LOCUS       NZ_CP047146            20714 bp    DNA     linear   CON 30-JAN-2024
DEFINITION  Streptomyces sp. GS7 chromosome, complete genome.
ACCESSION   NZ_CP047146
VERSION     NZ_CP047146.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GS7
  ORGANISM  Streptomyces sp. GS7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9067183)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Multiple polyene macrolides produced by antifungal Streptomyces from
            gut of Macrotermes barneyi facilitates the termite-fungus mutualism
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9067183)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-DEC-2019) State Key Laboratory of Microbial
            Technology, Shandong Unversity, 72 Binhai Road, Qingdao, Shandong
            266237, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-NOV-2019
            Assembly Method                   :: SPAdes v. Nov-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 05:53:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,019
            CDSs (total)                      :: 7,925
            Genes (coding)                    :: 7,616
            CDSs (with protein)               :: 7,616
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 107 of 309
            Pseudo Genes (incomplete)         :: 258 of 309
            Pseudo Genes (internal stop)      :: 29 of 309
            Pseudo Genes (multiple problems)  :: 79 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:40:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5455821
            Orig. end                         :: 5476535
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047146.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jinfeng Ni.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20714
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="23"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20714
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20714
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10714](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10714
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            69..1232
                     /locus_tag="GR130_RS23705"
                     /old_locus_tag="GR130_23705"
     CDS             69..1232
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044062.1"
                     /locus_tag="GR130_RS23705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23705"
                     /product="permease"
                     /protein_id="WP_159506564.1"
                     /transl_table=11
                     /translation="MHAVLHALSIAGSMAWEITWALILGFALSAVVQALVRKSTVVALL
                     GDDRPRTLAIAAGLGVASSSCSYAAVALARSLFRKGAHFTAAMAFEIASTNLVVELGVI
                     LALLMGWQFTAAEFAGGTIMIVALAVLFRLLLPSELLREARAQADRGLAGSMEGHAAMD
                     MSVRRPGSFARRLFSPEGFTATAHVFVMEWAAILRDLVAGLVVAGAIAAWVPDSFWRSF
                     FFAGHPLASAVWGPLIGPLVAIASFVCSIGNVPLAVVLWKGGISFGGVVAFVFADLLIL
                     PILHIYRKYYGGRMALFLLGTFYAAMVTAGYVVEFAFRALGLVPDQARARVPMEGVSWN
                     YTSWLNIAFLLLAAALLVRFLRTGGRAMLGMMGGSPATANGHGNHGS"
     misc_feature    93..108
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.78"
                     /tool="antismash"
     gene            complement(1338..1778)
                     /locus_tag="GR130_RS23710"
                     /old_locus_tag="GR130_23710"
     CDS             complement(1338..1778)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014050089.1"
                     /locus_tag="GR130_RS23710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23710"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_159506565.1"
                     /transl_table=11
                     /translation="MSDLRITQPDGDAGFADWRHVHNAVIPTHVLSLDDVRERARRNHL
                     EVAYVGDVLVGCSTVRPPVDDPSTATVIARVLAAHRGRGFGEELYARGLRRARELGAEA
                     VETVVLSSNEDGLRFALKHGFAETERYLLPGDTTPWIDLRLS"
     gene            complement(2033..4180)
                     /locus_tag="GR130_RS23715"
                     /old_locus_tag="GR130_23715"
     CDS             complement(2033..4180)
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523197.1"
                     /locus_tag="GR130_RS23715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23715"
                     /product="xanthine dehydrogenase family protein
                     molybdopterin-binding subunit"
                     /protein_id="WP_159506566.1"
                     /transl_table=11
                     /translation="MTTTTTGRLALVGAVGTAHTRVEGRDKVTGAARYAGEIPFAELAH
                     GWLVLSTIARGRIRAVETAPVLEMPGVLTVLHHGNAPRVDGDYTGPMGPPDPAILVFQH
                     DRVPCAGWPVALVVAETSEQAREAAEALVVRYDEEPHDIAFAAGRPGTYTPADTPRAAA
                     ERQKGDPVAEFAASAVVVDAEYTTPEEHHNPLEPHAAAAHWDDGRLDVVDSNQGSVFVA
                     QELAKLFSLDPGAVRVRSEHVGGAFGSKGTRPHQVLAVMAATVLHRPVRVVLTRRQMFS
                     LVGYRSPTVQRVRLGADPDGRLRALDHEAQNLTSTQREFVERSADPARVMYDADAHHTV
                     NRVVRLDVPTPTWMRAPGEAPGSFALESALDELAEKCGVDPIALRIRNEPAAGPVSGLP
                     FSSRNLLACYEEGARRFGWADRDPRPGIRREGRWLLGTGMAAASFPSGAAPSTASVTAE
                     ADGTFTVRITAADIGTGARTALTLIAADELEVAPDRIRMRIADSDFGPAMIAGGSMGTR
                     SWAWAVTVAARALRGQLALGGGVPPQGITARSDTAELIGALPARERHSFGAQFAEVAVD
                     VTSGEVRVRRMLGTFAAGRIVNPLTARSQLIGGMIWGLSMALHEEAVRDEVSGGHVGAD
                     LASYHFASNADVPVVEADWVDDPDDEDPVGIKGIGEIGIVGAAAAIANAVWHATGTRHR
                     HLPIRPDRVLRATPGPQRPTT"
     gene            complement(4177..5217)
                     /locus_tag="GR130_RS23720"
                     /old_locus_tag="GR130_23720"
     CDS             complement(4177..5217)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027599.1"
                     /locus_tag="GR130_RS23720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23720"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_159506567.1"
                     /transl_table=11
                     /translation="MREFGYRRASDVQGAVALLGAEPEARYLGGGTNLVDLMKTGVERP
                     ALLVDVRELPLDRIEATDTGGLRIGATVTNSDLAAHPEVRRRYPALAQAVLAGASGQLR
                     NMATVGGNLLQRTRCGYFTDVTRPCNKRLPGSGCPAVEGEHRNHAILGASAHCVAVHPS
                     DMAVPLAAFDAAVAYETADGPGELPLAEFYRPVADTPHLETALPAGALITGVTLPPAPV
                     AARSRYRKVRERASYAFAIGSIAAALDVRDGVVHEVRLALGAVASRPWRARQAERLLTG
                     GPASAEAFAAAADAELAAARALPHNGYKVTLMRNLVIAVLSELSQPPAASGASGAATDR
                     SGEAAR"
     gene            complement(5214..5783)
                     /locus_tag="GR130_RS23725"
                     /old_locus_tag="GR130_23725"
     CDS             complement(5214..5783)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982979.1"
                     /locus_tag="GR130_RS23725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23725"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_159506568.1"
                     /transl_table=11
                     /translation="MALSTAGAITLNINGEKHTLPVDHRTTLLDALRERLGLTGTKKGC
                     DQGQCGACTVLVDGRRAVSCLQLAVAAEGREITTIEGVADGARLHPVQQAFLDLDGYQC
                     GYCTPGQICSAIAVIEEHAAGWPSAATADVRPEAGVPPLTADEIRERMSGNLCRCGAYV
                     AIVQAVTRAAADTGRPADAENAEDAA"
     gene            6209..6787
                     /locus_tag="GR130_RS23730"
                     /old_locus_tag="GR130_23730"
     CDS             6209..6787
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601825.1"
                     /locus_tag="GR130_RS23730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23730"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_159506569.1"
                     /transl_table=11
                     /translation="MQRPHGAPLRADAQRNRDRILEVALAELTRAADAPLSAIAKKAGV
                     GQGTFYRNFPDREALVLEVYRHEVQQVCDAAAHLLATQPPDRALREWMDRLAQYAMAKA
                     GLAAALRKAVGTHGTLVGLAHGPLTSAVSLLLAANKEAGTLRPGVTPDDFLLAISGLWQ
                     LDPHGDWQSRAGRLLDLVMDGLRTGAPGA"
     misc_feature    6903..6915
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            7029..7844
                     /locus_tag="GR130_RS23735"
                     /old_locus_tag="GR130_23735"
     CDS             7029..7844
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039441.3"
                     /locus_tag="GR130_RS23735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23735"
                     /product="DUF6424 family protein"
                     /protein_id="WP_159506570.1"
                     /transl_table=11
                     /translation="MNTAPSTHTEHEDEPWTISVADHPPRTDSPQFVASRKLMNELVGT
                     MDDWPFAPGPYQDHHGAGMWLKDTKGWMCIILPLGIEWSAQFCADPAKVDRMRQYALRV
                     IAAFPDTLPGYVSLGYDDGERLLNTPIQTADQVAEWTDSIFNASVPLPAGAHTGVLPTA
                     AGYHHYPKPIVDIDHFRYDDFQLFVTGPKGLPVAVVPVAPRGSGDGRVQVLAAHPRSPY
                     AAHLVAPGPAGRAAGPADAEARAEAWRGAILPADDDVARKAFHEQLQPA"
     gene            7884..8891
                     /locus_tag="GR130_RS23740"
                     /old_locus_tag="GR130_23740"
     CDS             7884..8891
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675796.1"
                     /locus_tag="GR130_RS23740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23740"
                     /product="DUF2278 family protein"
                     /protein_id="WP_159506571.1"
                     /transl_table=11
                     /translation="MPIDFYGVLAGRAVDRRREGSTGTPHYQIHLTDNAGTHYRAAVNV
                     LSQQSPPELLYLADDDFRHPLTQLLPAAGSGWTTLPSRSGSTSLDYIRGNMFVPSSMRV
                     LPADLPGANNDLADLLDHYVQRAIADPTMQVYAFGQRFGPEPSVPDEVFHFLPGNGVHD
                     MHMNQGNSGRFRVDDGVWQDGGLLIHLPAESRWVAVFLAFQSQSWHTDDTTGHTIPTAA
                     PVSGAGAAPLRIVAALVKPAGPAPEAESVTLLNASPAPVELAGWQLADQQGHRLPLPAQ
                     QVAPGATVAVPGGNGFQLADLGGTITLLDPAGINVHGVSYTEEQGRREGWTIAF"
     gene            9092..9664
                     /locus_tag="GR130_RS23745"
                     /old_locus_tag="GR130_23745"
     CDS             9092..9664
                     /GO_function="GO:0003796 - lysozyme activity [Evidence
                     IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0016998 - cell wall macromolecule catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019548639.1"
                     /locus_tag="GR130_RS23745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23745"
                     /product="GH25 family lysozyme"
                     /protein_id="WP_159506572.1"
                     /transl_table=11
                     /translation="MTIKGIDVSSSQPEGYKTSGSDFVFIKITEGTSYTNPKWTGQRRT
                     ARNAGLVTGFYHFARPGPMKPQADYFLSRINLADGDILILDWEDPGVSGTWKDSWLRQV
                     QTSAPGHKTLLYCDRDFWENRDTTSFAGDGLWIAEYNGKPGQPDIRHPWLFHQYTDTPM
                     DTSIGNFKDKAELRSWSRPLVHLGHSA"
     gene            10001..10714
                     /locus_tag="GR130_RS23750"
                     /old_locus_tag="GR130_23750"
     CDS             10001..10714
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999281.1"
                     /locus_tag="GR130_RS23750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23750"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_159506573.1"
                     /sec_met_domain="CDPS (E-value: 1.1e-84, bitscore: 282.4,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTATEIFHVRPYTPHCQVITDEGDHAVIGISPGNSYFTHQRVLS
                     LASWGVENFRQVDLVYTDLHVADMYEALGYPAVDAQRKAVKNLRGVRAKVTAAVAALDP
                     DGTRLRGRPMSALLDIPAYRVIRESLDDRLSTDPAFRGVCDQLVVQFLTSRVLNGQQPT
                     DRQRQVCLDYICAEAPLFIDTPAIMGVPSSLNCYHQALPMADLLYSRGHGLRATRNQGH
                     AVITPAGTLTEGRDQ"
     gene            10711..11898
                     /locus_tag="GR130_RS23755"
                     /old_locus_tag="GR130_23755"
     CDS             10711..11898
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999282.1"
                     /locus_tag="GR130_RS23755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23755"
                     /product="cytochrome P450"
                     /protein_id="WP_159506574.1"
                     /sec_met_domain="p450 (E-value: 6.8e-17, bitscore: 60.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPTLIDFPFSPRGDRLPPEIERLRATPVTRVRTIAGDEAWLV
                     SSYELCKQVLEDPRFSLKDTSAPGVPRQYALTIPPEVVNNMGNITGAGLRKAVLKAINP
                     KADGLTEWMTDHATHLVDGILDYGPPVDLRGQFASPYAEHLHCHILGIPRDDARLLASS
                     LDIAFMNSACPIAGARLNWDRDIAYMTGRLNDPATDGLLAELAALRRDPGYAHLTDAML
                     ATVGVTMFGAGVVSTMGALTMAVFTLLQHPEVWEQLRAEPGKIPAAVDELLRVNLSIAD
                     GLPRLAMEDMQLGDTEIRKGELVLVLVEAANTDENVFPDPLTIDIDRPNAAAHLSFGYG
                     GHYCPAVPLGKKHIETAIEALITRTPGLHLAVPVDQLVWRTRFMKRIPERLPVAW"
     gene            12313..13335
                     /locus_tag="GR130_RS23760"
                     /old_locus_tag="GR130_23760"
     CDS             12313..13335
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537626.1"
                     /locus_tag="GR130_RS23760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23760"
                     /product="DUF1259 domain-containing protein"
                     /protein_id="WP_236573412.1"
                     /transl_table=11
                     /translation="MITGDPQQDIHPQAGSPRRRVLAAAALAPALAAAAPAPARALGPA
                     RVPASAPPGTSRHGLIKPVHTTQSDWASVAAHLGGLGDMKQKTMYHTGFPRRDLRVVSD
                     RVTVKPALALGSHVAFVRYEDGSSLVMGDLVVTEHELQRFCDTLHKHRLAVTALHKHLL
                     AQRPSVWWLHVHGHGHDPAHLARGLRAAFDGTGTPLPLPPGIENPVDLDTDGVEEALGA
                     KGSVDGEIFKCIFVRRERITDGDLVLPPGLGSTTALNFQPLGDGRAAVSGDCAMIAEEV
                     QKVLAALRRAGAELVELHNHGLTDEPRLFFVHFWAVGDAVRLARALRPAMDATNVIAAG
                     "
     gene            complement(13615..15591)
                     /locus_tag="GR130_RS23765"
                     /old_locus_tag="GR130_23765"
     CDS             complement(13615..15591)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014144270.1"
                     /locus_tag="GR130_RS23765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23765"
                     /product="glycosyltransferase family 39 protein"
                     /protein_id="WP_159506576.1"
                     /transl_table=11
                     /translation="MASTTSTATASAAHTGGGLLARTGTRRQDREVRPVYARFGLPVIL
                     VVAAVLFTWDIQHSAFHAFYAETARSMAESWKAFLFGAFDPGSSITIDKLPGFLWPQAL
                     SARIFGFHPWALTLPQVIEGLLSVVFLHRAVRRWAGEHAALLAAGAFALTPAIAGLFRT
                     AVEDPAFTLLVILAADATLRAAREARVRPLLAAGVWVGLSFQAKMLEAWAVLPALGLLY
                     LISAPTALRRRLAHLTVAGAMCLAVSASWVLLVAVTPAKDRPYIDGTTNNSAVSQVVGY
                     NFLNRFSSIHISAEKTGSVAVSTMAGTAPATPSGHSRPTAALWVKMFGPSLASQVGWLY
                     PTAALAAVCGLVWRRGRPRTDPLRAGFVLWGVWLVTYFLVFSAGSIGGHTYYMGVVAVP
                     LAALFGAGTVQFWRAWRRGGRARAWALPAAVAGTVGWSAFVSVQFPTFLPWLTPVAITL
                     GAGALALLALSRKDAGGTRRRMALLGLGAGLAAMLLPSAAWASTVLNPVYGHSGMGSTG
                     PVAVRRHTAPRHPAPDARKAAKSPDGASLDEKQRRLLAYTRAHQDGADYVFATTSWRTA
                     SPYILAAGAKVLPMGGFTGTVPTPTEAAFRHLVATGRLRYVLLGGPGTTEGRAIAPWVR
                     AHCPREPGTTAQLYRCSPSSAGR"
     misc_feature    15670..15684
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.21"
                     /tool="antismash"
     gene            complement(15773..16075)
                     /locus_tag="GR130_RS23770"
                     /old_locus_tag="GR130_23770"
     CDS             complement(15773..16075)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016905822.1"
                     /locus_tag="GR130_RS23770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23770"
                     /product="hypothetical protein"
                     /protein_id="WP_159506577.1"
                     /transl_table=11
                     /translation="MSEEKRDSADRDGLGGGPWWAGLGPVGGAVLIVAGLALALFFFLF
                     LGRSGSEQHLRVLLGAGKIVAIGLVLVGTALIARRRGTHETDADGNPPGGDDGTG"
     gene            complement(16166..17488)
                     /locus_tag="GR130_RS23775"
                     /old_locus_tag="GR130_23775"
     CDS             complement(16166..17488)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606633.1"
                     /locus_tag="GR130_RS23775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23775"
                     /product="MFS transporter"
                     /protein_id="WP_159506578.1"
                     /transl_table=11
                     /translation="MSSERISPPPRPAVLGIPRALIWGYVGVLLFMIGDGVETSYLPTY
                     FKTDLGFAEASVGVVFTVYGVTAAVGAFLAGGLCDLWGPRRVMTAGAGCWAVCHALMLA
                     VAVPAHSYWLILITYGLRGFGYPLFAYGFMVWIMAGAPERQLGKALGWFWFCFTMGYPV
                     LGSVLVSLLKPAIGFYGTLWVSLAMITAGALVVLLLLRDRAGFQGLSRGPERAGLSRTF
                     MGCLTVMFARPRVGMGALVRLINTTSQFGVWVFLPLFLVDRIGFSTQEWASLLIVMMVS
                     NLACVVLFGALGDRWSRRKTVAWLGGVVSALACLALYYVPETAGHDYPLVAIAVGALGV
                     GMAGYVPLPPLMTAQAPERKGQVMSAYTLGAGASMALGPLIGTVFLGVLGIGGVLGIYA
                     ALHLLSTVLVLRMKTPAPRPESGGPVPAAHPEPEVTTGGVR"
     gene            17652..18443
                     /locus_tag="GR130_RS23780"
                     /old_locus_tag="GR130_23780"
     CDS             17652..18443
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543316.1"
                     /locus_tag="GR130_RS23780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23780"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_159506579.1"
                     /transl_table=11
                     /translation="MRASRGSEAEVEERRRTVLRHVAQEGEIRISELAARMHVSVMTMH
                     RDLDNLHERQLLRKGRGVATAFSNVAMESALRFRENARVEIKSAIADALAAEVSPGDTV
                     LIDCGSTLFPLARRLADVDGIRVITNSLRITYLLAASPAEVTLLGDRYYEDFESCAGPQ
                     TRRQLQDIRATVAFVTATSVREGRLFHPVREYAETKQAYLQAADRAVLAVDHSKFGRTA
                     TYPYGDVSGYDLLVTDTGTPESELRAVRDLGVEVRTVDPLD"
     gene            18491..19489
                     /locus_tag="GR130_RS23785"
                     /old_locus_tag="GR130_23785"
     CDS             18491..19489
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576895.1"
                     /locus_tag="GR130_RS23785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_23785"
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_159506580.1"
                     /sec_met_domain="ADH_N (E-value: 2.6e-32, bitscore: 109.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 9.9e-17, bitscore:
                     60.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVVIHTPGHYEVTTVDDPTPGPGEVVVAPAAVGICGTDVHIVQ
                     GEFAPTPYPIIPGHEFTGEIVALGPGVSGLRTGEQVAVDPSLFCGACHYCAIGRGNLCE
                     NWGAIGDTVDGAMAEYVAVPAANCYRLPSSVDVVQGTLIEPLSCAVRGFDVLPRRLGDH
                     YLIYGAGTMGLMMLQLARAAGAASLSVVDLNTDRLAVAERLGADATAVSAADLDRPQGW
                     ETVIDCTGAIPVIEDGLSRVRRGGTFQQFGVAPSAARASFSPFDVYNNEITIVGSMAVL
                     HSFGRAVDLMAKGVVDADTMITHSFGLDDFGTALQTFRDGSGRKIQLRPQR"
     misc_feature    18519..18534
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
ORIGIN
        1 gcgaccggct cgcggggagg gcgtgtcccg ggggcggcat ccgcggtccg gagggtaagg
       61 cttcacccat gcatgccgta ctgcacgccc tgtcgatcgc cggttccatg gcctgggaaa
      121 tcacctgggc gctgatcctg ggcttcgccc tgtccgccgt ggtccaggca ctcgttcgca
      181 agtccaccgt cgtcgcgctg ctcggcgacg accgcccccg cacgctcgcg atcgccgccg
      241 ggctcggcgt cgcctcgtcc tcctgctcgt acgccgcggt cgcgctcgcc cgctcgctgt
      301 tccgcaaggg cgcgcacttc accgccgcga tggccttcga gatcgcctcc accaacctgg
      361 tcgtcgaact cggcgtcatc ctggccctgc tcatgggatg gcagttcacc gcggcggagt
      421 tcgccggcgg caccatcatg atcgtcgcgc tggcggtgct gttccggctg ctgctgcctt
      481 cggaactgct gcgcgaggcg cgcgcgcagg cggaccgcgg gctggccggc tcgatggagg
      541 gccatgccgc gatggacatg tccgtacggc gccccggctc gttcgcccgg cggctgttct
      601 cccccgaggg gttcaccgcc accgcgcacg tcttcgtcat ggagtgggcg gcgatcctgc
      661 gcgacctggt ggccggcctg gtcgtcgccg gtgcgatcgc cgcctgggtg ccggactcct
      721 tctggcgctc cttcttcttc gccggccatc cgctggcgtc cgcggtgtgg gggccgctga
      781 tcggcccgct ggtcgccatc gcgtcgttcg tctgctccat cggcaacgtg ccgctggcgg
      841 tcgtgctgtg gaagggcggc atcagcttcg gcggcgtcgt ggcgttcgtc ttcgccgacc
      901 tgctgatcct gcccatcctc cacatctacc ggaagtacta cggcggccgg atggcgctct
      961 tcctcctcgg caccttctac gccgccatgg tcaccgccgg ctacgtcgtg gagttcgcct
     1021 tccgcgccct cggcctcgtc cccgaccagg cccgtgccag ggtccccatg gagggcgtct
     1081 cctggaacta caccagctgg ctcaacatcg ccttcctcct cctcgccgcc gcccttctgg
     1141 tgcggttcct ccgcaccggc ggccgggcga tgctgggaat gatgggcggc tcccccgcca
     1201 cggcgaacgg gcacgggaac catggcagtt gacgaccgcg gcctccttcg caccgtgccc
     1261 gaaagggcgt tgccaggaag gctggcggcc ggccgccgcc agcggccccc ggtcggcacg
     1321 ccaccggcgc cccgtgctca ggagagccgc aggtcgatcc agggggtggt gtcaccgggc
     1381 agcagatagc gctccgtctc ggcgaaaccg tgcttcaggg cgaaccgcag accgtcctcg
     1441 ttggaggaca gcacgacggt ctcgaccgcc tcggcgccga gttcgcgcgc ccgccgcaga
     1501 ccgcgcgcat acagttcctc gccgaacccc cggccgcggt gcgcggcgag cacccgtgcg
     1561 atcaccgtgg cggtcgacgg gtcgtccacc ggcgggcgca cggtgctgca ccccacgagg
     1621 acgtccccga cataggccac ctccaggtgg ttcctccggg cgcgttccct gacgtcgtcc
     1681 agggacagca catgggtcgg gatgacggcg ttgtggacgt gccgccagtc cgcgaacccg
     1741 gcgtcgccgt ccggttgtgt gatgcgcagg tcagacatcg cagcaggaaa cccgggcgca
     1801 ccccggggcg tcaactccgt ccgcccgtcg ccggccgcac cgtcgccgcg ccgaggccgg
     1861 tcggcagccg cggtacacct gcccgggttc gcgacgtcgc ggtggcgccc cgtgcgtgcg
     1921 gggcgccaca cgaccggcgg tgggcgggac ggaaggcgcc gggctcaggc gcgacgagga
     1981 gggcatcggg gacacggcgc gccaccccaa cggcccgtgg gcgagggcct tctcaggtgg
     2041 tcggccgctg tgggccgggg gtcgcgcgca ggacgcggtc cgggcggatc ggcaggtgcc
     2101 ggtggcgggt accggtcgcg tgccagaccg cgttggcgat cgccgccgcg gcgcccacga
     2161 tgccgatctc gccgattccc ttgatgccga ccgggtcctc gtcgtccggg tcgtccaccc
     2221 agtccgcctc gacgaccggt acgtcggcgt tcgacgcgaa gtggtacgag gccaggtccg
     2281 ctccgacgtg gccgcccgag acctcgtcgc ggaccgcctc ctcgtgcagg gccatggaga
     2341 gcccccagat catgccgccg atgagctggc tgcgcgcggt cagcgggttg acgatccggc
     2401 cggcggcgaa ggtgccgagc atccgccgta cccgcacctc gccgctggtg acgtccacgg
     2461 ccacctcggc gaactgggcg ccgaaggagt gccgttcccg ggccggcagc gcgccgatga
     2521 gttctgcggt gtccgaccgc gcggtgatcc cctgcggcgg aacgccgccg cccagggcga
     2581 gttggccacg caaggcgcgg gccgcgacgg tgaccgccca ggcccaggaa cgggtgccca
     2641 tcgagccgcc ggcgatcatc gccggtccga agtcgctgtc cgcgatcctc atgcggatgc
     2701 ggtccggtgc cacctccaac tcgtccgcgg cgatcagggt cagcgcggtc cgcgcgccgg
     2761 tcccgatgtc ggcggcggtg atgcgcacgg tgaacgtgcc gtcggcctcc gccgtcacgg
     2821 acgccgtgga cggggcggcc ccggagggga acgaggccgc cgccataccg gtcccgagca
     2881 gccagcgccc ctcgcggcgg atgcccggac gggggtcccg gtccgcccag ccgaaccggc
     2941 gggcgccctc ctcgtagcag gcgagcagat tgcggctgct gaaaggcagc ccggagacgg
     3001 ggcccgcggc gggctcgttg cggatgcgca gggcgatcgg gtccaccccg cacttctcgg
     3061 cgagttcgtc gagcgcggac tccagcgcga acgagcccgg cgcctcgccc ggggcgcgca
     3121 tccaggtcgg ggtcggcaca tcgagccgca ccacgcggtt gacggtgtgg tgcgcgtcgg
     3181 cgtcgtacat cacccgcgcc gggtccgcgc tgcgctcgac gaactcccgc tgggtcgagg
     3241 tgaggttctg cgcctcgtgg tcgagcgccc gcagccgccc gtcggggtcg gcgccgagcc
     3301 ggacccgctg cacggtcggg ctgcggtagc cgaccagcga gaacatctga cgtcgcgtca
     3361 gcacgacgcg gaccggacgg tgcaggacgg tcgccgccat caccgcgagc acctggtgcg
     3421 gacgggtccc cttggacccg aaggcaccgc cgacgtgttc ggagcgcacc cggaccgcgc
     3481 ccgggtcgag ggagaacagc ttcgccagct cctgggccac gaagacgctg ccctggttgg
     3541 agtcgacgac gtcgagccgg ccgtcgtccc agtgcgccgc cgccgcgtgc ggctccagcg
     3601 ggttgtggtg ctcctcgggt gtggtgtact ccgcgtccac cacgaccgcc gacgcggcga
     3661 actcggcgac cgggtccccc ttctgccgct ccgccgccgc acggggagtg tccgccgggg
     3721 tgtacgtacc cgggcgcccg gccgcgaacg cgatgtcgtg cggctcctcg tcgtaccgca
     3781 ccaccagcgc ctccgcggcc tccctggcct gctcggaggt ctcggcgacg accagcgcca
     3841 ccggccagcc ggcgcacggc acccggtcgt gctggaagac caggatcgcc gggtcgggcg
     3901 gccccatggg gccggtgtag tccccgtcga cgcgcggggc gttcccgtgg tggagcacgg
     3961 tgagcacgcc gggcatctcc agcaccggcg cggtctccac ggcacggatc cggccgcggg
     4021 cgatggtgga caacaccagc cagccgtggg cgagttcggc gaacgggatc tcgccggcgt
     4081 agcgggccgc cccggtgacc ttgtcccggc cctccacgcg ggtgtgcgcg gtgccgacgg
     4141 cccccaccag cgcgagccgt ccggtggtcg tggtcgtcat cgggcggcct ccccgctccg
     4201 gtcggttgcc gccccggacg ctcctgatgc cgcgggcggt tgggacagct cggacagtac
     4261 ggcgatgacg aggttgcgca tcagtgtcac cttgtaaccg ttgtggggca gcgcccgggc
     4321 ggctgccagc tcggcgtccg cggcggccgc gaacgcctcg gcgctcgccg gtcccccggt
     4381 cagcagccgc tcggcctgcc gggcccgcca gggccgggac gcgaccgccc cgagggcgag
     4441 ccggacctcg tgcacgacgc cgtcccggac gtcgagggcg gcggcgatcg acccgatggc
     4501 gaaggcgtac gaggcgcgct cacgcacctt gcggtagcgg gagcgggcag cgaccggggc
     4561 cggcgggagg gtgacgccgg tgatgagcgc accggccggc agcgcggtct ccaggtgcgg
     4621 ggtgtccgcc accgggcggt agaactccgc gagcggcaac tcgcccggcc cgtcggccgt
     4681 ttcgtaggcg accgcggcat cgaaggcggc cagcggcacc gccatgtcgg aggggtggac
     4741 ggccacgcag tgcgcggagg ctccgaggat cgcgtggttg cggtgctcgc cctcgacggc
     4801 ggggcaacca ctgccgggga gccgcttgtt gcacggcctg gtcacgtccg tgaagtagcc
     4861 gcagcgggtg cgctggagca ggttgccgcc gaccgtggcc atgttgcgca gctggcccga
     4921 ggcgccggcc agcacggcct gcgccaacgc cgggtagcgg cgccggactt cggggtgggc
     4981 cgcgagatcg ctgttggtga cggtcgcgcc gatccgcagc ccgccggtgt ccgtggcctc
     5041 gatccggtcg agcggcagct cccgtacgtc gacgagcagc gcgggccgct cgaccccggt
     5101 cttcatcagg tcgacgagat tggtgccacc gcccagatag cgcgcctcgg gctcggcgcc
     5161 gagcagcgcg acggcgccct ggacgtcgga tgcccgccga tagccgaact ccctcatgcc
     5221 gcatcctccg cgttctccgc gtccgccggc cgcccggtgt ccgccgcggc ccgcgtgacc
     5281 gcctgcacga tcgccacata cgcgccgcac cggcacaggt tgccgctcat ccgctcccgg
     5341 atctcgtcgg cggtcagcgg tggcaccccg gcttcgggcc gtacgtcggc ggtggccgcg
     5401 ctgggccagc ccgccgcgtg ctcctcgatc accgcgatcg ccgagcagat ctgccccggt
     5461 gtgcagtagc cgcactggta gccgtcgagg tcgaggaacg cctgctgcac cgggtgcagc
     5521 cgcgcgccgt ccgcgacgcc ctcgatggtg gtgatctccc gcccttcggc ggccaccgcg
     5581 agctggaggc aggagaccgc ccggcggccg tcgacgagca ccgtacaggc gccgcactgc
     5641 ccctggtcgc agcccttctt cgtgcccgtc aggccgaggc gctcgcgcag cgcgtcgagc
     5701 agtgtggtgc ggtggtcgac gggcagcgtg tgcttctcgc cgttgatgtt cagggtgatg
     5761 gcgccggccg tcgatagggc catgatcagc ctcctttcgc gtgaaggggg cgcggcgggc
     5821 gccggcgtga tgcccgccgc ggtcgaccag gacgtggtgc gtgccccccg gacgaacgcc
     5881 cccgggcggg gcgatcccag ggccgtgcgg actacgggaa gggagggcgt ggtgcggtgc
     5941 ccagcggcgc cggagcgggc accggccgcc ggatgcgcgg tggcggccgg accgcggggg
     6001 ccccggcact ccaaccggcc gtatccaccg ccccgtctgc cgctatggtg gccttaagcg
     6061 gacacctgtc cactaccccg gaaacctacc ggacagctgt ccgcttatca agactgccca
     6121 tggagaccgc tcgccgagac cgcccaccgg gaagactcat caagaccgga ccggaccgga
     6181 ccggccgcga atccaggaag gaggacgagt gcaacgccct cacggcgcac cgctgcgcgc
     6241 cgacgcacag cgcaaccgcg accgcatcct ggaagtggca ctggccgagc tgacgcgcgc
     6301 ggccgacgcc ccgctgagcg ccatcgccaa gaaggcgggc gtcggccagg ggaccttcta
     6361 ccgcaacttc cccgaccgcg aggcgctcgt cctggaggtc taccgccacg aggtccagca
     6421 ggtctgcgac gccgccgccc acctcctcgc cacccagccg cccgaccggg ccctgcggga
     6481 atggatggac cggctcgccc aatacgccat ggccaaggcg ggtcttgccg ccgccctacg
     6541 caaggccgtc ggcacccacg gcacgctcgt cgggctcgcc cacggcccgc tgacctcggc
     6601 cgtctccctc ctgctggcgg cgaacaagga ggccggcacc ctccgcccgg gagtcacccc
     6661 cgacgatttc ctgctcgcca tctccggcct ctggcagctc gacccgcacg gcgactggca
     6721 gtcacgcgcc ggccgcctcc tggacctcgt catggacggc ctccgcaccg gcgcccccgg
     6781 cgcctgagcg accgtggccc cgcgctcgcg cgacacccca ccgaccggta cgtcaacggg
     6841 tagttggccc aggcagacat cccttccgac gcccccgcag caggcgtaaa atctccccca
     6901 tagtgccatt ctcacgcgta ccggatgaat gcggcaccac gggactcggt tccctctcct
     6961 gcacatcaag cccgcgcgtc aagcgcattc acgcgtcacg gctttcccag gcccccgtgg
     7021 agatcaccat gaacaccgcg ccatcgacac acaccgaaca cgaagacgag ccatggacca
     7081 tctccgtggc ggaccacccc ccgcgcaccg acagcccgca gttcgtggca agccgcaagt
     7141 tgatgaatga acttgtcggc acgatggacg actggccgtt cgcgcccggt ccgtatcagg
     7201 accatcacgg ggccggcatg tggctcaagg acaccaaggg ctggatgtgc atcatcctgc
     7261 cgctcggcat cgagtggtcg gcgcagttct gcgcggaccc agcgaaggtg gaccgcatgc
     7321 ggcaatacgc cctgcgcgtg atcgcggcct tcccggacac cctgcccggc tacgtgagcc
     7381 tcggttacga cgacggcgaa cggctgctca acaccccgat acagaccgcc gaccaggtgg
     7441 ccgagtggac ggattcgata ttcaacgcct cggtgccgct gcccgccggc gcgcacaccg
     7501 gggtcctgcc gacggcggcg ggttaccacc actacccgaa gccgatcgtg gacatcgacc
     7561 acttccgcta cgacgacttc cagctgttcg tgacgggccc caagggcctg ccggtcgcgg
     7621 tggttccggt cgccccgcgc ggctccggcg acggccgggt gcaagtactg gccgcccacc
     7681 cccggtcgcc gtacgcggcg catctcgtcg cccccggccc ggcaggccgt gccgccgggc
     7741 ccgccgacgc cgaagcacga gccgaggcgt ggcggggcgc catcctcccc gccgacgacg
     7801 acgtggcccg gaaggcgttc catgagcagt tgcagcccgc atagcccccg gcccgggggc
     7861 cgccccggct cggaggcgac accatgccca tcgacttcta cggtgtactg gcgggccgcg
     7921 ccgtcgaccg gcgccgcgag ggaagcaccg gcaccccgca ctaccagatc cacctcaccg
     7981 acaacgccgg cacccactac cgcgcggcgg tgaacgtcct gtcccaacag tccccgcccg
     8041 agctgctgta cctggccgat gacgacttcc gccatccgct gacgcagctc cttccggccg
     8101 ccggctccgg ctggacgacg ctgccgtccc ggtcgggcag caccagcctc gactacatcc
     8161 gcggcaacat gttcgtcccg tcctcgatgc gggtgctgcc ggcggacctc cccggcgcga
     8221 acaacgatct cgccgacctg ctggaccact acgtacaacg cgccatcgcg gatcccacca
     8281 tgcaggtcta cgccttcggc cagcgcttcg gccccgaacc ctccgtcccc gacgaggtct
     8341 ttcacttcct gccgggcaac ggtgtgcacg acatgcacat gaaccagggc aacagcgggc
     8401 ggttccgcgt cgacgacggg gtctggcagg acggcggact gctgatccac ctgcctgccg
     8461 aatcacggtg ggtcgccgtc ttcctcgcct tccagtccca gtcctggcac accgacgaca
     8521 ccaccggcca caccattccg accgcggccc cggtgtccgg cgccggtgcg gcaccgctgc
     8581 gcatcgtggc ggccctcgtc aagcccgccg gcccggcacc ggaagccgag tccgtcaccc
     8641 tgctcaacgc ctctcccgca cccgtcgaac tggcgggttg gcagctggcc gaccagcagg
     8701 gccaccggct cccgctgccc gcacagcagg tggcacccgg agccaccgtc gccgtcccgg
     8761 gcggtaacgg gttccaactc gccgacctcg gcggcacgat caccctgctc gaccccgccg
     8821 gaatcaacgt tcacggagtg tcctacaccg aggagcaggg ccggcgcgaa gggtggacga
     8881 tcgccttctg acccctgtgt tcgcggctgc gcttgcgccc ggcgaaagcg gttgacggaa
     8941 caaccaacgg gcgttgtcgc aacggggatc cacgcccgcc ggcgtgtgat ccaggtgcgt
     9001 cggccacggc acggcgggag aatgaaaccg acctccgggc ggcgaagtcc ccggcccgga
     9061 ggcatggacc aaggcgagca agaagacggc catgaccatc aaaggaatcg acgtatcgtc
     9121 gtcccagccg gagggataca agacatccgg cagcgatttc gtgttcatca agatcaccga
     9181 ggggaccagc tacacgaacc ccaagtggac cggccagcgc aggaccgcgc gcaacgccgg
     9241 cctggtgacc ggtttctatc acttcgcccg gccggggccg atgaagcccc aggccgacta
     9301 cttcctctcc cggatcaacc tggccgatgg ggacatcctc attctcgact gggaggaccc
     9361 gggcgtctcc ggtacgtgga aggacagctg gctcaggcag gtacagacgt ccgcccccgg
     9421 ccacaaaacg ctcctctact gcgaccggga cttctgggag aaccgcgaca ccacgtcctt
     9481 cgccggcgac gggttgtgga tcgccgaata caacggcaag ccggggcagc ccgacatccg
     9541 gcacccgtgg ctgttccacc agtacaccga caccccgatg gacaccagca tcggcaactt
     9601 caaggacaag gcggagctgc gcagttggtc ccgccccctc gtccacctcg gccacagcgc
     9661 ctgaacatcc ccacgtatcg acggtcccgg gggctgttca aggtcggtcg ccgtcgcgac
     9721 ccggcggacc gaccggccac catgcgcacc tgctcacccg ccgggccgcg ccgggccttc
     9781 cccggcccga ggggtcggcc tgagcagcgt cgcgacgcgt tcacgcgcga tcaccggccg
     9841 ctcctgtgaa cgccatatga actcaaccag gcgcctgacc tgcgagttac cgcctggttc
     9901 ggtaccatcc agaaccgaca gtcgggtagg ttttcggtgt cgccgccaca ccgggaacac
     9961 ggggttccca gggactagcg gcacgtaggg acatcgtctc ttgacgacag cgaccgagat
    10021 ttttcacgtc cgtccgtaca ccccgcactg ccaagtcatc accgacgaag gtgatcacgc
    10081 cgtcatcggc atctctccgg ggaactccta cttcacccat cagcgagtcc tcagcctcgc
    10141 ctcctggggg gtggagaact tccgtcaggt cgatctcgtc tacacggatc tgcatgtcgc
    10201 cgacatgtac gaggcgctcg gatatccggc cgtcgacgcc cagcgcaagg ccgtgaagaa
    10261 cctgcgcggt gtacgggcca aggtgaccgc cgccgttgcc gcgctcgacc cggacggcac
    10321 caggctccgc gggcgcccca tgtccgcgct gctggacatc cccgcctatc gcgtcatccg
    10381 cgagagcctc gacgatcgac tgtccaccga cccggcgttc cgcggcgtct gtgatcagct
    10441 cgtggtccag ttcctcacca gcagggttct caacgggcag cagcccacgg accgtcagcg
    10501 tcaggtctgc ctcgactaca tctgcgccga ggcgccgctg ttcatcgaca cccccgcgat
    10561 catgggcgtc ccctcctcgc tcaactgcta ccaccaggca ctgccgatgg ccgatctcct
    10621 ctactcacgc gggcatggtc tgcgcgccac acgcaaccag ggccacgccg tgataacccc
    10681 cgccggcacc ctcaccgaag gacgcgacca gtgacgaccg ccccgaccct gatcgacttc
    10741 ccgttctccc cacgcgggga ccgcctcccc ccggagatcg agcggcttcg cgccaccccg
    10801 gtcacgcggg tgcgcaccat cgccggggac gaggcgtggc tggtctcctc ctacgaactg
    10861 tgcaagcagg tactcgaaga cccccgcttc agcctcaagg acacgtccgc ccccggcgtt
    10921 ccccggcagt acgcgctgac catcccgccc gaggtggtca acaacatggg caacatcacc
    10981 ggcgccggtc tgcggaaggc cgtactcaag gcgatcaatc ccaaggccga cggcctgacg
    11041 gagtggatga ccgaccacgc cacccacctc gtcgacggca tcctcgacta cggcccgccg
    11101 gtcgacctgc gcgggcagtt cgccagcccc tacgccgaac acctccactg ccacatcctc
    11161 ggcatccccc gcgacgacgc acggctgttg gcgtccagtc tcgacatcgc gttcatgaac
    11221 tcggcatgcc ccatcgccgg ggcacgcctg aactgggaca gggacatcgc ctatatgacc
    11281 gggcggctca acgaccccgc caccgacggg ctcctggccg aactcgccgc cctccgtcgt
    11341 gaccccggtt atgcgcacct cacggacgcc atgctcgcca ctgtcggcgt caccatgttc
    11401 ggcgccggag tcgtctccac catgggtgcc ttgacgatgg cggtgttcac actccttcag
    11461 caccctgaag tgtgggagca gttgcgcgcg gagcccggca agataccggc ggccgtggac
    11521 gagttgctgc gcgtgaacct gtccatcgcc gacgggctgc cccgcctggc catggaggac
    11581 atgcagctcg gcgacacgga gatcaggaag ggcgaactcg tcctcgtcct ggtcgaggcc
    11641 gccaacaccg acgagaacgt gttccccgac ccgctcacga tcgacatcga ccggcccaac
    11701 gcggcggctc acctctcgtt cggctacggc gggcactact gccccgccgt cccgctcggg
    11761 aagaagcaca tcgagacagc gatcgaggcc ctcatcaccc gcacccccgg cctgcacctg
    11821 gccgtccccg tcgaccaact cgtatggcgc acccgcttca tgaagcgcat ccccgagcgc
    11881 ctgccggtcg cctggtagga gcggaagcgc cggagtgagc cggcgcccgg caccacgcga
    11941 tggccccgac ctgagagagg tcggggccat cgctgtggag cgatgccgcc gcgggccggc
    12001 cccgggctgc cgggtcctgg tcgccggctc cgtagcggcg tcgggcaacg acccgcaccc
    12061 ggatcccgcc cgccccgcgt tcgcgtcgat cgtcggggcg gtcgccgcgt caggagtgcg
    12121 tgacggcggc agcgcgtcgg gcgccgggga gccgcggtgc gacccgctcg cggggctccc
    12181 ggcgcgcccg gccgactccc ccgtcacgat gaccgttttg gtccacttgg acccaatttg
    12241 acgtatcgtc gccgccggtc cgccatgctg ctgcgtcagg ctgtcatctc gtcatgtcat
    12301 ggaggtgctc aggtgattac tggagaccca cagcaggaca tccacccgca ggcggggagc
    12361 ccgcggcggc gcgtactggc cgcggcggca ctggccccgg cactggccgc ggcggcgccg
    12421 gcccccgccc gcgccctggg ccccgcgcgc gtcccggcca gcgcgccgcc cgggacgagc
    12481 cgccacggcc tgatcaagcc ggtgcacacc acccagtcgg actgggcgag cgtggccgca
    12541 cacctgggcg gtctgggcga catgaagcag aagacgatgt accacaccgg attcccacgc
    12601 cgggacctcc gcgtggtctc cgaccgcgtc accgtcaaac cggcactcgc cctgggatcg
    12661 catgtcgcct tcgtccgcta cgaggacggc agttcgctcg tgatgggcga cctggtggtc
    12721 accgagcacg agttgcagcg gttctgcgac accctgcaca agcaccgcct cgcggtgacc
    12781 gccctccaca agcacctcct cgcccagcgg ccctccgtct ggtggctgca cgtccacggg
    12841 cacggccacg acccggcgca cctcgcccgc ggactgcgcg cggcgttcga cggcaccggc
    12901 accccgctcc cgctgccgcc cggtatcgag aaccccgtcg acctggacac cgacggcgtc
    12961 gaagaggcgc tgggggcgaa gggttccgtc gacggcgaga tcttcaagtg catcttcgtc
    13021 cgccgcgagc gcatcaccga cggcgacctg gtgctgccgc cgggactggg atcgaccacc
    13081 gcgctcaact tccagccgct gggcgacggc cgggccgcgg tcagcggcga ctgcgcgatg
    13141 atcgccgagg aggtgcagaa ggtgttggcc gcgctgcggc gggccggcgc cgaactcgtc
    13201 gagctgcaca accacggcct gacggacgaa ccccggctgt tcttcgtcca cttctgggcc
    13261 gtcggcgacg ccgtccggct ggcccgtgcc ctgcgccccg cgatggacgc caccaacgtc
    13321 atcgcggccg gctgaccggc cgcaggagct acgggaccgg cccaccgggc acgcgcgagt
    13381 gcgcccggtg ggccgccgta cggcccgcca ggggcccgcg gtcagcggcg cgtcgcgcac
    13441 acctcggcca cctccatcag gccgtcgggg gcgaccgtgc ccaccgtctg gccggggctc
    13501 accgtcaggc cgtccctgcg gaccagttcg aggaggtacc cggcccgcag gatgtcccac
    13561 gagacgggca gcagccgcag cgcctcggcg aggatgtgct ggatcggtcc cgcttcatcg
    13621 gccggccgag gacggcgagc agcggtagag ctgcgccgtc gtgccgggct cgcgcgggca
    13681 atgggcccgc acccaggggg cgatggcgcg gccctcggtg gtccccgggc cgccgagcag
    13741 gacgtaccgc agccggccgg tggcgacgag gtggcggaac gctgcctcgg tgggggtggg
    13801 cacggtgcca gtgaagccgc ccatggggag caccttggcg cccgcggcga ggatgtaggg
    13861 ggaggcggtc cgccaactgg tcgtcgcgaa aacgtagtcg gcgccgtcct ggtgagcccg
    13921 ggtgtacgcc aggagccggc gctgcttctc gtcgagcgag gccccgtcgg gggacttggc
    13981 ggccttccgg gcgtcggggg ccgggtgccg cggcgcggta tggcgtcgga cggccaccgg
    14041 gccggtcgag cccatgccgg agtggccgta caccgggttc aggaccgtcg acgcccaggc
    14101 ggcggacggc agcagcatgg cggcgaggcc cgcgccgaga cccagcagcg ccatccgccg
    14161 gcgcgtaccc ccggcgtcct tccgggacag cgcgagcagg gccagcgcgc ccgcccccag
    14221 cgtgatcgcg accggcgtca gccacggcag gaacgtcggg aactgcaccg agacgaacgc
    14281 cgaccagccc accgtgcccg ccaccgccgc cggcagcgcc caggcgcgtg cccggccccc
    14341 ccgacgccag gcgcgccaga actgcaccgt accggcgccg aacagcgccg ccagcggcac
    14401 cgccaccacg cccatgtagt acgtgtggcc gccgatcgaa ccggcgctga acaccaggaa
    14461 gtacgtcacc agccacaccc cccacagcac gaatccggcc cgcagcgggt cggtacgcgg
    14521 cctgccgcgc cgccacacca ggccgcacac cgcggccagc gccgccgtcg ggtagagcca
    14581 gccgacctgc gaggccagcg acgggccgaa catcttgacc cacagcgcgg cggtgggccg
    14641 gctgtggccg gagggggtcg ccggagcggt gccggccatg gtggacacgg cgacgctgcc
    14701 ggtcttctcg gcgctgatgt ggatgctgga gaagcggttg aggaagttgt agccgacgac
    14761 ctggctgacc gccgagttgt tggtggtccc gtcgatgtac gggcggtcct tggccggggt
    14821 cacggccacc agcagcaccc acgacgccga caccgccagg cacatcgcgc ccgccaccgt
    14881 caggtgcgcc agccggcggc gcagcgccgt cggggcggat atcaggtaca gcaggccgag
    14941 cgccgggagc accgcccacg cctccagcat cttggcctgg aaactcaggc cgacccacac
    15001 cccggccgcc agcagcgggc ggacccgggc ctcgcgggcc gcgcgcagcg tggcgtccgc
    15061 ggccaggatc accagcaggg tgaacgccgg gtcctcgacc gccgtacgga acagcccggc
    15121 gatcgccggg gtgagcgcga acgcccccgc cgcgaggagc gccgcgtgct cccccgccca
    15181 gcggcgcacc gcgcggtgca ggaacaccac gctcagcagg ccctcgatga cctgcggcag
    15241 ggtcagcgcc cacggatgga agccgaagat ccgcgcggac agcgcctgcg gccagaggaa
    15301 gcccggcagc ttgtcgatcg tgatcgagct tcccgggtcg aacgcgccga acaggaatgc
    15361 cttccagctc tcggccatgc tgcgggcggt ctccgcgtag aacgcgtgga acgcgctgtg
    15421 ctggatgtcc caggtgaaca gcaccgccgc caccacgagg atcaccggca gcccgaacct
    15481 ggcgtacacc ggccggacct cccggtcctg gcgccgcgtc ccggtgcggg cgagcagccc
    15541 gccgcccgtg tgcgctgcgg acgcggtcgc tgtcgaggtg gtgctggcca tggacgaagc
    15601 ctccctggtg gaactcaccg ttcggagtgc cagatagccg gatcgcccgc cgggatgcca
    15661 tgaccgccga ttgttcagcc aacgttcaga tcctcggccg ccgcgccagg gaacccggcg
    15721 cggtcacccc cgtccgctcc ccgatgaggt ggcgcaccgc cggtgagccg gctcaccccg
    15781 tcccgtcgtc cccgcccggc gggttcccgt ccgcatcggt ctcgtgggtg ccgcggcggc
    15841 gcgcgatcag cgccgtgccg acgagtacga gcccgatggc cacgatcttg cccgccccga
    15901 ggagcaccct caggtgctgc tccgagccgg accggccgag gaagaggaag aagaacaggg
    15961 cgagggcgag gccggccacg atgagcacgg cacctcctac cggccccagg cccgcccacc
    16021 aggggccgcc gcccaacccg tcgcgatcgg cgctgtcgcg cttctcttcg gacaccgcaa
    16081 tctccttctc cggcagggcc gttggcgtac cggaacgcgt cgtctcgggg cgccgcggac
    16141 gttccgggca ccggcgtcga acacgctaac gcacgccgcc cgtggtcacc tcgggctccg
    16201 ggtgcgccgc cgggacgggg ccgccggatt ccggccgcgg agcgggcgtc ttcatgcgga
    16261 ggacgagcac ggtgctgagc aggtgcagcg cggcgtagat ccccagcact cccccgatgc
    16321 cgagcacgcc gaggaagacc gtgccgatca gcgggccgag ggccatgctg gcgccggcgc
    16381 ccagggtgta cgcggacatg acctggccct tgcgctccgg tgcctgggcc gtcatgagcg
    16441 ggggcagggg gacgtaaccg gccatgccga cgccgagcgc gccgacggcg atcgcgacca
    16501 gcgggtagtc gtggccggcg gtctcgggga cgtagtacag cgccaggcag gcgagcgccg
    16561 agacgacccc gccgagccag gcgacggtct tgcgccggct ccaccggtcg ccgagcgcgc
    16621 cgaagagcac gacgcaggcg aggttgctga ccatcatcac gatcagcagg gaggcccact
    16681 cctgggtgct gaagccgatc cggtcgacga ggaagagagg gaggaagacc catacgccga
    16741 actgggacgt ggtgttgatg agccggacca gcgcgcccat cccgacgcgc ggccgggcga
    16801 acatcaccgt gaggcagccc atgaaggtcc gcgacaggcc ggcccgctcc ggtcccctgg
    16861 acaggccctg gaacccggcg cggtcgcgca gcaggagcag gaccaccagg gctccggcgg
    16921 tgatcatcgc gagggacacc cacagagtgc cgtagaagcc gatggcgggc ttgaggagcg
    16981 agaccaggac ggagccgagc accgggtagc ccatggtgaa gcagaaccag aaccagccga
    17041 gcgccttacc gagctgccgc tccggggcgc ccgccatgat ccagaccatg aacccgtagg
    17101 cgaacagcgg atagccgaag ccgcgcaggc cgtaggtgat caggatcagc cagtaggaat
    17161 gggccgggac ggcgaccgcg agcatgaggg cgtggcagac cgcccagcag ccggcgccgg
    17221 ccgtcatgac ccggcgcggc ccccacaggt cgcagagccc gcccgccagg aaggcgccca
    17281 ccgcggcggt gacgccgtag acggtgaaga cgacgccgac gctcgcctcc gcgaagccga
    17341 gatcggtctt gaagtacgtg ggcagatagc tggtctccac accgtcgccg atcatgaaga
    17401 gcaggacgcc gacataaccc catatgaggg cccgggggat cccgagtacg gcggggcggg
    17461 gcggcggcga gatgcgctcc gaggacatgg gcagcactgc gggacctcct gacgggccgg
    17521 gccttcgccc gagcgtggcc aacagactga acaagctcac agagaatttc aagagcttca
    17581 cataaagtgt gtgatgttct agggtgaggc cacggcgaag accgccggac gacgaacggg
    17641 gggtgcccac gatgagagcg agtcgcggct ccgaggccga ggtggaggag cgccgccgga
    17701 cggtgctgcg ccatgtcgcg caggagggcg agatccggat ctccgaactc gccgcgcgga
    17761 tgcacgtcag cgtgatgacc atgcaccggg acctggacaa cctccacgag cggcagctgc
    17821 tgcgcaaggg gcgcggggtg gccacggcct tctccaacgt cgccatggag agcgcgctcc
    17881 gcttccggga gaacgcccgt gtcgagatca agtccgccat cgcggacgcc ctcgccgcgg
    17941 aggtctcccc gggcgacacg gtgctgatcg actgcggctc cacgctcttc cccctcgccc
    18001 gccggctcgc cgacgtcgac gggatccgcg tgatcaccaa ctcgctgcgc atcacctacc
    18061 tgctggcggc gtcaccggcc gaggtgacgc tgctgggcga ccgctactac gaggacttcg
    18121 agtcctgcgc cggaccgcag acccggcgcc agttgcagga catccgcgcc accgtcgcct
    18181 tcgtcaccgc cacctcggtc cgcgaggggc ggctgttcca cccggtgcgc gagtacgccg
    18241 agaccaagca ggcgtacctc caggcggccg accgcgccgt actggccgtc gaccacagca
    18301 agttcggccg caccgccacc tatccctacg gcgacgtcag cggctacgac ctgctggtca
    18361 ccgacaccgg gaccccggag agcgaactcc gggccgtccg ggacctcggc gtcgaggtcc
    18421 gcaccgtaga cccgctcgac tgaaccggct ccggccggaa ctcccacacc cccgagaaag
    18481 gccccgcccc atgcgcgctg tcgtcatcca cacccccggg cactacgagg tcaccaccgt
    18541 cgacgacccc acccccggcc ccggggaggt cgtcgtcgca cccgccgcgg tgggcatctg
    18601 cggcaccgat gtgcacatcg tccaggggga gttcgcgccc acgccgtacc cgatcatccc
    18661 cggccacgag ttcaccggcg agatcgtcgc cctggggccc ggggtgagcg gactgcgcac
    18721 cggggaacag gtcgccgtcg acccgtcgct gttctgcggc gcctgccact actgcgcgat
    18781 cggccgcggc aacctgtgcg agaactgggg cgcgatcggc gacaccgtgg acggcgcgat
    18841 ggcggagtac gtcgcggtgc cggccgccaa ctgctaccgg ctgccttcga gcgtcgacgt
    18901 cgtccagggc acgctgatcg agccgctgtc gtgcgcggtc cgcggcttcg acgtgctgcc
    18961 gcgccgcctc ggcgaccact acctcatcta cggcgcgggc accatgggcc tgatgatgct
    19021 tcagctcgcc agggccgccg gcgcggcctc gctctcggtg gtcgacctca acacggaccg
    19081 gctggcggtc gccgaacggc tcggcgcgga cgccaccgcg gtgagcgccg cggatctgga
    19141 ccggccgcag ggctgggaga ccgtgatcga ctgcaccggc gccatccccg tgatcgagga
    19201 cggcttgagc cgggttcgcc gcgggggcac cttccagcag ttcggcgtcg cgccgtccgc
    19261 cgccagggcg tccttctcac cgttcgacgt ctacaacaac gagatcacca tcgtcgggtc
    19321 gatggccgtc ctgcacagct tcggccgcgc cgtggacctc atggcgaagg gggtcgtcga
    19381 cgccgacacg atgatcaccc acagcttcgg actggacgac ttcggcaccg cgctccagac
    19441 cttccgcgac ggttccggac gcaagatcca gctccgtccg cagcgctgaa ctcccgctgc
    19501 ccggcggccc gtcagggcac ctgatccatt atccggtctg ttccatcccc cacggattcc
    19561 ccgtgaatcc cccgcggatt ccacccgccg attcccctcg ttgaattccc tcgctgattt
    19621 ctcccgctga tttctcccgc tgatttctct cgttgcacgg aagcgacatc gccatgccca
    19681 cagttgccgg ggtggactcc tctacccagt cctgcaaggt cgtcgtctgc gacgccgaca
    19741 ccggggaagt cctgcaccgg ggccgcgccg cccaccccga cggcaccgag gtctcccccg
    19801 aggtctggtg gcaggcgctc cgcgcagcgg gcggcggcct tctggagcag gtggacgccg
    19861 tcgccgtcgc ggggcagcag cacggcctgg tggccctgga cgcggccggg cagccggtgc
    19921 gcgatgcgct gctgtggcac gacacccggt ccgcgcaggc cgcggcggac ctggtcgcgg
    19981 acctcggcgg tccggagaag tgggccgagg cggtcggcac cgtgcccgtc gccgccatca
    20041 ccgtcgccaa actgcgctgg ctggccgagc acgaaccgcg ggccgcggac cgcacggacc
    20101 gggtgctgct gccgcacgac tggctgacct ggcggttgtg cggcggtccc ggcacgtttg
    20161 ccgaaccggt caccgaccgg ggcgacgcct ccggcacggg ctactggtca ccggccgacg
    20221 gcgcctaccg ccaggacctg ctcgcgctcg ccttcgacgg ccgcaccccc cgactgcccc
    20281 gcgtcctggg cccgtacgag gcggccggcc gcaccccgca cggtgcgctg gtggcaccgg
    20341 gcaccggcga caacatgggc gcggccctgg gcctgggcat ccggccgggc gacgtggtga
    20401 tctccctcgg gaccagcggc accgccttcg cgctctcgga gcatcccgtg ggtgacccca
    20461 ccggtgccgt cgcggggttc gccgacgcca ccggccggtt cctgccgctg gtgtgcaccc
    20521 tcaacgccgc ccgggtgctc agctccaccg cccggatgct cggcatcgcg ctcgacgacc
    20581 tcggaccgct cgcccgcacc gccgagcccg gggccggcgg gctggtcctg ctcccttacc
    20641 tgggcggtga gcgcaccccc aacctcccgg acgccgcggg cagcctgacg ggcctgcgca
    20701 cggcgaacat gcac
//
