LOCUS       NZ_CP047146            22619 bp    DNA     linear   CON 30-JAN-2024
DEFINITION  Streptomyces sp. GS7 chromosome, complete genome.
ACCESSION   NZ_CP047146
VERSION     NZ_CP047146.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GS7
  ORGANISM  Streptomyces sp. GS7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9067183)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Multiple polyene macrolides produced by antifungal Streptomyces from
            gut of Macrotermes barneyi facilitates the termite-fungus mutualism
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9067183)
  AUTHORS   Li,J., Ni,J. and Li,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-DEC-2019) State Key Laboratory of Microbial
            Technology, Shandong Unversity, 72 Binhai Road, Qingdao, Shandong
            266237, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-NOV-2019
            Assembly Method                   :: SPAdes v. Nov-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/30/2024 05:53:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,019
            CDSs (total)                      :: 7,925
            Genes (coding)                    :: 7,616
            CDSs (with protein)               :: 7,616
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 309
            CDSs (without protein)            :: 309
            Pseudo Genes (ambiguous residues) :: 0 of 309
            Pseudo Genes (frameshifted)       :: 107 of 309
            Pseudo Genes (incomplete)         :: 258 of 309
            Pseudo Genes (internal stop)      :: 29 of 309
            Pseudo Genes (multiple problems)  :: 79 of 309
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:40:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1857389
            Orig. end                         :: 1880008
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047146.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jinfeng Ni.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22619
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22619
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22619
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12619](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12619)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    313..328
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.84"
                     /tool="antismash"
     gene            complement(413..1549)
                     /locus_tag="GR130_RS07875"
                     /old_locus_tag="GR130_07875"
     CDS             complement(413..1549)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543037.1"
                     /locus_tag="GR130_RS07875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07875"
                     /product="histidine kinase"
                     /protein_id="WP_159504042.1"
                     /transl_table=11
                     /translation="MNKVTGRAWPWWAEALMVCVVGAGTVQQAYVGAGGALFSPRVGVA
                     VALALSVLLRRRWPVFAMVSTMVGALLLGLFFPLLVVFFYRVAQGRFVFEGLCVVVAMV
                     GSSLAHPGSSLWMTRKYGPLMVLLLAVIIGLWTGNRRRHVASLAEQVNRLRVERELRAE
                     QARLEERTRIAAEMHDVLAHRLTVIALHTGALKRRAADLPEPVADRIGLLRTASTDALG
                     DLRDVLGVLRGHDTEERQASRVPGLPALSTVIEEARAAGQQIEAVLEGDPDSVPASHRL
                     AIHRLAQEALTNARKHAGGAPAQLEVRYGPPQSTVVIHNPAGAPCEAVTEGSGYGLVGL
                     TERVAALNGRLEYGPTGSGGWQVAATIPLDDERSRGAA"
     misc_feature    complement(1391..1393)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1406..1408)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1681..2433
                     /locus_tag="GR130_RS07880"
                     /old_locus_tag="GR130_07880"
     CDS             1681..2433
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541564.1"
                     /locus_tag="GR130_RS07880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07880"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_268977866.1"
                     /transl_table=11
                     /translation="MNQTPATATTAPVITTPTTTPRHNGPTAFLREAARSMHTTGAVAP
                     SGSPLARRLAAPLPAPNGRSPLRVLEIGAGTGTVTRALAESIGPGDRLDTVEINPHFVQ
                     LLTEALRTDPALAAASEQIRIIPKSICHTPLPENSYDVIVSCLPFMNFTPDLVRSLMGR
                     YMTALVPGGHLTFFGYLGTLSLRTLLARRAEAARYRAVAAVLAEFSARYGDVNGDSVVW
                     RNLPPARVRHLRAPERCVYGTDSDSFGQ"
     misc_feature    2233..2235
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2433..3068
                     /locus_tag="GR130_RS07885"
                     /old_locus_tag="GR130_07885"
     CDS             2433..3068
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541563.1"
                     /locus_tag="GR130_RS07885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07885"
                     /product="VTT domain-containing protein"
                     /protein_id="WP_159504043.1"
                     /transl_table=11
                     /translation="MTMTPGDLLTTVPPPAAYLVITALVVLESVLFLGPFVPTLGLLLV
                     AGGLAYAGTLALPAVIACAAAGAVIGDFQAHWTGHRFGDGLRTGRLSRRVPGPAWDRAY
                     AAIRRRGRPALLVCRFVPLVRTLVPHAAGAARIPYRVLAPFSATAAVAWACTEAGIGYV
                     SAAFRNQLPGAQGVVLTGGAVAAALLLALGVRAAVVRSRSRGLARSNE"
     gene            complement(3522..4871)
                     /locus_tag="GR130_RS07890"
                     /old_locus_tag="GR130_07890"
     CDS             complement(3522..4871)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014717.4"
                     /locus_tag="GR130_RS07890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07890"
                     /product="ABC transporter permease"
                     /protein_id="WP_159504044.1"
                     /transl_table=11
                     /translation="MLSLVLTSVRTRLGQYLGVLLVSAMSAGLLTLLASVLDSVHHADP
                     GHRAERSAQSLLGLVGGTSGFAALLLVSNTLALVAQQRRTEIGALRVIGATTTQIRIQI
                     VSEAAVVAALGGVAGAAGGTLTLGPVLDWLINHHVLPTGPQPDFSPLGFAVGLLSTIVI
                     AIPAALAAVRGPLRTSAVDALREAAVERRTLPVGRAIAATVALLLAWAVWDRYARKSGA
                     HEALNGALALCMMLLIATWLLLPLVVRPVAALSSLPGRLLSRCTGRLAAANSASAGRRV
                     AAMAGPVLLASGLSTMLLCGNAVSRATATAHNALQQENNAVGMRILMTPLIVCAALGIL
                     NTLLLATRQRRGEFAALRLAGSTRAQLLRMLGWESVVVVLSGLLAAGLVIGVFLAGLST
                     RIVPYLAELPAVLPWADMAKVAAGCAGLGVLGVLVPGVLVLRVNAVHAVE"
     misc_feature    complement(3708..3710)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4182..4184)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4878..5660)
                     /locus_tag="GR130_RS07895"
                     /old_locus_tag="GR130_07895"
     CDS             complement(4878..5660)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541561.1"
                     /locus_tag="GR130_RS07895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07895"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_159504045.1"
                     /transl_table=11
                     /translation="MKMTPPPSLDYRPVTDEHMAVRLRSLRKVHGKGAGAVTALHGIDH
                     GFPAGTFTAVMGPSGSGKSTLLHCAAGLEHPTTGSVVLGGRDLGELSQRQLTLLRRDRV
                     GFVFQDFHLIPALSVAANVELPLRLAGRRPDTHRLNDLLARVGLHDRRRHRPGQLSGGQ
                     RQRVALARALITGPEVVFADEPTGALDRASGREVLALLRGAVDDLGATVVMVTHDPQAA
                     AWADEALLLADGRLVDRLAGPEATTAETIAARLAALEV"
     misc_feature    complement(5583..5585)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5781..7085
                     /locus_tag="GR130_RS07900"
                     /old_locus_tag="GR130_07900"
     CDS             5781..7085
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025168.4"
                     /locus_tag="GR130_RS07900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07900"
                     /product="sensor histidine kinase"
                     /protein_id="WP_159504046.1"
                     /transl_table=11
                     /translation="MELQAQERGAAIYALLGQKSKRLGQSALYLAGGFPVALLWLVVWL
                     PTVALGAATALIAIGLPVLAVAALFGIPFGVVERARLRLFTGRRVPTPHAPHAREDGGA
                     LVWAWRRIREPATWWELGYAAVHCAVAVADFALVAGSLLLSASLLTAPLLRGFTRDGEL
                     RVAVFAARTGLQALLLVPCGGVVLVVVFLVLTRYAEIRARIATSLLTKGRSVASPHQDG
                     KIGQLVRSRARILGAFDAERRRIERDLHDGAQQRLTALIMTLGLARLELADSDPAARQL
                     VDKAYQEARTTLNELRDLVHGIYPAALTDRGLPTALTALAEDCAVPTEAEIDLEGMRTR
                     PPEAVEAATYFVACEALTNVVKHSGATEARLSLRRVGPHLVLEVYDNGVGGVDAEAGSG
                     LLGLADRVAAFEGSVHVSSPDGGPTRLHVEIPCAS"
     misc_feature    7056..7058
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7073..7717
                     /locus_tag="GR130_RS07905"
                     /old_locus_tag="GR130_07905"
     CDS             7073..7717
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524229.1"
                     /locus_tag="GR130_RS07905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07905"
                     /product="response regulator transcription factor"
                     /protein_id="WP_159504047.1"
                     /transl_table=11
                     /translation="MRIVIAEDSALLREGLVQILAKFGHDVVAAVDNAPSLLAAVRDHT
                     PDLAVIDIRLPPGFKDEGIQAAVTLRREHHSLAVLMLSQYLEADYAAELLETGDAGAGY
                     LLKDRIGDVLDFLDSVGRVAAGETVIDPEIVRRLLGRRHGRSSIQALTPRETEVLALMA
                     EGRSNAAIAQDLSVTQAAVAKHIGNIFDKLGLHASGTDHRRVLAVLAYLKR"
     misc_feature    7106..7108
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7553..7555
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7707..9563)
                     /locus_tag="GR130_RS07910"
                     /old_locus_tag="GR130_07910"
     CDS             complement(7707..9563)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541560.1"
                     /locus_tag="GR130_RS07910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07910"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_159504048.1"
                     /transl_table=11
                     /translation="MHGRQQERSGRAPGTWRRIAACAAPFRGRLMGFFCLVLIESALIV
                     LPALLTQRIVDEGVLRHDKSRIIELVVLLVALATVTAVVTYFERRLAVGIGEGMTLNLR
                     QRAFSHVQRMSVAFFTKVPTGSLVTRLDSDVLGAQRAFTTTASTLLSNLVAVVSVAVTM
                     VFLSWQITALAAVLVPACLLPARVLNRRLRRLNRNQLTDNAALVSFMTERFSSQGAFLT
                     KLYGRPVTEVQHFERRGRQLHDAGIRLTVTNAMLALTVSWLATMGTATVYLAGGLLAVD
                     GGITVGTLMAMITLMARLYGPITSLSQSRSEVTAAVVSFERIFEVLDLPPDVQDSPTAV
                     ALPPDAASITFENVRFHHQTPSGSSLVTLDKEAPIGGKERDVLRGLDLHVEAGRTLAVV
                     GPSGVGKSTLVNLVCRLYDPVSGTVRIGQHDLRTVSQESIRDAIGVVAQDSHFFHDTLR
                     ANLTYALPDATDEACESACRAAMVWDTVQRLPGGLDTVVGDGGHHLSGGERQRLAIARL
                     LLKNPRIVVLDEATAHLDSESERRVQQALARALHGRTALIVAHRLSTVRGADRIVLLQD
                     GGVAESGTHEELLAANGLYASLYRTQFGDGMAGAGHPIGISA"
     gene            complement(9671..9787)
                     /locus_tag="GR130_RS07915"
                     /old_locus_tag="GR130_07915"
     CDS             complement(9671..9787)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541558.1"
                     /locus_tag="GR130_RS07915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07915"
                     /product="class III lanthipeptide"
                     /protein_id="WP_159504049.1"
                     /transl_table=11
                     /translation="MANILDLQSLELRDEDVTALDSGNSAHCNDTSGISVFC"
     CDS_motif       complement(9725..9787)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MANILDLQSLELRDEDVTALD"
                     /locus_tag="GR130_RS07915_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9671..9724)
                     /prepeptide="core"
                     /locus_tag="GR130_RS07915_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="4.00"
                     /molecular_weight="1608.7"
                     /monoisotopic_mass="1607.7"
                     /core_sequence="SGNSAHCNDTSGISVFC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MANILDLQSLELRDEDVTALD"
                     /leader_location="[9724:9787](-)"
                     /alternative_weights="1626.7"
                     /alternative_weights="1644.7"
                     /alternative_weights="1662.7"
     gene            complement(9824..9940)
                     /locus_tag="GR130_RS07920"
                     /old_locus_tag="GR130_07920"
     CDS             complement(9824..9940)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541558.1"
                     /locus_tag="GR130_RS07920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07920"
                     /product="SapB/AmfS family lantipeptide"
                     /protein_id="WP_159504050.1"
                     /transl_table=11
                     /translation="MANILDLQSLELRDEDIVALGSGNSEHCNDTSGISVVC"
     CDS_motif       complement(9869..9940)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MANILDLQSLELRDEDIVALGSGN"
                     /locus_tag="GR130_RS07920_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9824..9868)
                     /prepeptide="core"
                     /locus_tag="GR130_RS07920_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.00"
                     /molecular_weight="1378.5"
                     /monoisotopic_mass="1377.6"
                     /core_sequence="SEHCNDTSGISVVC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MANILDLQSLELRDEDIVALGSGN"
                     /leader_location="[9868:9940](-)"
                     /alternative_weights="1396.5"
                     /alternative_weights="1414.5"
     gene            complement(10001..12619)
                     /gene="lanKC"
                     /locus_tag="GR130_RS07925"
                     /old_locus_tag="GR130_07925"
     CDS             complement(10001..12619)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="GR130_RS07925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07925"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_159504051.1"
                     /sec_met_domain="micKC (E-value: 8.6e-243, bitscore: 806.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.5e-13, bitscore: 48.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 2.2e-05, bitscore: 23.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6e-15, bitscore: 53.7,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKRYENYCMADPVFFEAPGRSGNGASDTDFEVSGRPVPEGWRQH
                     RGDMWLELHPLGEHMLEQGWKVHASGTFDNAERIIETVWEYCVPRRYGFKFLASRHAFL
                     GQNSKYAPRGASGKLVTIYPRDEAELTDVLTGLAALLEGEPGPYILSDARYESGPLYVR
                     YGGFRKREILLESGDVVPAMQRPDGELVPDIRRPVFEVPVWVTPPDILKKSIEARTVPS
                     KDTFPYQILKPLHFSNGGGIYVAQRLSDGLQVVLKEARPHAGLDMEAADAVTRLLRERD
                     TLAKLDGIQGIPRLYEHFTAWDHHFLAIEYFEAERLSSKEAQTYPLLGADVDEEQKATY
                     AQWAMDVCRQVETLLDEIHDRGVVYGDLHPHNILVLEDGRAVLVDFETSSFDADGFQQA
                     MAAPGFAAPREYRGTRVDIYAMAILRLWLFMPLVPILTLDREKIHDLIDAMRENFPVPA
                     EYIEAIRTGLGTSVPRTKAAQAGIGRPTVQVQGEATDWPRLLDSMAAAIKASATPERED
                     RLFPGDVRQFSQIGETFAFGAAGVLYALRECGYEIPEGADEWLLSAVERSSTNQPGFFD
                     GLHGVAHTLQKIGREKEALHLIEQIDPTLDQLTNPNLFGGLSGIALNLLHFARVKGDST
                     MSDRAVQLAERVAETVASGRFPQAGGTRSGAELGLVRKSKGPAGLMHGWSGPALLMLRM
                     YEHIGDNSWLDAAFTASHLDLDRCRVSSFNTLNVDEGWRLNPYIETGAAGVAIVGSELL
                     RHRKDGRLLDALEAARNTCAAGFFVQPSLWNGRVGQMVALQYITGPTDSETIQVTRRHL
                     ERLSWHQLGLHGDVVFPGFQLMRISMDYATGNAGILLGLKSALSGTASFLPFLRQAHQE
                     S"
     misc_feature    complement(12230..12232)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13130..14392
                     /locus_tag="GR130_RS07930"
                     /old_locus_tag="GR130_07930"
     CDS             13130..14392
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="GR130_RS07930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07930"
                     /product="histidine kinase"
                     /protein_id="WP_159504052.1"
                     /transl_table=11
                     /translation="MKCKTEFDTPRRAQVLALTIVAAFSVGFLGMVLLDIARASVSTAS
                     IIVSEFVVVALGGIQMQVSASALCGRNLHWIPFSLTAQGLLAHLPLLLVGGLWNGVPGF
                     FIGSLLFSMRGRTVWLLAGCVAVFNPLLVYGVTHDARSARDGLVVTSLIGLTLFGAVRL
                     ANQIREVHALRMDLAQLAVTQERLRFARDLHDLVGHTLSSASVKAELAHRLLAQDPRAA
                     RIEVAELINAVRQAHAEIRTVAQGYRRLSLESELVSARSTLQAAGVTPHFSYHGVSLPQ
                     SSGGVLAAVLREAVTNVVRHSAARHCTVRVTRHKGTTRLIVVNDRPHSARAGDPSESSG
                     LRNLSERVALLGGTLLVSRPTTARGEEFRLEARLPTNLPPTDLAAAGGVASTQRCLLPW
                     RTSDPSRVQGNPNGVDAISGT"
     misc_feature    13667..13669
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13688..13690
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14333..14935)
                     /locus_tag="GR130_RS07935"
                     /old_locus_tag="GR130_07935"
     CDS             complement(14333..14935)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004952147.1"
                     /locus_tag="GR130_RS07935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07935"
                     /product="response regulator transcription factor"
                     /protein_id="WP_159504053.1"
                     /transl_table=11
                     /translation="MRVLLAEDMQLLRGALANLLRQEPDIEVVAELERGDEIVPTALHT
                     EPDLALIDIGLPGMDGLTAAAQLHERLPACRCLIVTSLSQPGNIRRALEAHVTGFLLKD
                     TPPDQLIVAMRKVANGERVIDSELAAAALESAPNPLTPREAEVLRHAAEGARPQEIAKR
                     LHLELSTVRNHLSRVVTKSGARNRVDAIRIALHAGWI"
     misc_feature    complement(14921..14923)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15641..15793
                     /locus_tag="GR130_RS07940"
                     /old_locus_tag="GR130_07940"
     CDS             15641..15793
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GR130_RS07940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GR130_07940"
                     /product="hypothetical protein"
                     /protein_id="WP_201304829.1"
                     /transl_table=11
                     /translation="MQTRALHRYLRWRNANARHPDVLAAQRRERARIRSEKGIRWGGRA
                     RAAAA"
     misc_feature    complement(15678..15691)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     gene            complement(15814..16308)
                     /locus_tag="GR130_RS07945"
                     /old_locus_tag="GR130_07945"
     CDS             complement(15814..16308)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383232.1"
                     /locus_tag="GR130_RS07945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07945"
                     /product="GNAT family protein"
                     /protein_id="WP_236572924.1"
                     /transl_table=11
                     /translation="MSGASRMAGVSLTEYLVTDRARWLWQFQLDQMAADPGHARWMVRQ
                     AVVGDKGLVVGHAGFHGPPDEVGMVEIGYSVAPGFRRQGYARSTLIELLRRTAAETAVT
                     TVRATISPNNVASLATISGFGFVEVGEQWDEEDGLELVFEVPARRIPPAWWEGSRQNTE
                     L"
     gene            <16452..16553
                     /locus_tag="GR130_RS07950"
                     /old_locus_tag="GR130_07950"
                     /pseudo=""
     CDS             <16452..16553
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029046.1"
                     /locus_tag="GR130_RS07950"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07950"
                     /product="site-specific DNA-methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VGVELSSHYADVAERRLRAELTQDDFVLAGPEA"
     misc_feature    16793..16806
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.92"
                     /tool="antismash"
     gene            16827..18017
                     /locus_tag="GR130_RS07955"
                     /old_locus_tag="GR130_07955"
     CDS             16827..18017
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999956.1"
                     /locus_tag="GR130_RS07955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07955"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_159509818.1"
                     /sec_met_domain="Pkinase (E-value: 8.5e-36, bitscore:
                     122.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTPERIGRYTVAKELGSGGMGEVYLAYTPGGDPVAVKLIRSDK
                     LDELTRARFEKEALIARTVIGTNRVARFLDADPFADRPWLAMEYVAGRTLLAYVDEDGI
                     LPLPLVASLGALLAEGLSAVHAAELLHRDLKPQNIIMGKDGPMIIDFGLGAFMDAAKES
                     LSHSGMIIGTVRCMPPEQASGHPKVTPAADVYALGTVLLYAAARHYPYDGAVWEAVAMQ
                     VANPAIGPDLSGVPEGLRPLIASMLAHAPEDRPMLGAVARECATLVKSAGMTPADARLA
                     LIARTTAGGTPDAAKDPLSPSFEKLLEDQAKISESAGPDSPLDGPREGAQADEPDEPET
                     GEAEQAAQGEPDAAAVASQSAPAETRRASRSAGGRPPASKRVADELREQYAVDAVL"
     gene            18180..21242
                     /locus_tag="GR130_RS07960"
                     /old_locus_tag="GR130_07960"
     CDS             18180..21242
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0140658 - ATP-dependent chromatin
                     remodeler activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999957.1"
                     /locus_tag="GR130_RS07960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GR130_07960"
                     /product="SNF2-related protein"
                     /protein_id="WP_201304830.1"
                     /transl_table=11
                     /translation="MSGQSEAVPGARGPEEGLSQEAGEQQVLSGGYAPGAQVLIREDLW
                     LVRKCTLTQRDGWMIEVTGVSPFVRGMDAVFYDRLDVVQRLDPRETELVPDDSPNHRRS
                     RLFLEAVMRKTSLPQTEHRLALADNFLMDQQVHQLRPAELALSMKNAQPRILIADVVGL
                     GKTLEIGVLLAELIRRGRGERILVVTPQHVLEQFQRELWTRFGIPLVRLDSTGIQRVQR
                     DIPAGRNPFAYFKRVIISVDTLKSDVYAHHLEHTEWDAVVIDESHNLVNRGTKNNELAR
                     LLARKTDALVLASATPHNGDASSFAELVRMLDEAAIANPSKYEVDDLRHLYIRRTKTSP
                     EVRESLKETQWADRGPSRPIHVPASAKELAVFKELATRWIPSAPDAPSASRHQLVPYRL
                     LKSFLSSHKALLETVKTRIGNIDNPPPEKSSNGKRRTRPEDPAVREAARAAERAALVDL
                     QHLTEQIEDGDSAKLQALVEELRAMGVGPGSETRVVVFSESIPTLRWLAETVPAALGFA
                     HTTSTDQKKPWLGFGGAVLVMHREATTDQEQQDIVEKFGLYDDPVRILFTSDVASEGVN
                     LHQQCHHLVHYDLPWSLICIEQRNGRIDRYGQKHKPEFRALVLTSDIPWRTDENTGEPR
                     PLDDRLVGEKLLRREEQAHRIEGSAEAVTGLYRAKEEENRLTQDLIAGRTVEESIKQSQ
                     QGAAAFLTGILGQVGAVHEHPEVARAEVPKLFASTADYFEVALRQVCRPNPEDMLSLRR
                     DKDGTIAFEPPADLLYRLKALPKSYLNEQQILPSKDEPARMRVTFSKQLAVKRLNAARE
                     TTESQWPNVSYVTDVHPVLDWLTDKVLVEIGRHKAPVLAAAVTTPTYLVQGIYSNALGK
                     PTVVEWMAVFGLPDNPDVEPLTPELLERYGISPDMPGRATPRDLPGLSALVPAAIDAAE
                     RHLAMREAVYRKQIEATLKPHRDRVAEWRQEALFASARPNEAELDRTAKRRLKLVKSLQ
                     TAGEPMLRLLAVLEPTATTSAATAVEGGTQQ"
     misc_feature    21298..21314
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.99"
                     /tool="antismash"
ORIGIN
        1 tggtgatggt gctcgatgag ccgtcgggca gcagaggggt gcagcatggc ctgcccatcg
       61 gcgacgacct cgacggctcg gatgatgtcc gcagggtcgg tgtccttgag caggaagccg
      121 accgcgcctg cggccagtcc gtcgtagacg tactggtcca ggtcgaacgt cgtgagcatc
      181 acgaccttgg gcggctcagg cagcgcgatc agccgcctgg tggcctcgat accgtccatg
      241 tggggcattc gcacgtccat cagcacgacg tccagacgct gcgcggtggc ccgttggacg
      301 gcttcccgac cgtcggatgc ctgtgcggcg acggtgatgt cgggggcgtc ctgaaggatg
      361 tcggcgagcg ccagccgcac caggccgtcg tcgtcgacga tcatcgtccg gatcacgccg
      421 cccccctgct gcgctcgtcg tcgagcggga tggtggcagc cacctgccag cctcccgatc
      481 ccgtaggacc gtactccaga cggccgttga gcgcggcgac ccgctcggtc agcccgacca
      541 ggccgtagcc cgagccctcg gtcacggcct cgcagggggc accggccggg ttgtggatca
      601 ccaccgtgga ctgcggcggg ccgtagcgca cctcaagttg tgcgggtgct ccaccggcgt
      661 gtttacgggc gttggtcagg gcttcttgcg caagtcggtg aatggcgagc cgatgactgg
      721 ccggtacaga gtcggggtcg ccctcaagga ccgcttcgat ctgctgtcca gccgcccgtg
      781 cctcctcgat caccgtcgat agtgccggca gaccggggac ccgtgaggct tgcctctcct
      841 cggtgtcgtg gccgcgcagc acccccagta cgtcgcgcag atcgccgagc gcgtcggtgg
      901 acgcggtgcg cagtaggccg atccggtcgg ccacgggctc ggggaggtca gcggcccgcc
      961 gcttgagggc accggtgtgc agggcgatga ccgtgagccg gtgggcgagc acatcgtgca
     1021 tttcggcggc gatccgggtg cgctcctcca accgggcctg ctcggcgcgg agttctcgtt
     1081 ccacccgcag acggttgacc tgttcggcga gcgaggcgac gtgccggcga cggttgcccg
     1141 tccacagccc gatgatcacc gcgagcagca gcaccatcag cggcccgtat ttacgggtca
     1201 tccacaggct gctccccgga tgcgccagcg aactgccgac catcgcgacc accacgcaca
     1261 gcccctcgaa aacgaaccgg ccctgagcga cacggtagaa gaacacgacc aggagcggga
     1321 agaacagccc cagtagcaac gcgccgacca tggtgctcac catggcgaac accggccaac
     1381 ggcgccgcag taagaccgag agggctaacg ccacggccac cccgacgcgg gggctgaaca
     1441 gcgcgccacc cgcgcctaca tacgcctgtt gcaccgttcc cgcaccgacg acgcagacca
     1501 tcagcgcctc ggcccaccac ggccaggccc ggcccgtcac cttgttcacc agatcagtat
     1561 gggtacgcaa caccactcca gcatcgccta gttgacggtc gctaccccct actttcgtac
     1621 ggggtgaccg cagcggaacg gccgatggaa caccttcggc ccctgcctag cgtcgtgaac
     1681 atgaaccaga caccggctac cgccacgacc gctcccgtga tcaccacccc gaccaccact
     1741 ccacgccaca acggccccac cgcgttcctc cgggaagccg cccgttccat gcacaccacc
     1801 ggcgcggtcg cacccagtgg ttccccactc gcacggcggc tcgccgcgcc gctgcccgcc
     1861 cccaacggcc gcagcccgct gcgcgtcctg gagatcggcg cgggaaccgg cacggtcacc
     1921 cgcgccctgg ccgaaagcat cgggcccggc gaccggctgg acaccgtcga gatcaacccc
     1981 cacttcgtgc aactgctgac cgaggcgctg cggacggacc cggctctggc cgccgcatcc
     2041 gagcagatcc ggatcatccc gaagtcgatc tgccacaccc cgctgcccga gaacagctac
     2101 gacgtgatcg tctcctgcct gcccttcatg aatttcaccc ccgacctggt gcgctccctg
     2161 atgggtcggt acatgaccgc cttggtccct ggcggacatc tgaccttctt cggctatctc
     2221 gggacgctgt ccttacggac cctgctcgcc cggcgcgccg aggccgcccg gtaccgcgcg
     2281 gtggcggccg tactggccga gttctccgcc cgctacggcg acgtgaatgg cgacagcgtc
     2341 gtgtggcgca acctgccgcc cgcacgggtt cggcacctga gggcacccga gcggtgcgta
     2401 tacggcacgg actcggattc tttcggccag tgatgacgat gacgcccggc gacctgctga
     2461 cgacggtgcc accacccgcc gcgtacctcg tgatcacggc gctggtggtg ctggagtcgg
     2521 tgctcttcct cggcccgttc gtgcccactc tcggactgct gctggttgcg ggcggcctgg
     2581 cgtatgcggg cacgctggcg ctgcccgccg tcatcgcctg cgcggcagcc ggcgccgtca
     2641 tcggggactt ccaggcgcac tggaccggcc accgattcgg cgacggcctg cgcaccggcc
     2701 gcttgagccg ccgggtaccg gggccggcct gggaccgggc ttatgccgcg atccgtcgtc
     2761 gcggccgccc agccctgctg gtctgccgct tcgtaccact ggtccgcacc ctggtaccgc
     2821 atgcggcagg cgcagccagg attccctacc gcgtcctggc cccgttcagc gcgacggcgg
     2881 cagtggcctg ggcctgtacc gaggccggca tcggttacgt cagcgctgca tttcggaacc
     2941 aactccccgg cgcacagggc gtcgtgctca cagggggtgc cgtcgcagcc gcactcctac
     3001 tcgcacttgg tgtacgagcc gcggtcgtcc gcagccgttc tcgcggcctg gcgcggagca
     3061 acgaatagca ccatgcaccg ggagcatccg tactcgtcgc caacatccac gggagggtgc
     3121 ccccacggtg agcacgtggc gcaacctgac ggcgcgccgc tgcttgtacg ccggtgcctc
     3181 gatgctgctg accctctgcg atgagtttgt ctgatggggc tggcttcctc agacgagttt
     3241 cgcctcccgt catcaacggc atggaggttg tacgtccctt cgcgtacgcc tccaggaccg
     3301 ctgcgtcccg caccatctgc ccccggggcc gtcggcagga cccatcactg tgccagcacc
     3361 gatggcggat ccaacgtcgg cgccgagtgg gcactcaaga cccaagaggt cgacgctgct
     3421 gtcggctggc atgaacgtcc agccgcaatc cggctcgcgg cgagcgaggg cctggccacc
     3481 tgacctgcag gagcgaagag cgttgccccg cgaagtagcc actattccac tgcatgtacg
     3541 gcgtttacac gaagtaccag cacgccaggg acgagtaccc ccagtacccc caatccggca
     3601 cagcctgcgg ccactttagc catgtctgcc cagggcaaca cggcgggcag ctccgcgagg
     3661 tagggcacga tccgggtcga cagtccggcc aagaaaaccc cgatgactaa cccggctgcc
     3721 agcaatccgc tcagtacgac gacgacagac tcccagccca gcattcgtag cagctgcgct
     3781 cgcgtgctcc cggccaaccg aagcgccgcg aactctccac ggcgctgacg agtggccagc
     3841 aagagggtgt tgaggatgcc cagggctgca cagacgatca agggggtcat gaggatgcgc
     3901 atgccgacgg cgttgttctc ctgctgaagc gcgttatgtg cggtggcggt cgctcgtgat
     3961 acggcgttgc cacacaggag catggtgctg agcccagacg ccagaagcac cggacctgcc
     4021 atggccgcca cccgtcgtcc cgccgacgcg ctgttcgccg ccgcaagacg gcccgtgcaa
     4081 cgagacagca accgtccagg cagggagctg agcgcggcca ccgggcgtac cacaagcgga
     4141 agcagcagcc aggtggcgat gagcagcatc atgcacaggg ctaaagcacc attgagtgct
     4201 tcgtgggcgc cgcttttacg agcgtaacgg tcccagacag cccaggcgag gagcagagca
     4261 accgttgccg cgatggcgcg gccgacgggc agcgtgcggc gttcgaccgc ggcttcccgg
     4321 agggcgtcga ccgcggacgt acgcaaggga cctcgtaccg ctgccaacgc tgccgggatg
     4381 gcgatcacga tggtggagag cagcccgacg gcgaagccga ggggcgagaa gtcgggttgg
     4441 gggccggtcg gcagaacgtg gtggttgatg agccagtcca gcacagggcc gagggtgagt
     4501 gtcccgccgg cggcgcctgc cacgccgccc agtgccgcga ccactgcggc ctcgctcacg
     4561 atctggatcc ggatctgcgt cgtggtcgct ccgatgaccc gcagagctcc gatctccgta
     4621 cgccgctgct gagccaccag agcgagagtg ttggacacca atagcagggc ggcgaagccg
     4681 gaggtgccac cgaccaggcc gagcagggat tgcgccgacc gctcggcgcg gtgccccgga
     4741 tcggcgtggt ggacactgtc caggacggag gccagcaggg tcagtagacc cgcgctcatg
     4801 gcggagacga ggaggacgcc caggtactgc cccaggcggg tacggacgga ggtaaggacg
     4861 agtgagagca cggccgttca cacctccagg gcggccaagc gggccgcaat cgtctcggcc
     4921 gtggtggcct cgggccccgc cagccggtcg accagccgtc cgtcggcgag cagcagcgcc
     4981 tcatcggccc aggctgctgc ctgtgggtcg tgggtcacca tgacgacggt agcccccagg
     5041 tcgtcgacgg ccccgcggag caaggcaagc acctcacggc cggaggcccg gtccagcgca
     5101 ccggtaggct cgtccgcgaa gaccacctcg ggcccggtga tcagagcgcg ggcaagagcg
     5161 acgcgttgcc gttggcctcc cgagagctga ccgggccggt gccggcggcg gtcatgcaaa
     5221 cccacgcgcg ccaagagatc gttcaagcgg tgcgtatcgg gtcggcggcc ggccaagcgc
     5281 agcggcaact ccacgttggc ggcgacgctc agcgcgggaa tgaggtggaa gtcctggaag
     5341 acaaagccga cgcggtctcg gcgcagcagc gtcaactgcc gctgggaaag ctcgcccaga
     5401 tcacggccgc caaggacgac ggagcccgtg gtggggtgct ccagcccggc cgcgcaatgc
     5461 agcaacgtcg acttacccga gcccgatggc cccatcacgg cggtgaaggt gcctgcagga
     5521 aagccgtgat cgataccgtg cagggcggtt actgcacctg cccctttacc gtgcaccttg
     5581 cgtaaggagc gcaggcggac ggccatatgc tcatccgtaa cgggccggta gtcgagggag
     5641 ggcggtggcg tcatcttcat ggtcctattc aattcccgat ggagatcgtc gtcagtggag
     5701 cgtggtggaa taccggggta gtgctgggtc tacccgtgct tcacggcccg gggcgggcat
     5761 gcggcgccgg agggggagca gtggagctgc aggcgcagga gcgtggcgcg gcgatatacg
     5821 cgttgctggg ccagaagtca aagcggctgg gccagtcggc actgtatctg gctggtggct
     5881 ttccagtggc tctgctctgg ctggtggtct ggctccccac ggtggcactc ggcgcagcga
     5941 ctgccctgat tgccatcggg ctccctgtgc ttgccgttgc ggcgctcttt ggtatcccgt
     6001 ttggagtggt ggaacgggcc cgacttcgtc tgttcacggg ccgaagggtg cccacgcccc
     6061 acgcaccgca tgcacgagag gacggtgggg cgctggtgtg ggcatggcgg cggatcaggg
     6121 agcctgcgac gtggtgggaa ctcggctacg cggcggtcca ctgtgcggtt gccgtcgccg
     6181 acttcgccct agttgcgggc agtctgctgc tgtccgccag tcttctcaca gctccgctgc
     6241 tacgcggctt cacgcgcgat ggcgagctgc gggtcgccgt attcgcggcg cgtacgggcc
     6301 ttcaggcgct gcttctggtg ccgtgcggag gcgtggtgct ggttgtcgtc ttcctggtgc
     6361 tcaccaggta tgcggagatt cgggcccgta tcgctacgag cttgctgacc aaggggcgca
     6421 gcgtcgcgtc accacatcag gacggaaaga tcggccagtt ggtgcgctct agggctcgca
     6481 ttctgggggc gttcgatgcg gagcgtcgcc ggatcgagcg agacctacat gacggggcac
     6541 agcaacgact caccgcactc atcatgactc tgggcctggc gcgcctggag cttgccgaca
     6601 gcgatcccgc ggccagacaa ctggtcgaca aggcatacca agaggcccgc accaccctca
     6661 acgagctgcg ggacctggtc cacggtatct accctgcggc actcaccgac cgcggactgc
     6721 cgaccgctct caccgccctg gctgaggact gtgccgtacc gacggaagcg gagatcgatc
     6781 tggaaggcat gcggacacgc ccgccggaag cggtagaagc ggcaacgtac ttcgtggcct
     6841 gcgaagcgct gaccaatgtc gtcaagcaca gcggcgcgac cgaggcacgg ctgtctctgc
     6901 gccgcgtggg gcctcatttg gtcttggagg tatatgacaa cggcgttggc ggtgtcgatg
     6961 ccgaggccgg cagcggcctg ctgggcctgg ccgaccgtgt ggccgccttc gaaggatccg
     7021 ttcatgtgtc gagtccggac ggcgggccga cccgcttaca cgtggagatt ccatgcgcat
     7081 cgtgatcgcg gaggattccg ccctattacg cgaaggtcta gtacagatcc tggcgaaatt
     7141 cggccacgat gtggtggcgg cagtggacaa cgcgccctcg ctcctggcag cggtgcgcga
     7201 ccacacaccc gatctggcag tgatcgacat tcgtctgccg ccagggttca aagacgaggg
     7261 gatacaggct gcggtgacgt tgcggcggga gcaccatagc ctcgccgtgc tcatgctgtc
     7321 gcagtacttg gaggccgatt acgccgccga actgctagag acgggtgatg cgggtgctgg
     7381 ctatctcctc aaagaccgca tcggcgacgt tctcgacttc ctcgattcag taggacgggt
     7441 agccgccggg gagaccgtca tcgacccaga gatcgtccgt cggctgctgg ggcggcgcca
     7501 tggtcggtcc tccatacagg cgctcacccc ccgcgaaacg gaggtgctcg cgttaatggc
     7561 cgaagggcgt tccaacgctg cgatcgctca agacctgtca gtcacccagg ccgcggtcgc
     7621 gaagcatatc gggaacatct tcgacaagct ggggctgcat gcgagcggca cggatcaccg
     7681 ccgggtgctg gcagtgctgg cctatctcaa gcgctgatgc caattgggtg gccagctccc
     7741 gccatgccgt caccgaactg cgtgcggtag agcgaagcat agagcccgtt tgctgccagc
     7801 agttcctcgt gggtcccact ctccgccaca ccgccgtcct gcagcaaaac aatccggtcg
     7861 gctccacgca cggtggacag gcggtgcgca acaatcaggg ctgtgcgacc gtgcagggct
     7921 cgcgccagcg cctgctggac ccttcgttcc gactccgagt cgagatgcgc ggtcgcctcg
     7981 tcgagcacca cgatcctcgg gttcttcaac aacaggcggg cgatcgccaa tcgttgtcgc
     8041 tcaccccccg agaggtgatg gccgccgtca ccgaccacgg tgtccaagcc accgggcaag
     8101 cgctgcacgg tgtcccagac catggccgcc cggcaggcgc tttcacatgc ttcatcggtg
     8161 gcgtcgggaa gcgcgtaggt gaggttggcc cgcagcgtgt cgtggaagaa gtgactgtcc
     8221 tgggccacca ctccaatcgc atcccgtatt gactcctgag agacggtgcg caggtcgtgc
     8281 tggccgatcc gaacagtgcc actcaccggg tcgtacagcc ggcacacgag attgaccaga
     8341 gtcgacttgc ctacccccga cgggccgacc acggcgaggg tccggccggc ctcgacatgc
     8401 agatcgaggc cccgaagaac gtcccgctcc ttgcctccga tcggggcctc cttgtccagc
     8461 gtgacgaggc tggaacctga tggcgtttgg tggtggaagc ggacgttctc gaaggtgatg
     8521 gacgccgcat ctgggggcaa tgccacggcc gtggggctgt cctggacgtc gggaggaagg
     8581 tccagaacct caaatatgcg ctcgaagctg acgaccgcag cggtgacctc ggagcgggac
     8641 tgcgagagag aggtgatggg tccgtagagg cgagccatca gggtaatcat ggccatgagt
     8701 gtgcccacgg tgatgccgcc gtcgacagcc aagagccccc ctgccagata gaccgtggcg
     8761 gtgcccatgg tcgccagcca ggagacggtg agcgccagca tggcattggt aaccgtcagc
     8821 cgtatgccgg catcatgcag ctgcctgcca cggcgctcga agtgctggac ctcagtcaca
     8881 ggccggccgt agagcttggt gagaaacgcc ccctggctgc tgaaccgttc agtcatgaag
     8941 ctcacgagtg cggcgttatc cgtcaattgg ttccggttca ggcggcgcag ccgtcggttg
     9001 agaacccgag ccggcagtag gcatgcgggc accaatacgg cagccagggc ggtgatctgc
     9061 caggacagga agaccatggt gaccgccacc gaaacgactg ctacaaggtt cgacagcaga
     9121 gtggacgcgg tggtggtaaa tgctctttgg gcccccagga catcggagtc cagacgagtg
     9181 acaaggcttc cggttggcac cttggtgaag aaggcgacag acatgcgttg cacgtgggaa
     9241 aaggcgcgct gccgcaggtt gagggtcatc ccctctccaa tgccaacggc cagacgccgc
     9301 tcgaaataag tcaccacggc ggtgacagtt gccaacgcca cgagcagtac taccagctcg
     9361 ataatccggc tcttgtcgtg ccgcaacacc ccctcatcta cgatgcgttg ggtgagcagt
     9421 gccggcagaa ctatcagtgc cgactcaatc agcacgaggc agaagaaacc catgaggcgg
     9481 ccgcgaaagg gcgcggcgca tgctgcgatc cggcgccacg tgcctggagc ccgaccactt
     9541 cgctcctgtt gcctgccgtg catcgcctct cccttcaggt accgcggtga cctaggccga
     9601 ccgccgcggt cggaaacgac gtgcggggcg gcttacgccg ccccgcactc atccgatctc
     9661 agtcagtcac tcagcagaag acgctgatgc cgctggtgtc gttgcagtgc gcgctgttgc
     9721 cagagtccag agcggtgacg tcctcgtcac gaagctccag ggactgcagg tcaagaatgt
     9781 tcgccatgat gacgctcctt tgaatcagta gggtttgcgg ggatcagcag acgacgctga
     9841 tgccgctggt gtcgttgcag tgctcgctgt tgccggagcc cagggcgacg atgtcctcgt
     9901 cacgaagctc cagggactgc aggtcaagaa tgttcgccat gatgacgctc cttgattggt
     9961 gcggggccaa gacggcccca tggtgggtgt gaacccgccg tcaggactcc tgatgggcct
    10021 gacggaggaa tgggaggaaa ctcgcggtac cgctcaaagc gctcttgagg ccgagcagga
    10081 tgcccgcgtt tccagtcgcg tagtccatcg aaatccgcat cagctggaag ccggggaaga
    10141 cgacgtctcc gtgaagtccg agctgatgcc aggacagtcg ctcaagatgg cgtcgggtga
    10201 cctggatcgt ctcggagtca gtggggcctg tgatgtattg cagggccacc atttggccga
    10261 cacggccgtt ccagagggaa ggctgtacga agaatccggc ggcacaggtg ttgcgtgccg
    10321 cttcgagagc gtccaacagc cgaccgtcct tgcgatgacg caacagctcc gagccaacga
    10381 tggcgactcc tgcggcgccg gtctcgatat acggattgag ccgccatccc tcgtccacgt
    10441 tcaaggtgtt gaagctcgaa acccggcagc ggtccaggtc aaggtgggac gccgtgaatg
    10501 ccgcgtccag ccatgagttg tcgccgatgt gctcgtacat ccgcaacatc agtagggcgg
    10561 gtcctgacca gccgtgcatg aggccagccg gccccttcga cttgcggacc aggccgagtt
    10621 ccgctccgga gcgtgtgcca ccggcctgcg gaaacctacc gctggcgacc gtttccgcta
    10681 ccctctcggc cagttgcacg gcgcggtcac tcattgtgct gtcgccctta accctggcga
    10741 agtgcagcag attcagcgcg ataccggaga gcccgccgaa cagattcggg ttggtcaact
    10801 ggtcgagtgt ggggtcgatc tgctcgatca ggtgcagagc ctccttctcg cggccaatct
    10861 tctggagcgt gtgagccact ccgtgcaggc cgtcgaagaa tcccggttgg ttggtgctgc
    10921 tgcgctcgac tgcggacaac aaccattcat ccgccccctc ggggatctca tatccgcatt
    10981 ctcgaagcgc gtacagcacg cctgccgcgc cgaacgcgaa ggtctctcct atttgtgaga
    11041 attgtcgtac gtcgccgggg aagagtcggt cttcccgttc aggcgtcgca ctggccttga
    11101 tcgccgctgc catggagtcc agtagtcgtg gccagtcggt ggcctcgccc tggacctgca
    11161 ccgtaggccg gccgatgccc gcttgtgctg ccttcgtcct gggcacggac gttcccaacc
    11221 cggtgcggat ggcctcgatg tactccgccg gtacggggaa gttctcccgc attgcgtcga
    11281 tcaggtcgtg gattttctcc cggtccagcg tgagaatcgg aacaagaggc atgaagagcc
    11341 aaaggcgcag gatcgccatc gcgtagatat cgacccttgt gccgcggtat tcccgaggcg
    11401 cagcaaagcc cggtgcggcc atggcctgtt ggaagccgtc agcatcaaag gaggacgtct
    11461 cgaagtcgac gagcactgcc cgaccatcct caagcaccag aatattgtgt gggtgcaggt
    11521 cgccgtacac cacaccccgg tcgtggatct catcgaggag tgtctccacc tgccggcata
    11581 catccatggc ccactgggcg taggtcgcct tctgctcctc gtccacgtca gcgccgagca
    11641 gcggatatgt ctgggcttcc tttgaactca gccgttcggc ttcgaagtac tcgatggcca
    11701 ggaagtggtg atcccaagca gtaaagtgct catagagccg cggtatcccc tgaatcccat
    11761 cgagcttggc caacgtatcc cgctcacgaa ggagccgggt taccgcgtcg gctgcctcca
    11821 tgtcgagtcc cgcgtgtggt cgggcttcct tcagaactac ctggagccca tcggagaggc
    11881 gctgagccac atagattcca ccgccgttgg agaagtggag cggtttgagg atctggtacg
    11941 gaaaagtatc cttcgaaggt actgtgcgtg cctcgatgct cttcttcagg atgtctggcg
    12001 gcgttaccca aaccggcacc tcgaagaccg gtctgcgtat gtccggtacg agctcgccgt
    12061 ccggccgctg catggcgggg acgacatcac cgctctccag caggatctcc cgcttgcgga
    12121 accctccgta acgcacgtag agcggtccgg attcatagcg cgcatcgctg aggatatacg
    12181 ggccgggctc gccctccagg agggctgcga gaccagtcag tacatcggtt aactccgcct
    12241 cgtcacgggg gtagatcgtg acgagcttgc cgctcgcacc tcgcggagca tacttactgt
    12301 tctgccctag gaaggcgtgc cggctggcta ggaacttgaa gccgtagcgg cgggggacgc
    12361 agtattccca caccgtttca atgatgcgtt cggcgttgtc gaaggtgccc gaggcgtgca
    12421 ccttccaccc ctgttccagc atgtgctcac caagggggtg gagctccagc cacatgtccc
    12481 ctctgtgctg ccgccatcct tcgggaactg ggcggccgga cacctcgaaa tcggtatcgc
    12541 ttgcgccgtt gccagaccgg ccgggggctt cgaagaagac tgggtcggcc atgcagtaat
    12601 tctcatagcg cttgtccaca gaaattcccc tccgctgtct gcaagttccc cgggcgtgat
    12661 ggcccggtgg agcccagtcg gcgccccgcg ttcttgctgg acgcaccatg aatcttgccc
    12721 ggtggatcgc tgcgggacga gagaggaact cccgaaatcc cctgttaata cttcacggtc
    12781 ggacgcggga acggctcagg cgtcggtgtc gtccggcgct gggggtggcg agcatcgaaa
    12841 atgcggaatc taggggtccg gcactagcgg cttcaagttg ctggtgcaag cgacgagctc
    12901 aaccccggct caggttggct aaaaataaag ggtaatggtt cagaggtgtg attccttata
    12961 attgccgccg gtcttcgcga gggcgcgaac gtcttcacag cggcgttggc tgccttgctg
    13021 agcaatcgcc aacctcagga gacagtcggc gtgccctccc gaagccgaca gctgcacgaa
    13081 cagtggaaat gcgctcatgt cgggagggga tgaagagggg gacacgcgag tgaagtgcaa
    13141 aactgagttc gacacgccaa gacgagcgca ggtactggcg ctgactatcg ttgcggcctt
    13201 ttctgtgggg ttccttggaa tggttctctt ggatatcgcc agagcctccg tgagtaccgc
    13261 atccatcatt gtcagtgaat tcgtggtcgt cgcgctcggc ggaatacaga tgcaagtcag
    13321 tgcctctgcc ctgtgcggtc gtaatctaca ctggatcccc tttagcctga cggcgcaggg
    13381 tctgctggcg catctccccc ttctccttgt cggaggtctg tggaacggcg taccgggctt
    13441 tttcatcggc tccctgcttt tcagcatgcg cggccggacg gtttggcttc tggccggctg
    13501 tgtggccgtc ttcaacccac tactggtgta cggcgtcacc cacgacgcac gttctgcccg
    13561 ggacgggctg gtggtcactt cgttgattgg attgacactg tttggcgcgg tgcgtttggc
    13621 caatcagatc cgtgaggtgc acgccttgcg tatggatctg gctcagttag ccgtcaccca
    13681 ggagcggtta cggttcgcac gcgacctcca cgatctggtg ggccatacgc tttccagcgc
    13741 ctccgtcaag gccgagctgg cccaccggct gctcgcgcag gacccacggg ccgcccgtat
    13801 tgaggtcgcc gagctcatta atgccgtccg acaggcacac gctgaaatac gtacggtcgc
    13861 ccagggatac cgccgtctct ccttggagtc ggaactggtc tcggcccgat caacgctcca
    13921 ggctgcaggc gtaacgcccc acttttcgta tcacggtgtc tcactgccgc agagctccgg
    13981 tggcgttctg gcagcagttc tcagggaggc cgtgaccaac gtcgtgcgtc atagtgcggc
    14041 tcgtcactgc acagtacggg tcactcggca caagggcact acccggctca tcgtcgtcaa
    14101 cgaccgcccg cactccgcgc gggccgggga tccctccgaa tcaagcgggc tgcggaacct
    14161 ctccgagcgt gtcgccctcc taggggggac cctacttgtc tcacgcccaa caactgcccg
    14221 gggagaagag ttccggctgg aggcccgcct accaactaac ctcccgccta cggacctagc
    14281 cgctgctggt ggcgttgctt cgacccaacg gtgcctgctc ccctggagga catcagatcc
    14341 atcccgcgtg cagggcaatc cgaatggcgt cgacgcgatt tctggcacct gacttggtga
    14401 cgacccgcga cagatggttc cgcacggtgc tcagctccag gtggagccgt ttcgcaattt
    14461 cttggggtcg cgcaccttca gccgcatgtc gtagcacctc ggcctcccgc ggggtgaggg
    14521 ggttcggagc actctccaac gctgctgccg ccaactccga atcgatgacc cgttcaccat
    14581 tcgcgacctt ccgcatcgcc acaatgagtt ggtccggggg cgtgtccttc aacaggaacc
    14641 ccgttacgtg cgcctccagg gcacgtcgga tgttcccggg ctggctcagg ctcgtgacga
    14701 tgagacatcg gcatgccggg aggcgttcgt gcaactgggc agcagcagtg agtccgtcca
    14761 tgcccggtag gccgatgtct atcaatgcga gatcgggttc ggtatgcagt gctgtcggca
    14821 caatctcgtc cccacgctcc aactcagcaa cgacctcgat atccggttcc tgccgcagca
    14881 ggttggccag cgcgcctcgc aggagctgca tgtcttcggc taagagcacc cgcattgcgt
    14941 atctctcctt ccagcccgcc ccgttggcga tcagcggctg ataaagctcg aaacttcctc
    15001 acgtctcgaa ccttctcatc ccttgccgct ggtgtcagag aacgccacgc ggtgctgtcc
    15061 accacctcga gccgcatggc gatatacggt caagttcatg tccgtatagg cgagttggtg
    15121 gctcatgcgg gtttccggcg gtggtgacgg tcaggtgcgg caggagatga gatcgcagca
    15181 ggtgccacag tcggggcggg cttgatgagg tgaggattgc tggggaagcg ggcctggggt
    15241 gggggagccc gggaagacgt gacggcgggg tagttcgcgc tggtcgccgg cggcgctacg
    15301 ccggcgttgg cggacgtcgt ccagtggccc aagggcgtgg agggcgtagc cgatcagccg
    15361 ccccggcgcc agggattcgt cgtcggctag cgcacgtagc cgggccgcgt cggctgccgt
    15421 ctgtatgagc gaggcttgga cgacctgctc gccgacgtat tccgcgggcc cggcgaacgc
    15481 cgaggggcgc agatccgcag cacgcgttcg ctagtgccgt gccgggaagg tttgccgggt
    15541 tggtgctcgc gccgggtacc actcggccgg ttggatgtga cgacacatcc gctcgggcgc
    15601 gtggaggcgc ggtggcagag ccggtcaagg tccgcagacc gtgcagactc gagccctgca
    15661 ccgctacctg cggtggcgca acgccaatgc ccgccacccc gacgtcctgg ccgctcaacg
    15721 ccgcgaacgc gcccgcatcc gcagcgagaa aggcatccgc tggggcggac gcgcacgtgc
    15781 tgccgcggcc tgaccgccgc gccgactcca cagtcacaac tcagtgttct gccgtgaacc
    15841 ttcccaccaa gcgggtggaa tccggcgggc agggacctca aagacgagtt cgagaccgtc
    15901 ctcttcgtcc cactgctctc caacctcaac gaagccgaag cccgagatcg tggccaggga
    15961 tgccacgttg ttggggctga tcgtcgcccg gacggtcgtg actgcggttt cggctgctgt
    16021 ccggcgaagc aactcgatca gtgtggatcg ggcgtatccc tggcgacgga agccgggagc
    16081 gacggagtag ccgatctcga ccatgccgac ctcatctggc ggtccgtgga acccggcatg
    16141 cccgacgacg agacccttgt cgccgacgac cgcttgccgc accatccacc gcgcatggcc
    16201 gggatcggcg gccatctggt cgagctggaa ctgccacaac caccgtgctc tgtcggtcac
    16261 caagtactcg gtcagcgaaa ccccggccat cctgctggct ccggacatgc ctccatcgag
    16321 caaagcggac atcgtcccgc cggacagctc gacaaaacgg atgcgttcgg gctcctcgtg
    16381 agcggtctct ggtgatcggc ttcatctgtc acctgcggat gctcgccgac tcacccgaag
    16441 ggtgtccaac ggtcggcgtc gaactctcca gccactatgc cgacgtggcc gagcgcaggc
    16501 tccgagcgga gctgacccag gacgacttcg tcctggcagg accggaggca tgagcgtgag
    16561 agcgatcagg ccagggccga cggactgcag acgcccgggc ggctggtgca tcgagaaacc
    16621 gatgctccag ccgctttcct cttgcggcag gctgctcgaa cgcccgccgt atcagcgatc
    16681 ccgcctaacc agtgcctcga actcgtgatg caccgattcc agccacgaca ggccatgaac
    16741 cagaccgtga gcgactacgc ttgacaggcg ccccggaccc tgagctggtg ggcgtatggg
    16801 catgcgtgag gagtgctgaa cagaagatga cggggacgcc cgagcggatc ggccgataca
    16861 ccgtggccaa ggagctgggc tcgggcggta tgggggaggt gtacctcgcc tacacccctg
    16921 gcggcgaccc ggtggcggtg aaactgatcc gcagcgacaa gctcgatgag ctcacgcggg
    16981 cgcggttcga gaaggaagcg ctgatagcgc gcaccgtgat tggcaccaac agggtggcgc
    17041 gcttcctcga tgctgacccc ttcgccgaca ggccgtggct ggccatggag tacgtagcgg
    17101 gacgcacgct gctggcctac gtggacgagg acggcatcct gcccctgccg ttggtcgcta
    17161 gcctcggcgc gctgctcgcc gaagggctga gcgcggtaca cgccgcagag ctgctgcacc
    17221 gggatctcaa gccgcagaac atcatcatgg gcaaggacgg acccatgatc atcgatttcg
    17281 ggctcggcgc gttcatggac gctgcgaagg agtccctgtc acacagcggc atgatcatcg
    17341 gaacggtgcg gtgcatgccc cctgagcagg cgagcgggca cccgaaggtg acgcccgccg
    17401 cggacgtgta cgcgctgggc accgtccttc tgtacgcggc ggctcgccat tacccgtacg
    17461 acggcgcagt gtgggaggcg gtcgccatgc aggtggccaa ccccgccatc ggcccggacc
    17521 tgagcggcgt gccggagggg ctccggccgc tgatcgcgtc gatgctcgcc catgcccctg
    17581 aggaccggcc gatgctcggt gctgtcgcac gcgagtgcgc aacgctggtg aagtccgccg
    17641 gaatgacgcc ggccgacgcg cggctcgcgc tgatcgcgag gacaaccgcc ggtggtaccc
    17701 cggatgcggc gaaggatccg ctgtcgccgt cgttcgagaa gcttcttgaa gatcaggcca
    17761 agatctcgga gagtgcaggc ccggactctc cgctcgacgg cccgcgggaa ggtgctcagg
    17821 ccgacgagcc tgacgagccg gagacggggg aagcagagca ggcggctcag ggcgaaccgg
    17881 atgccgccgc tgtggcgagt cagagcgcgc ccgcggaaac gaggcgcgcg tcccggtccg
    17941 ccggcggtcg gccgccggcg tcgaagcggg tggcggacga gctgcgggag cagtacgcgg
    18001 tcgatgccgt gctgtgacgg tcacgctgtc ggtgcctggt gagaagcttg ggggacgtgt
    18061 gctcggtggc gggacggaca ccgcccgtag gccagatgga gcgggtgcgg gacgagcggc
    18121 gtcgtgggcg ctgtgagcgt gaggaatggg agcaaacgtt gggtgtcgag gctggactca
    18181 tgagcggtca aagtgaggcg gtgccgggcg cccgagggcc ggaggagggc ctgtcgcagg
    18241 aggcagggga gcagcaggtg ctgtcgggcg ggtacgcgcc gggcgcgcag gtgctgatcc
    18301 gtgaggatct gtggctggta cgcaagtgca cgcttacgca gcgcgacggg tggatgattg
    18361 aggtcacggg cgtttcgccg ttcgtgcgcg gcatggatgc cgtgttctac gatcgccttg
    18421 acgtcgtgca gcgactggat ccgcgcgaga ccgagctggt gccggacgac tcgccgaacc
    18481 accgccggtc ccggctcttc ctcgaagcag tcatgcgcaa gacgtccctg ccgcagaccg
    18541 agcaccggct ggcgctggcg gacaacttcc tcatggacca gcaggttcac cagctgcggc
    18601 cggcggagct ggccctgtcg atgaagaacg cgcagccccg gatcctgatc gcggacgtgg
    18661 tgggcctggg caagaccctg gagatcgggg tcctgctggc ggagctgatc cggcgtgggc
    18721 gcggtgagcg gatcctggtg gtgacgccgc agcacgtcct ggagcagttc cagcgggagc
    18781 tgtggaccag attcgggatc cccctggtgc gcctggactc gaccggtatc cagcgggtgc
    18841 agcgggacat ccccgctggc cgcaatccgt tcgcttactt caagcgcgtg atcatctcgg
    18901 tggacacgtt gaagagcgac gtgtacgcgc accatctgga gcacacggag tgggacgccg
    18961 tcgtcatcga cgagtcccac aacctggtca accgcggtac gaagaacaat gagctggccc
    19021 gtctgctggc ccgtaagacg gacgcgctgg tgctggcctc ggccaccccg cacaacggcg
    19081 acgcctcgtc gttcgctgag ctggtcagga tgctggacga ggcggcgatt gcgaacccgt
    19141 cgaagtacga ggtcgacgat ctcaggcacc tctacatccg gcgtacgaag acctccccgg
    19201 aggtccggga gtcgctcaag gagacccagt gggccgaccg gggcccttcc cggcccatcc
    19261 acgtgcctgc gtctgccaag gaactcgcgg tcttcaagga gttggccacc cgctggatcc
    19321 cctctgcccc ggacgcaccg tcggcgagcc gccatcagct cgtcccgtac cggctgctga
    19381 agtcgttcct gtcctcccac aaggccctgc tggagacggt caagacccgg atcgggaaca
    19441 tcgacaaccc accgcccgag aagtccagca acggcaagcg gcggacgcgg cccgaggacc
    19501 cggccgtacg cgaagcagcc cgggcggcgg agagggccgc cctggtcgac ctgcagcacc
    19561 tcacggagca gatcgaggac ggcgactcgg cgaagctaca agccctggtc gaggaactgc
    19621 gcgccatggg agtcggccct ggctccgaga ccagggtcgt ggtgttctcc gagagcatcc
    19681 ccaccctgcg gtggctggcc gagaccgtgc cggccgccct cggcttcgcc cacaccacca
    19741 gcacggacca gaagaagccc tggctgggct tcggcggcgc cgttctggtc atgcaccgtg
    19801 aggcgaccac ggaccaggaa cagcaggaca tcgtcgagaa gttcgggctg tacgacgacc
    19861 cggtgcgcat cctgttcacc agcgacgtcg cctccgaggg cgtcaacctg caccagcagt
    19921 gccaccacct ggtccactac gacctgccat ggtccctgat ctgcatcgag cagcgcaacg
    19981 gccgcatcga ccgttacgga cagaaacaca agcccgagtt ccgcgcgctg gtcctcacca
    20041 gtgacattcc ctggcgtacg gacgagaaca caggtgagcc gcgccccctg gacgaccgcc
    20101 tggtgggcga gaagctgctc cgacgcgagg aacaggccca ccggatcgaa ggatcagccg
    20161 aggctgtcac cggcttgtac agggccaagg aggaggagaa ccgcctcacc caggacttga
    20221 tcgcgggccg caccgtcgag gagtccatca aacagtccca gcagggcgca gccgccttcc
    20281 tcaccggcat cctcggccag gtgggcgccg tgcacgagca ccccgaggta gctcgcgccg
    20341 aggtgcccaa gctcttcgcg tccacggccg actacttcga ggtggcactg cggcaggtct
    20401 gccgccccaa ccccgaggac atgctctccc tgcgccgcga caaggacggc accatcgcct
    20461 tcgaaccccc ggcggacctg ctgtaccggc tcaaggctct gcccaagtcg tacctgaatg
    20521 agcagcagat cctgcctagc aaggacgagc ccgcccggat gcgcgtcacc ttctccaaac
    20581 agctcgcggt caagcgcctg aacgcggccc gcgagaccac cgagtcccag tggccgaacg
    20641 tctcctacgt caccgacgtc caccctgtgc tggactggct caccgacaag gtgctggtcg
    20701 agatcggccg gcacaaggcg cccgtactcg ccgccgccgt caccaccccg acgtacctgg
    20761 tccagggcat ctactccaac gccctgggca agcccaccgt cgtggaatgg atggccgtct
    20821 tcggcctgcc cgacaacccg gacgtcgagc cgctcacccc cgaactgcta gaacgctacg
    20881 gcatcagccc cgatatgccc ggccgcgcca ccccccgcga cctgcccggc ctcagtgcgc
    20941 tcgtacctgc ggcgatcgat gccgccgaac ggcacctcgc catgcgggaa gccgtgtacc
    21001 gcaagcagat cgaggcgacc ctcaaaccgc accgcgaccg agtggccgaa tggcggcagg
    21061 aggcactctt cgccagcgcc cgcccgaacg aggccgaact cgaccggacc gccaagcggc
    21121 ggctgaaact ggtcaagtcc cttcagacgg cgggcgaacc gatgctgcgc ctgctggccg
    21181 tccttgaacc caccgcgacc acctccgccg ccaccgccgt tgaaggaggc acgcagcagt
    21241 gagtaccgac ttcgactcct tcaccaaccg cggcgaatac ctctcggcgc actactttgc
    21301 cgaacaactc ggcaccgacc tgaagaaggg cctgttcacc acctgggcac agcgcgaggg
    21361 cgacgagaac gatcgccgca agaccccgcg cgaactgctg cgcaccctgc gcacccccta
    21421 cctcgccgag gaactgcgcg gctacttcgc ccagaccacc caggctgacg ccgacgacga
    21481 cgcccgcctc aacacgcaca acaaccccga gtggaccaaa cggctcgcgg aatggcacca
    21541 gatggtcctg cgcgctctcg gctacgcccc ctccccggcc gaactcaccg tgcaccgcgc
    21601 tggccgcgac cacaccctgc ccgtcgccta ccacggccac ggcattatcg ccctcgactg
    21661 cggctgggca gccgacaacg acagcgccct taacgcggag ggtgccggac acttgctcgc
    21721 ccccctccga gtcggagcga gcgaggcgta cgagacgggc ccagccctgg cctcctggct
    21781 gttccagagc gaactcggcg aagccggcgg cgagcacccc cgcttcgtcc tgctgctgtg
    21841 tggcggcgtc ctcgtgctcg ccgaccgcca cgcctggagc gagggccgct acctcgctgt
    21901 caacctcgac gcggccctgg aatgcaacga ccgcgcccaa ctgggcgaac tcgccaccat
    21961 cgccgccctg ttcagcctgg acatgctgcg gcccggcgag aacgacacca gccggccgat
    22021 cgacgccctg ctgaagtcct ccggcgacaa cgcggccggc gtctccaccg aactgcgcca
    22081 cggcctccag cactcggtcg agatcatcgc caacgaagtc ctgtaccaaa tggccgaccc
    22141 gaagaacgcc gtcacaccgc ccgacatcga aagccccaag atccccttcg cccgcgaact
    22201 cacccgcgag gcactgcgct acctctaccg aatcctgttc ctgctgtacg ccgaagcccg
    22261 ccccgaactc ggcatcctcc ccgccgacga cggctcgtac gaggccggct actccatggc
    22321 ccgcttgcgc gaactcgtcg aacgtgacga ggaactcgtc gaggaggagg cccgaaacgg
    22381 cttccacctg tacgaatccc tcaacgccct cttcaacaag gtcaactacg gtcaccgccc
    22441 ctacggcacc gaacccgacg acgaccagcc cggcgacgac gaggagaccc gcaagaccaa
    22501 gaaggcccgc cgcagcgagg atcgcggcct gcgcttcgaa cccctgcgca gcgagctctt
    22561 cgaaccgagc gccatccgcc tcatcggccg aggcgtgatg gacccgcgct gcgacgagg
//
