcatcg acggcctgtc cggcgtccac ggcgtgctgg tcgtccccgc
    19201 cctgcatcgg gtgtacgcca ccgccaccga cgccaaccag gtggtcgcca tcgacgaggc
    19261 cacgggcacc gtcctgcacc gcagccccac cggcgactac cccgacgggc tggcctacga
    19321 cccggtacac ggcacggtgt ggaccaccaa cgaatccggt ggctcggaga ccgtcgtcga
    19381 cgccgccacc ggagcgaccc gcggcaacgt cccccttggc ggagaggccg gcaacgtcgc
    19441 ctacgacccc accacccggc agatgctggt cgacgtccag accggcaacg aacttgccgt
    19501 catcgacccg accaccctcc acatcacccg ccgcgtcccc ctgcccggct gcgaccacga
    19561 ccacggactg atcctcgccc ccaccaaccg gctggccttt atcgcctgcg acggcaacgc
    19621 ccgcctgctc accgtcgacc tgaccacctg gcacatcacc ggaaccgacc aggtcggcga
    19681 cgatcccgac gtactcgcct acgaccccgc cgcccgccac ctcttcgtgg ccgccgagtc
    19741 cgggtgggtc accaccgccg acaaccacga ccggcacctc accatcaccg gccgcgccca
    19801 cctcgccgac ggcgcccacg tggtcgccgt cgaccccacc acccacctca gctactaccc
    19861 catcccgcac ggccccggcg gacaccccgc actcctcgta taccgacccg gaccgtgacc
    19921 cccggacacc actcatcaca gtggcgcggg atcgaattcc tgaacgaggg acttcgggcg
    19981 tgccgggtgg tgtcgccctc gcaggtcagc accacccggc ctctcgacgt cccgcatggc
    20041 aacccctggt gcatgatccc ttcccaggcc gctggcagcc gccgaaaacg ccggggtgct
    20101 catgatgtgc cagccaagtg gaggcggtga agcgcgctgc cgaaccctcg ctgttcggcg
    20161 gatgctgaga aggataagca cttgacttca tcgagaccgc ttagctgtcc gtgtccgacg
    20221 gattgtgtgc cgggtcgctg tgccgggtgc gactttcgtc gtcggccgtc gcgaccaatg
    20281 gccggtgccg tgtccggctg aggggcctaa cgtggcggcg tgaatcgtgt ggaatctacg
    20341 gcccctgctg catcggctcg ccaggcactg gcggcgaggc tgcgttcggc gccccgccgg
    20401 ctggccgccc cgggcagggc tctcttcgcc cccgggatgt ggcctccccg gcgcatcgtg
    20461 ggcgaatcgc tgctgagcgt ggtgttcggg ctgctgggag caggtgtcga ggccctgggc
    20521 cacggcggca tggtccagat cgtcgccgtc gggctggcgg ccggactgct gtccccttgg
    20581 cgccgggtgt tgcctgcgac ggtgctgctg gtgaccgccg ccggttccgt cccgttcgac
    20641 ggtttcaccc tgctggtcct cgtcaccgcc tggtcagcgg ggcggcggat cgacggggtc
    20701 ggcaaagcgg tcggcacctt cggcctcgtc tacgtcctca ccctcggcct ggcggtcgtg
    20761 caggagctgc ctcgcttttc actgtcgcac ttgctcgtcg gcgccctctg gctgctggtc
    20821 gcgatcatcg tgcccggcct cgccggccgc tactggtcgc agcgccgtac gctgaccgac
    20881 acgctccggg agtacagcgc ccagttgctg cgcgagcgcg cgatgatcgc cggacaggcc
    20941 cggatgcggg agcgtcagcg catcgcgca
//
