LOCUS       NZ_CP047020            22077 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces broussonetiae strain T44 chromosome.
ACCESSION   NZ_CP047020
VERSION     NZ_CP047020.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces broussonetiae
  ORGANISM  Streptomyces broussonetiae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9735779)
  AUTHORS   Mo,P.
  TITLE     Streptomyces sp. strain T44 isolated from rhizosphere soil of
            Broussonetia papyrifera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9735779)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2019) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-OCT-2019
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 12.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009796285.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 17:56:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,022
            CDSs (total)                      :: 8,931
            Genes (coding)                    :: 8,515
            CDSs (with protein)               :: 8,515
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 416
            CDSs (without protein)            :: 416
            Pseudo Genes (ambiguous residues) :: 0 of 416
            Pseudo Genes (frameshifted)       :: 171 of 416
            Pseudo Genes (incomplete)         :: 334 of 416
            Pseudo Genes (internal stop)      :: 29 of 416
            Pseudo Genes (multiple problems)  :: 110 of 416
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:31:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7558377
            Orig. end                         :: 7580454
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047020.1.
            Bacteria and source DNA available from Zhao YL.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22077
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="26"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22077
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22077
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12077](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12077
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(114..127)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            370..675
                     /locus_tag="GQF42_RS34725"
                     /old_locus_tag="GQF42_34725"
     CDS             370..675
                     /EC_number="4.2.1.96"
                     /GO_function="GO:0008124 -
                     4-alpha-hydroxytetrahydrobiopterin dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006729 - tetrahydrobiopterin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972439.1"
                     /locus_tag="GQF42_RS34725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34725"
                     /product="4a-hydroxytetrahydrobiopterin dehydratase"
                     /protein_id="WP_158926593.1"
                     /transl_table=11
                     /translation="MAVEPLSQKEIEDRLAELPGWSVEEGRLTRSYRLGSHVAAAAFVM
                     HIAAVQDELDHHSDLTLGYHTVLLSVHTHSAGGALTEKDFGLARRVEDVAPGHGAH"
     gene            681..1466
                     /locus_tag="GQF42_RS34730"
                     /old_locus_tag="GQF42_34730"
     CDS             681..1466
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (25-134). E-value: 4.6e-12. Score:
                     36.6. Matches aSDomain: nrpspksdomains_GQF42_RS34730_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676043.1"
                     /locus_tag="GQF42_RS34730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34730"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_158926595.1"
                     /transl_table=11
                     /translation="MLDYDKEADAYDASRGGEARAHAATEALLDLIPEGPGRLLDVACG
                     TGIVTRRLAARRPALRVTGADLATAMVRRAGARLPGAIVRADSRRLPFPTGGFDAVISI
                     WLLHLLDDAEDARAVVAECARVLRPGGIYVTTVDKAAAHDVGSDIDSVLASRPRRPAQD
                     AAATVTAHAARHGLEPAGATSFRGVGQGRSPRATIADLRRGWFTQLAPDGPRTEEFATR
                     LAGLPDQDRPRPDPVFEVRAYRKPTTDRLPHLPCEPRKP"
     aSDomain        756..1082
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GQF42_RS34730_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="4.60E-12"
                     /label="GQF42_RS34730_oMT.1"
                     /locus_tag="GQF42_RS34730"
                     /protein_end="134"
                     /protein_start="25"
                     /score="36.6"
                     /tool="antismash"
                     /translation="EALLDLIPEGPGRLLDVACGTGIVTRRLAARRPALRVTGADLATA
                     MVRRAGARLPGAIVRADSRRLPFPTGGFDAVISIWLLHLLDDAEDARAVVAECARVLRP
                     GGIYV"
     misc_feature    complement(1561..1575)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    1562..1576
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     misc_feature    1705..1719
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.55"
                     /tool="antismash"
     gene            1767..3239
                     /locus_tag="GQF42_RS34735"
                     /old_locus_tag="GQF42_34735"
     CDS             1767..3239
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019985189.1"
                     /locus_tag="GQF42_RS34735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34735"
                     /product="cellulose binding domain-containing protein"
                     /protein_id="WP_158926597.1"
                     /transl_table=11
                     /translation="MRHPPRSVLLSTAGAGALIAGALVPVVSAQGATPACTVEYSVTNQ
                     WAGGFQGSVTITNNASALSSWRLAFDFADGQQVTRGWNATWSQSGATVTAANESYNGSL
                     GSGARVTTNFLGSWAGSNAAPTAFTLNGTTCALDGEPPPTPPASPPSSGTAPALHVSGT
                     GLVDASGTAHRLLGVNRSGGEFMCVQGHGIWDGPVDDTAIQAIADWKADAVRIPLNEEC
                     WLGLSGIKPEYGGAAYISAVKDLVTRVEAHGLTPVLDLHWSYGQYTGNSAGCSDIHATC
                     QKPMPDAQYSPSFWASVANTFKDDPAPVFDLFNEPYPDRATTDPADAWRCWRDGGTCPG
                     ISYEVAGMQDLVDSVRGTGSRNVIMVGGLAYANDLSRWTAYKPTAPAGNLAASYHGYNF
                     NACASESCWNSTLAPVADQVPLIAGEIGENTCAHGFVDQAMKWFDAHNLSYLGWTWNTW
                     DCSSGPSLISAYDGTPTAYGTGLRDHLRALNP"
     gene            3268..4992
                     /locus_tag="GQF42_RS34740"
                     /old_locus_tag="GQF42_34740"
     CDS             3268..4992
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676052.1"
                     /locus_tag="GQF42_RS34740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34740"
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_158926599.1"
                     /transl_table=11
                     /translation="MSRNRTSLLAALALVAGTMGTALLQTPAGAATDAVPCTVGYTVQN
                     QWDTGFTAAVTITNNAAAKSSWLLRWSYAGDQKVTSGWNAGISQSGSDVTAANESYNGA
                     LANGGSVSFGFNGSYTGTNAVPAVFTLDGVACNVDDGSGGGGGTGGGTGGPTDGRVDNP
                     YAGAKVYVNPEWSARAAAEPGGSRVSSRPTAVWLDRIATIDGVNGAMGLRDHLDAALRQ
                     KGSGDLVVQLVVYDLPGRDCAALASNGELGPDDIDKYKSDYIDPIASILADPAYASLRI
                     ATIIEPDSLPNLVTNGGGTDTSTAACETMKSNGNYEKGVSYALQKLGAIPNVYNYVDAA
                     HHGWLGWDTNLGPAVQEFHKVATTNGADVHDVAGFIVNTANYSATTEPYLKVGDTVNGT
                     SVRQSKWVDWDQYVDEQSYALALRSQLVSAGFDSGIGMLIDTSRNGWGGTARPTGPGPL
                     TSVDDYVNGSRTDRRIHVGNWCNQSGAGLGERPTAAPAAGVDAYVWAKPPGESDGSSTA
                     IANDEGKGFDRMCDPTYGGNARNGNNPTGALANAPLAGHWFSAQFQQLMQNAYPPLS"
     misc_feature    5120..5129
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     gene            5225..6160
                     /locus_tag="GQF42_RS34745"
                     /old_locus_tag="GQF42_34745"
     CDS             5225..6160
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004980962.1"
                     /locus_tag="GQF42_RS34745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34745"
                     /product="trans-aconitate 2-methyltransferase"
                     /protein_id="WP_158926601.1"
                     /transl_table=11
                     /translation="MAYDHHDDHGHPAHHSHSHTQPHSHGQGHGDDVDWAAMASLLETE
                     AEAHTPAYERALAWLGEEVAEPGLIVDAGSGPGVIACLLAQTFPGARVVAADGSARLLE
                     RARARADRQGAADRFDTITGELPDSLQELEYPADLLWASRSLHHLGDQKAALTAFAARL
                     APGGTLAILEGGLAARYLPRDLGFGRPGLQTRLDAAQEDRFATMRAQLPGSVAETEDWP
                     ALLAAAGLKHTGTRSFLLDIPAPVPERARAFVVTALTRARDGYAGALDAEDRATLDRLL
                     DPADPGSVHRRPDVFLLAAHTVHRAVRPVA"
     gene            6276..6977
                     /locus_tag="GQF42_RS34750"
                     /old_locus_tag="GQF42_34750"
     CDS             6276..6977
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-168). E-value: 3e-11. Score:
                     35.5. Matches aSDomain:
                     nrpspksdomains_GQF42_RS34750_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922768.1"
                     /locus_tag="GQF42_RS34750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34750"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_158926603.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.8e-05,
                     bitscore: 23.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDSPVALITGGATGIGAAVARQLLAAGHRVTVTGRSEARLRDFA
                     DGLGRPEELLTVAGDAAVFDDVQNAVGRTLKAYGRLDTVVANAGFATHDTVAEGDPAGW
                     TEMVLTNVLGPALLVRASVEALKETRGRIVLVGSVAGFVNTPGNLYGATKWAVTGLAEN
                     TRRQVTEFGIGVTLVAPGRVETPFWDGNGSLPPGRLLSADQMADSVLWAIRQPAGVDVN
                     TVVVRPLGQPN"
     aSDomain        6291..6779
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GQF42_RS34750_PKS_KR.1"
                     /evalue="3.00E-11"
                     /label="GQF42_RS34750_PKS_KR.1"
                     /locus_tag="GQF42_RS34750"
                     /protein_end="168"
                     /protein_start="5"
                     /score="35.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGGATGIGAAVARQLLAAGHRVTVTGRSEARLRDFADGLGR
                     PEELLTVAGDAAVFDDVQNAVGRTLKAYGRLDTVVANAGFATHDTVAEGDPAGWTEMVL
                     TNVLGPALLVRASVEALKETRGRIVLVGSVAGFVNTPGNLYGATKWAVTGLAENTRRQV
                     "
     CDS_motif       6297..6386
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GQF42_RS34750_0001"
                     /evalue="1.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="GQF42_RS34750"
                     /protein_end="37"
                     /protein_start="7"
                     /score="17.7"
                     /tool="antismash"
                     /translation="LITGGATGIGAAVARQLLAAGHRVTVTGRS"
     gene            complement(6991..7698)
                     /locus_tag="GQF42_RS34755"
                     /old_locus_tag="GQF42_34755"
     CDS             complement(6991..7698)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073097.1"
                     /locus_tag="GQF42_RS34755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34755"
                     /product="glycoside hydrolase family 75 protein"
                     /protein_id="WP_158930918.1"
                     /transl_table=11
                     /translation="MRLRTLTLAAASGAALLAAGVLPAHASAVPSPRSGPASAQEGSVS
                     AADLLAKVKSCSQISNGKYKTDDETSATVPVCGKNGAVFWKADMDIDCDGQRTTNCNED
                     RDPWYQDDTAFHQSDGKPLKAESLPYVVVPSSSSIWNYSSAGIKGGGVVAVIYNNKVEY
                     AVVGDTGPTKIIGEASYATAKALGIDPDPATGGADSGVTYILFKNSKVSPIESHSAAVS
                     LGDQLAKQFLANN"
     misc_feature    7857..7877
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.74"
                     /tool="antismash"
     gene            7924..8538
                     /locus_tag="GQF42_RS34760"
                     /old_locus_tag="GQF42_34760"
     CDS             7924..8538
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676057.1"
                     /locus_tag="GQF42_RS34760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34760"
                     /product="hypothetical protein"
                     /protein_id="WP_233273556.1"
                     /transl_table=11
                     /translation="MLFVRTVYATGDPAQLGTAIRVLNTQGHDLLEERPGFRGAGVFVD
                     RALGTLLSVSWWESVEARDNSDEVMRERRPALLHPFAGTVAVENYEATVFPVGHRPLTG
                     GGMRLTRLEFAPADADLVADTFHGGVLPRLEVLPGFAGAALFLDRERGRGMTGVLFADQ
                     HALVASRSRQAAVRREGVAKAHVAVVALEEFEIVHADVRAD"
     gene            complement(8684..9520)
                     /locus_tag="GQF42_RS34765"
                     /old_locus_tag="GQF42_34765"
     CDS             complement(8684..9520)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191514.1"
                     /locus_tag="GQF42_RS34765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34765"
                     /product="aldo/keto reductase"
                     /protein_id="WP_158926605.1"
                     /transl_table=11
                     /translation="MSSKVPPIILNNGIEMPQLGYGVWQVPDDEAERAVATALEAGYRS
                     IDTAAIYGNEVGTGKAIAAAGLPREDVFVTTKLWNSDQGYDSTLRAFDASLEKLGLDYV
                     DLYLIHWPLPARGTYVDTYKALERLYADKRVRAIGVSNFLPEHLRRLIEATSVIPAVNQ
                     IELHPHLQQHTAREFHAEQGIATEAWSPLGQGKGLLDVPAIVAIAQKHGRTPAQVVLRW
                     HVQLGNIVIPKSVTPSRIKENIDVFGFSLDEEDLGAISALNEDRRIGPDPATFDLG"
     misc_feature    9583..9598
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.46"
                     /tool="antismash"
     misc_feature    9743..9758
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            9837..10004
                     /locus_tag="GQF42_RS34770"
                     /old_locus_tag="GQF42_34770"
     CDS             9837..10004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056906.1"
                     /locus_tag="GQF42_RS34770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34770"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_158926607.1"
                     /transl_table=11
                     /translation="MNESLSLPARTDDATPKTSDEKVWRSPGYRVVETALEVTAYALAD
                     RRRPAAPLAA"
     misc_feature    9840..9855
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.52"
                     /tool="antismash"
     gene            10001..10726
                     /gene="pqqC"
                     /locus_tag="GQF42_RS34775"
                     /old_locus_tag="GQF42_34775"
     CDS             10001..10726
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559516.1"
                     /locus_tag="GQF42_RS34775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34775"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_158926609.1"
                     /sec_met_domain="TIGR02111 (E-value: 6.7e-82, bitscore:
                     273.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPADLDGRAAWPAAEFTGRLRAVTALRYHDRHPFNQRMHRGE
                     LTRAELRRWIAARFHYQRHIPVKDALILAGLDRPEERRAWLRRIHDQDGTDADSREGGG
                     IERWLRLGEAAGLARADLLDTSRVPPGVRFAVEAYVTFCRRRPVLEAVAASLTELSAPD
                     LMRTRIAAFERHYPWIDPAGLAYFRARVTQGARDAEQALALVLARARTREEQQRAVAAL
                     EFKCEVLWALLDAVDRSEP"
     gene            10723..11004
                     /gene="pqqD"
                     /locus_tag="GQF42_RS34780"
                     /old_locus_tag="GQF42_34780"
     CDS             10723..11004
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174693.1"
                     /locus_tag="GQF42_RS34780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34780"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_233273557.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.8e-18, bitscore:
                     65.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.4e-10, bitscore: 39.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPAPPATTWRAVLARGVVLRHDRVRGADLLLLPERVVLLDGS
                     AGEVLRLCDGVRDVAAVVAELTVRHPAAPVAAEAAAFLERLREEGWLR"
     aSDomain        10759..10998
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GQF42_RS34780_PqqD_RRE.1"
                     /evalue="5.60E-21"
                     /identifier="RREFam006.1"
                     /label="GQF42_RS34780"
                     /locus_tag="GQF42_RS34780"
                     /protein_end="92"
                     /protein_start="12"
                     /score="65.1"
                     /tool="antismash"
                     /translation="RAVLARGVVLRHDRVRGADLLLLPERVVLLDGSAGEVLRLCDGVR
                     DVAAVVAELTVRHPAAPVAAEAAAFLERLREEGWL"
     gene            11001..12077
                     /gene="pqqE"
                     /locus_tag="GQF42_RS34785"
                     /old_locus_tag="GQF42_34785"
     CDS             11001..12077
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669244.1"
                     /locus_tag="GQF42_RS34785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34785"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_158926613.1"
                     /sec_met_domain="PF04055 (E-value: 1.9e-19, bitscore: 69.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.9e-06, bitscore: 26.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.5e-08, bitscore:
                     33.9, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPAPPWALLAELTHACPLRCGYCSNPVELVSRSAELSTAQRSDV
                     FRQAGALGVVHTHLSGGEPLLRRDLPALVAAADGAGLYTQLVTSGVGLGERRLAELIRA
                     GLRSVQLSVQHADPLAAEHIAGARSFTAKQRAARLVRAAGLPLGLNAVLHRGNLDALDG
                     LIRLALDWGADRIELAHTQYHGWAARNRAALMPTPAQVGRARDRVAHWRERLADTLELV
                     WVAPDLVDATAKPCMGGWGAVSLTVTPDGTVLPCPAAGTLPALDPPRVQDHELDWIWRE
                     SKAFNAFRGEAWMPDPCRGCALRTTDHGGCRCQAHALTGDPTRTDPACRHAPDHHLVRA
                     LVHDPAEPPAFAYREGGS"
     gene            12250..13449
                     /locus_tag="GQF42_RS34790"
                     /old_locus_tag="GQF42_34790"
     CDS             12250..13449
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119200.1"
                     /locus_tag="GQF42_RS34790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34790"
                     /product="glycoside hydrolase family 105 protein"
                     /protein_id="WP_158926616.1"
                     /transl_table=11
                     /translation="MRRRRLRAALIAAALATATLATLPAALPPAAAAPAAASRPGAARD
                     WSTAVVDSTTARFTPATIGGWSYPVGLYLYGQYLVYRRTHDPRLLSYIKAYVDRFVGSD
                     GTIGQSFDSLDSMQAGRLLVILHHETGQDRYAQAARKIRDRLNSYPRTSDGGFWHADTS
                     SRAHQLWADGAYMVNPFLVEYGREFHDSAYTDAEAARQLYVYGRHLQVANGLLRHAYDE
                     SKSASWADPATGLAPEHWCRAVGWYAMALTDVLDAIPADQRYRPQLLGMFRALAAALEK
                     YQDPASGRWFQVIDKGARPDNWTETSCSSMFAYALDRGAQQGYLDPHFRSVARRGGQGV
                     LARLSVGADGRTDLTDISVGTNVGTYAYYVGRPRAVNDFHGLGAFLIMNEQLHDDGGMA
                     "
     gene            13446..13730
                     /locus_tag="GQF42_RS47775"
     CDS             13446..13730
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119201.1"
                     /locus_tag="GQF42_RS47775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_407699509.1"
                     /transl_table=11
                     /translation="MNASRRVVPGPPGAASWRLKWSPSARTDGLGAFETVGDDRAHSHP
                     AGHPHICASGDDWRFTTHTADRVRPKWGIRSSLGDTYLLLTDLRGYQLA"
     gene            13743..16994
                     /locus_tag="GQF42_RS34800"
                     /old_locus_tag="GQF42_34800"
     CDS             13743..16994
                     /GO_function="GO:0004650 - polygalacturonase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141318.1"
                     /locus_tag="GQF42_RS34800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34800"
                     /product="glycosyl hydrolase family 28 protein"
                     /protein_id="WP_233273558.1"
                     /transl_table=11
                     /translation="MTSHIAGPGRAAAFILCTLAVVLGLAHPAALAAPHPTASRPTAGY
                     DVRDYGAKGDGSANDTPAIDKAVTAAATAGGGTVRFPPGTYKSANTIHMKSHVTLQLDK
                     GATIRGSSARTYDPPEPNAYDKYQDFGHSHFHDAMIYGDRLTDIGFTGEGVIDGGGDLI
                     TGNPRSGQADKILSLTRCDGLRLGDGLTLRRGGHFAALINGCTNVVSDSLTIDTAGDRD
                     GWNVISTTNVTITGAHISANDDALVFKSDYALGATLPSGHVRVSDAVLSARCCNALMFG
                     SETCGDFSDYQFEKIRIEGADKSGLGMVSMDGAKISDVHYRDITMTHVHSPIMEKIGTR
                     GRCGNSPGVGSISDVTYDHITATGNSPSFSPTLWGENGHRISGITFTNVDITVPGGNGT
                     LSTGVPGNDPNDYNPKSIGTRPAYGWYLHNADDIRFTDSAVRYAADDGRPAVIANAASG
                     IRLTRFTAQEGSRSPHDIGLQNVTGYCLADSHTTTGGALRVSASGSSEDCGTPARPLDL
                     ENPRQAFLRASVGGLFLHWGLRTAPAHTSCTAWEKDVTNGGWTPQYWVNEAGKLHTQYL
                     VLATFHSRLGYARPWPSKIPGSCSTKRDFLGELINAAKAKGMKVILYMTDDPQWHDDGG
                     HEWLDSAAYSAYKGKNVDLTTRDGFGEFSYDNFFEVMNRYPDLGGFWIDNDNAYWESHH
                     LYEQIYQKRPNYTLSNNNEDTPIMDMISNEQKTGMTPAYDYPQAVYTAQPRLTEADFKL
                     PSTGAWWYDGSDPTVDRGLTLGRLISNAGSSVKALMAETAEVNGQFPPNQAAFNTFADS
                     YLDPIWESLHGTEGGGYMYGGLAPGGWNDGAHGVTTIAKDDPDRQYIHVLTPPSTSTLR
                     VRDNGYRIASVTNLRTGKPVSWSQSGGVLTLTGLGGWDPYDTVLKVITAGRQGIATGVT
                     VTASASASGHAASAAGDGDHLTYWDNDKTLPVTLTFDLGAAKQVRYLGLNQREDSVAYA
                     RSATEQSARIKAYQVFLSTDGTHWTKAATTGQLPSTRGVQTIDLTAATARYVRLEADST
                     WAAATDTTRYRRLRIDEAWIGTSYATPAVPGGRRP"
     gene            16991..18358
                     /locus_tag="GQF42_RS34805"
                     /old_locus_tag="GQF42_34805"
     CDS             16991..18358
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993881.1"
                     /locus_tag="GQF42_RS34805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34805"
                     /product="glycoside hydrolase family 27 protein"
                     /protein_id="WP_158926618.1"
                     /transl_table=11
                     /translation="MTRLRTATAAAAGLLVATAIPLMATPHRAAASDNGRAVRPAMGWS
                     SWSYVRRQPTEAAIEAQADALVSSGLARHGFVQVNLDDFWQKCDANGFQVDGYGRWSPD
                     PAKFPDGIKSLADHVHAKGLKFGFYVTPGIARNAVLKNTPVEGTTYHAKDIADTSKTEK
                     NYNCKNMYALDYARPGAQEFVDSWARQFASWGVDYLKIDGVGGQDIPDVQAWDKALRAT
                     GRPITFALSNNLPIDQATTWRTLANSWRTQGDVECYCGPGPSGSGYPLTDWAHVARRFD
                     SAAAWQPYAGPGGWNDLDSLEIGNGDRAGLDADQRRSQFTLWSMAAAPLLLGTDLTRLD
                     PVDRAMLTNDRLIGVDQDGIAAQRVVNSGAGQVWSKRESNGDRVVALFNTGTSGSATVT
                     VDWSRIGLTGSGDVTDLWSGAHKGTVAGSYSAALRPGETRLIRVRPVDSRGTAVDR"
     gene            18486..20516
                     /locus_tag="GQF42_RS34810"
                     /old_locus_tag="GQF42_34810"
     CDS             18486..20516
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141320.1"
                     /locus_tag="GQF42_RS34810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GQF42_34810"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_158926620.1"
                     /transl_table=11
                     /translation="MKTSRVLPYGLAAVLALPLAGLSQGTAHAATDYQAEDATISQGTV
                     AGNHTGYTGTGFVDYTNVKGSYVEFRVSAAATGPASVTLRYANGTAADRPMDLSVNGTV
                     VAPAVSFPATADWNTWAAKAVNVTLKAGTNTIRATATTANGGPNLDRISLAAVTDTQAP
                     TRPGQPSCPDIGEDRLTLAWGASTDDTGVAAYDLYEHGNKIGEAPGDTTTKTLTGLAPN
                     TTYDLTVIARDAAGNTSPASPVVDCTTKPSSDTTPPTAPGALHTADITSNTVGLTWGAA
                     TDDRGVTAYDIRSGTTVYRTVTGGTSATLTGLACNSPYSLDVVARDAAGNVSPPSNTVT
                     FTTKACATDGGVPSSIATLSTGWTIPWGTYWMPDGKTALVTERDDFRVWKVTKDGTRTQ
                     VGTVPNAVTTNGEGGLLGVAVDPEWATNHYVYFMHTAAEGNRVVRMTYDGSTLTGYKIL
                     LQGIRKNRYHNGGRLAFGPDGYLYVSTGEAQQPDLAQDKNSLNGKILRMTTDGKPAPGN
                     PFGNYVYSLGHRNPQGLAFDRNGRLWEAEFGNSSKDELNLIKPGANYGWPTCEGTCSVA
                     GMTNPKATWNVSEASPSGIAIVRNVIYMASLRGERLWRIPVNGDTESVGTPTAYYVGSY
                     GRLRTVTKVPGADELWLSTTNCDNNGGAADGSDQIFRVTIK"
     misc_feature    20680..20694
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
ORIGIN
        1 gggtcgccga ggaggccctc gccatcggtg tgtacggcgc gctcgccgag ccccgccccg
       61 aacaggcgct gctgctggcc gtcaaccact cgggcgacag cgactccacc ggctcgatct
      121 gcggcaacct cctcggcacg ctgcacggcg acaccggtct gccgcacgac tgggtggccc
      181 gggtggaggg ccggtaccgc atcgccgcgc tcgccgacga cctggcggcc gagtacgcac
      241 gcggctgacg gcgccttcac ggcggagtag gcgcgcggcc ggcgtggcag gctgaacgtg
      301 gacctgcacc tgcacctgat ccgaaatccg aaccccgccg tcccgccgcc ccgaagggag
      361 ccgaaggcca tggccgtgga accgctgtcg cagaaggaga tcgaggaccg gctggcggag
      421 ctgccgggct ggtcggtgga ggagggccgg ctgacccgct cctaccggct cggctcgcat
      481 gtcgcggcgg cggcgttcgt catgcacatc gccgccgtcc aggacgagct ggaccaccac
      541 tccgacctca ccctcggcta ccacaccgtc cttctcagcg tgcacacgca cagcgcgggc
      601 ggcgccctca ccgagaagga cttcggtctc gcccgcaggg tggaggacgt cgccccaggt
      661 cacggcgcac actgacaggc gtgctcgatt acgacaagga agccgacgcc tacgacgcgt
      721 cccgcggcgg cgaggctcgc gcccacgccg ccaccgaagc cctgctcgac ctgatccccg
      781 aggggccggg ccggctgctc gacgtggcct gtggcaccgg catcgtcact cggcggctgg
      841 ccgcccgccg ccccgcgctg cgggtgaccg gcgccgacct cgccactgcc atggtccgcc
      901 gggcgggggc gaggctgccg ggcgcgatcg tccgcgccga cagccgccgc ctgccctttc
      961 ccaccggcgg attcgacgcc gtcatcagca tctggctgct gcacctgctg gacgacgccg
     1021 aggacgcccg cgccgtcgtc gccgagtgcg cccgggtgct gaggcccggc gggatctacg
     1081 tcaccaccgt cgacaaggcc gccgcgcacg acgtcggcag cgacatcgac tccgtcctcg
     1141 cctcccgccc gcgccgcccc gcccaggacg ccgccgccac cgtcaccgcg cacgccgccc
     1201 ggcacgggct ggaaccggcc ggcgccacca gcttccgcgg cgtcgggcag ggccgcagcc
     1261 cccgcgccac catcgccgat ctgcgccgcg gctggttcac ccagctggcg ccggacgggc
     1321 cgcgcaccga ggagttcgcg acgcgcctcg cgggccttcc ggaccaggac cgcccacggc
     1381 cggacccggt gttcgaggtg cgtgcctacc gcaagccgac cacggaccga ctcccacacc
     1441 ttccgtgcga gccgcggaaa ccgtgaacgc gacggccggg cggtcccctg tgtcgtgggg
     1501 accgcccgtc gcggtacagg ggccagtggc ggggcgactg cccgggcccg gaaccaacca
     1561 gtgggagcgc tcccatagtg gagacggccc ggtgcgcggt caaggtgctc gaagagtcga
     1621 aaagattcga cggacaccct tgcggaaaag tcggcaactc ccctgggcat ccaagccact
     1681 tggcgctacc ttccttcgca ccagtgggag cggttccagt cagtcgacgc gcctgtgacg
     1741 gcgcgccaaa ctgcaaggag tcgctcatgc gacacccccc gcgttcagta ctcttgtcca
     1801 ccgccggcgc gggcgcgctc atcgcgggcg cgctcgtccc ggtggtgtcg gcccaggggg
     1861 ccacgcccgc ctgcacggtg gagtactccg tcaccaacca gtgggccggc ggcttccagg
     1921 gctcggtgac catcaccaac aacgcctcgg cactgagcag ttggcggctc gccttcgact
     1981 tcgccgacgg ccagcaggtg acccggggct ggaacgccac ctggtcccag tccggcgcca
     2041 ccgtgaccgc ggccaacgag agctacaacg gctccctcgg ctccggcgcg cgcgtgacca
     2101 ccaacttcct cggctcctgg gcgggcagca acgccgcacc gacggccttc acgctcaacg
     2161 gcacgacctg cgccctcgac ggggagcccc cgccgacccc gccggcctcc ccgccctcga
     2221 gcggcaccgc gcccgccctg cacgtctcgg gcaccgggct cgtggacgcc tccggcacgg
     2281 cgcaccggct gctcggcgtc aaccgctccg gcggcgagtt catgtgcgtg cagggccacg
     2341 gcatctggga cggaccggtg gacgacacgg cgatccaggc catcgccgac tggaaggccg
     2401 atgcggtccg catcccgctc aacgaggagt gctggctggg cctttccggc atcaagcccg
     2461 agtacggcgg cgccgcctac atcagcgccg tgaaggacct ggtgacccgc gtcgaggccc
     2521 acggcctgac gccggtcctc gacctgcact ggtcctacgg ccagtacacc ggcaactcgg
     2581 ccggctgctc cgacatccac gccacctgcc agaagccgat gcccgacgcg cagtacagcc
     2641 cgtcgttctg ggcgtcggtg gcgaacacct tcaaggacga cccggcgccg gtcttcgacc
     2701 tgttcaacga gccgtatccg gaccgggcga ccaccgaccc ggccgatgcc tggaggtgct
     2761 ggcgggacgg cgggacctgc cccgggatct cgtacgaggt cgccggcatg caggatctcg
     2821 tcgacagtgt ccgcggtacc ggatccagga acgtcatcat ggtcggcggt ctggcgtacg
     2881 cgaacgacct cagccggtgg accgcataca aacccaccgc cccggcaggc aacctcgccg
     2941 cctcctacca cggctacaac ttcaacgcct gcgcgagcga gagctgctgg aactccaccc
     3001 tcgccccggt cgcggaccag gtgcccctga tcgccggcga gatcggcgag aacacctgcg
     3061 cgcacggctt cgtcgatcag gccatgaagt ggttcgacgc ccacaacctg tcctacctcg
     3121 gctggacctg gaacacctgg gactgctcct cggggccgtc cctgatctcc gcctacgacg
     3181 gcacacccac cgcctacggc accgggctgc gcgaccacct gcgtgccctc aacccgtaac
     3241 ccgccacgga agaaggaacc cgcactgatg agccgtaaca gaacctcact gctcgcagcc
     3301 ctggcgctgg tcgccgggac catggggacg gcactgcttc agacaccggc aggtgccgcc
     3361 accgacgccg tcccctgcac cgtcggctac acggtgcaga accagtggga caccggcttc
     3421 accgccgccg tcaccatcac caacaacgct gccgccaagt cgagttggtt gctcaggtgg
     3481 agctacgccg gcgaccagaa ggtcaccagc ggctggaacg ccgggatcag ccagagcggc
     3541 agcgacgtca ccgccgccaa cgagagctac aacggcgcgc tggcgaacgg cggttcggtc
     3601 agcttcggct tcaacggcag ctacaccggc accaacgccg tgccggccgt gttcaccctc
     3661 gacggtgtcg cctgcaacgt cgacgacggc agcggcgggg gaggcggcac gggcggcgga
     3721 accggcggcc ccaccgacgg ccgcgtcgac aacccctatg ccggagccaa ggtctatgtg
     3781 aaccccgagt ggtccgcgcg ggccgccgcg gaaccgggcg gcagccgtgt ctccagccgg
     3841 cccaccgccg tctggctcga ccgcatcgcc acgatcgacg gcgtcaacgg agccatgggc
     3901 ctgcgcgacc atctcgacgc ggccctccgg cagaagggct cgggcgacct ggtcgtccag
     3961 ctggtcgtct acgacctgcc cggccgcgac tgtgccgccc tcgcctccaa cggcgaactc
     4021 ggccccgacg acatcgacaa gtacaagagc gactacatcg acccgatcgc ctcgatcctc
     4081 gccgacccgg cctacgcctc cctcaggatc gccaccatca tcgagcccga ctcgctgccg
     4141 aacctggtca ccaacggcgg cggtaccgac accagcaccg ccgcctgcga gaccatgaag
     4201 tccaacggca actacgagaa gggcgtctcc tacgccctgc agaaactcgg tgcgatcccg
     4261 aacgtctaca actacgtgga tgccgcccac cacggctggc tcggctggga caccaacctc
     4321 ggcccggccg tgcaggagtt ccacaaggtg gccaccacca acggcgccga tgtgcacgac
     4381 gtggccgggt tcatcgtcaa cacggccaac tacagcgcca ccacggagcc gtacctcaag
     4441 gtcggcgaca cggtgaacgg cacgagcgtg cgccagtcga agtgggtgga ctgggaccag
     4501 tacgtggacg agcagtccta cgccctcgcg ctgcgctccc agctggtctc ggcgggcttc
     4561 gactccggca tcggcatgct gatcgacacc tcccgcaacg gctggggcgg gaccgcccgg
     4621 cccaccggcc ccggcccgct gacgtcggtt gacgactatg tcaacggcag caggaccgac
     4681 cggcgcatcc acgtcggcaa ctggtgcaac cagagcggcg ccggtctcgg tgaacggccg
     4741 accgccgccc cggccgccgg tgtcgacgcc tatgtgtggg ccaagccgcc gggggagtcg
     4801 gacggctcca gcacagccat cgccaacgac gagggcaagg gcttcgaccg gatgtgcgac
     4861 ccgacgtacg gcggcaacgc ccgcaacggc aacaacccca ctggcgccct ggcgaacgcg
     4921 ccgctggccg ggcactggtt ctccgcccag ttccagcagc tgatgcagaa cgcctacccg
     4981 ccgctgtcgt aggcacggcg cgatgagcgt ccgccggggt cggcccgccc ctgggtcctg
     5041 gccccggcgg atcgcgcgtg caccggttcg ccgtccacga ggcctcgtcg tgctgtcacg
     5101 ggccctcacc gcgcacccac gttttttgcg gtaccggcaa tttctttgcg gcaccggcaa
     5161 cagaactggc cccctggggg agcgccgtcg cacgctggcg gcaacccaag gagaggcggc
     5221 caccatggca tacgaccacc acgacgacca cgggcacccc gcgcaccaca gtcacagcca
     5281 cacccagccc cacagccacg gtcaggggca cggggacgac gtcgactggg ccgccatggc
     5341 gtcgctgctg gagacggagg ccgaggcgca cacccccgcc tacgagcgcg cgctggcctg
     5401 gctgggcgag gaggtggccg aacccgggct gatcgtggac gcgggcagcg ggcccggagt
     5461 gatcgcctgc ctgctcgcgc agaccttccc cggcgcgcgg gtggtcgccg ccgacggctc
     5521 cgcccggctc ctggagcgtg cccgtgcccg ggccgaccgg cagggcgccg ccgaccgctt
     5581 cgacaccatc accggtgaac tccccgattc cctccaggag ttggagtatc cggcggatct
     5641 gctgtgggcc agccgcagcc tgcaccacct cggcgaccag aaggcggcgc tcaccgcgtt
     5701 cgccgcccgg ctcgctcccg gcggcacgct cgccatcctg gagggcggcc tggctgcccg
     5761 ctatctgccc cgcgacctgg gcttcggccg ccccggactg cagacccgtc tcgacgccgc
     5821 ccaggaggac cggttcgcga cgatgcgtgc gcagctgccc ggctcggtcg ccgagaccga
     5881 ggactggccg gccctgcttg ccgccgcggg cctgaagcac accggcaccc gcagcttcct
     5941 gctcgacatc cccgcccccg tgcccgagcg ggcccgcgct ttcgtcgtca ccgcgctcac
     6001 gcgtgcccgg gacgggtacg ccggggccct ggacgccgag gaccgcgcca ccctcgaccg
     6061 gctcctcgac cccgccgacc ccggcagtgt ccaccgccgc cccgatgtgt tcctgctggc
     6121 ggcccacacc gtgcaccggg cggtacggcc ggtggcctag cgggccgacg gcgggcgagg
     6181 gtgcggccgg ttcccgggcc gtgggcggac gcttgacctc gagcgcgctc cacgtgatga
     6241 actccccggc gtcaccgaca cacgaggggg aacccgtgaa cgactctccg gtcgcactga
     6301 tcaccggcgg cgccaccggc atcggcgccg ccgtcgcccg gcaactgctc gccgccggcc
     6361 accgggtgac cgtcaccggc cgcagcgagg cccggctgcg ggacttcgcc gacggcctcg
     6421 gccggcccga ggaactgctg acggtcgccg gtgacgcggc tgtgttcgac gatgtgcaga
     6481 atgctgtcgg ccgtacgctc aaggcgtacg gccgactgga caccgtcgtc gccaacgcag
     6541 gcttcgccac ccacgacacc gtcgccgagg gcgacccggc cggctggacc gagatggtcc
     6601 tcaccaacgt cctcggcccg gccctgctcg tccgtgcctc cgtcgaggcg ctcaaggaga
     6661 cccgcggccg gatcgtcctc gtcggcagcg tcgccggctt cgtgaacacc ccgggcaatc
     6721 tctacggggc cacgaagtgg gcggtcaccg ggctcgccga gaacactcgg cgccaggtca
     6781 cggagttcgg gatcggtgtg acgctggtcg cccccggccg ggtggagacc ccgttctggg
     6841 acggcaacgg cagcctgccc ccggggcgtc tgctgagcgc cgaccagatg gccgactcgg
     6901 tgctctgggc gatccgccag ccggccgggg tcgacgtcaa caccgtggtc gtacgtccgc
     6961 tggggcagcc caactgacgt acggcgcacg tcagttgttt gcgaggaact gcttggccag
     7021 ctggtccccg agcgagaccg cggcgctgtg gctctcgatc ggggagacct tggagttctt
     7081 gaacaggatg taggtcacgc ccgagtcggc gccaccggtg gccgggtcgg ggtcgatgcc
     7141 gagcgccttg gcggtggcgt acgacgcctc accgatgatc ttcgtggggc cggtgtcgcc
     7201 gacgacggcg tactccacct tgttgttgta gatgacggcc acgacgccgc cgcccttgat
     7261 gccggcgctg gagtagttcc agatactgct ggagctgggc accacgacgt acgggagcga
     7321 ctccgccttc agcggcttgc cgtcggactg gtggaaggcg gtgtcgtcct ggtaccaggg
     7381 gtcgcggtcc tcgttgcagt tggtggtgcg ctggccgtcg cagtcgatgt ccatgtcggc
     7441 cttccagaac accgcgccgt tcttgccgca caccgggacc gtggccgacg tctcgtcgtc
     7501 ggtcttgtac ttgccgttgg agatctgcga gcaggacttc accttggcca gcaggtcggc
     7561 ggcgctgacc gagccctcct gggccgaggc cgggccggac ctcggcgacg ggacggcgga
     7621 cgcgtgcgcg gggagcactc cggcggcgag cagggcggcc ccggaggccg cggcgagagt
     7681 cagcgttcga aggcgcactg tggggggcac gtgggggacc cttctgttag gaaagtttcc
     7741 ttaccgggtg ccgtacaccg tggacccatg tacatgtcct cgtcaagcct ccggttgcga
     7801 agtcccgaaa cctgtgcgta ttgcggtgat ttacgtacgc cgcaagactg aagaggagtt
     7861 atttctccgg atatgtctgc cgccgtcggc ccggctcggt cacggctccg ggaggtgaga
     7921 ggcatgttgt tcgtccgcac ggtgtacgcg accggcgatc cggcacagct gggcacggcg
     7981 atccgggtcc tgaacaccca ggggcacgac ctgctcgagg aacggcccgg cttcaggggc
     8041 gcgggcgtct tcgtcgaccg ggctcttggc accctgctct cggtgagctg gtgggagtcg
     8101 gtcgaggcgc gtgacaacag cgacgaggtg atgcgcgagc ggcggccggc gttgctgcat
     8161 ccgttcgccg ggaccgttgc ggtcgagaac tacgaggcca cggtcttccc cgtcgggcac
     8221 cggccgctca ccggcggcgg gatgcggctg acgcggctgg agttcgcgcc cgcggacgcg
     8281 gatctggtcg ccgacacctt ccacgggggc gtgctgcccc gcctggaggt gctgcccgga
     8341 ttcgccgggg cggcgctgtt cctggaccgc gagcgcgggc gcggcatgac cggggttctc
     8401 ttcgcggacc agcacgcgct cgtcgcgtcc cgctcacgcc aggcggccgt ccggcgcgag
     8461 ggcgtggcca aggctcatgt cgcggtcgtc gccctggagg agttcgagat cgtgcacgcg
     8521 gacgtgcggg cagactgagc cgtgcgacgt gcggcccttg cgacggagca cggccgcacg
     8581 tcccgccggc gggcggtacg ggcggccgtg gtgtccgtgg tgcgcgggtg tgcgcgatgc
     8641 cggtccgggc ccggccccgg cgtcgcggcg ggacgcggtc cgctcagccc aggtcgaagg
     8701 tggcagggtc ggggccgatg cgccggtcct cgttgagcgc gctgatcgcc ccgaggtcct
     8761 cctcgtccag gctgaagccg aagacgtcga tgttctcctt gatccgggac ggcgtcacgg
     8821 acttggggat cacgatgttg ccgagctgga cgtgccagcg cagcacgacc tgggccgggg
     8881 tacggccgtg cttctgcgcg atcgcgacga tcgccggcac gtccagcagg cccttgccct
     8941 gcccgagcgg ggaccatgcc tcggtggcga tgccctgctc cgcgtggaac tcgcgggcgg
     9001 tgtgctgctg cagatgcggg tgcagctcga tctggttgac cgccgggatg acgctggtcg
     9061 cctcgatcag ccgtcgcagg tgctcgggga ggaagttgga gacgccgatg gcgcggaccc
     9121 gcttgtcggc gtagagcctc tcgagcgcct tgtaggtgtc gacgtaggtg ccgcgggccg
     9181 gcagcggcca gtggatcagg tacaggtcga cgtagtcgag acccagcttc tcgagcgacg
     9241 cgtcgaaggc gcgcagcgtg gagtcgtatc cctggtcgct gttccagagc ttggtggtga
     9301 cgaagacatc ctcgcggggc aggccggcgg cggcgatggc cttgccggtg cccacttcgt
     9361 tgccgtagat cgccgcggtg tcgatgctgc ggtacccggc ctccagggcc gtggcgacgg
     9421 cccgctcggc ctcgtcgtcg ggcacctgcc agacgccgta gcccagctgg ggcatctcga
     9481 tgccgttgtt caggatgatc ggggggacct tgctgctcac gagccttgga tccttcggtt
     9541 gaagacaggt gctactccca tcgtcaacga tcacgatcgg tgtcgcattc ctgatcggcg
     9601 aatccggggc aactgaccgg cggatcagtt cccagggtcg agattggccg gaaatgcatc
     9661 cgacgttttc ggtccggacc attgaccgtg gagcgtcgtc ccgcgactct gtatcgcgct
     9721 accggacgtg tcgatgaacc cggtgcatac atgtgaaccg gccctgacca tggccgctgc
     9781 ctcctctctg gctccctgct gagatccctc atcctcagga aagcgagtgt gcacacatga
     9841 acgagagcct ttctctgcct gcccgtacgg acgacgccac cccgaagaca tcggatgaaa
     9901 aggtctggcg aagccctggt taccgtgtcg tggagaccgc gctggaggtg accgcctacg
     9961 cgctcgccga ccgccgtcgg cccgcggcgc ccctggccgc atgaccgccg cgccagcgga
    10021 cctcgacggc cgcgccgcct ggccggccgc cgagttcacc ggccggctgc gcgccgtcac
    10081 ggcgctgcgc taccacgacc gccacccctt caaccagcgc atgcaccgcg gcgagctgac
    10141 ccgcgccgaa ctgcgccgct ggatcgccgc ccgcttccac taccagcggc acatccccgt
    10201 caaggacgcg ctgatcctcg ccgggctcga ccggcccgag gaacgccgcg cctggctgcg
    10261 ccgcatccac gaccaggacg gcaccgacgc cgactcccgg gagggcggcg gtatcgaacg
    10321 ctggctgcgg ctcggcgagg cggccggact cgcccgcgcg gaccttttgg acacctcgcg
    10381 ggtgccgccc ggggtgcggt tcgcggtgga ggcgtacgtc accttctgcc ggcgccgtcc
    10441 ggtcctggag gccgtcgcgg cctcgctgac cgaactgtcc gccccggatc tgatgcgcac
    10501 ccgcatcgcc gccttcgaac gccactatcc ctggatcgac ccggcgggtc tcgcctactt
    10561 ccgcgcccgc gtcacccagg gcgcccggga cgccgaacag gccctcgccc tcgtcctcgc
    10621 ccgggcccgc acccgcgagg agcagcaacg ggccgtcgcc gcactggagt tcaagtgcga
    10681 ggtgctgtgg gccctgctgg acgcggtgga ccggagcgag ccgtgacagc ggcgccggcc
    10741 ccaccggcca cgacatggcg ggccgtcctg gcccggggcg tggtgctgcg ccacgaccgg
    10801 gtccgtggcg ccgacctgct gctgcttccg gagcgggtcg tgctgctcga cggcagcgcg
    10861 ggcgaggtgc tccggctgtg cgacggcgtc cgggacgtgg ccgccgtcgt cgccgagctg
    10921 acggtacggc accccgcggc acccgtggcc gccgaagcgg cggcgttcct ggaacggttg
    10981 cgcgaggagg gctggctgcg atgactccag cgcctccctg ggccctgctc gccgaactca
    11041 cccatgcctg tccgctgcgc tgcggttact gctccaaccc cgtcgaactg gtcagccggt
    11101 cagccgagtt gagtaccgca cagcggtcgg acgtcttccg gcaggcgggc gcgctcggtg
    11161 tcgtgcacac ccatctgtcc ggcggcgaac cgctcctgcg gcgcgatctg ccggccctgg
    11221 tggccgccgc cgacggagcg ggcctgtaca cccagctcgt caccagcggg gtcggactcg
    11281 gcgagcggcg gctggccgag ctgatccggg ccgggctgcg cagcgtgcag ctgtcggtgc
    11341 agcacgcgga ccccctggcc gccgaacaca tcgcgggcgc acggtcgttc acggcgaaac
    11401 aacgcgccgc ccgactggtt cgcgcggcgg gcctgcccct cgggctgaac gccgtgctgc
    11461 accgcggcaa tctggacgcc ctcgacggcc tgatccggct cgcgctcgac tggggtgccg
    11521 accggatcga actcgcccac acccagtacc acggctgggc ggcccgcaac cgcgccgccc
    11581 tgatgcccac acccgcgcag gtcggacgcg cccgcgaccg ggtggcccac tggcgtgaac
    11641 ggctcgcgga cacactggag ttggtgtggg tcgcgccgga tctggtggac gccaccgcga
    11701 aaccctgcat gggtgggtgg ggcgccgtct ccctcacggt cacccccgac ggcacggtgc
    11761 tgccctgccc ggccgccggt accctgcccg cactggaccc gccccgtgtg caggaccacg
    11821 aactggactg gatctggcgg gagtcgaagg ccttcaacgc cttccgcggc gaggcctgga
    11881 tgcccgatcc ctgccgcggc tgcgccctgc gcaccaccga ccacggcggc tgccgctgcc
    11941 aggcccacgc cctgaccggc gaccccaccc gcaccgaccc ggcctgccgg catgccccgg
    12001 accaccacct cgtccgtgcc ttggtgcacg accccgccga accgcccgcg ttcgcctacc
    12061 gagagggagg gtcatgagat gccggggcct gcgcgcggcg ccggctgccg ctgcgcttgt
    12121 caccggggtc ctggcggcgt tccccgccgc cctgctcccg cctgccgctg ccccggacca
    12181 ccacctcgtc cgtgccttgg tgcacgaccc cgccgaaccg cccgcgttcg cccaccgaga
    12241 gggagggtca tgagacgccg acgcctgcgc gcggcgctga tcgccgccgc gcttgccacc
    12301 gccaccctgg cgacacttcc cgccgccctg cccccggccg ccgccgcccc ggccgccgca
    12361 tcgcgtcccg gcgccgcccg tgactggtcc acggccgtcg tcgactccac cacggcccgc
    12421 ttcaccccgg ccaccatcgg cggctggtcg tacccggtgg gcctgtacct ctacggccag
    12481 tacctcgtct accggcgcac ccacgacccg cgcctgctgt cctacatcaa ggcctacgtc
    12541 gaccggttcg tcggcagcga cggcacgatc ggccagtcct tcgacagcct ggacagcatg
    12601 caggcgggcc ggctgctcgt gatcctgcac cacgagaccg gccaggaccg ctacgcccag
    12661 gccgcccgga agatccgcga ccgtctgaac agctatccgc gcacctccga cggcggcttc
    12721 tggcacgccg acaccagcag ccgcgcacac cagctgtggg cggacggcgc ctacatggtg
    12781 aacccgttcc tcgtcgagta cggcagggag ttccacgaca gcgcgtacac cgacgccgag
    12841 gccgcccggc agctgtatgt ctacggccgc catctccagg tcgcaaacgg cctgctccgg
    12901 cacgcctacg acgagtcgaa gtcggcgagc tgggccgatc cggccacggg gctggccccc
    12961 gagcactggt gccgcgccgt cggctggtac gccatggccc tgaccgacgt cctggacgcg
    13021 atcccggcgg accagcggta ccggccccaa ctgctcggca tgttccgcgc gttggcggcg
    13081 gcgctggaga agtaccagga cccggcgtcc gggcggtggt tccaggtgat cgacaagggt
    13141 gcgcggccgg acaactggac cgagacgtcc tgctccagca tgttcgccta cgccctcgac
    13201 cgcggcgcgc aacagggcta tctggacccg cacttcagga gtgtcgcccg gcgtggcggg
    13261 cagggcgtgc tggcccggct ctcggtcggt gcggacggcc gtaccgacct caccgacatc
    13321 tccgtcggca ccaatgtcgg cacgtacgcg tactacgtcg gccgcccccg ggccgtcaac
    13381 gacttccacg ggctcggggc cttcctgatc atgaacgagc agctgcacga cgatggaggg
    13441 atggcatgaa cgcgtccaga agagtcgtgc cgggtccccc cggcgccgcc tcctggcggc
    13501 tgaagtggtc gccgtcggcg cgcaccgacg ggctcggtgc cttcgagacc gtcggggacg
    13561 accgcgccca ctcgcacccc gccggccatc cgcacatctg cgccagcggc gacgactggc
    13621 gcttcaccac ccacaccgcc gaccgggtgc gccccaagtg gggcatccgc agctccctcg
    13681 gcgacaccta tctgctgctc accgacctgc gcggctacca actcgcctag aggagcggtc
    13741 ccgtgacatc ccacatcgcc ggacccggac gggcggcggc gttcatcctg tgcacgctgg
    13801 ccgtcgtcct cggcctcgcc caccccgccg ccctcgcggc cccccacccc acggcctccc
    13861 gccccaccgc cgggtacgac gtacgcgact acggcgccaa gggcgacggc tcagccaacg
    13921 acacccccgc catcgacaag gccgtcaccg ccgcggccac ggccggcggc ggcaccgtcc
    13981 gcttcccgcc cggcacctac aagtccgcca acaccatcca catgaagagc catgtgacgc
    14041 tccagctcga caagggcgcc acgatccggg gctcctccgc gcgcacctac gacccgcccg
    14101 aacccaacgc ctacgacaag taccaggact tcgggcacag ccacttccac gacgcgatga
    14161 tctacggcga caggctgacc gacatcggct tcaccggcga gggggtcatc gacggcggcg
    14221 gcgacctgat caccggcaac ccccggtccg gccaggcgga caagatcctg tcgctgaccc
    14281 gctgcgacgg actccgcctc ggcgacggtc tcaccctgcg ccgcggcggc cacttcgccg
    14341 ccctgatcaa cggctgcacg aacgtcgtct ccgacagcct gacgatcgac accgcgggcg
    14401 accgcgacgg ctggaacgtc atctccacca ccaacgtcac gatcacgggc gcgcacatct
    14461 ccgccaacga cgacgccctg gtcttcaaga gcgactacgc cctcggcgcc acactgccca
    14521 gcggccatgt ccgggtgagc gatgcggtgc tgtcggcgcg ctgctgcaac gccctgatgt
    14581 tcggctccga gacctgcggg gacttctcgg actaccagtt cgagaagatc cgcatcgagg
    14641 gtgccgacaa gtccggcctc ggcatggtct ccatggacgg cgcgaagatc tccgacgtcc
    14701 actaccgcga catcaccatg acgcacgtcc actcaccgat catggagaag atcggcacgc
    14761 gcggacggtg cgggaacagt ccgggtgtcg gatcgatcag cgacgtgacg tacgaccaca
    14821 tcaccgccac cggcaacagc ccctccttca gcccgaccct ctggggcgag aacggccacc
    14881 ggatcagcgg gatcaccttc acgaacgtcg acatcaccgt cccgggcggc aacggcaccc
    14941 tgtccaccgg ggtgccgggc aacgacccga acgactacaa cccgaagagc atcggcaccc
    15001 ggccggcgta cggctggtac ctgcacaacg ccgacgacat ccggttcacc gacagcgcag
    15061 tgcgctacgc cgccgacgac ggccgccccg ccgtcatcgc caacgcggcg agcggcatcc
    15121 ggctgacccg gttcacggca caggagggga gcagatcacc ccacgacatc ggcctgcaga
    15181 acgtcacggg ctactgcctg gccgacagcc acaccaccac cggcggcgca ctgcgcgtct
    15241 cggcgagcgg gtccagcgag gactgcggta ccccggcccg ccccctcgac ctggagaacc
    15301 cccgccaggc cttcctgcgc gcctccgtcg gcggcctctt cctgcactgg gggctgcgca
    15361 ccgctcccgc ccacaccagt tgcacggcct gggagaagga cgtcacgaac ggcggctgga
    15421 caccgcagta ctgggtgaac gaagccggaa agctgcatac gcagtacctc gtactggcga
    15481 ccttccacag ccggctcggc tacgcccgcc cctggccgtc gaagatcccc ggatcctgct
    15541 ccaccaagcg ggacttcctc ggtgaactga tcaacgccgc caaggccaag ggcatgaagg
    15601 tcatcctcta catgaccgac gacccccagt ggcacgacga cggcggccac gaatggctcg
    15661 actcggccgc ctactccgcc tacaagggca agaacgtcga cctgaccacc cgcgacggct
    15721 tcggcgagtt ctcctacgac aacttcttcg aggtcatgaa ccgctacccg gacctcggcg
    15781 gcttctggat cgacaacgac aacgcgtact gggagagcca ccacctctac gagcagatct
    15841 accagaagcg ccccaactac accctcagca acaacaacga agacacgccg atcatggaca
    15901 tgatcagcaa tgagcagaag acgggaatga cgcccgcata cgactacccg caggccgtgt
    15961 acaccgccca gccccgcctg acggaggccg acttcaaact gccgtcgacc ggcgcctggt
    16021 ggtacgacgg ctccgacccc acggtcgacc gcggactcac cctcggccgg ctcatcagca
    16081 acgccggttc ctcggtgaag gccctgatgg ccgagaccgc tgaggtcaac ggccagttcc
    16141 cgccgaacca ggccgccttc aacacctttg ccgactccta cctcgacccg atctgggagt
    16201 ccctccacgg caccgagggc ggcggctaca tgtacggcgg cctcgcgccc ggcgggtgga
    16261 acgacggcgc ccacggtgtc accaccatcg ccaaggacga ccccgaccgc cagtacatcc
    16321 acgtcctcac cccaccgagc acctccaccc tgcgcgtccg cgacaacggc taccgcatcg
    16381 cctccgtcac caacctgcgt accggcaaac ccgtctcgtg gtcgcagtcc ggcggtgtgc
    16441 tcaccctcac cggcctcggc ggctgggacc cgtacgacac cgttctcaag gtgatcaccg
    16501 ccggccgcca gggcatcgcg accggtgtca cggtgaccgc gagcgcctcc gcgagcggcc
    16561 acgccgcctc ggccgccggc gacggcgacc acctcaccta ctgggacaac gacaagaccc
    16621 tgccggtcac cctcaccttc gacctcggcg cggcgaagca ggtccgctac ctcggactca
    16681 accagcgcga ggactccgtc gcctacgccc gctccgccac cgaacagtcg gcgcggatca
    16741 aggcgtacca ggtgttcctc agcaccgacg ggacccactg gaccaaggcc gccacgaccg
    16801 gccaactccc cagcacccgc ggtgtgcaga ccatcgacct gaccgccgcc accgcccgct
    16861 acgtccgcct cgaggccgac tccacctggg ccgccgccac cgacaccacc cgctaccggc
    16921 ggctgcggat cgacgaggcc tggatcggca cctcctacgc cacgcccgcc gtaccgggag
    16981 gacgacgccc atgacccggc tcaggacagc cacggccgcc gcggccggcc tgctcgtcgc
    17041 caccgcgata ccgctcatgg ccaccccgca ccgggcggcc gcctccgaca acggccgggc
    17101 ggtccggccc gccatgggct ggagcagctg gagctatgtg cgccggcagc ccaccgaggc
    17161 cgcgatcgag gcacaggccg atgccctggt ctcctcgggc ctggcccggc acggcttcgt
    17221 ccaggtcaac ctcgacgact tctggcagaa gtgcgacgca aacggcttcc aggtcgacgg
    17281 ctacggccgc tggagccccg accccgccaa gttccccgac ggcatcaagt ccctcgccga
    17341 ccacgtccac gccaagggcc tgaagttcgg cttctacgtc actcccggca tcgcgaggaa
    17401 cgccgtcctg aagaacaccc cggtcgaggg caccacgtac cacgccaagg acatcgcgga
    17461 cacctcgaag accgagaaga actacaactg caagaacatg tacgccctcg actacgccag
    17521 gcccggcgcg caggagttcg tcgactcctg ggcccggcag ttcgcctcgt ggggcgtgga
    17581 ctacctgaag atcgacggcg tgggcggcca ggacatcccc gacgtccagg cctgggacaa
    17641 ggccctgcgc gccactggcc ggcccatcac cttcgccctg tccaacaacc tcccgatcga
    17701 ccaggccacc acctggcgca cgctcgccaa cagctggcgc acccagggcg acgtcgagtg
    17761 ctactgcggt ccgggaccga gcggaagcgg atacccgctc accgactggg cccatgtcgc
    17821 ccggcgcttc gactccgcag ccgcctggca gccgtacgcc ggccccggcg gctggaacga
    17881 cctggactcg ctggagatcg gcaacggcga ccgggccggc ctcgacgccg accagcgccg
    17941 ctcccagttc acgctgtggt cgatggcggc cgcacccctc ctgctcggca ccgacctcac
    18001 ccgcctcgac ccggtcgacc gggcgatgct caccaacgac cggctgatcg gcgtggacca
    18061 ggacggcatc gccgcgcaac gggtcgtgaa cagcggggcc ggacaggtct ggagcaagcg
    18121 cgagagcaac ggcgaccgtg tggtggccct gttcaacacc ggaacctccg gctccgccac
    18181 ggtcaccgtg gactggtccc ggatcggtct caccggctcc ggcgacgtca ccgacctgtg
    18241 gtccggtgcc cacaagggca cggtcgccgg ctcctacagc gcggccctcc gcccggggga
    18301 gacccgcctg atccgggtgc gacccgtcga ctcacgtggg acggcggtgg accgctgacc
    18361 ggcggcagcg atcggccgac ggcctggcgc acacggtctg ccgacagcga cggcggcgtc
    18421 ccgcagcagc cctacgacta cctcgaggtc ttggcccggt acccgggccg aggggagcaa
    18481 cagccatgaa aaccagcaga gttctgccct acgggctggc cgccgtgctc gcccttccgc
    18541 tggccggact gagccagggc accgcacacg cggccaccga ctaccaggcc gaggacgcga
    18601 ccatctccca ggggaccgtc gccggcaacc acaccggcta cacgggaacc ggtttcgtcg
    18661 actacaccaa cgtcaaaggc tcctacgtgg agttcagggt ctccgcagcc gccacgggcc
    18721 ccgcctcggt caccctgcgg tacgccaacg gcaccgcggc cgaccggccg atggacctct
    18781 ccgtgaacgg caccgtcgtg gcgccggccg tctccttccc ggccaccgcc gactggaaca
    18841 cctgggcggc caaggccgtg aacgtgacgc tgaaggcggg caccaacacg atccgggcga
    18901 cggccaccac ggcgaacggc ggccccaacc tggaccgcat cagcctcgcc gccgtcaccg
    18961 acacccaggc gcccacccgc cccggtcagc cctcctgccc ggacatcggt gaggaccgcc
    19021 tgaccctggc ctggggcgcc tcgacggacg acacgggcgt cgcggcctac gacctctacg
    19081 agcacggcaa caagatcggc gaggcgccgg gcgacaccac cacgaagacg ctgaccgggc
    19141 tcgccccgaa caccacctac gacctcaccg tcatcgcccg cgacgcggcc ggcaacacct
    19201 cgcccgccag cccggtcgtc gactgcacga cgaagcccag ctccgacacc acaccgccga
    19261 ccgcaccggg tgccttgcac acggccgaca tcacctcgaa cacggtcggc ctcacctggg
    19321 gcgccgccac cgacgaccgc ggtgtcaccg cgtacgacat ccgcagcggc accaccgtct
    19381 accggaccgt caccggtggc acctcggcca cgctcaccgg gctcgcctgc aacagcccct
    19441 actccctgga cgtggtggcc cgcgacgcgg ccgggaacgt gtccccgccg agcaacaccg
    19501 tcaccttcac caccaaggcc tgcgccaccg acggcggcgt cccgtcgtcc atcgccacgc
    19561 tctccaccgg ctggaccatc ccctggggca cctactggat gcccgacggc aagaccgccc
    19621 tcgtcaccga gcgggacgac ttccgggtct ggaaggtcac caaggacggg acgaggaccc
    19681 aggtcggcac cgtcccgaac gccgtcacca ccaacggcga gggcggcctg ctcggcgtcg
    19741 ccgtcgaccc cgagtgggcc acgaaccact acgtctactt catgcacacc gccgccgagg
    19801 gcaaccgggt cgtccgcatg acctacgacg gcagcaccct caccggctac aagatcctgc
    19861 tccagggcat caggaagaac cgctatcaca atggcgggcg cctcgccttc ggccccgacg
    19921 gctacctcta cgtctccacc ggcgaggccc agcagcccga tctcgcgcag gacaagaact
    19981 ccctcaacgg caagatcctg cgcatgacca ccgacggcaa gccggcgccc ggcaacccgt
    20041 tcggcaacta cgtctactcc ctgggccacc gcaacccgca gggcctcgcc ttcgaccgca
    20101 acggccgcct gtgggaggcc gagttcggca acagctccaa ggacgaactc aacctcatca
    20161 agcccggcgc caactacggc tggccgacct gcgagggcac ctgcagcgtc gccggtatga
    20221 ccaaccccaa ggccacctgg aacgtctccg aggcctcgcc cagcggcatc gccatcgtcc
    20281 gcaacgtcat ctacatggca tccctgcgcg gcgaacgcct gtggcgcatc cccgtcaacg
    20341 gcgacaccga gagcgtcggc accccgaccg cgtactacgt cggctcctac ggccggctgc
    20401 gcaccgtcac caaggtgccc ggagccgacg aactgtggct gtccaccacc aactgcgaca
    20461 acaacggcgg cgccgccgac ggatccgacc agatcttccg cgtcacgatc aagtgaggag
    20521 gacgaggtga cgcaggcgaa ccgacgccgc gtcaggtccc gtagagtgcg tcgacctcgt
    20581 tgccgtacgc cttctcgatc gccttccgct tgagcttcaa cgacggcgtg agcaggccgt
    20641 gttcctcggt gaacggctgc gccaggatcc ggaaggtacg gatcgactcg gcctgggaga
    20701 cgagggtgtt ggcggcgacc accgcccgcc gcacctccgt ctccaggtcg gcgtcacgca
    20761 ccagctggac cggggtcatc ctgggcttgc cgcgcatctg cagccagtgc tccacggcct
    20821 cctggtcgag ggtgaccagg gcggcgatgt agggccggtc gttgccgacg acgatgcact
    20881 ggttcaccag cggatgctcg cggacccgct cctccagcac cccgggggag acactcttgc
    20941 cgccggaggt caccaggatc tccttcttgc ggccggtgat ggtcagatag ccgtcctcgt
    21001 ccagcgaacc gaggtccccg gtggccagcc agccctcgtg cagggtctcg tcggtggcct
    21061 tgggattgtt gaggtagccc tggaagacgt tgccgccgtg cagccagatc tccccgtcgt
    21121 cggctatgtg cacggtcacg cccggaatgg cctggccgac cgtgccgtag cgggtgcgct
    21181 cgggcgggtt ggcggtggcc gcggccgtcg actcggtcag gccgtacccc tcatagatct
    21241 gcacgcccgc gcccgcgaag aacagcccga gccggcggtc catccccgaa cctccggaca
    21301 tcgcgttgcg gatacggccg cccatcgccg cgcggacctt ggcgtagacg accttgtcga
    21361 agaactggtg ctgcatgcgc agccccgccg acgggccggg cccgatgccc cacgccttcg
    21421 cctcgacggc ctccgcgtac ttcaccgcga cgtcgaccgc cttctcgaac gggccggatc
    21481 tgccgtcctt ctccgccttg cgacgggcgg cgttgaagac cttctcgaag atgtacggca
    21541 ccgccaggat gaacgtcggc cggaacgcgg ccagatccgg cagcagggcg gcggcgtgca
    21601 gctgcggctg gtgcccgaaa cggacccggc cgcggatcgc ggcgacctcc accatccgcc
    21661 cgaagacatg cgcgagtggc aggaacagca gcgtggacgc ctcgtcgtcc ttcttggtgt
    21721 ggaacaccgg ttgccaccgc tggatcatcg tgtccgcctc gtacatgaag ttcgcgtgcg
    21781 agaggacaca ccccttgggc ctgccggtgg tgcccgaggt gtagatgatc gtggcgaccg
    21841 agtccggggt gacggcctgc cggtgcctgt gcaccacctc gtcgtccacg tgcgcgccgg
    21901 cgtcgtacag ctcctgcaca cagcccgcgt ccagctgcca cagctggcgc agctgcggga
    21961 ggcggccgat gacggtggcg atggtcatcg cgtggtcctc gtgctccacg atcgccgcgg
    22021 acacctcggc gtcgtagagc atccagaagc actgttccgc ggaggaggtg gggtaga
//
