LOCUS       NZ_WOFH01000016        21086 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Actinomadura litoris strain NEAU-AAG5 Scaffold16, whole genome
            shotgun sequence.
ACCESSION   NZ_WOFH01000016
VERSION     NZ_WOFH01000016.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura litoris
  ORGANISM  Actinomadura litoris
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 186913)
  AUTHORS   Cao,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2019) Northeast Agricultural University, College
            of Life Science, No. 600 Changjiang Road, Harbin, Hei Longjiang
            150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 109x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009733595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 03:46:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,194
            CDSs (total)                      :: 8,115
            Genes (coding)                    :: 8,044
            CDSs (with protein)               :: 8,044
            Genes (RNA)                       :: 79
            rRNAs                             :: 5, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 1 (5S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 14 of 71
            Pseudo Genes (incomplete)         :: 60 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:00:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 120944
            Orig. end                         :: 142030
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WOFH01000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(333..1616)
                     /locus_tag="GNZ18_RS35315"
                     /old_locus_tag="GNZ18_35330"
     CDS             complement(333..1616)
                     /EC_number="3.5.2.3"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853340.1"
                     /locus_tag="GNZ18_RS35315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35330"
                     /product="dihydroorotase"
                     /protein_id="WP_156220999.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.1e-18, bitscore:
                     61.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHLIRGARILGGAPADILVRNGQIAEIGTGLDAGGAQAVDADGL
                     VALPGLVDLHTHLREPGREDAETVESGTKAAAMGGFTSVHAMANTDPVADTAGVVEQVW
                     RLGREAGYCDVQPVGAVTRGIAGEQLAELGAMADSAARVRVFSDDGHCVSDAVIMRRAL
                     EYVKAFGGVVAQHAQEPRLTEGAQMNEGEMSAALGLRGWPAVAEEAIIARDVLLAQHVG
                     SRLHVCHVSTAGSVEIIRWAKSKGCPVTAEVTPHHLLLDDTRAGTYDPIFKVNPPLRTA
                     EDVAALRAALADGTIDCVATDHAPHPVEAKETEWAVAAMGMIGLETALPVVQEAMVETG
                     LLDWAGVAERMSLSPARIGRLSGQGRPLEAGSPANITLYDPSPRRAVDASEMTSKSRNT
                     PFAGLALPGRVVATFLRGTPTVLEGKLQ"
     gene            complement(1613..2554)
                     /locus_tag="GNZ18_RS35320"
                     /old_locus_tag="GNZ18_35335"
     CDS             complement(1613..2554)
                     /EC_number="2.1.3.2"
                     /GO_function="GO:0004070 - aspartate carbamoyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016597 - amino acid binding [Evidence
                     IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853341.1"
                     /locus_tag="GNZ18_RS35320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35335"
                     /product="aspartate carbamoyltransferase catalytic subunit"
                     /protein_id="WP_214617762.1"
                     /transl_table=11
                     /translation="MKRHLISAADLTREDALLVLDTAEELEKVAGRSIKKLPTLRGRTV
                     VNLFFEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTALTLEAMGADGVVV
                     RHGASGAPHRLAGWVQGSVVNAGDGTHEHPTQALLDAFTMRKRLGDLEGRRVTIVGDVL
                     HSRVARSNVLLLGTLGADVTVVAPPTLLPVAINTWPCQVSYDLDAVLPKSDVIMMLRVQ
                     QERMNAAYFPTVREYSRRYGLDGERMAALPEHAIVMHPGPMNRGVEIAAEVADSVRSTI
                     VEQVANGVSARMAVLYLLLGGSEPAIGTEVTE"
     gene            complement(2551..3111)
                     /gene="pyrR"
                     /locus_tag="GNZ18_RS35325"
                     /old_locus_tag="GNZ18_35340"
     CDS             complement(2551..3111)
                     /EC_number="2.4.2.9"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853342.1"
                     /locus_tag="GNZ18_RS35325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35340"
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="WP_242892297.1"
                     /transl_table=11
                     /translation="MADGDPRPKAVLEGPDIRRALTRIAHEILERTKGGHDVLLLGIQT
                     RGVTLAERLAGLLGDVEGRPVPWGSLDVTMYRDDLRMRPARALGRTEVPQDGVDDRVVV
                     LVDDVLFSGRTVRAALDALNDLGRPRAVQLAVLVDRGHRQLPIRADYVGKNLPTSMRET
                     VRVLLGENDGRDAVLLGPAGGDR"
     misc_feature    3266..3281
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     misc_feature    3393..3406
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.59"
                     /tool="antismash"
     misc_feature    3394..3407
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.29"
                     /tool="antismash"
     misc_feature    complement(3423..3439)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.64"
                     /tool="antismash"
     gene            3560..4054
                     /locus_tag="GNZ18_RS35330"
                     /old_locus_tag="GNZ18_35345"
     CDS             3560..4054
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622275.1"
                     /locus_tag="GNZ18_RS35330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35345"
                     /product="transcriptional regulator"
                     /protein_id="WP_067463081.1"
                     /transl_table=11
                     /translation="MPSEYAKALGARLRAIRTQQGLSLHGVEEKSRGRWKAVVVGSYER
                     GDRAVTVQKLAELADFYGVPVSELLPGGAAPSPLGPTPKLVIDLERLQQLPKDKAGPLA
                     RYAATIQSQRGDYNGKVLSIRQEDLRSLAVIYDKSPNELTEELITWGVLDPEARRAVES
                     F"
     gene            complement(4446..4940)
                     /locus_tag="GNZ18_RS35335"
                     /old_locus_tag="GNZ18_35350"
     CDS             complement(4446..4940)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853345.1"
                     /locus_tag="GNZ18_RS35335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35350"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_156221000.1"
                     /transl_table=11
                     /translation="MSETTTARGVHSAAQFGPPGPRSRPKPAPRPAHTAVGQLHAARMG
                     LAEAAEATSPAVRYVCAHLAALRAAAAVLASKEPLETHRRGRPRSVWVLLPEAEPALRE
                     WAAFFAAGADKRAAAEAGLPRAVTPREAEELLHDAEVFVTLVEDTLGVTSQPTLPIPEA
                     S"
     misc_feature    complement(5081..5096)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.93"
                     /tool="antismash"
     misc_feature    5082..5095
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 24.0"
                     /tool="antismash"
     gene            complement(5197..6042)
                     /locus_tag="GNZ18_RS35340"
                     /old_locus_tag="GNZ18_35355"
     CDS             complement(5197..6042)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658570.1"
                     /locus_tag="GNZ18_RS35340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35355"
                     /product="L,D-transpeptidase family protein"
                     /protein_id="WP_156221001.1"
                     /transl_table=11
                     /translation="MRKSAALLIPIVLLAGCKTAGEAAPADAGRSSRPHKPSADRPKHK
                     PKREPVRKPRARATPKPSPSRPVPPLRAGDRKLRPGAEGADVRELQRRLKGLHYDPGVV
                     DGEYGTSTQLAVWAFQAVNRLKQSGTLGAPFWKALDRPREPRPMARRHEADRVDVDLRR
                     QYLVLYRDGRPRLITHVSSGSGEYYCAKDRGATVARCRYATTGTGDFRTGRRAKGWEVS
                     PLGRLYNPVYFNGGIAFHGALDVPRYPASHGCVRLPMHIAEYFPSLVGTGVAVHVRRLG
                     "
     gene            6088..6552
                     /locus_tag="GNZ18_RS35345"
                     /old_locus_tag="GNZ18_35360"
     CDS             6088..6552
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291495.1"
                     /locus_tag="GNZ18_RS35345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35360"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_156221002.1"
                     /transl_table=11
                     /translation="MHANAERVARALEAQGATGKIVELPDSARTAQAAADQLGCEVGAI
                     ANSLVFDADGAPLLVLTSGAHRVDTARVAALVGAEAVRRATPEFVRDATGQPIGGVAPL
                     GHPAPIRTLVDVWLDKYDEVWAAGGHPHTVFPTSYEELLKITGGTPAEVG"
     gene            6554..6937
                     /locus_tag="GNZ18_RS35350"
                     /old_locus_tag="GNZ18_35365"
     CDS             6554..6937
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658568.1"
                     /locus_tag="GNZ18_RS35350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35365"
                     /product="ArsC/Spx/MgsR family protein"
                     /protein_id="WP_156221003.1"
                     /transl_table=11
                     /translation="MGDDAQGDARGTELWHNPRCSKSRAAKAALDEAGVPYTERRYLDE
                     PPTAAELDAALTRIGAEPWDVARLNEPVAKELGLRSLEHDRARWIEIMVANPVLIQRPI
                     VLTRAVAVVARDGESLRRALDSR"
     misc_feature    complement(6564..6577)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.97"
                     /tool="antismash"
     gene            7015..7899
                     /locus_tag="GNZ18_RS35355"
                     /old_locus_tag="GNZ18_35370"
     CDS             7015..7899
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS35355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GNZ18_35370"
                     /product="hypothetical protein"
                     /protein_id="WP_156221004.1"
                     /transl_table=11
                     /translation="MTAQMRSGPAARDPEFRGIDPPALDRVIRQLQDAQNAIQGWLNGH
                     RPPPGVPATGYRQADQVALWAADQLGMLTRRYNYAITHPDGGGVDVPPVHAPSPKPSPG
                     GNPGAGGGVQPGRPGATAPRTPSPGTPGTPGRRHPVRPPRHTAPPTSRGAGDLGNFPTR
                     QAAARAARADALAVAAAVRDGDPVPDGVWKHLRANADDPDYTEALYERLGPASAAALVK
                     AAHGDAALLQALRQALGTSSHHLAMDTAWLRAFLAEADREGVRPVAVQVLTGADLSPRT
                     RDALAGLHQKAGG"
     gene            7902..8246
                     /locus_tag="GNZ18_RS35360"
                     /old_locus_tag="GNZ18_35375"
     CDS             7902..8246
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630829.1"
                     /locus_tag="GNZ18_RS35360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35375"
                     /product="hypothetical protein"
                     /protein_id="WP_214617759.1"
                     /transl_table=11
                     /translation="MSSPSSAPPPPGSLPPPIEAAAAVGLPPTERPNPEYGQLYQAYAD
                     AYGSIDRLRRALDASARTLGSTDAWLGPEARQWGGQLDANRNALRKAADRILWDIYDRL
                     NATQRTIAKL"
     gene            8359..8961
                     /locus_tag="GNZ18_RS35365"
                     /old_locus_tag="GNZ18_35380"
     CDS             8359..8961
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630830.1"
                     /locus_tag="GNZ18_RS35365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35380"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_214617758.1"
                     /transl_table=11
                     /translation="MRDPKLREIDERAFLRRLGPMLEVYAATMAPPAEQLPGRHTIMER
                     HAAYPGFRAFVAERRGPLPGLAGPVQGFAYGFHGSRGQWWHDIVHQALAAREGPEHADA
                     WMDDPFEVAELHVHPAAQGKGLGRGLLTALCEGRPERTVVLSTLDLRSATPAQRLYRSV
                     GMVDLLTGFEFPGGGPLYAVMGGTLPLAPYPSASSSP"
     gene            complement(8898..9830)
                     /gene="metF"
                     /locus_tag="GNZ18_RS35370"
                     /old_locus_tag="GNZ18_35385"
     CDS             complement(8898..9830)
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630831.1"
                     /locus_tag="GNZ18_RS35370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35385"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_156221005.1"
                     /transl_table=11
                     /translation="MRRLRPDRPPTVRELLASGRSFSFEFFPPKTEKGARNLWRTIREL
                     EPLHPSFVSVTYGAGGGTRDKTVDIVERIATDTTLTPVAHFTAVDHSQAELRQLIGRFA
                     AVGVRNILAVRGDPPGDPMGEWVKHPDGVEYAADLVRMIRSYGDFSVGVAAFPYKHPRS
                     PDIESDTRHFVAKCRAGADYAITQMFFRADDFLRLRDRVDAAGCDVPIIPGIMPVTQIS
                     TIDRSEQLSGAPFPADVRARFEAVADDPEAVRRLGIEHAAQLCRDLLDQGVPGIHFITF
                     NKSTATREVYGLLEADGYGARGSVPPMTA"
     misc_feature    9939..9957
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.64"
                     /tool="antismash"
     misc_feature    complement(9940..9958)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.25"
                     /tool="antismash"
     misc_feature    complement(9978..9996)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.39"
                     /tool="antismash"
     gene            10001..11086
                     /locus_tag="GNZ18_RS35375"
                     /old_locus_tag="GNZ18_35390"
     CDS             10001..11086
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853353.1"
                     /locus_tag="GNZ18_RS35375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35390"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_173390990.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 9.6e-48, bitscore:
                     156.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSPIRKEVDGALLAFVARQRPNLLAISDELAPLMAALDALLAE
                     GKRLRPAFCYWGWRAAGAVEEDLDGPPGERLHEGIVNAAASLELLQASALIHDDVMDSS
                     DTRRGQPSMHRRFEALHRAQGWPGPARAFGEGTAILLGDLCLAWSGEMFETCGLDEERR
                     RRGRAVYDLMRTEVMCGQYLDMLEGTRGEAAVDTALRVVEFKSAKYTIERPLHLGAALA
                     GGAPEVSAALTGYGVPLGIAFQLRDDVLGVFGDPAETGKPAGDDLREGKRTVLVALTLE
                     RATPAQAAALQRRLGDPGLDRPGVDELRQIITDTGGLAACEAMIARYTGDAERVLAAAP
                     VPEEARAALNALAVAATARRT"
     gene            11156..12268
                     /locus_tag="GNZ18_RS35380"
                     /old_locus_tag="GNZ18_35395"
     CDS             11156..12268
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630835.1"
                     /locus_tag="GNZ18_RS35380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35395"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_156221007.1"
                     /sec_met_domain="Pkinase (E-value: 3.6e-45, bitscore:
                     147.8, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKSSSVPAESESAVPHDTSRGRANPHHPRPAARSAGGAPPRAGQ
                     PRGGKPRAAEPHPRAARPARPRHPGSPLWAGDPGSLGGYTLLGRLGEGGQGVVYLGEDG
                     DGALVTVKLLRGGVAAGQRARGRFVKEADAARRVEGRHTARVLDADVTGDRPYIVSEYV
                     EGPSLQQVVEDRGPLPAPRLHKIALRTAGALAAIHRAEIVHRDFKPGNVLLGPDGAKVI
                     DFGIARTADATPVTTGPVGTPAYMAPEQIEDEPVGPPADVFAWGATLVFAATGRPPFGT
                     GPSAAVMRRVTSRPPDLGELEGPLRELAARCLDKNPAARPTARQLVRALRDGQAPAAKP
                     RPKRIPRYRWRMMVALAVVVTAGFALGVLF"
     gene            complement(12270..12428)
                     /locus_tag="GNZ18_RS41025"
                     /old_locus_tag="GNZ18_35400"
     CDS             complement(12270..12428)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853355.1"
                     /locus_tag="GNZ18_RS41025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35400"
                     /product="hypothetical protein"
                     /protein_id="WP_173390987.1"
                     /transl_table=11
                     /translation="MGPDDDRLVHLDDDDLDVLPDQTSDDTDTGWGEWRGGVSDDDRLL
                     EERPPHW"
     gene            complement(12544..13203)
                     /gene="thiE"
                     /locus_tag="GNZ18_RS35385"
                     /old_locus_tag="GNZ18_35405"
     CDS             complement(12544..13203)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630837.1"
                     /locus_tag="GNZ18_RS35385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35405"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_156221097.1"
                     /transl_table=11
                     /translation="MPTEQGVALRARLSRARLYLCTDARERQGDLPEFLDAVLAGGVDL
                     VQLRQKGLEARQELEYLEVFRAACDRHGALMAVNDRADIARAAGADVLHLGQDDLPVPA
                     ARAIIGEDVLIGRSTHSDGQAGAAAAQAGVDYFCAGPVWPTPTKPGRAAPGPELLERVA
                     GRRGSRPWFAIGGIDLGNLDEVLAAGARRVVVVRAITEADDPGAAAAAFADRLPPA"
     gene            complement(13358..13732)
                     /locus_tag="GNZ18_RS35390"
                     /old_locus_tag="GNZ18_35410"
     CDS             complement(13358..13732)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853357.1"
                     /locus_tag="GNZ18_RS35390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35410"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_156221099.1"
                     /transl_table=11
                     /translation="MHATVDSALDPRTDALAGEWLSLRETADRLGIKTNRIKQLISERR
                     LLAIRRAGEPMVPAAFLKDGQVIKGLAGTLTLLSDAGFDEVETVRWLFTADDTLPGTPV
                     EALSENRGTEVRRRAQALAF"
     gene            complement(13811..15019)
                     /locus_tag="GNZ18_RS35395"
                     /old_locus_tag="GNZ18_35415"
     CDS             complement(13811..15019)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889487.1"
                     /locus_tag="GNZ18_RS35395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35415"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_156221008.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.7e-46, bitscore:
                     152.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSVIVVGGGLAGLRAAQGLREGGHTGAITLVSAERHLPYDRPPL
                     SKDVLAGAADDTTLEADWDALRCEVLLGERATGLRLDAPGAGGALASTAGELRFDGLVI
                     ATGAAPVTLPGGGRQRVLRTVEDALDLRAALVPGTRLAIVGAGWIGAEVATAAAAKGCA
                     VTVVEAAEAPLASALGPEVGALTARWYAEAGVGLRTGVKVAAVEDGGLALAGGERIDAD
                     EVVVGVGVRPVLGWLEGSGLLLERGVVTDASFRATGADGAPRPDVVAVGDCAAWWSARY
                     GRRLLVEHWDTALNAPAVAAAALLGRDAAYDAVPYFWSEQFGRMVQYAGVHGASERLVR
                     RGDPAEAAWAVVWLTGDRLDAILAVGRPRDLVQARRVIAAGTPVDPAALADPGVPVRQA
                     VRA"
     regulatory      15105..15218
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(15175..15188)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            15208..16332
                     /gene="thiO"
                     /locus_tag="GNZ18_RS35400"
                     /old_locus_tag="GNZ18_35420"
     CDS             15208..16332
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591122.1"
                     /locus_tag="GNZ18_RS35400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35420"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_156221009.1"
                     /sec_met_domain="DAO (E-value: 7.7e-72, bitscore: 236.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIVILGAGIIGLATAWRAAAGGAAVTLVDPAPMSGATSVAAGML
                     TPVSELTYGEEPLLRLGLASRDRYGAFVAELEERTGLDVAHRTDGILEVAFDSGDLNHL
                     DDLRRFQESLGIPTEALTGRECRRHEPMLAPGVRGGLLAPEDGSIDPRRLAPALLAAAE
                     GLGARLVRRRAAGVLVERDRAAGVRLDDGTEIRADRVLLAAGSWSGDLEGLSAGVVPPV
                     RPVKGQVIRLRTAVPFLRRSTRALVRGSSVYLVPRADGEIVVGATQEELGFDTRVTAGG
                     VWELLRDAHELLPGITELEFAEVSAGLRPGSPDNAPVMGPSALPGLFLGTGHFRNGILL
                     APVSADILAAMLLDGPVPAEAAPFTPDRFSPEVH"
     gene            16332..16532
                     /gene="thiS"
                     /locus_tag="GNZ18_RS35405"
                     /old_locus_tag="GNZ18_35425"
     CDS             16332..16532
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017541361.1"
                     /locus_tag="GNZ18_RS35405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35425"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_156221010.1"
                     /transl_table=11
                     /translation="MKVIVNGEPREVPEGTSVAQAVATVSAAGSGVAAALNDEVVRRSA
                     WDDTPLREADRLEVLTAVQGG"
     gene            16534..17316
                     /locus_tag="GNZ18_RS35410"
                     /old_locus_tag="GNZ18_35430"
     CDS             16534..17316
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573836.1"
                     /locus_tag="GNZ18_RS35410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35430"
                     /product="thiazole synthase"
                     /protein_id="WP_156221011.1"
                     /transl_table=11
                     /translation="MTVQNETDPLEIAGERLDSRLIMGTGGAPSMAVLREALVASGTEL
                     TTVAMRRVDPSARGSVLDVLRECGVRVLPNTAGCFTAGEAVLTAKLAREALGTDWVKLE
                     VIADERTLLPDPIELVEAAEQLVDDGFTVLPYTSDDPVLARRLERIGCAAVMPLGSPIG
                     SGLGIRNPHNIALIVEQAGVPVILDAGIGTASDAALAMELGCDAVLLATAVTRAQSPAR
                     MAAAMRHAVEAGRLARQAGRIPRRHHAQASSPFEGLAT"
     misc_feature    complement(17466..17476)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            17471..18436
                     /locus_tag="GNZ18_RS35415"
                     /old_locus_tag="GNZ18_35435"
     CDS             17471..18436
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658553.1"
                     /locus_tag="GNZ18_RS35415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35435"
                     /product="DMT family transporter"
                     /protein_id="WP_156221012.1"
                     /transl_table=11
                     /translation="MEEGNVPAPARVDRLAVAAATVTVVLWASAFVAIRSAGEDYSPGA
                     LALGRMLSGALVLGAICLVRREGLPSRAAWPGIATAGVLWFGAYMIALNWGERLVDAGT
                     AALVVNIGPILIALLGGWLLKEGFAPRLLAGMAVSFAGAAVVGLSMSDEGGSSVGGVLL
                     CLAAAVTYAAGVVTQKPTLRHATPLQFTTFSCAIGALACLPFAGQLAGEAADASTGATL
                     NVLYLGVFPTALAFTTWGYALARTSAGKMGATTYAAPALVVLMSWLFLGEVPGLLTLAG
                     GVLCLAGVGVSRSTRSPRRGTPVLPAEPEPDPTGAGAGAR"
     gene            18515..20410
                     /gene="pknB"
                     /locus_tag="GNZ18_RS35420"
                     /old_locus_tag="GNZ18_35440"
     CDS             18515..20410
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630843.1"
                     /locus_tag="GNZ18_RS35420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_35440"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_173390991.1"
                     /sec_met_domain="Pkinase (E-value: 9.2e-52, bitscore:
                     169.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDATATDPLVGRVLDGRYRIESRVARGGMATVYVARDIRLDRVIA
                     IKVMHAALAADEDFVARFIGEAKSAAALSHPNVVAVYDQVTDGEHVFLVMEYVEGHTLR
                     DALTAAGRFGPRAALEIMQPVLAALGAAHRAGLVHRDVKPENVLITEDGRVKVADFGLA
                     RAESASKMTRTGVIIGTVGYLAPEQVVAGHVDVRTDVYAAGIMLYELVTGRLPHQADTA
                     FAVAYKHVNETVPPPSEAVPGIPRQVDDLVTDATSHEPDRRPRDANQFLAEVAEAYNGL
                     PRDFDQRMEQPTTTVEMHAPAPHTAVMDRRELPRERGRADRAIGVITGRYVLIAVGAVV
                     AMVLGWAVWYETSGQYDHVPEKIVGMKVADARAKLEGGGLDVRVAKAVYDDRVRKGEVA
                     RSDPPAGARVAKGETVTLTPSRGRSPREVPDVEGKSLADARRILGDKGFTVGQTSTNGS
                     QTVSRDRVISSDPPAGERRSPDEPVDLVISSGMSMPNLVGIGGENAANQLRSMGLDVKI
                     DKRKVDGKPAATVVSQDPPMGTGVSRGDHVTLVVNEDDCKIDIGPVKWGCKQGGEEDIP
                     VPNLMGRNVDEAKAALEDSGFKVTVTGIGGDTVRFQNPSSGEAPRGSTITLLRGP"
     misc_feature    complement(20433..20451)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.19"
                     /tool="antismash"
ORIGIN
        1 ggggatcgcg atccccacca cgccctggtc gcgcagcgcc gacccgagcg agccggtggc
       61 ccgccagttc gaggccacgc gcgcgggctc gcgcaccacg tacccggcga cctggatgcg
      121 gccggactcc ggatcctcgg cgttgacgcc ggtgttgccg atgtgggggg aggtcatcgc
      181 gacgatctgc cgcgcgtagg acgggtcggt cagggtctcc tggtagccgg tcatgccggt
      241 gttgaagacc atctcgccga aggtctcgcc ctcggccccg taggccgtcc cccggaacac
      301 cctgccgtct tccagaacca gcagagcagg ggtcattgga gcttcccttc caggacggtc
      361 ggcgtgccgc gcaggaacgt cgcgacgacc cgtccgggca gcgccagccc cgcgaacggg
      421 gtgttgcggc tcttggaggt catctccgac gcgtccaccg cgcggcgcgg cgacgggtcg
      481 tacagcgtga tgttggcggg cgatcccgcc tccagcggac ggccctgtcc ggagaggcgg
      541 ccgatgcggg cggggctcag cgacatccgc tcggcgaccc cggcccagtc gagcagcccg
      601 gtctcgacca tggcctcctg gacgacgggc agcgccgtct ccaggccgat catgcccatc
      661 gccgccacgg cccactcggt ctccttcgcc tcgaccgggt gcggggcgtg gtcggtggcg
      721 acgcagtcga tcgtcccgtc ggcgagcgcg gcgcgcagcg cggcgacgtc ctcggcggtg
      781 cgcagcggcg ggttgacctt gaagatcggg tcgtaggtgc cggcgcgggt gtcgtccagc
      841 agcaggtggt gcggggtgac ctcggcggtc accgggcagc ccttgctctt ggcccagcgg
      901 atgatctcca cggacccggc cgtggagacg tggcagacgt gcagccgcga cccgacgtgc
      961 tgggcgagca gcacgtccct ggcgatgatc gcctcctcgg ccacggcggg ccagccgcgc
     1021 agcccgagcg cggccgacat ctcgccctcg ttcatctgcg cgccctcggt gagccggggc
     1081 tcctgcgcgt gctgggcgac gacgccgccg aacgccttca cgtactccag cgcccgccgc
     1141 atgatcaccg cgtcggacac gcagtgcccg tcgtcggaga acacccggac ccgcgccgcc
     1201 gagtcggcca tcgcgccgag ctcggcgagc tgctcgcccg cgatgccgcg cgtcacggcc
     1261 ccgacgggct ggacatcgca gtacccggcc tcgcggccga gccgccacac ctgctcgacc
     1321 acgcccgccg tgtcggcgac cgggtcggtg ttggccatcg cgtggacgga ggtgaacccg
     1381 cccatcgcgg cggccttcgt gccggactcg acggtctcgg cgtcctcgcg ccccggctcg
     1441 cgcaggtggg tgtgcaggtc gacgagcccg ggcagcgcga ccaggccgtc ggcgtcgacg
     1501 gcctgcgcgc cgccggcgtc gagcccggtg ccgatctcgg cgatctgccc gttccggacg
     1561 aggatgtcgg cgggcgcgcc gcccaggatg cgcgcgcccc tgatcaggtg gttcattcgg
     1621 tgacctccgt gccgatggcg ggctcggagc ctccgagcag caggtagagc acggccatgc
     1681 gggcgctgac gccgttggcg acctgctcga cgatcgtgga ccggaccgag tcggcgacct
     1741 cggcggcgat ctccacgccg cggttcatcg gccccgggtg catgacgatg gcgtgctcgg
     1801 ggagcgcggc catgcgctcg ccgtccagcc cgtaccggcg gctgtactcg cgcacggtcg
     1861 ggaagtaggc ggcgttcatc cgctcctgct ggacgcgcag catcatgatg acgtcgctct
     1921 tgggcagcac cgcgtcgagg tcgtaggaca cctggcaggg ccaggtgttg atcgcgaccg
     1981 gcagcagcgt gggcggcgcg accacggtca cgtcggcgcc gagcgtcccg agcagcagca
     2041 cgttggagcg tgccacccgg ctgtgcagga cgtcgccgac gatcgtgacc cggcgcccct
     2101 ccaggtcgcc gagccgcttg cgcatcgtga acgcgtccag cagcgcctgg gtggggtgct
     2161 cgtgggtgcc gtccccggcg ttgaccacgc tgccctggac ccagcccgcg agccggtgcg
     2221 gcgcgcccga ggcgccgtgc cggacgacga cgccgtcggc gcccatcgcc tccagcgtca
     2281 gcgcggtgtc cttcaggctc tcgcccttgg acacgctcga ccccttcgcc gagaagttga
     2341 tcacatcggc ggacagccgc ttggcggccg cctcgaagga gatccgggtg cgggtggagt
     2401 cctcgaagaa caggttgacg accgtccggc cgcgcagcgt cggcagcttc ttgatcgagc
     2461 ggcccgcgac cttctccagc tcctcggccg tgtcgaggac gagcagcgcg tcctcgcgcg
     2521 tcaggtcggc cgccgagatc agatggcgct tcaccggtca ccccccgccg gaccgagcag
     2581 caccgcgtcg cgtccgtcgt tctcgcccag caggacccgc acggtctccc gcatcgaggt
     2641 gggcaggttc ttgccgacgt agtccgcgcg gatcggcagc tggcggtgcc cgcggtcgac
     2701 cagcaccgcg agctggacgg cgcggggccg cccgaggtcg ttgagggcgt cgagcgcggc
     2761 gcgcaccgtc cggccggaga acagcacgtc gtcgacgagg acgaccacgc ggtcgtcgac
     2821 gccgtcctgg ggtacctccg tgcggcccag agcgcgcgcg ggacgcatcc ggagatcgtc
     2881 ccggtacatc gtcacgtcca gggaccccca gggcaccggg cggccctcca cgtccccgag
     2941 gaggcccgcc agccgctcgg ccagcgtcac cccgcgggtc tggatgccga ggagcaggac
     3001 gtcgtgcccg cccttggtgc gttcgaggat ctcgtgcgcg atgcgggtca gcgcgcgccg
     3061 gatgtccggt ccctccagaa cggccttggg ccgggggtca ccgtccgcca cgcgcgccgc
     3121 cgccggctcg tccggccggg aggcagcatt caccaccgaa acctcctttc ccgcctcaca
     3181 ggacggggct taaaggacgc cttgtccccc acaccgtagc agccggtacc cacgggtccg
     3241 catcggaccg gtccacgtct tgcctggtga gaggggtcac actcgaacgc gcgcggagcg
     3301 gcccgcggcc ccggcgcggc gcccgcgggg ccgggcccgc cgggcttccg gccgatccgg
     3361 acgaccccca gcgagaccta ctgattcgac cgcttttttc caatcagctt gacctgaggc
     3421 cgtccccgtt ttaccgtcac tgtccgtaac catccccgga ggtggattcc cggagcgatc
     3481 agcgcgccgg gttccccgcc tccgccccgg cgtcccgccg ggggcaaacg acgacgaaag
     3541 tgagcctggg gggccgacaa tgccgtctga atacgctaag gctctcggcg cgcgcctgcg
     3601 cgccatccgc acacagcagg gcctgtccct gcacggtgtg gaggagaagt cccgcggccg
     3661 ctggaaggcc gtcgtcgtgg gttcgtacga gcggggcgac cgcgccgtca ccgttcagaa
     3721 gctggccgag ctcgccgatt tctacggcgt gccggtttcc gagttgctgc ccggcggagc
     3781 cgcgccgagc ccgctcgggc ctacacccaa gctcgtgatc gacctcgagc ggttgcagca
     3841 gcttccgaaa gacaaggccg gtcctctcgc ccgctacgcc gcgacgatcc agagccagcg
     3901 gggcgactac aacggaaagg ttttgtccat ccgccaggaa gacctgcgtt cactcgcggt
     3961 catctacgac aagtccccga acgagctcac ggaagagctc atcacgtggg gcgtcctcga
     4021 cccggaggcg cggcgcgccg tcgagtcgtt ctaaccccta gcaccaccta attctggcac
     4081 caccgaaacg ggggcccggc cgacgccggg cccccgttcc gcgtcccggc ccgaattccg
     4141 ttgcggcggg cgccggcgcg cgcctgcatg cgggccgacg ccggccggac gcggcgcagg
     4201 gcgcgaaacg ggtgcccgcc gcgggaggcg tcccggctct gagggggcgc gtcgaagctc
     4261 tgagggggcg cgtcgaagac cggggccgtg ctccagcggc ggccccggtc ttcgggcgcg
     4321 gccgtcccct ggggaggtct acgggacggc ccgggagtgg ctcagggggt tggcggggtc
     4381 ggtcggcggg gtcggtcggc gggcccgtca gcgaggtcgg ctcgcctcgg agcccgtcgg
     4441 cggggtcagc tcgcctcggg gatcggcaag gtgggctggc tggtcacgcc gagggtgtcc
     4501 tcgacgaggg tgacgaagac ctcggcgtcg tgcagcagct cctcggcctc gcgcggcgtc
     4561 accgcgcgcg gcaggcccgc ctcggcggcg gcgcgcttgt cggcgccggc ggcgaagaac
     4621 gcggcccact cgcgcagcgc gggctcggcc tcgggcagca gcacccagac gctgcggggg
     4681 cgcccccgcc ggtgcgtctc cagcggttcc ttggacgcca gcaccgcggc ggcggcgcgc
     4741 agcgcggcca ggtgggcgca gacgtagcgg acggcgggcg aggtggcctc ggccgcctcg
     4801 gcgaggccca tgcgggcggc gtggagctgg ccgaccgccg tgtgcgccgg acgcggcgcg
     4861 ggcttcggcc gcgagcgcgg gcccggcggg ccgaactgcg cggcggaatg aactccgcgg
     4921 gcggtcgtcg tttcggacat gactgcctcc ttccggggct cgggccggcc gggcggagag
     4981 cttcccctca ctccgcccgg ccgtccgtcc cgcccggggg catcgcgctg ccgccgggcg
     5041 gggacgtcgc cctggcgcgg gccgcgagtc ccgcgccacg tcgaacataa gttcgacgca
     5101 ctcacagtaa agcgttcccg gggcgattcg tcaacgtgtt cgaacgggtg gcgcttccca
     5161 caggtcagcg ggttacacga accacctgac cacccgtcat cccaggcgtc ggacgtgcac
     5221 ggccacaccc gtcccgacca ggctcgggaa gtactccgcg atgtgcatgg gcagccggac
     5281 gcagccgtgc gaggccgggt accggggcac gtcgagggcc ccgtggaagg cgatgccgcc
     5341 gttgaagtag acggggttgt agagccgtcc gaggggcgag acctcccagc ccttggcgcg
     5401 gcggcccgtc cggaagtcgc cggtgcccgt cgtggcgtag cggcagcggg cgacggtggc
     5461 gccccggtcc ttggcgcagt agtactcccc cgagccggac gacacgtgcg tgatgagccg
     5521 gggcctgccg tccctgtaga ggacgaggta ctggcggcgc aggtccacgt cgacccggtc
     5581 ggcctcgtgg cgcctggcca tcgggcgggg ctcgcggggg cggtccagcg ccttccagaa
     5641 gggcgcgccc agcgtcccgg actgcttgag ccggttgacg gcctggaacg cccacacggc
     5701 gagctgggtg gacgtcccgt actccccgtc caccacgccc gggtcgtagt gcaggccctt
     5761 caggcggcgc tggagctccc ggacgtcggc cccctccgct ccgggcctca gtttgcggtc
     5821 cccggcccgg agcgggggca cgggcctgga cggcgacggc ttgggcgtgg ccctggccct
     5881 cggcttgcgg acgggctccc gcttgggctt gtgcttgggc ctgtccgccg acggcttgtg
     5941 gggccgcgag gagcgccccg cgtcggcggg ggccgcctcg cccgccgtct tgcaccccgc
     6001 cagcaggacg atcgggatca gcaacgccgc gcttttccgc atgcccatgg tctcctccgc
     6061 ctcaccgctg accttaaagt gcttcccatg cacgcaaatg ccgaacgtgt cgcacgggcc
     6121 ctggaggcgc aaggggcgac ggggaagatc gtggagctgc ccgactcggc ccggacggcg
     6181 caggccgccg ccgaccagct cggatgcgag gtcggcgcga tcgccaacag cctggtgttc
     6241 gacgccgacg gggcgccgct gctggtgctg accagcggcg cgcaccgggt cgacacggcg
     6301 cgggtcgcgg cgctggtggg cgcggaggcg gtgcgccggg cgacgccgga gttcgtccgg
     6361 gacgcgacgg gccagcccat cgggggtgtc gccccgctgg gccaccccgc gccgatccgc
     6421 acgctcgtgg acgtctggct ggacaagtac gacgaggtct gggcggccgg cgggcacccg
     6481 cacaccgtgt tccccacctc gtacgaggaa ctgctgaaaa tcaccggggg caccccggcg
     6541 gaggtgggct gagatgggcg acgacgcgca gggtgacgcg cggggtacgg aactgtggca
     6601 caacccgcgc tgctccaaga gccgcgccgc gaaggccgcg ctggacgagg cgggcgtccc
     6661 ctacaccgag cgccgctacc tcgacgagcc gcccacggcg gcggagctgg acgcggcgct
     6721 gaccaggatc ggcgccgagc cctgggacgt cgcgcggctc aacgagcccg tcgccaagga
     6781 gctcggcctg cggtccctgg agcacgaccg ggcgcgctgg atcgagatca tggtggcgaa
     6841 cccggtgctg atccagcggc cgatcgtcct gacccgggcg gtggcggtgg tggcgcgcga
     6901 cggggaatcg ctgcgccggg ccctcgacag ccggtgaccc tgatgtgatt ctggtggcca
     6961 ggatgtgatc ctgggggacc gagcaacgac gatcggtgac caaccggagg ggcgatgacc
     7021 gcgcagatgc gctccggccc ggcggcgcgc gacccggagt tccgggggat cgacccgccc
     7081 gcgctcgacc gggtgatccg ccagctccag gacgcgcaga acgcgatcca gggctggctg
     7141 aacgggcacc gccccccgcc gggggtgccc gcgaccgggt accggcaggc cgaccaggtc
     7201 gcgctgtggg ccgccgacca gctcggcatg ctgacccgcc gctacaacta cgcgatcacg
     7261 cacccggacg gcggcggcgt cgacgtcccg cccgtccacg cgccgagccc gaagccgagc
     7321 cccggcggga acccgggcgc gggcggcggc gtgcagcccg gcaggccggg cgcgaccgcg
     7381 ccgcgcacgc cctcgcccgg cacgccgggt acgccggggc ggcgccatcc ggtgcgcccg
     7441 ccgaggcaca cggcgccgcc gacctcgcgg ggcgcgggcg acctcggcaa cttcccgacc
     7501 cggcaggcgg cggcgcgggc cgcgcgggcc gacgcgctgg ccgtggccgc cgccgtccgc
     7561 gacggcgacc ccgtgccgga cggcgtgtgg aagcacctgc gggccaacgc cgacgacccc
     7621 gactacaccg aggcgctgta cgagcggctc ggccccgcct ccgcggcggc cctggtgaag
     7681 gccgcccacg gcgacgcggc gctgctgcag gccctgcggc aggcgctcgg cacctccagc
     7741 caccacctgg cgatggacac ggcgtggctg cgcgcgttcc tcgccgaggc cgaccgggag
     7801 ggcgtgcggc cggtcgccgt ccaggtgctc accggcgccg atctgagccc ccggacccgc
     7861 gacgcgctcg ccgggctgca ccagaaggcg ggtggctgag cgtgtcctcc ccctcgtccg
     7921 ccccgccgcc gcccgggagc ctgccgccgc cgatcgaggc cgcggcggcg gtgggcctgc
     7981 cgccgaccga gcgcccgaac cccgagtacg ggcagctgta ccaggcgtac gcggacgcct
     8041 acggcagcat cgaccggctc cggcgggcgc tcgacgcctc cgcccgcacg ctcggctcga
     8101 ccgacgcctg gctcggcccg gaggcgcgcc agtggggcgg gcagctcgac gccaaccgga
     8161 acgcgctgcg caaggcggcc gaccgcatcc tgtgggacat ctacgaccgg ctcaacgcga
     8221 cccagcgcac catcgccaag ctctgatccc cctcccccgg gccgcctccg tcaccgcgcc
     8281 cgcggccgcg ccggatcacc gttcccggag cgggtgagcg ggcgggacgt ctagtctctg
     8341 tctggtgagg gacgtccggt gagggatccg aagctgcgcg agatcgacga gcgcgccttc
     8401 ctgcgccggc tcggcccgat gctggaggtg tacgccgcga cgatggcgcc gcccgccgag
     8461 cagctccccg gccgccacac gatcatggag cggcacgcgg cctaccccgg gttccgcgcg
     8521 ttcgtcgcgg agcggcgcgg gccgctgccc ggcctggccg ggccggtgca ggggttcgcc
     8581 tacgggttcc acggctcgcg cgggcagtgg tggcacgaca tcgtccacca ggcgctcgcc
     8641 gcgcgggagg ggcccgagca cgcggacgcc tggatggacg acccgttcga ggtggcggag
     8701 ctgcacgtcc acccggcggc gcagggcaag ggcctcggcc gggggctgct gaccgcgctg
     8761 tgcgagggca ggccggagcg gacggtggtg ctgtccacgc tggacctgcg gtccgccacc
     8821 ccggcccaac ggctctaccg gtcggtgggc atggtcgacc tgctgacggg gttcgagttc
     8881 cccggcggcg ggccgctcta cgcggtcatg ggcgggacgc tgcccctggc gccgtacccg
     8941 tcggcctcca gcagcccgta gacctcgcgg gtcgccgtcg acttgttgaa ggtgatgaag
     9001 tggatgccgg gcacgccctg gtcgagcagg tcgcggcaca gctgcgccgc gtgctcgatg
     9061 ccgaggcgcc ggacggcctc cgggtcgtcg gcgacggcct cgaaccgggc gcgcacgtcc
     9121 gcggggaagg gcgcccccga gagctgctcg gaccggtcga tcgtgctgat ctgggtgacc
     9181 ggcatgatgc ccgggatgat cggcacgtcg cagcccgcgg cgtcgacgcg gtcgcgcagg
     9241 cgcaggaagt cgtccgcgcg gaagaacatc tgggtgatgg cgtagtcggc gccggcgcgg
     9301 cacttggcga cgaagtgccg ggtgtcgctc tcgatgtcgg gcgagcgcgg gtgcttgtag
     9361 gggaatgcgg cgacgccgac gctgaagtcg ccgtaggagc ggatcatccg gacgaggtcg
     9421 gcggcgtact cgacgccgtc ggggtgcttg acccactccc ccatcgggtc gccgggcggg
     9481 tcgccgcgca cggcgaggat gttgcgcacg ccgaccgccg cgaaccggcc gatgagctgg
     9541 cgcagctccg cctgcgagtg gtcgacggcg gtgaagtgcg cgacgggcgt gagcgtggtg
     9601 tcggtcgcga tccgctcgac gatgtcgacg gtcttgtcgc gggtgccgcc gcccgcgccg
     9661 taggtcaccg agacaaacga cgggtggagg ggctccagct cgcggatcgt ccgccacagg
     9721 ttccgcgcgc ccttctcggt cttgggcggg aagaactcga aggagaagga cctgcccgag
     9781 gccaggagtt ctcggacggt cgggggccgg tctgggcgca ggcgtcgcat caccccagag
     9841 tacagaagcg gccttgagcc gaaggtgaac ggcggacggg cccgggtgga gtgatccctc
     9901 ccacctcgcg ccatccggta tgcaccttaa atagctagaa ctgggcattt atcccgttat
     9961 gacgtacgag cggccaccga ctcctggata cgatctcggc atgtcatcga gccccatccg
    10021 caaggaggtc gacggggcgc tgctggcctt cgtcgcccgg cagcgtccga acctgctggc
    10081 gatcagcgac gagctggccc cgctgatggc cgcgctggac gcgctgctcg cggagggcaa
    10141 gcggctgcgg ccggcgttct gctactgggg ctggcgcgcg gcgggcgccg tggaggagga
    10201 cctcgacggg ccgcccggcg agcggctgca cgaggggatc gtcaacgcgg cggcgtcgct
    10261 ggagctgctc caggcgagcg cgctgatcca cgacgacgtg atggactcca gcgacacccg
    10321 ccgcgggcag ccctcgatgc accgcaggtt cgaggcgctg caccgcgcgc agggctggcc
    10381 gggccccgcg cgggcgttcg gcgagggcac cgcgatcctg ctcggcgacc tgtgcctcgc
    10441 ctggtcgggc gagatgttcg agacgtgcgg gctggacgag gagcgccgcc gccggggccg
    10501 cgccgtctac gacctgatgc gcaccgaggt catgtgcggc cagtacctgg acatgctgga
    10561 gggcacccgg ggcgaggccg ccgtcgacac ggcgctgcgc gtggtggagt tcaagagcgc
    10621 caagtacacg atcgagcggc cgctgcacct cggcgccgcg ctcgccgggg gcgccccgga
    10681 ggtgtcggcc gccctcaccg gctacggcgt cccgctcggc atcgccttcc agctccgcga
    10741 cgacgtgctc ggcgtgttcg gcgacccggc cgagaccggc aagcccgcgg gcgacgacct
    10801 gcgcgagggc aagcgcaccg tcctggtcgc gctgaccctc gaacgcgcca cgcccgcgca
    10861 ggcggcggcg ctccagcggc gcctcggcga ccccggcctc gaccggccgg gcgtggacga
    10921 gctgcgccag atcatcaccg acaccggggg gctcgcggcc tgcgaggcga tgatcgcccg
    10981 ctacaccggc gacgccgagc gcgtgctggc ggccgcgccc gtcccggagg aggcccgcgc
    11041 cgcgctgaac gccctcgccg tcgccgcgac cgcgcgccgc acctgaccgc gcggcgcgct
    11101 ccggggaccc gaagatcggg gttcccctgc cgactcccgt gatgacgcgg tacaaatgag
    11161 gaaatcttcg tccgtccccg ccgagtcgga gtccgccgtg ccgcacgaca cctcccgcgg
    11221 gagggcgaac ccccatcacc cgcgtcccgc cgcccgatcc gccggcggcg ccccgccgcg
    11281 cgccggtcag ccgcgcggcg gcaagccccg cgccgcggag ccgcaccccc gcgcggccag
    11341 gcccgcgcgg ccccggcacc ccggttcgcc gctctgggcg ggcgacccgg gctccctcgg
    11401 cggctacacg ctgctcgggc ggctcggcga gggcggccag ggcgtcgtct acctcggcga
    11461 ggacggggac ggcgcgctcg tcaccgtcaa gctgctgcgc ggcggcgtcg cggccgggca
    11521 gcgcgcccgg ggccgcttcg tcaaggaggc ggacgcggcg cgccgggtcg agggccgcca
    11581 caccgcccgc gtgctggacg ccgacgtcac cggcgaccgc ccctacatcg tcagcgagta
    11641 cgtcgagggg ccctcgctcc agcaggtcgt cgaggaccgg ggcccgctgc ccgcgccccg
    11701 gctccacaag atcgccctgc gcacggcggg cgcgctcgcc gcgatccacc gcgccgagat
    11761 cgtgcaccgc gacttcaagc ccggcaacgt cctgctcggc ccggacggcg ccaaggtgat
    11821 cgacttcggg atcgcgcgca ccgccgacgc gaccccggtg accacgggcc cggtcggcac
    11881 ccccgcctac atggcgcccg agcagatcga ggacgagccg gtcggcccgc ccgcggacgt
    11941 gttcgcctgg ggcgcgacgc tggtgttcgc cgcgaccggg cgcccgccgt tcggcaccgg
    12001 gccgagcgcc gccgtcatgc ggcgcgtgac gtcccggccg ccggacctcg gcgagctgga
    12061 gggcccgctg cgcgagctgg cggcgcgctg cctggacaag aaccccgccg cgcggccgac
    12121 cgcgcggcag ctcgtccgcg cgctgcggga cgggcaggcg cccgcggcca agccgcgccc
    12181 caagcgcatc ccccgctacc ggtggcggat gatggtcgcg ctcgcggtcg tggtcaccgc
    12241 cggcttcgcg ctcggcgtgc tgttctaggt caccagtgcg gcggccgctc ctccagcagg
    12301 cggtcgtcgt cgctcacgcc gccgcgccac tcgccccacc cggtgtcggt gtcgtcggac
    12361 gtctggtcgg gcagcacgtc caggtcgtcg tcgtccaggt gcacgagcct gtcgtcgtcg
    12421 ggtcccatga tcccattgtc ggtcatccgg gccgctgccc cggccgcgcg cgggcgaacg
    12481 gcacccgacg agcgggcatc ggccgggtgg gcgccaagcg gacggaacct gaacggaagg
    12541 cggtcaggcg ggcgggaggc ggtcggcgaa cgcggcggcg gccgcgcccg ggtcgtccgc
    12601 ctcggtgatc gcccggacca ccacgacgcg gcgcgccccc gccgcgagga cctcgtcgag
    12661 gttgccgagg tcgatgccgc cgatcgcgaa ccacggacgg ctcccgcgcc gcccggcgac
    12721 ccgctccagc agctcggggc cgggcgcggc gcgccccggc ttggtgggcg tgggccagac
    12781 cggccccgcg cagaagtagt cgacgcccgc ctgcgccgcc gccgcgcccg cctgcccgtc
    12841 cgagtgcgtc gagcggccga tcaggacgtc ctcgccgatg atcgcgcggg cggccggcac
    12901 gggcaggtcg tcctgcccga ggtgcaggac gtcggccccg gcggcgcgcg cgatgtccgc
    12961 ccggtcgttc accgccatca gcgcgccgtg ccggtcgcac gcggcgcgga acacctccag
    13021 gtactccagc tcctgccggg cctccaggcc cttctggcgg agctggacga ggtcgacgcc
    13081 gcccgcgagc accgcgtcca ggaactcggg caggtcgccc tgccgctccc gcgcgtccgt
    13141 gcagaggtag aggcgggcgc gggagagccg ggcgcggagc gcgacgccct gctcggtggg
    13201 catgtgcgcg gagacggtgc tggccacggt gtcggacggt tccttccgga gacggatcgc
    13261 gggggcacgc ggcggcgccg cggcaccgcg cgtgaccccg caatcgtgtc acgtgtgttc
    13321 gccgggccct cggtccggcc cgtccgaccg ccccgcccta gaaggcgagg gcctgggcgc
    13381 ggcggcgcac ctcggtgccc cggttctcgc tcagcgcctc gacgggcgtg cccggcagcg
    13441 tgtcgtcggc ggtgaacagc cagcggaccg tctccacctc gtcgaagccc gcgtccgaca
    13501 ggagcgtcag cgtcccggcc aggcccttga tgacctggcc gtccttgagg aacgcggcgg
    13561 gcaccatcgg ctcgccggcg cgccggatcg ccaggagccg gcgctcgctg atgagctgct
    13621 tgatccggtt ggtcttgatg ccgaggcggt cggcggtctc cctgagggag agccactccc
    13681 cggccagggc gtcggtgcgg gggtcgagtg cgctgtcaac ggtcgcgtgc atctgcgtca
    13741 cgccccctgc ctaccacgcc ttcggaagac tcaaacccgt tcggcgcccg ttcgcgcagg
    13801 tcagtgtccg ctacgcgcga acagcctgcc ggacgggcac gcccggatcg gccagcgcgg
    13861 cggggtcgac gggggtcccg gcggcgatca cccgcctggc ctgcacgagg tcgcgggggc
    13921 ggccgacggc gaggatcgcg tcgagccggt cgccggtgag ccagacgacc gcccacgccg
    13981 cctccgccgg gtcgccccgg cggacgagcc gctcggacgc cccgtgcacg cccgcgtact
    14041 ggaccatccg gccgaactgc tccgaccaga agtaggggac ggcgtcgtac gccgcgtccc
    14101 ggccgaggag cgcggcggcg gccacggcgg gcgcgttcag ggcggtgtcc cagtgctcga
    14161 cgagcagccg ccgcccgtac cgggcggacc accaggcggc gcagtctccc accgccacca
    14221 cgtcgggacg cggcgccccg tccgccccgg tggcgcggaa cgaggcgtcg gtgacgacac
    14281 cgcgctccag cagcagcccg gatccctcaa gccagcccag gacgggccgg acgccgacgc
    14341 cgacgaccac ctcgtcggcg tcgatccgct cgccgcccgc cagggcgagg ccgccgtcct
    14401 cgaccgccgc gaccttgacg ccggtgcgca gcccgacgcc cgcctcggcg taccagcgcg
    14461 cggtcagcgc gccgacctcg ggcccgagcg cggacgcgag cggggcctcc gcagcctcga
    14521 ccacggtgac cgcgcagccc ttggcggcgg cggccgtcgc gacctccgcg ccgatccagc
    14581 ccgcgccgac gatcgcgagc cgggtgccgg ggacgagcgc ggcgcgcagg tccagggcgt
    14641 cctcgacggt gcgcagcacg cgctggcgcc cgccgcccgg cagcgtcacc ggcgcggcgc
    14701 cggtggcgat cacgagcccg tcgaagcgca gctcgcccgc cgtggaggcg agcgcgccgc
    14761 ccgcgcccgg cgcgtccagc cgcaggccgg tggcgcgctc gccgagcagg acctcgcagc
    14821 gcagcgcgtc ccagtcggcc tccagcgtgg tgtcgtcggc ggcgcccgcg aggacgtcct
    14881 tcgacagcgg cgggcggtcg tagggcaggt gccgctcggc ggagacgagg gtgatcgcgc
    14941 ccgtgtggcc gccctcgcgc agcccctgcg ccgcccgcag tcccgccagc ccgccgccga
    15001 cgacgatcac gctgtccatg gccgtccacc ctagccgggg gacctccgga cacagtgatc
    15061 ggtatccgga catcggcgca tatcgccagg ggtcgtatgg tggggggcga gagcgcggga
    15121 gtccggtgcg accgggctga gagggcggct gaacgggccg ccgaccgcta cgacctgatc
    15181 cggatcatgc cggcgaaggg agcgcgcatg gagatcgtca tcctcggcgc cggaatcatc
    15241 ggcctcgcca ccgcctggcg ggccgccgcg ggcggcgccg ccgtcacgct cgtcgacccg
    15301 gcgcccatga gcggggcgac ctcggtcgcg gcgggcatgc tgaccccggt cagcgagctg
    15361 acctacggcg aggagccgct gctgcggctc ggcctggcct cccgcgaccg ctacggcgcg
    15421 ttcgtcgccg agctggagga gcggaccggg ctcgacgtcg cccaccgcac cgacgggatc
    15481 ctggaggtcg cgttcgactc cggcgacctg aaccacctgg acgacctccg ccgcttccag
    15541 gagagcctcg gcatcccgac cgaggcgctg accggccgcg agtgccgccg gcacgagccg
    15601 atgctggcgc ccggcgtgcg cggcggcctg ctcgcccccg aggacggctc gatcgacccg
    15661 cgccgcctcg cccccgccct gctggcggcg gccgagggcc tgggcgcgcg gctcgtccgg
    15721 cggcgggcgg cgggagtcct ggtcgagcgc gaccgggccg ccggcgtccg cctcgacgac
    15781 gggaccgaga tccgcgccga ccgcgtgctg ctcgccgccg gctcctggtc cggcgacctg
    15841 gaggggttgt cggcgggggt ggtcccgccc gtccgcccgg tgaagggcca ggtcatccgg
    15901 ctgcggacgg cggtgccgtt cctgcgccgc tccacccgcg cgctggtgcg cggctcgtcg
    15961 gtctacctcg tgccgcgcgc ggacggcgag atcgtcgtcg gcgcgaccca ggaggagctg
    16021 ggcttcgaca cgcgggtcac cgcgggcggc gtgtgggagc tgctgcgcga cgcccacgag
    16081 ctgctcccgg gcatcaccga gctggagttc gccgaggtct cggcggggct gcggcccggc
    16141 tcgcccgaca acgcgccggt gatgggcccg tcggcgctgc ccggcctgtt cctcggcacc
    16201 ggccacttcc gcaacggcat cctgctcgcc ccggtcagcg ccgacatcct ggccgcgatg
    16261 ctgctggacg ggcccgtccc cgccgaggcc gcccccttca cccccgaccg cttctccccc
    16321 gaggtgcact gatgaaggtc atcgtcaacg gcgagccgcg cgaggtgccg gagggcacca
    16381 gcgtcgcgca ggccgtcgcc accgtctccg cggccgggtc cggcgtcgcc gccgcgctca
    16441 acgacgaggt cgtccgccgg tcggcgtggg acgacacgcc gctgcgcgag gccgaccgcc
    16501 tcgaagtgct caccgccgtc cagggaggct gacatgaccg tccagaacga gaccgacccg
    16561 ctggagatcg cgggcgagag gctcgactcc cggctcatca tgggcaccgg cggcgcgccc
    16621 agcatggcgg tgctgcgcga ggcgctcgtc gcgtccggga cggagctgac cacggtcgcg
    16681 atgcggcggg tcgacccgtc cgcgcggggc tcggtgctgg acgtgctgcg cgagtgcggc
    16741 gtccgggtgc tgccgaacac ggcgggctgc ttcacggcgg gcgaggccgt gctgaccgcc
    16801 aagctcgcgc gcgaggcgct cggcaccgac tgggtcaagc tggaggtgat cgccgacgag
    16861 cggacgctgc tgcccgaccc gatcgaactg gtcgaggccg ccgagcagct cgtcgacgac
    16921 ggcttcaccg tgctgcccta caccagcgac gaccccgtcc tcgcacggcg gctggagcgg
    16981 atcggatgcg cggcggtgat gccgctcggc tccccgatcg gctcggggct cggcatccgc
    17041 aacccgcaca acatcgcgct gatcgtcgag caggccgggg tcccggtgat cctggacgcg
    17101 gggatcggca ccgccagcga cgccgccctc gccatggaac tgggctgcga cgccgtcctc
    17161 ctcgccaccg ccgtgacccg cgcccagtcc cccgcgcgga tggccgccgc gatgcggcac
    17221 gccgtcgagg ccggacgcct cgcccggcag gcgggacgca tcccgaggcg ccaccacgcc
    17281 caggcgtcct cccccttcga gggcctcgcc acctgatgta gagatcctta aagatcgcct
    17341 gtagcaggat tcgctggacc cgcacgtcaa ccgcaccgag actggatcta tccccccgaa
    17401 cccccccgtc ccgcaaccat gcgcgacatt tcggtgttga tggaagcatt ccagacctaa
    17461 ggtgcgtgac atggaagaag ggaacgttcc cgccccggcg cgcgtcgacc ggctcgcggt
    17521 ggccgccgcg accgtgaccg tcgtcctgtg ggcgtcggcc ttcgtcgcga tccgcagcgc
    17581 cggggaggac tacagccccg gcgccctcgc gctcggccgc atgctctccg gggcgctcgt
    17641 gctcggcgcg atctgcctcg tccgccggga gggcctgccc tcccgggccg cctggcccgg
    17701 catcgccacc gccggggtgc tgtggttcgg cgcctacatg atcgcgctga actggggtga
    17761 gcggctcgtg gacgcgggca ccgccgcgct cgtcgtcaac atcgggccga tcctcatcgc
    17821 gctcctcggc ggctggctgc tgaaggaggg cttcgcgccc cggctcctgg cgggcatggc
    17881 ggtctcgttc gcgggcgccg ccgtcgtcgg gctgtcgatg tcggacgagg gcggatcctc
    17941 ggtcggcggc gtcctgctgt gcctggccgc cgccgtcacc tacgccgcgg gcgtcgtcac
    18001 ccagaagccc acgctcaggc acgccacgcc gttgcagttc accacgttct cctgcgcgat
    18061 cggcgccctc gcctgcctgc cgttcgccgg gcagctcgcc ggagaggccg ccgacgcctc
    18121 caccggcgcg acgctcaacg tgctctacct gggcgtcttc ccgaccgcgc tggcgttcac
    18181 gacctggggg tacgcgctgg cccgcacgtc cgcggggaag atgggcgcca ccacctacgc
    18241 cgcgcccgcg ctggtcgtcc tgatgtcgtg gctgttcctg ggcgaggtcc ccgggctgct
    18301 cacgctcgcg ggcggcgtgc tgtgcctggc cggtgtcggc gtgtcccgca gcacccggtc
    18361 gccgcgccgc ggcacccccg tcctgccggc cgaacccgag ccggacccga ccggcgccgg
    18421 cgccggcgcc cggtgaggct ccgacccgcg gcgcaggggc gctcatactc gggactgatg
    18481 agatccgccc ggacgtcgcc gtaaactcgc agcgatggac gcgacggcta ccgatcccct
    18541 cgtcgggcgg gtactcgacg ggcgataccg cattgagtca cgggtcgccc gcggtggcat
    18601 ggccaccgtg tacgtcgcgc gcgacatccg cctcgaccgc gtcatcgcga tcaaggtgat
    18661 gcacgccgcg ctcgccgccg acgaggactt cgtcgcccgc ttcatcggcg aggccaagtc
    18721 cgccgccgcg ctctcgcacc cgaacgtcgt cgccgtctac gaccaggtca ccgacggcga
    18781 gcacgtgttc ctcgtgatgg agtacgtgga gggccacacg ctccgcgacg cgctcaccgc
    18841 cgccggccgg ttcggccccc gcgccgcgct ggagatcatg cagccggtgc tcgccgcgct
    18901 cggcgccgcg caccgggccg ggctggtgca ccgcgacgtc aagccggaga acgtgctgat
    18961 caccgaggac ggccgggtca aggtcgccga cttcggcctc gcccgcgccg agtccgcgag
    19021 caagatgacc cgcaccggcg tgatcatcgg aaccgtcggc tacctggcgc ccgagcaggt
    19081 ggtggcgggg cacgtcgacg tccgcaccga cgtctacgcc gccgggatca tgctctacga
    19141 gctggtcacc gggcggctgc cccatcaggc cgacaccgcg ttcgccgtcg cctacaagca
    19201 cgtcaacgag accgtcccgc cgccctcgga ggccgtcccc ggcatccccc ggcaggtcga
    19261 cgacctggtc accgacgcca ccagccacga gcccgaccgc cgcccccggg acgcgaacca
    19321 gttcctcgcc gaggtcgccg aggcctacaa cggcctcccc cgcgacttcg accagcgcat
    19381 ggagcagccg accaccaccg tcgagatgca cgccccggcg ccgcacacgg ccgtcatgga
    19441 ccggcgggag ctgccccgcg agcgcggccg cgccgaccgc gcgatcggcg tgatcaccgg
    19501 ccgctacgtc ctgatcgcgg tcggcgcggt cgtcgcgatg gtcctcggct gggccgtctg
    19561 gtacgagacg tccggccagt acgaccacgt ccccgagaag atcgtcggga tgaaggtcgc
    19621 ggacgcccgc gccaagctgg agggcggcgg cctcgacgtc cgcgtcgcga aggccgtcta
    19681 cgacgaccgc gtccgcaagg gcgaggtcgc caggtccgac ccgcccgcgg gcgcccgcgt
    19741 cgccaagggc gagaccgtca cgctcacccc gtcccggggc cgctccccgc gcgaggtccc
    19801 ggacgtcgag ggcaagtccc tggccgacgc ccggagaata ctcggcgaca agggcttcac
    19861 cgtcgggcag accagcacca acggctcgca gaccgtctcc agggaccggg tcatcagcag
    19921 cgacccgccc gcgggcgagc ggcgctcccc cgacgagccg gtcgacctcg tcatcagcag
    19981 cggcatgtcg atgccgaacc tggtcggcat cggcggcgag aacgccgcca accagctccg
    20041 ctcgatgggc ctggacgtca agatcgacaa gcggaaggtg gacggcaagc cggcggccac
    20101 ggtggtcagc caggacccgc ccatgggcac cggcgtgtcg cggggcgacc acgtcacgct
    20161 cgtcgtcaac gaggacgact gcaagatcga catcggcccg gtcaagtggg gctgcaagca
    20221 gggcggcgag gaggacatcc ccgtccccaa cctgatgggc cgcaacgtcg acgaggccaa
    20281 ggcggccctg gaggactcgg gtttcaaggt caccgtgacc gggatcggcg gcgacaccgt
    20341 ccgcttccag aacccgagct ccggcgaggc cccccgcggc tccaccatca ccctcctccg
    20401 cggcccctga gccgtcccgg cccaacgcgc ccgttgaggc cacttcgcaa cacgccatag
    20461 gctggacgac ctatgacctc accgaagagc ctgatcggcg cgcacgtccc ggtcgccggc
    20521 ggtctcgcca ccggcggcct gaagtacgcc gccgagatcg gcgccgagac catccaggtg
    20581 ttcgtggcga acccgcgcgg ctgggcgatg cccgagggca agcccgccga ggacgcgaag
    20641 ctgctggagc gcgccgacgt ccccgtctac gtccacgccc cctacctggt caacatcggc
    20701 tccccgaacc ccgagaccct gaccaagtcg ctggcgagca tccgccactc cctcgcccgg
    20761 ggccgcgcga tcggcgcccg cggcgtcgtc gtccacaccg gctcctccgt gagccagacc
    20821 tacgacgagg cgatggcgca ggtccacgag cacgtcctcc ccctcctcga agagatcccc
    20881 gaggacggcc ccgacctgct gctggagccg atggcgggcc agaacaacat gctctgcgcc
    20941 aaggtccagg aactcggccc cttcttcgac aggctcgaac accacccgaa gctcggcgtc
    21001 tgcttcgaca cctgccacgc ctacgcggcg ggccacgacc tggccgcccc cggcggcgcc
    21061 aaggccgcca tcgacgccct ggtcgc
//
