LOCUS       NZ_WHOM01000078        23579 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces apocyni strain TRM 66233 522, whole genome shotgun
            sequence.
ACCESSION   NZ_WHOM01000078
VERSION     NZ_WHOM01000078.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces apocyni
  ORGANISM  Streptomyces apocyni
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 662149)
  AUTHORS   Liu,W.
  TITLE     Streptomyces poacynumensis sp. nov., a endogenous actinomycete
            isolated from Poacynum hendersonii
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 662149)
  AUTHORS   Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2019) Key Laboratory of Protection and Utilization
            of Biological Resources in Tarim Basin of Xinjiang Production &
            Construction Corps, Tarim University, Xingfu Road, Alar, Xinjiang
            843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABySS v. 2.2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009739465.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 17:09:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,397
            CDSs (total)                      :: 6,319
            Genes (coding)                    :: 6,205
            CDSs (with protein)               :: 6,205
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 34 of 114
            Pseudo Genes (incomplete)         :: 100 of 114
            Pseudo Genes (internal stop)      :: 6 of 114
            Pseudo Genes (multiple problems)  :: 23 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:56:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 23579
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHOM01000078.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23579
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..23579
                     /SMILES="NC(C(O)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23579
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:3579](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..3579)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            complement(<1..3579)
                     /locus_tag="GCN81_RS28520"
     CDS             complement(<1..3579)
                     /NRPS_PKS="Domain: Condensation_Starter (7-300). E-value:
                     5.2e-113. Score: 369.2. Matches aSDomain:
                     nrpspksdomains_GCN81_RS28520_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (465-887). E-value:
                     9.8e-119. Score: 388.5. Matches aSDomain:
                     nrpspksdomains_GCN81_RS28520_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (993-1058). E-value: 9e-23. Score:
                     72.3. Matches aSDomain: nrpspksdomains_GCN81_RS28520_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="GCN81_RS28520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_156727437.1"
                     /sec_met_domain="Condensation (E-value: 3.7e-55, bitscore:
                     182.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1e-124, bitscore:
                     411.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.4e-14, bitscore:
                     48.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHSQDFQLPLTAAQSGIWFAQQIDPESTVYNTGEYLEIHGPVDG
                     SLFEAALRQVVAEAENLRARFVADETGPRQVIEAAPQWELCHVDVSDRPDPQAAAEEWM
                     RADFARPLDPTQGPLFLFALFKAAPDRWFWLHRYHHLLVDGFTVALIAQRVAAVYTALV
                     EGTEPEPSPFRPLRDLVDADAAYRESERFETDRDYWLERLAQRSAPVSLSTQHPATARA
                     LVRRTEYLEASAVERLRDIAREAGSPWPPVVLAAVAAYLQRLTGAPEVTLGLPVSTRLG
                     REARTTPGMVSNVLPLRLAPRADMTVAELLRHASAEMRGAMRHQRYRYEDLRRDLKAVG
                     EDERLVGPQVNIMMFTYDLRFGGHRGTPHNLSIGPADDMSFIVYDRGDGSGLQIDVDAN
                     PDLYTPDELAAAQRRFLHFLENLAQAAPDQPLGRVDVLTPAEREQIAAAPAQAPAPHVP
                     AATLSELFEAQAARTPDAVAVVCEDTRLTYTQLNEAANRLARLMVAQGVGPERLVALAL
                     PRSVEMAVALLAVLKAGGAYVPLDPAYPADRLAYMITDARPSLLLTTAETATGPLADVL
                     AGQGADTALLVLDAPEVRDTLDGLSGTDLTDTDRLAPLSPLAPAYVIYTSGSTGRPKGV
                     VIPHQNVVRLFGATDHWFGFGADDVWTMFHSYAFDFSVWEIWGPLLHGGRLVVVPHTVS
                     RSPEDFLRLLVDERVTVLNQTPSAFYQLMRAGQDNPGLGSDLALRSVVFGGEALDLWRL
                     EEWYARHRADAPVLVNMYGITETTVHVSHIALDRATAAAGRGSVIGEAIPDLRVHVLDQ
                     ALRPTPPGVSGEMYVSGAGLARGYLGRPGLTAERFVANPYGAPGERMYRTGDLARWQHD
                     GNLEYLGRSDHQVKIRGFRIELGEIEAALAACEGVAQSAVLVREDRPGDKRLVGYVVPA
                     AETRPEGARLRELLLATLPEHMVPAAFVTLDALPLTPNGKLDHKALPAPVNAPVNGRAA
                     DTPEEKLLAGLAADVLGLPAVGADDSFFDLGGDSIMAIQLVSRARKAGLVFTPRDVFQR
                     KTVAGLASVAMPADTAVVEDPDAGIGDIPLTPIMHWLRERPGPIDGSHQSMLVRLPAGL
                     GEDRLASALQTVLDHHDALRARLVRTGSDVWSLEVAERGTVQARECVQRVDTTGLDSDG
                     VRDVLVREAEAARSRLAPEAGAMVQAV"
     CDS_motif       complement(187..255)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0011"
                     /evalue="2.40E-05"
                     /label="C2_starter_024-063"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="1131"
                     /protein_start="1108"
                     /score="17.0"
                     /tool="antismash"
                     /translation="EDRLASALQTVLDHHDALRARLV"
     aSDomain        complement(406..600)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GCN81_RS28520_PCP.1"
                     /evalue="9.00E-23"
                     /label="GCN81_RS28520_PCP.1"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="1058"
                     /protein_start="993"
                     /score="72.3"
                     /tool="antismash"
                     /translation="EKLLAGLAADVLGLPAVGADDSFFDLGGDSIMAIQLVSRARKAGL
                     VFTPRDVFQRKTVAGLASVA"
     aSModule        complement(406..3558)
                     /complete
                     /domains="nrpspksdomains_GCN81_RS28520_Condensation_Starter
                     .1"
                     /domains="nrpspksdomains_GCN81_RS28520_AMP-binding.1"
                     /domains="nrpspksdomains_GCN81_RS28520_PCP.1"
                     /locus_tags="GCN81_RS28520"
                     /monomer_pairings="Thr -> Thr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(448..477)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0010"
                     /evalue="3.70E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="1044"
                     /protein_start="1034"
                     /score="-1.1"
                     /tool="antismash"
                     /translation="KAGLVFTPRD"
     CDS_motif       complement(889..954)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0009"
                     /evalue="8.30E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="897"
                     /protein_start="875"
                     /score="40.1"
                     /tool="antismash"
                     /translation="YLGRSDHQVKIRGFRIELGEIE"
     aSDomain        complement(919..2184)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GCN81_RS28520_AMP-binding.1"
                     /evalue="9.80E-119"
                     /label="GCN81_RS28520_AMP-binding.1"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="887"
                     /protein_start="465"
                     /score="388.5"
                     /specificity="substrate consensus: Thr"
                     /tool="antismash"
                     /translation="FEAQAARTPDAVAVVCEDTRLTYTQLNEAANRLARLMVAQGVGPE
                     RLVALALPRSVEMAVALLAVLKAGGAYVPLDPAYPADRLAYMITDARPSLLLTTAETAT
                     GPLADVLAGQGADTALLVLDAPEVRDTLDGLSGTDLTDTDRLAPLSPLAPAYVIYTSGS
                     TGRPKGVVIPHQNVVRLFGATDHWFGFGADDVWTMFHSYAFDFSVWEIWGPLLHGGRLV
                     VVPHTVSRSPEDFLRLLVDERVTVLNQTPSAFYQLMRAGQDNPGLGSDLALRSVVFGGE
                     ALDLWRLEEWYARHRADAPVLVNMYGITETTVHVSHIALDRATAAAGRGSVIGEAIPDL
                     RVHVLDQALRPTPPGVSGEMYVSGAGLARGYLGRPGLTAERFVANPYGAPGERMYRTGD
                     LARWQHDGNLEYLGRSDHQVKIR"
     CDS_motif       complement(1039..1128)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0008"
                     /evalue="1.60E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="847"
                     /protein_start="817"
                     /score="52.3"
                     /tool="antismash"
                     /translation="PPGVSGEMYVSGAGLARGYLGRPGLTAERF"
     CDS_motif       complement(1663..1722)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0007"
                     /evalue="7.00E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="639"
                     /protein_start="619"
                     /score="33.9"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVVIPH"
     CDS_motif       complement(1957..1998)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0006"
                     /evalue="2.30E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="541"
                     /protein_start="527"
                     /score="20.5"
                     /tool="antismash"
                     /translation="LAVLKAGGAYVPLD"
     CDS_motif       complement(2524..2637)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0005"
                     /evalue="5.00E-19"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="352"
                     /protein_start="314"
                     /score="60.7"
                     /tool="antismash"
                     /translation="SAEMRGAMRHQRYRYEDLRRDLKAVGEDERLVGPQVNI"
     aSDomain        complement(2680..3558)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GCN81_RS28520_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="5.20E-113"
                     /label="GCN81_RS28520_Condensation_Starter.1"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="300"
                     /protein_start="7"
                     /score="369.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHLLVDG"
                     /tool="antismash"
                     /translation="QLPLTAAQSGIWFAQQIDPESTVYNTGEYLEIHGPVDGSLFEAAL
                     RQVVAEAENLRARFVADETGPRQVIEAAPQWELCHVDVSDRPDPQAAAEEWMRADFARP
                     LDPTQGPLFLFALFKAAPDRWFWLHRYHHLLVDGFTVALIAQRVAAVYTALVEGTEPEP
                     SPFRPLRDLVDADAAYRESERFETDRDYWLERLAQRSAPVSLSTQHPATARALVRRTEY
                     LEASAVERLRDIAREAGSPWPPVVLAAVAAYLQRLTGAPEVTLGLPVSTRLGREARTTP
                     GMVSNVLPLRLA"
     CDS_motif       complement(2686..2775)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0004"
                     /evalue="3.20E-14"
                     /label="C5_starter_265-294"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="298"
                     /protein_start="268"
                     /score="45.1"
                     /tool="antismash"
                     /translation="EVTLGLPVSTRLGREARTTPGMVSNVLPLR"
     CDS_motif       complement(3103..3168)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0003"
                     /evalue="3.40E-08"
                     /label="C3_starter_134-155"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="159"
                     /protein_start="137"
                     /score="26.3"
                     /tool="antismash"
                     /translation="YHHLLVDGFTVALIAQRVAAVY"
     CDS_motif       complement(3379..3492)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0002"
                     /evalue="4.10E-16"
                     /label="C2_starter_024-063"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="67"
                     /protein_start="29"
                     /score="51.5"
                     /tool="antismash"
                     /translation="VYNTGEYLEIHGPVDGSLFEAALRQVVAEAENLRARFV"
     CDS_motif       complement(3514..3555)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28520_0001"
                     /evalue="1.70E-04"
                     /label="C1_starter_004-017"
                     /locus_tag="GCN81_RS28520"
                     /protein_end="22"
                     /protein_start="8"
                     /score="14.1"
                     /tool="antismash"
                     /translation="LPLTAAQSGIWFAQ"
     misc_feature    3578..3593
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.87"
                     /tool="antismash"
     misc_feature    complement(3579..3588)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            complement(3828..4040)
                     /locus_tag="GCN81_RS28525"
     CDS             complement(3828..4040)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009: mbtH-like protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981600.1"
                     /locus_tag="GCN81_RS28525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MbtH family protein"
                     /protein_id="WP_156727438.1"
                     /transl_table=11
                     /translation="MATNPFEDDSARYFVLVNDENQHSLWPAFAEIPDGWRAVHGQDSR
                     QACADYINENWTDMRPKSLAEAMAD"
     misc_feature    4350..4368
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.28"
                     /tool="antismash"
     gene            <5120..>5832
                     /locus_tag="GCN81_RS28530"
                     /pseudo=""
     CDS             5120..>5832
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003979132.1"
                     /locus_tag="GCN81_RS28530"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="ISKra4 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHRGARRGSAPVRRAARRSRGRTRWHAAPGGAGAVGCGVAGARRQ
                     RRGAAYTGLARPGRTAANLAGDGAVGKRRPTELVQAAAVGIAAYYAAKIPTPRTREMPL
                     VVQIDGTGVVMRPEATRRAAAKTAAAGRRGRLAPGEKLHRIIHPPGGRSELRTPRPGPT
                     AQRKWCTPRWSARPSR"
     misc_feature    complement(5859..5876)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     tRNA            complement(5915..5988)
                     /anticodon=(pos:complement(5952..5954),aa:Thr,seq:tgt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="GCN81_RS28535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Thr"
     gene            complement(5915..5988)
                     /locus_tag="GCN81_RS28535"
     misc_feature    complement(6176..6191)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.24"
                     /tool="antismash"
     gene            6245..7381
                     /locus_tag="GCN81_RS28540"
     CDS             6245..7381
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029527.1"
                     /locus_tag="GCN81_RS28540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_156727439.1"
                     /transl_table=11
                     /translation="MATVSFDKATRIYPGSEKPAVDQLEIEIEDGEFLVLVGPSGCGKS
                     TSLRMLAGLEDVNGGAIRIGDRDVTHLPPKDRDIAMVFQNYALYPHMTVADNMGFALKI
                     AGVPKAEIRQKVEDAAKILDLTEYLGRKPKALSGGQRQRVAMGRAIVREPQVFLMDEPL
                     SNLDAKLRVSTRTQIASLQRRLGITTVYVTHDQVEAMTMGDRVAVLKDGLLQQVDSPRN
                     MYDRPANLFVAGFIGSPAMNLIEVPITDGGVKFGNSVVPVSREALAVAADKGDRTVTVG
                     VRPEHFDIVEQNGEFAKSLSKDTDDAPAGMAVSVNVVEELGADGFVYGTAEVDGEHKDL
                     VVRVHGRRVPEKGSQLHVVPRAGEAHVFATSTGERLTD"
     misc_feature    complement(7523..7532)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.67"
                     /tool="antismash"
     gene            7692..8105
                     /locus_tag="GCN81_RS28545"
     CDS             7692..8105
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005315662.1"
                     /locus_tag="GCN81_RS28545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156727440.1"
                     /transl_table=11
                     /translation="MNSTARRIGRTLALVLPVVLVLSGTLAVTRVDWSGNPQSTLTASS
                     EEVSSRAKSRAPQDILREKLLDELQEKDPGVALTHLQTEVDRRPSLAAHCVSIARALGR
                     AAVQYYGPTRAQSFARPVCDTAFASGVAAQQQS"
     gene            8218..8976
                     /locus_tag="GCN81_RS28550"
     CDS             8218..8976
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130314.1"
                     /locus_tag="GCN81_RS28550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_156727441.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 9.2e-13, bitscore:
                     44.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGDLPVPNHAAATPLSHPTQAVVLAGGQGSRLRPYTDDRPKPMV
                     EIPGTGTPIIGHQLSWLAAEGVTDAVVSCGHLAEVLQDWLATADLPLRVTTVVEKEPLG
                     RGGGLKYAAAHLPHPDQPWYATNGDIWTRFSLRDMASFHAERDATATLALARPRIPWGA
                     VETDDFGHITDFIESPPTSYQINAGVYVFSPAFASLLPDRGDHERTTFPRLARDRRLAG
                     YPLPQGAYWRAIDTAKDLTEAAKELAAQNR"
     gene            complement(9081..10838)
                     /locus_tag="GCN81_RS28555"
     CDS             complement(9081..10838)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659569.1"
                     /locus_tag="GCN81_RS28555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DoxX family protein"
                     /protein_id="WP_231627046.1"
                     /transl_table=11
                     /translation="MSVDTRTPRTPTGGPSGFDDGPALSMVKVPCDPAQVIVNHASFRV
                     QLPAAQQPRSPRITRPLAGAVPAHTARIPVAAAGGAAGAVGGVVAGAAAAGRRRAPVVW
                     SGKSEPGDLAATGLLQAVRSSGVRHGASYDEPFDADGFDADGYDADETQLIPRFDDDAT
                     QTIETPQVFGPRGPSGDETRALPVVPGAGAAAGFPEGLFRPEPDHGYDEPDAYADDDEP
                     VVARRRGADPVRHAYYPGRRMNLGVVLLPLRVFLGFISIYAGMGKLCDPVYFDGGERGS
                     MVKWLSSLHPWTLAEPMRDFALSHPVGAGLTIAFLQVIVGVLTVLGLWQRLAASVGALL
                     SAALLVTVSWKSVPVYDTPDIIYLAAWSPLIIAGAPVYSADGRLASEAWRRLGPRAGIW
                     ELRRRVLRRGALIATLVVGLTLLLGALLGSAVRDSGRVIVPGPGEPPRNVLPGSPLPSE
                     PGARTSEPGSLRPSASQGPTQGNTTSPSTPSQVTPEAARESSTAGAAEQQPTESQPSQT
                     QGTTGEEAPQPPPQQAPPPPPSTSAGPTSSGGTDDSTDSGTSTGGPDDGASGGTSSGGQ
                     PGLVGGLLG"
     gene            complement(10961..11905)
                     /gene="rlmB"
                     /locus_tag="GCN81_RS28560"
     CDS             complement(10961..11905)
                     /GO_function="GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rlmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018847135.1"
                     /locus_tag="GCN81_RS28560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="23S rRNA (guanosine(2251)-2'-O)-methyltransferase
                     RlmB"
                     /protein_id="WP_156727442.1"
                     /transl_table=11
                     /translation="MAGSSSSRRTSNKKGAQVGSGGKRRRGLEGKGPTPPAEMRKKHKK
                     NRVATAQKKAAARRPVARRGGKGASELVVGRNSVVEALREGVPANTLYVQQFIDNDERV
                     REALQLAAERGGINLMEAPRPELDRMTNGLNHQGLVMQVPPYEYAFPEDLAAAAFDEGE
                     DPLIVALDGVTDPRNLGAVVRSVSAFGGHGVVVPERRAAGMTAGAWKTSAGAAARTPVA
                     RATNLTRALEAYKKAGVAVVGLAADGEHEVGELDALRGPVVIVVGSEGKGLSRLVGETC
                     DYLVRIPMPGGTESLNAGVAAGVVLYEAARHRG"
     gene            complement(12046..13458)
                     /gene="cysS"
                     /locus_tag="GCN81_RS28565"
     CDS             complement(12046..13458)
                     /EC_number="6.1.1.16"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004817 - cysteine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006423 - cysteinyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cysS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036036.1"
                     /locus_tag="GCN81_RS28565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cysteine--tRNA ligase"
                     /protein_id="WP_156727443.1"
                     /transl_table=11
                     /translation="MTIRLYDTSARQIRDFSPLVPGCVSIYLCGATVQAAPHIGHIRSG
                     LNFDILRRWFTYRGYDVTFVRNVTDIDDKIIAKAADQGRPWWSIGYENERAFNEGYDAL
                     GCLPPTYEPRATGHITEMVEMMRGLIERGHAYAADGNVYFDVRSFDGYLQLSNQELDNL
                     LQPSGEGETGKRDPRDFAMWKAAKPGEPSWETPWGRGRPGWHLECSAMAHKYLGAAFDI
                     HGGGLDLVFPHHENEIAQAKAYGDDFAGYWMHNAWVTMAGEKMAKSLGNSVLVSEMVQR
                     WRPIVLRYYLGTPHYRSMIEYSEEALREAESAFARIEGFVQRVVEKAGAVEPAAEVPAA
                     FAEAMDDDLGVPQALAVLHTTVRHGNSALAADDKDAAVQHLAEVRAMLGVLGLDPLDPH
                     WAGEGGSAQAGAAQTLHDAVDTLVHLVLRQREAARERKDWATADAIRDQLNRSGLVIED
                     GPDGPRWSLGAR"
     gene            complement(13560..14081)
                     /gene="ispF"
                     /locus_tag="GCN81_RS28570"
     CDS             complement(13560..14081)
                     /EC_number="4.6.1.12"
                     /GO_function="GO:0008685 - 2-C-methyl-D-erythritol
                     2,4-cyclodiphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018488988.1"
                     /locus_tag="GCN81_RS28570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-C-methyl-D-erythritol 2,4-cyclodiphosphate
                     synthase"
                     /protein_id="WP_156727444.1"
                     /transl_table=11
                     /translation="MASETPAASETQAPPPRLPLVGVGTDVHAFEEGRELWCAGLLWEG
                     ERYGLAGHSDGDVAAHAACDALFSAAGIGDLGAHFGTGRPEWAGASGVALLTEAARIVR
                     AEGFEIGNVAIQVIGVRPKVGKRRDEAQKTLSAAVGAPVSVSGTTTDGLGLTGRAEGLA
                     AIATALVVRG"
     gene            complement(14071..14865)
                     /gene="ispD"
                     /locus_tag="GCN81_RS28575"
     CDS             complement(14071..14865)
                     /EC_number="2.7.7.60"
                     /GO_function="GO:0050518 - 2-C-methyl-D-erythritol
                     4-phosphate cytidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659565.1"
                     /locus_tag="GCN81_RS28575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="WP_156727445.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3e-12, bitscore:
                     42.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDESHASERPTAGPAAVPTPGRATAAVIPAAGRGVRLGPGAPKA
                     LRALSGLPMLIHAVRAMADSRGVSLVVVVAPRDGATEVKNLLDAHALPETTDYVVVPGG
                     DTRQESVRAGLDVLPPGITEVLVHDAARPLVPVDTVDAVIEAVRGGAPAVVPALPVADT
                     VKQVEPATVPGAPEPVVATPERARLRAVQTPQGFDRQTLVRAHEQVALNGEGATDDAGM
                     VEQLGVQVVVVPGHEEAFKVTRPLDLTLAEAVLARRRANDGF"
     gene            complement(15209..15691)
                     /locus_tag="GCN81_RS28580"
     CDS             complement(15209..15691)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136563.1"
                     /locus_tag="GCN81_RS28580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CarD family transcriptional regulator"
                     /protein_id="WP_003953493.1"
                     /transl_table=11
                     /translation="MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLT
                     VRVPADNAEFVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKV
                     AEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS"
     misc_feature    15745..15759
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    16029..16044
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.2"
                     /tool="antismash"
     gene            16289..17014
                     /locus_tag="GCN81_RS28590"
     CDS             16289..17014
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974744.1"
                     /locus_tag="GCN81_RS28590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF461 domain-containing protein"
                     /protein_id="WP_156727446.1"
                     /transl_table=11
                     /translation="MSRSLRRGAIAATALAFSLAALTGCGAGNNAQTLGVQPDHAATSV
                     GDIKIQNSTLITQADPETEGPAVVAVTLFNEGSKDQNLEAIKVEGIDGEADLKPAEGSG
                     PITVPAHGTVVIGGKGNASAVLADGNGTVLEGNSQPITFTFSRTGDITLRSAVVPATGQ
                     YADWGPEAPKAPASPKPTDTATAVPADEDEDEATDGTPDEATTEATPGADATGEATETP
                     GAGATDEAAQGPEGDDAAH"
     gene            complement(17148..17828)
                     /locus_tag="GCN81_RS28595"
     CDS             complement(17148..17828)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008410337.1"
                     /locus_tag="GCN81_RS28595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_156727447.1"
                     /transl_table=11
                     /translation="MTRVLVVEDEESFSDALSYMLRKEGFEVAIAATGPDGLDEFERNG
                     ADLVLLDLMLPGLPGTEVCRQLRGISNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPFS
                     SRELVARIRAVLRRRGEPEEVSPAALEAGPVRMDVDRHVVTVSGGKVDLPLKEFDLLEM
                     LLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGY
                     KFEP"
     gene            complement(17825..19132)
                     /locus_tag="GCN81_RS28600"
     CDS             complement(17825..19132)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072375.1"
                     /locus_tag="GCN81_RS28600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_231627047.1"
                     /transl_table=11
                     /translation="MDVNAAVAAAAAIAGACTGAIAMLAFRWSERDQKRPTRTSLHTDA
                     VLPPGVDTVLSVLRSSAVVLDEGDAVVKASSAAYALGLVRGGKLAVEPMLKMARDTRRD
                     GEIRQVELDLPRRGTGRGEALAVSARVAPLGSRLILLLVEDLTEARRIEAVRRDFVANV
                     SHELKTPVGALSLLSEAVMDASDDPEAVERFAGRMQIEATRLTNLVQELIDLSRVQNDD
                     PLEDAEAVRVDELVAEAMDRCRHQAGTKEITMAAGGVGDLRIWGNRGQLAAALGNLVEN
                     AVNYSPARTRVGIAARRVNAPGGDLIEIAVTDQGIGISEKDRERIFERFYRVDPARSRA
                     TGGTGLGLAIVKHVAASHGGEVTVWSSEGQGSTFTLRLPEAGSVRDRRKPLIAGGLDDE
                     GRPSDGDTADHDTTHDTTNEQARATRGPLPAPEVLP"
     misc_feature    complement(19119..19130)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            19437..20135
                     /gene="phoU"
                     /locus_tag="GCN81_RS28605"
     CDS             19437..20135
                     /GO_process="GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0030643 - intracellular phosphate ion
                     homeostasis [Evidence IEA]"
                     /GO_process="GO:0045936 - negative regulation of phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="phoU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018553681.1"
                     /locus_tag="GCN81_RS28605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="WP_156727448.1"
                     /transl_table=11
                     /translation="MRDAYHEELDSIGEGLVEMARLVGSAIGRATTAMLDADLKLAESV
                     IAGDQKVDDLQHDLEARAIALLARQQPVATDLRIVVTSLRMSADLERSGDLAQHVAKLA
                     RLRFPESAVPNDLHATILEMGQLAQRLMAKSAEVIITKDIDLALQLEQDDDEMDLLHRT
                     LFRHLMDDRWKHGIETAVDVTLLGRYYERFADHAVSVAKRVVYLVTGEHADELQAATAA
                     ATATAPTEGA"
     misc_feature    20196..20209
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.85"
                     /tool="antismash"
     gene            20253..20405
                     /locus_tag="GCN81_RS32065"
     CDS             20253..20405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143238.1"
                     /locus_tag="GCN81_RS32065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_197287820.1"
                     /transl_table=11
                     /translation="MADTPTPDAHQDNDQVQVIHLPLLGACGCGAGCGCGCQSGAPCQC
                     GGCCG"
     gene            complement(20499..21260)
                     /locus_tag="GCN81_RS28610"
     CDS             complement(20499..21260)
                     /EC_number="5.4.2.11"
                     /GO_function="GO:0004619 - phosphoglycerate mutase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948988.1"
                     /locus_tag="GCN81_RS28610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoglyceromutase"
                     /protein_id="WP_156727449.1"
                     /transl_table=11
                     /translation="MADAPYKLILLRHGESEWNAKNLFTGWVDVNLNEKGEKEAVRGGE
                     LLKDVGLLPDVVHTSLQKRAIRTANLALEAADRHWIPVHRSWRLNERHYGALQGKDKAQ
                     TLAEFGEEQFMLWRRSYDTPPPPLADGAEFSQSDDARYASIPPEMRPRTECLKDVVTRM
                     LPYWYDGIVPDLLTGSTVLVAAHGNSLRALVKHLDGISDADIAGLNIPTGIPLSYELNA
                     EFKPLNPGGTYLDPDAAKAAIEAVKNQGKKK"
     gene            21394..22794
                     /locus_tag="GCN81_RS28615"
     CDS             21394..22794
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009189330.1"
                     /locus_tag="GCN81_RS28615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_156727450.1"
                     /transl_table=11
                     /translation="MSFASLRRSARESVSGLPGGFWWLWLSTLVNRTGAFVLTFMSLYL
                     TQELGYSAWYAGLVIALHGLGGIAGSPLGGMLSDRWGRRPTMITAHLGGAVCAAALAVV
                     TSAWGIAVVVLLMGVAMQAVRPAIGATIADLVPEADRRRAYSLNYWALNLGFAIAAMGG
                     GAAIFLGYRTLFVADAVATVLCALIVFLRLGETRPAPASTSGDASARAAGEAKAKVTTF
                     SVLRDDKAFRTLVLLNLMVCLVFTAPWVGLPLTMAAKGLEPSAYGMVIAVNGVVIVAFQ
                     LLVNKITERRSPAALLTVSSLLFALGTGLTVLAGTPLLFAATVVVWTIGEMVHIPTNSA
                     ATARLAPEHARGRYQGVMGMSWAVAGFVAPILAGWVVDGPGPGALWLGCGVLGSAAAVG
                     YAVLLRRALGTEEGAAEGAAEAEGAAESDDVPGGVRGEAVADAASEAGTASEPASEAGT
                     ELSSRVAG"
     gene            complement(22772..23263)
                     /locus_tag="GCN81_RS28620"
     CDS             complement(22772..23263)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985434.1"
                     /locus_tag="GCN81_RS28620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YbjN domain-containing protein"
                     /protein_id="WP_156727451.1"
                     /transl_table=11
                     /translation="MADAAAIIEQSLADADVEWESPEPGSYVVTLPGTHKLSTTVSLIV
                     GKHALSLNAFVIRHPDENAEGVHRWLLERNLKLYGVGYAVDQLGDVYLTGKLPLSAVTA
                     EELDRLLGSVLEAADGSFNTLLELGFASAIRKEYEWRVSRGEPTRNLDAFAHLTQPRAN
                     "
ORIGIN
        1 cacggcctgc accatcgccc cggcctccgg ggcgagcctg ctccgggcgg cctcggcctc
       61 ccgcaccagc acatcccgca ccccgtcact gtccaggccg gtggtgtcca cccgctggac
      121 gcactcacgc gcctgcacag tgccgcgctc ggcgacctcc aatgaccaca cgtcactgcc
      181 cgtacgtacg agtcgggcac gcagcgcatc gtggtggtcc agaacggtct ggagcgccga
      241 cgcgagccgg tcctcgccca gccccgcagg caaccgcacc agcatcgact ggtgcgagcc
      301 gtcgatcggc ccggggcgtt cgcggagcca gtgcatgatc ggtgtgagcg ggatgtcgcc
      361 gatgcccgcg tccgggtctt ccaccaccgc ggtgtcggcg ggcatcgcca cgctggccag
      421 gcccgcgaca gtcttgcgct ggaacacatc acgcggagtg aacaccagac cggccttgcg
      481 ggcccggctg accagctgga tggccatgat gctgtcgccg cccaggtcga agaaactgtc
      541 gtcggcgccg acggcgggca gtccgaggac atcggcggcc agcccggcga gcagcttctc
      601 ttccggggtg tccgctgccc gcccgttcac gggcgcgttc acgggcgcgg gcagcgcctt
      661 gtggtcgagc tttccgttgg gcgtgagcgg cagcgcgtcc aacgtcacga aagcggccgg
      721 aaccatgtgc tccggcaggg tcgccagcag cagctcacgc agccgcgcgc cctccggccg
      781 ggtctcggcg gcgggcacca cgtagccgac caggcgcttg tcgcccggcc ggtcctcgcg
      841 gacgagcacc gcggactgcg cgacaccctc gcacgcggcg agtgcggcct cgatctcgcc
      901 cagctcgatg cggaagcccc tgatcttgac ctggtggtcc gaacggccca ggtactcgag
      961 gttgccgtcg tgctgccagc gggcgaggtc gccggtgcgg tacatccgct cgcccggagc
     1021 cccgtacggg ttggcgacga agcgttcggc ggtcaggccc ggacggccca ggtagccgcg
     1081 tgccagaccc gcgcccgaca cgtacatctc cccggacact ccgggcgggg tggggcgtag
     1141 cgcctggtcc aggacgtgta cgcgcagatc ggggatggcc tcgccgatca cgctgccgcg
     1201 gcccgcggcg gcggtggccc ggtccagggc gatgtggctg acgtggaccg tggtctcggt
     1261 gatgccgtac atgttcacga ggaccggtgc gtcggcccgg tgccgggcgt accactcctc
     1321 caggcgccac aggtcaagtg cctcaccgcc gaagaccacc gagcgcagcg ccaggtccga
     1381 tcccagcccc gggttgtcct ggccggcgcg catcagctgg tagaaggcgg acggggtctg
     1441 gttgagcacg gtcacccgct cgtccacgag cagccgcagg aagtcctccg gggagcggct
     1501 gacggtgtgc gggacgacga ccaggcgtcc gccgtgcagc agcggacccc agatctccca
     1561 gacggagaag tcgaaggcgt aggagtggaa catcgtccac acgtcgtccg cgccgaagcc
     1621 gaaccagtgg tcggtcgcgc cgaacagacg caccacgttc tggtggggga tcaccacgcc
     1681 cttggggcgc ccggtcgagc ccgaggtgta gatgacgtaa gcgggggcca ggggcgacag
     1741 aggcgcgagg cggtcggtgt ccgtcaggtc ggtgccggac aggccgtcca gcgtgtccct
     1801 gacctccggc gcgtctagga ccagcagcgc ggtgtcagcg ccctgccctg cgagcacgtc
     1861 ggccaagggg ccggtggccg tctcggcggt ggtcagcagc agggacggcc gggcatccgt
     1921 gatcatgtag gcgaggcggt cggccgggta cgccgggtcc agcggcacgt acgccccgcc
     1981 cgccttgagc acggcgagca gcgcgacggc catctccacc gagcggggca gggccagcgc
     2041 gaccagccgc tcggggccga cgccctgcgc gaccatcagc cgggccagcc ggttggccgc
     2101 ttcgttcagc tgcgtgtacg tcagccgggt gtcctcgcag acgacggcga ccgcgtccgg
     2161 cgtacgggcc gcctgcgcct cgaacagctc gctcagggtg gcggccggca cgtgcggcgc
     2221 cggggcctgg gccggtgccg cggcgatctg ctcgcgctcg gccggggtga gcacgtccac
     2281 gcggccgagc ggctggtcgg gcgcggcctg cgccaggttc tccaggaagt gcaggaaacg
     2341 ccgctgggcg gcggccagtt cgtcgggggt gtagaggtcc gggttggcgt ccacgtcgat
     2401 ctgcaggccg ctgccgtcgc ctcggtcgta gacgatgaag gacatgtcgt cggccgggcc
     2461 gatggacagg ttgtgcggtg tgccgcggtg gccgccgaag cgcaggtcgt aggtgaacat
     2521 catgatgttc acctgcggtc cgaccagtcg ctcgtcctcg ccgaccgcct tcaggtcgcg
     2581 ccgcaggtcc tcgtaccggt accgctggtg gcgcatggcg ccgcgcatct ctgcggacgc
     2641 gtgtcgcagc agctcggcga cggtcatgtc ggcacgcggg gccagccgga gcggcagcac
     2701 gttggacacc atgccggggg tggtgcgcgc ctcgcggccc agccgggtgg acaccggcag
     2761 gccgagggtg acctccggcg cgccggtgag ccgctggagg tacgcggcga cggccgcgag
     2821 cacgaccggc ggccaggggg agcccgcctc gcgcgcgatg tcccgcagcc gctcgaccgc
     2881 cgacgcctcc aggtactcgg tacgccgcac cagggcgcgg gccgttgccg ggtgctgtgt
     2941 ggacaggctc accggggcgg aacgctgggc aaggcgctcc agccagtagt cgcggtcggt
     3001 ctcgaaccgc tccgactccc ggtacgcggc atcggcatcg accaggtcgc gcagcggccg
     3061 gaacgggctc ggctccggct cggtgccctc gaccagtgcg gtgtagacgg cggcgacgcg
     3121 ctgggcgatc agcgcgaccg tgaagccgtc gaccagcagg tggtggtagc ggtgcagcca
     3181 gaaccagcgg tcgggagcgg ccttgaagag cgcgaacagg aacagcgggc cctgcgtcgg
     3241 gtcgagcggg cgggcgaagt cggcccgcat ccactcctcg gcggctgcct gcggatcggg
     3301 gcgatcactc acatcgacgt ggcacagctc ccactgcggc gcagcctcga tgacctggcg
     3361 cggccccgtc tcgtccgcca cgaagcgcgc ccgcaggttc tcggcctccg cgacgacctg
     3421 ccggagtgcg gcttcgaaca gggagccgtc cacggggccg tggatctcca ggtactcccc
     3481 ggtgttgtag acggtgctct ccgggtcgat ctgctgagcg aaccaaattc ccgactgagc
     3541 cgcggtcaag ggaagctgga agtcctggct atgagacatc aagaatcact ctcgattgcg
     3601 gtcgctatat ctggttcatg acgaagctct tcaggcgcgt gcatgccttt ggccggttgc
     3661 ccggctcgat tggcccggag gctcggaggc tcggaggccc ggagacaaag gaatccggta
     3721 gccgggacca tgcatggggc ggcatgccac ctgcggggag cggggcgctt cgggcctcgg
     3781 cccggcgaag aagaaagagt gagggcggcg cctggtccgc tagtccgcta gtccgccatc
     3841 gcctcggcga ggctcttcgg acgcatgtcc gtccagttct cattgatgta atcggcacag
     3901 gcctgcctgc tgtcctggcc gtgcacggcg cgccaaccgt cagggatttc agcgaacgcg
     3961 ggccacagcg agtgctggtt ctcgtcgttg accaggacga aatatctcgc gctgtcatcc
     4021 tcgaagggat tggtcgccac tttcggcctt cctttcacta cctgatatcc acataccggg
     4081 ccccgcagag catcccgaaa accgtcggta gctggttgaa tcggagcgtg cggcggtgcg
     4141 accgtgatga ttgataagag agatcactga cagaagtcag ccgtccggct gctgaacgga
     4201 taattccgct ccgcccaggc ccccctgaag cgatgctttc cgtcaacgac ctgtcggcct
     4261 catcctggta ggtaccctag ggagcgccaa ccgccgcgga cagatcgaag gcaacaagtt
     4321 gccatccggc gataggtgcc atgggaaagt gctggatacg actgcagcaa atctccccat
     4381 cgatcgtgga cgcctgtaga accgtatgtt ccggaattag gcagcgctct tcccgcccct
     4441 cccccttcct ccctcgaaga gtgcgtcgag agcgcccggt gccgcgtgaa gacgggcccg
     4501 atcgagtacc ccacggcgag ggccgcgccc agccgacccc tgcctcccgg ccgacgagcc
     4561 gcaccgggcg caccgggcgc accgggcgca ccgggcgcac cggcatccag ccgcggccgc
     4621 ccgttgacgg tcaactccac tgagaaaccg gcccggtcat acgcgctgcg actacggagc
     4681 accagcgaga cccgcaagag caatcccatt tccatcacga ggagttgccc gacgaacggg
     4741 cggatcgctc aggaaacgag aggacggcac cgaactgccg accctcgccg cagccggata
     4801 ccgcaatccg tccaccgccc cccaggcacg gtcctcaacc gccgtcgagc cttcggcgcg
     4861 acgctacaaa cgatccgccc cgcgcacctc acccatgtca ccatcatgac aacaccgacc
     4921 gcccccctgc atgctcctgc cagaccaaac agaggcaata ctgccccccg ccccggcacg
     4981 agcgaccgcc caccccgtcc gaccggagag ccggccgaga ccacctgccg gacgtcaatg
     5041 gcgtgctgtt cgacgcgtcc gggaccctgc tgcggattga atcggcgcag agctggcttc
     5101 acggtgcgct cgatgaccgc ggcatcgagg cgcccgacga ggaagtgcgc ctgtacggcg
     5161 agcggctcga cgcagcaggg gccgtacccg gtggcacgcc gccccgggcg gtgccggagc
     5221 ggttggctgc ggtgtggcag gagcgcgacg gcagcgaaga ggcgccgcgt acaccggtct
     5281 ggcacggccc ggaaggacag cggcgaacct ggcgggagac ggtgcggtgg gcaaacgccg
     5341 ccccaccgag ctggtccagg ccgcggccgt cggtatcgct gcctactatg cggcgaagat
     5401 ccccaccccg cgcacccgcg agatgccgct ggtcgtccag atcgacggca cgggagtggt
     5461 gatgcggccc gaagccaccc gccgggccgc ggccaagacc gcagcggctg gacggcgcgg
     5521 acgactggcc cccggggaga aactccaccg catcatccac ccgcccggcg gccgcagcga
     5581 gctccgcacg ccacggccgg gcccgacagc acagcggaaa tggtgcacgc ctcgctggtc
     5641 cgcccgcccc agcaggtgat cgccgacgcc ttcgcccagg ccgaagcccg cgacccgggc
     5701 cacctgcgcg actggaccgt gctcgtcgac ggagctaccc gacttcgtgc acgtcgccga
     5761 gtactgctgg acggccgcgc ggccgccgag atggccgccc aggcagcagc cgaacgcctc
     5821 cccgccgccc gagcggctcg ctcccggcgc acccgccgta tccgctgaac gcaaaaggcc
     5881 cagctcagac gcggtctgag ctgggccagg gctgagcccc ctgtcggatt cgaaccgacg
     5941 acctacgcat tacaagtgcg ttgctctggc catctgagct aaggaggcgc cgcgcaccgg
     6001 cgaaggccgt gcgcagaggc tgctccactg tacacagagc gctattccca gggccacggg
     6061 gtaatccacg aggtagcccg cagcgtgatc cacggggtga ggggccgggc actggtgtgc
     6121 ggcttgctac tgacattcgg cgggcggcca ggtaacgtca cggcgagtcc actggggtgg
     6181 actacaccac tttcctttac tcggatcgtc cggcacgttc ctgccggtga agggggccct
     6241 acccatggcc actgtttcgt tcgacaaggc gacccggatc tacccgggtt ccgagaagcc
     6301 cgccgtcgac cagctggaga tcgagatcga ggacggcgag ttcctcgtcc tcgtcggacc
     6361 ctccggctgt ggaaagtcca cctccctgcg gatgctcgcg gggctcgagg acgtcaacgg
     6421 cggagcgatc cggatcggcg accgcgacgt cacgcacctg ccgccgaagg accgggacat
     6481 cgccatggtg ttccagaact acgcgctcta cccgcacatg accgtcgccg acaacatggg
     6541 cttcgcgctc aagatcgcgg gcgtgccgaa ggcggagatc cggcagaagg tcgaggacgc
     6601 cgcgaagatc ctggacctga ccgagtacct gggccgcaag cccaaggcgc tctccggtgg
     6661 tcagcgccag cgcgtcgcca tgggccgcgc gatcgtccgt gagccgcagg tcttcctcat
     6721 ggacgagccg ctgtcgaacc tcgacgccaa gctccgcgtc tcgacccgta cgcagatcgc
     6781 gtcgctgcag cgccgcctcg gcatcaccac ggtgtacgtc acccacgacc aggtcgaggc
     6841 catgaccatg ggcgaccgcg tcgcggtgct caaggacggg ctgctccagc aggtcgactc
     6901 gccgcgcaac atgtacgacc gcccggccaa cctcttcgtc gccggattca tcggctcccc
     6961 cgcgatgaac ctgatcgagg tgccgatcac cgacggcggc gtgaagttcg gcaactctgt
     7021 cgtcccggtc agccgcgagg cactggccgt cgccgccgac aagggcgacc gtacggtgac
     7081 ggtcggcgtc cgcccggagc acttcgacat cgtcgagcag aacggcgagt tcgcgaagtc
     7141 gctgagcaag gacaccgacg acgcaccggc cggaatggcc gtctcggtga acgtcgtcga
     7201 ggagctcggc gccgacggct tcgtgtacgg caccgccgag gtcgacggcg agcacaagga
     7261 cctcgtggtc cgcgtccacg gccgccgggt gcccgagaag ggctcccagc tgcacgtcgt
     7321 gccgcgtgcg ggcgaggccc atgtcttcgc gacgtcgacg ggtgagcgcc tcaccgactg
     7381 acggtccctg acacaggcca aacggccccc gcacccttgg tgcgggggcc gtttgcgctg
     7441 ccgttgccga gcgcgcggag cccgcgagtc gacaaatacc ccggcacacc ggccatttcg
     7501 gtttcgtacg tcaacccacg actcgaaaaa cgccatcgaa ccgtcccccg accgagtgac
     7561 taaatgtcgc caaatcatca ccgaccgcta cgctcactcg cgtactcctt ccccggctcc
     7621 cactcccggc ccgacaacgc cgtcgggcgg cggccggggc cacccggaat cgacaccgcg
     7681 aggaacaccc cttgaactcc accgcccgcc gtatcggccg caccctcgct ctcgtactcc
     7741 ccgttgtcct ggtgctgtcc ggaacgctcg ccgtgacccg agtcgactgg tcgggcaacc
     7801 cgcagtcgac actcaccgcc tcctccgagg aggtctcctc gcgcgccaag tcccgtgccc
     7861 cacaggacat tctgcgcgag aagctcctcg acgagctgca ggagaaggac cccggcgtcg
     7921 cgctcaccca cctccagacg gaggtcgacc gccgaccgtc gctcgccgcg cactgtgtct
     7981 ccatcgcccg cgcgctgggc cgcgccgccg tgcagtacta cggtcccacc cgtgcccagt
     8041 ccttcgcccg cccggtgtgc gacaccgcct tcgcctccgg ggtggcggct cagcagcagt
     8101 cctgagcggc gccgcagggg cgttgtgggg cccgtacgcg gcccctacgg ggcatctgcg
     8161 cggcttcctg cggggtccgc gctcggaggc gccgtgcgcg ccgcataagg tgcggtcatg
     8221 accggtgacc tccctgtacc caaccacgcg gcagccaccc cgctgtccca cccgacgcag
     8281 gccgtcgtcc tggccggggg gcagggctcg cggctgcgcc cgtacaccga cgaccggccc
     8341 aagccgatgg tcgagatccc cggcacgggg accccgatca tcggccatca gctgtcctgg
     8401 ctcgcggccg agggcgtgac cgacgcggtc gtctcctgtg ggcatctggc cgaggtgctc
     8461 caggactggc tcgcgacggc cgacctgccg ctgcgggtca ccaccgtcgt cgagaaggag
     8521 ccgctgggcc gcggcggcgg cctcaagtac gccgccgccc acctgccgca cccggaccag
     8581 ccctggtacg ccaccaacgg cgacatctgg acccgtttct cgctgcgcga catggcctcc
     8641 ttccacgccg agcgggacgc cacggcgacc ctcgcgctgg cccgcccgcg catcccgtgg
     8701 ggcgccgtcg agacggacga cttcggccac atcacggact tcatcgagtc cccgccgacc
     8761 tcgtaccaga tcaacgcggg cgtctacgtg ttctctcccg ccttcgcctc gctgctgccc
     8821 gaccgcggtg accacgagcg gaccaccttc ccgcgcctcg ccagggaccg ccgtctggcc
     8881 gggtacccgc tgccgcaggg cgcgtactgg cgggcgatcg acacggcgaa ggacctgacg
     8941 gaggccgcca aggaactggc cgcgcagaac cgttgagcca cagctgacac cagcgaaaag
     9001 cgaagaaaga gcaagaagaa agagcaaaag ggggcccggc acacgtcgcg tgtgccgggc
     9061 ccttcgcgct acggaacgcc tcagccgagc aggccgccca ccagccccgg ctggccgccc
     9121 gagctcgtgc caccggaggc gccgtcgtcc ggaccgcccg tgctggtccc gctgtcggtg
     9181 ctgtcgtccg tgcccccgct ggaggtgggc cccgcgctgg tcgacggagg cggcggtggc
     9241 gcctgctgcg gtggcggctg cggcgcctcc tcgcccgtcg tgccctgggt ctggctgggc
     9301 tggctctcgg tgggctgctg ctcggccgca cccgccgtac tggactccct ggccgcttcc
     9361 ggggtcactt gggacggggt cgaggggctg gtggtgttgc cctgcgtggg cccttgggag
     9421 gcggacgggc gcaggctgcc aggctcgctg gtccgcgcgc cgggctcgct gggcagcgga
     9481 gagcccggca ggacgttacg cggcggctcg cccggtcccg gcacgatcac ccgccccgag
     9541 tcacgtacgg cactgccgag cagcgccccg agcagcagcg tcagaccgac gacgagcgtg
     9601 gcgatcaggg ccccgcgacg gagcacccgg cggcgcagct cccagatccc cgcccgcggt
     9661 cccagcctgc gccaggcctc gctggccagc cgtccgtcgg ccgagtagac cggcgccccg
     9721 gcgatgatca gcgggctcca ggcggcgagg tagatgatgt ccggcgtgtc gtagaccggt
     9781 acggacttcc agctgacggt gacgagcagc gcggcggaca gcagggcgcc caccgaggcg
     9841 gcgagccgct gccagagacc gagcaccgtg agcacgccga cgatgacctg gaggaaggcg
     9901 atggtcagcc cggcgcccac cgggtgggac agggcgaagt cccgcatcgg ctcggcgagc
     9961 gtccaagggt gcagcgagct cagccacttg accatggagc cgcgctcgcc gccgtcgaag
    10021 tagacggggt cgcagagctt gcccatgccc gcgtagatgg agatgaatcc gaggaagacg
    10081 cgcagcggca gcagcaccac gcccaggttc atccgccgcc cggggtagta cgcgtgccgt
    10141 accgggtccg cgccgcgcct gcgggccacc acgggctcgt cgtcgtccgc gtacgcgtcg
    10201 ggctcgtcgt acccgtggtc gggttccggc ctgaagagcc cctcggggaa cccggcggcc
    10261 gcgcctgcgc cgggcaccac gggcagggcc cgggtctcgt cgccgctggg gccgcgcggg
    10321 ccgaagacct gcggggtctc gatggtctgc gtggcgtcgt cgtcgaagcg cgggatcagc
    10381 tgggtctcgt ccgcgtcgta accgtccgcg tcgaacccgt ccgcgtcgaa gggctcgtca
    10441 tacgaggcgc cgtgccgtac cccggagctg cgtacggcct gcaggagacc ggtcgccgcg
    10501 aggtcgcccg gttcggactt cccgctccag acgaccgggg cgcgacgccg tccggccgcg
    10561 gctgcgcccg ccacgactcc cccgacggcc cctgccgcgc cccccgccgc ggccacggga
    10621 atccgggccg tgtgcgccgg gacggcgccc gccagaggtc gggtgatacg cggggaccgg
    10681 ggctgctgcg cggcggggag ctgcacgcgg aagctggcgt gattgacgat gacctgcgcc
    10741 gggtcgcacg gaaccttcac catgctcagc gcggggccgt cgtcgaatcc cgagggtccc
    10801 cccgtgggtg tgcggggcgt tctggtgtcc acactcatct aaccgagtga tctgtgttta
    10861 ggacactgcc ttgacccgct ggaatctgtc cgggccgcgt caaggccacc ggggccgtat
    10921 gggcgaaccc cgatgccccc gctcagccgc ggtgctcggg tcagccgcgg tgccgggccg
    10981 cctcgtacag cacgacgccc gccgccacac cagcgttgag cgactcggtg ccgcccggca
    11041 tcggaatgcg caccaagtag tcgcaggtct caccgaccag ccgggacaga cccttgccct
    11101 cactgccgac cacgatcacg accggcccgc gcagcgcgtc cagttcaccg acctcgtgct
    11161 cgccgtccgc ggcgagcccg accacggcga cgcccgcctt cttgtacgcc tcaagggcac
    11221 gggtcaggtt ggtcgcccgg gccaccggcg tacgcgcggc ggccccggcc gaggtcttcc
    11281 aggcgcccgc cgtcattccg gcggcacgcc gctccggcac gacgacaccg tggccgccga
    11341 aggcggacac cgaacgcacc acggcgccca ggttccgcgg gtcggtcacg ccgtccaggg
    11401 cgacgatcag cgggtcctcg ccctcgtcga aggcggcggc cgcgaggtcc tcggggaacg
    11461 cgtactcgta cggcgggacc tgcatgacca ggccctggtg gttgagcccg ttggtcatcc
    11521 ggtcgagctc ggggcgcggc gcctccatga ggttgatgcc gccgcgctcg gccgcgagct
    11581 gcagcgcctc gcgcacccgc tcgtcgttgt cgatgaactg ctgcacgtac agcgtgttcg
    11641 cgggtacgcc ctcgcgcagc gcctcgacca ccgagttacg cccgacgacc agctcggagg
    11701 cgcccttgcc gccgcgccgc gcgaccgggc ggcgggccgc ggccttcttc tgggcggtcg
    11761 cgacgcggtt cttcttgtgc ttcttgcgca tctcggcggg cggggtcggg cccttgccct
    11821 caaggccgcg gcggcgcttc ccaccactgc cgacctgcgc gcccttcttg ttggacgtac
    11881 ggcggctgct gctgctcccg gccatgacct acctgattcc tgtttctgct gcgctgctgc
    11941 ttctgcttct ttttgacgct tctgccgctg cttctgcgaa tgtgcgttac gtgtctaggg
    12001 aaagtgtgcc ttccccgtgg ccctggtggc acatggagcg gtggctcagc gcgctccgag
    12061 actccagcgc ggcccgtccg ggccgtcctc gatgaccagt cctgacctgt tcagctggtc
    12121 gcggatggcg tccgcggtgg cccagtcctt gcgctccctg gccgcctcgc gctgccgcag
    12181 caccaggtgt acgagggtgt cgacggcgtc atgcaacgtc tgcgccgcac cggcctgggc
    12241 gctgccgccc tcgcccgccc agtgcgggtc cagcgggtca agcccgagca caccgagcat
    12301 ggcccgcacc tcggcgaggt gctggacggc ggcgtccttg tcgtcggcgg cgagggcgga
    12361 gttcccgtgc cggaccgtgg tgtgcagcac ggcgagcgcc tgcgggacac ccaggtcgtc
    12421 gtccatggcc tcggcgaagg cggccggcac ctcggcggcg ggctcgacgg ccccggcctt
    12481 ctcgacgacg cgctggacga acccctcgat ccgcgcgaac gcggactcgg cctcgcgcag
    12541 cgcctcctcg ctgtactcga tcatcgagcg gtagtgcggc gtgcccaggt agtagcgcag
    12601 gacgatcggc cgccagcgct ggaccatctc gctgaccagt acggagttac ccagcgactt
    12661 ggccatcttc tcgcccgcca tggtcaccca ggcgttgtgc atccagtacc cggcgaagtc
    12721 gtcgccgtac gccttggcct gcgcgatctc gttctcgtga tgcgggaaga ccaggtcgag
    12781 gccgccgccg tggatgtcga aggcggcgcc caggtacttg tgggccatcg ccgagcactc
    12841 caggtgccag ccgggccgcc cacggcccca cggggtctcc cagctgggct cgcccggctt
    12901 ggcggccttc cacatggcga agtctcgcgg gtcgcgcttg cccgtctcgc cctcgcccga
    12961 gggctggagc aggttgtcca gctcctggtt ggagagctgg aggtagccgt cgaaggagcg
    13021 cacgtcgaag tagacgttgc catcggcggc gtaggcgtgg ccgcgctcga tgaggccgcg
    13081 catcatctcc accatctcgg tgatgtgccc cgtggcgcgc ggctcatagg tgggcggcag
    13141 gcagccgagc gcgtcgtacc cctcgttgaa ggcgcgctcg ttctcgtacc cgatcgacca
    13201 ccaggggcgg ccctggtcgg ccgccttggc gatgatcttg tcgtcgatgt cggtgacgtt
    13261 ccgcacgaag gtcacgtcat agccgcggta ggtgaaccag cgacgcagga tgtcgaagtt
    13321 cagccccgac ctgatgtgcc cgatgtgcgg ggctgcctgc accgtcgcgc cacacagata
    13381 gatcgagacg cagcccggga cgagcgggga gaaatcacgg atctgccggg cgctggtgtc
    13441 atacagccga atagtcacgc gaccagggta gtgcgctcac ggcagtgccc cgcgccgcct
    13501 gtggataacc gtcacccgca cgtctggaca accgtcaccc gcacgtcgcc gctccccggt
    13561 cagccgcgca ccaccagggc cgtggcgatc gccgccaggc cctccgcgcg cccggtgagt
    13621 ccgaggccgt ccgtggtggt cccggagacc gagaccggcg cgcccacggc ggcggagagc
    13681 gtcttctgcg cctcgtcccg ccgcttgccg accttgggtc gtacgccgat cacctgaatg
    13741 gcgacgttgc cgatctcgaa tccctcggcc cggacgatcc gcgcggcctc ggtgagcagg
    13801 gcgactccgg acgctccggc ccactcgggc ctgccggtgc cgaagtgcgc cccgaggtcg
    13861 ccgattccgg ccgccgagaa gagcgcgtcg caggcggcgt gtgcggcgac atccccgtcg
    13921 gagtgcccgg cgagaccgta gcgctcgccc tcccacaaca acccggcgca ccacagctca
    13981 cggccttctt cgaaggcgtg tacgtccgtg ccgacgccga ccagcgggag ccgcgggggc
    14041 ggggcctgtg tctcagaagc cgccggtgtc tcagaagcca tcgttggccc tcctgcgtgc
    14101 gagtacggcc tcggcgaggg tcaggtccag cggccgggtg accttgaagg cctcctcgtg
    14161 ccctggcacg accacgacct ggacgcccag ttgctcaacc atgcccgcgt cgtcggtggc
    14221 gccctcgccg ttcagggcga cctgctcatg ggcgcggacc agggtctgcc ggtcgaagcc
    14281 ctgcggggtc tgtacggcgc gcagccgggc ccgctcgggc gtcgccacga ccggctcggg
    14341 cgcgccggga accgtcgcgg gttcgacctg cttgacggtg tcggcgacgg gcagcgcggg
    14401 aaccacggcc ggggctccgc cgcgtaccgc ctcgatgacc gcgtcgaccg tgtcgacggg
    14461 caccagcggg cgggccgcgt catgcaccag gacctcggtg atgccgggcg gcagtacgtc
    14521 gagaccggcc cgtaccgact cctggcgggt gtcgccgccg ggcacgacca cgtagtcggt
    14581 ggtctcgggc agcgcgtggg cgtcgaggag gttcttgacc tcggtggcgc cgtcgcgcgg
    14641 cgccaccacg acgaccagcg agacgccgcg ggagtcggcc atcgctcgta cggcgtggat
    14701 cagcatgggc agaccgctca gcgctcgcag cgccttgggg gcgccggggc cgaggcgtac
    14761 tccgcggccc gccgcgggga tgaccgcggc ggtggcgcgc ccgggggtgg gcacggcggc
    14821 gggcccggcg gtaggccgct cggaagcgtg ggattcgtct gacatctggt gcgcgttcag
    14881 gtttgtgtcc tcagccgacg tgggtatggc ctgggggtac cccctggtcg agcgacgtcg
    14941 aggccgtggg ggagtgccgg gcggaagcct ttgaccggac ccttccgtga cagccggtcg
    15001 agcgccagcg tcggagcccg gcacatcagg cagggtgagt gccaggccag gcagggtgag
    15061 cgcagggccg atggatcagg gcgcggggcc ggtagatcag cgtagatcag caaggtgggt
    15121 ggatgcagat gtgccgcagt gcccggcggc acagcatctt gtagcagagc tggccagcgg
    15181 gcaccgcggc atgtcttccc tagcgacgct aggacgcgag gacctcgtcg agcagggcct
    15241 cggccttgtc ttcgttggtg ttctccgcga gggcgagctc gctcaccaga atctgccgcg
    15301 ccttggcgag catgcgcttc tcacctgcgg acagcccgcg ctcacgctca cggcgccaca
    15361 ggtcacgtac gacttccgcg accttgatga cgtcgccgga ggcgagcttt tcgagatttg
    15421 ccttgtagcg acgggaccag ttggtgggct cctcggcata cggtgcgcgc agcacctcga
    15481 agacccggtc cagcccgtcc tgaccgacaa catcgcgcac gccgacgaac tccgcattgt
    15541 ccgctggcac acgaacagtc aagtcgccct gggcgacctt gagcaccaag taggtcttgt
    15601 ccacgccttt gatctgacga gtttcgatag cctcgatcag cgcggccccg tgatggggat
    15661 agaccacggt gtcgccaacc ttgaacgtca tgtgacaggt accccttccg tggctatcca
    15721 gggtaacacg agaacagcgt cttctgaatg gcgttttcgc aggtcagggc atatctcggg
    15781 gcttgacaac agcaacagga acgtgctgcg aaggcttagt ggaggcgggt attcgcaggt
    15841 gggagccgct ctccggggac gcggaaacag gcgcgtaacc ggccggaggc gtgctctcca
    15901 tgcggctgaa cgtcccggtt tgcacacttc gacggcaggg gcttccgcta ctccgttcgg
    15961 ttacaagaga ggcgtgcgag gcgggcgcgc gcggcagccc ccagcgaatc cggaattgat
    16021 catctcggac cctcatagcg atcatcgtga tgatcaattc atccggcctc ccccggatca
    16081 ccacgcattc cttacctgaa acccgaaagt caatatgtga aacccgtacg agggtccacc
    16141 cgcccacgag ccgaccgagg ctcctgatcg ctgagggtgg gtcgggtgcg gccgcccggg
    16201 gacggctcgg taacctgagc ccgccgaaag acctttaggg cagccttacg gtcggcccta
    16261 ccgtccacgc ttaggagttg ccgccgccgt gagccgcagc cttcgacgcg gcgccatcgc
    16321 cgctaccgcc ctcgcgttct cgctcgccgc tctcaccggg tgcggtgccg gaaacaacgc
    16381 gcagaccttg ggcgtccaac cggaccacgc cgcgacgtcg gtcggggaca tcaagatcca
    16441 gaactcgaca ctgatcaccc aggccgatcc cgagacggag ggccccgcgg tcgtcgccgt
    16501 caccctcttc aacgagggca gcaaggacca gaacctggaa gcgatcaagg tcgagggcat
    16561 cgacggggaa gccgacctca agcccgccga gggctccggg ccgatcaccg tcccggccca
    16621 cggcaccgtc gtgatcggcg gcaagggcaa cgcgtccgcc gtactggccg acggcaacgg
    16681 caccgtcctc gagggcaact cccagccgat caccttcacc ttcagcagga ccggcgacat
    16741 cacgctgcgt tccgcggtgg tcccggcgac cggccagtac gccgactggg gccccgaggc
    16801 cccgaaggcc ccggcgtccc ccaagccgac cgacaccgcc accgccgtcc ccgcggacga
    16861 ggacgaggac gaggccaccg acgggacccc cgacgaggcc accaccgagg ccacgccggg
    16921 cgctgacgcc acgggagagg ccacggagac tcccggcgcg ggcgcgacgg acgaggccgc
    16981 ccaggggccc gagggcgacg acgccgcgca ctgagagccg ccgagctcac ccccgcagcg
    17041 caccggaggg ccccaccgca cgaagcggtg gggccctccg ccgtaccagc caaacgacct
    17101 acggtccccg gcctatggcc ttcggcttcc ggcccacggc ctacggccta cggctcgaac
    17161 ttgtacccga gcccccgcac cgtcaccaga tagcgcggcg cccccgggtc cggctcgatc
    17221 ttggcccgca gccgcttcac atggacgtcc agggtcttgg tgtcacccac gtagtcagcg
    17281 ccccagaccc ggtcgatcag ctgcatccgg gtgagcaccc ggcccgcgtt gcgcagcagc
    17341 atctccagca ggtcgaactc cttgagcggc aggtcgacct tccccccgga gacggtgacg
    17401 acgtgccggt cgacgtccat ccggaccgga cccgcctcca gggcggccgg agagacctct
    17461 tccggttcgc cgcggcggcg cagcaccgcc cggatgcggg cgaccagctc gcgggacgag
    17521 aagggcttgg tgacatagtc gtcagcccct atctccagcc cgaccacctt gtcgatctca
    17581 ctgtccttgg cggtcaccat gatgaccggc acattggaga tgccccgcag ctggcggcag
    17641 acctccgtgc cgggcagccc tggcagcatc aggtcgagca ggacgaggtc ggcgccgttg
    17701 cgctcgaact cgtcgagccc gtcgggcccg gtggccgcga tggcgacttc gaaaccctcc
    17761 ttacggagca tgtacgacag ggcgtcactg aaggattcct catcctcaac gacgagcact
    17821 cgggtcacgg aaggacctcc ggggcaggaa gaggcccgcg ggtcgcgcga gcctgttcgt
    17881 tcgtggtgtc gtgcgtggtg tcgtgatcgg cggtgtcgcc gtcactgggg cggccctcgt
    17941 cgtcgaggcc cccggctatg agtggctttc tgcggtcgcg tacggatcct gcctcaggca
    18001 gtcgcagcgt aaaggtggag ccctgtccct cggagctcca cacggtgact tcgccgccgt
    18061 gtgaggcggc gacgtgcttg acgatcgcca ggccgaggcc ggtgcctccg gtggcgcggg
    18121 agcgcgccgg gtcgacgcgg tagaagcgct cgaagatgcg ttccctgtcc ttctccgaga
    18181 tgccgatgcc ctggtcggtg accgcgatct cgatcagatc gccgccaggg gcgttgaccc
    18241 ggcgcgcggc tatccccacg cgcgtacggg ccgggctgta gttcacggcg ttctcgacga
    18301 ggttgcccag ggcggcggcg agctggccgc ggttccccca gatgcgcagg tcgccgacgc
    18361 ctccggcggc catggtgatc tccttcgtac cggcctggtg tcggcagcgg tccatcgcct
    18421 cggcgacgag ttcgtcgacg cgtacggcct cggcgtcctc cagcgggtcg tcgttctgga
    18481 cgcgcgagag gtcgatcagc tcctggacca ggttggtcag gcgggtggcc tcgatctgca
    18541 tacggcccgc gaagcgctcc acggcctcgg ggtcgtccga ggcgtccatg acggcctcgg
    18601 agagcagcga gagggcgccg acgggcgtct tgagctcatg gctgacgttg gcgacgaagt
    18661 cgcggcgtac cgcttcgata cggcgggcct cggtgaggtc ctcgaccagc aggaggatca
    18721 gccgggagcc caggggcgcg acgcgggcgg agacggcgag cgcctcaccg cggccggtgc
    18781 cgcgccgcgg caggtcgagc tcgacctggc gtatctcgcc gtccctgcgg gtgtcacggg
    18841 ccatcttgag catcggctcg acggccagtt tcccgccgcg cacgaggccc agcgcgtacg
    18901 cggccgagct cgccttgacc acggcgtcgc cctcgtcgag tacgacggcc gacgagcgga
    18961 gtaccgagag cacggtgtcg acaccgggcg gcagtacggc gtcggtgtgc agggaggtcc
    19021 tggtggggcg tttctggtcg cgctcgctcc agcgaaacgc cagcatggcg atggcgccgg
    19081 tacacgctcc ggcgatcgct gcagctgcgg cgaccgccgc gttcacgtcc atggctccag
    19141 gttaggcatg ggataagccc cggccacagc gatgcctgtg tcatctcgga cactcgtcgc
    19201 cgagagttca ccatggatac gcggatggtt catttgggtg gtgcgaccgg cccggcgggc
    19261 cacaaggggg tgcgatcgcg gggcatacgg gaaccgtgag ccgtcgccca gagttcacct
    19321 cggtgacaga ggtgattcat atgagaggcc gttatcggtc gcgttgccgc tcgaacatgg
    19381 gagcgtgggg gtcatagccc cggcacgtat cacacgtatc aggaaaggga ccttccatgc
    19441 gggacgcgta ccacgaggaa ctggattcga tcggcgaggg cctggtcgag atggcccggc
    19501 tggtcgggtc ggcgatcggg cgcgccacga cggccatgct cgacgcggac ctgaagctgg
    19561 ccgagagtgt gatcgccggc gaccagaagg tcgacgatct gcagcatgac ctggaggcca
    19621 gggccatcgc cctgctggcc cgccagcagc cggtggcgac ggacctgcgc atcgtggtca
    19681 cctcgctgcg gatgagcgcc gacctggagc gctccggcga cctggcccag catgtcgcca
    19741 agctggcccg gctgcgcttc cccgagtcgg ccgtgccgaa cgacctgcac gccaccattc
    19801 tggagatggg ccagctggcc cagcgcctga tggcgaagtc ggccgaggtc atcatcacca
    19861 aggacatcga cttggcgctc cagctggagc aggacgacga cgagatggac ctgctgcacc
    19921 gcacgctctt caggcacctg atggacgacc gctggaagca cggcatcgag accgccgtcg
    19981 acgtgaccct gctcgggcgc tactacgagc ggttcgccga ccacgcggta tcggtcgcca
    20041 agcgggtggt ctacctggtg accggcgagc acgccgacga actgcaggcc gcgacggcgg
    20101 cggcgacggc gacggcgccg accgagggcg cgtaacgacg gccgcgctcc gggccctgag
    20161 cgttcgagcc ccgatgcgcc gttgatgcgc cctgctgggt gggcatgcaa tagggaaggt
    20221 cgtaagccaa ccgtgccttc gaggagggtc ccatggccga cacccccacg cccgacgccc
    20281 accaggacaa cgaccaggtc caagtgatcc acctgcccct gctcggtgcc tgcggctgcg
    20341 gcgcgggctg cggctgcggc tgccagtcgg gggcgccctg ccagtgcggc ggctgctgcg
    20401 gctgagccag agcgggcccg cagcacggaa tgagcccgca gcgtgaaaat gcccccgccc
    20461 cgcgccaaac gcgcggggcg ggggcatgat cgtggtgcct acttcttctt gccctggttc
    20521 ttgaccgcct cgatcgcggc cttcgccgcg tccgggtcga ggtaggtgcc gcccgggttg
    20581 aggggcttga actcggcgtt cagttcgtag gagagcggga tgccggtggg gatgttcagg
    20641 cccgcgatgt cggcgtcgga gatgccgtcg aggtgcttga ccagggcgcg cagggaattc
    20701 ccgtgcgcgg ccaccaagac cgtgctgccg gtgagcaggt ccgggacgat gccgtcgtac
    20761 cagtacggca gcatccgcgt gacgacgtcc ttgagacact ccgtccgcgg gcgcatctcc
    20821 ggcgggatcg acgcgtaacg cgcgtcgtcg ctctgcgaga actccgcgcc gtccgcgagc
    20881 ggcggcggcg gggtgtcgta cgagcggcgc cagagcatga actgctcctc gccgaactcc
    20941 gcgagggtct gcgccttgtc cttgccctgc agcgcgccgt agtgccgctc gttcaggcgc
    21001 caggagcggt ggaccggaat ccagtggcgg tcggctgcct caagcgccag gttcgcggtg
    21061 cggatcgcac gcttctggag cgaggtgtgc acgacatcgg ggagcaggcc gacgtccttg
    21121 agcagctcac cgccgcggac cgcctccttc tcgcccttct cgttgagatt gacgtccacc
    21181 cagccggtga acaggttctt cgcgttccac tcgctctcgc cgtggcggag gaggatcagc
    21241 ttgtacggtg cgtcggccat ggccctgagc ctaatcgaaa accagtagtg ccccgcctcg
    21301 gccgcccgta atctgcgtga gcgttgaaca ccacttacgc acgcacttac gcgcgcactt
    21361 acgcactcac gtacgcagag ccgggggcac ctcttgtcgt tcgcttctct cagacggtcc
    21421 gcgcgcgaga gcgtctcggg actgccgggc gggttctggt ggctctggct gtccacgctg
    21481 gtgaaccgta cgggcgcctt cgtgctcacc ttcatgtccc tgtacctgac ccaggaactc
    21541 ggctactcgg cctggtacgc ggggctcgtc atcgcgctgc acgggctcgg cggcatcgcc
    21601 gggtcgccgc tgggcgggat gctcagcgac cggtggggac gacggcccac gatgatcacc
    21661 gcgcatctgg gcggtgcggt ctgcgccgcc gcgctcgcgg tggtgaccag cgcctggggc
    21721 atcgccgtcg tggtgctgct gatgggtgtg gcgatgcagg cggtacggcc cgcgatcggc
    21781 gcgaccatcg cggacctggt tccggaggcc gaccgcaggc gggcctactc gctgaactac
    21841 tgggcactca acctgggctt cgccatcgcc gcgatgggcg gcggtgccgc gatcttcctc
    21901 ggctaccgga cgctgttcgt ggcggacgcg gtggcgaccg tactgtgcgc gctgatcgtc
    21961 ttcctgcggc tgggtgagac gcggcccgct cccgcctcca cgagcggcga tgcctcggcg
    22021 cgggccgcgg gcgaggcgaa ggcgaaggtg accacgttct cggtgctgcg tgatgacaag
    22081 gcgttccgga cgctggtcct gctcaacctg atggtgtgcc tggtcttcac ggctccgtgg
    22141 gtggggctgc cgctgaccat ggccgccaag gggcttgagc cgagcgcgta cggcatggtc
    22201 atcgcggtca acggcgtcgt gatcgtcgcc ttccagctgc tcgtcaacaa gatcaccgag
    22261 cggcgctccc cggccgccct gctcaccgtc tcctcgctgc tgttcgccct cgggacgggg
    22321 ctgaccgtgc tggcggggac gccactgctg ttcgccgcga ccgtcgtggt gtggacgatc
    22381 ggcgagatgg tgcacatccc caccaactcc gccgcgaccg cccggctggc cccggagcac
    22441 gcgcgcggcc gctaccaggg cgtgatgggc atgtcctggg cggtggcggg ctttgtcgcg
    22501 ccgatcctgg ccgggtgggt ggtggacggg cctggtccgg gcgcgctgtg gctggggtgc
    22561 ggggtgctcg ggagtgcggc ggcggtcggg tacgcggtgt tgctgcggcg ggcactgggc
    22621 acggaggaag gtgcggcgga gggcgcggcg gaggcggagg gcgcggcgga gagcgacgac
    22681 gtgcccgggg gcgtacgagg tgaagccgtg gccgatgccg cgtccgaagc cgggactgcg
    22741 tccgagcccg cgtccgaagc cgggaccgag ctcagttcgc gcgtggctgg gtgaggtgcg
    22801 cgaacgcgtc caggttgcgc gtcggctcgc cccgcgagac ccgccactcg tactccttac
    22861 ggatcgccga ggcgaagccc agctccagga gcgtgttgaa ggagccgtcc gccgcctcca
    22921 ggaccgaccc gagcagccgg tcaagctcct cggcggtcac cgcggacagc ggcagcttgc
    22981 cggtcaggta gacgtcgccg agctggtcga ccgcgtatcc gaccccgtac agcttgagat
    23041 tgcgctcaag gagccagcga tggacccctt cggcgttctc gtccgggtgc cggatcacga
    23101 aggcgttcag tgacagcgcg tgcttgccca cgatgagcga gaccgtggtg ctcagcttgt
    23161 gggtgccagg gagggtgacg acgtacgagc cgggctcggg actctcccac tcgacgtccg
    23221 cgtcggccag ggactgctcg atgatcgctg ctgcgtcagc catgtaccga gcgtagagga
    23281 cggtgcgctt cctgcatggc agcggtgtac acgtcggcgg tcccgagcgc cgcggtgtcc
    23341 cagccgaagg actgcgcgtg ccgcgcggcc gcctcgccca tccggtccac caggtgctcc
    23401 tcgtccacga accgctccag gacctgggcg tacgccgccg gatcgtgccc cgctacgagg
    23461 aagccgctga cctcgtcgcg tacggccacc ggcaggccgc ccacggccgc cgcgacgacc
    23521 ggcgtaccgg aggcctgggc ctcgatggcg acgagtccga aggactcgtt gtaggacgg
//
