LOCUS       NZ_CP047020            25445 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces broussonetiae strain T44 chromosome.
ACCESSION   NZ_CP047020
VERSION     NZ_CP047020.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces broussonetiae
  ORGANISM  Streptomyces broussonetiae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9735779)
  AUTHORS   Mo,P.
  TITLE     Streptomyces sp. strain T44 isolated from rhizosphere soil of
            Broussonetia papyrifera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9735779)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2019) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-OCT-2019
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 12.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009796285.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 17:56:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,022
            CDSs (total)                      :: 8,931
            Genes (coding)                    :: 8,515
            CDSs (with protein)               :: 8,515
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 416
            CDSs (without protein)            :: 416
            Pseudo Genes (ambiguous residues) :: 0 of 416
            Pseudo Genes (frameshifted)       :: 171 of 416
            Pseudo Genes (incomplete)         :: 334 of 416
            Pseudo Genes (internal stop)      :: 29 of 416
            Pseudo Genes (multiple problems)  :: 110 of 416
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:31:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8933844
            Orig. end                         :: 8959289
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047020.1.
            Bacteria and source DNA available from Zhao YL.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25445
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="33"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25445
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25445
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15445](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15445
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(<828..1280)
                     /locus_tag="GQF42_RS47855"
                     /old_locus_tag="GQF42_40645"
                     /pseudo=""
     CDS             complement(<828..1280)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016107.5"
                     /locus_tag="GQF42_RS47855"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40645"
                     /product="methyltransferase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MALPSLFSVLGIMCWIGYEILLRRREDSAAVTWQADDRDRGSTRL
                     LIVSYVAAAVINTVLGSTSVGQLPIAVRWFGVAALAGGLTLRAWGMHTLAQYYTRTLRT
                     VDDQRVVQEGPYRLIRHPGYCGSLLVWAGYSLGLGSRPATLIVAALL"
     misc_feature    1357..1371
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 20.79"
                     /tool="antismash"
     gene            1790..2245
                     /locus_tag="GQF42_RS40655"
                     /old_locus_tag="GQF42_40650"
     CDS             1790..2245
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151804.1"
                     /locus_tag="GQF42_RS40655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40650"
                     /product="hypothetical protein"
                     /protein_id="WP_158928445.1"
                     /transl_table=11
                     /translation="MTEGVDAGQANGAEEAGVGAAPILFRAELFTLTGDSDNKDPDTGT
                     HLTVKTGDEKALPASINNADSSGMDMTTYEDDSHHIVPLAVEAPGARKSDCDGFKVRMW
                     IKTKGSDNWPVDDARVTLCFSDGTTLVAEKLGFSLNGDGATAEFASL"
     gene            2380..2559
                     /locus_tag="GQF42_RS40660"
                     /old_locus_tag="GQF42_40655"
     CDS             2380..2559
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141534.1"
                     /locus_tag="GQF42_RS40660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40655"
                     /product="nitronate monooxygenase"
                     /protein_id="WP_199272970.1"
                     /transl_table=11
                     /translation="MGLSTVFAHLSGVEHPVAPAPMGGWAGGALAGAVSRGGGLGLVGG
                     GTGDLAGSDASCRS"
     gene            complement(3264..3989)
                     /locus_tag="GQF42_RS40665"
                     /old_locus_tag="GQF42_40660"
     CDS             complement(3264..3989)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389531.1"
                     /locus_tag="GQF42_RS40665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40660"
                     /product="hypothetical protein"
                     /protein_id="WP_158928447.1"
                     /transl_table=11
                     /translation="MSENTTPVTQLTSQYVNQVTGDLERNVKEQDRITAEISALQEQLA
                     GLQHDHTVLVSMQQALGVAAPAGTPAVTEGAVVPAPRKTPTVLTSTQQPPKKAAEQEAE
                     SRKSPARKPATKRADAKTSDAEKSDAKKSVAKKSVAKKAAPQAGQPTLVELVRRHLAEQ
                     KEPRSAAEVSEALGKAHPAREIQTKVIRTTLENLVARNNAQRTKQGTSVFYTVPSASAE
                     STPAPGAARKEESGPDAAQ"
     gene            4278..4931
                     /locus_tag="GQF42_RS40670"
                     /old_locus_tag="GQF42_40665"
                     /pseudo=""
     CDS             4278..4931
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158226.1"
                     /locus_tag="GQF42_RS40670"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="GQF42_40665"
                     /product="alpha/beta fold hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGTPTSYDGTGLAYRASGDGTPTVCPPGGPRPSATSVTWADCPRT
                     AH"
     gene            4942..5406
                     /locus_tag="GQF42_RS40675"
                     /old_locus_tag="GQF42_40670"
     CDS             4942..5406
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557810.1"
                     /locus_tag="GQF42_RS40675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40670"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_158928449.1"
                     /transl_table=11
                     /translation="MADWGIRQASAADVEAVAALRAVVLRADLERLGRYDEHRVRQRLR
                     DGFVPEHTWVIETAGALAGCVALRAAPEAHWLEHFYLHPALQRRGIGSAVLRMLTARCD
                     RERVRIRLNVLRGSQARWLYERHGFTVESEDPVDVFMVREPAAGGQGVSA"
     gene            complement(5388..6032)
                     /locus_tag="GQF42_RS40680"
                     /old_locus_tag="GQF42_40675"
     CDS             complement(5388..6032)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016207.5"
                     /locus_tag="GQF42_RS40680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40675"
                     /product="FMN-binding negative transcriptional regulator"
                     /protein_id="WP_158928451.1"
                     /transl_table=11
                     /translation="MYVPKPFTPDEADVRALLTHLGAADLVTMTPQGLLATLLPFEYDP
                     DTGEHGALIGHMARANGHWREPVQGEAMVIVHGPQAYVSPTWYATKAEHHRVVPTWNYV
                     RAHVYGRLAVHDDPAWIVAQMRRLTDRHEAGSAEPWSVDQAPAKFLEGQLRAVVGVELV
                     ISRIEAKAKLSQNQPRQNVEGVIAGLEARGRSDDAAVAAAVRAHSRYADTP"
     gene            complement(6048..7040)
                     /locus_tag="GQF42_RS40685"
                     /old_locus_tag="GQF42_40680"
     CDS             complement(6048..7040)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134380.1"
                     /locus_tag="GQF42_RS40685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40680"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_325100417.1"
                     /transl_table=11
                     /translation="MNGMKISELARRADVTTKAVRYYESLGLITPGRLANGYRDYDEDD
                     VRLVREIRALHRLGIPVERTRPFLECLAAGSAYADDCPASLATYREAVDELTERIEALT
                     ARRTTLIANLNAAARRGSAVVPPAAHGDGEDYLTLPADLPTPEDDGAADHLAGTAMPAL
                     TLLDTAGRAIRLDALGPRRTVVYVYPLTGRPGTDLPEGWNSIPGARGCTPETCGFRDHF
                     QDLLEAGAGRVYGLSSQDCGYQNEVVERLGLPFDMLSDPALGLAGNLGLPTFEADGMRL
                     FKRLTLVVRDGVIEHVFYPVFPPNAHAEQVLSWLRENPLRGGAATAHSD"
     misc_feature    7048..7063
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.3"
                     /tool="antismash"
     gene            7234..8298
                     /locus_tag="GQF42_RS40690"
                     /old_locus_tag="GQF42_40685"
     CDS             7234..8298
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012381033.1"
                     /locus_tag="GQF42_RS40690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40685"
                     /product="cobalamin-independent methionine synthase II
                     family protein"
                     /protein_id="WP_158928453.1"
                     /transl_table=11
                     /translation="MKIPTEPIGSLPRSPELLSAMAEFQLGRMDGAALKEIQERAVRDT
                     ITELEAAGSPVVTDGEQAKASFVTYPLAGSPGLSPDGVVIPFADGHQRRLPALTSGPFR
                     YKVSADQYLRAAQQHTRKPVKQAVVAPSMLSLLYPAAGISGYPREEFLHQLADESEAEI
                     RACLDGGAHVVQLDFDEARLCLKLDPGGRLLDDLVSLNNQVLARFTESERARIGVYSGP
                     GADQDSTHSLDVDYAELLPRLFWLTVGNFYLQLASESDPDRVLTLIADHLRPGVRVFVG
                     VTDPIDPRVETPDEVRDRVLRAARHIPVDQLGTCDDAGFAPFADDASTSRATAFAKIRA
                     RVEGTALAIEALGI"
     gene            complement(8965..9663)
                     /locus_tag="GQF42_RS40695"
                     /old_locus_tag="GQF42_40690"
     CDS             complement(8965..9663)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381706.1"
                     /locus_tag="GQF42_RS40695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40690"
                     /product="DUF2993 domain-containing protein"
                     /protein_id="WP_233273651.1"
                     /transl_table=11
                     /translation="MKFLAIAVVVPAVLFTVADRVSLHYADKEAERLAKEKYPYGNTTD
                     SHVDVSIEGFPFLTQVFSQDFGHVSLSAGQFTVDTTANAQGGCLHVKQFHLDLHDVKVT
                     SLSARSAEANIATGTLTLSYDELSDVVTRLAGSGGPLRVSQPPGSADQAAKLRITGTVA
                     GRPLDSTGTLLAQGTELGLTVPGAGQSAFTWRVPLPDGAGFTAARSTANGVEISMVGHQ
                     VTLGRSRFER"
     misc_feature    complement(9906..9920)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.88"
                     /tool="antismash"
     misc_feature    complement(9907..9920)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     misc_feature    complement(9908..9921)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.38"
                     /tool="antismash"
     gene            10001..10963
                     /locus_tag="GQF42_RS40700"
                     /old_locus_tag="GQF42_40695"
     CDS             10001..10963
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010475286.1"
                     /locus_tag="GQF42_RS40700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40695"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_158928457.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.5e-18, bitscore:
                     64.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEVERLLADCLQDARNISLGTVPVVSEEPAYTAVRRTFLTAGLS
                     ALRVNLPETNWVQVNLSPGPSAWQQTYRRIADTARALIAADLVGSFFFMHKPPGLRVRF
                     EARGAGHGLLRAELIRRFGDLDGQSAAPHCGTYEPETYLFGGPLSMRLVHELFTADSLA
                     WLDQHTTTPADGGPGPLADWRLSLVLLGELLDGLGVVGWEHRGVWEVVRDDTGRRLGTI
                     PDEDTRRAALGILDAWRAGPRALLAPLPDEQRSAVRAHAEAVRRCAERWRTGYFESGEA
                     IVGPRRAAAHYVIFHWNRGRLSLARQSLLTHALAGDGRF"
     misc_feature    complement(10023..10037)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     misc_feature    10027..10045
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.36"
                     /tool="antismash"
     gene            10965..13883
                     /locus_tag="GQF42_RS40705"
                     /old_locus_tag="GQF42_40700"
     CDS             10965..13883
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569786.1"
                     /locus_tag="GQF42_RS40705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40700"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_158928459.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.1e-11,
                     bitscore: 42.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQDPTLGGTALLRVAGMPLAAWTQAGSPDLFARLAEHTRDRERR
                     AERARALAERLGATVVPHPGLTAADRRAVLALRRRLHSGAAPGPAGCRLLERLPAARDL
                     TPEAVLLCAEAESAEKALREVERTVAAERARVGALGWALVCTSPVMRAFLQEAAPGVPA
                     DVVRRLAEGESWEGQRLRKRGAYLWRALGRAAAKTTPRGWAGQVVPLPVAPTAAHHGHG
                     SRLLPAGATLGALAAEAVENVHLLRGRLGALDLRASAPATLVAPAPLHFLDPAGDATQT
                     GTGVLRCWVIDQHQRGRMRQVVLRRTRPLDAVLAQLADGPRTLGDVEAALLGTAAIRAA
                     DPGPAVLRGFLAHLVELGVLQVCAAPRRRSTAWLPARQVLERNVLPRPAPTPAAQRGAA
                     LRAHDGDVVARHGGATGAAAPSGGRSAAVGSAPSPGRDRDAAAAARMPPPGHDHGADAP
                     VPRGDCAAAAHTGGSGAWFIDSYRTVSAAVPREAVDRVQRGLRIAARVARLQEADRIPA
                     TRTRAPAPELAALDERPRPLGEILARNLPDGSCPPPSPQTPRRYTGWHPAETTDSGYAL
                     LLAHLAAHTGEEQVDLDDELLDGLGAPPARTALPPWPLDCLLRPLPGPGPVAVLETASP
                     AGILDARFADALHTLFGGYANPTGYRAFLSGVERLTGARFVELLVPPLAERAANAVRRP
                     VVTEWWTGDPDPAPYQGPAGSSARYLALDRITLRRHGAQVIAEADGRRILPVHHATRSP
                     LPPYDVLVRLLMAAGHPAASRVMRLDGTIEALPGAERLPRVTVGGDLVVSPAVWRVPRT
                     RLWRPGDGDLAKARALGALRLGAGLPRFAFVRAVPRAKPVPVDFESLTALHQLERICAH
                     QPGPELVVEEMLPAPGQLLLRDPLHEGAAVAAQLLLRLPHEQSAGELAALAAAALRGAT
                     DVPGARPSAAGRHRGGAHPSRPLKEDSNARNHATQRPRRPHR"
     aSDomain        11832..12062
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GQF42_RS40705_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-13"
                     /identifier="RREFam001.1"
                     /label="GQF42_RS40705"
                     /locus_tag="GQF42_RS40705"
                     /protein_end="366"
                     /protein_start="289"
                     /score="42.4"
                     /tool="antismash"
                     /translation="VIDQHQRGRMRQVVLRRTRPLDAVLAQLADGPRTLGDVEAALLGT
                     AAIRAADPGPAVLRGFLAHLVELGVLQVCAAP"
     misc_feature    12816..12818
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13837..14007
                     /locus_tag="GQF42_RS45200"
     CDS             13837..14007
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016468357.1"
                     /locus_tag="GQF42_RS45200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_199272971.1"
                     /transl_table=11
                     /translation="MPEIMQLSDLDALIGDLETRITESTLPSAEADTGGCSGVCTVIVC
                     DTVVVCSGVVC"
     gene            14231..15445
                     /locus_tag="GQF42_RS40710"
                     /old_locus_tag="GQF42_40705"
     CDS             14231..15445
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019546723.1"
                     /locus_tag="GQF42_RS40710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40705"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_158928461.1"
                     /sec_met_domain="LANC_like (E-value: 1.7e-19, bitscore:
                     68.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQGTHHAEHTRSAVTALAGRLLDAWSARARDGAVAAEHPCDPGV
                     PALAALLHDVGEQAGAATAARAVAVWARSAGRGPGHPALYDGGLAGTLVGLRLGARLHP
                     QLHVAADRLRDRLVRIAPTRGPRRDGVTFADYDLIIGPCGTLLALCVDARPTPAQLEPF
                     AGHVAALCDAEDLPRLRTAGYAGHPHLDWLDGRVNTGMGHGVAGVVAALTATVRRLGPR
                     PDLTRALRHATRWLARQSFDDSRAIRTWDGAGLEGPPPTGPRARQAWCYGTPGVSWALW
                     DAADALGDQGAAAWAAGAFTTLAEHYDETFHLFGDRPADVLALCHGAAGVLAVADAFGR
                     HAGLPGADTLKARLLDHLLQRLPELHGLGEEAMGLLGGAAGSLCALLTAGQGASRTWLP
                     CLGLR"
     gene            complement(15410..>15661)
                     /locus_tag="GQF42_RS46435"
                     /old_locus_tag="GQF42_40710"
                     /pseudo=""
     CDS             complement(15410..>15661)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021514.5"
                     /locus_tag="GQF42_RS46435"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40710"
                     /product="ACT domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="FVLTVAEGDVPSDGTAVVTAAEQEGLTPVVPQAQADATGPAYGRS
                     ERAPPTSCGGRGRTPPEPHRPPESRRSSAQPETGQPRP"
     gene            complement(15787..16938)
                     /locus_tag="GQF42_RS40720"
                     /old_locus_tag="GQF42_40715"
     CDS             complement(15787..16938)
                     /EC_number="3.1.1.-"
                     /GO_function="GO:0052689 - carboxylic ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474316.1"
                     /locus_tag="GQF42_RS40720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40715"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_158928463.1"
                     /transl_table=11
                     /translation="MTQDIRDFLTPSCDLLALGEPTHQEPAFGRVRNELFAQLVECGFR
                     SVALETDRVAALAVNDYVQGGSGDLDAVMSEGFSHGWGALAPNRRLIAWMRAHNEHRSA
                     RERLTFHGFDAPTENYSAPSPRHCLEHARAYLGLDVDITGLAGDDERWSRTEAVMDPAM
                     SPGATPEAEQLRLIANDMLTSLDSRAPELIAATSRERWRRARTHLTAGLGLLRYHHQSA
                     TQPVDPGPRITALMATRDALMAQNLLDVRDIEAERGATLVFAHNVHLQGAPSTWRLGDV
                     SADWRGAGAIVAPLLGERYRFVAGSLGRSEALGLQDPGPDTYEGALQGRFPTWGLAAVA
                     TLSPARTRTDTTAQQGYFPLDQAALDTAHAVLHLADGTAAACP"
     misc_feature    16967..16982
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     gene            17039..17785
                     /locus_tag="GQF42_RS40725"
                     /old_locus_tag="GQF42_40720"
     CDS             17039..17785
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539037.1"
                     /locus_tag="GQF42_RS40725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40720"
                     /product="TioE family transcriptional regulator"
                     /protein_id="WP_199272972.1"
                     /transl_table=11
                     /translation="MRPTDLAVEHGISTQAVRNYERDGFLPPAERTPSGYRIYTEAHAA
                     ALRAFLALVPAYGHATAGRIMNALHRDALDDALTIIDRGHSRLLRDRDTLDAVRTAVGH
                     LTADSKAAPPPSREPGTRTVGELAHRLGVTPATVRSWEEAGILNPARDPATGYRLYDAA
                     DIRDAELAHLLRRGGHLLDHIAMVVRQIRTAGGTDALAASLDAWQRRLTAQGLAMLRAA
                     THLDTYLGLLDPTAPEPFTGHRPRPE"
     gene            complement(17794..18534)
                     /locus_tag="GQF42_RS40730"
                     /old_locus_tag="GQF42_40725"
     CDS             complement(17794..18534)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GQF42_RS40730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GQF42_40725"
                     /product="hypothetical protein"
                     /protein_id="WP_158928467.1"
                     /transl_table=11
                     /translation="MVGLMVALVVVGAVGLGWRLARYPGGLRYAFSDVHRADRQDLKRT
                     RAAVRTLQGTARQEESQAQIRATQAERAYDRRIDALERKLEQLERPGRGAYDTGLGDLS
                     LYRHVLLFKGKEIPLAGLGVRFDLARNTETMYIHLKRPEGWADLSEYAHETFPEDQVRR
                     FGVRIENAVAAENAFRDLLPEAIRKTGSDLADARADTAEKDGARAALERVRARHSDGPL
                     LAKALAELEAARDRWQRLTGRRPR"
     misc_feature    complement(18601..18615)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.77"
                     /tool="antismash"
     gene            18695..19231
                     /locus_tag="GQF42_RS40735"
                     /old_locus_tag="GQF42_40730"
     CDS             18695..19231
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964142.1"
                     /locus_tag="GQF42_RS40735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40730"
                     /product="AAA family ATPase"
                     /protein_id="WP_376000192.1"
                     /transl_table=11
                     /translation="MRVGTEHTRLIVLRGNSASGKSSVAEGVRDRFGRGLALVGQDNLR
                     RIVLRERDRPDAANIGLIDTVARYALDAGYHVIVEGILSADRYGAMLARLRADHRGPTH
                     GYYLDVPFQDTLARHATKPIAGQVGEADLRNWYRACDVLPGRVETVIGAGSSLAETIDH
                     IMCDTGLSSLPPLDI"
     gene            complement(19696..20619)
                     /locus_tag="GQF42_RS40740"
                     /old_locus_tag="GQF42_40735"
     CDS             complement(19696..20619)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059079.1"
                     /locus_tag="GQF42_RS40740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40735"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_158931186.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.2e-05, bitscore:
                     22.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIFVTGASGWIGSAVVPELLDAGHHVVGLARSETSAAALVEAGA
                     EAVRGTVDDLDVLREAAAASDGVIHLAFKHDIAFSGDFQGAAEADRRAVDTFGDVLAGT
                     DRPFVIASGVAGLAPGHLATERDMPAIDGSPISVRAATSVATLDLASRGIRSCVVRLSP
                     TCHGEGDNGFVPTLIAVARDKGVSGYIGDGSNRWPAVHRLDAARLFRLAVEKAPAGSVL
                     HGGAEEGITLREVAEVIGRQLGVPVVSVAPEAAGGHFGWLGGFVGLDAPMSSTFTRELL
                     DWQPSHPGLLDDLDKGHYFRTPATAA"
     gene            20703..21281
                     /locus_tag="GQF42_RS40745"
                     /old_locus_tag="GQF42_40740"
     CDS             20703..21281
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044137.1"
                     /locus_tag="GQF42_RS40745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40740"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_158928469.1"
                     /transl_table=11
                     /translation="MVRWKPDARGRLAQAALELYGERGYEQTTVAEIAKRAGLTERTFF
                     RHYADKREVLFSGAGELEELFVGAVAGAPQSAAPVDAVALGLDAVAGMFADRREFAGKR
                     HAVITAHTDLMERELTKLASLSAALADTLRHRGVGEPAASLAAEVGVAVFKIAFERWIV
                     HGEERTLRDLVRDSLAELKAVASGDRTHG"
     gene            complement(21929..24271)
                     /locus_tag="GQF42_RS40750"
                     /old_locus_tag="GQF42_40745"
     CDS             complement(21929..24271)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386795.1"
                     /locus_tag="GQF42_RS40750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_40745"
                     /product="glycosyl hydrolase family 95 catalytic
                     domain-containing protein"
                     /protein_id="WP_199272973.1"
                     /transl_table=11
                     /translation="MTSQPEKRSPVPRRSVLGTALGGAAVAALPGTAHAGQPIHSVQSV
                     QSVQSGASAVAGRPWRLRDTMTTDGSWQRFLRGQDLLWTKLPTLWYEGPFLGDGLLGSM
                     VYQEPGANRIRFTVQHGRVQDHRPEFGSGWGTCRLPVGHLTLDPVGTITAVDWRLSLFD
                     AELTGTVTTTAGTLTLAALIHDEVLAARVTATGGEKVTWTFHPEEALSPRHISEAPPTG
                     YTANPPWTTRSTADGTAQVLQPLTGGGQTATSYRRLGDDLLLSVGHSFPSGTAAEADSL
                     RNLRRAPSYGVLRRRHTQWWHAFYRKSFVSFPDQRLQSFHWIQLYKVASASRAGGPVMA
                     TSGPWLEPTPWPAVWWNLNVQLEYWLIQGFNHPELDALATTLRQNQEQLAANVPAAYRT
                     DSSGIGRSSDMFAEREVGQPGTGAETGDLTWALHNVWLSYRHSMDTSLLRDTIYPVLRR
                     AIGYYLHFLAPGSDGKLHLPSTLSPEYPVVPPQDTNYDLALIRWGCQTLIDSARLLGIK
                     DELVPRWQEVLARLTPYPVDDNGFMIGAATPYAQSHRHYSHLLMVYPLYLVNWDQPESR
                     DLITKSVAHWHALTGAHRGYSYTGAASMYAMTGDGDTAIAYLRKFFDPTTRYPCRANTH
                     YTEAGPVIETPLSASQSLHDMFCQSWGGIVRVFPAVPSAWADVTLHNFRTQGAFLVSAV
                     RAAGVTRFIRVKSLAGEPLKLRHGLGGTVTAELDDGTPAHTQDLGDGTLAIGLPKGREV
                     LVHSGSRPDLVIAPVALSEPGPAWGLP"
ORIGIN
        1 tcatttcggt gtcgatcggg cccggatgga cgacgttcgc ggtgatccct cgcgcgccca
       61 gctcccgggc cagcgcgttc gtcagcccga cgaccgccga tttggtcatg gtgtacaacg
      121 tggccccggg ccccggtacg cgctgggtga tgcagctgcc gatcgtgatg atccgcccgc
      181 cgggcgccat gagcgcggca gcggcctggg aggtgaggaa caccccgcgg atgttcacgg
      241 cgatgagccg gtccacgtcg gcgagcgaca ggtcctgcag cggctgcatc acaccgaggg
      301 ccgcgttgtt caccagcacg tccaggcttc ccagcgtccg cgccgcatga tgtaccgcct
      361 ccgtcgcctc ctgtgcgtcc gcggcgtcgg cccgcagggc gaccgcccgc cgtccgaggg
      421 cctcgatgtc ccgtaccacc tccgccgccg cttccttgcc gtgcacatag gtcacggcca
      481 cgtccgcgcc ctgctgtgcc agtcgtcgtg ccgtcgccgc accgatgccg cggctgccgc
      541 cggtgaccag tgccttcctg ccgttcagag gtgcttgtga agtcatgtcc ccatctcatc
      601 ggcggggcgt gaggcacgct ggcggtgaac ggacctcgac ctgccgggga ggatggggtg
      661 ccgtcaggcg aagggggagc cggacgcgga cggcaccctg tcgggagaca atcagaagag
      721 gaaagggacc aggcgcttcg tccgccgcga tagtccgtgt acgccgggcc gaaggccgcc
      781 gtcagcagtc gctcctccgc actgatgcgc cagagatagg acgccgtgag cagcgcggcc
      841 acgatcaggg tcgcgggccg gctgcccagg cccagcgagt agccggccca caccagcagg
      901 ctgccgcagt acccgggatg gcgtatcaga cggtacgggc cctcctggac cacacgctga
      961 tcgtcgaccg tgcgcagcgt acgcgtgtag tactgggcca gggtgtgcat gccccaggca
     1021 cgcagtgtca gcccgccggc caaggcagcg acgccgaacc agcgtacggc tatggggagt
     1081 tggccgaccg acgtgctgcc caacaccgta ttgatcacgg ctgcggccac gtaggagacg
     1141 ataagcagcc gggtcgaacc ccggtcccgg tcgtccgcct gccacgtaac ggcggccgag
     1201 tcctcccgac ggcgcagcag tatctcgtac ccgatccagc acatgatgcc cagcacggag
     1261 aacagactgg ggagagccat cgcgctcgct cctcaccttc ggcgatgtca cgttccacgg
     1321 tcgcccgttg cctctctcga agcacgcacc cacgggtgga aatcgtctcc acccgattcc
     1381 tccacctcgg atctccaccc cacgggcgac accgcacagc agcgggacga cgtgggtgcg
     1441 gcgatgtgcc ggaggccggg cgttgtcagt gccgggacgt agtggtgccg ggcatgtccc
     1501 gctcctggtg cggggcccga atccgcagac gttgggagca ggtcccctgc agttccgaac
     1561 cacccgttgc gggcggcact cggcgcggtg tacgcggccg ttgcccacgt acggcgagga
     1621 ctgtccggtg ctgttgcggg aagtctggtc cgtatgcgag agccgttagt cggcctatat
     1681 gaaataaggg ggcggaatca tttcttcacg gcggcgaccg ttagggtcgg cgggtgaggg
     1741 tacgtcacgg gagaccgaat tcctcgaata cctgctgagg gatgtgtgca tgaccgaggg
     1801 ggtggatgca gggcaggcca acggggcgga ggaggcgggc gttggtgcag cgccgatcct
     1861 gttccgcgcc gaactcttca ccctgaccgg agattcggac aacaaggatc cggacaccgg
     1921 cactcacctc accgtgaaaa ccggtgacga aaaggccctg ccggcctcga tcaacaacgc
     1981 ggacagttca ggcatggaca tgaccaccta cgaggacgac tcccaccaca tcgtgccgct
     2041 ggctgtcgag gcgcccggtg cacgcaagtc ggactgcgac gggttcaagg tccggatgtg
     2101 gatcaagacg aagggcagcg acaactggcc cgtcgacgac gcccgcgtca cgctctgctt
     2161 cagcgacggc acgaccctcg tcgccgagaa gctcggcttc agcctcaacg gagacggggc
     2221 caccgccgag ttcgcctcgc tgtagcgcgt accgcgggga cgtccgcaca aaagcagccg
     2281 gcggcggtct ctgggggagc gggccgccgc cggcacaccg ctcgggcgga accaccgatc
     2341 tgcctgtggc acgacgtggg gcggggacat gatggttcca tggggttgtc gacagtgttt
     2401 gcgcatttgt ccggtgtgga gcacccggtc gcgccggcgc cgatgggcgg ctgggccggt
     2461 ggcgcgctcg ccggcgcggt ctcgcgcgga ggcgggctcg gactggtggg gggcgggacc
     2521 ggcgatctgg ccggctccga cgcgagctgc cgctcgtgac cgccgaaggt gccggaagac
     2581 gaccagctgt ccgccgccga tccggtcggc gtcctggcga cccaggcgga gggcggactg
     2641 gcccgcgcgg gcagaggctg agcgcgtccg tcccgtcctt ccggtacgac cggctcgact
     2701 tgctcggtct gtccaccgga gcatccggct cactcggcgt cgcggactcc agggcgcccg
     2761 ggcatggacc cgcagcgggc agtgggtctt gcgtggcggc ggcgacacgg agttgctgcc
     2821 tggtcggtcg cgctcgcctc ggcgggctgt tccacggggc gcgcatgagc aatcgccccg
     2881 cgcatgacac cggttgcacg cctggcgccg accaggcacc gggaacttga caccgacgcc
     2941 ccggctcgtg cccgggacac agaggcaccc gccctcagag gcaccgatcg ccgcccgagt
     3001 cgcgccgaga ctccccggga cgcgacgacg gcaccccccg ggacataccc cccggcccgg
     3061 gacgcggcga cacccgcccc gggacacgcc gacactgcga cctccggcag aggtgcacca
     3121 actcccgccc gcggcccgcc ggcccctatc cggaactccg cagacatccg tcgccgtcgg
     3181 tgcccgaaac cggccctgag cagcctgaga cctccttcga cgccccggcg gcacggtcag
     3241 aacggcggcg ccggggccat ggcctactgc gcggcgtcag gtccgctctc ctccttgcgt
     3301 gcggcacccg gtgccggcgt cgactccgcg gaagcgctgg gaacggtgta gaagacggac
     3361 gtgccctgct tggtgcgctg ggcgttgttc cgggccacga ggttctccag cgtggtgcgg
     3421 atgaccttgg tctggatctc tcgcgcaggg tgtgccttgc cgagcgcctc ggagacctcc
     3481 gcagcggagc gcggctcctt ctgctccgcc aggtggcgcc ggacgagctc gacgagggtg
     3541 ggctgacccg cctgcggggc cgccttcttc gccacggact tcttcgccac ggacttcttc
     3601 gcgtcggact tctccgcgtc ggacgtcttc gcgtcggccc tcttcgtcgc gggcttcctg
     3661 gcagggctct tcctggactc ggcctcctgt tcggccgcct tcttaggcgg ctgctgcgtg
     3721 ctggtgagta cggtgggcgt cttgcgcggc gcaggcacca cggcgccttc ggtgacggca
     3781 ggtgtgccgg ccggggccgc gaccccgagc gcctgctgca tgctcaccag aacggtgtgg
     3841 tcgtgctgca gaccggccaa ctgctcctgc agggcggaga tttcggccgt gatgcggtcc
     3901 tgctccttga cgttgcgttc gaggtcaccg gtcacctggt tgacgtactg cgaggtcaac
     3961 tgggtgacgg gtgtggtgtt ctccgacatc tgtgtctcca ttcctgacgg tgaaaacgcc
     4021 ggttcctcgc ggccgcttgc ggcaggcggg gagcggaagt tgcgcttcag ggcgcacaac
     4081 acatggatga tacgggtggg tcggcatgtt ttctgctgag tgaaccctgt gcgttgcgtg
     4141 ccgacaagat gtgccgcacg ggccgttcag gttattcatg tgctgtgccg accccgcctc
     4201 ggggtgaatg cgcgagtcat tcggcggcgc gccataaccg atggccgcgg cgcaaagagg
     4261 tccgcaccat gcctgccatg ggaactccca cctcctacga cggcaccgga ctcgcctacc
     4321 gggcctccgg ggacggcacg cccacggtgt gtccgcccgg cgggccccgg ccgtcagcca
     4381 cctcggtgac ctgggctgac tgtccgcgca ccgcacactg atccgactgg acctgggggg
     4441 caccggtggc tccgccatgt ccggggacat ctcctcctgc cggtgtgacc gcatggtcgc
     4501 cgatgtggaa gccgggagga accgtggttc gcgacgaagt tcgcggcgct gcaggccatc
     4561 ggagcgggtg cggccacggc ggagaacttc caggccatcg ctctcctctc atgcgggcgt
     4621 tgggacgagg cggcccgggc gcacaaggct gcggaggacg aacagctgaa cctggcggtc
     4681 gtggcggctt tcggcgcgcg gggtgccttc gacccggaca ccacgcgcag ggcgctcgcc
     4741 gctaccgcaa gcccgcggtg gtggtcgccg gggaggtcga cccgggcgcg cctgtgcccg
     4801 ccgcggccga gttcgccggc ctgttcccgc acgccgaact cgtcgtacaa ccgggtgccg
     4861 gacacttccc ctggctggac gacgcggacc ggttcgtggc ggccgtcatg acgttcctgg
     4921 gcgggctgta gcatcgcggt catggccgac tgggggatac ggcaggcgtc ggccgcggac
     4981 gtcgaggcgg tggccgcgct gcgggccgtg gtgctgagag cggatctgga gcgtttgggc
     5041 cgctacgacg aacaccgcgt ccggcagcgg ctgcgcgacg gattcgtccc ggagcacacc
     5101 tgggtgatcg agacggccgg agccctggcc ggctgcgtgg cgctgcgggc ggcaccggaa
     5161 gcccactggc tggagcactt ctacctgcac ccggcactcc agcgcagggg catcgggtcg
     5221 gccgtgctga ggatgctgac ggcgcgctgc gaccgggagc gggtccgcat ccggctcaac
     5281 gtgctgcggg gcagtcaggc ccggtggctg tacgagcggc acggtttcac ggtcgagtcc
     5341 gaggacccgg tcgacgtgtt catggtccgc gagccggctg cgggcggtca gggcgtgtcg
     5401 gcgtagcggc tgtgggcgcg tacggcggcg gcgaccgcgg cgtcgtcgct ccggccgcgg
     5461 gcctccaggc cggctatgac tccttcgacg ttctgccggg gctggttctg gctgagcttg
     5521 gccttggcct cgatccggct gatgaccagt tcgacgccga cgaccgcgcg cagctggcct
     5581 tcgaggaact tcgccggggc ctggtcgacg gaccagggct cggcggagcc ggcctcgtgc
     5641 cggtcggtga gacgccgcat ctgtgccacg atccaggccg gatcgtcgtg tacggccaac
     5701 cggccgtaca cgtgtgccct cacatagttc caggtcggca ccacacgatg atgctccgcc
     5761 ttcgtcgcgt accacgtggg cgacacatag gcctgcggcc catggacgat caccatggcc
     5821 tcgccctgca caggctcgcg ccagtgaccg ttcgcgcgcg ccatgtgtcc gatcagggcg
     5881 ccgtgttcac cggtgtccgg gtcgtactcg aagggcagga gggtggccag caggccctgc
     5941 ggggtcatgg tcaccaggtc ggcggctccg aggtgggtga gcagtgcgcg gacgtcggcc
     6001 tcgtcgggcg tgaagggctt gggaacgtac acggatgggc ctttcggtca gtcggagtgt
     6061 gcggtggcgg caccgccgcg gagcgggttc tcgcgcagcc agctcagaac ctgctcggcg
     6121 tgcgcgttcg gcgggaagac cggatagaag acgtgctcga tcacgccgtc gcggacgacc
     6181 agcgtcagcc gcttgaacag acgcatcccg tcggcctcga acgtgggcag gcccaggttg
     6241 ccggccaggc cgagtgcggg gtcggagagc atgtcgaagg gcaggccgag gcgttccacg
     6301 acctcgttct ggtagccgca gtcctggctg gacagcccgt acacccggcc ggcgccggct
     6361 tcgaggaggt cctggaagtg gtcgcggaaa ccgcatgtct cgggcgtgca gccgcgggct
     6421 ccggggatgg agttccagcc ctccggcagg tccgtccccg gacggccggt gagggggtag
     6481 acatacacga cggtgcgacg aggtccgagc gcgtccaggc ggatcgccct ccccgccgtg
     6541 tcgagcaggg tgagcgcggg catcgcggta ccggccaggt ggtccgccgc accgtcgtcc
     6601 tcgggggtgg gcaggtccgc cgggagtgtg aggtagtcct cgccgtcgcc gtgcgccgcg
     6661 ggcggtacga cggcgctgcc ccggcgcgcg gcggcgttga ggttggcgat cagcgtggtg
     6721 cgacgggcgg tcagggcctc gatgcgctcc gtcagctcgt ccacggcttc gcgataggtc
     6781 gccagcgagg cagggcagtc gtccgcatag gcgcttccgg cggccaggca ctcgaggaag
     6841 ggccgggtgc gctcgacggg gatccccagt cggtgcagag ccctgatctc ccgcacaagg
     6901 cgtacgtcgt cctcgtcgta gtcccggtag ccgttggcga ggcgcccggg tgtgatcaac
     6961 cccagcgact cgtagtaccg caccgctttc gtcgtcacat ctgcacgacg cgccagctca
     7021 ctgatcttca tgccgttcac ctcgctcaac gctaaacctt gtccccgggg gcaaggtcaa
     7081 gaccgaaggt atgggcctgg cccggagcgg accggacgtc gaccgtagcg ccaggtcaac
     7141 gcggtgtgac gggtgtgccc tgggagggtg gacatgcgag tgcgggaggt gttatgggct
     7201 ggttcgtgcc ggtgtgcttc ctaggctgcc gccatgaaga tccccaccga acccatcggc
     7261 agcctcccgc gttctcccga actgctcagc gccatggccg agttccagtt gggccggatg
     7321 gacggagccg cgctcaagga gatccaggaa cgggccgtcc gtgacaccat cacggagctg
     7381 gaggcggccg ggtctccggt cgtcaccgat ggtgagcagg ccaaggccag ctttgtcacc
     7441 taccccctcg cgggctcgcc ggggctttcc cccgacggtg tcgtgatccc cttcgcggac
     7501 gggcaccagc gtcggctgcc cgccctgacc tccgggccct tccgctacaa ggtctccgca
     7561 gaccagtacc tgcgggccgc tcagcagcac accaggaagc cggtgaagca ggccgtcgtc
     7621 gcgccctcga tgctgagcct gctctacccg gccgccggga tctcggggta cccgcgcgag
     7681 gagttcctcc accagctggc cgacgagtcg gaggcggaga tccgtgcctg tctggacggg
     7741 ggtgcacatg tcgtccagct cgacttcgac gaggcccgcc tctgcctcaa gctggatccc
     7801 ggcggaaggc tgctggacga tctggtctcc ctgaacaacc aggtgctggc ccgcttcacc
     7861 gagagcgagc gggcacggat cggcgtctac agcgggcccg gcgcggacca ggactccacg
     7921 cacagcctcg acgtcgacta tgccgagctg ctgccccggc tcttctggct cacggtgggc
     7981 aatttctatc tgcaactggc gagcgagtcc gacccggacc gggtcctgac cctgatcgcc
     8041 gaccacctcc gccccggcgt cagggtcttc gtcggggtga ccgacccgat cgacccgcgt
     8101 gtcgagacgc cggacgaagt ccgtgaccgg gtgctgcggg cggcgaggca catccccgtg
     8161 gaccagctgg gcacctgcga cgacgcgggc ttcgccccgt tcgccgacga cgcctccacg
     8221 tcccgtgcca cggccttcgc caagatccgc gcccgtgtcg agggcaccgc cctcgccatc
     8281 gaggccctcg gcatctgagg ccgcgcccgg tccgtccggc cgatgtggcc gaccgaccgt
     8341 gtccggccct ctgcgagccc ggatcaggat ggccgtgccg tggagtgcgg ccatcacccg
     8401 gctgtcccgg gggtcgggga accgccgccg cgtccagcac tcgtcgcgca gccggcagga
     8461 gtcctgagcc gtcgagtgcg ggccgttctc gttccgctcc ggggccagcg cgtccacggt
     8521 gtcggcaaag gcctggcgca acgacctgcg gaacagatgg cggcccggcg cggcggcggg
     8581 gcgcagaacc gtgcggccgc gtaccgccga ggtcaggccc gtgtcccacc tgccgtcgct
     8641 gtgcggccga ggcgttgcct tgagtgcggc gccggccagg cggtgctcga tgcgcgcctt
     8701 gaagaacgta ccgacgggac gccgcacctc ggccgccggc tgccgccatg cgtgcggatc
     8761 ggtacgtgcg ctgcggtggg cccgacgcag tgacgaccgt gtgccgaagc cccctgccgg
     8821 ccatgccggt tcggcgtcgg caggccgctg ggtggtgcgc agcgtgccct cacgcgggga
     8881 cgagcctgct ccccctcctt ccggtcgtcc ccgacttcgt caccgggccc tgccgcgtac
     8941 cggcacagcg gcggccgccg gtgctcatcg ctcgaagcgt gatctgccga gagtgacctg
     9001 gtggccgacc atgctgatct cgacgccgtt cgcggtcgag cgtgccgcgg tgaaacccgc
     9061 gccgtccggg agcggcacgc gccaggtgaa cgccgactgc cccgctccgg gaactgtcag
     9121 gccgagttcg gtgccctggg cgaggagcgt gcccgtgctg tccagcggtc ttccggcgac
     9181 tgtccccgtg atcctgagct tggcggcctg gtccgccgag ccggggggct gagacacgcg
     9241 caggggcccg ccgctgccgg cgagccgcgt caccacgtcg gacagttcgt cgtacgacag
     9301 cgtcagtgtg ccggtggcta tgttcgcctc ggcgctgcgg gccgacaggg acgtcacctt
     9361 cacatcgtgc aggtcgaggt ggaactgctt gacgtgcaga cagccgccct gcgcgttggc
     9421 cgtggtgtcg acggtgaact gcccggccga gaggctgaca tggccgaagt cctggctgaa
     9481 cacctgtgtc aggaacggga aaccctcgat ggacacgtcc acgtggctgt cggtggtgtt
     9541 gccgtagggg tacttctcct tggcgagccg ttcggcctcc ttgtccgcgt agtgcaggga
     9601 cacgcggtcg gcgaccgtga acaggacggc cggcacgacg accgcgatcg ccaggaattt
     9661 cacccatcga cgttgcatac cgaccccacc ccgtcgtccc ggccccgtgc cgcacacgat
     9721 cagtgcgcgg actgatcatg cacggtcgtc ggcccggaca acagccctgt ggacaaagcc
     9781 ctgtggacat cggccgacgg gcatcggccg atggcaaccc cgtggttccc atgcacccgg
     9841 ttggacgcgc gggagtgcgc cttgggcgtg gcatgtgccg tatgtgcacc aggcgtaacc
     9901 ccgttgatca tatgaaaaat tgccgtcggt ttttcaggtg ggaggaattg cggaattccg
     9961 atgacaggag cgcactttcg tcggttgcca gggaaggacc atggtggagg tcgaacgctt
    10021 gctggccgat tgtctccagg atgcccggaa catttctctg ggcacggtgc cggtcgtctc
    10081 cgaggaaccc gcatatacgg cggtccgccg cacctttctg acggccgggc tgtccgcgct
    10141 gcgtgtgaat ctgccggaaa cgaactgggt ccaggtcaat ctctcgcccg gtccctcggc
    10201 ctggcaacag acgtaccgcc gtatcgcgga cacggcccgc gccctgatcg ccgcggacct
    10261 ggtgggctcc ttcttcttca tgcacaaacc tcccgggctg cgggtacggt tcgaggcccg
    10321 cggggccggg cacgggctgc tgcgtgcgga gctgatccgc cgcttcggcg acctcgacgg
    10381 acagagcgcc gcgccgcact gcgggacgta cgaaccggag acgtacctct tcggcgggcc
    10441 gctgtcgatg cggctcgtgc acgagctgtt cacggcggac tcccttgcct ggctcgacca
    10501 gcacaccacc accccggcgg acggcggtcc ggggccgctc gcggactggc ggctgtccct
    10561 ggtgctcctg ggggaactcc tcgacggtct gggcgtcgtc ggctgggagc accgaggggt
    10621 gtgggaggtg gtgcgcgacg acaccggtcg caggctgggc acgatcccgg acgaggacac
    10681 ccgccgggcg gccctcggca tcctcgacgc ctggcgggcc ggcccccggg cgctgctggc
    10741 cccgcttccg gacgagcagc ggtcggcggt gcgggcgcat gcggaggcgg tgcgccggtg
    10801 cgccgagcgg tggcgcaccg ggtacttcga gtccggcgag gcgatcgtcg gcccgcgccg
    10861 cgccgcggcc cactacgtga tcttccactg gaaccgtggc cggctgtccc tcgcccggca
    10921 gagcctgctg acccacgccc tcgccggcga cggaaggttc tgacatggcc caggacccga
    10981 cgctgggcgg caccgcgctg ctgagagtgg ccgggatgcc cttggccgcc tggacgcagg
    11041 cgggcagccc ggacctgttc gcccgcctcg ccgagcacac ccgcgaccgc gagcggcgcg
    11101 ccgaacgcgc ccgcgcactg gccgaacgcc tgggcgccac cgtcgtaccg catcccggcc
    11161 tgaccgccgc cgaccggcgt gccgtcctgg ccctgcgcag gcggttgcac tccggcgcgg
    11221 ctccgggtcc ggcgggctgc cggctgctgg agcgcctacc cgccgcccgg gacctcactc
    11281 ccgaggccgt cctgctgtgc gctgaggcag agtcggcgga aaaggccctg cgcgaggtgg
    11341 agcggacggt cgcggccgag cgcgcgcggg tgggcgcgct cggctgggcg ctggtgtgca
    11401 ccagcccggt catgagggcg ttcctgcagg aggcggcacc gggcgtgccc gcggacgtcg
    11461 tccggcggct ggccgagggc gagtcctggg aggggcagcg gctgcgcaag cgcggggcgt
    11521 acctgtggcg ggccctgggc cgggccgcgg cgaagaccac cccgcgcggc tgggccggcc
    11581 aggtcgtccc gctgccggtc gccccgacgg ctgcgcacca cggccacgga tcgcggctcc
    11641 ttccggccgg ggcgacactc ggagcgctgg ccgcagaagc cgtcgagaac gtccatctgc
    11701 tgcgtggccg gctcggtgcc ctggacctga gggcctccgc ccccgcgacc ctcgtggccc
    11761 ccgcgccgct gcacttcctc gaccccgcgg gcgacgccac gcagacgggc acgggcgtgc
    11821 tgcggtgctg ggtcatcgac cagcaccagc gcggcagaat gcggcaggtc gtcctccggc
    11881 gcacccggcc actggacgcc gtactcgccc aactggccga tgggccacgc acgttgggag
    11941 acgtcgaggc ggcactgctc ggcacggccg cgatccgcgc ggccgacccg ggcccggccg
    12001 tgctgcgcgg cttcctcgcc cacctggtcg aactcggcgt actccaggtc tgcgcggccc
    12061 cgcgccgccg cagcacggca tggctgcccg cacggcaggt actggagcgc aacgtccttc
    12121 cccgccccgc cccgacaccg gccgcacaac gcggtgccgc cctgcgcgct cacgacggtg
    12181 acgtcgtcgc ccgccacggc ggtgccaccg gcgccgcagc gccgagcggc ggccggtccg
    12241 ccgcagtcgg ctcagccccc tcgccggggc gcgaccgtga cgccgccgca gcggcccgca
    12301 tgcccccacc gggccacgac catggcgccg acgcgccggt gccgcgcggc gactgcgccg
    12361 ccgccgcgca caccggcggt tccggcgcct ggttcatcga ctcgtaccgc accgtctcgg
    12421 ccgccgtgcc ccgcgaggcg gtcgaccggg tgcagcgggg gctgcggatc gccgcccgcg
    12481 tggcccggct gcaggaagcg gaccggatcc cggccacacg cacgcgtgcg ccggccccgg
    12541 aactcgcggc actggacgaa cggccgcgcc ccctgggcga gatcctcgcc cgcaacctgc
    12601 cggacggcag ctgcccgccg ccctcgccgc agacccctcg caggtacacc ggctggcacc
    12661 ccgccgagac cacggactcc ggctacgccc tgctgctggc ccacctggcc gcgcacaccg
    12721 gcgaggaaca ggtggacctg gacgacgaac tgctggacgg tctcggcgcg ccaccggccc
    12781 ggacggcgct gccgccctgg ccgctggact gcctgttacg tccgctgccg ggccccgggc
    12841 cggtcgcggt gctggagacg gcctcgcccg cgggcatcct cgacgcccgg ttcgcggacg
    12901 cactgcacac cctgttcggc ggctatgcga accccaccgg ctaccgggcc ttcctcagcg
    12961 gtgtggagcg gctgacgggc gcacggttcg tggagctgct ggtgcccccg ctggccgagc
    13021 gtgccgccaa cgccgtacgc cgccccgtcg tcaccgagtg gtggaccggc gacccggacc
    13081 ccgccccgta ccaggggccg gccggctcgt ccgcccgcta cctggccctg gaccgcatca
    13141 cgctccgccg gcacggagcg caggtgatcg ccgaggccga cggccggcgc atcctgcccg
    13201 tccaccacgc cacccgatct ccgctgcctc cctacgacgt cctggtgcgg ctgctgatgg
    13261 ccgcaggcca cccggccgcc tcacgagtga tgcgcctgga cggcacgatc gaggcgcttc
    13321 ccggcgccga gcgcctgccc cgggtgaccg tcggcgggga cctcgtcgtc agccccgccg
    13381 tgtggcgggt gccgcgcacc cgcctgtggc ggccgggcga cggcgacctg gccaaggcgc
    13441 gtgcgctcgg cgccctgcga ctcggcgccg ggctgccccg cttcgcgttc gtacgagccg
    13501 taccccgggc gaagccggtc cccgtggact tcgagtcgct gaccgccctg caccaactgg
    13561 agcggatctg cgcgcaccag ccaggcccgg aactggtggt ggaggagatg ctccccgccc
    13621 ccgggcaact gctgctccgt gacccgctgc acgaaggtgc ggccgtggcc gcccagttgc
    13681 tgctgagact tccgcacgag cagagcgccg gagaactcgc ggcgctcgcc gccgccgcac
    13741 tgcgcggcgc cacagacgtc cccggggcgc gcccgtcggc ggcgggccgt caccgaggcg
    13801 gcgcacatcc atcccgtccc ctgaaggagg acagcaatgc ccgaaatcat gcaactcagc
    13861 gacctcgacg ccctcatcgg tgacctggag acacggatca ccgagagcac tctgccgtct
    13921 gcggaggccg acaccggcgg ttgtagcggc gtgtgcacgg tcatcgtctg cgacacggtg
    13981 gtggtctgca gcggcgtcgt gtgctgacga accgtcagta gaccgctccc gcaacggcct
    14041 cgggtcatgc cgagcgaggc tctcgacccc cttgtgacgg tcctgggttg cgagcgctcg
    14101 tgacccggga ccgcggtacc ggcgtcccgc ccgacccctc cgatcccgcc cgggcgggac
    14161 gccgaccggc tcttggcttg tggctctgcg ccccgaagga gccgtcgttc cgcactcccg
    14221 aggaggcgcc atgccgcagg gcacccacca cgccgagcac acccgttccg ccgtcaccgc
    14281 actcgcgggc cggctcctgg acgcctggtc cgccagggcg cgtgacggtg ccgtggccgc
    14341 cgagcacccc tgcgaccccg gcgtgcccgc gctggcggcc ctgctgcacg acgtggggga
    14401 gcaggcaggc gccgcgacgg cggcccgcgc ggtggccgtg tgggcccgct cggcaggccg
    14461 cggcccgggt catcccgccc tgtacgacgg agggctggcc ggaaccctgg tgggcctgcg
    14521 tctgggcgcc cggctccacc ctcaactgca cgtggccgcc gaccggttgc gcgaccggct
    14581 ggtgcgcatc gcgccgacgc gcggcccgcg ccgtgacggc gtgaccttcg ccgactacga
    14641 cctgatcatc gggccctgcg gcaccctgct cgcgctgtgc gtcgacgccc gtccgacgcc
    14701 ggcccaactc gagccgttcg ccggacacgt tgcggcgttg tgcgatgccg aggacctgcc
    14761 acggctgcgc acggcgggct atgccggcca tccacatctg gactggctgg acgggcgcgt
    14821 caacaccggc atgggacatg gcgtggccgg agtcgtcgcc gcgctcaccg ccacggtccg
    14881 ccgcctgggc ccacgccccg acctgacccg cgccctgcgc cacgccacgc ggtggctggc
    14941 ccggcagtcc ttcgacgact cccgcgccat ccgcacctgg gacggtgccg gactcgaggg
    15001 cccgccgccc accgggccac gcgcccgcca ggcctggtgc tacgggacgc ccggggtgtc
    15061 gtgggcgctg tgggacgcgg cggacgcact gggcgaccag ggagcggccg cctgggccgc
    15121 gggcgccttc accacgctcg ccgaacacta cgacgagacc ttccacctct tcggtgaccg
    15181 cccggccgat gtcctggccc tgtgccacgg cgcggcgggc gtgctggcgg tggccgacgc
    15241 cttcggtcgc cacgccggcc tgcccggggc agatacgctg aaggcgcggc tgctggacca
    15301 cctgctgcag cgcctgcccg aactgcacgg cctcggcgag gaggccatgg gactcctcgg
    15361 cggagcggcc ggctcgctgt gtgccctgct caccgcggga cagggcgcct cacggacgtg
    15421 gctgccctgt ctcgggctgc gctgaggaac ggcgtgactc aggagggcgg tgtggctcag
    15481 gaggtgtcct gccccggccg ccgcaggaag ttgggggcgc ccgttcggag cgcccgtacg
    15541 ccggccctgt ggcgtccgcc tgtgcctgtg gcaccacagg ggtgaggccc tcctgctcgg
    15601 cggcggtcac caccgcagtg ccgtcggacg gtacgtcgcc ctccgccacc gtcaagacaa
    15661 agcggcccgg attccgccac cgtcaagaca aagcggcccg gattcggctc cggaggtctg
    15721 ccgctgagca gtccgcgcag accggtcccg ccgggcacgg acccgcggta cgggtccgag
    15781 cgggcgtcac gggcatgcgg cagcagtgcc gtccgcgagg tgcaggacgg cgtgggccgt
    15841 gtccagggcc gcctggtcga gggggaagta gccctgctgc gcagtggtgt cggtgcgcgt
    15901 gcgggcgggg gagagtgtgg cgaccgccgc caggccccag gtgggaaaac ggccctggag
    15961 agcaccctca taggtgtccg ggcccggatc ctggaggccg agggcctcgc tgcgtcccag
    16021 gctgccggcc acgaaccggt accgctcgcc gagcaggggc gccacgatgg cgccggctcc
    16081 ccgccagtcg gcgctcacgt cgcccaggcg ccatgtgctc ggggcgcctt gcagatggac
    16141 gttgtgggcg aagaccaggg tggcgccccg ctccgcctcg atgtcccgga cgtccagcag
    16201 gttctgggcc atgagggcgt cccgggtggc catcagagcc gtgatccggg gtccggggtc
    16261 gacgggttgc gtcgccgact gatggtggta acgcagcagg ccgaggccgg cggtgaggtg
    16321 tgtcctggct ctgcgccacc gctcgcgcga ggtggcagcg atcagttcgg gagcgcggga
    16381 gtcgagcgag gtgagcatgt cgttcgcgat cagacgcagc tgctcggcct cgggcgtggc
    16441 cccgggcgac atggccgggt ccatgaccgc ctccgtgcgg ctccaccgct cgtcgtcgcc
    16501 ggcgaggccg gtgatgtcca cgtccagtcc caggtaggcg cgggcgtgtt cgagacagtg
    16561 gcgcgggctg ggtgcgctgt agttctccgt cggggcgtcg aagccgtgga aggtcagccg
    16621 ttcccgcgcc gaccggtgct cgttgtgggc ccgcatccag gcgatcagtc gccggttggg
    16681 tgccagtgcc ccccagccgt gcgagaagcc ctcgctcatc acggcgtcga ggtcgccgga
    16741 tcccccctgg acgtagtcgt tcacggcgag cgcggccacg cggtcggtct ccagggccac
    16801 ggaccggaaa ccgcactcga ccagctgggc gaacagttcg ttgcgcaccc gcccgaaggc
    16861 cggttcctgg tgggtcggct cacccagggc caggaggtcg catgacggag tgaggaagtc
    16921 gcggatgtcc tgagtcatgg acctcaatcg tatccttgat atgtcgattg agacttggag
    16981 acggaacagt ggccgttctg cggtaggtgc ttctgtaaag tctcaaccgg tgagtatcat
    17041 gcgacctacc gacctcgcag tcgagcacgg catctcgacc caggccgtcc gcaactacga
    17101 gcgagacggg ttcctccctc ccgccgaacg cacaccgagc ggctaccgga tctacaccga
    17161 ggcgcacgcg gccgcgctcc gcgcctttct cgcgctcgtc ccggcgtacg gacacgcgac
    17221 cgccggccgg atcatgaacg cgctgcaccg ggacgcactg gacgacgccc tgacgatcat
    17281 cgaccggggc cacagccggt tgctccgcga ccgggacacc ctcgacgcgg tgcgcacggc
    17341 cgtgggccac ctgacagccg actccaaggc ggctccgccg ccttcacggg agcccggcac
    17401 ccggaccgtc ggcgaactcg cgcaccggct cggtgtcact ccggcgaccg tacgcagctg
    17461 ggaagaggcc gggatcctca accccgcccg ggatccggcc accggatacc ggctctacga
    17521 cgccgccgac atccgcgacg ccgagctggc acacctcctc aggcgcggag gacacctcct
    17581 ggaccacatc gccatggtcg tccggcagat ccggaccgcg ggaggcacgg acgcgctggc
    17641 cgcctccctc gacgcctggc agcgcagact caccgcacag ggccttgcca tgctgcgcgc
    17701 ggccacgcac ctcgacacct atctgggcct gctcgacccc accgcaccag agccgttcac
    17761 ggggcatcgg ccgcgacccg agtgagccgt acctcagcgg ggacggcgcc cggtcaggcg
    17821 ctgccaccgg tcgcgggccg cctccagctc cgccagggcc ttcgccagca gggggccgtc
    17881 gctgtgccgg gccctgaccc gctccagtgc cgcacgggca ccgtccttct cggcggtgtc
    17941 ggcccgggcg tccgccaggt cggaccccgt cttgcggatt gcctccggga gcaggtcgcg
    18001 gaacgcgttc tccgccgcga cggcgttctc gatccggacg ccgaagcgtc ggacctggtc
    18061 ctcggggaac gtctcgtgcg cgtactcgga caggtccgcc cacccctcgg ggcgcttgag
    18121 gtggatgtac atcgtctcgg tgttcctcgc gaggtcgaag cgcacgccca gtcctgccag
    18181 ggggatctcc ttccccttga acagcaggac gtgccggtac agggacaggt cgcccaggcc
    18241 ggtgtcgtag gctccccggc ccggccgctc gagctgttcc agcttccgct ccagggcgtc
    18301 gatcctccgg tcgtacgccc gctcggcctg ggtggcccgg atctgtgcct gcgactcctc
    18361 ctggcgcgcg gtgccttgga gcgtacgcac ggcagcgcgc gtgcgcttca ggtcctgacg
    18421 gtcggcgcga tggacatcgg agaaggcgta acgcaagccg ccgggatacc gggcaagccg
    18481 ccaccccagg ccgaccgcac cgacgaccac gagcgccacc atcagtccga ccacgcccac
    18541 ggatcctccc acccgccccg ctccgcgccg agggcgcggc ggccgactcg gcttcctgcc
    18601 aacttcctga atatcggcgg gtgttggcct tgcgtcaaca gcgccgtcgc ggacgtcatg
    18661 ggccgggtcc gtgcgcagcg gtagcctgcg gcgcatgcga gtcggtaccg aacacacccg
    18721 gctgatcgtg ctgcgtggca acagcgcctc gggcaagtcg tccgtcgcgg aaggcgtccg
    18781 agaccggttc ggtcgcggtc tggccctggt cgggcaggac aacctgcgcc ggatcgtgct
    18841 gcgcgaacgg gaccggccgg acgcggcgaa catcggcctg atcgacaccg tcgcccgcta
    18901 cgccctggac gcgggctatc acgtgatcgt ggaaggcatc ctgagcgccg accgctacgg
    18961 cgcgatgctc gcccggctgc gcgccgacca ccgggggccg acccacgggt actacctcga
    19021 tgtgccgttc caggacaccc tcgcccgcca cgcgaccaag ccgatcgccg gccaggtcgg
    19081 cgaggccgac ctgcggaact ggtaccgggc gtgcgatgtg ctgcccggga gagtggagac
    19141 cgtcatcgga gccgggagtt ccctcgcgga gacgatcgac cacatcatgt gcgacacggg
    19201 cttgtcctcg ctgccgcccc tggacatctg agaccctcgg cgaaaggccg cgggccgagt
    19261 ggccgacgac gcccggcagc gaagcggacc ggagccgcac cgagtccgag aacaggcgtg
    19321 tcggcgacgg ctgggccccc cgtcgtggcg gtgggccttt ggcaatcgga gcccgcgagc
    19381 ccggcccgag ccgcccgccc gcgtctgccc cggagcacac ccgcggccgt cccgcccgag
    19441 ccggatccgg ctcgggcggg acggccgtgt tccggaactc ggcggcgccg tggctcagtt
    19501 cgtacgtcca tcagccacag gccggggcgg atcttggcgg cggcctcgtc gacggcgagg
    19561 ccgcgggccg ccgcctccgg cggcccgcgg cgcacggtgc cggtgagcgc gggcccctgc
    19621 caccagcgga cggagttccg gctgcccgct cggtggccgt gatcaccggg aggggatgat
    19681 gtgtcgccgg gccggtcagg cggcggtggc gggtgtgcgg aagtagtggc ccttgtccag
    19741 gtcgtcgagc aggccggggt ggctcggctg ccagtccagc agctcgcggg tgaaggtgct
    19801 cgacatcggg gcgtcgaggc cgacgaagcc gcccagccac ccgaagtgcc cgcccgcggc
    19861 ctcgggggcg accgatacca ccggcacccc gagctgacgg ccgatcacct cggcgacctc
    19921 gcgcagggtg atgccctcct cggcgccgcc gtgcaggacc gagccggcgg gcgccttctc
    19981 gaccgccagg cggaacagcc gggcggcgtc caggcggtgg acggcgggcc agcggttgga
    20041 gccgtcgccg atgtagccgg agacgccctt gtcgcgggcg acggcgatca gggtcggcac
    20101 gaatccgttg tccccctcac cgtggcaggt cggtgagagc cgtaccacgc aggagcggat
    20161 accgcgcgag gcgagatcga gcgtggccac ggaggtggcc gcccggacgg agatcggcga
    20221 accgtcgatc gccggcatgt cccgctcggt cgccaggtgg ccgggcgcga ggccggccac
    20281 gccggaggcg atgacgaagg gacggtcggt gccggcgagc acgtcgccga aggtgtcgac
    20341 ggcgcggcgg tcggcctcgg cagcgccctg gaagtcgccg gagaaggcga tgtcgtgctt
    20401 gaaggcgagg tggatcaccc cgtccgaggc ggcggccgcc tcgcgcagga cgtcgaggtc
    20461 gtcgacggtg ccgcggaccg cctcggcacc ggcctcgacg agcgcggcgg ccgaggtttc
    20521 ggagcgggcg agcccgacga cgtggtgtcc ggcgtccaga agctcgggaa cgacggcgga
    20581 tccgatccag ccggaggcgc cggtcacgaa gatgcgcatg ggaagcccca aagagtcgat
    20641 gtcagtgact gtcatagacg gtacacctga tgtcagcacc tgtcatcacg taggatctgc
    20701 gcatggtgag atggaagccg gacgcgcgcg gacgccttgc gcaggccgca ctggagctgt
    20761 acggcgagcg cgggtacgag cagaccaccg tggcggagat cgccaagcgg gccgggctca
    20821 cggaacggac gttcttccgg cactacgccg acaagcgcga ggtgctgttc tccggcgccg
    20881 gtgagctgga ggaactgttc gtcggcgcgg tcgcgggagc cccgcagtcg gcggcgcccg
    20941 tcgacgcggt cgcgctcggt ctggacgccg tcgccgggat gttcgccgac cggcgtgaat
    21001 tcgcgggcaa gcgacacgcg gtgatcacgg cgcacacgga cctcatggaa cgcgagctga
    21061 ccaaactcgc ctcgctgtcg gctgcgctcg ccgacacgct gcgccaccgc ggtgtggggg
    21121 agccggccgc gagcctggcc gccgaggtgg gcgtcgccgt cttcaagatc gccttcgagc
    21181 gctggatcgt gcacggtgag gaacgcacgt tgagggacct ggtcagggac tcgctcgccg
    21241 agctgaaagc cgtggcctcg ggcgaccgga cgcacggatg agccgtgccc gaccgtatcg
    21301 gcgccaccgt cggacctgga cggcggcacc gacccgcggg ctcaccggca gcaggtgctg
    21361 acgcccggac gccaggcgcg ggcaagcccc gcgaagccgc cgtcggcgag gatgccgccg
    21421 ctgagcctgc ctccgccgcg cgccacctgg ccggtcctgg acgcggctgc ttgagccgtc
    21481 ccgggccgtc tcggccggcc gacggccggt cctgagggca gtggggcctc ggccgtacgg
    21541 gcggcgcccg cgcggatagc gccgaggaac cggcggtcac cgccgcgccg ggcgaacacc
    21601 gccacctgcc cggggcggcc ggcacgcagg cggaagtcgt cccgggccgc ggggacctgg
    21661 cggcgcgtac gaccacaccg agccgggcgc ccgccgcagt cgcgaacgac ggtccggggt
    21721 cctgtgcagg tgcgccctgc ggtccgggcg cctgccggac ctagtccggt atcgctcctc
    21781 gagcggccgg tccgtacggc tcggcaggcg caacccccgt gacggatcgg cccgttcgcc
    21841 gatgacgccg acgggcgacg gctcgatgac cgtacggccg tcacgggcca ccggaaagga
    21901 cggccctcct tccacgcgac ggcagggact acggcaggcc ccacgccggg cccggctcgc
    21961 tgagggccac gggtgcgatg acgaggtcgg ggcgggagcc ggagtggacc agcacctcgc
    22021 ggcccttggg caggccgatg gcgagggtgc cgtcgccgag gtcctgggtg tgggcgggag
    22081 tcccgtcgtc cagttctgcc gtgacggtcc cgccgaggcc gtgccgcagc ttgaggggct
    22141 cgcccgccag gctcttgacc cggatgaacc gggtgacccc ggccgccctg acggcgctga
    22201 ccagaaaggc gccctgcgta cggaagttgt gcagggtcac gtccgcccac gcggacggca
    22261 cggccgggaa gacgcggacg atgccgcccc agctctggca gaacatgtcg tgcagggact
    22321 gcgaggcgga cagcggtgtc tcgatgaccg ggcccgcctc cgtgtagtgc gtgttggcgc
    22381 ggcagggata gcgggtggtg ggatcgaaga acttccgcag gtacgcgatc gcggtgtcgc
    22441 cgtctcccgt catcgcgtac atcgaggccg cgccggtgta gctgtaaccc cggtgggcgc
    22501 cggtcagcgc gtgccagtgc gccaccgact tggtgatcag gtcgcggctc tcgggctggt
    22561 cccagttgac gaggtacagc gggtacacca tcagcaggtg cgagtagtgc cggtgggact
    22621 gcgcgtaggg ggttgcggca ccgatcatga agccgttgtc gtcgaccggg tacggtgtga
    22681 gcctggccag cacctcctgc cagcgcggga ccaactcgtc cttgatgccg agcagtcggg
    22741 ccgagtcgat gagggtctga cagccccagc ggatcagtgc caggtcgtag ttggtgtcct
    22801 ggggcggtac gacgggatac tcgggggaga gggtgctcgg caggtgcagc ttgccgtcgc
    22861 tgccgggagc gaggaagtgc aggtagtagc cgatcgcccg gcgcagcacc ggatagatcg
    22921 tgtcgcgcag cagggacgtg tccatcgagt gccggtacga cagccacacg ttgtgcagcg
    22981 cccaggtgag gtcgccggtc tcggcgccgg tgcccggctg ccccacctcg cgctcggcga
    23041 acatgtctga gctgcggccg atgccggagc tgtccgtgcg gtaggcggcg ggcacgttgg
    23101 cggcaagctg ttcctggttc tgccgcaacg tggtggcgag cgcgtcgagt tcggggtggt
    23161 tgaagccctg gatgagccag tactccagct ggacgttgag gttccaccac accgcgggcc
    23221 acggggtggg ctccagccag gggccggagg tggccatcac ggggccgccc gcgcggctgg
    23281 ccgaggcgac cttgtagagc tggatccagt ggaaactctg cagccgctgg tcggggaacg
    23341 acacgaagct cttccggtag aacgcgtgcc accactgcgt gtgccgtcgc cggagcacgc
    23401 cgtacgacgg ggcgcgccgg aggttgcgca gcgagtcggc ctcggcggcc gtgccggacg
    23461 ggaagctgtg tccgacgctg agcaggaggt cgtcaccgag gcggcggtac gaggtcgcgg
    23521 tctgcccgcc gccggtcagg ggctgcagca cctgcgcggt gccgtcggcc gtgctccgcg
    23581 tggtccaggg cgggttggcg gtgtaaccgg tgggcggggc ctcgctgatg tgccgggggc
    23641 tcagcgcctc ctcggggtgg aaggtccagg tgaccttctc gccgccggtg gccgtcacgc
    23701 gggcggccag gacctcgtcg tggatgaggg cggcgagggt gagcgtgccg gcggtcgtgg
    23761 tgacggtgcc ggtcagctcg gcgtcgaaca ggctcaggcg ccagtcgacg gcggtgatgg
    23821 tgccgaccgg atcgagcgtc agatgcccta ccggcagccg gcaggtgccc cagccgctgc
    23881 cgaactcggg ccggtggtcc tggacccggc cgtgctgcac ggtgaaacgg atccggttgg
    23941 cgccgggttc ctggtagacc atgctgccga gcagcccgtc cccgaggaac gggccttcgt
    24001 accagagcgt cggcagcttg gtccacagca ggtcctggcc gcgcaggaag cgctgccacg
    24061 agccgtcggt ggtcatggtg tcgcgcagtc gccagggacg ccccgcgacc gcggacgctc
    24121 ccgactgcac cgactgcacc gactgcaccg agtgaatcgg ctggccggcg tgggcggttc
    24181 cggggagtgc cgccaccgcc gctccgccga gtgcggtgcc gagcacggat ctgcggggga
    24241 ctggtgagcg cttctccggc tgtgaggtca tcgtcgctct ccaaacctga cggatcatcg
    24301 aaacatcggg tgtatcgggg aacgtaagaa tgttctgagt gcctgtcaat gacttggacg
    24361 aagactgctt tcaaacacct ccgatgtatc cctgggactg tcggctccga gcagccgaca
    24421 ttcgtgcgca gcagcccggc ccgcgcgctg gtccacctgg aggagcccgg gtgtccacgg
    24481 cgccgcggcg acccggcgga acggagcgac cagctcgccg aactcaccga caggggcgtg
    24541 gagttggcca aggcggggca gcggccgctt ggcggtccgg taacgatctg tcgatgaccg
    24601 gatcgtatct ccgtggaatg tacatacgat ccggagtatg aacagagccg tgaagatcgg
    24661 cctcgccggt acatgcaccg ccctgctcgc tctcggggga atcggtacct acaacctggt
    24721 ccaaggcctg acctcaggtt ccgcgggtga cgtcaagccc tcggcgggga gcaccttcga
    24781 cgcgtcggag ctgtcgagca cgccaccgtc gggcgccgag gcggtgaagc tggcccgcgc
    24841 gttcctggac agctggtccc ggcagcactt cgagggcgcg gcgagcgaca ccgacgtgcc
    24901 ggacatcgcc gttcaggcgc tgcgggacta caccggcggc ctgcacctga agaagctgtc
    24961 gttcggtcac atcctctccg cagggccgtc ggcggtgacg ccgggcgcca cgaaggtcac
    25021 cttcgacgtc accgcccagg tggcgggcgg tacctggacc tactccagcg cggtcgcggt
    25081 gctcaaaggc gcgcacggcc cgctggcggt gcactggaac aactcggtgc tctatccggg
    25141 catgagcgac gggcagtcgc tgatcgcggg caagctgccc gcggacccgg gcgcggtgaa
    25201 ggtggtcgcc gccgacggca cgaccgatct gtccgcgttc ccgtccctgc aggacatcac
    25261 ggcgacgatc cgccagaacg cccagcccac gggcggtggc gccgacaccg gtgtggcggt
    25321 ggtggacggc ggcggcgcgg ccgtgcagac gctgcaggtc ttcaccaagg gacgggctcc
    25381 ggtgatccgg acgaccatcg acgccggact ccagacggtg gccgagagcg cggtgaagga
    25441 cgccc
//
