LOCUS       NZ_WHOM01000078        26333 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces apocyni strain TRM 66233 522, whole genome shotgun
            sequence.
ACCESSION   NZ_WHOM01000078
VERSION     NZ_WHOM01000078.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces apocyni
  ORGANISM  Streptomyces apocyni
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 662149)
  AUTHORS   Liu,W.
  TITLE     Streptomyces poacynumensis sp. nov., a endogenous actinomycete
            isolated from Poacynum hendersonii
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 662149)
  AUTHORS   Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2019) Key Laboratory of Protection and Utilization
            of Biological Resources in Tarim Basin of Xinjiang Production &
            Construction Corps, Tarim University, Xingfu Road, Alar, Xinjiang
            843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABySS v. 2.2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009739465.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 17:09:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,397
            CDSs (total)                      :: 6,319
            Genes (coding)                    :: 6,205
            CDSs (with protein)               :: 6,205
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 34 of 114
            Pseudo Genes (incomplete)         :: 100 of 114
            Pseudo Genes (internal stop)      :: 6 of 114
            Pseudo Genes (multiple problems)  :: 23 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:56:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 142143
            Orig. end                         :: 168476
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHOM01000078.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26333
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..26333
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26333
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16333](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16333)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(391..2073)
                     /locus_tag="GCN81_RS29240"
     CDS             complement(391..2073)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013232.5"
                     /locus_tag="GCN81_RS29240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156727562.1"
                     /transl_table=11
                     /translation="MNRTADVIIFTALPEETAAAREHLDEPITERVVSGSIFKLGTFVG
                     RHTRWTVALHETGPGAEGAAALVALAVAALSPRYVFFTGIAGGLKDVTHGDVVAGRHVY
                     DYQTGVDGPEGVRPRMQTFPPAHDLIQRAQVVAGEKEWQARIQGPAPTCLPEAYVKPIA
                     AGSKLVTDPESPTAQYLRDFAGDALAVEMEGYGFLRGAHISSGVGALVVRGISDLLVDK
                     GRENDKVRQPAAARHAAAFTYELLNQLGDSRTHRPGLGEELLSSRRTGPLGGATAGFGP
                     DDTFVAIGPDGSIERWALDAGAALPGAPGSAGLRQGHQALVSSVRHSVAVARPGALELV
                     HFKGRTGEHHRVPVPLGDDEFLVTSGGNVLATHDRRRLAVRSFDDGRVLDELFCPPNLA
                     ASAIDATGRTGALATSNRVHVHRSGAPNLALSIRNVLEFMKPGCSVAVSPSGGYVACAT
                     MRELCVWRTDDESVVLHRRLSGKEMLDSGGATGMRLSCTDTGAVLWLRRGKLSHVTDAP
                     EILQLEQTGRYDDAVVHPSGHLLGAVGDKGMVRVWEWHDRGGQ"
     gene            complement(2099..2686)
                     /locus_tag="GCN81_RS29245"
     CDS             complement(2099..2686)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174717.1"
                     /locus_tag="GCN81_RS29245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156727563.1"
                     /transl_table=11
                     /translation="MSHIENVTASHLLLVEYDHLKAEQRARIGFRDNLLYVTLASMAAI
                     VAAVLQGPSRPGLLLLMPPVCVILGWTYVVNDEKISAIGRYVREHTAPHLEAAAAAATA
                     PAPPAAAPPFTEAFGWERVHRSDAHRRNRKRLQLGADLLAFCGAPLAALAVYWAGEPSH
                     PALLGTSFAETLTILLLAVQIARYADLRTGAS"
     gene            complement(2880..3608)
                     /locus_tag="GCN81_RS29250"
     CDS             complement(2880..3608)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GCN81_RS29250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_156727564.1"
                     /transl_table=11
                     /translation="MDLSKKERDRPKRSRWHFGPRWVELTVVFVATVVTGFVGGRASDV
                     GSSSDRAEPAPTVTVTVTQTVTASPTPLSGSSSSPTRDGGSESPTGEPIDGGTGESPQP
                     AEVYLADLDRVSDRGYVNTSPVTMRGTNYPKSIRIGCDTSSSDEAVYNVSGYKRLTATV
                     GLPADTGNSIASVGSIKVFNASGNRMGEPVTVRSSAVGQLAVDITDQDQIKITCTLIRS
                     GDPDRTSAVSGLGDATISMS"
     misc_feature    3818..3835
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            4215..4871
                     /locus_tag="GCN81_RS29255"
     CDS             4215..4871
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061447.1"
                     /locus_tag="GCN81_RS29255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_156727565.1"
                     /transl_table=11
                     /translation="MIRVVVVDGEQLVRSGLKLILSSAGDIEVVADCGGAEAVEAVRAH
                     RPDVLLLDIRMPDVDGLTVLRQVTALESAPGVAMLTTFDAREYIDEALRAGAAGLLMKN
                     TAPEQLVHAVRVLAVGGRILAPEATSAVIDGYLTASREIEAARSVEALTVRERQVLALV
                     GAGLSNWEIARRLRLSHGTVKDHVSSLLAKLGGVNRVQAAVVADRAGMVGRRTGG"
     misc_feature    4512..4514
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5325..5891
                     /locus_tag="GCN81_RS29260"
     CDS             5325..5891
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="GCN81_RS29260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_231627059.1"
                     /transl_table=11
                     /translation="MEVEGGPALTPCDVLVVDIDRLEEVHDPVPVAAVTYGAEMRHPGL
                     LEADVRAIVDRDDLDDAFLEAVHEVAAGNGWISPTLVRPLLRGPHTAHSAHSAEAAQQP
                     AHTAARVRRRDPALTAREYEVVSLVTQGMNNSEIAGALYIAESTVKFHMSNILQKTGFR
                     DRSQLAARVPTRVPARVPARLSVAR"
     gene            5957..6142
                     /locus_tag="GCN81_RS29265"
     CDS             5957..6142
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126210.1"
                     /locus_tag="GCN81_RS29265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156727566.1"
                     /transl_table=11
                     /translation="MGNKKETLRWAPVAILLVLAIIAPLFGDSPTAVVTPLLLAIILAS
                     ANGVQLKRERAAHDAG"
     gene            complement(6211..7062)
                     /locus_tag="GCN81_RS29270"
     CDS             complement(6211..7062)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.5"
                     /locus_tag="GCN81_RS29270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_156727567.1"
                     /transl_table=11
                     /translation="MKTSMGSQPSLGSQVSLDSQLSLGSQVSTELRKLTTTRLWWILLL
                     TMVVCSAGLTALVVFGGLNAPRSPLRFDSADEVVPAYNLPVALAYVFPLGIGTALVTQE
                     YNSRTITATLLSEPRRMRVYGAKVLVGLGTAFVYGAASVGASALVAAALLSGHGESPYL
                     MDGPVLGALSGSVLVMTLWGAIGVAVGALVRNQVVAIVGILLVTQFLEPTLRILASQLG
                     SPGLGNLLPGGAGEIAGGGTIMTAAADAEGAPQALGFLVLALYAVVTGALGGLRFARYE
                     VA"
     gene            complement(7059..7799)
                     /locus_tag="GCN81_RS29275"
     CDS             complement(7059..7799)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020548990.1"
                     /locus_tag="GCN81_RS29275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_231627061.1"
                     /transl_table=11
                     /translation="MKQVEEEKYVISVRGLTKEFQGTRAVDSVSFDVARGRITGFLGPN
                     GAGKTTTLRMLLGLIRPTEGTARFWGRPYGELPTPTRRVGVGLDGGAFLGGRTGRGHLR
                     CYARAAGCGPERIARLLADVGLEGAADRPVSGYSTGMKQRLSLATALLGDPELLILDEP
                     SNGLDPEGMLWLRRFLRSYAAGGGTVLLSSHLLGEMEQIVDDVLLMHHGRLLCAQPLSG
                     LLETDERLESAFMRLTQAGIGGRA"
     gene            complement(7842..10004)
                     /locus_tag="GCN81_RS29280"
     CDS             complement(7842..10004)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="GCN81_RS29280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_156727568.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.5e-35, bitscore:
                     114.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVRTRRARRVREVQQFAQSECGLCCIAMVLSAYGSRDSVAALRR
                     EHEVGRDGLTIKEIATILRGRGFQVRAFRAGANRLDGLALPLIAYWDDSHVVVVEEITD
                     RHVTVVDPAAGRRKYPVEEFERHYSGLALEATPTADHQPVRHREPSVWREFLRSLSGAR
                     RPLLQAFVMSLVLYSFTIFMPIATQHAVNDYAGYLENSPIALVLLAFTVPMAVYFVLSL
                     LRTVCLAAVIRGLGEAMMGRTFRKLLDLPYKYFANRSQGELFYRLSSITSVRDMISSQL
                     PAVLLDVGSLIVIFGYMFHRSFILGATAFAIFLTMLTVAVCMYRPLRRVTEREISETAK
                     SSSLQMEALSSIETLKVSGMTDTFFRDWRKVYSVGMEQTQRRIVLQGVASSGYSVFQVF
                     GPLLVLAVGLWLVLDGSLDLGSAVAAQTLTATSLGMVMSLSGVFTQLITANTQVARVGD
                     ILHQPESRGAFGDRPVAIRGAVSLREVGFTYPGAKTPALRDISFDIRPGERVAIVGSSG
                     SGKSTLGKLLMGLYPIQSGDIAYDGVSLQEIDADTFYANTAYVPQDIVLSNRSIAENIR
                     FGVPEATIEAVVEAAREAHVHEDVAAMPLGYHTPVREMGGSLSGGQRQRIALARALARR
                     PRVLVLDEATSALDTVTESRIADALDRLECTRIVIAHRLSTIVSADLVVVLEHGRVVQT
                     GRHAELLAESGLYRELIRSQVDLSAV"
     gene            complement(10001..12859)
                     /gene="lanM"
                     /locus_tag="GCN81_RS29285"
     CDS             complement(10001..12859)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="GCN81_RS29285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_197287829.1"
                     /sec_met_domain="DUF4135 (E-value: 7.3e-72, bitscore:
                     237.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.7e-21, bitscore:
                     69.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPQELVKRVTEERADVFGAFYTPYLTDCARQIAGYLDEAAAEAA
                     DAAGDVADAADADVDAESVVESVLRSLMGVCVETGVRTLIASFRAEGGTYEAFHARVAG
                     AEGRGALLARFPELDRLLRLVTARTARTAREVLRALAADRRQLAELLGAEGPVTSLTTG
                     LGDAHRGGRTVCLVGFGDGTRVVYKPQQDNCQSLLATLRTLLDEDGSFFGPLHPRSLVR
                     SAYVWQEFIEHTDLDDVTEGAQYFRRFGRVAALLSMIGATDLHHENIIAVPQGPVVIDT
                     ETLVSLPNGPTDTSASASASASAQSPSAGAALNLDIEHSVLNTLLFPARYAGAKLDIDI
                     SGIGCVRPGASEHLTSYTVVDAGTDDIRFDRSPVVVEHGSNMAKVAGEPLDPRDWVDEI
                     SAGYGEARELLATLRDAIEAAVRASGDWAVRQVVRPTYVYARFLEASTHPVHLGSTEAR
                     AELLGKLPRYYRGAAKESADALHREEVAALLDLDVPFFTVDCDSGLLRGDLDEEMRSAA
                     DSTPREAALAAVRSFFARPPQRDLSYLRYALAGSVDDVWDVRRASRREVFPDLADATAW
                     HSTLRDLVVGEESAPTWLLPQLRGDGLRLGGVNAPLYDGGGLLLYLAQAEALTGTSPLG
                     VDIAQVSRAAMQPQPQPPFAGDTTPLAMSPFTGALSELVTDWEIRRRRTPDALFTHTEL
                     HPADRPLDVDSLTAADFDYLNGYGGYLVYLAAYQKHGAPELTGVPPERLLRRLVTVDGT
                     PEEHTGELGLAHGRFGRITAMSAMVAEGLDGGSGARDHLERFAHAYVRNRWQDESLRDR
                     ASGSGWCKGYAGVAYAAGELLTALGESTGRVRTAIAPEVERLADGDLGHDISFCHGLAG
                     RIAVLCQLADRFDWPELRDEAAALHTAFLDRYAAADGGWSCGIGTEPHLPSFFLGLSGW
                     HYARLMLHHPQAALPRCLGGRS"
     gene            complement(12964..13155)
                     /locus_tag="GCN81_RS29290"
     CDS             complement(12964..13155)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="GCN81_RS29290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_156727570.1"
                     /transl_table=11
                     /translation="MGNIAMNDATGYVSADELVELADAPESLAAGITPTILPATGVIVG
                     ASAALQGGCPTSGCTKRC"
     CDS_motif       complement(13084..13155)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGNIAMNDATGYVSADELVELADA"
                     /locus_tag="GCN81_RS29290_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12964..13083)
                     /prepeptide="core"
                     /locus_tag="GCN81_RS29290_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="3526.1"
                     /monoisotopic_mass="3523.9"
                     /core_sequence="PESLAAGITPTILPATGVIVGASAALQGGCPTSGCTKRC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGNIAMNDATGYVSADELVELADA"
                     /leader_location="[13083:13155](-)"
                     /alternative_weights="3544.1"
                     /alternative_weights="3562.1"
                     /alternative_weights="3580.1"
                     /alternative_weights="3598.2"
                     /alternative_weights="3616.2"
     gene            complement(13223..16333)
                     /gene="lanM"
                     /locus_tag="GCN81_RS29295"
     CDS             complement(13223..16333)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="GCN81_RS29295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_197287830.1"
                     /sec_met_domain="DUF4135 (E-value: 2.7e-65, bitscore:
                     216.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2e-37, bitscore:
                     124.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSHVDSADSPDIAEALRTYLPELTSPELIKHAEERLRTAHAADG
                     AQDEKRRRPARPSGYDPSLDSDGLFHDYFAHFVEPWAEQVRAAVASSPVVSTDNNTVID
                     DFLAHQTGLVSRLMVRTLVEELHRHRSQGLLDGETPEERYAAFRRWTNSDEGHGELLAR
                     YPHLFHLVDCQVEASARYVREVLREIEVAGAGLSAVIRGGDGRSAPLEVERLSLGEGDT
                     HNGGKSVAQIVFTDGSRVLYKPHPMDAEAGYSSFVSWMNDRLGNDLPTVSVLPTEHGGF
                     VEFIPTQEYAGEQKDYFARIGAIGGILFLLKATDIHFENMVSCADGPVVIDTETLLSPR
                     LTVPAAYDDGAASRLGALTLQDSVIGSGLLPLVVRAGDKDPGMDIGAIGYDTGQRAPYK
                     ALSLQNPGRDDMFVGMVTTETTAANANLVVQRATELPVTAQRDIIKAEFRRVLEYAAAQ
                     PDAVMEAIETFLGDARFRHVNQATIFYGQLLRMATHPHAMADPVVRAAVLNRVVLRTGD
                     NPALADEEVRQMAEGDVPYFSYSARGRALYAGGRVVRADALAEPPLETVRARVHGLDEA
                     VIARELRLIDYSFVNKLPTDQERTGFVPVRAAVSPAAVSPAADRPAADRPAAVSRARLV
                     AEAERIGDRLLATLIASTDPRHPATWIAPQVTTDSQSQWSPGTLGYDLYGGSPGPALVL
                     AGLARETGRRDFADAARRVLDPVEEQLRGGQLAEQGVSVGGMTGLAGTAYALAVARDLL
                     DEPDGTRAGELARELARSSGPEVGTDYVSGLAGALAVTLALHERATTPAEKRAVAEAAA
                     TVAAAEVRALGGIDLGLRDTADARVTSYTGYAHGAMGIGPVLIRYGTEFADAPVRDLGL
                     RITGAVLDSYDASDRDWPRVWDEPERSYGWCHGAPGLLLGSLTAVEYATGSVPDAVLVR
                     LAELTVSRGFGNNPTYCHGDLASAEVVALAAQRLPGVFDDTGVFGDTGGIDDLYPRLFG
                     EVVERYEQRCDTKYAYSNSLMVGEAGLAWSVLHHLDPEGYPSLLRFA"
     gene            complement(16398..16583)
                     /locus_tag="GCN81_RS29300"
     CDS             complement(16398..16583)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="GCN81_RS29300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_197287831.1"
                     /sec_met_domain="mature_ha (E-value: 2.6e-09, bitscore:
                     31.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANANVGILEEISDQNLDAVSAAGQGWGTTLSSLSCYGASYVLGN
                     NGNFCTATAECQSNCQ"
     CDS_motif       complement(16515..16583)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MANANVGILEEISDQNLDAVSAA"
                     /locus_tag="GCN81_RS29300_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16398..16514)
                     /prepeptide="core"
                     /locus_tag="GCN81_RS29300_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.30"
                     /molecular_weight="3732.0"
                     /monoisotopic_mass="3729.6"
                     /core_sequence="GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNCQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MANANVGILEEISDQNLDAVSAA"
                     /leader_location="[16514:16583](-)"
                     /alternative_weights="3750.0"
                     /alternative_weights="3768.0"
                     /alternative_weights="3786.1"
                     /alternative_weights="3804.1"
                     /alternative_weights="3822.1"
     misc_feature    16590..16605
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     misc_feature    complement(16640..16660)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.14"
                     /tool="antismash"
     gene            complement(17034..18806)
                     /locus_tag="GCN81_RS29305"
     CDS             complement(17034..18806)
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012471.5"
                     /locus_tag="GCN81_RS29305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_197287832.1"
                     /transl_table=11
                     /translation="MRTKMTFWLVAAATTAALAVGTGYGAAAPPPDRPASAQDERAYVY
                     RVHDGAHAADSRLAGFDLIEDRDGDDLFVLGDAGTAKDLKAAGLEATVEQRLSPAPWGP
                     PKRSGQAPRLTAKVAEETYYGGYRTVNAQYAHLDQVASDHSGLATVFDVGDSWRKATGR
                     PNGYDLKAICITKKQSGDCQLNPDSSKPRLLVQAQVHARELSTGEMAYRWIDYLTDGYG
                     TDPTATEILDNREIWVVPIGNPDGVDMVQQGFTGGPSQQQWHRKNSNHTHSSGCSEGSY
                     GGEGIDLNRNNGSHWGGAGTSSNPCSKVYKGPSADSETETRALQALYRDLFPDTRPAGD
                     NAAADPDTQGMFVSMHSYSNMVLFPWGFNSSIDAGNDAALRTMAKDMANLAGGWQYGQP
                     GEILYNASGTHDDWAYDDLGVPSFTWEVGPSGGSCGGFHPSYSCQDTFWNQVKPMLVYA
                     AEHAENPYGGGTTPPPSECSATNGTNVAIPDNGSAVTSGIEISGCTGNASDASTVEVHV
                     EHTWRGDLTVDLIAPDGTVYPLKSASGGDSADDIHETYTVDLSGEARNGTWSLRVQDTA
                     RYDTGTLDTWTLSL"
     misc_feature    18785..18799
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.6"
                     /tool="antismash"
     misc_feature    complement(18879..18893)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            complement(19122..19742)
                     /locus_tag="GCN81_RS29310"
     CDS             complement(19122..19742)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008734468.1"
                     /locus_tag="GCN81_RS29310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_197287833.1"
                     /transl_table=11
                     /translation="MAHDSNGLRSVSAMPLELLRTPPPKERADAARNRAAVLEAAARLF
                     AEKGVEAVSMDQVAAAAGVGKGTLFRRFGDKSGLAVALLDARERVLQEAILYGPPPLGP
                     GAPADERLAAFLNAYFDYLLEHLALVRMSETATPGARYRIGAYRFWHRHVAILLATAPD
                     PDPDHAAHALLAALAADHVAALLPELGEQRMRTGLLHLAQSAM"
     gene            19780..20106
                     /locus_tag="GCN81_RS29315"
     CDS             19780..20106
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008734471.1"
                     /locus_tag="GCN81_RS29315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_156727573.1"
                     /transl_table=11
                     /translation="MTALITRDELAAAIKAESVTVVDALGGAYYAQQHLPGALALIPAD
                     VDAQAPALLPDRDAAIVTYCSNPACPNSGQVADRLTALGYTNVRKYREGIQDWVEAGLP
                     TESA"
     gene            20231..20569
                     /locus_tag="GCN81_RS29320"
     CDS             20231..20569
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GCN81_RS29320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_231627063.1"
                     /transl_table=11
                     /translation="MAVRDGQSPVGQVRLAGSRIVADGPADELSRQASAEATVRWTRDG
                     RPFEQATAEPTRFVRRLFEEHGEAIDGLEVRRASLEDTYLTMVRELEEAPGSVRYGQTA
                     HPFEEGAR"
     gene            20858..21418
                     /locus_tag="GCN81_RS29325"
     CDS             20858..21418
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024110.5"
                     /locus_tag="GCN81_RS29325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_231627064.1"
                     /transl_table=11
                     /translation="MPHGMVGHLIGKIIMVSGTALASMALALAAGVFLVDGVARQGGGA
                     WLTLVWVVPLGLLATLPVGAIIGSLVDSPRTIGLLMLPVMGLVVISGIYFPLSKLPEWV
                     QVVGQVFPVYWLGLGLRSALLPPDAVAAEIGESWRQLETAGVLGAWAVAGLLLAPSVLR
                     RMARRESGSAMAEHRSKAMQRVG"
     gene            complement(21634..22653)
                     /locus_tag="GCN81_RS29330"
     CDS             complement(21634..22653)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1273: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157436.1"
                     /locus_tag="GCN81_RS29330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hemolysin family protein"
                     /protein_id="WP_156727574.1"
                     /transl_table=11
                     /translation="MSFPMALFVTVVLLIASGFFVAAEFALVAAKRHRMEKAASEGQRG
                     AKAALAGMRELSLMLAGAQLGITVCTLGLGSISKPAISHELDPLLHKVGLPSGLSYGVA
                     FAFAMAVVVFLHMVVGEMAPKSWAIAHPERSAMLLSPPFRAVVKVVRPLIWLLNKVSNA
                     LVRMCRVTPRDELTSVHNREQLTHLVEESERLGLISEADSDLITNSLTEPHTPVGDLQT
                     PVGRITSVSAQADVDAILATAAEHDRSRLLVLDGPLVVGSVHARDALIARARGRAVTAR
                     DLARPVPELTGQDTVGQAIERLRECRASLAVVRDDTGRFTGMVALDDLLARLMHPQAA"
     gene            complement(22650..24050)
                     /locus_tag="GCN81_RS29335"
     CDS             complement(22650..24050)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1273: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005710.1"
                     /locus_tag="GCN81_RS29335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hemolysin family protein"
                     /protein_id="WP_156727575.1"
                     /transl_table=11
                     /translation="MSAVLGLLAVFVLTAGTGYFVAQEFAYVSADRLALAREAEAGDKR
                     AARALKVLERLSFMLSGAQLGITVTGLVVGFIAEPSVSALLRPVLNGMGVPDGAVSGIS
                     VVLAFVLATVVQMVLGELAPKNLALAVPDRLAKSLASSTLAYLKIVGPVVRIFDSTANR
                     LLRRIGIEPVEELHHGATLEELGHLIGESHEQGELPKDTAALLDHALEFSERTLDEVMV
                     PRADAVFVRKGASAADAVRLIAEHGHSNYPVLGDHPDDVGGVLGVRELTRLPAESLTST
                     TAGTLARRPLLLPDTLELPDAVAQMRERGDEFAVVLDEHGGVAGIVTYEDIAEELVGDI
                     ADESDTVVELAVADGDGWLVDAGRRLDEVAEATGIELPEEEDYDTVAGLIVDQLGRFPA
                     VGDRVTVELPDGGKAVIDVRGLDRHVPKKIRLERQAAQSDASESAASESAGSESAPNGS
                     ASSKEELA"
     misc_feature    24242..24255
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.07"
                     /tool="antismash"
     gene            complement(24316..25509)
                     /locus_tag="GCN81_RS29340"
     CDS             complement(24316..25509)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574561.1"
                     /locus_tag="GCN81_RS29340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyltransferase family protein"
                     /protein_id="WP_156727973.1"
                     /transl_table=11
                     /translation="MLRLTRRHAPPLPRQWPAPDTDSGGGAAQDWAAQGESAAGADRAT
                     GADRPVKQRDAFFDNAKYLAIVLVALGHAWEPLRDDSRAAAALYITVYTFHMPAFIVIS
                     GYFSRSFDASPDRLKRLVTGIAVPYVIFEVAYTFFKRWADDDPTYPISLLDPWYLTWFL
                     AALFIWRLTTPLWKMVRWPLSLAVAIAVLASVSPDIGDDLDLQRVLQFLPFFVLGLRLK
                     PEHFQLVRRKEVRVLAVPVFAAALVFAYWATERMNTAWFYRRDSAQELAAPGWAGGVMT
                     LGMFGCSLVLVACFFAWVPGRKLWFTALGAGTLYGYLLHGFLAKGSRFWDWYDAAWVHQ
                     PLGEIVVTLIAATVITLLCTPPVRRAFRFAMEPKMEWAFTPDAATPARDRERATSRR"
     CDS             complement(25568..25678)
                     /gene="allorf_167711_167821"
                     /locus_tag="allorf_167711_167821"
                     /protein_id="allorf_167711_167821"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTWKLCRSFVMTGRGVLRGCRCVARVLGMFCCDATP"
     CDS_motif       complement(25592..25678)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTWKLCRSFVMTGRGVLRGCRCVARVLGM"
                     /locus_tag="allorf_167711_167821_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(25568..25591)
                     /prepeptide="core"
                     /locus_tag="allorf_167711_167821_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="737.8"
                     /monoisotopic_mass="737.3"
                     /core_sequence="FCCDATP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTWKLCRSFVMTGRGVLRGCRCVARVLGM"
                     /leader_location="[25591:25678](-)"
     gene            25847..26068
                     /locus_tag="GCN81_RS29345"
     CDS             25847..26068
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008411999.1"
                     /locus_tag="GCN81_RS29345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156727576.1"
                     /transl_table=11
                     /translation="MASIDLDKVLDKAWADKSLPEILAAPASALKGVSDRDGELLQEAF
                     GVKTVADLAELKYVRWAQALAALDTSAK"
ORIGIN
        1 agctctcgca cgtccacgca gggcggctga cgagcagatg ccgaacccgt gagctgacaa
       61 tccactgctg acatcaacgt cggcgcacaa cggcctccag cccgatctaa aacggtgctc
      121 agcgtccgcg ccccatccgt gcccgaccgg tcggtaagcc acagtcaaca gcgggtgcca
      181 ggtggagccc gaggcttcac cctggcaccc gttgccgcca gtgggggccc ggccaggtag
      241 atcgtggctg tcttctcatg gcccatggcg ataccgctgc actgcttaag cgttcacgac
      301 gcaacggagg tccgggcgga gcccgcctcc ggctcgctgc ggcggtgttc gagatgggat
      361 cggcggccat ggacgctggg agagccgtcc tcactgaccg ccccggtcat gccactccca
      421 cacccggacc atccccttgt cgcccacggc gcccagcagg tgcccggagg ggtggacgac
      481 ggcgtcgtcg tagcggccag tctgttccag ttgcaggatc tccggagcgt cggtcacgtg
      541 ggaaagcttg ccccggcgca gccacaacac cgccccggtg tcggtgcacg acagccgcat
      601 gccggtggca cccccgctgt ccagcatctc cttgccgctc aggcggcggt ggaggacgac
      661 cgactcgtcg tccgtgcgcc acacgcacag ttcccgcatc gtcgcgcaag ccacgtagcc
      721 gccggaggga gagaccgcga ccgagcagcc gggcttcatg aactccagga cgttccggat
      781 gctcagtgcc aggtttgggg cgccggagcg gtgtacgtgg accctgttcg acgtggccag
      841 ggcccccgtc ctgccggtgg cgtcgatggc cgaggcggcg aggttcggcg ggcagaacag
      901 ttcgtcgagc acccggccgt cgtcgaagct ccgtaccgcc agccgacgcc tgtcgtgcgt
      961 cgccagcacg ttgccgccac tggtgaccag gaactcgtcg tcgccgagcg ggaccggaac
     1021 gcggtggtgc tcccccgtac ggcccttgaa gtggaccagt tcgagggcgc cggggcgggc
     1081 aacggcaacg ctgtgccgga ccgaggacac caatgcctgg tggccctggc gcaggccagc
     1141 gctgcccggg gcgcctggca gggccgcacc ggcgtcgagg gcccacctct cgatggagcc
     1201 gtccgggccg atggccacga aagtgtcgtc gggaccgaat ccggccgtgg caccgccgag
     1261 gggcccggtc ctgcggctgc tgaggagctc ctctcccagg cccggtcggt gggttcggga
     1321 atcaccgagc tggttcagca gctcgtaggt gaacgccgca gcgtgccgtg ccgcggcggg
     1381 ctggcgcacc ttgtcgttct ccctcccctt gtcgacgagg aggtcggaga tgccgcgtac
     1441 gacgagcgca ccgactccgg agctgatgtg cgcgccgcgc aagaatccgt agccctccat
     1501 ctcgacggcg agggcgtcgc ccgcgaagtc gcggaggtac tgggcggtgg gcgattcggg
     1561 gtcggtgacc agcttcgatc cggccgcgat gggcttgacg tatgcctcag ggaggcaggt
     1621 cggcgctggc ccctggatcc gggcctgcca ctccttctcg ccagccacca cttgggcgcg
     1681 ctggatgagg tcgtgggccg gggggaaggt ctgcatgcgc gggcgaaccc cctctgggcc
     1741 gtccacgccg gtctggtagt cgtagacgtg gcggccggcg acgacgtcgc cgtgggtaac
     1801 gtccttgagg ccgccggcga tgcccgtgaa gaaaacgtac cggggtgaga gcgcggccac
     1861 ggccagcgcg accagggctg ccgcgccctc cgctccagga ccggtctcgt gcagggcgac
     1921 ggtccacctg gtgtgcctgc cgacgaatgt gcccagcttg aagatgctgc cggagacgac
     1981 ccgttcggtg atcggttcgt cgagatgttc gcgtgccgcc gccgtctcct cgggcagtgc
     2041 ggtgaagatg atgacatcag ctgtacggtt catgacgtgt ctctcgattc ggccggcgtc
     2101 acgaggcgcc ggtgcgcagg tccgcgtatc tggctatctg cacggcgagc aacaggatgg
     2161 tgagcgtctc ggcgaacgag gtgcccagca gggccgggtg actgggttcg ccggcccagt
     2221 acacggcgag tgcggccagg ggcgcaccgc agaacgccag taggtcagcg ccgagttgga
     2281 gccgtttgcg gttcctgcgg tgggcgtcag agcggtgcac ccgctcccag ccgaacgcct
     2341 ccgtgaacgg gggcgcggcg gctgggggcg ccggggcggt ggcggcggcg gcagcggcct
     2401 ccaggtgggg ggcggtgtgc tcccgtacgt agcggccgat cgcggagatt ttctcgtcgt
     2461 tgaccacgta ggtccagccg agaatgacgc acaccggcgg catcagcagc aggagtccgg
     2521 gacgggaggg gccttgcaga acggcggcga cgatcgcggc catcgaggcg agcgtcacgt
     2581 agagcaggtt gtcgcggaag ccgatgcgtg cgcgctgctc ggccttgagg tggtcgtact
     2641 cgacgagcag caggtggctc gccgtgacgt tctcgatgtg ggacacaaca ctcctttgcc
     2701 gaagggtcgt tggggatcgt gccggtggtt gctcaccggc cgcgagagct ggcgtcggcg
     2761 ggcgcgtcat gtgctcgcat cgctcggcga cggccctcgc ccggaggggg aggcgcgcct
     2821 cacaccggtc tcagatctcc gatctcagga ctcgggtccc acgtctcacg tctcacgtct
     2881 cacgacatcg agatcgtcgc gtcccccaag ccactgaccg ccgacgtccg gtccgggtcg
     2941 cccgacctga tcagcgtgca ggtgatcttg atctggtcct ggtccgtgat gtcgaccgcc
     3001 agttgtccga cggcgctgga ccgaacggtg accggttcgc ccatccggtt gccggacgcg
     3061 ttgaacacct tgatcgagcc gaccgacgcg atcgagttgc cagtgtcggc aggcaggccg
     3121 accgtggccg tcaggcgctt gtagccgctg acgttgtaca ccgcctcgtc gctgctggag
     3181 gtgtcgcagc cgatgcggat gctcttgggg tagttggtgc cgcgcatggt cacgggtgag
     3241 gtgttgacgt agccgcggtc gctcactcgg tccaagtccg ccaggtacac ctctgcgggc
     3301 tgaggggact cccctgtccc gccgtcgatc ggttcgcccg tcggcgactc gctgccgccg
     3361 tccctcgtgg gcgaggacga cgaccccgac agtggtgtcg gcgacgccgt gactgtctgg
     3421 gtgacagtga cggtgacggt cggcgccggt tcggcccggt cggaggacga gccgacgtcg
     3481 ctcgcccgtc ctccgacaaa cccggtcacc acggtcgcca caaagaccac agtcagctcc
     3541 acccaccgcg gaccgaagtg ccagcgcgac cgcttcggcc tgtcccgctc cttcttactg
     3601 aggtccatct caccccttgt gctgcggact cgcgtgagcg gaacgaacag gcccctgagg
     3661 gcgattggtt acctgggagt aagcaggatg ttgtcgtcgc acgcgcatga aggcgactca
     3721 cactagggcc ggtccgccac acatgcgcga caatcgctcc cttgacccca gcgatggaag
     3781 cacgggtgca gaactgtgtt gtgtgggcgc cgagttggcg ccccttgcgc ggatatgtgc
     3841 gccccctcgc gcgggatgta tgcgccccct cacgcgacgt acgatcaccg acccgatgcg
     3901 cgctaggggt tcgtttggat caccgtgcga accaccgtgg aggccctcgg catagaaccc
     3961 ggccaggtag atcgtggctg tcctctcata gcgcgttggc gatgccgcgc gttcaccgcg
     4021 atgcggcaaa ttgcggcgcg tcgcggggcg tggccgccac agccgaacta cagggaccga
     4081 ccctcctgca ccatgaccca ggtcacagac ccgggcctgg tgggttgttc aggacgcttt
     4141 ggcgcggcct ttggcgcgac ccggctgccg tagtcttccg ccacggtcag cggttgtcgg
     4201 agaaggggcg cagggtgatt cgggtcgtcg tcgtggacgg cgagcagctg gtccgttccg
     4261 gactgaagtt gatcttgagt tccgccgggg acatcgaggt ggtggccgac tgcggcggcg
     4321 ctgaggccgt cgaggccgtc agggcccacc ggccggacgt gctactgctc gacatccgga
     4381 tgcctgacgt ggacggcctg acggtacttc ggcaggtcac tgccctggag tcggcgccag
     4441 gcgtggcgat gctgaccacg tttgacgcgc gtgagtacat cgacgaagcg ctgcgcgcgg
     4501 gggcggcggg attactgatg aagaacaccg cccctgagca actggtccat gcggtacggg
     4561 tactggccgt cggcggcagg attctggcgc ccgaggccac gagcgccgtg atcgacgggt
     4621 acctgaccgc cagccgcgag atcgaggcgg cgcgaagcgt ggaggcgctg accgtacgtg
     4681 agcgtcaagt gctggctctg gtcggcgcgg gcctgtccaa ctgggagatc gctcgtcggc
     4741 tgcgcctgtc ccacggcacg gtcaaggacc acgtcagctc gctgctcgcc aagctgggcg
     4801 gagtcaaccg cgtccaggca gccgtagttg ccgatcgcgc gggcatggtc ggtcggcgca
     4861 ccggcgggtg aggggtgagc ctgggctctc cgaccggggg cgcccgctca acggatcgcc
     4921 cacgcgatcg cgggagacgg ctgcggcagg tctgcgtgga ggcgggtttc agggctgcgt
     4981 cgtcttccgg tctggcggtc atccggcagg ccgggattcg attcccgctc attccgcgga
     5041 aggagatctg tcgcgccgac ccccgccggg tggcgggggt cgactcccgt cgattagccg
     5101 ggcatttccg tcaatctcct tggagttacc tgtcagttgc gaccccttag ctgcgaaagc
     5161 taggatcggc gggcgttgac atggggcgcc aacaggcgcc tgtacggggg aagtgcaata
     5221 tgagggatag cgaagacagc cctacgacca ttgggctaat tgtcgcgaga atgtcactgc
     5281 ggcgaaggct gaagcgtctt ttcgccgggc gaggttggca ttccgtggag gtggagggcg
     5341 gcccggccct tacaccgtgc gatgtcctgg tcgtggacat cgaccgactc gaagaggtcc
     5401 acgacccggt gccggtcgcg gcggtgacct acggcgccga gatgcggcac cccggcctcc
     5461 tggaggccga tgtacgcgcc atcgtggacc gggacgacct tgacgacgct tttctggagg
     5521 ccgtgcacga ggtcgccgcg gggaacgggt ggatctcgcc cacgcttgta cgtccactgt
     5581 tgcgcggccc acacaccgcg cacagcgcgc acagcgcgga agccgcgcag cagcccgcgc
     5641 acaccgcagc gcgtgtccgg cggcgcgatc cggcgctcac cgcccgcgag tacgaggtcg
     5701 tgtcactggt gacgcagggc atgaacaaca gcgagatcgc cggagccctc tatatcgccg
     5761 agagcacggt gaagttccat atgtcgaaca tcctgcagaa gaccgggttt cgggaccgga
     5821 gccaactcgc ggcacgcgta cccacacgcg tacccgcacg cgtacccgca cgcctttccg
     5881 tcgcccgata agcgacaacg tacatacgta tacaaggcgc gagacactag acactagaca
     5941 cgagaaagag accgttatgg ggaacaagaa ggaaactctg cgctgggccc cggtggcgat
     6001 tctgctggtt ctggcgatca tcgccccgct cttcggggac agccccaccg ccgtggtgac
     6061 cccgctgctg ctcgccatca tcctggccag cgccaatggt gtgcagctga agcgggaacg
     6121 ggccgcccac gacgcgggct gagaagccga ccggccgccg gggtgcgaac gccggcggcc
     6181 agggggtcag ggggtcaggg ggtcaggggg tcaggcgacc tcgtagcgcg cgaagcgcag
     6241 gccccccagc gcgcccgtca cgacggcgta cagggcgagg accaggaatc cgagtgcctg
     6301 tggcgcgccc tcggcgtcgg ccgccgcggt catgatcgtg ccgccaccgg cgatctcccc
     6361 ggccccaccg ggcagcaggt tgcccaggcc cgggctgccc agctgggagg cgagaatccg
     6421 cagcgtcggc tccaggaact gggtgaccag caggatgccg acgatcgcga cgacctggtt
     6481 gcgtacgagc gcgccgacag ccacgccgat cgcaccccac agcgtcatca ccagcacgct
     6541 gcccgacagg gcgccgagca ccgggccgtc catgaggtac ggggattccc cgtgccccga
     6601 cagcagcgcg gccgcgacca gcgcgctcgc gcccaccgac gcggccccgt acacgaatgc
     6661 cgtgccgaga ccgaccagga ccttggcgcc gtacacccgc atccggcggg gctcggagag
     6721 cagcgtggcg gtaatggtgc gcgagttgta ctcctgggtc accagggcgg tcccgatacc
     6781 tagcgggaag acataggcga gcgcgaccgg gaggttgtac gcgggtacga cctcgtccgc
     6841 cgagtcgaaa cggagcggac ttctgggggc gttgaggccg ccgaaaacga caagcgccgt
     6901 gagaccggcg ctgcacacga ccatggtgag cagcagaatc caccacaacc tggtggtggt
     6961 gagcttccgc agctcggttg agacttgcga gcccagcgag agttgcgagt ccagggacac
     7021 ttgcgagccc agcgagggtt gcgagcccat actcgtcttc atgctcgtcc tccgattccg
     7081 gcctgtgtaa ggcgcataaa ggccgactcc agacgctcgt ccgtctccag caggccgcta
     7141 agcggttgtg cgcagagcag tcgcccgtgg tgcatgagca gtacgtcgtc gacgatctgc
     7201 tccatctcac cgagcaggtg gctggagagc agcaccgtcc cgccccccgc ggcgtacgag
     7261 cgcaggaacc gccgtagcca cagcatccct tcggggtcga gaccgttgct cggctcgtcg
     7321 aggatcagca gctccgggtc gccgaggagc gcggtggcca gcgagagccg ctgtttcatc
     7381 ccggtcgagt agccagagac cggacggtcc gcggcccctt cgaggccgac gtccgccagc
     7441 agccgcgcga tccgctcggg tccacagccc gcggcccggg catagcagcg caggtggccg
     7501 cggcccgttc gtccgcccag gaacgcgccg ccgtccaggc cgaccccaac cctgcgggtt
     7561 ggcgtgggca gttcgccgta cgggcggccc cagaaccgcg cggtgccctc ggtgggccgg
     7621 atcagcccga gcagcatgcg cagcgtcgtg gtctttccgg ctccgttggg gccgaggaag
     7681 ccggtgattc tgccgcgcgc cacatcgaag gagacgctgt cgacggctct cgtaccctgg
     7741 aactccttcg tgaggccccg gaccgagatc acgtacttct cttcctccac ctgcttcaca
     7801 tctcctcatc tcctcagtac gtctcgcggg gcggcgttcg ctcagaccgc gctcaggtcg
     7861 acctgcgagc ggatcagctc ccggtacagg ccggattccg ccagcagttc ggcatggcgt
     7921 ccggtctgga ccacccggcc gtgttcgaga acgacgacga ggtcggcgct gacgatcgtg
     7981 gacagccggt gcgcgatgac gatccgcgtg cactccagcc ggtccagcgc gtcggcgatc
     8041 ctggactcgg tgacggtgtc cagcgcgctg gtcgcctcgt cgagtacgag gacgcgcggc
     8101 cgccgggcca gcgcacgggc cagggcgatg cgctggcgct ggccgccgga gaggctgccg
     8161 cccatctccc gtaccggcgt gtgatagccg agtggcatgg cggcgacatc ctcgtggaca
     8221 tgcgcctcgc gtgcggcctc gaccaccgct tctatggtgg cctcgggaac gccgaagcgg
     8281 atgttctcgg cgatgctgcg gttgctgagc acgatgtcct gcgggacgta cgcggtgttc
     8341 gcgtagaacg tgtccgcgtc gatctcctgg agcgatactc cgtcgtaggc gatgtctcct
     8401 gactggatcg ggtacagccc catcaggagc ttgcccaggg tgctctttcc cgagcccgag
     8461 ctgccgacga tcgcgacgcg ctccccgggc cggatgtcga acgagatgtc ccgcagcgcg
     8521 ggggtcttgg cgcccgggta cgtaaacccg acctcgcgca gcgagaccgc gccccggatc
     8581 gccacgggcc ggtcgccgaa ggcgcccctg gactcgggct ggtggaggat gtcgccgacc
     8641 ctggccacct gcgtgttcgc ggtgatcagc tgggtgaaga caccggacag ggacatcacc
     8701 atgcccaggc tggtggcggt gagcgtctgc gccgcgaccg ccgaaccgag gtcgagcgaa
     8761 ccgtccagga ccagccacaa ccccacggcc agcaccagca gcggcccgaa cacctggaac
     8821 acggagtagc cactggacgc cacgccctgg aggacgatcc gccgctgggt ctgctccatg
     8881 cccaccgagt acaccttcct ccagtcgcgg aagaaggtgt cggtcatgcc ggagaccttc
     8941 agggtctcga tcgatgacag tgcttccatc tggagcgagg aggacttggc ggtctcgctg
     9001 atctcccgct cggtgacccg gcggagcggc cggtacatgc acacggcgac cgtgagcatg
     9061 gtgagaaaga tggcgaaggc ggtggccccc aggatgaacg agcggtggaa catatagccg
     9121 aagatcacga tcagactgcc gacatcgagc aggacggccg gcagttggct ggagatcatg
     9181 tcccggacgg acgtgatgct ggacagccgg tagaagagct cgccctgtga gcggttggcg
     9241 aagtacttgt acggcagatc gagcagtttc ctgaacgttc tgcccatcat cgcctcgccc
     9301 aggccacgga tcaccgcggc caggcacacc gtacgcagca gggagaggac gaaatagacc
     9361 gccatcggga ccgtgaaggc cagcaggacc agcgcgatcg gcgagttctc caggtatccg
     9421 gcgtagtcgt tgaccgcgtg ctgggtcgcg atcggcatga agatggtgaa cgaatacagc
     9481 accagcgaca tcacaaacgc ctggagcaac ggccgtcgcg ccccgctcag cgaccgcagg
     9541 aactcccgcc acacgctcgg ctcacggtgg cgcaccggct ggtggtcggc ggtgggcgtg
     9601 gcttccaggg ctagccccga gtagtgccgc tcgaactcct cgaccgggta cttccgccgc
     9661 ccggcggccg ggtcgacgac ggtgacatgg cggtcggtga tctcctccac gaccacgacg
     9721 tggctgtcgt cccagtacgc gatgagcggg agggccagcc cgtccaggcg gttggcgccg
     9781 gcccggaagg cccgtacctg gaagccgcga ccgcgcagga tggtcgctat ctccttgatg
     9841 gtgagcccgt cgcggcccac ctcgtgctcg cgccgcagcg cggcgaccga gtcgcgtgag
     9901 ccgtacgcgg acagcaccat cgcgatgcag cacaggccgc attcggactg ggcgaactgc
     9961 tggacctccc ggactctgcg agcccggcgg gtacgcaccg tcatgagcgg cctccgaggc
    10021 agcggggaag ggcggcttgc gggtggtgca gcatcagtcg cgcgtagtgc cagccggaga
    10081 ggccgaggaa gaaggaggga aggtgcggct cggtcccgat gccgcacgac cagccgccgt
    10141 cggccgccgc gtagcggtcg aggaaggcgg tgtgcaacgc ggcggcttcg tcacgcagtt
    10201 ccggccagtc gaaccggtcg gccagctggc acaggacggc gatccggccg gccaggccgt
    10261 ggcagaagct gatgtcgtgg ccgagatcgc cgtcggccag ccgctccacc tcgggtgcga
    10321 tggcggtccg gacgcgcccg gtggactcgc cgagcgcggt aaggagttca ccggccgcgt
    10381 acgccacacc cgcgtacccc ttgcaccagc cgctgccgct cgcccggtcg cgcagactct
    10441 cgtcctgcca cctgttccgt acgtaggcgt gggcgaaccg ctccaggtgg tcccgggcgc
    10501 cgctgccgcc gtcgaggccc tcggcgacca tcgcgctcat agcggtgatg cgtccgaacc
    10561 ggccatgcgc gaggcccagt tcaccggtgt gctcttccgg ggtgccgtcc acggtgacca
    10621 ggcgccgcag cagccgctcg ggcgggacac cggtcagctc gggtgcaccg tgcttctggt
    10681 aggcggcgag gtagacgagg tagccgccgt acccgttgag gtagtcgaag tcggccgcgg
    10741 tgaggctgtc gacatcgagg ggacggtccg cagggtggag ttccgtatgg gtgaagaggg
    10801 cgtcgggcgt gcggcggcgc cggatctccc agtcggtgac gagttcggag agggctcccg
    10861 tgaacggcga catcgccagc ggtgtcgtgt cacccgcgaa cggcggctgc ggctgcggct
    10921 gcatggcggc tcgggagacc tgtgcgatgt ccacaccgag cggcgatgtg ccggtgagtg
    10981 cctcggcctg ggccagatag aggagcaggc cgccgccgtc gtagagcggt gcgttgaccc
    11041 cgcccaggcg cagcccgtcg cctcgcagtt ggggcagcag ccaggtcggc gccgactcct
    11101 cgccgacgac gaggtcacgg agcgtgctgt gccaggccgt ggcgtcggcc aggtcgggga
    11161 acacctcgcg gcgcgatgcc cgccgtacgt cccagacgtc gtcaacggag ccggcgaggg
    11221 cgtaccgcag atagctgaga tcccgctgcg gcggccgggc gaagaaggac cggacagcgg
    11281 ccagcgcggc ctcccgggga gtgctgtcgg cggcgctgcg catctcctcg tccagatcac
    11341 cccgcagcag accggagtcg cagtccaccg tgaagaacgg cacgtcgaga tcgagcaggg
    11401 cggccacctc ctcgcggtgc agcgcgtccg ccgactcctt ggccgcgccc cggtagtacc
    11461 ggggcagctt ccccagcagt tcggctcgtg cctcggtgct gcccaggtgc acggggtggg
    11521 tggaggcctc caggaagcgc gcgtacacat acgtcggccg tacgacctga cgcaccgccc
    11581 agtcaccgga agcccgtacg gccgcttcaa tggcgtcgcg gagggtggcg agcagttcgc
    11641 gcgcctcgcc gtacccggcg gatatctcgt ccacccagtc gcgggggtcc agcggttcgc
    11701 ccgccacctt ggccatgttc gagccgtgct cgacgacgac ggggctgcgg tcgaagcgga
    11761 tgtcgtccgt ccccgcgtcg acaaccgtgt acgacgtgag gtgctcggag gctcccggcc
    11821 gcacgcagcc gattccggag atgtcgatgt ccagcttcgc gcccgcgtaa cgggcgggaa
    11881 agagcagggt gttgagcacc gagtgctcga tgtccaggtt gagcgcggcc cccgctgacg
    11941 ggctctgcgc cgacgccgac gccgacgccg aggccgacgt gtccgtgggg ccgttgggca
    12001 gcgataccag ggtctcggtg tcgatcacga cggggccctg gggtacggcg atgatgttct
    12061 cgtggtgcag atcggtcgca ccgatcatgc tgagcagcgc ggcgacccgc ccgaaacgcc
    12121 ggaagtactg ggcgccctct gtgacatcgt cgagatccgt gtgctcgatg aactcctgcc
    12181 acacatatgc cgaccggacg agcgacctcg ggtgcagcgg gccgaagaac gagccgtcct
    12241 cgtcgaggag cgtgcgcaac gtcgcgagca ggctctggca gttgtcctgc tgcggcttgt
    12301 acacgacccg cgttccgtcg ccgaaaccca ccaggcagac cgtgcggccg ccccggtggg
    12361 cgtcgccaag gccggtggtg agcgaggtga cgggcccttc agcgcccagg agttcagcga
    12421 gctgccgccg gtccgcggcc agggcgcgca ggacctcgcg ggcggtccgc gcggtgcggg
    12481 cggtgaccag acgcagcagc cggtccagtt cggggaagcg ggcgagcagc gcgccgcggc
    12541 cctccgcacc ggcgacccgg gcgtggaacg cctcgtacgt cccgccctcg gcgcggaagg
    12601 aggcgatgag ggtccgtacg ccggtctcta cacagacgcc catcagcgag cggagtacgg
    12661 actcgacgac gctctcggcg tcgacatcag catcggctgc gtcggctaca tcgcctgccg
    12721 cgtcggctgc ctcggctgct gcctcatcca ggtacccggc gatctgccgc gcgcagtccg
    12781 tcaggtacgg cgtgtagaag gcgccgaaga catcggccct ctcctcggtg acgcgcttca
    12841 ccagctcttg ggggtgcact gtctgcactg tctgctctcg gatcgtggac ggtggtggga
    12901 gggtgggggc gggtgccccg gaagtaccgg ttccggggca cccgttccgc gccggttcag
    12961 cgatcagcag cgcttggtgc acccgctggt cgggcagccg ccctgcagcg cggcgctagc
    13021 gccgacgatc acgccggtgg ccggaaggat ggtgggcgtg atgcccgcgg ccagggactc
    13081 cggcgcgtcg gcgagctcga caagctcgtc ggcggagacg taaccggtgg cgtcgttcat
    13141 ggcgatgttg cccatgaggg ttcctttcac ttggtggtgc tcttctcggc aaggcccctg
    13201 acggggcctc gttcgtggtg cgctaggcga agcgcaggag ggaggggtag ccctccgggt
    13261 ccaggtggtg gagtacggac caggcgagtc cggcctcccc gaccatgagg ctgttgctgt
    13321 acgcgtactt cgtgtcgcac cgctgctcgt acctctcgac gacctcgccg aagaggcgcg
    13381 gatagaggtc gtcgatgccg ccggtgtcac cgaacacgcc ggtgtcgtcg aacacgccgg
    13441 ggaggcgctg tgcggccagg gccacgactt ccgcgctggc caggtcgccg tggcagtacg
    13501 tcgggttgtt gccgaagccg cggctgacgg tcagctccgc gagccggacc agcacggcgt
    13561 cgggcacgga cccggtcgcg tactccacgg ccgtcaggga gccgagcagc aggccgggcg
    13621 cgccatggca ccagccgtac gagcgctccg gctcgtccca cacccgtggc cagtcccggt
    13681 cgctcgcgtc ataggagtcg agcaccgcgc cggtgatgcg caggccgagg tcccgcaccg
    13741 gcgcgtcggc gaactcggtg ccgtaccgga tgagtacggg accgatgccc atcgcaccgt
    13801 gggcatagcc ggtgtacgac gtgacccggg cgtcggccgt gtcgcgcagg ccgagatcga
    13861 tgccgcccag cgcccgtacc tccgcggcgg ccacggtcgc cgccgcctcg gccaccgcac
    13921 gcttctcggc gggggtcgtc gcccgctcgt gcagggccag ggtgacggcc agggccccgg
    13981 cgaggccgct cacatagtcg gtgccgacct cgggacccga gctgcgggcg agctcccgcg
    14041 ccagctcgcc ggcgcgcgtg ccgtccggct cgtccaggag gtcccgggcg acggcgaggg
    14101 catacgcggt gccggccagg ccggtcatac cgccgacgga tacgccctgt tcggcgagtt
    14161 gaccgccgcg caactgctcc tctacggggt cgaggacgcg gcgcgcggcg tccgcgaagt
    14221 cacgccgccc ggtctcccgc gccaggccgg ctaggaccag ggcggggccg gggctgccgc
    14281 cgtagaggtc gtagccgagg gtgccggggc tccactggct ctgtgagtcg gtggtgacct
    14341 gcggggcgat ccacgtcgcc gggtggcgtg gatcggtgct cgcgatcagg gtcgccagca
    14401 gccggtcgcc gatgcgctcg gcttcggcca ccagccgggc gcggctgacc gccgcgggcc
    14461 tgtccgccgc gggcctgtcc gctgcggggc tgaccgctgc ggggctgacc gctgcccgta
    14521 cggggacgaa gcccgtccgc tcctggtccg tcggcagctt gttgacgaag gagtagtcga
    14581 tcagccggag ttcacgggcg atgacggcct cgtcgagacc gtgcactcgg gcgcgtacgg
    14641 tctccagcgg cggctcggcc agggcgtccg cccggaccac ccggccaccc gcgtacagag
    14701 cgcggccgcg ggcggagtag gagaagtacg ggacgtcccc ctcggccatc tgccgcactt
    14761 cctcgtcggc gagcgcgggg ttgtcaccgg tgcgcaggac aacccggttg aggaccgcgg
    14821 cacggaccac cggatcggcc atcgcgtgcg ggtgagtcgc catgcgcagc agctgcccgt
    14881 agaagatcgt cgcctggttg acgtgccgga accgcgcatc cccgaggaac gtctcgatgg
    14941 cctccatgac ggcgtcaggc tgagcggccg cgtactccag gacccgccgg aattcggcct
    15001 tgatgatgtc ccgttgggcg gtcacgggca gctcggtggc gcgctgcacg acgaggttcg
    15061 cgttggccgc ggtggtctcc gtggtcacca tgccgacgaa catgtcgtcg cggccggggt
    15121 tctggaggct gagtgccttg tacggggcgc gctggcccgt gtcgtagccg atggcaccga
    15181 tatccatgcc ggggtccttg tcccccgccc tgacgacgag cggcaacagc ccggacccga
    15241 tgaccgagtc ctgaagggtg agcgccccga gccgggacgc cgcgccgtcg tcgtacgccg
    15301 cgggaacggt cagccggggc gacagcagcg tctcggtgtc gatgacgacg ggcccgtcgg
    15361 cgcacgacac catgttctcg aagtggatgt cggtggcctt gaggaggaac aggatgccgc
    15421 cgatggcacc gatgcgggcg aagtagtcct tctgctcgcc ggcgtactcc tgcgtgggga
    15481 tgaactcgac gaacccgccg tgctcggtgg gcaggacgga gacggtgggc agatcgttgc
    15541 ccagccggtc gttcatccag gagacgaagg agctgtagcc cgcttcggcg tccatggggt
    15601 gtggcttgta gagcacgcga ctgccgtcgg tgaagacgat ctgggcgacg gacttgccgc
    15661 cgttgtgggt gtcgccctca ccgagggaga gccgctcgac ctccagaggc gcggaacggc
    15721 cgtcaccgcc gcggatcacc gcactcaacc cggctcccgc gacctcgatt tcgcggagta
    15781 cctcgcggac gtaccgtgcg gacgcctcga cttgacagtc gaccaggtgg aagaggtggg
    15841 ggtacctggc gagcagctcg ccgtgcccct cgtcgctgtt ggtccagcgg cggaaggccg
    15901 cgtaccgctc ctcgggcgtc tcaccgtcga ggagaccctg ggagcggtgc cggtggagct
    15961 cctcgaccag ggtccggacc atcagacggg agacgagacc cgtctgatga gccagaaagt
    16021 cgtcaatgac agtgttgttg tcggtggaaa cgacagggga cgacgcgaca gcggcgcgga
    16081 cctgctccgc ccagggctcc acgaagtgcg cgaagtagtc atggaagagg ccgtcggagt
    16141 cgagtgacgg gtcatatccc gagggccgcg cgggccgccg cctcttctca tcctgcgcac
    16201 cgtcggcggc gtgggcggtc cgcagccgct cctcggcatg ctttatgagc tcgggtgagg
    16261 tcagctccgg caggtacgtt cgcagcgctt cggctatgtc gggtgagtcg gctgaatcga
    16321 cgtgactctt catgaacacc gggtccaggg cagggagatg gggtgacgcc gggatggggg
    16381 atcccggcgt cattcggtca ctggcagttg ctctggcact cagcggtggc agtgcagaag
    16441 ttcccgttgt tccccaggac gtagctggcg ccgtagcagc tcagggagga cagggtcgtg
    16501 ccccagccct ggcccgcggc gctgacggcg tcgaggttct ggtcactgat ctcttcgagg
    16561 attccgacgt tggcgttcgc catctggccc tcacaccttt cacacgagag aacggcctgg
    16621 ccaaggccag gccgtcccgt actgatcttg acgaccagaa cgctaggcat gtgcgccgcg
    16681 agataccccc gtccagggac gggttccgcc ccgtaccagc ggcctgctcc acacgccggg
    16741 aggggaggtc actcccgcgc gacgtcgctc gatgttgggg gccagatggt tgaacatcgg
    16801 cgatgggctg gacgcgggag acgttgacga gggcggtcag gaagccgtcg agcagatctc
    16861 cgtgttcatc gcgatctccg gtgaagcggt gtcgcggtgg ccagggcctt ggagtgggtc
    16921 gccggatcga agtgtgcgga gccggtgttc tgggcgcgcg ttcgatgggc tcggtgaggg
    16981 gcgcggaccg cccgggtccg gcggggtgtg ccgggcccgg gcgggtggcc gggttagagg
    17041 gagagagtcc aggtgtcgag ggtgcccgtg tcgtaccggg cggtgtcctg gacgcggagc
    17101 gaccaggtgc cgttgcgcgc ctcgccggac aggtcgaccg tgtaggtctc gtggatgtcg
    17161 tcggcgctgt ccccgccgct tgcgctcttc agcgggtaga cggtgccgtc gggggcgatc
    17221 aggtcgacgg tgaggtcacc gcgccaggtg tgctcgacgt ggacctcgac ggtactggcg
    17281 tccgacgcat tgccggtgca gcccgagatc tcgatgccgc tggtgacggc tgagccgttg
    17341 tcggggatgg cgacgttcgt cccgttggtg gcgctgcact ccgagggcgg gggtgtggtg
    17401 ccgccgccgt aggggttttc ggcgtgctcc gccgcgtaga ccagcatggg cttgacctgg
    17461 ttccagaacg tgtcctggca ggagtagctg gggtggaagc ctccacagga gccgccggag
    17521 gggccgacct cccaggtgaa gctgggcacg ccgaggtcgt cgtaggccca gtcgtcgtgg
    17581 gtgccgctgg cgttgtagag gatctcgcca ggctgtccgt actgccagcc gcccgccagg
    17641 ttcgccatgt ccttggccat ggtgcgtagc gcggcgtcgt tgccggcgtc gatggaggag
    17701 ttgaatcccc aggggaacag caccatgttg gagtagctgt gcatggagac gaacatgccc
    17761 tgggtgtcgg ggtcggcagc ggcgttgtca ccggcggggc gggtgtccgg gaacaggtca
    17821 cggtagaggg cctggagggc ccgggtctcg gtctcggagt ccgcggaggg ccccttgtag
    17881 accttggagc acgggttgga gctggtaccg gcgccgcccc agtggctgcc gttgttgcgg
    17941 ttgaggtcga tgccctcacc gccgtaggag ccctcggagc atccgctgct gtgggtgtgg
    18001 ttggagttct tgcggtgcca ctgctgctgg ctgggcccgc ccgtgaagcc ctgctggacc
    18061 atgtcgacgc cgtcggggtt gccgatcggc acgacccaga tctcccggtt gtccaggatc
    18121 tcggtggccg tcgggtcggt gccgtagccg tcggtgaggt agtcgatcca gcgataggcc
    18181 atctcgccgg tgctcaactc ccgggcgtgg acctgggcct ggacgaggag ccgtggtttg
    18241 gaggagtccg ggttcagctg gcagtcgccg gactgcttct tggtgatgca gatggctttc
    18301 aggtcgtagc cgttcggccg gccggtggcc ttgcgccagg agtcgccgac atcgaagacg
    18361 gtggccaggc cggagtggtc ggaggcgacc tggtccaggt gggcgtactg ggcgttcacc
    18421 gtgcggtagc cgccgtagta ggtctcctcg gcgaccttgg cggtcagccg cggggcctgg
    18481 ccactgcgct tgggcggccc ccagggggct gggctcagcc gctgctcgac ggtggcctcc
    18541 agcccggcgg ccttgaggtc cttggcggtg ccggcgtcgc cgaggacgaa caggtcgtcg
    18601 ccgtcgcggt cttcgatcag gtcgaagccg gcgagcctgc tgtccgccgc gtgtgctccg
    18661 tcgtggacgc ggtagacgta ggcgcgttcg tcctgagccg atgcgggtct gtcgggtggc
    18721 ggggcggcgg caccgtagcc ggtgccgact gccagcgcgg ccgtcgtggc ggccgcgacc
    18781 agccagaagg tcattttcgt acgcacgtga acctcattca gtgggggtag cggtcggtta
    18841 ccgccgtatg acgaggtggt gcctggcgac tgtagtcatg gacatgatta gcaacagctg
    18901 ccggatctgt gaatgcgcct gcgcttccga tcccggacaa tgaccgattc cgacgccacc
    18961 ccatcggcac ggatggcgtg aaacgcactc ttgacgggga cttgagcgcc aatcagtttc
    19021 ggccgtgccg agaacggcgc gcgcctgggg cgagacggaa cctcacagca ggcagcgtgc
    19081 gtgagccccc gccgccagag caggaaaccg gaccggaccg ctcacatcgc cgactgggcg
    19141 aggtggagca ggccggtacg catccgctgt tcgccgagtt ccggcaggag cgcggcgacg
    19201 tggtcggccg ccagcgcggc gagcagggcg tgggcggcat ggtcggggtc ggggtcgggt
    19261 gcggtggcga gcaggatcgc cacgtgacgg tgccagaacc ggtaggcccc gatccggtac
    19321 cgggcgccgg gggtagcggt ctcggacatc cggaccagcg ccagatgctc cagcaggtag
    19381 tcgaagtagg cgttgaggaa cgcggccagg cgctcgtcgg cgggagcccc cgggcccaat
    19441 gggggtgggc cgtacaggat cgcttcctgc agcacgcgct cgcgggcgtc cagtagtgcg
    19501 acggccagcc ccgacttgtc gccgaagcgg cggaacaggg tgcctttgcc gacgccggcg
    19561 gctgcggcca cctgatccat ggagaccgcc tcgacgccct tctcggcgaa cagcctggcg
    19621 gccgcctcca gcaccgcggc ccggttgcgg gccgcgtccg cgcgctcctt gggcggcggc
    19681 gtccgcagca gttccagggg cattgccgaa acggaccgca gtccgttact gtcgtgagcc
    19741 ataagaggac tgtagtccga tttccttgga ggcagcagca tgaccgcact catcacccgc
    19801 gacgagctgg cagcggcgat caaggccgag tccgtgaccg tcgtcgacgc gctcggcggc
    19861 gcgtactacg cccagcaaca cctgcccggc gcgctggcgc tgatcccggc cgacgtcgac
    19921 gctcaggcgc ccgccctgct ccccgaccgc gacgccgcga tcgtcacgta ctgctccaac
    19981 ccggcctgcc ccaacagcgg acaggtcgcc gaccggctta ccgccctcgg ctacaccaac
    20041 gtccgcaagt accgcgaggg catccaggac tgggtcgagg ccggactccc caccgaatcc
    20101 gcctgacctc gcctggcctc gcctggcctc gcctggcctc gcctcagtgc gaacgcccag
    20161 agcggcgccc ctgaagcgcc tgtccgcgcg agttcccgat cagccggaag cgagcggata
    20221 gctgtgcgcg atggccgtgc gcgatggcca gtcgccggtc gggcaggtac gcctggccgg
    20281 tagccgcatc gtggccgacg gcccggccga tgaactgtcc cggcaggcgt cggccgaggc
    20341 caccgtgcgc tggacgcggg acggtcggcc cttcgagcag gcgacggccg agcccacccg
    20401 gttcgtccgt cggctgttcg aggagcacgg agaggcgatc gacggtcttg aggtgcgccg
    20461 ggcaagcctg gaggacacct atctgacgat ggtgcgggag ctggaggaag cgccggggag
    20521 cgtcaggtac gggcagacgg cgcacccgtt cgaggaggga gcgcgatgag cccggtgtgg
    20581 tacgcggcca gaacgggggt gcggcgcggc tggacggagc tccggcagac cttcaccacc
    20641 ggtcaggacg tgttcgggta cgtgatctgg acggctctgc tcatcgtgcc gctgttcctg
    20701 ctcagggacg atccgctgaa aggcgccggt atctcggtcg gtgcgttcat gctgccgagc
    20761 atgctgggga tgacgctcgc cttcaccggg atgatgacga cggcgcagct gctggcggcc
    20821 gagcgcgagg acgggaccct gctgcggggc caaggccgtg ccccacggca tggtcggcca
    20881 tctgatcggc aagatcatca tggtgtcggg tacggctctc gcctccatgg cactggccct
    20941 cgccgccggg gtgttcctgg tggacggtgt ggcccggcag ggcggcggag cgtggctgac
    21001 gctggtgtgg gtggtcccgc ttggcctgct ggcgaccctg cccgtcggcg cgatcatcgg
    21061 ctcgctcgtc gacagcccgc gcaccatcgg gctgttgatg cttccggtga tggggctcgt
    21121 cgtgatctcc gggatctact tcccgctgtc gaagctgccc gagtgggtcc aggtcgtcgg
    21181 gcaggtcttc cccgtgtact ggctcggcct cggcctgcgg tccgcgctgc tgccgcccga
    21241 cgcggtcgcc gccgagatcg gcgagtcctg gcggcagttg gagacggcgg gggtgctggg
    21301 tgcctgggcg gtcgccgggc tgctcctcgc tccgtccgtc ctgcgcagga tggcccgccg
    21361 cgagtccggg tccgcgatgg cggagcaccg ctcgaaggcg atgcagcggg tcggctagta
    21421 agccgggctc gtaaaccggg ctcctaaacc aggctcgccg agcttcagtt cctcgtgcca
    21481 gcggtgcacg acgccggtgt acgtctcgac gccgggcacc gccgcgttgg cgcgggcgag
    21541 cgcgagggcc gtgacggcga accatctggc ctgggcagtc gctcggcggc gtccggccag
    21601 gggcggggcg ccgcgggcgc ccctccctga tccctacgcc gcctggggat gcatcagtcg
    21661 ggccagcagg tcgtcgaggg cgaccatgcc ggtgaaccgg ccggtgtcgt ccctgacgac
    21721 ggcgagcgag gcacggcact cgcgcagccg ctcgatggcc tggccgaccg tgtcctgccc
    21781 ggtcagttcc ggcaccgggc gggcgaggtc ccgggcggtg accgcccggc cccgggcgcg
    21841 ggcgatcagt gcgtcgcggg catggacgga tccgacgacc agcgggccgt cgagcaccag
    21901 caggcggctg cggtcgtgct cggccgctgt ggcgaggatg gcgtccacgt cggcctgggc
    21961 cgacaccgag gtgatccgcc cgacgggcgt ctggaggtcg ccgacgggcg tgtgcggctc
    22021 ggtgagggaa ttggtgatca ggtcggagtc ggcctcgctg atcaggccga ggcgctcgga
    22081 ctcctcgacg aggtgcgtga gctgctcgcg gttgtggacg gacgtgagct cgtcgcgcgg
    22141 ggtgacccgg cacatccgca ccagggcgtt gctgaccttg ttgagcagcc agatgagcgg
    22201 acgtacgacc ttgaccaccg cccggaaggg cggcgagagc agcatcgccg agcgctcggg
    22261 gtgggcgatc gcccaggact tgggggccat ctcgccgacc accatgtgca ggaacaccac
    22321 cacggccatc gcgaaggcga aggcgacgcc gtagctcagc ccgctgggca gtcccacctt
    22381 gtgcagcagc gggtcgagtt cgtgcgagat cgcgggcttg gagatcgagc cgaggcccag
    22441 ggtgcagacg gtgatgccga gttgagcgcc cgcgagcatg agcgacagct cgcgcatccc
    22501 ggccagcgcg gccttggcgc cgcgctgccc ctcggacgcc gccttctcca tgcgatgccg
    22561 cttggcggcg acgagagcga actcggcggc cacgaagaag ccgctggcga tcagcaggac
    22621 gacagtgacg aagagcgcca tcgggaaact catgccagct cctccttgct cgaagcgctc
    22681 ccgttcggag cgctctcact cccggcgctc tcactcgcgg cgctctcact cgcatcgctc
    22741 tgagcggcct ggcgctccag gcggatcttc ttgggtacgt ggcggtccag gccgcgtacg
    22801 tcgatgacgg ccttgccgcc gtcgggcagt tcgaccgtga cgcggtcgcc gactgccggg
    22861 aagcggccaa gctggtcgac gatcaggccc gcgacggtgt cgtagtcctc ttcctcgggc
    22921 agctcgatgc cggtggcctc ggcgacctcg tccaggcggc gtccggcgtc caccagccag
    22981 ccgtccccgt cagcgacggc gagttccacg actgtgtcgc tttcgtcggc gatgtccccg
    23041 accagttcct cggcgatgtc ctcgtacgtg acgatgcctg ccacgccgcc gtgctcgtcc
    23101 aggacgacgg cgaactcgtc gccccgctca cgcatctgcg ccaccgcgtc cggcagctcc
    23161 agcgtgtccg gcagcagcag cggccgccgg gcgagcgtgc ccgccgtcgt actggtcagg
    23221 ctctcggcgg gcagccgcgt cagctcgcgg acgcccagca caccgccgac gtcgtccggg
    23281 tggtcgccga ggaccgggta gttggagtgg ccgtgctcgg cgatcagtct gaccgcgtcg
    23341 gccgcgctcg cgcccttgcg gacgaagacg gcgtcggcgc gcggcaccat cacctcgtcc
    23401 agggtgcgct cggagaactc cagggcgtga tcgaggagcg ccgcggtgtc cttgggcagc
    23461 tcgccctgct cgtgggactc gccgatgagg tgacccagct cctccagggt cgccccgtgg
    23521 tgcagctcct cgaccggttc gatcccgatg cggcgcagca gcctgttcgc ggtgctgtcg
    23581 aagatccgta cgacaggtcc gacgatcttc agatacgcga gggtggagga ggccagggac
    23641 ttggcgagcc ggtcgggcac ggcgagcgcg aggttcttcg gagccagctc gcccaggacc
    23701 atctgtacga cggtggcgag gacgaaggcg aggaccacgg agatgccgct gacggcgccg
    23761 tccgggacac ccatcccgtt cagcacgggc ctgagcagcg cggacacgga cggctcggcg
    23821 atgaagccga cgaccagacc ggtgaccgtg atgccgagct gggcgcccga cagcatgaag
    23881 gacagccgct caaggacctt cagggcgcgg gcggcacgct tgtcccccgc ttcggcctca
    23941 cgggccaggg cgaggcggtc cgcggagacg taggcgaatt cctgggcgac gaaatagccc
    24001 gtaccggcgg tcaggacgaa gacggccagc aggcccagca ctgcgctcat cggcgcgtca
    24061 tgggagagct ggcatcctgg cgcctgccgc gatcaccgag agcgtcgagg gcacgagcat
    24121 cgagagcgcc caggatctgg cggggcgcgc ggagagggcg aggagggtgg ggactgtgcc
    24181 ccggagggtc cgtcggtctg ccggacaagt gctggctcct tgtgaactgg atcggtttct
    24241 gtggaacgag tctcatggcg ggtgagttcc tccgccaccg agaggcccgt gcaggtcagc
    24301 gcaggtcagc gcgggtcagc gccgggacgt ggcgcgttcg cgatccctgg cgggggtggc
    24361 ggcgtcgggt gtgaaggccc actccatctt cggctccatc gcgaagcgga acgcccgccg
    24421 caccggtggc gtacacagca gcgtgatcac cgttgcggcg atgagcgtca ccacgatctc
    24481 gccgagcggc tggtgcaccc aggcggcgtc gtaccagtcc cagaagcggg agcccttggc
    24541 caggaagccg tgtagcaggt agccgtacag tgtgccggcg ccgagcgcgg tgaaccacag
    24601 tttacggccc gggacccagg cgaagaaaca ggcgacgaga accagggagc agccgaacat
    24661 ccccagcgtc atcacaccgc ccgcccagcc gggcgctgcg agctcctggg cgctgtcgcg
    24721 gcggtagaac caggccgtgt tcatccgctc ggtcgcccag tacgcgaaga ccagcgccgc
    24781 cgcgaagacc gggaccgcca ggacccgtac ttccttgcgg cgcaccagct ggaagtgctc
    24841 cggcttcagg cggagcccga ggacgaagaa gggcaagaac tgcagcaccc gttgcaggtc
    24901 gaggtcgtcg ccgatgtccg gggacacgga cgccaggacg gcgatggcga cggccagcga
    24961 cagcggccag cgcaccatct tccacagcgg ggtggtcagc cgccagatga acagcgcggc
    25021 caggaaccag gtcaggtacc aggggtcgag caggctgatc ggatacgtcg ggtcgtcatc
    25081 cgcccaccgt ttgaagaagg tgtacgcgac ctcgaagatc acgtacggca ccgcgatccc
    25141 ggtgaccagg cgcttgaggc ggtccgggct cgcgtcgaag ctgcgcgaga agtagccgga
    25201 gatgacgatg aacgccggca tgtggaaggt gtacacggtg atgtacagcg cggccgcggc
    25261 ccggctgtcg tcgcgcagcg gctcccacgc gtgccccagc gccaccagga cgatcgcgag
    25321 gtacttggcg ttgtcgaaga acgcgtcccg ctgcttgacc ggcctgtcgg cacccgtcgc
    25381 tcggtcggca cccgccgccg actcgccctg ggctgcccag tcctgagccg ccccgccacc
    25441 ggagtccgtg tcgggggcag gccactgccg gggaagcggc ggcgcgtggc ggcgtgtcag
    25501 ccgcagcatg ttgctcacga ttgctcctgt ggggaacctc ggcgcggccg tcctcgtctt
    25561 acacgggtta cggagtcgcg tcgcagcaga acatccccag caccctagcc acacacctac
    25621 agccccgtaa aacccccctc ccggtcatca caaatgaccg gcaaagcttc caggtcaagc
    25681 ccgctggcgg cctgaatggc gacggttttc ggacgttccc gcggcagctt ctggaggagg
    25741 gcctggaccg gccccggcag ctctaagctg ctaatcgcct ggggagaaac cggtcccttt
    25801 cccctccacc ttcaccacct cacctcacct cacctggagc agacgcatgg cttcgatcga
    25861 cctggacaag gtgctcgaca aggcgtgggc ggacaagagc ctgcccgaga tactggcggc
    25921 tccggcctcg gccctgaaag gggtgtccga ccgcgatgga gagctgcttc aggaggcgtt
    25981 cggggtcaag actgtggccg atcttgccga gttgaagtac gtccgatggg cccaggcact
    26041 ggctgccctg gacacgtcag cgaagtaacc gaaccagccc agtcacaaga accacacgca
    26101 cgtaaggggt gaacgccacg atggtgttca aacggctgct cggctcgctc ggcgtcggcg
    26161 cacccacggt cgacacggtc ctcgacccgg gtgcggccct gcccggcggc acgctctcag
    26221 ggcaggtccg cctcaagggc ggcagtgccg acttcgacat cgagcacatc accttggagc
    26281 tggtcgcccg ggtcgaggtc gagcacgagg acggggaggg cgaaggcgcc gtc
//
