LOCUS       NZ_BLIS01000009        27803 bp    DNA     linear   CON 26-AUG-2024
DEFINITION  Streptococcus canis strain FU1 ScFU1_contig09, whole genome shotgun
            sequence.
ACCESSION   NZ_BLIS01000009
VERSION     NZ_BLIS01000009.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptococcus canis
  ORGANISM  Streptococcus canis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Yoshida,H., Katayama,Y., Fukushima,Y., Taniyama,D., Mizutani,T. and
            Takahashi,T.
  TITLE     Draft Genome Sequence of Streptococcus canis Clinical Strain FU1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 267874)
  AUTHORS   Yoshida,H., Katayama,Y., Fukushima,Y., Mizutani,T. and Takahashi,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2019) Contact:Haruno Yoshida Kitasato University,
            Kitasato Institute for Life Sciences, Laboratory of Infectious
            Diseases; 5-9-1, Shirokane, Tokyo 108-8641, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 6.5.1
            Genome Coverage                   :: 196x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009811695.1-RS_2024_08_26
            Annotation Date                   :: 08/26/2024 03:59:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,037
            CDSs (total)                      :: 1,982
            Genes (coding)                    :: 1,884
            CDSs (with protein)               :: 1,884
            Genes (RNA)                       :: 55
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 98
            CDSs (without protein)            :: 98
            Pseudo Genes (ambiguous residues) :: 0 of 98
            Pseudo Genes (frameshifted)       :: 42 of 98
            Pseudo Genes (incomplete)         :: 70 of 98
            Pseudo Genes (internal stop)      :: 33 of 98
            Pseudo Genes (multiple problems)  :: 38 of 98
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:23:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 133529
            Orig. end                         :: 161332
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BLIS01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27803
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..27803
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27803
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17803](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17803
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            897..1757
                     /locus_tag="GVO03_RS04780"
                     /old_locus_tag="ScFU1_09270"
     CDS             897..1757
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903404.1"
                     /locus_tag="GVO03_RS04780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09270"
                     /product="methionyl aminopeptidase"
                     /protein_id="WP_003044066.1"
                     /transl_table=11
                     /translation="MITLKSAREIEAMDRAGDFLAGIHIGLREIIKPGVDMWEVEAYVR
                     RRCKEDNVLPLQIGVDGHMMDYPYATCCGLNDEVAHAFPRHYILKEGDLLKVDMVLSEP
                     LDKSIVDVAALDFDNVPEMKKWTESYTGGLADSCWAYAVGTPSDEVKQLMDVTKEAMYR
                     GIEKAVIGNRIGDIGAAVQEYAESFGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLR
                     LKEGMVLTVEPMINTGTWEIDTDIKTGWAHKTLDGGLSCQYEHQFVITKDGPVILTSQG
                     EERTY"
     gene            1759..2724
                     /locus_tag="GVO03_RS04785"
                     /old_locus_tag="ScFU1_09280"
     CDS             1759..2724
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407653.1"
                     /locus_tag="GVO03_RS04785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09280"
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="WP_159304888.1"
                     /transl_table=11
                     /translation="MAEKKFFDKVMSKWQYEPIQAFMRHFQSAEMDLSAIAVAYYLILT
                     AFPLVIIAANIFPYLNIDISDLLRLMKQNLPKDIFRPASSIVVNIFSKPSGSVLGVATL
                     TGLWTMSRSLTSLQKAVNKAYGASQHRDFFIGHLVGLLTSLIILFLLAFALIFSTFSKA
                     AIQVLDNHYHLSDHITTVFLLLIQPITVLIIFVGLMLLYFLLPNVKIKKIRYILPGTLF
                     TSFVMTFLSNMVGNYVVHNVERMVDIKTFGSVMIFIIMLWFIFLARILILGAVFNATYQ
                     EISMGKLEGRSGDVVSILKKTLGNDADQSQASSFDEDDRD"
     gene            2854..4137
                     /gene="aroA"
                     /locus_tag="GVO03_RS04790"
                     /old_locus_tag="ScFU1_09290"
     CDS             2854..4137
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913403.1"
                     /locus_tag="GVO03_RS04790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09290"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_159304889.1"
                     /transl_table=11
                     /translation="MKLQTNVGPLRGIIKVPGDKSISHRAVILGAIAEGDTRVKGLLKG
                     EDVLSTIQAFRDLGVRIDEIEDQLIVHGQGFQGLTAPNRILDMGNSGTSMRLMAGLLAG
                     QSFEVMMTGDDSLSRRPMDRIVLPLTQMGAQVSGEGAKHFPPLKLKGSHDLRPISYSLP
                     VASAQVKSAILLAALQTRGTTQVIEKEITRNHTEEMIEQFGGQLAVEGKTIRLTGPQTL
                     VGQEVTVPGDISSAAFWLVAGLIIPSSAILLKNVGINPTRTGVLEVIERMGGQVTYENI
                     EEKSQAADLCVTYSHLKGTTISGELIPRLIDELPVIALMATQAQGTTHIKDAQELRVKE
                     TDRIQVVTDILNSMGANIEATADGMMIQGPTPLHGTQTSTFGDHRIGMMTAIAALLVSQ
                     GEVILEREETIMTSYPSFFTDLERLCHG"
     gene            4130..4621
                     /locus_tag="GVO03_RS04795"
                     /old_locus_tag="ScFU1_09300"
     CDS             4130..4621
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922406.1"
                     /locus_tag="GVO03_RS04795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09300"
                     /product="shikimate kinase"
                     /protein_id="WP_138114231.1"
                     /transl_table=11
                     /translation="MVKVLLGFMGVGKTTVSKQLDGQCKDMDAIIETQIGMSIASFFDQ
                     YGEEAFREIESQILRQLLLEKEDIVIVTGGGVVVSEENRRLLAANRQHNILLVASFEVL
                     YQRLQEDSLSQRPLFLKYTKEEFHQLYKRRMALYEGLADLVIHVDYRRPEEVAKLIAAF
                     "
     gene            4848..6347
                     /locus_tag="GVO03_RS04800"
                     /old_locus_tag="ScFU1_09310"
     CDS             4848..6347
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012767185.1"
                     /locus_tag="GVO03_RS04800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09310"
                     /product="LCP family protein"
                     /protein_id="WP_159304890.1"
                     /transl_table=11
                     /translation="MTKYTSGGLSHHEELRYFYLLRNLTYLSENEKREFAFLKSKMEAG
                     RTHSSSSKSRSEVRQPTSYPVDDYYQGDYPKTYLDQTYTEEGAPLGPSGLPLYPREENR
                     RSKRQAKVATRQAMVSQEPVYGYCQEYPQDLNPRYGDYTYQEDYADPTPLPKTKKRSRK
                     KKSYLKGFFKLIGLLLLVMVLGLGFMFAKGIFEVSTNKVNYKPAVSQAFNGKETKDGTN
                     ILILGSDQRVTQGSTEARTDTIMVVNVGNKDKKTKMVSFMRDTLVNIPGYSYNDNDSYD
                     LKLNISFNLGEQENHHGAEFVRQTLKHNFDIDIKYYVMVDFETFAEAIDTLFPNGVTID
                     AKFATVGGVAVDSVEVPDDLRMKDGVVPNQTIDVGEQQMDGRTLLNYARFRKDDEGDFG
                     RTVRQQQVMSAVMSQIKDPAKLFTGSAAIGKIYALTSTNVSFPFVLKNGVSILGSGKNG
                     VEHVTIPENGDWVDEYDMYGGQALHIDFDKYQKTLAKLGLR"
     gene            6430..7785
                     /gene="rlmD"
                     /locus_tag="GVO03_RS04805"
                     /old_locus_tag="ScFU1_09320"
     CDS             6430..7785
                     /EC_number="2.1.1.190"
                     /GO_function="GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rlmD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057779.1"
                     /locus_tag="GVO03_RS04805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09320"
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="WP_308686687.1"
                     /transl_table=11
                     /translation="MLTKNDIIQVEISDLSHEGVGVAKHDGLVFFVDNALPGEVIDMRV
                     LKINKNRGFGKVEAYHRLSSARNRDVNLAYLRTGIADLGHLAYEDQLVFKQKQVQDSLY
                     KIAGISDVAIESTLGMAEPLAYRNKAQVPVRRVNGQLETGFFRKHSHELVPISDYYIQN
                     KDIDCLINFVRDLLRRFDVKPYNEIEQTGLLRNIVVRRGHYSGEMMLVLVTTRPKVFRV
                     DQVIEKIVEAFPEVVSIIQNINDKNTNAIFGKEFRTLYGRDTITDTMLGNRYEISAQSF
                     YQVNTVMAEKLYQTAIDFSELSKDDVVIDAYSGIGTIGLSFAKTVKAVYGVEVIEAAVQ
                     DAQKNAALNGITNAHFVADTAENAMATWAKDGIKPDLILIDPPRKGLTESFIQASVAMA
                     PNKITYVSCNPATMARDIKRYEELGYQLKKVQPVDLFPQTHHVECVALLVKA"
     gene            complement(8402..9253)
                     /locus_tag="GVO03_RS04810"
                     /old_locus_tag="ScFU1_09330"
     CDS             complement(8402..9253)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985634.1"
                     /locus_tag="GVO03_RS04810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09330"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_159304892.1"
                     /sec_met_domain="TIGR01716 (E-value: 7.1e-63, bitscore:
                     206.1, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKLGITLKKVRKGKQISLCSVADEHLSKSQISRFERGESEISC
                     IRLINILDKLHITLEEFLILHNEDYTNGESFANLVQYIRKQYSSQSINNIACLLYDTSN
                     YTLNSLEKTMVKSILHTMDSNVIPSDEELLQLTDYLFKVEKWGYYEIILLGNCVRTINY
                     NSYFLLTKEMLNNYIYSSLNKTNKRIVTQLAINCLILSIDKEKFSNCSYLIDEIKALLD
                     NELNFYEQTVFLYATGYFEFKRQSGTGIEKMKQAIQVLDILGEDKLKLHYTDHFDKLVN
                     KE"
     gene            9335..9406
                     /locus_tag="GVO03_RS10650"
     CDS             9335..9406
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033797.0"
                     /locus_tag="GVO03_RS10650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SHP2/SHP3 family peptide pheromone"
                     /protein_id="WP_138284062.1"
                     /transl_table=11
                     /translation="MKKISKLVPILVLVMDIIIIVGG"
     misc_feature    9376..9391
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.91"
                     /tool="antismash"
     misc_feature    9378..9392
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.18"
                     /tool="antismash"
     gene            9602..9769
                     /locus_tag="GVO03_RS04820"
                     /old_locus_tag="ScFU1_09340"
     CDS             9602..9769
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010890685.1"
                     /locus_tag="GVO03_RS04820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09340"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_050197451.1"
                     /sec_met_domain="mature_ha (E-value: 6.5e-15, bitscore:
                     48.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKHSEVTLENEILFQEFDEDVFGACTTNTFSLSDYWGNKGNWCT
                     LTHECMNWCK"
     CDS_motif       9602..9676
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDKHSEVTLENEILFQEFDEDVFGA"
                     /locus_tag="GVO03_RS04820_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9677..9769
                     /prepeptide="core"
                     /locus_tag="GVO03_RS04820_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="3418.8"
                     /monoisotopic_mass="3416.5"
                     /core_sequence="CTTNTFSLSDYWGNKGNWCTLTHECMNWCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDKHSEVTLENEILFQEFDEDVFGA"
                     /leader_location="[9601:9676](+)"
                     /alternative_weights="3436.8"
                     /alternative_weights="3454.8"
                     /alternative_weights="3472.9"
     misc_feature    complement(9628..9642)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.47"
                     /tool="antismash"
     misc_feature    9634..9648
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 24.71"
                     /tool="antismash"
     gene            9784..9984
                     /locus_tag="GVO03_RS04825"
                     /old_locus_tag="ScFU1_09350"
     CDS             9784..9984
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="GVO03_RS04825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09350"
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_159304893.1"
                     /transl_table=11
                     /translation="MEQNNLELGKYLESDLLSLTDENVDGGTTPASPATPYTPAIGKGV
                     IAVTAFVSANTCPTSACTRAC"
     CDS_motif       9784..9864
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEQNNLELGKYLESDLLSLTDENVDGG"
                     /locus_tag="GVO03_RS04825_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9865..9984
                     /prepeptide="core"
                     /locus_tag="GVO03_RS04825_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.60"
                     /molecular_weight="3600.1"
                     /monoisotopic_mass="3597.9"
                     /core_sequence="TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEQNNLELGKYLESDLLSLTDENVDGG"
                     /leader_location="[9783:9864](+)"
                     /alternative_weights="3618.1"
                     /alternative_weights="3636.1"
                     /alternative_weights="3654.2"
                     /alternative_weights="3672.2"
                     /alternative_weights="3690.2"
                     /alternative_weights="3708.2"
                     /alternative_weights="3726.2"
                     /alternative_weights="3744.3"
     gene            10001..12922
                     /gene="lanM"
                     /locus_tag="GVO03_RS04830"
                     /old_locus_tag="ScFU1_09360"
     CDS             10001..12922
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="GVO03_RS04830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09360"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_159304894.1"
                     /sec_met_domain="DUF4135 (E-value: 1.1e-64, bitscore:
                     212.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.3e-43, bitscore:
                     141.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGYDKDIYPELKSESEFNEYISPIIEGIKHLTITGEIVSQSKND
                     FINIEETYPYHNSCLFFVDNIWKKLWNDKLNNLLFDSEDFKEAICESLAQVAFTYFIRC
                     FANQIKEYSTNTDIKKNYKEYSRFLIDNCFKNFSSEYPVIWYRCNKLVINKVNYIIIVL
                     NTLTKSRDKIQNKFKISKQLRVKNILMDGDSHNCGKTVSTIIFENGEKLIFKPRTVDGE
                     YGYAKLVNELNMAFKTNFLAVDTLKVGKYGFCSFVEIDDSSIDMVKAGKLACLLYLLNA
                     TDMHYSNIYWTKEGPIPIDLETLFHVPRLKKGLEESQKSAYKYIEQSVYSTGVLPINLV
                     SKNGTVDVGFTGVRNSNSIGPIKSIELLDGFTSNIRFIWGKYPSTTNMKNNISENLQIF
                     QNCDEVSKGFSEMYELVFNNKEWFLNTVSKIFSNSKVRYIHNMTYRYEQILRTLTSTKA
                     SKSESLSKSILSRLGVLSLTCEKPIIISECQQIWNGDVPYFTANYSENYIYDYDEKIIA
                     RTNSSPKSNFEDKIKSLSIKDLNEQLKIIKLAFVAKVQDPHGENAEAFKLKNSLKTSNE
                     IIKLLSDKLMNSVYDDKYEHLPKTWIGPVSTHTTNGWAPGVLGYDMYGGRTGIALVLAL
                     AGTKLGETRYSDLAFQIFEAYAKILESNVYETRSILSSGIGLYSGFPSVIWGLYEASHI
                     FKEEKWKKIAIDSWKIIDEEICSVKSGFFDMMSGNSATIIMRLKMDKEFQLNNYQIELF
                     ISEALKVLENRNERTTSGLVHGISHLIWFFSIIYQTYPTAAVRELINDCLKILKENYYS
                     EKEEINIYERTDYQSDSWCNGVSGVLLAYYEGFKAGIVDKKDVSLLLQQLKRLRITTLP
                     VYCHGILGILEVLNYMKSDFLEDVSSILFMADFKGDFSNVIYHYFKSEKGRYTLSPGFM
                     SGISGAVYYLCKLNIDFKISPITLEKHYEDEKKTNSNTANCTN"
     gene            12879..15020
                     /locus_tag="GVO03_RS04835"
                     /old_locus_tag="ScFU1_09370"
     CDS             12879..15020
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016615515.1"
                     /locus_tag="GVO03_RS04835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09370"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_231146900.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.6e-36, bitscore:
                     117.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKKLIPTLQIAQTECGLCCVRTILEYYGFDISITELRQIEEPGR
                     DGLSTKHLKKLLQKFNLTSNTYKINNPNAFKVIDFPVIAFWKGYHFVCIEKIENNHAFI
                     MDPSIGRVKIDLKDFFENFSEIIIASYPNETFRKRKKSFAKRYNYRKLIPSDILNNYLG
                     LIITSVLVIAINISIPVLTQLLIDSVQTNNYDFRYIILSIVFLGIVSGTVFYFKSVLSI
                     TLMKNFSWHLLSTAFNRILSLPSKYFTVRSPGEIVYRLNSLTRIQDLFGTSLIQLFLDI
                     ISLFAILIYLSGVSIILTGVELLFILLLFTLLINLQPKIQSTSDNELHQASLAQSIQLD
                     AIVSINNIKLGGYKEAYKEDWASKYKKSLDYTAERMNIQQSWIGTILGMVSAFVPLVIL
                     SMALFQFSLGRLSLGEAIATQTVTSLLYNYANSIFTTFSNFSVLNRYVDLAEDIYEYPI
                     ENSGDIKYQIFKDELVLDNVSFSYSGNNIYALRSINLKIKKGETIALVGESGSGKSTLG
                     KIISSLFMPTIGTIYLDGISYKDYELDSFRNRIGYIPQESYLHNRSIIDNIALGCETER
                     DEIIKKCKNIPFLDFINNLPMGYNTQISEMGGNLSGGQRQRIQIAKILIKQPELLIMDE
                     ATSSLDNVSQKYVYDELNVMNCTKIIIAHRLETILNADKIIVLESGKISQVGTHDQLIT
                     EAGGLYSKLFTAENLENKK"
     gene            15017..17803
                     /locus_tag="GVO03_RS04840"
                     /old_locus_tag="ScFU1_09380"
     CDS             15017..17803
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024964.5"
                     /locus_tag="GVO03_RS04840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09380"
                     /product="DUF4135 domain-containing protein"
                     /protein_id="WP_159304896.1"
                     /sec_met_domain="DUF4135 (E-value: 2.2e-68, bitscore:
                     225.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.9e-27, bitscore:
                     90.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISESSKVIESVINYFESDINKAKELLISKINQSNGGDKIIENFI
                     DVLYDLIAKQAWRIINKTFVYEFHEFRKQKGLPISKTSSLAYEMFLSEMNKDVIGKWLK
                     KYTVLHGILQDSILNSCKFITEVFYYYAEDKSLLIDRGFLGKDAQINKITLLDSDPHNN
                     GKIVLLFEDTDCRKFIFKNRDFKIDNLINDIFKTLFLNAQKNMESPIPQNIIRDGYGWQ
                     KFVEQVPVLRANVGVSFYNLGYYSVLFSVLGASDLHDENLIFRGEVPYFIDLETALHPR
                     LNSTEQSLIGELQNSITKSIAHTTIIPSKLLNNSYNYLIGAINTPYPQETEKMVFSFKN
                     LGTDAIDIAKEKVVLDRLATPLSCTDGKIIDPVNYYDDFLSGYKSGFIDIMNNKTMISK
                     KVESFKGDIRVVLRPTAQYFLIMDACLYPENLIDYSSAKKILHYLKPISFIKDKTIAKM
                     IYDEECKSLLQGDIPYFKVESDSLNLVINSNTYKRVYSVSAITNALENLKCLSDSQLLF
                     DYRLISEGFSEIKIRNSKKGNVNRDNSKMYIDLLRDLKNGNFEKILDWWKAQSVLYEMN
                     NTKYRAWHNGSYGELPSLYSTPTLISFHDIGGVEIMLESLLLAKGTSNSRVIFEEARNG
                     LIKLRDEVYAGGSGDYHSIIAGEESVDFILSKSDKQVRNLELKVKNSEIPIGDVFNGKL
                     GIYLVLASYSRTCLDTMVQGEIELANSSSDYSKFGLAHGKLGELWTKFRIYAKLDLNKE
                     CMRIYSETLKCYKNGKILPGWCNGYSGLLMVLVEMSKVLNIKIDYFELALKCVDLPENA
                     SIDLSVCHGTSGVIQSLLFCYIVTKDKRYIELADSYWNLVYKKAQSDGFYIGESNREYL
                     LGYMMGWSGVIDTILLLNLLKDGRQHWIPLNLSTIDYQEQLKKETFNVIGCSVKSKA"
     gene            17769..18884
                     /locus_tag="GVO03_RS04845"
                     /old_locus_tag="ScFU1_09390"
     CDS             17769..18884
                     /NRPS_PKS="Domain: PKS_ER (46-229). E-value: 1.6e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_GVO03_RS04845_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012335.5"
                     /locus_tag="GVO03_RS04845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09390"
                     /product="zinc-binding alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_159304897.1"
                     /transl_table=11
                     /translation="MLSVVALNPKHDIINKAFNVVYINFGNIQIPFGLIEFEQPVFDLN
                     DPKNDDYLLIKVNSFSCNYRDKAILVNNFEQLLRLGKPFLPFGSEFSATIVLKGKNVDE
                     FGIGDKVIPNCTYEGVTNDNVVPGVTTNFASLGWLRIRREKLIKQPHELSDLEAACFSL
                     GAQTAYSMIRKSGILEKQNKKAVVFSSRSVTSLFIIQLLNYFGIDLVCCSSSEWSKEEL
                     DSIGIKKVVSVDGIEEYLDSFSHVFDPYFDLNFSRAVSLLGNGGKYVFCGFLNQHPVLS
                     KEDDKTLNTEEIFNSLKLVIVKNISLIGNCLGSQEDLNKVIEIYGSEISPTIDSEYNLG
                     QLEEFLTRSFFDKNKFGKCVIDYSREGVTYV"
     aSDomain        17907..18455
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GVO03_RS04845_PKS_ER.1"
                     /evalue="1.60E-10"
                     /label="GVO03_RS04845_PKS_ER.1"
                     /locus_tag="GVO03_RS04845"
                     /protein_end="229"
                     /protein_start="46"
                     /score="32.6"
                     /tool="antismash"
                     /translation="PKNDDYLLIKVNSFSCNYRDKAILVNNFEQLLRLGKPFLPFGSEF
                     SATIVLKGKNVDEFGIGDKVIPNCTYEGVTNDNVVPGVTTNFASLGWLRIRREKLIKQP
                     HELSDLEAACFSLGAQTAYSMIRKSGILEKQNKKAVVFSSRSVTSLFIIQLLNYFGIDL
                     VCCSSSEWSKEELDSIGIKK"
     gene            19051..19905
                     /locus_tag="GVO03_RS04850"
                     /old_locus_tag="ScFU1_09400"
     CDS             19051..19905
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018366183.1"
                     /locus_tag="GVO03_RS04850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09400"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_065361263.1"
                     /transl_table=11
                     /translation="MELYNVVKKFKNHVVLNDISFEINKGEIVGLVGKNGAGKSTLMKI
                     ISKLDTNFEGKIDEVGRLGYFIESPKLVTNRTGLWNLKYFSYIFGNKFLIEDYFDFYQS
                     IEIIDFLKQKVKKYSLGMKQKLGVLIALLNNPDYVILDEPTNGMDIDSSIVFLQELKKI
                     VKEKNIGVFISSHKLEDIELICDRIIFLNNGKLEKLNSREYKNRIIHKLIFRDKNDVDL
                     FLKNQNIGIITESQDDFIKIETSCSYSELMDLINKLNISLLDYSYEQKTLRDIYIDKII
                     KGD"
     gene            19910..20638
                     /locus_tag="GVO03_RS04855"
                     /old_locus_tag="ScFU1_09410"
     CDS             19910..20638
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GVO03_RS04855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ScFU1_09410"
                     /product="ABC transporter permease"
                     /protein_id="WP_159304898.1"
                     /transl_table=11
                     /translation="MKFNKRLYIKNCLKELITSGIIIIGVIVAVIPPVILMYYIINYGS
                     NSFYIKHISNFFCIFGLYIGVLSPLYFINRDFSMDTIALVCNTKENRIAYLNANVLLAF
                     FLSLFYSSIGVATVLIANYLGVTGDLTVNFIIGFFCNLTITIIFYYLFSYLLFSFFIKS
                     NVVFSFLTLLLLFIPNIISNILYSTQNELLNNLFEKIPMYFLPIYAGSNIMEVSQYIIS
                     ILSICILYTLSMKKTLNLRF"
     misc_feature    20642..20657
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 20.43"
                     /tool="antismash"
     gene            <20655..20896
                     /locus_tag="GVO03_RS10315"
                     /pseudo=""
     CDS             <20655..20896
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407401.1"
                     /locus_tag="GVO03_RS10315"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="macrolide ABC transporter permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="LSEFVNKHLSSKRLMIFLALYSLMLMLATPLYFMFHNVIIRTFSR
                     "
     gene            complement(21016..21222)
                     /locus_tag="GVO03_RS04860"
                     /old_locus_tag="ScFU1_09420"
     CDS             complement(21016..21222)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018659567.1"
                     /locus_tag="GVO03_RS04860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09420"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_159304899.1"
                     /transl_table=11
                     /translation="MKFSYNKLWKLLIDKGWTKSELRQKAGISSSTIAKLGKGENVTTD
                     ILLKICIALDCKIEDIIEIVNSK"
     CDS_motif       complement(21139..21222)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKFSYNKLWKLLIDKGWTKSELRQKAGI"
                     /locus_tag="GVO03_RS04860_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21016..21138)
                     /prepeptide="core"
                     /locus_tag="GVO03_RS04860_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="4163.9"
                     /monoisotopic_mass="4161.3"
                     /core_sequence="SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKFSYNKLWKLLIDKGWTKSELRQKAGI"
                     /leader_location="[21138:21222](-)"
                     /alternative_weights="4181.9"
                     /alternative_weights="4199.9"
                     /alternative_weights="4217.9"
                     /alternative_weights="4235.9"
                     /alternative_weights="4254.0"
     gene            complement(21212..22870)
                     /locus_tag="GVO03_RS04865"
                     /old_locus_tag="ScFU1_09430"
     CDS             complement(21212..22870)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904398.1"
                     /locus_tag="GVO03_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09430"
                     /product="DUF2326 domain-containing protein"
                     /protein_id="WP_159304900.1"
                     /transl_table=11
                     /translation="MLIEMWSPVFKKNGQTRKPVRFHPGLNVIMGMDLADNSIGKSSSL
                     LAIDFIFGGNSYQKSIAVKKLGDHPIYFCFQFEKKFYFSRDTANPDIITYCNDDYSPTG
                     ETMPLEIFLNKLKKRYHLDSPNLSFRLAMSGFFRIAGKSNQNTDFPLQVYSSQKSSESI
                     ITLIQLFNLYDNIARYKERLKDKSDQLTTFRNARKYAFISNLVGGKKQFEANVSEIKSL
                     EYDLSHLQDTQQDKIDSGDIEKNQQKIQLRNTKLELENSLRDKQRRLKLLDISIEFGLY
                     PTESDLTELQQYFPDTNLKKLYEVEAYHKKLANILDSEFSIERESLIAEIDELESQLTI
                     LNQELQELGNIPNLSSEYLENYSKLTATINALKEQNEAYLKESSLSKEKSEADADLKRS
                     TEDILLDLEVKINSKMHEFNNILYPDIRKAPQINLKAHNSYSFYTPDDDGTGTKFKGMI
                     LFDLTMLYLTNLPALAHDSLLLSNISYQATEALLKLYDQSKSLNKQVFLAFDKASSYSP
                     EANQLLSENTVLRLSSNGNELYGISWNKGENSDEV"
     gene            complement(22861..23085)
                     /locus_tag="GVO03_RS04870"
                     /old_locus_tag="ScFU1_09440"
     CDS             complement(22861..23085)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176804.1"
                     /locus_tag="GVO03_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09440"
                     /product="ABC-three component system middle component 7"
                     /protein_id="WP_001176803.1"
                     /transl_table=11
                     /translation="MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHAISEELDD
                     PTDFLSIMDCLYALNAIEMSNEGEVKLCL"
     CDS_motif       complement(22972..23085)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA"
                     /locus_tag="GVO03_RS04870_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(22861..22971)
                     /prepeptide="core"
                     /locus_tag="GVO03_RS04870_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="3963.5"
                     /monoisotopic_mass="3960.9"
                     /core_sequence="ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA"
                     /leader_location="[22971:23085](-)"
                     /alternative_weights="3981.5"
                     /alternative_weights="3999.5"
     gene            complement(23085..24203)
                     /locus_tag="GVO03_RS04875"
                     /old_locus_tag="ScFU1_09450"
     CDS             complement(23085..24203)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000347290.1"
                     /locus_tag="GVO03_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09450"
                     /product="ABC-three component system protein"
                     /protein_id="WP_159304901.1"
                     /transl_table=11
                     /translation="MDFPTYFRILKKYLGDGATIPEFFRELIEMITEDDAEEIISASEI
                     TSEKTDSTLVSYAKRGFTKKMANQLICKINSINMKDSIESRPDETIQLLANEFNSYYPD
                     ITAKNASLRIPEIFVDFIREKAGMGTATTAQKASFITQSNQLKKQYGQFLLTEANNCCA
                     FPGCDRPLILTRGNLATESYEVSVIEKDKVPEPLNLIALCPDCFLTYQTDNRKKTVASL
                     KNIKKILVSAKNSQQSISDMKLDSGIVSVLTSLNKLKFDEYDISYDPKQLTDKISPEKN
                     RMLYQMVKNQVIDNYLTIQKIIINLDKQGRIDYEEIQYQMRSMYKKLKAAKHDNLTIFN
                     TISEKLHKATLQDIYFCQMIVSYFIQKCEVLE"
     gene            24636..25232
                     /locus_tag="GVO03_RS04880"
                     /old_locus_tag="ScFU1_09460"
     CDS             24636..25232
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648121.1"
                     /locus_tag="GVO03_RS04880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09460"
                     /product="hypothetical protein"
                     /protein_id="WP_154700307.1"
                     /transl_table=11
                     /translation="MTNKDNIYNECQKQECSLEVGLLEGQVLAPMLVENQQVIEDMRLK
                     RETLRSWRPAKQLNVYVLVAFIPVFPEEFAKTERIYKDAVENFLNEFRTRKSKNIEEII
                     SYEAWIDMDESTLYSSTEELEEFMFAEMLQDLLEKVKQADKDLYDITLGLLAKEFDESI
                     EDVFIKIGVKRSTGFYRLPKARALVAALLKELNPK"
     gene            25473..25982
                     /locus_tag="GVO03_RS04885"
                     /old_locus_tag="ScFU1_09470"
     CDS             25473..25982
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000544985.1"
                     /locus_tag="GVO03_RS04885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ScFU1_09470"
                     /product="type III toxin-antitoxin system ToxN/AbiQ family
                     toxin"
                     /protein_id="WP_154700308.1"
                     /transl_table=11
                     /translation="MHEMKFYQIDTNYLNILRQIDGRVPHNKEFIGRKGKSRPYIGVML
                     SIDNVDYFVPLSSKKKRSSFVVMPIYDDNDEQIATLMLNNMLPVPPKHRKLLNMDGVRI
                     TDPKYFDLLMNELNFLRPRRQAIKSRCTIIRSVKVEGKNKPQINKKTKEFCLNLLELEE
                     AYKENE"
     misc_feature    complement(25490..25504)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.54"
                     /tool="antismash"
     misc_feature    25497..25512
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 23.75"
                     /tool="antismash"
     misc_feature    complement(25506..25520)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 23.95"
                     /tool="antismash"
     misc_feature    complement(26068..26081)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    complement(27569..27578)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.05"
                     /tool="antismash"
ORIGIN
        1 atgctatttt ggtaacaggt ggatttccag tctctaaacg tgtcattgaa acggcagata
       61 gtcaaggaat ccctgtaatg gtgaccaatt acgatacctt tacagttgcg accatgatta
      121 accatgcctt gtctaatatc cgcatcaaaa cagaccttaa aactgttgaa caggtcatga
      181 ttcctgtcga ggactatggt tgtctgtatg aggataatgc cattgaagaa ttcaatactc
      241 tcatcaaaaa gacacgacag gtaaggtttc cagtactaga tcacaaggca aaggtaattg
      301 gtgtggtcag tatgcgtgat gtggtggatc agttgccaac taccaagctt accaaggtca
      361 tgtctaaaaa tccaattaca gctaaaccaa ataccagtct tgcaaatatc agtcaaaaaa
      421 tgatttttga agacctaaac atgttacctg tggttgatga agagcatgct ttgctgggga
      481 ttattacccg cagacaagcc atggaaaacc ttcctaacag ccaaccaagt aacctatata
      541 catacagtga acagattttg tcaagccttg aagagactct tgattattat caggtactga
      601 ttgagccgac catgattgat agcactggta acatgtcaaa tggggttatt tcagagtttc
      661 tcaaagaaat cagtgttcga gtgctgacga aaaagcatca aaaaaatatc attattgaac
      721 aaatgatgat atacttttta catgctgttc aaattgatga tcaattaaag atatatccca
      781 aaattattac ggaaaataga cgaagcagta ctattgatat cgaaattttt gtcgatgctc
      841 aagtgattgc caaagctatt attacaacga aaataaatta gaggagaaac aaaacaatga
      901 taacattgaa atctgcccgc gaaatagaag cgatggatag agcaggagac ttcttagcag
      961 gtattcatat tggcttaaga gagattatta agcctggtgt ggacatgtgg gaagtggaag
     1021 catacgttcg tcgccgttgt aaagaagaca acgttcttcc tttgcaaatt ggggttgatg
     1081 gtcacatgat ggactatccc tatgcgacct gttgcggctt aaatgacgaa gtagcgcatg
     1141 cctttccccg acattacatt cttaaagaag gagatttgct taaagttgac atggtattaa
     1201 gcgagccttt ggataaatca attgttgatg tagcagcttt agattttgat aatgtgcctg
     1261 agatgaaaaa atggacagag tcttatacag gtggtttagc tgattcgtgc tgggcttatg
     1321 ccgttggaac accatctgac gaagtgaaac aattgatgga cgtgaccaaa gaagctatgt
     1381 accgtggcat tgaaaaagca gtgattggca atcgtatcgg cgatattggc gcagctgttc
     1441 aagaatatgc ggaaagtttt ggttatggtg tcgtgcgtga ccttgtagga cacggtgttg
     1501 gaccaaccat gcacgaagag ccgatggtac caaattatgg gacagcgggt cgtggtcttc
     1561 ggctaaaaga aggaatggtc ttgaccgttg agccgatgat taatacagga acttgggaaa
     1621 ttgacactga catcaaaaca ggttgggctc acaaaaccct agacggtggc ttatcttgcc
     1681 agtatgaaca ccaatttgtg attactaaag atggtccagt tatcttaaca agtcaggggg
     1741 aagaaagaac ttactaaaat ggcagaaaaa aaattctttg ataaggtgat gtccaagtgg
     1801 caatatgaac cgattcaagc ttttatgagg cattttcaaa gtgcagagat ggatttgtct
     1861 gccattgcgg ttgcctatta ccttatcttg acagcctttc cattggttat tattgcagcc
     1921 aatatctttc cttatctcaa tattgatatt tcagacctct tgcgtttgat gaaacaaaac
     1981 ctacctaaag atatttttag gccagcttct tcgattgtgg tcaatatctt ttctaaacct
     2041 tctggcagtg tcttgggagt ggcgactttg acgggtttgt ggaccatgtc acgaagtttg
     2101 acctccttgc aaaaagctgt taataaggcg tatggagctt ctcaacatcg agatttcttt
     2161 atcggtcatc tggttggtct attgaccagt ttgattattt tgttcttatt agcctttgcc
     2221 ttaatttttt caaccttttc aaaggcggcc attcaagtgt tggacaacca ttaccatttg
     2281 agtgatcata tcacgacagt tttcttactc ttaattcagc cgattaccgt tttgattatt
     2341 tttgtcggct tgatgctatt atattttttg ctacccaatg ttaagattaa aaaaattcgt
     2401 tacattttac cgggaacctt attcacatct tttgtcatga cttttttgag taatatggtt
     2461 ggcaactatg tggtgcataa cgttgaacga atggtggata tcaaaacttt tggttcggtg
     2521 atgatcttca ttatcatgtt atggtttatc ttcttagcca gaattttgat tttgggagcc
     2581 gtctttaacg ctacctatca ggaaatttcc atgggcaagc ttgaaggacg cagtggtgat
     2641 gtggtctcca ttctcaaaaa aaccttgggc aatgacgccg accagtccca agcttcctct
     2701 tttgatgaag acgacaggga ttaaagaaag catgtcaacg atgaatgaag taggaaagtt
     2761 ctttcttact tcatttttta tcaacaggct ctgactggca gagcattcag cggttgaagg
     2821 agcctaaaag ataagaaaca gtgaggcaaa acgatgaaat tacaaacaaa tgtaggcccc
     2881 ttgcgaggaa taattaaggt tccgggagac aagtctatta gtcaccgagc agtgatttta
     2941 ggggccatag cagaaggaga cacaagagtg aaaggtttgt taaaggggga agatgtgctt
     3001 tctactatac aagcctttag agatttaggt gttcgtattg acgaaataga ggatcaactt
     3061 atcgtacatg gtcaaggctt tcaagggcta acggctccca atcgcattct tgatatggga
     3121 aattctggta cctccatgcg cctgatggct ggattattgg caggacaatc ttttgaagtg
     3181 atgatgacgg gtgacgatag tttatcaagg cggccaatgg atcgtattgt tcttccctta
     3241 actcaaatgg gtgctcaggt atcaggagaa ggtgctaagc atttcccccc tcttaagtta
     3301 aaaggaagcc atgatttacg accaataagc tattctctac ctgttgcttc tgctcaggta
     3361 aaatcagcta ttttattggc agctctgcaa acacgtggaa ccacacaggt gattgaaaaa
     3421 gaaataaccc gtaatcatac cgaggaaatg attgagcaat tcggtgggca acttgctgtt
     3481 gaaggaaaaa cgattagatt gactggtcct cagaccttag tagggcaaga agtgactgta
     3541 ccaggagata tttccagcgc tgccttctgg ttagtggcag ggctgattat tcccagctca
     3601 gctattcttc tcaaaaatgt cgggatcaac cctacaagga cgggtgtttt agaggtgatt
     3661 gaacgaatgg gtggacaagt cacttacgaa aacattgagg aaaagtccca agctgctgac
     3721 ctttgtgtga catattctca tttaaaagga accacgattt caggagaact tattccgcga
     3781 ttgattgatg agttgcctgt tattgctctg atggccacac aggcacaagg tactactcac
     3841 attaaagatg cccaagaatt acgggtcaaa gaaacagatc gtattcaagt ggtaaccgat
     3901 attcttaata gtatgggtgc taatattgaa gcgacagctg atggtatgat gattcaaggt
     3961 ccgacccctc ttcatggaac ccaaacaagt acctttggag atcatcgaat tggcatgatg
     4021 acagctattg cagctttact cgtatcacaa ggggaagtta ttttggaaag agaagagact
     4081 atcatgacgt cttacccaag ctttttcacc gatttggaaa ggttatgcca tggttaaagt
     4141 tttattaggg tttatgggag taggcaaaac aaccgtttca aaacaattgg acggccagtg
     4201 caaagatatg gatgccatca ttgagactca aattggcatg tcaattgcga gtttttttga
     4261 tcagtatgga gaagaagcct tcagagagat tgaaagccag attttgagac agctgctctt
     4321 ggaaaaagag gatattgtga ttgttacagg tggcggtgtt gtggtttcgg aagaaaatcg
     4381 tcgcttgttg gcagcaaatc ggcagcataa tattctactg gttgcttcct ttgaagtcct
     4441 ctaccaacgc ttgcaagagg atagcctatc tcaaaggcct ctttttctca aatacactaa
     4501 agaagagttt catcagcttt acaagcgtcg tatggcactt tatgaaggtc tagcagattt
     4561 agtgattcat gttgattatc gtagacctga agaagtcgca aaactaattg ccgcttttta
     4621 agtttgtttc tttggcaaaa tagttaatgt cacagaggtc agctgttttt tggaaggtct
     4681 attagaacac caaggttcta atggttgttt attaaaaaat cagtaaataa aactagttaa
     4741 tctgctatca ttaaaatttt gagaggacaa tctgaccatt ataggttata atagaagtgc
     4801 tagttaaaaa gaatagattg tattgtaata ctaagagatg acatgatatg acaaaataca
     4861 ccagcggtgg ccttagtcac catgaagaat tgcgttattt ttatctccta aggaacctaa
     4921 cttaccttag tgagaatgaa aaaagagagt ttgctttttt aaagtcaaaa atggaggctg
     4981 gtcgtaccca ctctagttct tcgaaaagtc gaagtgaggt aaggcagccg acttcctatc
     5041 cagtagacga ttactaccaa ggggattatc ccaaaactta cctagaccag acttacactg
     5101 aagaaggagc acccttaggt cctagtggct tgcccttata tcctagggaa gaaaaccgcc
     5161 gctcaaaaag acaggctaaa gtagccactc gtcaagccat ggttagccaa gaaccagtct
     5221 atggctattg tcaagaatat ccccaagacc tgaacccgag atatggtgat tatacttatc
     5281 aagaagacta tgctgaccca acaccactgc caaagactaa aaaaagaagc cgcaagaaaa
     5341 agagctacct gaaggggttt tttaaactga ttggcttact gttactggtc atggtcttag
     5401 ggctcggttt catgtttgcc aaaggcattt ttgaggtgtc tactaacaaa gtcaattaca
     5461 agccagctgt ttctcaagcc tttaacggca aagagaccaa agacggaacc aatatcctta
     5521 ttctaggttc tgatcagagg gttacccaag gctctaccga agctcggaca gataccatta
     5581 tggttgttaa tgtcggcaat aaagataaaa aaaccaaaat ggtctccttt atgcgagata
     5641 ccttggttaa cattccagga tatagttata atgataatga ttcctatgac cttaagttaa
     5701 acatttcctt caatttagga gaacaagaaa atcatcacgg ggcagaattt gttcgccaaa
     5761 ccctcaaaca taattttgac attgacatca agtattatgt gatggttgac tttgaaacct
     5821 ttgcagaagc tattgacaca cttttcccta atggtgttac aattgatgct aaatttgcaa
     5881 cagtaggtgg tgtagccgtt gactccgtag aagttccaga tgatttacga atgaaagatg
     5941 gggttgttcc caaccaaacc atcgacgttg gagaacaaca gatggacggt agaaccttgt
     6001 tgaattatgc ccgttttcgt aaagatgatg agggagattt tggacgaacc gtccgtcagc
     6061 aacaggtcat gtcagctgtt atgtcccaaa ttaaggaccc agctaaactc tttacaggtt
     6121 ctgcagccat tggtaaaatt tatgccttga cttcgaccaa tgtttccttt ccttttgtcc
     6181 tcaaaaacgg ggtttctatt ttaggcagtg gaaaaaatgg ggttgagcac gttaccatcc
     6241 cagaaaatgg cgattgggtt gatgaatatg atatgtatgg tggccaagcc cttcacattg
     6301 attttgacaa gtatcaaaaa acgttagcta aattaggact gcgctaaaat atggtataat
     6361 ggagagtaac taaagttgct cttcttttta tgagcaatga ttagccctag aaaaggaaaa
     6421 agaataagaa tgttgacaaa aaatgatatt atccaagttg aaatttcaga tttaagccat
     6481 gaaggagtag gtgtagctaa acacgatggc cttgttttct ttgtggacaa tgccttgccc
     6541 ggagaagtga ttgacatgcg tgtcttaaag attaataaaa acaggggctt tggcaaagta
     6601 gaagcctatc atcgcctgtc atcagctaga aatagagatg tcaatttagc ttatttacga
     6661 acaggcattg cagaccttgg acatctggct tacgaagacc aactggtttt caagcagaaa
     6721 caagttcaag atagtctcta taaaattgct ggaatcagcg acgtggcgat tgaaagtacg
     6781 cttggtatgg cagaacctct agcttaccga aataaggctc aagtccctgt cagacgtgtt
     6841 aatggtcagt tagaaacagg atttttccgc aaacattccc atgagttagt acccatttca
     6901 gattactata ttcagaataa agacattgat tgtcttatta atttcgttcg agatctcttg
     6961 cgtcgctttg atgttaaacc gtataatgaa atagaacaaa caggtctctt aagaaatatt
     7021 gttgtccgcc gaggccatta ctctggagaa atgatgctag tattagtgac cacacgacca
     7081 aaagtattcc gtgttgacca agtcattgaa aaaattgttg aagccttccc agaagtggtg
     7141 tctattatcc aaaacattaa tgataagaat accaatgcta tctttggtaa agagttccgc
     7201 accctctatg gtagagatac cattaccgat accatgttag ggaatcgcta tgaaatttca
     7261 gcccaatctt tctatcaagt taatacagtt atggcagaaa agctttatca aacagccatt
     7321 gatttctcag aactatctaa agatgatgtg gtcatagacg cctactcagg tataggaacc
     7381 atcggcctat cgtttgctaa aacagttaaa gcagtttacg gtgttgaagt gattgaagca
     7441 gctgtccaag atgcccaaaa aaatgcagct ctgaatggca tcaccaatgc ccattttgtt
     7501 gcagataccg cagaaaatgc catggcaaca tgggctaaag atggcatcaa accagacctt
     7561 attcttatag atccgccacg aaaaggccta acagaaagct ttatccaagc cagtgtggct
     7621 atggcaccca ataaaattac ctatgtgtct tgtaacccag ccaccatggc gcgtgacatc
     7681 aaacgttatg aagaactagg ctaccagctc aaaaaggttc aaccagtaga tctgtttcca
     7741 caaacacatc acgtcgagtg tgttgctctg ctcgtaaaag cctagaaacc tttgaacgaa
     7801 agggatagta aaatgccttg atatcagggc ttttttgtta tgtaaaggga agtatcagag
     7861 tgagagttaa gattgaatga gtaggtttga tagtttgatg tttgagtgat ttatttccat
     7921 aaaccctagg gggtacggag ttatttccat atactagggg tcagtgggaa taaatgtccc
     7981 ccccacacac aaaaaaaaat aatctgttta taaaaaactt tttatctgga gaaatagcga
     8041 tgtattaagt tacagactta ctatgttaac atagaaaatt taggacaaaa atgaagttta
     8101 aatcgtacca atcttggtgc aatttttata tttttaatgt gttataatgt aacttaagaa
     8161 agcagatgct aaatttgcac cccctaaaga tgaaaaaagg tgatattgta tgataaaact
     8221 aattgcgaca gaaatcggaa taaggaaatt gatacaatag aatgcaaaga aagccttgga
     8281 aacagcatat tccaaggctt tttaactgtc tatgggtaca agggaaaagt tgctagagca
     8341 gggatttttt attgagacac ccttgatcga tatgtcgtta aattttagaa taacatttca
     8401 cttattcttt gttgactagt ttatcgaaat ggtcagtata gtgtaatttt aacttgtctt
     8461 ctcctaaaat atcaagtact tgtatggctt gtttcatctt ttcaattcca gtgcctgatt
     8521 ggcgcttaaa ttcaaagtaa ccagttgcat atagaaaaac tgtctgttca taaaagttta
     8581 attcattatc taacaacgcc tttatctcat caattaaata ggagcaatta gaaaattttt
     8641 ccttatcgat gctaagaatt aagcaattga tagcgagctg agtgacaata cgcttattgg
     8701 ttttattcag agatgagtaa atgtaattat ttaacatttc tttggttaat aagaagtagg
     8761 agttgtagtt aattgtacgt acacagttac ctaataaaat gatttcatag tagccccatt
     8821 tttcgacttt gaaaagatag tcggtcagtt gaagtaactc ttcatctgat ggaatgacgt
     8881 tcgaatccat tgtgtgtaaa atggatttta ccatcgtttt ctccaaagaa tttaaagtgt
     8941 aattagaagt gtcgtaaagt agacatgcta tattattgat actttgtgat gaatattgct
     9001 tacgaatgta ctgtaccagg ttagcaaatg attcgccatt ggtatagtct tcattatgta
     9061 aaataaggaa ctcctccaaa gtaatatgta atttgtccaa aatattgatt agtcgaatac
     9121 aagatatctc tgactctcca cgttcaaaac gagatatttg tgattttgaa agatgttcat
     9181 ctgctacaga gcatagacta atttgttttc ctttacgaac ttttttaagt gtgatgccaa
     9241 gttttgattt cataattttt cccattttcc caacaaaaat taactcagtt tttatttatt
     9301 gtacaataaa taaaaactga aaggaagtct gagtatgaag aaaatttcaa aacttgtccc
     9361 aattttggta ttggtaatgg acatcattat catcgttggt gggtaaatcg cttaggtgta
     9421 cacctaagtc tttagatact ctaaagactt agtaccacta tttgttcaaa cttttccata
     9481 aaaagttcat ttttagtgta gttattttct ctaaacaaat attgagaagg aggatctttt
     9541 taaatctgag ttttatatat ttctctatta aaaaatataa aaaaattgaa aggagtttgt
     9601 catggataaa catagcgagg ttactcttga aaatgaaatt ctttttcaag agtttgatga
     9661 agatgttttc ggtgcttgta cgactaatac tttttccttg agtgattatt ggggaaataa
     9721 aggaaattgg tgtactttga cacatgaatg tatgaattgg tgtaaataaa gaaggagaat
     9781 ataatggaac aaaataattt agaacttggt aaatatttag aatcagattt attgtctcta
     9841 actgacgaaa atgttgatgg cggtacaact ccggcgagtc cagcgactcc atatactcca
     9901 gcgattggta agggtgtcat tgcagtaact gcgtttgttt cagcaaacac ttgtccgact
     9961 tcagcttgta caagagcctg ctgataatta ggagaaaatt atggtaggat atgacaagga
    10021 tatttatcca gaactaaaat ctgaatctga atttaatgag tatatttcac ctattattga
    10081 aggtattaaa catcttacaa taacaggtga aatagtaagt cagagtaaaa atgattttat
    10141 aaatattgaa gagacttatc catatcataa ttcttgttta ttctttgttg ataatatttg
    10201 gaagaaactt tggaatgata aattaaataa tctcttattt gattctgaag acttcaagga
    10261 agctatctgt gaatcattgg cacaggtagc ttttacttat tttattagat gttttgctaa
    10321 tcaaataaaa gaatattcaa ctaatacaga tataaaaaag aattataagg agtatagtcg
    10381 atttcttatt gataactgtt ttaaaaattt ttcatcagaa tatccagtta tctggtatag
    10441 atgtaataaa ttagttatta acaaagttaa ttatatcatt attgtattaa atactctcac
    10501 aaaatcaaga gataaaattc aaaataaatt taaaatttca aagcaattga gagtaaaaaa
    10561 tattcttatg gatggtgata gtcataattg tggtaagaca gtttcgacaa tcatatttga
    10621 aaatggagaa aaattaattt ttaaaccaag aactgttgat ggagagtatg gatatgctaa
    10681 attagttaat gaattaaata tggcttttaa aactaatttt ttagccgtag ataccttgaa
    10741 agtcggtaaa tatggttttt gttcattcgt tgaaattgat gattctagta ttgacatggt
    10801 aaaagctgga aagttagcat gtcttttgta tttattaaat gctacagata tgcactattc
    10861 gaatatttat tggacaaaag aaggaccgat tcctatagat ctagaaactt tatttcatgt
    10921 tccaagatta aagaaaggtc tcgaagagtc acaaaaaagt gcttataaat atattgaaca
    10981 atctgtttat agtacaggag tactaccaat taacttagtc agtaaaaatg gaacggtaga
    11041 tgttggtttt actggtgtta ggaacagtaa ctcaattggc ccaattaaat cgattgaact
    11101 actagacggg tttacgtcca atattcgatt tatttgggga aaatatccat ctactacaaa
    11161 catgaaaaat aatatttcag agaatctaca gatttttcag aattgcgatg aagtttctaa
    11221 gggctttagt gagatgtatg aattggtttt taataataag gaatggtttt taaatacggt
    11281 atctaaaatt ttcagtaatt ctaaggtgag atatattcac aatatgactt atcgttatga
    11341 acaaatttta agaacattaa catctactaa agcttccaag tctgaatcac tttcaaaatc
    11401 aatactctct agactaggag tgttaagttt aacatgtgag aaaccaatta tcatttcgga
    11461 gtgtcaacaa atttggaatg gagatgtccc ctattttact gctaattatt ctgaaaatta
    11521 tatttatgat tatgatgaaa aaattatagc acgcacaaat tctagtccaa agagtaattt
    11581 tgaagataag ataaaatcat tgtcaattaa ggatttaaat gaacagctta agataataaa
    11641 actagctttt gttgccaaag tacaggatcc tcatggtgaa aatgccgaag catttaaact
    11701 gaaaaattcc ttgaaaacaa gtaatgaaat tattaaatta ttatcggata aattaatgaa
    11761 ttcagtctac gatgataaat atgaacattt gccaaaaact tggattggtc ctgtatccac
    11821 gcatacaacg aatggttggg ctccaggtgt tttaggatat gatatgtatg gtggtcgaac
    11881 aggtattgct ctcgttttag cattggctgg tacaaaactt ggtgaaacaa gatattctga
    11941 tttagcattt caaatcttcg aagcatatgc aaaaatatta gaatctaacg tatatgaaac
    12001 aagaagtata ctttcttcag gaattggttt atattctggt tttccaagtg taatttgggg
    12061 gctttatgaa gcaagtcata tttttaaaga agagaaatgg aagaaaatag caatagattc
    12121 ttggaaaata atagatgaag aaatttgttc tgtaaaatca ggtttctttg atatgatgtc
    12181 gggaaatagt gcaacaatta ttatgcggct aaagatggat aaagagtttc aattaaataa
    12241 ttatcagatt gaacttttta tttcagaagc tttaaaagtt ttagaaaata gaaacgagag
    12301 gaccacttca ggattagtcc atggtatttc tcatcttatt tggtttttta gtattattta
    12361 tcaaacctac ccaacagcag ctgtgcgtga gcttattaat gattgtttaa aaatattaaa
    12421 agagaactat tattctgaaa aggaagagat aaatatttat gaacggacgg attatcaatc
    12481 agattcatgg tgtaatggtg tttcaggggt cttactagca tattatgaag gatttaaagc
    12541 tggtatagta gataaaaaag atgttagttt gcttttacaa caattaaaaa gattacgaat
    12601 aacaactcta cctgtgtatt gccatggaat actaggaatt ttagaagttc taaattatat
    12661 gaaatcagac tttttagaag atgttagttc aattttattt atggcagact ttaaaggaga
    12721 ttttagtaat gtaatatatc attattttaa aagcgagaaa ggtaggtata cattgagtcc
    12781 gggtttcatg tccggaattt ctggagctgt ttattatttg tgtaagttaa atattgattt
    12841 taaaatttca cctatcactt tggagaaaca ctatgaggat gagaaaaaaa ctaattccaa
    12901 cactgcaaat tgcacaaact gagtgcggtc tgtgttgtgt taggactata cttgagtatt
    12961 atggttttga tatatcaatt acggaattaa gacaaattga agaacctgga agagatggac
    13021 taagtactaa gcatttaaaa aaattgttgc aaaaatttaa tttaacatca aatacatata
    13081 aaattaataa tccaaacgcc ttcaaagtaa tagacttccc tgtgattgcc ttttggaaag
    13141 gatatcattt tgtatgtata gagaaaatag agaataatca tgcatttatc atggatccct
    13201 caattgggcg tgtaaaaatt gatttaaaag atttttttga aaacttttcg gaaattatta
    13261 ttgcatctta tccaaatgaa acttttagaa aaagaaaaaa aagttttgct aaaagatata
    13321 attacagaaa attaattcct tctgatattt taaataatta tttgggatta ataattactt
    13381 ccgttctagt aatagctatt aatatttcta taccagtttt gactcaatta ctcattgatt
    13441 cagtccaaac aaataattac gattttcgat atataatttt aagtattgta tttctaggta
    13501 ttgtatcggg tactgtattt tactttaaat ctgttttgtc aattactttg atgaagaatt
    13561 tcagttggca tttattaagt acagctttca atagaatttt atctttgcct tcaaaatatt
    13621 ttactgtaag aagtccggga gaaattgtct atagattaaa ttcattaact agaattcaag
    13681 atttatttgg aacatcattg atccaattat ttttggacat cattagcttg tttgcaattt
    13741 taatttattt atctggcgtg tcaattattt taactggagt tgagttgctt tttatattgt
    13801 tgctttttac attattaatt aacttacagc ctaaaattca atcaacaagt gataatgaac
    13861 ttcaccaggc ttcattagcc caaagtatac aactagatgc aattgtgtcc attaacaata
    13921 tcaagctagg aggatataag gaagcttata aggaagattg ggcaagcaag tataaaaaat
    13981 ctttggacta cacagccgaa agaatgaata ttcaacaatc ttggataggc accattttag
    14041 ggatggtgag tgcctttgtc ccacttgtta tattgtcgat ggctttgttt caattttctt
    14101 tggggcgact gagtttaggc gaggccattg cgacacagac ggttacatca ctactttata
    14161 attacgccaa ttcaattttt actactttct caaatttttc tgtattaaat cgttatgtag
    14221 atttagcaga agacatatat gaatatccta ttgaaaattc tggagatata aaatatcaaa
    14281 tttttaaaga cgagcttgtt ttagataatg taagctttag ttatagcggg aataatatat
    14341 atgctttaag gagtattaac ttgaaaataa aaaaaggaga aactatcgcc ttagttggag
    14401 aatccggttc cgggaaatct actttaggca aaataatcag tagtctattt atgcctacca
    14461 taggaacaat ttatcttgac ggtatttcat ataaggatta tgaattagat agttttagaa
    14521 ataggatagg atatattccc caagaatcat atcttcataa cagaagtata atagataata
    14581 ttgccttagg ttgtgaaact gagcgcgatg aaataattaa aaaatgtaaa aatattcctt
    14641 ttttagattt cataaataat ttaccaatgg gatataatac tcaaatttct gagatggggg
    14701 ggaatttgtc cggcgggcaa agacaacgta tacagattgc gaaaatttta ataaagcagc
    14761 cagaattatt aataatggat gaagcaacat cctcgctaga caatgtttca caaaagtatg
    14821 tttacgatga gttaaatgta atgaactgta caaaaataat tatagctcat agattagaaa
    14881 ccattttaaa tgcagataaa attattgtat tagagtctgg aaaaatatct caagttggta
    14941 ctcatgatca attaattact gaggccggag gattgtattc aaaattattt acagcagaga
    15001 atttggagaa taaaaaatga tatcagaaag ttcaaaagtt atcgaatcag tgataaatta
    15061 ttttgagagt gatattaata aggcaaagga attgttaata tcaaaaatta atcaatcaaa
    15121 tggtggtgat aaaattattg aaaactttat tgatgtttta tatgatttaa tcgctaaaca
    15181 agcttggaga ataataaata aaacgtttgt ttatgagttt catgaattta gaaaacaaaa
    15241 aggtttacca atttctaaaa cgtcatcatt ggcatatgag atgtttttat cagaaatgaa
    15301 taaagatgta attggaaaat ggttaaaaaa atatactgtt cttcatggaa tcttgcaaga
    15361 ctcaattcta aattcttgta aatttattac agaagtattt tattattatg ctgaagataa
    15421 atctctttta atagatagag ggtttttagg caaggacgct cagataaaca agataacttt
    15481 attagattca gatccacaca ataatggcaa aattgttctc ctttttgagg atacggattg
    15541 tcgaaagttt atttttaaaa atagagattt taaaattgat aatcttataa atgatatttt
    15601 taaaacactg tttttaaacg cccaaaaaaa catggagtct ccgattcctc aaaatataat
    15661 aagagatggg tatgggtggc agaaatttgt agaacaagta ccagtcctac gtgcaaatgt
    15721 aggtgtatca ttttataatc tgggctacta tagtgtatta ttttcggttt tgggtgccag
    15781 tgacttgcat gatgaaaatt taatttttag aggagaagtt ccatacttta ttgatttaga
    15841 aactgcactt cacccacgat taaatagtac agagcaaagt ttaattggag aattacaaaa
    15901 cagtattaca aaatcaattg cgcacacaac aattatacct tcgaaattat tgaataattc
    15961 atataattac ttgattggag ctataaacac tccatatccc caagaaaccg aaaaaatggt
    16021 attttcattt aaaaatttgg gcacagatgc aattgatatt gcaaaagaga aggtagtatt
    16081 agatcgttta gcaacgcctt taagttgtac tgatggaaaa attatagatc ctgtaaatta
    16141 ttatgatgat ttcctttcag gatataagag tggttttata gacataatga acaataaaac
    16201 tatgatttct aagaaagtcg aatcatttaa aggggatata agagtagtgt taagacctac
    16261 tgctcaatac tttttaatta tggatgcatg tttatatccg gaaaacttga ttgattattc
    16321 ttctgcgaaa aagatattgc attatctaaa gccaatttct tttattaaag acaagacaat
    16381 agcgaaaatg atttatgatg aagaatgtaa atctttactt caaggagata taccatattt
    16441 taaagttgaa tctgatagct taaatttagt tattaatagt aatacttaca aaagagtcta
    16501 ctcagtttca gcaattacca atgctctgga aaatctaaag tgcctcagtg actcacagct
    16561 tttatttgat tatcgtctaa tttcagaagg tttttcagaa atcaaaatta gaaattctaa
    16621 gaagggtaat gtaaatcgtg acaattctaa aatgtatata gatttactta gggatttaaa
    16681 aaatggaaac tttgaaaaaa tattagactg gtggaaagct caatccgttc tctatgaaat
    16741 gaataacaca aaatatcgag cgtggcacaa cggttcttat ggtgaattac cttccctata
    16801 tagtactccc actttgatat ctttccatga tataggtggt gttgaaatta tgttagaaag
    16861 cctgttatta gctaaaggca cctcgaatag tagagttatt tttgaagagg ctcgaaacgg
    16921 tttaataaag ttaagagatg aggtatatgc tggtggtagt ggtgattacc attcaattat
    16981 tgctggagaa gaatccgtag attttatact ttctaaaagt gataagcaag taaggaattt
    17041 ggaattaaaa gtaaaaaata gtgagattcc aatcggagat gtattcaatg gtaaattagg
    17101 aatatattta gttttagcaa gttattcaag aacatgcttg gatacaatgg tacaaggaga
    17161 gattgaatta gcaaattcat ctagcgacta ctcgaaattc ggtttggccc atggtaaatt
    17221 aggtgagtta tggacaaaat ttagaattta tgcaaagtta gatcttaaca aagagtgtat
    17281 gaggatatat agcgaaactc ttaaatgtta taagaacgga aaaatattac caggttggtg
    17341 taatggttat tcaggtctct taatggtttt ggtagaaatg tcaaaagtac taaatataaa
    17401 aattgattat ttcgaacttg cattaaaatg tgttgactta cctgaaaatg cgtcaattga
    17461 tttatcagtt tgccatggaa caagcggagt catacaaagt ttattgtttt gttatattgt
    17521 aacaaaggat aaaagatata ttgaactagc tgatagttat tggaatctag tttataaaaa
    17581 agcgcagagt gacggttttt atattggaga aagtaacaga gagtacctat taggttatat
    17641 gatggggtgg agtggtgtga ttgacacgat attattacta aacttattaa aagatggaag
    17701 acagcattgg attcctttaa atctaagtac tattgactat caggaacaat tgaaaaagga
    17761 gacattcaat gttatcggtt gtagcgttaa atccaaagca tgatataatt aacaaggctt
    17821 ttaatgtcgt atacattaat ttcgggaata tccagattcc atttggctta atagagtttg
    17881 aacagccagt atttgattta aatgatccca aaaatgacga ttatttattg ataaaagtta
    17941 actcattttc gtgtaattat cgagacaaag ctatattggt aaataacttt gaacaattgc
    18001 ttcgtttagg aaagccattc cttcctttcg gatctgagtt tagcgctact attgtattaa
    18061 aagggaaaaa tgtagatgag tttggcattg gtgataaagt aattcctaac tgtacttatg
    18121 aaggggttac taatgataat gttgttccag gtgtgacaac taattttgca tcattaggct
    18181 ggttgagaat taggagggag aagcttatta aacagcctca tgagttgtcc gatttagaag
    18241 cagcttgctt tagtttaggt gcacagactg cctacagtat gattaggaag tctggaatat
    18301 tggaaaaaca gaataaaaaa gcagtagtat ttagttcaag atcagttact tctctattta
    18361 taattcaact tttaaattat tttggaatag atttagtatg ttgttctagt agtgaatgga
    18421 gtaaagaaga gttagatagt attgggataa aaaaagtagt aagtgttgat ggaattgaag
    18481 aatatctcga ttcattctcg catgtatttg atccgtattt tgatttaaat ttcagtagag
    18541 ctgtaagcct tttaggtaat ggagggaagt acgttttttg tggctttctg aatcaacatc
    18601 ctgttttatc aaaagaagat gataaaacat tgaatacaga agaaatattc aattcgttaa
    18661 aattagttat tgtaaaaaat atctctctaa ttggaaattg tttaggaagc caagaagact
    18721 taaataaagt aattgaaatc tatggttctg aaatttcgcc gactattgat tcagaatata
    18781 atttaggtca attggaagag ttcttgacaa gaagtttttt tgataaaaat aaatttggga
    18841 aatgtgtaat cgattatagt agggaaggtg ttacatatgt ttaatagatt tttgagtata
    18901 ataatttgta tcattgttgg gaatatcgta ttgacaatat tggaaagttt gggtatgaat
    18961 gtttggattg caagactaat tgcttgtata gttgtcggaa tatgcggtgt tctaatttac
    19021 cgttttgaaa aaaagtaaag ggaagattct atggaattat ataatgttgt taaaaaattt
    19081 aagaatcatg tcgtattgaa tgatatttct tttgagataa ataaaggaga gattgttggt
    19141 ttagttggaa agaacggtgc cggaaagagt acgctgatga agattatttc aaagttagat
    19201 actaatttcg aaggaaaaat agatgaagta ggtcgcttgg ggtacttcat tgaatcgccc
    19261 aaattagtca ccaataggac tggattgtgg aatttaaaat atttttcgta tatttttggg
    19321 aataaattct taattgaaga ttattttgat ttttatcaat ctatagaaat aatagatttc
    19381 cttaaacaga aagtaaaaaa atattctttg ggaatgaaac agaagttagg agttctaata
    19441 gcattattaa acaatccaga ttatgttata ttagatgaac ctacaaatgg tatggatatt
    19501 gattctagta ttgtcttttt acaagaatta aaaaaaattg taaaggagaa gaatataggg
    19561 gtttttattt ctagtcacaa attagaagat atagaactga tatgtgatag aattatattc
    19621 ttgaataatg ggaaattaga aaaattaaat agtagggagt ataaaaatag gattatacat
    19681 aaattgatat ttagagataa aaatgatgtt gatttatttc taaaaaatca aaacataggg
    19741 ataataactg aaagtcaaga tgattttatt aaaattgaaa caagctgctc atatagtgaa
    19801 ttaatggact taattaataa attgaatatt agtttgttag attactccta tgaacaaaaa
    19861 actttacgag atatctacat agacaaaatt atcaaggggg attgatatta tgaaattcaa
    19921 caaacgatta tatattaaaa attgtcttaa agaattaata acctctggta ttataataat
    19981 tggagtaatt gttgccgtaa ttccacctgt aattttaatg tattatatta taaattatgg
    20041 aagtaattcc ttctacatca aacatatttc aaattttttc tgcatttttg gactatatat
    20101 tggtgtttta agcccacttt attttataaa tagagatttt tcaatggata ctattgcatt
    20161 agtttgtaat actaaagaaa atagaatcgc ttatttaaat gccaatgtat tacttgcttt
    20221 ctttctctct ttattttact catctattgg ggtagctaca gtactgatag caaattatct
    20281 cggtgttacg ggtgatttga ccgttaattt cataattgga ttcttttgta atttaactat
    20341 tacgataatt ttctattatt tatttagcta cctattattt tcttttttta taaaatctaa
    20401 tgttgttttt tcatttctaa ctttattact attgtttatt ccgaatataa tttcgaatat
    20461 tttatactct acgcaaaacg aattgttaaa taatttattt gaaaaaattc caatgtattt
    20521 tttgccaatt tatgcaggtt caaatatcat ggaggttagt caatatataa tttctatttt
    20581 gagtatttgt attttatata cactatctat gaagaaaact ttaaatctta gattttaatt
    20641 tatacccgtg gtgcttaagt gaatttgtca acaaacattt atcaagtaaa cgtttaatga
    20701 tctttttagc attatatagc ttgatgttaa tgctagctac accactttat tttatgttcc
    20761 ataatgtaat tattcgaact ttttctcggt gatattaaat cctaacaata cacttaatct
    20821 ttttattatt ggtgcgtcta ttactgtatt atcgttagta tttggaacac tatttaaaag
    20881 gtataatata ggttaataga tattacttga taatattaag taaatattcg accttaaaag
    20941 aggataaaca gcacagaatc aataatttat ctaaaacaga ttattgattc tgtgctgttt
    21001 gatagctaac tattactatt tactatttac aatttctata atgtcctcaa tcttgcaatc
    21061 aagtgcaata caaattttca ataaaatatc ggtcgtgaca ttctctcctt ttcctagctt
    21121 tgcgatggtg gaagaactga ttcctgcttt ttggcgaagt tctgatttag tccatccttt
    21181 atcaattaac aacttccata atttattgta gctaaacttc atctgagttt tctcctttat
    21241 tccatgaaat accgtagagt tcatttccgt tgctagagag tctcaacaca gtattttctg
    21301 acaagagttg attagcttct ggagaataag agctagcttt atcaaaggct aaaaagactt
    21361 gtttgttcaa tgactttgat tgatcataca gcttcaaaag tgcctcagtc gcctggtagc
    21421 taatattact caagagtaat gagtcgtgtg caagtgctgg caggttggtg agatagagca
    21481 tggttaggtc aaataaaatc atccctttga acttagttcc tgtaccatca tcatctggtg
    21541 tatagaagga gtagctattg tgagctttga ggttaatttg cggagctttg cgaatatctg
    21601 gatacagaat gttattgaat tcatgcatct tgctattgat ttttacttct aaatccagaa
    21661 ggatatcttc tgtactgcgt ttcaagtcag cgtcggcttc agatttttct ttggatagac
    21721 tagattcctt taagtaggcc tcattttgtt ctttcagtgc attgattgta gctgttagtt
    21781 tagagtagtt ttctaagtac tcacttgaaa gatttgggat atttcctagt tcttgaagtt
    21841 cttggtttag aattgttaat tgactctcta attcgtcgat ttcagctatt agggattcac
    21901 gttcgattga gaattcggaa tctaaaatat tggccaattt tttatgatag gcttcaactt
    21961 catataattt tttgagatta gtatctggga agtattgttg aagctctgtt aagtcagatt
    22021 cagttggata taagccaaat tcgatactga tgtccaatag cttaaggcgt ctttgcttat
    22081 ctctaagact gttctctagc tccagcttag tatttctaag ttggattttt tgttgatttt
    22141 tctcaatatc accagagtca attttatctt gctgagtatc ttggagatgt gataaatcat
    22201 attccaaact ttttatttct gagacattcg cttcaaattg ctttttaccg ccaaccaggt
    22261 tggagatgaa ggcatacttt cgagcattac ggaatgttgt gagctggtcg ctcttatcct
    22321 ttaaccgttc tttgtatcgt gcaatgttat catacagatt aaaaagctgg ataagagtga
    22381 taatagattc tgaagatttt tggctcgaat aaacttgtag agggaaatca gtattttgat
    22441 tactttttcc tgcaattcta aagaatccac tcatagctaa tcgaaatgat agatttggag
    22501 aatctaaatg atatcgcttc ttaagtttgt tcagaaagat ttctaggggc attgtttcac
    22561 cagtaggaga ataatcatcg ttacaatatg taatgatgtc tggatttgct gtatctcttg
    22621 agaaataaaa ctttttctca aattgaaagc agaagtagat aggatggtca cctaatttct
    22681 taacagcgat agatttttga taactattgc ctccaaagat gaaatcaatg gctaatagtg
    22741 aggaggattt tccgatagag ttatcagcta aatccatccc cataatcaca tttaatccag
    22801 gatgaaatcg aactggtttc cgagtttgcc cattcttctt aaagacgggc gaccacattt
    22861 ctataagcat aattttacct ctccttcatt agacatttca atggcgttca atgcatacaa
    22921 gcaatccatt atggatagga aatctgtagg atcatccaac tcttctgaga tagcgtgaaa
    22981 gatatccttg acgtttgagt ttccactttt gatttcattt agcactctag gcaaataagc
    23041 tagggtgctt ttttggtagg aataaagttt atttggtaat tgcattattc aagaacctcg
    23101 catttttgga taaagtaaga gacaatcatc tggcagaagt agatgtcctg tagtgtagct
    23161 ttatggagtt tttctgaaat agtattgaaa atagtcagat tatcatgctt ggcagccttt
    23221 aactttttgt acatcgatcg catttgatat tggatttcct cgtaatcgat tcttccttgt
    23281 ttatctaaat ttataatgat tttttgaatg gttaagtagt tatcaataac ttggttttta
    23341 accatttgat aaagcatacg atttttctca ggtgatatct tatcagtcaa ttgcttcggg
    23401 tcataggaga tatcatattc atcaaatttt agtttattga gactagtcaa aactgaaaca
    23461 attccactgt ctaacttcat atcagaaatc gattgttggc tgttctttgc tgaaactaga
    23521 atttttttga tatttttaag cgatgctacc gtttttttac gattatctgt ttgataggtt
    23581 aaaaaacaat ctggacatag ggctattaag tttagcggct caggtacctt atctttttct
    23641 attacagaaa cctcatagct ttctgtggct aagttgcccc ttgttagaat gagtggtctg
    23701 tcacaacctg gaaaggcaca acagttattg gcttctgtca ataaaaattg tccgtattgt
    23761 tttttgagtt gattagattg ggttatgaat gaagctttct gcgctgtggt tgctgttccc
    23821 atcccagctt tctctctaat gaaatcaacg aaaatttctg gaattcttag tgaggcattt
    23881 ttagcagtaa tatcaggata ataagaatta aattcattgg ctagcaactg aatagtttca
    23941 tctggtctac tttcaataga gtccttcata ttaattgagt tgattttaca gatcagttga
    24001 tttgccatct tcttggtgaa gcctcttttg gcataggaaa ctagtgtact atctgttttt
    24061 tctgatgtaa tttcagaagc actgatgatt tcttctgcat catcttcagt aatcatttca
    24121 atgagttctc gaaaaaactc tggtatagtc gcgccatctc caagatattt tttcagaatt
    24181 ctaaaataag tgggaaaatc caagtgatgt tctccttttc atttttgtac caagttgtac
    24241 cgtactgtac taaactgtcc cttaattcaa aatctcattt aatacaatag agtcgaacaa
    24301 agtaatcgtt aatgattacc tttattatat catgacagga ttgcgatgtt caaaaatata
    24361 tttgcgaacg cataaaaaat tttgcgaatg taaaaaatct tgattatcga atagcgctaa
    24421 taggtaattt gagaccgttg ttgcctaatg atgatacttt gtaaatgagt gaaactgatt
    24481 taccgtgact ttaagggtac aaattaggtg tgcagttcag cttgtaaagt cagttgacca
    24541 tgaattagca gaggaattgc tgatgtggtc agaaaatctt tttaatagtt ctttgtcttg
    24601 tcacgtttct ctgcttaaga cagaaagtgg aaaacatgac aaacaaggac aatatttata
    24661 acgaatgtca aaaacaagaa tgctccctag aagtcggact tttagagggg caggtgctag
    24721 ctcctatgtt ggttgagaac caacaagtta ttgaggatat gcgtctcaaa agagagaccc
    24781 ttcggtcttg gaggccagct aaacagctga atgtttatgt actggttgct tttatcccag
    24841 tctttcctga agaatttgct aaaacggaac gtatctataa agatgccgtt gaaaactttt
    24901 tgaatgagtt ccgtacacgt aagtcaaaga atattgaaga gattatctca tatgaagcct
    24961 ggattgatat ggatgaatct actctttaca gttctactga agaattggaa gaatttatgt
    25021 ttgcagaaat gctacaagat ttacttgaga aagtaaaaca ggccgataag gatttgtatg
    25081 atatcacttt gggcttactc gccaaagagt ttgatgagag cattgaggat gtgtttatta
    25141 agattggggt gaaacgttct acaggtttct atcgtctgcc aaaggctcgt gctttagtgg
    25201 cggctttatt gaaagaatta aatcccaaat agggtatata tttgacacca gcgatgtttt
    25261 tggtataatt taagtagagg tagtcggaga gtagtaccga ctctaaaaag aaaatactca
    25321 ttcggagatt ccgcgcctta ctggaagttt taattttgga gattccgcgc cttactggaa
    25381 gttttaattt tggagattcc gcgccttact ggaaatttta aaagggttgt cgacgggcaa
    25441 ccctattttt ttaagtgagt gtaatatcaa ctatgcatga aatgaaattt tatcaaattg
    25501 atactaatta tctgaatata ctccgtcaaa ttgatggaag agttccgcat aataaagaat
    25561 ttattggtcg aaaaggaaaa tctagaccat atattggtgt gatgttgtct attgataatg
    25621 ttgattattt tgttcctttg agttctaaaa agaagcggtc ttcatttgta gttatgccga
    25681 tttacgatga taatgacgaa cagatagcga cattgatgtt aaataatatg ctgcctgtac
    25741 ctccaaaaca cagaaaatta ttgaatatgg atggtgtaag aataacagac ccgaagtatt
    25801 ttgatttgtt gatgaatgaa ttgaacttct tacgtcctag aagacaggct ataaaatcaa
    25861 gatgtaccat cattcgctct gttaaggttg aaggaaaaaa taagccgcag ataaataaga
    25921 aaacaaaaga attctgccta aatcttcttg agctagaaga ggcgtataag gaaaatgaat
    25981 aactaaaacg gttcattacc atatattggg tagtgaaccg ttttttgtgt ctagtctttc
    26041 tgatagaaga ggcattcata accatctgca cgaagagtga tgtcaggcat ccagttgggt
    26101 gcaatcccca tcaaggttga aatttcttca aggtcttggt cttgatcaca ctcaatgatg
    26161 acttcatcat ggacatgacc gacaatcttg aactcactaa gttgtctcat cgagtaggca
    26221 agaatatcac ggctaatggc ctggacaatg ttctcgacaa actttggtcc atagctttca
    26281 agtcgctccc aacgtttagc agttcctgta ccttcatagg tgacagactc tccaccaaat
    26341 tggttctcac ccatcttggg tttgacgtag gcaagttttc gaccagaagg gagagtgata
    26401 aataacatcc catttctgac ttcgaactga atgccgtgag tttcggtttg gatttgttct
    26461 ttgacggcag ttttcacagc cctatccaca tcccaccaaa aaaggacgat gctgggattg
    26521 gcttgtcgcc aggaatccac tagtggttgg agttcttgtt cctcaagtcc catatcaatg
    26581 gcgcccattg ctttaagagc accaactgct ccgccatagc cacaggccaa ctccgcaatc
    26641 ttcccttttt gacgtaggtc tgcattttga ccatgtttct caactggcac accgaacatt
    26701 tgtgacgcag acatacagta gatatcctta ccttgttcaa agaccttgct ccgccatgtc
    26761 tctcctgcaa gatgagacag aacacgcgcc tcgatggcag agaagtcaca cacaatgaac
    26821 ttcttaccct tacttggaat aaaagcagtg cggataagtt gtgacagggt atcttgcgta
    26881 tcgtagaaaa gttcagtagc ctctaagtcc ccagttttga agagttctct tgcttcttca
    26941 agatcaggaa gatggttctg tgggaggttc tgtagttgca ccaatctacc agcccagcga
    27001 ccagttcggt tagctccgta gaattggaac attcctctag cacgtccatc cttacaaacg
    27061 cagttcatca tggcttgata tttagaaaca ctggatttgg cggcttgctg ccgaagtttg
    27121 agaacttgtg cagttttctc atcaaccgtt ttgaggagtt ctttcacagc ttttttgtcc
    27181 agtgaatcgg tggtcactcc gtgttctctt aaccaaccaa tcatctgaag aacggagttg
    27241 ggattatcaa gttcagttag ttctctcaat tcctcttgga ttttagcttt actttcctcg
    27301 tcaatggtaa tcgcaccttt aacgaaatct acatcaatcc caatcccacg gtcgttgatg
    27361 atttggtctt gatggtattc ctcccaaaca aagactggaa cagggtagtt acggagtttc
    27421 tctttgatgg ctaactctac ctcaacgtca cgcttattgt aatcaatgaa agcagaccac
    27481 ttgtcgggcg cgtgattggg gaagtttcgt gttcgtccac cgttaacctt ggttggttta
    27541 caaggaaggc agaagtaacg aattaaatct ccgccttcct ttaacttttg gtttttgagc
    27601 ttgaggacag ttccgactcc ttcaagtgag agtggcagac caagatatgc tgaccaaacc
    27661 atactgcatc gccatgagtt tggagatagg aaaccttcgg atagtaattc tgggtgatgt
    27721 ttcttgagcc agttagacag acagatgcgt tcaaagctgg cattaaatgc ccacttgatg
    27781 atagtgtcat ctaccaatgc ttg
//
