LOCUS       NZ_WHOM01000077        25078 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces apocyni strain TRM 66233 521, whole genome shotgun
            sequence.
ACCESSION   NZ_WHOM01000077
VERSION     NZ_WHOM01000077.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces apocyni
  ORGANISM  Streptomyces apocyni
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 70538)
  AUTHORS   Liu,W.
  TITLE     Streptomyces poacynumensis sp. nov., a endogenous actinomycete
            isolated from Poacynum hendersonii
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 70538)
  AUTHORS   Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2019) Key Laboratory of Protection and Utilization
            of Biological Resources in Tarim Basin of Xinjiang Production &
            Construction Corps, Tarim University, Xingfu Road, Alar, Xinjiang
            843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABySS v. 2.2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009739465.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 17:09:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,397
            CDSs (total)                      :: 6,319
            Genes (coding)                    :: 6,205
            CDSs (with protein)               :: 6,205
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 34 of 114
            Pseudo Genes (incomplete)         :: 100 of 114
            Pseudo Genes (internal stop)      :: 6 of 114
            Pseudo Genes (multiple problems)  :: 23 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:56:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 45460
            Orig. end                         :: 70538
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHOM01000077.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25078
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25078
                     /SMILES="NC(C(O)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..25078
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:>25078](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..>25078
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            complement(54..509)
                     /locus_tag="GCN81_RS28435"
     CDS             complement(54..509)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025126.5"
                     /locus_tag="GCN81_RS28435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_156724777.1"
                     /transl_table=11
                     /translation="MALVEIQKAPSAYPVTQHSRPAIVAQFASTDCRACPSRTHCTSSR
                     RGSRILTLRPKELHEIQTAARAEQKTRTWRDKYELRAGVESTINQALDMTGIRRACYRR
                     LAKVRLQHLFSATALNVIRLDDDYWSTTPLSRPRTSRLEHLAYILTA"
     gene            complement(953..1159)
                     /locus_tag="GCN81_RS28440"
     CDS             complement(953..1159)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018839784.1"
                     /locus_tag="GCN81_RS28440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156724778.1"
                     /transl_table=11
                     /translation="MDLVVVLLVTVLVVIVALLAGAGAGKLARLDGATYPAALTRAAVA
                     FTAVLTLAAAVTAAYAALAALVA"
     misc_feature    complement(1144..1158)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            1278..3932
                     /locus_tag="GCN81_RS28445"
     CDS             1278..3932
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="GCN81_RS28445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_156724779.1"
                     /transl_table=11
                     /translation="MPETPEEGGPDAGDYGVFRRRLADRLANAQASSALSSKKQLADLA
                     GISRTTLHSALDPEGPLPLEHTVAALARELRLPVGELLTLRRTAAKAFSTRNASRGPTA
                     CVEDPEADPEPDAFASLRALAALPRTAETFVGREEEVRTLLAPLTPSAKDERQAARVQM
                     VVGMGGVGKTELVLQVAGRALAAPGWCPGGVLYADLNGYDPVAAQQAVATDVLDTFLRA
                     LGVVGEAVPPGVAARSALLRMLLAQRTAGGLRTLLVLDNASNESQVRPLLPGDGATPVL
                     VTSRTTLAIGARVHELGSLTAAASLELLRATLRQACGDEDTRVDDEIDAARAMTELCGG
                     LPLALHIVSGLLVDTARRPLSALAAALQDARTRLERLSHADQTVTAAFELSYRALTAEQ
                     AKLFRLLSLNPGPELSTAAAMSLLDATDAHDAERALQDLVRAHLAEPSTVWGRWRMHDL
                     LRLHAEEHGIACAAADGRDAARERLLGHYLRTTRAAVAQLPQQLVPPTAGFADRRQAMA
                     WLETERANLVAASLSAPQDSAAYGYLALALGAFFDRGRHYDDWITTGTQAASAFRACGA
                     VLQEAQALNFTGLALRQAGDVSQAVANHERALELFRQADDLHGQAQALNNLGLCHQQSH
                     QASLALREHREAAGMYKETGDIRGRAQALNNLGLAQCRIREFHQALATYERARTLFAEA
                     GDRYGDAQVLNNAGSCHREMREPAKAVVAHRAAAALYGELGDVHAEAGSWLNAGLTLNT
                     SRRPDEARPALERARDCYSDVGDAPGTANALNGLGAALLAQGQAQEALQAHASALTVFM
                     DLGDQAGQATTLSLRGLAQKNGEDRAGMLDSFRAAADLFHQLGDQAGEAAARAELSLDR
                     MRWATDFGGFEGA"
     gene            complement(4000..4401)
                     /locus_tag="GCN81_RS28450"
     CDS             complement(4000..4401)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037707.5"
                     /locus_tag="GCN81_RS28450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HD domain-containing protein"
                     /protein_id="WP_156724780.1"
                     /transl_table=11
                     /translation="MRGIDLGAWAEFESATWTSYPLLFRMLDDAADAAVLWDRILSSSQ
                     RAVIGEGLGVGEEQSRSLTVSLAGLRELGKLVPGFQQRERGAWERLGEDRVAGAGRISP
                     VPVEVDPYSMHVVFGVRDRRSGAWTSAVT"
     gene            complement(4822..5587)
                     /locus_tag="GCN81_RS28455"
                     /pseudo=""
     CDS             complement(4822..5587)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008745670.1"
                     /locus_tag="GCN81_RS28455"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAGVITASEPSWIAPFSGLSARQFGKLVTVLRRQGADAARKGRPW
                     RPSLEDRALLWPTGART"
     gene            5688..6101
                     /locus_tag="GCN81_RS28460"
     CDS             5688..6101
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946881.1"
                     /locus_tag="GCN81_RS28460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156724781.1"
                     /transl_table=11
                     /translation="MATETEVGELLHQRGWRTTFTVTQRVNAWAALVSVIERGYGDDIY
                     EYTNDLYCRNWLHEAWLLLDEHVVQLWTPRIKALDAQYKAATIDDDGQALDQFHRLPGP
                     DLWWWRRHPRILTGDLGRSLRSAGAIGADPDTA"
     gene            6456..6851
                     /locus_tag="GCN81_RS32060"
     CDS             6456..6851
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GCN81_RS32060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_197287817.1"
                     /transl_table=11
                     /translation="MSEFAAVIYAHQRLLRHPRANTAWATARAITTRWYDHQQHLTHRW
                     HTRLTRLCAANPHLATTGSASPALLTRDLVIYPETVALARALAALPNRPHRDTGKALNL
                     IADRLGLPRLASNANDPLRVFLTHTRH"
     gene            8295..9653
                     /locus_tag="GCN81_RS28470"
     CDS             8295..9653
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037531.5"
                     /locus_tag="GCN81_RS28470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HEPN domain-containing protein"
                     /protein_id="WP_156727429.1"
                     /transl_table=11
                     /translation="MGGEHHGAWWTPDAPDLRVPGSLTRTADGWRLSLIGTLMVNSGGW
                     DGLHLVPPHIIWGSCQGVPYTLLQCFLQSDVQGPDPSATHSASDQWTMTWRVEQLVRRG
                     EITESTRFRAVAFELTGLPASWPLSGLRGPQARSGPYAAPDDVTIPLDDGAIRIGVRDS
                     RRFGRRVKSLQEHVEVSADRRSGFTLDEVEKEIAGPLRALVAIGVDEPVSVFNLRLVPD
                     DPLTQGGPPRFLEVDPHDGEEPEEPAPTMHAPLPLSPSLDGMPSFIPAWLELARRCSVP
                     LDAVEPHRRPGSLQLQLLDVVNAAETLHRALHEELAEHPFAERVRRALDDAGGFNAAQR
                     RDVRDAVTVFMGITLEKRLLALAEELGPEVCQWLFNGTVKPWAYVTARIRNALSHGFTA
                     PDGVHEDPGALAGALHLTKAVITLRLLTEAGLPSGAVLTAQLDRHPGMRSLAK"
     cand_cluster    9336..21240
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    9336..21240
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[14335:16240](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(14336..16240)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            complement(9941..10498)
                     /gene="tpg"
                     /locus_tag="GCN81_RS28475"
     CDS             complement(9941..10498)
                     /codon_start=1
                     /gene="tpg"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828477.1"
                     /locus_tag="GCN81_RS28475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="telomere-protecting terminal protein Tpg"
                     /protein_id="WP_156727430.1"
                     /transl_table=11
                     /translation="MSVFGDGLDAAVQKAFTRPAPKSAGAQMRYLVKQLKGTKAVAQML
                     RISQRTVERYVKDQIKKPRPDLAARLEAEVKKRWQPQIRAKARQKAATTGGIVIDTRAR
                     IGYTAPIGTTDEDRLRHLTVALPPQHAARLFDAQEHGATDQQLQQIAAEALKEVYFQDN
                     GRRAGQLEEVHLTSIEHLEFDL"
     gene            complement(10505..>11101)
                     /locus_tag="GCN81_RS28480"
                     /pseudo=""
     CDS             complement(10505..>11101)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004994192.1"
                     /locus_tag="GCN81_RS28480"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="DGWYQRLRDAFLATMADLGVDAGMAPADFLAAMDGYRGRDPQLAI
                     VVSAVKATVKGGLGKLRERPRGEGWRPCEPWRALSRPTWRPDIRAAVISRTRINLHRKI
                     VKHAAFTGQYPVAVLSDCVVYAAGGTGPLDLLPYREGKPLPGGFKLGINPGLVKHEGTQ
                     SVLWGEEVRERFNAPELNLARYIKDGTVTDVDNGE"
     gene            complement(11171..12013)
                     /locus_tag="GCN81_RS28485"
     CDS             complement(11171..12013)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109742.1"
                     /locus_tag="GCN81_RS28485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_197287818.1"
                     /transl_table=11
                     /translation="MKRIEEILSRARLVRDRTVPPDRIPPARTTITSREPLPAGDAHAA
                     DSTCTTAAEDLRALCETLVTHTLADDVAEFVTEQLPQPRSAMILACVLQLTDTDDGARF
                     WWQYAAGGGQAAAAYCLYLHHLALGEKDAAHWWHQQTNDVHTPAGPGDQPAQPTPAAQP
                     WHPAGHQVTNASTTTMLRVLRHLAKRTARPPSAVVSELMAYIPTAVAAGYLRQPEMDLP
                     MPGPDFAHRISALLDAAEDRPAAPGTRPARQPLRTRTPLRPRPTASAQPAPMGESATR"
     gene            complement(12010..12912)
                     /locus_tag="GCN81_RS28490"
     CDS             complement(12010..12912)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109741.1"
                     /locus_tag="GCN81_RS28490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma factor-like helix-turn-helix DNA-binding
                     protein"
                     /protein_id="WP_156727431.1"
                     /transl_table=11
                     /translation="MTTPSEPPPSPARPAPLRPGRKLGPIADGVGTVHRAWLEPLRYTY
                     LKSGLTLSDLSVRVPLAKSKISELLRGTGLYPRWEIILSLSIQLKIPGWPLYRLWRQAA
                     LEAQKSSDWIERCSEKSSLTTSHTPPLDHRAFRELVENDYRLYAQVFLDDDQRDTAVCD
                     TFDILWLRWNEALASPDTRRFAWQTLRATVMARTPHIDGRPEFGTAAFDTIALRNLATE
                     AERMDQLGESLQLFTVMSRLPDQQLDVLVLRQLYGIRPEDVSALLGVSVATVRSGERHA
                     AHFLESVICPPPETEGDTA"
     gene            complement(12909..13259)
                     /locus_tag="GCN81_RS32615"
     CDS             complement(12909..13259)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GCN81_RS32615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_231627041.1"
                     /transl_table=11
                     /translation="MITWRNNSRTVQAGCSQGSGIGTRVLGGFTASGWAVGHMAGIEEL
                     LMGLKQILIIMATVFAWSLVMAAMGQTAAIAALAPVLGLVVQQLIRAARTQTGPTSGHR
                     ADAGPDKEGSAP"
     misc_feature    13478..13491
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            complement(13671..14339)
                     /locus_tag="GCN81_RS28500"
     CDS             complement(13671..14339)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.4"
                     /locus_tag="GCN81_RS28500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5825 family protein"
                     /protein_id="WP_156727432.1"
                     /transl_table=11
                     /translation="MSSAPTPLAVRAWRDYQDEVRRLPGMFLGSASVTGAVASTAEELY
                     ASGARRIELVEAVDLSSIGVPEAVVRTLRLLQELTARGIVVDWRLRLRLGDESTATALG
                     HLYPPREIDGCGDAARLRADWARTFFLGKCSYRHGPGFLEIRDHRSGVLQRIVIDEPEY
                     HAAISELTADAPAHPASPDALTDSILDALATESLTLSFGGLHWWAPCRIYRWPQPPFHV
                     "
     gene            complement(14336..16240)
                     /locus_tag="GCN81_RS28505"
     CDS             complement(14336..16240)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374931.1"
                     /locus_tag="GCN81_RS28505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_231627043.1"
                     /sec_met_domain="TIGR03975 (E-value: 3.9e-183, bitscore:
                     602.0, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVNMPWASLDTPSLALGILHAVVRPHVDDVITLCANVDFYDWAE
                     QTVDLTVDDYEYFAHHAYFEGFGDWVFSSALYDAPDWRTREFHEEMAAGVTDQLRKASL
                     RLHDLAPRFVAELAARIVEASPDVVGFTTTFQQNTAALATARQIKLLAPDTVTVFGGAN
                     CDGPQGEALHRNFPFVDHVVRGEAEDAFPALLEGLRGHADVAEIPGLCWRTEAGEPRVT
                     GMSAAPRSADRMAEPDFDAYFHRIERSSARPYIEPKLVLEGSRGCWWGEKHHCTFCGLN
                     GSSMQFRSKEPVDFLNSIVHQSRRHQVLDILVVDNILDMRYIHSLLPELAGLGYDYRFH
                     YEIKSNLHHRQLKTIAEAGLVQVQPGIESLSSRVLHLMRKGVTGCQNVRHLRDTQSAGV
                     WPVWNYLYGFPGETEADYTSVIRQMPALHHLPPPEAATRIAIERFSPYFDRPELGFADL
                     RPAAHYAHIYDLPESELHDLAYLFEAKHAGVDGVVVERLADAVAEWRAVHASCRLTHHD
                     LGDRMVLTSRRPHFDWTVRTIDDPVELAAFHLLGNPRSVGSLARRLTASLGTPVPEAHV
                     RRILADWREAGIVFEDADRFVHVAPLAANTELNRIEPSAPDLTQEFRRAEAPAARDMR"
     gene            complement(16386..19559)
                     /locus_tag="GCN81_RS28510"
     CDS             complement(16386..19559)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="GCN81_RS28510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_156727434.1"
                     /transl_table=11
                     /translation="MREFRVLGPIEVRRDGQAVRLNGRKARSLLAAFVLRGDHIVLTDR
                     LVEVLWGECPPPTAVAQVHKYVSGLRSALGQDRIVRHGHGYRLCLEQDQVDLLMFDRGV
                     AAARAARASGRQAEAARELRAALSLWRGVPLADTTDELQRAEAPALEERRIGALLEMIE
                     AELSLGRHTELVGELAGLVTANPLHEQLRGHLMLVLYRCGRVAEALAVYHEGRTLLAEE
                     LGIEPGTELQRLHQAILVMDPALHVDTGTTESAESVTLARSDADSDATPPAPAPTPARP
                     VPAQLPPSIADFTGRSDEVDQICTVLRAAHEDAPALVAIAGKGGVGKTTLAVHAARRVG
                     PDFPDGQLYVRLRDSQARPVEPKVALQGFLRAMGVDDPVIPDSLDECTRLFRSRSATRH
                     MLIVLDDATEEAQIRPLLPSSPDCAVLITSRTRLCGLEAAHHVHLEVFDSSDSVELFKR
                     IAGSDLPRDDQATTLEITQLCGHLPLAVRIAAARFAQHSRGDLAWFARRLTDERRRLDI
                     LVAGDLEVRANLAVSYQSLGVRERQAFCLLGLVNADDFAAWVLAPLLDTTVDEAEDIVE
                     ELVNSQLLDIVDSTIGGHTRYRYHDLVRLYARERAESECPEPERRAAFGRLLSFWVHLA
                     AEAGHRLYGTSPHGWSPQLSADSGHASPVAPCDVDWILRSPREWFEAERPALTSAIVEA
                     SARGFGSLAWALADSITDHLELCHRYDDWETTHTLALDACRQEGDTVGAGVMLMRLAGL
                     YLIRTDAAASLRSAERAEEVLEDAGHKVVIADALVAQAAALRVLGEHDRALERVRRALD
                     IARATSNLVAEARGTRELGTIHYERAQWDMSAQALREALTLGREVHNQREQALAMRYLA
                     VVLRHQEALDEARTYAQAARATFQDLNDQPYVAFTSLTLGLTLIQLDDPSAQSFVEEGV
                     ALLEEMDLGFGTAEALYVRAALDLAHNRGDRAIEQLIEAIGILDTRPVHNVLLSTVELL
                     GQALKATDDPERAATARGAVTTLSRLVGELPPSGLLASLTPGPGRKAEGAEPKVSRTSR
                     PHRTTGEDR"
     gene            20001..>25078
                     /locus_tag="GCN81_RS28515"
     CDS             20001..>25078
                     /NRPS_PKS="Domain: Condensation_LCL (30-330). E-value:
                     7.5e-97. Score: 315.9. Matches aSDomain:
                     nrpspksdomains_GCN81_RS28515_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (496-904). E-value:
                     1.1e-104. Score: 342.2. Matches aSDomain:
                     nrpspksdomains_GCN81_RS28515_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1015-1082). E-value: 2.3e-24.
                     Score: 77.4. Matches aSDomain:
                     nrpspksdomains_GCN81_RS28515_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (1111-1427). E-value:
                     1.3e-57. Score: 187.2. Matches aSDomain:
                     nrpspksdomains_GCN81_RS28515_Condensation_DCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="GCN81_RS28515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_197287819.1"
                     /sec_met_domain="Condensation (E-value: 1.3e-70, bitscore:
                     229.8, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-116, bitscore:
                     381.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.4e-12, bitscore:
                     40.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGIRKAEEAPRVRDVARPAPRAELTARPDERGPLSYGQQRLWFL
                     DRWLGSNAVYNIPVTLRFTGPLDADRLIAAVTLVASGHDALYTVFEEDQHGEPRQRLLD
                     SREPHCAFVDLTQLPTGARTAHAREAVEADARTPFDLAKDPMLRMALYRLAEDEYWLQL
                     TFHHIACDGWSLDVFERQLREAYEGGAGGQAAEPLPVQYADYALWQREVLEGPRAERAL
                     RAWEDALAGAPDLLDLGLDRPRPAELTYRGETTDFPLDDVSLGNLEAFAAAENVSLYTV
                     LLAAFQVLAARHSGSDDIVIGSPTAGRDQAQLNDLVGFFVDTLVLRTDLSDAPSFRELV
                     RRTHRSLLNALSRSKVPFDLAVKQLHPERSLSHNPVVQTLFAFHEEELSTSFGEGVAVE
                     RSMIPTGTAKFDLTWSLYRRPDGLLLQVEYATDLFDAATVRSLVDHWRVLLGEILAEPD
                     APVGRLRLMDATERSLVDAWAGRGGSFPVSSIHEAVVRRAVEAPDEVAVVCGGDSLTYA
                     ELVVRAGRVAEYLKGRGVGVETPVGVCVERSLETVVATLGVLLAGGVYVPLDTAFPADR
                     MRFMLEDVDAGLVLTQGSTVALVPDGPWEVVDLDSDGHLWAEGLTLERVANEVAVEVSA
                     DHACYVIFTSGSTGRPKGTTVAHGNVTRLFEAVRARLPFGKGDVWSLFHSFAFDVSVME
                     MWGALTSGGRLVVVPYITSRDADAFYALVRDERVTMLSQTPSAFRQFERADDATAGSEL
                     ALRAVLFAGEALDRSSVRRWGERHGYREPVLVNMYGITETTVHVTYAEVTEEQLDGAFT
                     LIGEALPDLRVYVLDPFGDPTPVGVVGELYVGGPGVTRGYIGRPELTAERFVPDHLGGE
                     PGARLYRSGDLARWRADGGLEYLGRGDSQVKVRGFRIELGEIEAALSRQPGIRQAVVIV
                     RDDLGEDQADLVAYLVPDDDATPSTSGLRDALADGLPAYMIPRNFVLLDELPLTPQGKL
                     DRRALPAPTGERPDLEVVFESARPGVEERLAGIWSQVLGVDRIGRHDNFFDLGGDSIRS
                     IQVLGQARALGMAFELQDLFRTPTLAGLAEAADASGDLAVPGRQREPFSMVSAEDRARL
                     PEGLEDAYPMAELQVGMIYEMELDRDRKPYHNVDSMRVSGQFDEAAFKRALALVVGRHP
                     ILRTALELSAYSVPLQLVHAEAEMPCFVADVRHLNEAAQEAAIAEYVLAQRQQTFDHAR
                     PPLLRVGIHDLTDDTFQWTVTEHHAIFDGWSLHSTLAEISGLYQRMLAGESVEAEPSPA
                     SAYRDFIAAEQAVLHSTESERFWLERVEDRPEGKLPRWPAEYDARLTPAVGENEWRASN
                     EAEKHGSIETLLPTELCEDLLAFAKKRGVPLKSVLLAAHLRVMSLVTGSTDVLAGVSSN
                     GRLEEVGSTEVRGLFLNTLPFRFKLPEGSWSDLVRAVFETEQEILPHRRYPLGVLQRKL
                     GVGSFLETQFVYNHFHILTDEFGKGRLEIMDGKIDSFSTMRSEPTNFPLSVGVIRNPYS
                     VRLLLCLDYHLGELVEDQVALVRDYYVRVLEAMVADPDASYGQVRVLGDDESSRLGLWA
                     GEGARFPVSSLHEAVVRRAVEAPDEVAVVCGGDSLTYAELVVRAGRVAEYLKGRGVGVE
                     TPVGVCVERSLETVVATLGVLLAGGVYVPLDTAFPADRMRFMLQDVDAGLVLTQG"
     aSDomain        20091..20990
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GCN81_RS28515_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="7.50E-97"
                     /label="GCN81_RS28515_Condensation_LCL.1"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="330"
                     /protein_start="30"
                     /score="315.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIACDG"
                     /tool="antismash"
                     /translation="ERGPLSYGQQRLWFLDRWLGSNAVYNIPVTLRFTGPLDADRLIAA
                     VTLVASGHDALYTVFEEDQHGEPRQRLLDSREPHCAFVDLTQLPTGARTAHAREAVEAD
                     ARTPFDLAKDPMLRMALYRLAEDEYWLQLTFHHIACDGWSLDVFERQLREAYEGGAGGQ
                     AAEPLPVQYADYALWQREVLEGPRAERALRAWEDALAGAPDLLDLGLDRPRPAELTYRG
                     ETTDFPLDDVSLGNLEAFAAAENVSLYTVLLAAFQVLAARHSGSDDIVIGSPTAGRDQA
                     QLNDLVGFFVDTLVLRTDL"
     aSModule        20091..23246
                     /complete
                     /domains="nrpspksdomains_GCN81_RS28515_Condensation_LCL.1"
                     /domains="nrpspksdomains_GCN81_RS28515_AMP-binding.1"
                     /domains="nrpspksdomains_GCN81_RS28515_PCP.1"
                     /locus_tags="GCN81_RS28515"
                     /monomer_pairings="Thr -> Thr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       20157..20270
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0001"
                     /evalue="3.90E-09"
                     /label="C2_LCL_024-062"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="90"
                     /protein_start="52"
                     /score="28.9"
                     /tool="antismash"
                     /translation="AVYNIPVTLRFTGPLDADRLIAAVTLVASGHDALYTVF"
     CDS_motif       20493..20558
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0002"
                     /evalue="2.80E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="186"
                     /protein_start="164"
                     /score="29.4"
                     /tool="antismash"
                     /translation="FHHIACDGWSLDVFERQLREAY"
     CDS_motif       20601..20639
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0003"
                     /evalue="3.50E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="213"
                     /protein_start="200"
                     /score="19.4"
                     /tool="antismash"
                     /translation="QYADYALWQREVL"
     CDS_motif       20892..20981
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0004"
                     /evalue="2.60E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="327"
                     /protein_start="297"
                     /score="45.5"
                     /tool="antismash"
                     /translation="DIVIGSPTAGRDQAQLNDLVGFFVDTLVLR"
     CDS_motif       21033..21149
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0005"
                     /evalue="6.50E-13"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="383"
                     /protein_start="344"
                     /score="41.0"
                     /tool="antismash"
                     /translation="RSLLNALSRSKVPFDLAVKQLHPERSLSHNPVVQTLFAF"
     aSDomain        21489..22712
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GCN81_RS28515_AMP-binding.1"
                     /evalue="1.10E-104"
                     /label="GCN81_RS28515_AMP-binding.1"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="904"
                     /protein_start="496"
                     /score="342.2"
                     /specificity="substrate consensus: Thr"
                     /tool="antismash"
                     /translation="RAVEAPDEVAVVCGGDSLTYAELVVRAGRVAEYLKGRGVGVETPV
                     GVCVERSLETVVATLGVLLAGGVYVPLDTAFPADRMRFMLEDVDAGLVLTQGSTVALVP
                     DGPWEVVDLDSDGHLWAEGLTLERVANEVAVEVSADHACYVIFTSGSTGRPKGTTVAHG
                     NVTRLFEAVRARLPFGKGDVWSLFHSFAFDVSVMEMWGALTSGGRLVVVPYITSRDADA
                     FYALVRDERVTMLSQTPSAFRQFERADDATAGSELALRAVLFAGEALDRSSVRRWGERH
                     GYREPVLVNMYGITETTVHVTYAEVTEEQLDGAFTLIGEALPDLRVYVLDPFGDPTPVG
                     VVGELYVGGPGVTRGYIGRPELTAERFVPDHLGGEPGARLYRSGDLARWRADGGLEYLG
                     RGDSQVKVR"
     CDS_motif       21666..21707
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0006"
                     /evalue="3.40E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="569"
                     /protein_start="555"
                     /score="14.0"
                     /tool="antismash"
                     /translation="LGVLLAGGVYVPLD"
     CDS_motif       21840..21887
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0007"
                     /evalue="4.90E+00"
                     /label="C3_dual_135-156"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="629"
                     /protein_start="613"
                     /score="0.6"
                     /tool="antismash"
                     /translation="HLWAEGLTLERVANEV"
     CDS_motif       21915..21974
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0008"
                     /evalue="2.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="658"
                     /protein_start="638"
                     /score="26.1"
                     /tool="antismash"
                     /translation="CYVIFTSGSTGRPKGTTVAH"
     CDS_motif       22500..22589
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0009"
                     /evalue="4.30E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="863"
                     /protein_start="833"
                     /score="57.3"
                     /tool="antismash"
                     /translation="PVGVVGELYVGGPGVTRGYIGRPELTAERF"
     CDS_motif       22677..22742
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0010"
                     /evalue="8.30E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="914"
                     /protein_start="892"
                     /score="37.0"
                     /tool="antismash"
                     /translation="YLGRGDSQVKVRGFRIELGEIE"
     aSDomain        23046..23246
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GCN81_RS28515_PCP.1"
                     /evalue="2.30E-24"
                     /label="GCN81_RS28515_PCP.1"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="1082"
                     /protein_start="1015"
                     /score="77.4"
                     /tool="antismash"
                     /translation="EERLAGIWSQVLGVDRIGRHDNFFDLGGDSIRSIQVLGQARALGM
                     AFELQDLFRTPTLAGLAEAADA"
     aSDomain        23334..24281
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GCN81_RS28515_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.30E-57"
                     /label="GCN81_RS28515_Condensation_DCL.1"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="1427"
                     /protein_start="1111"
                     /score="187.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHAIFDG"
                     /tool="antismash"
                     /translation="EDAYPMAELQVGMIYEMELDRDRKPYHNVDSMRVSGQFDEAAFKR
                     ALALVVGRHPILRTALELSAYSVPLQLVHAEAEMPCFVADVRHLNEAAQEAAIAEYVLA
                     QRQQTFDHARPPLLRVGIHDLTDDTFQWTVTEHHAIFDGWSLHSTLAEISGLYQRMLAG
                     ESVEAEPSPASAYRDFIAAEQAVLHSTESERFWLERVEDRPEGKLPRWPAEYDARLTPA
                     VGENEWRASNEAEKHGSIETLLPTELCEDLLAFAKKRGVPLKSVLLAAHLRVMSLVTGS
                     TDVLAGVSSNGRLEEVGSTEVRGLFLNTLPFRFKL"
     CDS_motif       23409..23513
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0011"
                     /evalue="9.30E-11"
                     /label="C2_LCL_024-062"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="1171"
                     /protein_start="1136"
                     /score="34.1"
                     /tool="antismash"
                     /translation="YHNVDSMRVSGQFDEAAFKRALALVVGRHPILRTA"
     CDS_motif       23742..23804
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0012"
                     /evalue="2.40E-04"
                     /label="C3_DCL_135-156"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="1268"
                     /protein_start="1247"
                     /score="13.8"
                     /tool="antismash"
                     /translation="HHAIFDGWSLHSTLAEISGLY"
     CDS_motif       24966..25007
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GCN81_RS28515_0013"
                     /evalue="3.40E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="GCN81_RS28515"
                     /protein_end="1669"
                     /protein_start="1655"
                     /score="14.0"
                     /tool="antismash"
                     /translation="LGVLLAGGVYVPLD"
ORIGIN
        1 cgccagcggg tggaacggca cgactccgtt gcccaattcc gagcggtcgc cggtcaggct
       61 gtgagtatgt aggcaaggtg ttcgagtctg ctggtccggg gtctgctgag cggggtggtg
      121 ctccagtagt cgtcgtcgag gcggatgacg ttcagggcgg tggcggagaa gaggtgctgg
      181 aggcggacct tggccagtct tcggtagcag gcgcggcgga ttccggtcat gtccagggcc
      241 tggttgatcg tgctctcgac cccggcgcgc agttcgtact tgtcccgcca ggtccgggtc
      301 ttctgctcgg cgcgggcggc agtctggatc tcgtgcagct ctttcggccg cagggtgagt
      361 atccgactgc ccctccggga ggaggtgcag tgcgtccttg acgggcaggc ccggcagtcg
      421 gtggaggcga actgggcgac gatggcgggc ctgctgtgct gggtaaccgg atacgctgat
      481 ggcgctttct gaatctcaac gagcgccatc agcccgtcct gatgggccac aacgccactc
      541 ccccggcggc cagggccaat ccgctagcgc accgatctca cccgccatga ccaaaatcaa
      601 ccacgcaaac cagtcttgcg gacaggcaaa actgcggggg gctctgatag cgtcccagct
      661 cagcaagtct ccgccccgca cgcgcaggga tgacacccag gcggcggaac cagggcccct
      721 tttcgccctc tccgccccgc acgcgcaggg atgacactca gttgctgccc agccacacat
      781 gagctcggcg ctccgccccg cacacgcagg gacgattgcc aacaatgggc acgcagtccc
      841 acgcaagctc accgagcgta ccggcggagg cgcgccgacc ctgcagcacg gtgcccgacc
      901 cccacaccgg gctggaaggc ccgcggccgc tcgtcccgag gtgcgggtcc gttcaagcga
      961 ccagggcggc gagggccgcg taggcggcgg tcacggcggc ggcgagggtg agcaccgcag
     1021 taaaggccac ggcggcccgg gtgagggcgg cagggtaggt ggcgccgtcc aggcgggcga
     1081 gcttgcctgc accggccccg gccagcagcg cgacgatcac cacgagcacg gtgaccagca
     1141 gaacgacaac gagatccacg acaatctccc tgtgatggcg gggtgttgac gtgatctaag
     1201 ctcccggaat cagtgttcag cggggttcac ccggacgaga atggacacgg ccgaacacgt
     1261 gacaacgcgg gggaacgatg cctgagacgc cagaagaggg aggtccagac gccggtgact
     1321 acggggtgtt ccgccggagg ctggccgacc ggctggccaa cgcccaggcc tcctccgcgc
     1381 tgtcgagcaa gaagcagctg gccgatctgg ccggcatatc gcgcacgact ctccactcgg
     1441 cgctcgaccc cgagggtccg ctgcccttgg agcacaccgt ggccgcgctg gcccgcgagc
     1501 tgaggctacc cgtcggcgag ctcctcacgc tgcgccgtac ggcagcgaag gccttcagca
     1561 cccggaacgc ctcccgtggc ccgacggcat gcgtcgagga ccccgaagct gaccccgaac
     1621 cagatgcctt cgcgtccctt cgggccctgg cggctctgcc ccggaccgcc gagacgttcg
     1681 tcggccgcga ggaggaggtg cgtacgcttc tagcgccgct caccccctct gccaaggacg
     1741 aacgtcaggc agcacgggtc cagatggtcg tcggcatggg cggcgtgggc aagaccgaac
     1801 tggtcctcca ggtcgcaggc cgggcgctgg ccgcacccgg ctggtgtccc ggtggcgtgc
     1861 tgtatgccga cctgaacggc tacgacccgg tggctgcgca gcaggccgtc gccaccgatg
     1921 tcctggacac ctttctcagg gccttgggcg tcgtcggtga ggccgttccc cctggcgtcg
     1981 cagcacgatc cgcccttctg cgtatgctcc tggcgcaacg gaccgcgggc gggctgcgga
     2041 ccctgctggt tctcgacaac gccagcaacg agtcgcaggt ccggccgctg ctgccgggtg
     2101 atggagccac ccccgtcctg gtgacctcac gcaccacttt ggccatcggc gcccgtgtac
     2161 acgagctcgg ctccctgaca gccgccgcct cactcgagct gctccgggca acactgcgcc
     2221 aggcatgtgg ggacgaggac acccgggtcg atgacgagat cgacgcggcc cgcgcgatga
     2281 ccgagctgtg cggtgggctg ccgctggcgc ttcacatcgt ctcggggctg ctcgtcgaca
     2341 ccgcgcgtcg cccgctttct gctctggccg cggccctaca ggacgcacgg accaggctcg
     2401 aacggttgag ccatgcggac cagaccgtca ccgccgcctt cgaactctcc taccgcgcgc
     2461 tcaccgcgga gcaggcgaag ctgttccggt tgctgtcgct caatcccggc ccggagctct
     2521 ccaccgcagc ggccatgagc ctgttggacg ccaccgacgc ccacgatgcg gagcgcgccc
     2581 tgcaggatct ggtgcgggcg caccttgcgg agccttccac ggtgtggggc cgctggcgca
     2641 tgcacgatct gctgcgactg cacgctgagg agcacgggat cgcgtgtgcg gccgcggacg
     2701 ggagggatgc cgcccgcgag cgcctgctag gccactacct gcgcacgacc cgcgccgccg
     2761 tcgcccagtt gccccagcag ctcgtccctc cgaccgcggg cttcgcggac cgacggcagg
     2821 cgatggcctg gctggagacg gaaagggcga atctggtcgc ggcgtcactc agcgcgccgc
     2881 aggacagtgc ggcgtacgga tacctggcct tggctctggg cgctttcttc gatcgggggc
     2941 gtcactacga cgactggatc acgacgggca cgcaggcagc gtcagcgttc cgcgcctgcg
     3001 gcgcggtact ccaagaggcc caggccctca atttcaccgg cctcgcccta cgtcaggcgg
     3061 gcgacgtctc tcaggcagtg gcaaaccatg agcgcgctct ggaactgttc aggcaggcgg
     3121 acgacctgca cggtcaggcg caggcgctca acaacctcgg gctgtgccac cagcagtcgc
     3181 accaggcctc cctggcgcta cgtgagcacc gggaggcggc cggcatgtac aaggaaacgg
     3241 gcgacattcg cggccgggct caagccctca acaacctggg gctcgcccaa tgtcgcatcc
     3301 gcgagttcca ccaggcgctc gcgacgtacg agcgagcccg gacactgttc gccgaagcag
     3361 gcgaccggta cggcgacgcc caggtactca acaatgcggg ttcgtgccat cgggagatgc
     3421 gggagccggc gaaggcggtc gtcgcgcatc gggccgcagc cgcactctac ggcgagctcg
     3481 gagacgtcca cgctgaggca ggttcctggc tcaacgcagg gctcaccctc aacaccagca
     3541 ggcggccgga cgaggcacgg ccagcgctgg agcgcgcccg cgactgctac agcgacgtgg
     3601 gcgacgcacc gggcactgca aacgcgctga acggtctggg ggcggccctc ttggcccagg
     3661 gacaggcaca ggaggcactg caggcccatg cttcggcact gaccgtcttc atggacctgg
     3721 gggaccaggc cggccaggcg acgacactga gcctgcgggg cctggcgcag aagaacgggg
     3781 aggatcgggc agggatgctg gattccttca gggcagctgc cgaccttttc caccagctcg
     3841 gggaccaggc cggagaggca gctgcccgtg ccgaactgtc cctggaccgc atgcggtggg
     3901 cgacggactt cggcggcttc gaaggcgcgt gaaccgtagc cccccaccaa ggctgtgccc
     3961 ctgccggaca tatcgagggg cgggcgagga actcaaggac tacgtcactg cactggtcca
     4021 ggcgcctgat cgcctatctc gcacaccgaa caccacgtgc atcgagtacg ggtctacctc
     4081 caccggtacc ggcgagatac ggcccgcccc ggccacgcga tcctcgccca gccgctccca
     4141 cgcgccacgc tcacgctgtt ggaagcccgg caccagcttg cccagctccc gcaagcccgc
     4201 cagtgacacc gtcagcgacc gcgactgctc ctcgcccaca cccaggcctt cgccgatcac
     4261 cgcacgctgc gacgagctca agatcctgtc ccacagcacc gctgcatccg ccgcgtcatc
     4321 cagcatccgg aacagcagcg gatacgacgt ccaagtcgct gactcaaact ccgcccacgc
     4381 cccgaggtcg ataccgcgca tcctcaacca cccccaccca cagtcccctt cagccgcatt
     4441 cgcgcttacc tgcaccaatc gatcacgtaa cgaccagtac actagactta cttcacgtca
     4501 ccgatgacgc acacggccca ccccgcacac gctgggatga ttcgaccgag ccgcgtccgc
     4561 cggatcagga ggcgtactcc gcccagcaca ggcagggatg actcctgctc acccgggagc
     4621 cgcaggttct gcccgtatac tccgccccgc acgcgcaggg atgactcacg gcggcatcag
     4681 gcctgtggtc tcagtggcat ctccgccccg cacgcgcagg gttgactcag cgcagaagag
     4741 gcagaccggc atcgaagtgc tgtcccgtaa atgatcttcg ggttgcctcg ggcatggttg
     4801 gccgctgtgc ggcccgctcg cttatccggc gagggcgagg ctgtgcatcc gggcgagccg
     4861 agcatggcgt gatggacgcc gtcgcctttg aggcggcagt cgcggaggat cttccatgtc
     4921 ttcatgcggg cgaaggcgtg ctcgacgcgg gctcggacct gctcgtggga cttgttgtgt
     4981 tcctctttcc agtccgggag tccggcctgg ccgcgctcgc ggcggtgcgg gatgacgagt
     5041 ccggtgcccg ggtagccgcc gtcggcgatc gtcatagtct tgccgacgac ggccttggcg
     5101 ccggactcct cccatgcctt gcagtcgttg cggttcccgg cgagcggccg gccgaccacg
     5161 acgaccaggc gggtgtcggc gtcgatgacg acctggtggt tggtggagta ccggtagttc
     5221 ttcgaccgct cggcaatggt gtggtcgcgg gtggggacca gggtgccgtc cacgatgagc
     5281 acggtgtccc tggcgaacct cttgcggggc tgaagcgcga gcatcggccc gaggtggtca
     5341 atgatgcggt ccgccgccga cttggacacc ccgaacagcg gggcgagttg ccgcatggtc
     5401 aggttcgtgc gccagtaggc cacagcaggg cccggtcctc cagagaaggg cgccacggcc
     5461 ggcccttgcg ggcggcgtcc gcaccctggc gccgcagaac ggtcaccagc ttcccgaact
     5521 gcctcgcgct cagcccgctg aacggggcta tccaggacgg ctccgacgcc gtgatcacac
     5581 cagccacggc gagatcgtct catcttgatc atgctgcggg gcacgccagc ctctgacggg
     5641 acacatctcg gtcgcccgga cggattcggc atgagagcct cacgcccgtg gctactgaaa
     5701 ccgaggtggg agagctgttg caccagcgcg gctggcggac gacattcacg gtcacccaaa
     5761 gggtgaacgc gtgggctgcc ctggtgagcg tcatcgagcg cggctacggc gacgacatct
     5821 acgagtacac caacgacctc tactgccgaa actggctgca cgaagcgtgg ctcctgctgg
     5881 acgaacacgt cgtccagctc tggaccccgc ggatcaaagc cctggacgcc caatacaagg
     5941 ccgcgaccat cgacgacgac ggccaagcac tcgatcagtt ccacaggctg cccggccccg
     6001 acctgtggtg gtggcggcgc cacccccgca tcctcaccgg agacctcggg cgttcgcttc
     6061 gctcggccgg cgccatcggc gccgatccgg acacggcatg accctcagcc tcgtgggatt
     6121 acgagacagc acttagccga attccgccca gctggaagaa cctgcaggtc aagtagggtt
     6181 aactatcggc attctcactt caatgtcctg cagtttccca tctgacgtca catcaacttc
     6241 tcaccggctg ccgcccttga ttctgccgag gatcagcaaa tgagcacgtg acaagggctg
     6301 cagcaacagc ggaacatatg acgtcgagct gagaacttcg ccggacatca aagtgagact
     6361 cagcaattca accggcgccg caccggctgg tgtgcccacg gcatcagcaa gccgcccccg
     6421 gcccacgact cacctcccct atccgcacag gggccgtgtc agaattcgcc gccgtaatct
     6481 acgcccacca gcgcctcctg cggcacccgc gtgccaacac cgcctgggcc acagcgcgcg
     6541 ccatcaccac ccgctggtac gaccaccagc aacacctcac ccatcgctgg cacacccgcc
     6601 tgacccggct ctgcgcggcc aacccccacc tggccaccac gggcagtgcc tcccccgccc
     6661 tgctgacccg cgacctggtg atctacccgg aaaccgttgc cctcgcccgt gcactcgccg
     6721 ccctcccgaa ccggccacac cgcgacaccg gcaaagccct caacctcatc gccgaccgac
     6781 tcggactgcc ccgcctggcc agcaacgcga acgatcccct ccgggtcttc ctcacccaca
     6841 cacgccactg accagcatca tccggaaccc caaacccccc gagagcgcag cccgcctata
     6901 gacgcgccac cacacctacg agaaagccaa gatcaatccc acacaactac tgaaccgcag
     6961 gccaagcgcc cgaacaacca aaccgaacgc acacccagtc cacgcccatc acgcccgaac
     7021 gcaaccactt cagccgtccc gagtcccact ccaaagacga aacaccagac caaagcagtc
     7081 cagcgccctg aagatcactg ctccgtcaca gtccaggccc agctcgctga ggggatccgg
     7141 ccaacgcgac ccggcaacct caggctcccg cccagtcagc aaagcccgcc ccgcccgacg
     7201 gtccctgcgg atcacccgat gcaacgtcga cgccgacggc accgaaaccc cgccaccagc
     7261 atcgaccagc cgacgcctca gctcagcgac attccctccc acctcgccaa gcagctccca
     7321 cacctcgtcc gacaccgcgt acccctgccg gaccggcgtc tccacacgcc ccgtcgcctt
     7381 cgcctgcccc agccagcgcc acaccgtacg ctccgaaaca cccaccacct ctgcgaccgc
     7441 acgcacatgc cgcgtcgaca actcccccgc ctgctgccgc tccagcaaac gacgcaccac
     7501 caacgccctc ggcagcccag ccccccgacc ggcccctaca ccctgatcca ccccacgatc
     7561 acaccggccc ggcccaccgc atcgcatcag aactcacgaa actgagacag catcagctgc
     7621 catgggataa agccccacga cagcaacacc cacccacggc ctctcacctc atgacagtgc
     7681 cgacctcgcc ccaacacccc actgaccagc gccaacacaa aacaacacca gaccagcacc
     7741 accgactctc accattactg accccaagcc gagagatcgc accaagacga gacgcgacaa
     7801 gctcacccag gaccagctgt acgcactgcg ggagttgggc atcgaatggg catagccgga
     7861 aggaactggg cgtggaatgg gcgtgacacc acggctcgtt gcactggctg gacacaccga
     7921 cgtatgaagt gaccccgcga gtcgtggccc ggggcttcgt gctctcggcg gtagaggacg
     7981 cccaccgaga cgccctggct ggcgtccgct gccgggtcat ctgcagatcg aagaattgag
     8041 caccgacacc accagcatga gcccgtatac ggcgttgatg cgcgtgtact gaacgcgcga
     8101 tacgccgtgg cactcgggtg ccggccgaat acgcgcggga tgcagaggga tgggattctg
     8161 gtccgccagg ccgcctcagc acctccggtt tccgtcacag cgggcagggc cttccgcctg
     8221 tgcatgcggc gatacgcctg ccccagtggg aaggtagacg tgtcctgcgc gaatagatct
     8281 ttaaaggggg acacgtgggt ggagagcatc atggcgcatg gtggactccg gatgcgccag
     8341 atctgcgggt gccgggttcg ctgacccgca ccgcggacgg atggcgcctg agcctcatcg
     8401 gcaccctgat ggtgaactcg ggcggctggg acggccttca ccttgtccca ccccacatca
     8461 tctggggatc ctgtcagggc gtcccgtaca ccctgctgca gtgcttcctg cagtctgacg
     8521 tgcagggacc ggaccccagc gcaacccaca gcgccagcga tcagtggacc atgacctggc
     8581 gcgtcgagca gctggtccgc aggggtgaga tcaccgagtc gacccgcttt cgtgcagtgg
     8641 cgttcgagct caccggcctg ccggcctcgt ggcctttgag cgggctgcgc ggcccgcagg
     8701 cgcgttccgg accctacgca gcgcccgacg acgtgaccat ccccctggac gacggagcga
     8761 tccgcatcgg tgtccgggac agccgccgct tcggccgccg ggtgaaatcc ctgcaggaac
     8821 acgtggaggt cagcgccgac agacgttcag gcttcaccct ggacgaggtg gagaaggaaa
     8881 tcgcaggccc cctgcgggcc ctggtcgcca tcggggtcga cgagccggtc agcgtgttca
     8941 acctgcgcct cgtgccggac gatcccctca ctcaaggcgg gccgccgcgc ttcctcgaag
     9001 tcgaccctca cgacggcgag gaacccgaag aacctgcgcc gacgatgcac gccccgctgc
     9061 cgctgtcccc ttccctggac ggcatgccat cgttcatccc agcgtggctg gagctggccc
     9121 gccgctgctc cgttccgctg gacgcagtag agccccaccg acggcccggg tccctgcaac
     9181 tgcagctcct ggacgtcgtc aacgcagccg agacactcca tcgcgctctt cacgaggaac
     9241 tggcggagca tcctttcgcg gaacgcgtgc gcagggcgct cgatgacgcg ggaggcttca
     9301 acgctgccca gcgccgcgac gtacgtgacg cagtcacggt attcatgggc atcacgctgg
     9361 aaaagcgcct cctggccctg gccgaagaac tcgggcccga ggtatgccag tggctcttca
     9421 acggcacagt caaaccgtgg gcctatgtga cagcccgcat ccgcaacgca ctgagccacg
     9481 gcttcaccgc ccccgacgga gtccacgaag atcccggggc gctcgcgggc gcgctgcatc
     9541 tgaccaaggc cgtcatcacg ctccggctcc tcaccgaggc cggcctgccc tcgggcgcgg
     9601 tcctgaccgc acagctcgac aggcaccccg ggatgcgctc cctggccaag tagagcatcg
     9661 ccgactggcc cgcactggcc caccgcgtca gcccaaacca gtggccgcgg ccccaacccg
     9721 aacgccccga ggaccaatcg gcatcgtcag agagcgcggg tgagatgccg cacggcgccg
     9781 agggcagccc gcagttgccg gagtgacggg cgcgacaaca ccttcgccgc gcacggggcc
     9841 gactgtgtgg ccccgccacg ccccatactc aagcgtcggc aggcaggcca ggccggtgcc
     9901 gagcatgatg cggtcgacgg ggctcgcggc tgttcgagat ctacaggtcg aactcgaggt
     9961 gctcaatgct ggtgaggtgg acctcctcca gctggccggc gcggcggccg ttgtcctgga
    10021 agtacacctc cttgagtgct tcggcggcga tctgctggag ctgctggtcc gtggcgccgt
    10081 gctcctgggc gtcgaagagg cgggcggcgt gctgcggcgg cagagcgacc gtgaggtgtc
    10141 ggaggcggtc ctcgtccgtc gtcccgatcg gcgcggtgta gccgatccgg gcgcgggtgt
    10201 cgatgacgat gccgccggtg gtcgccgcct tctgacgcgc cttggcacgg atctgcggct
    10261 gccaccgctt cttcacttcg gcctccaagc gggcggcaag gtccgggcgg ggctttttga
    10321 tctggtcctt cacgtaccgc tctacggtgc gctgggagat ccgcagcatc tgggcgaccg
    10381 ccttggtgcc cttgagctgc ttgaccaagt accgcatctg cgcgcccgcg ctcttgggcg
    10441 ccgggcgagt gaacgccttc tgcaccgcgg cgtccaggcc gtccccgaac acgctcatcg
    10501 cccactactc cccgttgtcg acgtcggtga cggtgccgtc cttgatgtac cgggcgaggt
    10561 tgagctccgg cgcgttgaac cgctcgcgga cctcttcgcc ccacagcacg ctctgggtgc
    10621 cctcgtgctt gaccaggccc gggttgatgc cgagcttgaa cccgccgggc agcggcttgc
    10681 cctcccggta gggcagaagg tccagcgggc cggtgccgcc tgccgcgtag acgacgcagt
    10741 cggacaggac cgcgaccggg tactgccccg tgaacgccgc atgcttgaca atcttgcggt
    10801 ggaggttgat ccgggtgcgg gagatgacgg ccgcgcggat gtccggccgc cacgtcgggc
    10861 gggacagcgc ccgccacggc tcacacgggc gccagccctc gccacgcggc cgctcgcgca
    10921 gcttgcccag accgcccttc accgtcgcct tgaccgccga gacaacgatc gccagctgag
    10981 ggtcacggcc gcggtagccg tccatcgccg ccaggaagtc agccggcgcc atgcccgcgt
    11041 ccacgccgag atcggccatc gtggcgagga aagcatcacg cagccgctga taccagccgt
    11101 cccctttgtg acgactcgtg gatggcgctg gccacggcag gaaaagaggg ggcgcggtgg
    11161 gcgcgggtgg tcaacgtgtg gcgctttctc ccatcggcgc gggttgtgct gatgcggtgg
    11221 ggcgtggtcg caggggggtg cgggtgcgga gcggctggcg ggcggggcgt gtgccggggg
    11281 cggcgggtcg gtcttcggcc gcgtccagga gggcgctgat gcggtgggcg aagtcggggc
    11341 cgggcatcgg caggtccatc tcgggctggc ggaggtagcc ggctgcgacg gcggtgggga
    11401 tgtaggccat gagttcgctg acgacagcgg acgggggacg ggctgtgcgc ttcgcgaggt
    11461 ggcgcaggac gcgcagcatg gtagtggtgg acgcgttggt gacctggtgg ccggctgggt
    11521 gccagggctg tgccgctggt gtcggctggg ctggctggtc gccggggccg gctggggtgt
    11581 ggacgtcgtt ggtctgctga tgccaccagt gggcggcgtc tttctcgccc agggccaggt
    11641 ggtggaggta gaggcagtac gcggcggcgg cttggccgcc gcctgcggcg tactgccacc
    11701 agaagcgggc gccgtcgtcg gtgtcggtga gctgcagcac gcacgcgagg atcatggcgc
    11761 tgcggggctg gggcagttgc tcggtgacga actcggccac gtcgtcggcg agggtgtggg
    11821 tcacgagcgt ttcgcacagc gcccgcagat cttccgcggc agtggtgcag gtgctgtccg
    11881 cagcgtgcgc gtcgccggct gggagcggtt cgcgggaggt gatggtggtc ctggcaggcg
    11941 ggatgcggtc cgggggcacc gtgcggtcac ggaccagccg ggcgcgggag aggatttctt
    12001 cgatgcgttt catgcggtgt ccccttcggt ctcgggcggc gggcagatga cgctctccag
    12061 gaagtgggcg gcgtgacgct caccggagcg gaccgtggcc acggagacgc ctaggagagc
    12121 ggaaacgtcc tcggggcgga tcccgtacaa ctggcgcaac accaggacgt cgagctgctg
    12181 gtcgggcagg cggctcatga cggtgaaaag ctggaggctc tcccccagtt ggtccatgcg
    12241 ctcggcctcg gtggccaggt tccgcagcgc gatggtgtcg aaggcggccg ttccgaattc
    12301 gggccggcca tcgatatgcg gggtacgggc catgacggtg gcgcgcaggg tctgccaggc
    12361 gaaccgtcgg gtgtcggggc tcgcaagtgc ctcgttccag cggagccaga ggatgtcgaa
    12421 ggtgtcgcag acggctgtgt cgcgttggtc gtcatcgagg aagacctgcg cgtacaggcg
    12481 gtagtcgttc tccaccagtt cacggaacgc gcggtgatcg aggggcggcg tgtgagacgt
    12541 cgtcaaagac gacttctcgc tgcatcgttc gatccagtcg ctggacttct gggcctcgag
    12601 tgccgcttgg cgccacagcc ggtacagggg ccagccgggt atcttcagct ggatggacag
    12661 actgaggatg atctcccacc ggggatagag cccggttcct cgcagcagct cagagatctt
    12721 cgacttggcg agcgggaccc tgacgctgag atcgctgagg gtcagcccac tcttcaggta
    12781 ggtgtaccgc agtggttcaa gccaggcccg gtggacggtc cccaccccgt ccgcgatcgg
    12841 ccccagtttg cggccaggtc tcaggggtgc gggtctggcc ggggacggag gcggttcgct
    12901 gggagtcgtc acggggcgct gccctccttg tcgggcccgg cgtccgcgcg gtgccccgag
    12961 gtcggcccgg tctgggtacg ggcggcgcgg atgagctgct gcaccacgag tccgagaacg
    13021 ggcgccagcg cggcgatcgc ggcggtctgc cccatcgccg ccatcaccag gctccaggcg
    13081 aacaccgtcg ccatgatgat cagtatctgc ttcagtccca tcaacaactc ctcgatgccg
    13141 gccatatgcc ccacggccca tccggaagcc gtgaagcccc ccagaacgcg ggtgccgatg
    13201 ccgctcccct gggagcaacc agcttgaacc gtacgggagt tgttacgcca cgtgatcatg
    13261 gattcacgga acaatggcaa cagggagcgt cacagaccac gcccccggcg cgcctgcgca
    13321 ccgagacggc ccttgcgcta cgaggaagca caaccaccgc acctacgggt agaagttccc
    13381 ggatttcctt gcaatccccc ggcccagccc cgtcaatgga ggcatgacac ctccggtgtc
    13441 ggccttccat ccggaagggc tcgctcccgt gccgagattg atggggagca agcgtgaccg
    13501 ctctcgcctg gccgctgttg gaggccaggc gagagcggtg cggtccccac acgaggacga
    13561 cacgaccgta gcccagccca cggccccggc acacggtcgg cggtcccagg ccagcagggc
    13621 cccgaaccac gcgccggacc catcgtggtg cacgacgatg ctggccgggg tcagacgtgg
    13681 aacggtggct gaggccagcg gtagatgcgg cagggggccc accagtggag gccgccgaag
    13741 ctcagggtga gggattctgt ggcgagggca tccaggatgc tgtccgtcag ggcgtccggg
    13801 gaggccgggt gggcaggggc gtccgcggtg agttcggaga tcgcggcgtg gtactccggc
    13861 tcgtcgatga cgatgcgttg caggacgccg ctgcggtggt cgcggatctc caggaatccg
    13921 gggccgtggc ggtacgagca cttgccgagg aaaaaggtgc gggcccagtc ggctcgcagc
    13981 cgagcggcat ccccgcagcc gtcgatctca cgcggtgggt aaaggtggcc gagcgctgtc
    14041 gcggttgact cgtcgcccag gcgtagacgc aggcgccagt ccaccacgat cccgcgcgcg
    14101 gtcagctcct ggagtaggcg gagagtgcgg accaccgctt cgggtacgcc gattgatgac
    14161 aggtcgactg cttcgaccag ttcgatgcgg cgggcgcctg acgcgtagag ctcctcggcg
    14221 gtagacgcta cggcaccggt caccgacgcc gatccgagga acatccccgg cagccggcgg
    14281 acttcgtcct ggtagtcacg ccaggctcgt accgcgagtg gggtgggcgc gctgctcatc
    14341 tcatgtccct cgctgccggt gcctcggcgc ggcggaactc ctgggtgagg tccggggccg
    14401 acggttcgat gcggttcagt tcggtgttgg cggccagggg cgcgacatgg acgaaccggt
    14461 ccgcgtcttc gaagacgatt ccggcttcgc gccagtccgc caggatgcgt cgcacgtgtg
    14521 cctcggggac gggtgtgccg aggctggcgg tcaggcgccg tgcgagcgaa ccgacgctgc
    14581 gcgggttccc cagcagatgg aacgcggcca gctcgaccgg gtcgtcgatc gtacggaccg
    14641 tccagtcgaa gtgcggccgc ctgctggtca gcaccatcct gtcgccgaga tcgtggtgcg
    14701 tgaggcggca tgaggcgtgc acggcacgcc attcggccac ggcatccgcc aggcgttcga
    14761 caacgacgcc gtcgacgccc gcgtgcttag cctcgaagag ataggccagg tcgtgcagtt
    14821 cggactcggg caggtcgtag atgtgggcgt agtgggcagc cgggcgaagg tcggcgaagc
    14881 ccagctcggg ccggtcgaag tacgggctga accgctcgat ggcgatacgg gtggcggcct
    14941 ccggaggcgg gaggtggtgg agggccggca tctggcgtat gacggaggtg tagtcggctt
    15001 ccgtctcgcc aggaaagccg tagagatagt tccagacggg ccacacaccg gctgactgag
    15061 tgtcgcgcag atgccggacg ttctggcagc ccgtgacgcc cttcctcatc aggtgcagga
    15121 cccggctgct caggctctcg atccccggct ggacctggac gaggccggcc tcggcgatgg
    15181 tcttcaactg acggtggtga aggttcgact tgatctcgta gtggaagcgg tagtcgtacc
    15241 ccaggccagc gagttccggc agcagactgt ggatgtagcg catgtccagg atgttgtcga
    15301 cgaccaggat atcgaggacc tggtgtcggc gtgactggtg gacgatcgag ttcaggaagt
    15361 cgacgggttc cttgctccgg aactgcatcg acgagccgtt gaggccgcag aaggtgcagt
    15421 ggtgcttctc cccccaccag cacccacggg agccttcgag tacgagtttc ggttcgatgt
    15481 aggggcgtgc ggacgaccgc tcgatccgat ggaagtaggc gtcgaagtcg ggttcggcca
    15541 tccggtctgc cgaccggggg gcggccgaca tgccggtcac ccgaggctca cccgcttccg
    15601 tacgccagca cagtccgggt atctccgcca cgtcggcatg tccgcgcagc ccctcgagca
    15661 gcgccggaaa ggcatcctct gcctctccac gcacgacgtg atcgacaaag gggaagttcc
    15721 ggtgcagggc ttcgccttgc ggcccatcgc agttggctcc gccgaagacg gtcaccgtgt
    15781 cgggcgcgag cagcttgatc tgccgggcgg tggccagcgc ggcggtgttc tgctggaacg
    15841 tggtggtgaa gcctacgaca tcaggggagg cttcgacgat gcgggcagcc agctcggcga
    15901 cgaagcgggg ggccagatcg tgcaggcgca ggcttgcctt gcgcagttgg tcggtgactc
    15961 cggccgccat ctcctcgtgg aattcacggg tacgccagtc cggagcgtcg tagagggcgc
    16021 tggagaagac ccagtcgccg aatccctcga agtacgcgtg gtgggcgaag tactcgtagt
    16081 cgtcgacggt gagatccacc gtctgctccg cccagtcgta gaagtccacg ttggcgcaga
    16141 gggttatcac gtcgtcgaca tgcggccgta cgacagcgtg caggatgccg agggcgagcg
    16201 acggtgtgtc gagcgaggcc cacggcatat tgaccaacat cacgcgcacg cgtgcgctcc
    16261 tccctcacga gccggtggtc atttcccggt cacgggcgcg tcagccttcg ggggcatgat
    16321 gccgatcgtg gcgttgcctc gggactgagc cttggtgtgg gggttcgtgt gaatggtggt
    16381 cttcttcatc tgtcttcccc tgtcgtgcga tgcggccggg acgtgcggga gaccttaggc
    16441 tctgcccctt ccgcttttct tccgggtccc ggagtgagcg aggccaggag gcccgatggg
    16501 ggcagctcgc cgacgagccg ggagagggtg gtcacggcac cccgtgccgt ggcggctctc
    16561 tcgggatcat cggtggcctt cagagcctgg ccgagcaact ccacggtaga gagcagcacg
    16621 ttgtgcacgg gccgggtgtc aagtatgccg atcgcttcga tgagttgctc gatggcgcgg
    16681 tcgcctcggt tgtgggcgag gtccagggcg gctcgcacat agagcgcctc agccgtgccg
    16741 aatccaaggt ccatttcctc gagcagggcg acaccttcct cgacgaagct ctgggccgag
    16801 gggtcgtcca gctgaatcag cgtcagcccc agtgtgaggc tggtgaacgc cacatagggc
    16861 tggtcgttga ggtcctggaa cgtcgcacgc gccgcctgtg cgtaggtgcg ggcttcgtcg
    16921 agggcctcct ggtggcgcag gaccacggcc agataccgca tggccagggc ttgttcacgc
    16981 tggttgtgca cctcgcggcc cagcgtgagg gcttcgcgca gtgcctgggc cgacatgtcc
    17041 cactgagccc gctcgtagtg gatggtgccc agttcacgcg tcccccgtgc ttctgccacg
    17101 aggttggagg tggctcgggc tatgtcgagt gcgcgacgca cgcgttccag cgcccggtcg
    17161 tgttcgccca gcacccgcag ggccgccgcc tgggcgacca gcgcgtcggc gataacgacc
    17221 ttgtgtccgg cgtcttccag aacctcctcg gcgcgttcgg ccgagcgcag gctcgcggcc
    17281 gcgtccgtac ggatgaggta cagaccggcc agacgcatca gcatcacacc agcgccgacg
    17341 gtgtcaccct cctgtcggca ggcgtccaga gccagggtgt gggtggtctc ccagtcgtcg
    17401 tagcgatggc agagttcgag atggtccgtg atgctgtcgg cgagagccca ggcgagtgat
    17461 ccaaagcccc gcgcgctggc ctcgacgatg gctgacgtca gggcggggcg ttccgcctcg
    17521 aaccactccc gaggggatcg caggatccag tcgacgtcgc agggggcgac agggctggcg
    17581 tgtcccgagt ccgccgacag ctggggtgac cagccatgcg ggctcgttcc gtacagccga
    17641 tggccggctt ccgcggcgag atgtacccag aagctgagga ggcggccgaa cgccgcgcgg
    17701 cgctccggct cggggcactc gctctcggcg cgttctctcg cgtacaaccg gacgaggtcg
    17761 tggtatcggt accgggtgtg gcctccgatg gtgctgtcga cgatgtcgag gagctgggaa
    17821 ttgacgagct cctccacgat gtcctcagcc tcgtcgacgg tcgtgtcgag caggggggcc
    17881 aggacccagg cggcgaagtc gtcggcgttg accagaccga gcaggcagaa ggcctggcgt
    17941 tcgcgcaccc cgagactctg gtagctcacc gccagattgg cccggacttc gaggtctccg
    18001 gcgacgagga tgtcaagacg ccggcgctcg tcggtcaggc gccgggcgaa ccacgccaga
    18061 tcaccgcggg agtgctgggc gaagcgcgcg gccgcgatcc gtacggccag ggggagatgg
    18121 ccgcacagct gagtgatctc gagcgtggtg gcctggtcgt cgcggggcag gtcggaaccc
    18181 gcgatgcgct tgaagagctc cactgaatcg gacgagtcga agacctcaag gtgtacgtgg
    18241 tgggcggctt ccaggccgca caggcgcgtc ctgctggtga tgagcacggc gcagtccggg
    18301 gagctgggca gcaacgggcg tatctgcgcc tcctccgtgg cgtcgtcgag cacgatgagc
    18361 atgtgacggg tggcggagcg actgcggaac agccgggtgc actcgtcgag gctgtcggga
    18421 atgaccgggt cgtcgacgcc catggcacgc agaaacccct ggagagcgac cttcggttcc
    18481 acgggccggg cctgggagtc gcgcaacctg acatacagct ggccgtccgg gaagtccggg
    18541 ccgacgcgcc gggccgcgtg cacggcgagg gtggtctttc cgaccccgcc cttgccggcg
    18601 atcgccacca gggcgggcgc gtcttcgtgg gccgccctca ggaccgtaca gatctggtcg
    18661 acctcatcgc tccggccggt gaaatccgcg atggagggcg gcaattgagc gggtacggga
    18721 cgggcggggg tgggggcggg ggcgggcgga gtggcgtcgc tgtccgcgtc actcctggcg
    18781 agggtgacgc tctccgcgct ttcggtcgtt ccggtgtcga cgtggagggc ggggtccatg
    18841 accagaatcg cctggtgcag gcgctggagc tctgtccccg gttcgatgcc gagttcctcc
    18901 gccaggagcg tgcggccctc gtggtagacg gcgagcgctt cggctacgcg gccgcagcgg
    18961 tacagcacca gcatgaggtg gccgcgcaac tgctcgtgca gcggattggc ggtgaccagc
    19021 cctgccagct cgccgacgag ttccgtatgg cgccccaggg agagttcggc ctcgatcatc
    19081 tccagcaggg cgccgatccg acgctcctcc agggcgggtg cctcggcgcg ctgtagttcg
    19141 tcggtggtgt cggcgagcgg cacaccgcgc cacaggctga gcgcggcacg aagctcgcgg
    19201 gcggcctcgg cctgccgacc gctggcgcga gcggcacggg cggccgccac gcctcggtcg
    19261 aacatgagca gatcgacctg gtcctgttcc aggcacagcc ggtatccatg gccgtgacgc
    19321 acgatgcggt cctgccccag ggcgctgcgc agacccgaca cgtacttgtg tacctgggcc
    19381 accgccgtgg gcggggggca ctcaccccag agaacctcga ccagccggtc ggtgaggacg
    19441 atgtggtcac cgcggagcac gaaggccgcc aggagcgatc gtgccttgcg cccgttgagc
    19501 cggacggctt ggccatcacg ccgcacctcg atcggcccga gcacacggaa ctcacgcata
    19561 acgccccccg ttgatggtga atccgagccc ccgggcggaa tccgcccaga tcgttttcgc
    19621 cacgcgctgt gctgcccgca gcctagtaga gccttccgat cgtcctcaag acaccgaaac
    19681 aagcccaggt cagcgggatt cccacggccg ggtagcgcgt cggaagaatc cgggaagcgg
    19741 tcgctgcgac cgtatggccg tcagcaacgc agaagcggaa tgggaaccgc aggtcccggc
    19801 cgatgccacg acggcaagac cgcgcggtgg ccgccgcacc actggcactc aggtccatcc
    19861 gctcgccgcg atgaacggga acggcctggt caccgcccgg gcggggcgtg gacggcatga
    19921 ccgatgcgtg ggctgacagg ttcccctgtc ggctacagcg aaccgaagag accggcgata
    19981 ccggcgataa gggcgtgatc atggacggca tccgcaaggc tgaagaggcg ccgagagtgc
    20041 gcgacgtggc gaggcctgct ccccgagcag agctgaccgc acgaccggac gaacgcggac
    20101 cgctctcgta cggacagcag cggctgtggt tcctggatcg ctggctcgga agcaacgctg
    20161 tctacaacat acccgtgacg ctgcgcttca ccggcccgct cgacgccgac aggctgatcg
    20221 ccgcggtcac cctggtcgcc tccgggcatg acgcgctcta caccgtcttc gaggaggacc
    20281 agcacgggga gccacgacag cgcctcctgg acagccgcga accgcactgc gcgttcgtgg
    20341 acctcaccca gttgcccacc ggcgcgcgca ccgcacacgc ccgggaggct gtcgaagccg
    20401 atgcccgcac gcccttcgac ctggcgaagg accccatgct gcggatggct ctgtaccggc
    20461 tcgccgagga cgagtactgg cttcagctga ccttccacca catcgcctgt gacggctggt
    20521 cgttggacgt ctttgagcgt cagctgcgcg aggcgtacga aggtggagcg ggcggccagg
    20581 ccgccgagcc gctgcccgtc cagtacgccg actacgcgct gtggcagcgc gaggtgcttg
    20641 aaggtccgcg cgccgaaagg gcgttgcgcg cgtgggagga cgctctggca ggtgctccag
    20701 acctcctgga cctcggcctg gaccggccgc gcccggcgga gctgacgtat cggggcgaga
    20761 ccaccgactt cccgctcgac gacgtgtcgt tgggcaacct ggaggccttc gcggccgccg
    20821 agaacgtcag cctctacacg gtgctgctcg cggcgttcca ggttctggcc gcccgccact
    20881 cgggcagcga tgacatcgtc atcggatcgc cgaccgcagg gcgcgaccag gcccagctca
    20941 acgacctcgt gggcttcttc gtcgacactc tggtcctgcg cacggacctc tccgacgccc
    21001 cgagcttccg cgagctggtg cgacgcacgc atcgctcact actgaacgcc ctctcacgca
    21061 gcaaggtccc cttcgacctc gccgtgaaac aactgcaccc cgagcgctca ctgagccaca
    21121 acccggtggt ccagacgctg ttcgcgttcc acgaagagga gttgtcgacg tccttcgggg
    21181 agggcgtggc cgtcgagcgt tccatgatcc ccacgggaac ggccaagttc gacctcacat
    21241 ggtcgctcta ccggcgcccc gacggcctgc tcctccaagt cgagtacgcg accgaccttt
    21301 tcgacgccgc cacggtccgg agcctggtcg accactggcg ggtgctgctc ggcgagattc
    21361 tcgccgagcc cgacgcgcct gtcggtcggc tgaggctgat ggacgcgaca gagcgctccc
    21421 tggttgacgc gtgggcgggg cggggcggga gcttcccggt ctcctcgatt catgaggcgg
    21481 tggtgcgtcg tgctgtggag gctccggatg aggtcgcggt ggtgtgcggc ggagattcgc
    21541 tgacctatgc ggagttggtg gtgcgtgctg ggcgggttgc cgagtatctg aaggggcggg
    21601 gggttggtgt tgagactccg gtgggcgtgt gtgtggagcg ctcgctggag accgtggtgg
    21661 caactctcgg ggtgctgctg gcggggggtg tgtacgtacc gctggacacc gccttcccgg
    21721 ctgatcgcat gcggttcatg ttggaggacg tcgacgctgg cctcgtactg acgcaggggt
    21781 cgacggttgc gttggtgccg gacgggccgt gggaagtcgt cgacctcgac agtgatggtc
    21841 atctgtgggc ggaaggcctg acgctggagc gggtcgcgaa cgaggtcgcg gtggaggtca
    21901 gcgctgatca cgcgtgctac gtgatcttca catcagggtc caccggccgc cccaagggca
    21961 ccaccgtggc gcatggcaac gtcacccggc tgtttgaggc ggtccgtgcg cggctcccct
    22021 tcggcaaggg tgatgtgtgg tcgctgttcc acagcttcgc cttcgacgtc tccgtcatgg
    22081 agatgtgggg cgccctcacg agcggcgggc gccttgtcgt ggtcccctac atcaccagcc
    22141 gcgatgccga tgcgttctac gccctggtgc gcgacgagcg ggtcaccatg ctcagccaga
    22201 cgccgtcggc gttccgccag ttcgagcggg ccgacgacgc tacggcagga agcgaactcg
    22261 ccttgcgcgc ggtgttgttc gcgggcgagg cgttggatcg ttcgtcggtg cggcgctggg
    22321 gtgagcggca cggctaccgc gagccggtgc tggtgaacat gtacggcatc acggagacga
    22381 ccgtgcacgt cacctacgcc gaagtcaccg aggaacagct ggacggggca ttcaccctga
    22441 tcggtgaggc gctaccggac ctgcgggtat acgtgctgga ccccttcggt gatccgaccc
    22501 cggtcggggt ggtcggagag ctgtatgtcg ggggtcccgg ggtgacccgc gggtatatcg
    22561 ggcggccgga gctcaccgcg gagcggtttg tgccggatca tctgggcggt gagcccgggg
    22621 cgcggctgta ccgcagcggg gacctggcgc ggtggagggc cgacggcggc ctggagtacc
    22681 tgggccgggg tgacagccag gtcaaggtcc gcgggttccg gatcgaactg ggcgagatcg
    22741 aggccgcact gagccgacag cccggcatac gccaagccgt cgtcatcgtc cgcgacgacc
    22801 tcggagaaga ccaagccgac ctggtcgcct acctcgtccc cgacgacgac gccacaccct
    22861 ccaccagcgg gctacgggac gcgctcgccg acggcctgcc cgcctacatg atcccccgca
    22921 acttcgtcct cctggacgag ctgccactga ccccgcaggg caagctcgac cgccgggccc
    22981 tgcccgcacc caccggcgaa cggcctgacc tggaagtggt gttcgagtcc gcccggccgg
    23041 gtgtggagga acggttggcc gggatctgga gccaggtcct gggcgtggac cggatcggcc
    23101 gccacgacaa cttcttcgac ctcggcggcg actccatccg cagcatccaa gtcctcggac
    23161 aggcccgcgc cctggggatg gccttcgagc ttcaggacct cttccggacg cccaccctgg
    23221 caggcctggc cgaggccgcc gatgccagcg gcgatctcgc cgtgccgggt cggcaacgcg
    23281 agccgttctc catggtgtcg gccgaggaca gggcacggtt gcccgagggc ctggaggacg
    23341 cgtatcccat ggccgagctc caagtcggca tgatctacga gatggagctg gaccgcgacc
    23401 gcaagccgta ccacaacgtg gatagtatgc gggtcagcgg ccagttcgat gaggccgcct
    23461 tcaagcgggc actcgcgctt gtcgtgggtc gtcaccccat cctgcggacc gcactggaac
    23521 tcagcgccta cagcgtgccc ctccaactgg tccacgccga agcggagatg ccctgcttcg
    23581 tcgccgacgt acgccacctg aacgaagcgg cgcaggaggc cgcgatagcg gagtacgtac
    23641 tcgcgcaacg tcagcaaacc ttcgaccacg cgcgtccgcc gctgctccgg gtcggcatcc
    23701 atgatctcac cgacgacacc ttccagtgga cggtgaccga gcaccacgcc attttcgacg
    23761 gctggagcct gcactccacc cttgccgaga tatcgggtct gtaccagcgg atgctagcgg
    23821 gcgaatccgt tgaagcggag ccgtcgcccg cgtccgccta ccgtgatttc atcgcggccg
    23881 agcaggctgt gctgcactcc acggagagcg agaggttctg gctggagcgc gtcgaggatc
    23941 ggcctgaggg caagctcccg cgctggcccg ccgagtacga cgcccggctc actcctgccg
    24001 tgggcgagaa cgagtggcgc gcgtccaacg aggccgagaa acacggctcg atcgagacac
    24061 tgctgccgac agagctgtgc gaggacttgc tggcgttcgc caagaagcgc ggtgtcccgc
    24121 tcaagtcggt gctgctggcg gcgcacctac gggtgatgag cctggtcacc ggcagtacgg
    24181 acgtcctggc gggggtgtct tccaacggtc gcctggagga ggtcggcagc accgaggtgc
    24241 gggggttgtt cctgaacacc ctgccgttcc gcttcaagct ccctgagggc agctggtcgg
    24301 acctggtgcg ggcggtgttt gagaccgagc aggaaatcct cccgcatcgg cgctacccgc
    24361 tcggcgtgct ccagcgcaag ctcggcgtcg gctctttcct ggagacccag ttcgtctaca
    24421 accatttcca catcctgacc gacgagttcg gcaagggtcg gctggaaatc atggacggca
    24481 agatcgacag cttcagcacc atgcgttccg agcccaccaa cttcccgctc agcgtcggtg
    24541 tcatccgcaa cccgtactcc gttcgtctcc tgttgtgcct cgactaccac ctcggtgaac
    24601 tcgtcgagga ccaggtggcg ttggtgcgtg attactacgt gcgggtgctg gaggcgatgg
    24661 tcgctgatcc ggacgcctct tacgggcagg tacgggtgct cggcgacgat gagtcttccc
    24721 ggctcgggct gtgggcgggc gagggtgctc ggttccccgt gtcgtcgctg catgaggccg
    24781 tggtgcgtcg tgctgtggag gctccggatg aggtcgcggt ggtgtgcggc ggagattcgc
    24841 tgacgtacgc ggagttggtg gtgcgtgctg ggcgggttgc cgagtatctg aaggggcggg
    24901 gggttggtgt tgagactccg gtgggcgtgt gcgtggagcg ctcgttggag accgtggtgg
    24961 caacgcttgg ggtgctgctg gcggggggtg tgtacgtacc gctggacacc gccttcccgg
    25021 ctgatcgcat gcggttcatg ttgcaggacg tcgacgctgg cctcgtactg acgcaggg
//
