LOCUS       NZ_WHOM01000035        20774 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Streptomyces apocyni strain TRM 66233 451, whole genome shotgun
            sequence.
ACCESSION   NZ_WHOM01000035
VERSION     NZ_WHOM01000035.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces apocyni
  ORGANISM  Streptomyces apocyni
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 152434)
  AUTHORS   Liu,W.
  TITLE     Streptomyces poacynumensis sp. nov., a endogenous actinomycete
            isolated from Poacynum hendersonii
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 152434)
  AUTHORS   Liu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2019) Key Laboratory of Protection and Utilization
            of Biological Resources in Tarim Basin of Xinjiang Production &
            Construction Corps, Tarim University, Xingfu Road, Alar, Xinjiang
            843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABySS v. 2.2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009739465.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 17:09:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,397
            CDSs (total)                      :: 6,319
            Genes (coding)                    :: 6,205
            CDSs (with protein)               :: 6,205
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 34 of 114
            Pseudo Genes (incomplete)         :: 100 of 114
            Pseudo Genes (internal stop)      :: 6 of 114
            Pseudo Genes (multiple problems)  :: 23 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:56:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 101085
            Orig. end                         :: 121859
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHOM01000035.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20774
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="1"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20774
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20774
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10774](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10774
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            598..1563
                     /locus_tag="GCN81_RS03490"
     CDS             598..1563
                     /EC_number="2.8.1.8"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0016992 - lipoate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009249 - protein lipoylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018545494.1"
                     /locus_tag="GCN81_RS03490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lipoyl synthase"
                     /protein_id="WP_156721943.1"
                     /sec_met_domain="PF04055 (E-value: 9.9e-14, bitscore: 45.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAVAPDGRKMLRLEVRNSQTPIERKPEWIKTRAKMGPEYTQMQK
                     LVKSEGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPEPLDRDEP
                     RRVGESVVTMDLNYATITGVARDDLEDGGAWLYAETVRQIHAMTAERSDGYTKVELLIP
                     DFNADPDQLAEVFSSRPEVLGHNVETVPRIFKRIRPGFRYERSLKVITEAREAGLVTKS
                     NLILGMGETREEVSEALRQLHEAGTELITITQYLRPTPRHHPVERWVKPAEFVELKEEA
                     EQIGFSGVMSGPLVRSSYRAGRLYQMAIEKRGAYVASQAV"
     misc_feature    complement(1701..1716)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.62"
                     /tool="antismash"
     misc_feature    1712..1727
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(1712..1729)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     gene            1897..2100
                     /locus_tag="GCN81_RS03495"
     CDS             1897..2100
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478404.1"
                     /locus_tag="GCN81_RS03495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156721944.1"
                     /transl_table=11
                     /translation="MQAAPVRATAIPSVTDALRVVESLLMSRGHRTARRNAWASVVEDR
                     RRAKDRVEAQRVLEAVSSARTS"
     gene            2131..2832
                     /locus_tag="GCN81_RS03500"
     CDS             2131..2832
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326564.1"
                     /locus_tag="GCN81_RS03500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4191 domain-containing protein"
                     /protein_id="WP_156721945.1"
                     /transl_table=11
                     /translation="MARKDNAASTANPGRLKQIALTYKMTRKADPKIGLVIGAVGIVTF
                     GALLGIGFWIGHPVYLGILGFLLAFLAMAIIFGRRAERAAFSQMEGQPGAAAAVLDNIG
                     RGWTTTPAVGMNRSQDVVHRAVGKAGIVLIGEGNPNRVKGLLAAEKKKMARILTDVPVH
                     VFIVGTDEGQVPLKKLRTRMLKLPRTLTGPQVTATNDRLRAMGDLLSNMPLPKGPMPKG
                     MKMPRGGPQGR"
     gene            complement(2956..3423)
                     /locus_tag="GCN81_RS03505"
     CDS             complement(2956..3423)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969589.1"
                     /locus_tag="GCN81_RS03505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RDD family protein"
                     /protein_id="WP_156721946.1"
                     /transl_table=11
                     /translation="MDNRQAIGSWLSGPRQAAEDMGADFGYRGEQLGLPEHGPGAIAPL
                     GRRFGAIAVDWGLCMLIAYGLFARGDSQAMGNWALGLFLVLHVLTVGTIGSTPGKRLLG
                     LRVVSEDGGRLGFVRVLVRSVLLCLGLPALIWDRDGRGLHDRVGRAVQVRI"
     misc_feature    complement(3509..3526)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.63"
                     /tool="antismash"
     gene            3648..5057
                     /gene="glnA"
                     /locus_tag="GCN81_RS03510"
     CDS             3648..5057
                     /EC_number="6.3.1.2"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glnA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976617.1"
                     /locus_tag="GCN81_RS03510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="WP_156721947.1"
                     /transl_table=11
                     /translation="MFQNADDAKKFIADEDVKFVDVRFCDLPGVMQHFTVPAAAFDPAE
                     QLMFDGSSIRGFQAIHESDMALVPDLTTARLDPFRRDKTLNVNFFIHDPVTGEAYSRDP
                     RNIAKKAEAYLASTGIADTAYFGPEAEFYVFDSVRFNTAANESFYHIDSEAGAWNTGSE
                     ENNRGYKVRYKGGYFPAPPVDHFADLRAEISLELDKNGLQVERQHHEVGTAGQAEINYK
                     FNTLLAAADDLMLFKYIVKNVAWRNGKTATFMPKPIFGDNGSGMHVHQSLWQGGIPLFY
                     DEQGYAGLSDTARYYIGGILKHAPSLLAFTNPTVNSYHRLVPGFEAPVNMVYSQRNRSA
                     AMRIPITGSNPKAKRVEFRAPDPSSNPYLAFSALLLAGLDGVKNKIEPAEPIDKDLYEL
                     APEEHANVQQVPTSLPAVLDALEEDNEYLQAGGVFTSDLIETWIDYKRTNEIAPIQLRP
                     HPHEFELYFDL"
     gene            complement(5864..6235)
                     /locus_tag="GCN81_RS03515"
     CDS             complement(5864..6235)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483315.1"
                     /locus_tag="GCN81_RS03515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_156721948.1"
                     /transl_table=11
                     /translation="MPELIHALILWASLIFGLRGGGGQRPRPTVRPAPARASLHLVPVP
                     VPVAARRAREWLPAPRSPYGLDTPLDGEETALVRPYLTEHEERQERARQRRRCLALVLA
                     ADFGVDLDRHLVGARGVAS"
     gene            6410..6676
                     /locus_tag="GCN81_RS03520"
     CDS             6410..6676
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991199.1"
                     /locus_tag="GCN81_RS03520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_231626333.1"
                     /transl_table=11
                     /translation="MTDKINPGAAAYHYEQLAKILEGKIRSGELPAGTRLPGEMVLSQE
                     YGVGSNTVRRALEILRDRDLVVTVRARGSFVAEQPPAAAPEGD"
     gene            complement(6950..9757)
                     /locus_tag="GCN81_RS32670"
     CDS             complement(6950..9757)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024816.5"
                     /locus_tag="GCN81_RS32670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_156721950.1"
                     /transl_table=11
                     /translation="MDPGLTNHISGGVFLSTVIQGGIVNVTLPPEITPALSGLPAPASA
                     FTGREADVERLLQGLAPGAGRRPAAPVTAVAGLGGVGKTELVVQAASRALARPGWFPGG
                     VLFVDLFGYDRERRVPPDLALDGFLRALGLPAVHIPTQLQDRVRLYRSVLAAFAEQGRR
                     VLVVIDNASSAGQAGPLLPADGTTAALVTSRDALDLDARRHTVRALDQAASVALLDQAI
                     RAGRDIGDISDTGDTGDIDDTRIADSPADADAIAGLCAGLPLALRIVAALLADFPARPL
                     SSVREALESTDDRLDLLGSRDTAVRAAFDLSYQRLDPDHARTFRLLSLNPGPDLSTEAA
                     ACLVDQSRLRTELLLQDLARAHLIETGPLWGRWQLHDLVRLHADEHGRACAATDGREDA
                     RERLYAYYLTGARAADRYFEVPPPPVQSTDRFPERGAALSWLGGEQRNLVAVVLAAAAA
                     AAAADTPRTAAALTLHITHYLYERRDFASMLAVAETTLPVCAGLRDPTVAARTLNIQGT
                     ALRGLGRYEEAADAHRQAAAEHRELGNDSLEAGALSNLGVVLQHLGRSAEAIDVHRRAL
                     TLLETAGPLRDEAVVRNNLGTALQAQRHFHQAADEHRRAAALLSGLGDPFGEADSLNNL
                     GATLCGLGSHREAVDAFRKALAAGQGREDPDAEATVLYNLGEALRAVGGFGEAADHLRR
                     AVGIQRERGDRRGEADALTLLGTVLRDAERPSEAADAFRLAVAVLAALGDRTEQAGTLL
                     DLGGVLHDASRSEEAVEAFTRSATIFRELGDRRNEASADYNTGHALQALGRLPEASDAY
                     SRAATTFHELGDPQEASAVNALADTLLKAGLVERALTLRQQALAICEKHGDRLWAASVL
                     AKLALDLRQAQRYEEALQVHDLAISGFWQTGAPHDSYLATVARDETARLYEESLARRGR
                     FWRRK"
     misc_feature    complement(8777..8779)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9984..9999)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.54"
                     /tool="antismash"
     gene            10001..10774
                     /locus_tag="GCN81_RS03530"
     CDS             10001..10774
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889609.1"
                     /locus_tag="GCN81_RS03530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_156721951.1"
                     /sec_met_domain="CDPS (E-value: 2e-86, bitscore: 282.3,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQATLAPAETFHLTPYTPHCRVIAEEGDHAVIGVSSGNSFFSAQ
                     RLHGLARWGMENFHQVDFVYTDLHVADMFEALGYPPDDARRKAVKNLRGVRAKVTNAVQ
                     EADPSGDRVRARPMSALTLAPAYQRIHTRIQGLLETDQEFRAACEQLTAIFLDGKLAPG
                     EAASARQTQVCLDYVCAEAPLFLDTPAILDVPSSVNCYHQALPLADVLYARGPGLRASR
                     NQGHGILVPAEGEQRDDRGDGLGDRTDRGDQGVRL"
     gene            10771..11973
                     /locus_tag="GCN81_RS03535"
     CDS             10771..11973
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889608.1"
                     /locus_tag="GCN81_RS03535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_156721952.1"
                     /sec_met_domain="p450 (E-value: 6.5e-16, bitscore: 51.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPPRTTLPAFPFSWDGTRLPDDVEALRAEPVKRVRTIAGDEA
                     WLVSSYALSKQVLEDERFSLKDTSAPGAPRQYALTIPPEVVNNMGNITGAGLRRAVMKA
                     VNPKAPGLQEWLVKSAHGLVDQLERYGAPVDLRGDFADPYSAGMHCHILGTPQGDASRL
                     MRSLDVAFMNSPRSVEAARLNWDRDIAYMVARLDDPDLVPGGLMAELAALRGDPDYDHL
                     TDEMLATVGVTLFGAGVISTAGFLTMAIVSLLTREDVREQLTADPSRVAGAMDELLRIN
                     LSIGDGLPRIALADVQLGDVTVREGELVLVLVEGANYDAEQFPEPNVFDPGRENAHTHL
                     SFGGGAHYCPATALGKKHAEIALQALVERLPGLRLAVPVEQLVWRTNFMKRLPERLPVA
                     W"
     gene            complement(11933..12796)
                     /locus_tag="GCN81_RS03540"
     CDS             complement(11933..12796)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031614.1"
                     /locus_tag="GCN81_RS03540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_231626334.1"
                     /transl_table=11
                     /translation="MSYAYDEGPTVIDTLDFAITPGRALALLGRNGSGKTTLMRLLSGG
                     LRPASGTLLLDGTPVTYDRKGLTRLRTTVQLVVQDPDDQLFAASVEQDVSFGPMNLGLS
                     DAEVRTRIDEALTALDITHLRDRPTHLLSYGQRKRTAIAGAVAMRPRVLILDEPTAGLD
                     PDGQERLLATLARLRASGTTVVMATHDVDLALHWADDAALLIPSGVHTGPVADALARQD
                     LIHQAGLRTPWGIAAAQLLSTHGLLPTGSTGPRTPDQLAAWTGGGQGTGTATPTRRPEA
                     AQEGAS"
     gene            complement(12907..13668)
                     /gene="cbiQ"
                     /locus_tag="GCN81_RS03545"
     CDS             complement(12907..13668)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0032778 - P-type cobalt transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006824 - cobalt ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cbiQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030565.1"
                     /locus_tag="GCN81_RS03545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cobalt ECF transporter T component CbiQ"
                     /protein_id="WP_156721954.1"
                     /transl_table=11
                     /translation="MLPIDAAAHSSRWRRRHPVDKAVLGLGLTVLAISLPPWPGAALVI
                     VTALTVLLGPAGVPPRRLWRAYRIPLGFCVSGALTLLVQVGAPEGFVTLDPEGPARAAG
                     LLLRTSAASLGVLLFAFTTPMSDLLPRLVKAGVPAAVVDVALVTYRMSFLLLDSMTRIR
                     QAQAARLGHTTRAATWRSLAGLGATAFVRAFDRASRLQAGLAGRGYDGTLRVLVPEARV
                     SPRFVAAALTLLAAVAAVALTLHHVLERPLG"
     gene            complement(13684..14067)
                     /locus_tag="GCN81_RS03550"
     CDS             complement(13684..14067)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015087 - cobalt ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006824 - cobalt ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321122.1"
                     /locus_tag="GCN81_RS03550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="energy-coupling factor ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_156721989.1"
                     /transl_table=11
                     /translation="MSKNAKINTLLLLVVAALAVLPLALGLGDHKEEPFAGADGEAEGA
                     ITEIDPGYEPWFTPLYEPPSGEVESALFALQAAIGAGVLAYYFGVHRGRRQGEARARAA
                     YEKNAENAENAENAETAASPSGD"
     gene            complement(14070..14804)
                     /locus_tag="GCN81_RS03555"
     CDS             complement(14070..14804)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_process="GO:0000041 - transition metal ion transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006136286.1"
                     /locus_tag="GCN81_RS03555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="energy-coupling factor ABC transporter permease"
                     /protein_id="WP_156721955.1"
                     /transl_table=11
                     /translation="MHIAEGFLPPVHAVAWSAAAAPFVIHGVRALTREVKSNPESTLLL
                     GASGAFTFVLSALKIPSVTGSCSHPTGTGLGAILFRPPIMAVLGTITLLFQALLLAHGG
                     LTTLGANVFSMAIVGPWAGYGVYRLLRRFDVPLMGAVFGGAFVADLSTYCVTSVQLALA
                     FTDPSSGFLGALGKFGSIFAVTQIPLAISEGLLTVLVMRLLVRSSKGELTRLGVLLTRK
                     QSQAAQAAKGAQAAEGTEVESR"
     regulatory      complement(14834..15020)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(15089..16735)
                     /locus_tag="GCN81_RS03560"
     CDS             complement(15089..16735)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644094.1"
                     /locus_tag="GCN81_RS03560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_156721956.1"
                     /transl_table=11
                     /translation="MLTRWRNHVWGPLDKAIAAVVCLALLVGLGLLVVTLLPDECGEGL
                     EEVGGECVGVTATDSLKGDPEIQSLITAIAEENASVKKAWETPEKGSPRIPYARIALMM
                     PFTSDDTSTMTAEEMRRALAGAYTAQLEANAATGPHYQLLLANDGKDLDKWRPAVDRLI
                     GMTDDESPLVGVLGMPSSTPETLKAVEALGEHRIPSVGPILTGTTMKDSYLFKTSPSNA
                     LLVDALVKYLAKEPGDRGFLVADNRQKDAYSLDLRDQFEDRFSDTYGLDKNRAYYLGIT
                     GEDAGIPRRFSSVAQKVCVTGSDTVFFAGRDRDLPYLIRHLVKEPACDNSKPLRILKVG
                     IGLDTEHSKPELTQQMRDANITLVNAASVDPAWWEDKTHKERPEGLAHFLEQFEEVEKK
                     HELGERPLDDGYSIMYRDSFTVLSEAFDQAYNEINAIDPDADTDTGTGTDTGTAPPVMP
                     TTDDIYQTIINMGILDTEDGASCVSCVLGASGTFGFDDARETEQWPVCKPVPVMEYPPP
                     PQPKGKADGKGGAKAPKLLRTYEHVFQGGCP"
     gene            complement(16776..18896)
                     /locus_tag="GCN81_RS03565"
     CDS             complement(16776..18896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644095.1"
                     /locus_tag="GCN81_RS03565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_156721957.1"
                     /transl_table=11
                     /translation="MRSQLYARDPLLHALVPRLVGLAPAKRELVRQEHPGDQPVVLLTG
                     RHGMGKTAVLAALDAAYRGRVPLGRVDVSEADPARHTGFAASNASTVVEVLVQLACDLA
                     PTLGRPGRPVFPRLLPGLFAISSWHRGGDHERRLARDRIDRLLTACDLREDSGAGPEGG
                     GVQDWTYEISEGLADAGGQQDLEAVATAVIARYFHQHTKARPGRTAREWYQGHVPGSAD
                     GEAALVRLCLRFHQGGAYRHAVERLLVAAFTEDVTGAYGRWQRANRTPRPLILLDNVHT
                     EAGEELLDLILQQRAAAPDTHDPLVVIATRLGDTTTSRYPDATRRRLTEVLATSGWSRT
                     APASPSAGLLVIPLAPLDLDDVLLMLDRADAPLHRHLPAALHALTRGHPEGSALLGAAV
                     VRTAGERTVRPEELLDLPAHDGRPVTELLLERLIPHPQHRDHLILLSPAPDRAAADALA
                     ARSTGIGGDPLPAAEAARYLEEEHWTAVPEGEAADDNTPDTPGGSPRFVPDPFLRDLLI
                     HQARGGADAGRRWDGTHIVLREHYATLGPAHVADVLRHTLAGFGAEPVVARLTQDFGRQ
                     DVDAADWLRALRHISTAPHPPLAHWRDDRAEIARGAHDHRHPDTGRTDGPGGTGGPGDT
                     GTIARSVNRLLHAVWYLREPFAEPLDDLCEGVGTELRFLSVRHPTGHAVLNRAAQTWPV
                     ALRHRWPRPIEP"
     misc_feature    complement(18036..18038)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18942..19910)
                     /locus_tag="GCN81_RS03570"
     CDS             complement(18942..19910)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GCN81_RS03570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_156721958.1"
                     /transl_table=11
                     /translation="MSAAAPSFPDPDSESFDRYRSRLLLWVWDRVMRDPDLPVPCAEFG
                     IWQAIPQSTVWSLVDRLSEQLLISAQGSRQHAPVVTLLPAGVAEARLLQARRADPVRRG
                     RHATSAVLRWIYASSDRQPLRIEAFFDSGEVFFLGEALSRSEVARALSYLADSRLITCT
                     GPEFQGGVGSEVALTALGTDAVLSEGEVGGIGEFVARQRQRAQQTHIEAATVNYAQGDF
                     HHTVSVQTALSPAELGSLIQQLAPVLALDDEARAALLASAAALARTGDPGGDPGGGAPD
                     PDRQRGLMERVRSLLGGTPDTVGRQVALDAIGQALGRLLGG"
     misc_feature    complement(19179..19181)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(20020..20029)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     misc_feature    20074..20087
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.58"
                     /tool="antismash"
     misc_feature    20581..20590
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 gctgggcgac ccggtggagc agcgtcttgg cggcctcgcg ctggacttcg acccgcggct
       61 cacggacgac gagttcgact cccggatgaa cggtcctgag tacgccccgt ccaacgccgg
      121 gcagcgccgc gaggaccgca agctgggcgc gatcggcatc cgggtcgcca agggcgtcac
      181 gatgcatggc ttcgcgctga acgtgaaccc ggacaacacc tggttcgacc ggatcgtgcc
      241 gtgtggcatc cgggacgcgg gggtcgcctc gctcgcgggt gagctcggcc ggaacgtcac
      301 gatcgaggag gtggcaccgg tgctcgagcg gcacctgagg gacgtactga cccacgccga
      361 cctcaagccg cgcgtgatcg agcgcgaggc cgagagccag gtcgagcgcg agaccgggcg
      421 cgagaccggg cgcgagaccg ggcgcgaggc cgtggaggcg actgtgtagg ggcctggact
      481 gccgtagcgc cctggggaat gcgaccctag ggccagaggt tggcaggacg tagggccgta
      541 caaataacgg gcgtaccctg gtgtgcgccg aagaatcgaa gttgtaggga gccggacgtg
      601 tccgctgtcg cacccgacgg acgcaagatg ctgcgtctgg aggtccggaa cagccagacc
      661 cccatcgagc gcaagcccga gtggatcaag acccgggcga agatgggccc cgagtacacg
      721 cagatgcaga aactcgtcaa gagcgagggt ctgcacaccg tgtgccagga ggcgggctgt
      781 cccaacatct acgaatgctg ggaggaccgc gaggcgacct tcctgatcgg cggcgaccag
      841 tgcacccggc gctgcgactt ctgccagatc gacaccggca agcccgagcc cctggaccgg
      901 gacgagccgc gccgcgtcgg tgagtccgtg gtcaccatgg acctgaacta cgccacgatc
      961 accggcgtcg cgcgcgacga cctggaggac ggcggcgcct ggctgtacgc cgagaccgtg
     1021 cgccagatcc acgcgatgac ggcggagcgc tccgatggct acaccaaggt cgagctcctc
     1081 atccccgact tcaacgccga tcctgaccag ctggccgagg tcttctcgtc ccgccccgag
     1141 gtcctcgggc acaacgtcga gacggtgccg cggatcttca agcgcatccg ccccggcttc
     1201 cggtacgagc gctcgctgaa ggtgatcacc gaggcccgcg aggcgggtct ggtcaccaag
     1261 tcgaacctga tcctgggcat gggcgagacc cgtgaggagg tcagcgaggc gctgcgccag
     1321 ctgcacgagg cgggcaccga gctgatcacc atcacccagt acctgcgccc gacacctcgg
     1381 caccaccccg tggagcgctg ggtcaagccc gcggagttcg tggagctgaa ggaggaggcc
     1441 gagcagatcg gcttctccgg tgtgatgtcg ggtccgctgg tccgttcctc gtaccgcgcg
     1501 gggcggctct accagatggc gatcgagaag cgcggcgcgt atgtcgcctc gcaggctgtg
     1561 tgaattcacg cacaagcgac tactggccag taacggccga gatggcgcgg cccgtacgct
     1621 ccccgcaggt cggggcggtg tacgggccgc gtcaggtttg cccgccctgt cccggcaccg
     1681 cgccaaggct tcattgcggt ttgaccggtc ggtcacgtcc tggtaacacc aatcagtgac
     1741 gctgtactca cgccgagtgc tacgccccca ccgctcggct ctcgcgccac cgctgatacc
     1801 gcgtcgcctg acaccgcacc gtcgctgtta ccgctcgccc gtactcccgc tacacccgct
     1861 cacccgtgct tccgccacca agaggggacc cccgccatgc aggccgcgcc cgtacgcgcc
     1921 accgccatac cgtccgtcac cgacgccctg cgcgtcgtcg agtcgctgct gatgagccgc
     1981 ggccaccgca ccgcccgccg caacgcctgg gcctctgtgg tcgaggaccg gcgccgggcg
     2041 aaggaccggg tggaggctca gcgggtcctc gaggccgtta gctcggcccg cacgtcgtag
     2101 ccggctcgcc ggggacgtaa acttcacgac atggcgagga aggacaacgc agcgagtact
     2161 gcgaacccag ggcggctcaa gcagattgcc ctcacgtaca agatgacccg caaggccgac
     2221 cccaagatcg gtcttgtgat cggcgctgtg ggaatcgtca ccttcggggc cctcctcgga
     2281 atcggcttct ggatcggaca cccggtctac ctcggcattc tcggcttcct gctcgccttc
     2341 ctggcgatgg cgatcatttt cggacgccgg gccgagcgag cggcgttcag ccagatggag
     2401 ggccagccgg gtgcggctgc cgccgtgctg gacaacatcg ggcgcggctg gacaacgact
     2461 ccggcggtgg gcatgaaccg cagccaggac gtggtgcacc gcgcggtggg caaggcgggc
     2521 atcgtcctga tcggcgaggg caacccgaac cgtgtgaagg gcctgctggc cgccgagaag
     2581 aagaagatgg cgcgcatcct cacggatgtg ccggtccatg tcttcatcgt cggcaccgac
     2641 gagggtcagg tccccctgaa gaagctccgc acgcggatgc tgaagctccc gcgcacgctc
     2701 accgggccgc aggtcaccgc gaccaacgac cggctgcggg caatgggtga cctgctcagc
     2761 aacatgccgc tgccgaaggg cccgatgccg aaggggatga agatgccgcg cggtggcccg
     2821 cagggccgct gaacccgttc ttcccaacgc cggaggggcg cccggntggg ttccgggcgc
     2881 ccctccggca tgcgcggcgc gcgatccgta gcgatacggg agccgtactg gcgtactgcc
     2941 gtactggcgc gcggcctaga tccgcacctg aaccgcgcga cccacgcgat cgtgcagccc
     3001 acgtccgtcc cggtcccaga tcagcgccgg gaggcccagg cacagcagca cgctgcggac
     3061 gagcacccgt acgaagccga gtcgcccgcc gtcctcgctg accacacgca gaccgagaag
     3121 ccgcttgccg ggcgtcgaac cgatggtgcc cacggtgagt acatgcagca cgaggaacag
     3181 cccgagcgcc cagttgccca tggcctggct gtcaccccgc gcgaagaggc cgtaggcgat
     3241 gagcatgcac aggccccagt cgacggcgat cgcgccgaag cggcggccga gcggcgcgat
     3301 cgccccgggc ccgtgctcgg gcagcccgag ctgctcgccc cggtaaccga agtcggcacc
     3361 catgtcctcg gccgcctgcc gggggccgga cagccacgat ccgattgctt gcctgttatc
     3421 cacccgtaca cggtactgcg ccctgctgta gccccccggc cccgggccct gcctgacctc
     3481 tctgagatgc cgctcacccc tgacccggtt aacttcaacg aaacaaatgg gtcatccttg
     3541 agaaacggcc cgtccctaag gtcaggtcca gcgtgtgcca ccgcactggc cgcaccaaga
     3601 gctacacatc cccggctcca ccccggaccg ggagtaggag gagctggatg ttccagaacg
     3661 ccgacgacgc caagaagttc atcgcagacg aggacgtgaa gttcgtcgac gtccgcttct
     3721 gcgacctgcc gggtgtgatg cagcacttca cggtgcccgc agcggcgttc gacccagccg
     3781 agcagctgat gttcgacggt tcgtcgatcc gcggcttcca ggcgatccac gagtccgaca
     3841 tggcgctcgt gcccgacctg acgacggccc gcctcgaccc gttccgccgg gacaagacgc
     3901 tgaacgtcaa cttcttcatc cacgacccgg taaccggcga ggcctacagc cgcgacccgc
     3961 gcaacatcgc caagaaggcc gaggcctacc tcgcctccac cggcatcgcc gacaccgcgt
     4021 acttcggccc cgaggccgag ttctacgtct tcgactcggt gcgcttcaac accgcggcga
     4081 acgagagctt ctaccacatc gactccgagg cgggcgcctg gaacaccggc tcggaggaga
     4141 acaaccgcgg ctacaaggtc cgctacaagg gcggctactt cccggccccg ccggtcgacc
     4201 acttcgccga cctgcgcgcc gagatctccc ttgagctgga caagaacggc cttcaggtcg
     4261 agcgccagca ccacgaggtg ggcaccgcgg gccaggcgga gatcaactac aagttcaaca
     4321 cgctcctggc cgccgccgac gacctgatgc tcttcaagta catcgtcaag aacgtcgcct
     4381 ggcgcaacgg caagaccgcg accttcatgc ccaagccgat cttcggtgac aacggctccg
     4441 gtatgcacgt ccaccagtcg ctctggcagg gcggcatccc gctcttctac gacgagcagg
     4501 gctacgcggg cctctcggac accgcccgct actacatcgg cggcatcctc aagcacgccc
     4561 cgtccctcct cgccttcacc aacccgacgg tgaactcgta ccaccgcctg gtccccggct
     4621 tcgaggcccc ggtcaacatg gtctactcgc agcgcaaccg ctccgcggcc atgcgtatcc
     4681 cgatcacggg ctccaacccg aaggccaagc gcgtcgagtt ccgcgccccc gacccgtcct
     4741 ccaacccgta cctggccttc tcggccctcc tcctcgcggg tctggacggc gtcaagaaca
     4801 agatcgagcc ggccgagccg atcgacaagg acctctacga gctggctccc gaggagcacg
     4861 cgaacgtcca gcaggtcccg acctccctcc cggccgtcct ggacgccctc gaggaggaca
     4921 acgagtacct ccaggcgggc ggcgtcttca cctcggacct gatcgagacc tggatcgact
     4981 acaagcgcac caacgaaatc gccccgatcc agctccgccc gcacccgcac gagttcgagc
     5041 tctacttcga cctctagaga acgcgcaggt caggaccgct ctttagcgct ctgggccgta
     5101 cctgggccgc gggccgtgcc cttccccgat caggggggag gacacggccc gcagtcgttc
     5161 ggcctaacgt cgcgagccgg ggaaccactc agctactgag cgatggcgcc gactccgcct
     5221 gggcactacc gaaggaagac caacctttcc gccagttcgt cggccaagcc gggtggcaga
     5281 tcagcgtagt cgtcccgttg ctcgatgagc tcgaagccat gacgctcgtc gcggacccgg
     5341 acaacgcgac gcgtcgcaag gtgagttcgt ggccgtcgcc atgcggaacg gcccggacgg
     5401 atcgtgtgtc ccgtccgagg ccttggcccg tgcccctggc atcggggcgg aactcgcgcc
     5461 ccgcccaggg tgcggtgttg cgccgtccgc aggccgctga gggtccgcta gcggcccggc
     5521 ttcggatgag tggccgtctc gggacacccg tcgcggtgac tgtagttgac cagcggcgcg
     5581 ccggtccccc ggtcgtgaac gtgcctctcg tacggctcgc ccggcttaat ggcctgatcg
     5641 cagcgacagc agatcacaac gcgcgtatct ctccgtacgg ccctcagtgc gtccgcgagg
     5701 tgctggccct ccgggcacag ggccggggtg ctgcggcacg cctcgcactg ggcgccgtgg
     5761 tcaagcagcg ccacgtaggc cgtcgcgtcg cggtcgtgtt cggcaccccg cgccgggctc
     5821 accggggtca gaccgggatg cctgtcgtcg cgcggctgct cgctcatgac gccacgcccc
     5881 gcgcgccgac caggtggcgg tcaaggtcga cgccgaagtc agccgcgagt accagagcca
     5941 ggcaccgccg ccgctgacgt gcccgttcct gccgctcctc gtgctcggtc aagtacgggc
     6001 ggaccagggc cgtttcctcg ccgtccagcg gcgtgtcgag cccgtacggc gaacggggcg
     6061 cggggagcca ctcccgcgca cgtcgcgccg cgacgggtac gggtacgggt acgaggtgca
     6121 gggatgcccg tgcgggtgcg gggcgaacgg tcgggcgggg gcgttggcca ccgccccctc
     6181 gcaagccgaa gatcagactc gcccacagaa tcagggcatg gataagctcg ggcatgtcga
     6241 cgctccttcg aagcgttggc cacgccccgg gagtcctgac cgactcgccg gggtccttgt
     6301 tctcacgata accgatgccg aaagcgtccg gcagtggacg gcagtggttg acagtagttg
     6361 acagttgtcg gagatgcatg agcgctgccg gacgcttacg ttcgattccg tgacagacaa
     6421 gatcaacccc ggtgctgccg cctaccacta cgaacagctc gcgaagatcc ttgagggcaa
     6481 gatcagaagc ggggagcttc cggcgggaac gagactgccg ggcgagatgg tcctgtccca
     6541 ggaatacgga gtcggctcca atacggtccg ccgcgccctg gagattctgc gggatcggga
     6601 cttggtcgtg acggtgcgcg cccgtggctc cttcgtcgca gagcagccgc ccgccgcggc
     6661 gcctgagggc gactgacgta cggcggcggg cttcacgttc gtgctggcgg cccgtacgct
     6721 cgctgtgacg cccgccccgg cgcggcgcgg gatatgccga tgcggggccg ccagaaggta
     6781 cccgcggcac tgcgagtgaa ggaaggggcc tcgtggcgac ggccttcagt attgccctcg
     6841 gaatcgcgtt ggcccatgcc gtcctactgg cgttcgcctt cctgttcgtc cgctttcgca
     6901 gaggcaggcg ctgacctcga cgcatcgatg acgactcggg cgccgcgtgt tacttcctgc
     6961 gccagaagcg accgcggcgt gccaacgact cctcgtacag gcgggctgtc tcgtccctgg
     7021 ccaccgtcgc caggtaggag tcgtggggtg cgcccgtctg ccagaagccg gagatcgcga
     7081 ggtcgtggac ttgcagggct tcctcgtacc gttgcgcctg tcgaaggtcg agagcgagtt
     7141 tcgccaggac gctggccgcc cagaggcggt caccatgctt ctcgcagatc gccaaggcct
     7201 gctggcggag tgtcagggcg cgctcgacca gtccggcctt gagcagggtg tctgccaggg
     7261 cgttgaccgc gctggcctcc tgggggtcgc ccagttcgtg gaaggttgtc gccgcgcggc
     7321 tgtaggcgtc gctggcctcc ggtaggcggc cgagtgcctg caaggcgtgg cccgtgttgt
     7381 agtcggcgct cgcctcgttg cggcggtcgc ccagctcgcg gaagatcgtc gcgctgcggg
     7441 tgaaggcttc cacggcctcc tcggagcggc tcgcgtcatg caggacgccg ccgaggtcga
     7501 gcagtgtccc ggcttgctcc gtacggtcgc cgagtgcggc gagcaccgcc acggcgagcc
     7561 tgaacgcgtc ggcggcctcc gagggccgtt ccgcgtccct cagcactgtc ccgagaaggg
     7621 tgagggcgtc ggcctcgccg cgtcggtcgc cgcgttcgcg ctggatgccg acggcccggc
     7681 gcagatggtc ggcggcctcg ccgaacccgc cgaccgcgcg cagcgcttcg ccaaggttgt
     7741 acaggaccgt ggcctcggca tcggggtcct cgcgtccctg gccggccgcg agggctttcc
     7801 ggaaggcgtc gacggcctcg cgatgactgc cgaggccgca gagcgtggca ccgaggttgt
     7861 tgagtgaatc ggcctcgccg aaggggtcac cgagtccgct caagagggcg gccgctcgcc
     7921 ggtgttcgtc ggcggcctgg tggaagtggc gctgggcctg cagggcggtg cctaggttgt
     7981 tccgtaccac cgcttcgtcg cgaaggggtc ctgcggtctc caggagggtc agggctctgc
     8041 ggtggacgtc gatggcctcg gctgagcgcc ccaggtgttg caggacgact cccaggttac
     8101 tcaacgcgcc tgcctcaagg ctgtcgttgc cgagttcgcg gtgttcagcc gccgcctggc
     8161 gatgcgcgtc ggcggcctcc tcgtaccggc cgagaccgcg cagcgccgtt ccctggatgt
     8221 tcagagtccg tgccgcgacg gtcgggtcgc gcagtccggc gcagaccggg agcgtggtct
     8281 cggcgacggc gagcatgctg gcgaagtccc ggcgctcgta gaggtagtgg gtgatgtgga
     8341 gggtgagtgc cgccgcggtc ctgggcgtgt cggcggcggc agcggcagcg gcagcggcga
     8401 ggacgacggc cacgaggttg cgttgctcgc cgccgagcca ggacagggcc gcgccgcgct
     8461 ccgggaaccg gtccgtgctc tgaacgggcg gcggaggcac ctcgaagtac cggtccgctg
     8521 cccgggcgcc ggtcaggtag taggcgtaga gccgttctcg ggcatcctcc cgcccgtcgg
     8581 tggcggcgca cgcgcgcccg tgttcgtcgg cgtgcaggcg taccaggtcg tgcagttgcc
     8641 agcggcccca tagagggccg gtctcgatca ggtgggcgcg ggcgaggtcc tggagcagca
     8701 gttcggtccg cagccgactc tggtcgacca ggcaggcggc ggcctcggtg gacaggtcgg
     8761 gtcctgggtt cagggataac agccggaagg tgcgggcatg gtcggggtcg agtcgctggt
     8821 acgagaggtc gaaggccgcg cgcacggcgg tgtcgcggct gcccagcagg tccaggcggt
     8881 cgtcggtgga ctccagggcc tcgcggaccg aggagagcgg acgggccgga aagtcggcga
     8941 gcagcgcggc gacgatccgc agcgccagcg gcaggcccgc gcagagtccg gcgatcgcgt
     9001 cggcgtcggc cggggagtcg gctatccggg tgtcgtcgat gtcgccagtg tcgccagtgt
     9061 cgctgatgtc gccgatgtcg cgaccggcgc gaatcgcctg atcgagcagt gctacggaag
     9121 cggcctggtc cagggcccgc acggtgtggc gccgagcgtc gaggtccaac gcgtcgcgcg
     9181 aggtgacgag ggcggcggtg gtgccgtcgg cgggaagcaa cgggccagcc tgcccggcgc
     9241 tggaagcgtt gtcgatgacg accagcacgc ggcggccctg ctcggcgaag gcggccagca
     9301 cactgcggta cagccggacg cgatcctgta gctgtgtcgg gatgtgaacc gcgggcaggc
     9361 ccaaggcccg gaggaatccg tcgagggcga ggtctggcgg cacccggcgt tccctgtcgt
     9421 agccgaacag gtcgacgaac agcaccccgc cggggaacca gcccggccgg gcgagggcac
     9481 gggacgccgc ctggacgacc agctcggtct tgcccacccc gccgagcccc gcgaccgccg
     9541 tcacaggtgc ggcaggtcgc cgccccgccc cgggggccag gccctggagg agccgttcga
     9601 cgtcggcctc gcggccggtg aacgcgcttg cgggggctgg cagtccggac agcgccgggg
     9661 tgatctccgg ggggagggtg acgttgacga tgccgccctg gatcaccgtg ctgaggaaga
     9721 ctcccccact gatgtggttc gtgagcccag ggtccatcgc accgcccctt cggattcctc
     9781 accggtacgc cgatgtcgca ccgatgtcgc accgatgtcg caccctacga ggaggacagg
     9841 cccaggcgag cggaaacggg gaggacgggt cgcgatttcg gtcgaaccca tgggtagggt
     9901 gtcactgtgc gaggtcgggt ggtagcttcc tgctgtcgtt tccgccacac ccggagcaca
     9961 aggctccgtg ggactagcgg tgcgatgagg attaccgatc ttgactcagg cgactctcgc
    10021 cccggccgag acattccacc tcacccctta caccccgcac tgccgtgtca tcgccgaaga
    10081 aggcgaccac gccgtcatcg gggtttcgtc cgggaacagc ttcttctccg ctcagcggct
    10141 acacggcctc gcccgctggg gcatggagaa cttccaccaa gtcgacttcg tctataccga
    10201 tttgcatgtg gccgacatgt tcgaggccct cggctatcca cccgacgacg cccgccgcaa
    10261 ggcggtgaag aacctgcgcg gcgtacgggc caaagtgacc aacgccgttc aggaagccga
    10321 tccgtccggg gaccgggtac gggcgcggcc catgtccgcc ctcacgctcg ctcccgccta
    10381 ccagcgtatc cacacccgta ttcaggggtt gttggagacg gaccaggagt tccgtgcggc
    10441 gtgtgagcag cttacggcga tcttcctgga cgggaagctg gcgccgggcg aagccgccag
    10501 tgcgcggcag acgcaggtgt gtctggacta tgtgtgcgcc gaggcgccgc tgttcctcga
    10561 cacccccgcc atcctggacg tcccgtcctc cgtcaactgc taccaccagg cactcccgtt
    10621 ggccgatgtg ctgtacgcac gggggcccgg cctacgcgcc tcccgcaatc agggccacgg
    10681 cattctcgtc cccgccgaag gcgagcaacg cgacgacaga ggcgatggcc taggcgaccg
    10741 tactgaccgt ggtgaccaag gagttcgact gtgactaccg ccccgcctcg caccaccctg
    10801 cccgccttcc ccttctcctg ggacgggacg cggcttcccg acgacgtcga ggcgctgcgt
    10861 gccgagcccg tgaagcgggt gcgtacgatc gccggggacg aggcctggct cgtctcgtcg
    10921 tacgcgctct ccaagcaggt gctggaggat gagcggttct cgctcaagga cacctcggcc
    10981 ccgggcgcac cgcgccagta cgccctcacc atcccgcccg aagtcgtcaa caacatgggc
    11041 aacatcaccg gcgccgggct gcgcagggcc gtgatgaagg cggtcaatcc gaaggctccg
    11101 ggccttcagg agtggctggt gaagtccgcg cacggactcg ttgaccagct tgagcgctac
    11161 ggggctccgg tcgatctgcg cggcgacttc gccgatccgt actcggctgg catgcactgc
    11221 cacatactcg gcacgcccca gggcgacgcg tcccggctga tgcgcagcct ggatgtggcg
    11281 ttcatgaact cgccgcgcag cgtggaagcg gcgcggctga actgggatcg cgatatcgcg
    11341 tacatggtcg cgcgactcga cgatcccgac ctggtgcctg gcggtctgat ggccgaactc
    11401 gccgcgctgc gcggggaccc ggactacgac catctgaccg acgagatgct cgccaccgtc
    11461 ggggtcacgc tgttcggcgc cggggtgatc tcgacggccg ggttcctgac catggctatc
    11521 gtctccctcc tcacccggga ggatgtacgg gagcagctca ccgccgatcc gtcgcgggtc
    11581 gcgggcgcga tggacgagct gttgcggatc aacctgtcca ttggggacgg cctgccccgg
    11641 atcgccctcg cggatgtcca gctgggtgat gtcacggtac gggaggggga gttggtcctc
    11701 gtcctggtgg aaggggccaa ctacgacgct gagcagttcc ccgagccgaa cgtcttcgat
    11761 ccgggccggg agaacgcgca tacgcatctg tccttcgggg gtggcgcgca ctactgcccg
    11821 gccaccgcac tcggcaagaa gcacgcggag atcgcgttgc aggccctggt ggagcggctg
    11881 ccggggctgc ggctcgcggt gccggtcgag cagctcgtct ggcgcaccaa ctttatgaag
    11941 cgccttcctg agcggcttcc ggtcgcctgg taggcgtcgc cgtaccggtt ccctgcccgc
    12001 cccccgtcca agccgccagt tggtcggggg tacgcgggcc ggtggagccg gtgggcaaca
    12061 ggccgtgcgt ggagagcagt tgggctgcgg cgatgcccca gggggtgcgt aggcccgcct
    12121 ggtggatcag gtcctggcgg gccagggcgt cagccaccgg tccggtgtgt acgcctgagg
    12181 ggatgagcag ggccgcgtcg tccgcccagt gcagggcgag gtccacgtcg tgggtggcca
    12241 tgacgaccgt cgtgccgctc gcgcgcagcc gggccagcgt ggcgaggagg cgttcctggc
    12301 cgtccgggtc caggcccgcg gtgggttcgt ccaggatcag tacgcggggg cgcatcgcca
    12361 cggcgcccgc gatggccgtg cgtttgcgct gcccgtagga gaggaggtga gtggggcggt
    12421 cgcgtaggtg cgtgatgtcc agggcggtga gggcctcgtc gatacgggtg cggacctcgg
    12481 cgtcggacag gcccaggttc atcgggccga aggacacgtc ctgttcgacg gatgccgcga
    12541 agagctggtc gtcggggtcc tgcacgacca gttggacggt ggtacggagc cgggtcaggc
    12601 ccttgcggtc gtacgtgacg ggggtgccgt ccaggagcag ggtgccgctc gccgggcgca
    12661 ggccaccgct gagcagcctc atcagggtcg tcttgccgct gccgttgcgg cccagcaggg
    12721 cgagtgcgcg gcctggcgtg atggcgaagt cgagggtgtc gatgacggtc gggccctcgt
    12781 cgtaggcgta ggacacggcc cggagttcga cctcggccgg gacctgggct gatccgtggg
    12841 ctgatccgta agccggatct tcggtttcgg gcgcgcgggg tgggggtggg ggtggtccct
    12901 gaccggtcat cccaaaggcc tttccagtac gtgatgcagg gtgagggcga cggccgccac
    12961 cgcggccagc agcgtcagcg cggctgccac gaagcgcggc gagacgcgcg cctcggggac
    13021 cagcacgcgc agggtgccgt cgtatccgcg cccggccagt ccggcctgta ggcgggacgc
    13081 acggtcgaag gcgcggacga acgcggtggc gccgagtccg gcgagtgagc gccaggtggc
    13141 ggcccgggtg gtgtgaccca gccgggcggc ctgcgcctgg cggatccgcg tcatcgagtc
    13201 caggagcagg aagctcatcc ggtacgtcac cagggcgacg tcaacgacag cggcgggcac
    13261 ccccgccttc accagccggg gcagtagatc ggacatcggc gtggtgaacg cgaacaacag
    13321 cacgccgagt gaggccgccg acgtacgcag cagaagcccc gcggcgcggg ccgggccctc
    13381 cgggtccagg gtcacaaacc cttcgggggc gcccacctgg acgagcaggg tcagggcgcc
    13441 gctgacgcag aaaccgagcg gaatacggta cgcccgccac agccgacgcg ggggcacgcc
    13501 agcgggcccg agcagcacgg tcagggccgt gacgatgacg agcgccgcgc ccggccaggg
    13561 cgggagcgag atggccagta cggtcagccc gagtccgagt acggccttgt ccacggggtg
    13621 acggcggcgc cagcgactgc tgtgcgccgc cgcgtcgatg ggcagcacgg gtgagggccc
    13681 cgcctagtcg ccgctaggcg aagcggcggt ctcggcgttc tcggcgttct cggcgttctc
    13741 ggcgttcttc tcgtacgccg cccgcgcccg cgcctccccc tgcctgcggc cccggtgcac
    13801 cccgaagtag tacgccagca caccggcgcc gatcgccgcc tggagggcga acagggctga
    13861 ctcgacctcg cccgacggag gttcgtagag cggggtgaac catggctcgt agccggggtc
    13921 gatctcggtg atcgcaccct ccgcctcgcc gtcggctccg gcgaacggct cctccttgtg
    13981 gtcgccgagg cccagcgcca gcgggagcac cgcgagcgcg gccaccacca gcaacagcaa
    14041 ggtgttgatc ttcgcgttct tggacatgct catcgggact ccacctccgt gccctccgcc
    14101 gcctgcgcac ccttcgccgc ctgcgccgcc tgcgactgct tccgcgtcaa cagcaccccg
    14161 agacgcgtca gctccccctt gctggaccgc accaaaagcc gcatcaccag caccgtcagc
    14221 agcccctcgc tgatggccag cgggatctgc gtcaccgcga agatcgagcc gaacttcccc
    14281 agcgccccca ggaacccgct gctcgggtca gtgaaggcca gcgccagctg gacactcgtg
    14341 acgcagtacg tggagaggtc cgcgacgaag gcgccgccga agaccgcccc catcagcggc
    14401 acatcgaacc gcctcagcag ccggtagacg ccgtatcccg cccacggccc gacgatcgcc
    14461 atcgagaaga cgttggcgcc gagcgtggtg agaccgccgt gggcgagcag cagcgcctgg
    14521 aaaagcagcg tgatggtgcc aagtacggcc atgatcggcg gccggaagag aatcgcgccg
    14581 agtccggtgc cggtcgggtg tgagcagctc cccgtgaccg acgggatctt cagcgcggaa
    14641 agaacgaaag tgaaggcccc ggacgcgcca aggagcagcg tgctctcggg gttggacttg
    14701 acctcacggg tcagggcacg tacgccgtgg atgacgaacg gcgccgccgc ggcgctccag
    14761 gcgaccgcgt gtaccggtgg tagaaaaccc tcggctatat gcatggctga gcagaccctc
    14821 tccagcacct cgtggatgga caacgcgcct tggccggtct cctggcttac gggtcatacc
    14881 gccctgactc cgccttcccg ggtacgtgga gctacccagt ggctgcccct gggggctgga
    14941 gccggacttc ccgatcacag tggcgagggc cgcgtcggca tcacaccgat ttcccgtacg
    15001 ccaaggcgtg gtgacactag tccgctggtg ggggccctga caactacggg ccgtggccag
    15061 tggttgaccg gcccgcgatg cgctacggct aagggcagcc gccctggaag acgtgctcgt
    15121 aagtgcgcag cagcttgggg gccttggcgc cgccctttcc gtcggccttg cccttcggct
    15181 gcggtggcgg cgggtactcc atcaccggga ccggcttgca caccggccac tgctcggttt
    15241 cgcgcgcgtc gtcgaagccg aacgtcccgg aggctcccag tacgcagctg acgcagctgg
    15301 caccgtcctc ggtatcgagg atgcccatgt tgatgatggt ttggtagata tcgtccgtgg
    15361 tcggcatgac cgggggggcc gtgcccgtgt ccgtgcccgt gcccgtgtcc gtgtccgcgt
    15421 ccgggtcaat ggcgttgatc tcgttgtagg cctggtcgaa ggcctcggag agcaccgtga
    15481 aggagtcccg gtacatgatc gagtagccgt cgtccagcgg ccgctccccc agctcgtgtt
    15541 tcttctccac ctcctcgaac tgctccagga agtgggccag cccctccggc cgctccttgt
    15601 gggtcttgtc ctcccaccac gcggggtcca ccgaagccgc gttcaccagc gtgatgttgg
    15661 cgtcccgcat ctgctgggtg agctccggct tggagtgctc ggtgtcgagc ccgatgccca
    15721 ccttcaggat gcgcagcggc ttggagttgt cacaggcggg ttccttgacc aggtggcgga
    15781 tcagatacgg caggtcacgg tcccgccccg cgaagaagac cgtgtccgag ccggtcacgc
    15841 agaccttctg ggcgacggag gagaagcggc gcgggattcc ggcgtcctcg ccggtgatgc
    15901 ccaggtagta ggcccggttc ttgtccagtc cgtacgtatc gctgaagcgg tcctcgaact
    15961 gatcgcgcag gtcgagcgag taggcgtcct tctgccggtt gtccgcgacc aggaatcccc
    16021 ggtcgcctgg ctccttggcc aggtacttga ccagggcgtc caccaggagc gcgttcgacg
    16081 gggaggtctt gaagaggtac gagtccttca tcgtcgtccc cgtgaggatc ggcccgaccg
    16141 agggaatccg gtgctcgccg agcgcctcga ccgccttgag ggtctccggg gtgctgctgg
    16201 gcatgccgag cacgccgacc agcggggatt cgtcgtccgt catcccgatc agccggtcca
    16261 cggccgggcg ccacttgtcc aggtccttgc cgtcgttggc cagcagcagc tgatagtgcg
    16321 gacccgttgc cgcgttggcc tccagctgtg ccgtgtaggc gcccgccagg gcgcgcctca
    16381 tctcctcggc ggtcatggtg ctggtgtcgt cggaggtgaa gggcatcatc agcgcgatcc
    16441 gcgcgtaggg gatccgcggg ctgccctttt ccggggtctc ccaggccttc ttgacgctgg
    16501 cgttctcctc cgcgatggcg gtgatcaggc tttggatctc cgggtcgccc ttcagcgagt
    16561 cggtggccgt gacgcccacg cactcgccgc cgacctcctc caggccctcc ccgcactcgt
    16621 cggggagcag cgtgacgacg agcaggccga ggcctacgag gagcgcgagg cagaccaccg
    16681 cggcgatggc cttgtccagc ggtccccaga cgtggtttct ccagcgcgtc agcatggctg
    16741 tggttcctct cctctcgcga cggtcgtcac ggtcgtcacg gttcgatggg gcggggccag
    16801 cggtggcgta gtgccaccgg ccaggtctgc gcggcgcggt tcagtacggc gtgcccggtt
    16861 ggatggcgta cggagaggaa ccgcagctcc gtacccacgc cctcgcagag gtcgtccagc
    16921 ggctcggcga acggttcgcg caggtaccag acggcgtgca gcagccggtt gacggaacgc
    16981 gcgatggtgc cggtatcgcc tgggccgcct gtgccgcctg ggccgtctgt gcggccggtg
    17041 tcagggtggc ggtggtcgtg ggcgccacgg gcgatctccg cgcgatcgtc cctccagtgg
    17101 gccaggggtg ggtggggtgc ggtgctgatg tgccgcaggg cgcgcagcca gtccgccgcg
    17161 tccacgtcct ggcggccgaa gtcctgggtc agccgggcca ctacgggctc cgcgccgaac
    17221 ccggcgagcg tgtgccgcag tacgtcggcc acgtgtgcgg ggccgagcgt cgcgtagtgc
    17281 tcgcgcagga cgatgtgggt gccgtcccag cggcgacccg cgtcggctcc cccgcgcgcc
    17341 tggtggatca gcaggtcccg caggaagggg tcgggcacga atcgcggcga accgccggga
    17401 gtgtcggggg tgttgtcgtc ggccgcctcg ccctccggga cagcggtcca gtgttcttct
    17461 tccaggtatc tggcggcctc ggcggcgggc agcgggtcgc ctccgatgcc cgtcgaccgg
    17521 gcggccagag cgtcggcggc ggcgcggtcg ggggccgggg agagcaggat gaggtgatcg
    17581 cggtgctgag ggtgcgggat cagccgctcc agcagcagct cggtgaccgg gcggccgtcg
    17641 tgggcgggca ggtcgagcaa ctcctcgggg cgtacggtgc gttcacccgc cgtgcggacg
    17701 accgccgcgc cgagcagggc gctgccctct gggtggccgc gggtgagtgc gtgcagggcc
    17761 gcgggcaggt ggcggtgcag cggcgcgtcg gcacggtcga gcatcagcag tacgtcgtcc
    17821 aggtcgagcg gcgcgagcgg aatgaccagc agtccggccg acggcgacgc gggggcggta
    17881 cgggaccagc cggaggtggc gaggacctcg gtgaggcgac gtcgggtggc gtccgggtag
    17941 cggctcgtgg tggtgtcgcc gagccgggtc gcgatgacga cgagcgggtc gtgggtgtcc
    18001 ggggccgccg cgcgctgctg gaggatgagg tcgagtaact cctcaccggc ttcggtgtgg
    18061 acgttgtcca ggaggatgag gggccggggg gtgcggttcg cccgctgcca gcgcccgtag
    18121 gccccggtga cgtcttcggt gaaggcggcg accaggaggc gttcgaccgc gtggcggtag
    18181 gcgccacctt ggtggaagcg gaggcagagc cgcaccaacg ccgcctcgcc gtcggccgat
    18241 ccgggaacgt gtccctggta ccactcgcgc gcggtgcggc cgggacgtgc cttggtgtgc
    18301 tggtggaagt accgcgcgat gacggcggtc gccacggcct ccagatcctg ctgcccgccc
    18361 gcgtcggcca ggccctcgct gatctcgtac gtccagtcct ggaccccgcc accttccggg
    18421 cccgctccgg agtcctcgcg caggtcgcag gccgtgagca ggcggtcgat ccggtcgcgg
    18481 gccaggcgcc gttcgtggtc gccgccccgg tgccagctgg agatggcgaa caggccggga
    18541 agcagccggg ggaagacggg acggccgggt cggccgaggg tgggcgcgag gtcgcaggcc
    18601 agttggacga gtacctccac gaccgtggag gcgttcgacg ccgcgaagcc ggtatggcgc
    18661 gcggggtcgg cctccgacac atcgacgcgg ccgagcggga cgcgaccccg gtacgccgcg
    18721 tccagggcgg ccagcaccgc ggtcttgccc atgccgtggc ggccggtcag caggacgacg
    18781 ggctggtcac ccgggtgttc ctggcggacc agttcacgct tggccggtgc caggccgacc
    18841 agtcggggca ccagggcgtg cagcaacggg tcacgcgcgt acagctggga ccgcatgctc
    18901 ctcctctgcc atggggacgg ggtcaccggg tggtgagcgc gtcagccgcc gagcagcctc
    18961 cccagggcct gcccgatcgc gtcgagcgcg acctgtcggc ccaccgtgtc gggggtgccg
    19021 cccagcaggc tcctgacccg ttccatcagg ccgcgctggc ggtccgggtc tggtgcgccg
    19081 ccacccgggt caccgcctgg atcgccggta cgcgccaggg cggcggcgct ggccagcagc
    19141 gccgcgcgag cctcgtcgtc cagggccagg acgggcgcta actgctggat gaggctgccc
    19201 agttcggcgg gcgagagggc ggtctgaacc gacacggtgt ggtggaagtc gccctgcgcg
    19261 tagttgaccg tcgcggcctc gatatgggtc tgctgagcgc gctggcgctg ccgcgccacg
    19321 aactccccta tgccacccac ctcgccctca ctgagcacgg cgtccgtacc gagggcggtc
    19381 agcgccactt ccgagccgac accgccttgg aactccggcc ccgtgcaggt gatcagacgc
    19441 gagtcggcga ggtaggacag cgcgcgggcc acttcggagc gggaaagcgc ctcaccgagg
    19501 aagaacactt cccccgagtc gaagaaggcc tcgatccgca gtggctggcg gtcggaggac
    19561 gcgtagatcc agcgcagtac ggcgctggtg gcgtgtcggc cgcggcgtac ggggtcggct
    19621 ctgcgggcct ggagcagccg ggcctcggcc acgcccgcgg gcagcagggt gaccacgggg
    19681 gcgtgctgcc tggagccctg cgcgctgatc aggagctgct cgctgaggcg gtcgacgagg
    19741 gaccacacgg tgctctgcgg gatcgcctgc cagatgccga actcggcgca gggaaccgga
    19801 agatccgggt cccgcatgac ccggtcccag acccatagga gcaggcggga gcggtaccgg
    19861 tcgaagctct cgctgtcggg gtccgggaac gaaggtgctg cggctgacaa ctggctcagt
    19921 cctgttcatc ctcggccgtc ggctgggtgg gtggcacatc cgggtgagct cactcgcacc
    19981 ccgaagttac acaggttgca cgcgcatcac cacggaaagt caaaagtcaa ctaccttcct
    20041 tccctcagga gttcaccgca tgcgcgcacg aatggatcaa acgttctgac gcgggcggtc
    20101 agccgcgccg gtcagtcagc cgtgctgggc gaaggcctcg gcgatctcat cccgcccggc
    20161 cccggcggag agcagcagac gcagcaggac gcgcgccttg tacgggtcga ggaagccgcc
    20221 gcccagcagc ccgcgccgga gcagatccgt ctcggagccg atcgcgccgt aggtgcggct
    20281 cagcaccggg cccgccccgg tccgtgaggt aaggatgacc gggatgcggg cggccaggcc
    20341 gccgagtacc ggcgccagca ccgaggggac atggccgacg ccgaacccgg cgacgaccag
    20401 gccctggtgg gtgcggtcga gcccgtcgag cagggcggcg tcgtcgtcga gggtgacggt
    20461 gtgcagggcc acccgcgccg ggtcgccgcc ggggtgcagc ggccgatgac ggggcggccg
    20521 ggtcaggacg cgcggctcgc cttcgacgac gtggccgacg gggcccgtgt cgggggacgc
    20581 gaaggcggcc gtgctggtgc tgtgcgtctt gcggacccgg cgcgcggcat ggatctcgtc
    20641 gccgagcacg accagcgcgc cgagttcccg tgcgacgggc gcggcggcga cacgtaccgc
    20701 cgcgagcagg ttggcggggc cgtcggggcc cgcgagggtc gggttgcgca tggcaccggt
    20761 gaagacgagg ggct
//
