LOCUS       NZ_WOFH01000007        22565 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Actinomadura litoris strain NEAU-AAG5 Scaffold7, whole genome
            shotgun sequence.
ACCESSION   NZ_WOFH01000007
VERSION     NZ_WOFH01000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura litoris
  ORGANISM  Actinomadura litoris
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 452402)
  AUTHORS   Cao,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2019) Northeast Agricultural University, College
            of Life Science, No. 600 Changjiang Road, Harbin, Hei Longjiang
            150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 109x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009733595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 03:46:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,194
            CDSs (total)                      :: 8,115
            Genes (coding)                    :: 8,044
            CDSs (with protein)               :: 8,044
            Genes (RNA)                       :: 79
            rRNAs                             :: 5, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 1 (5S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 14 of 71
            Pseudo Genes (incomplete)         :: 60 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:00:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 344734
            Orig. end                         :: 367299
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WOFH01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22565
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="5"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22565
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22565
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12565](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12565
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(754..1239)
                     /locus_tag="GNZ18_RS21955"
                     /old_locus_tag="GNZ18_21960"
     CDS             complement(754..1239)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS21955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GNZ18_21960"
                     /product="hypothetical protein"
                     /protein_id="WP_156218385.1"
                     /transl_table=11
                     /translation="MIWVRPALGLLSAAVLVPAVAIVGYGAVEGVSVPLTMSTVSATSA
                     QRNGRGAARGNRGLRYAKTLRGQGVSHGTVTVGARGVVVRGTHRDLRCEDGPSYLKITV
                     VLAGLPDAEHAAGLACGQTREVAFAYAWTGASSAVHLQVCGRRRDACGGRSTVLRPG"
     gene            complement(1352..1927)
                     /locus_tag="GNZ18_RS21960"
                     /old_locus_tag="GNZ18_21965"
     CDS             complement(1352..1927)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545255.1"
                     /locus_tag="GNZ18_RS21960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_21965"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_156218386.1"
                     /transl_table=11
                     /translation="MRKLVYYVGTSLDGFIAGPGGEIDFLPVSDQVMAWIGEHYPETLP
                     THVRPHLGIQDAPNQRFDTLVMGLGTYRPALDIGVTSPYAHVRQYVASTTLPEIADPAV
                     TLVRDPLELARSLKAEDGGMDVWLAGGGRLAAALLPEIDEMIVKSYPVVAGAGVPAFAG
                     GFRPTRFTPTAREEFDNGTQVTWLTRTP"
     gene            1997..2581
                     /locus_tag="GNZ18_RS21965"
                     /old_locus_tag="GNZ18_21970"
     CDS             1997..2581
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017617723.1"
                     /locus_tag="GNZ18_RS21965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_21970"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_242887301.1"
                     /transl_table=11
                     /translation="MRKNVERRAALVDAAIEVLARDGARGLTFRAVDAEAGVPVGTASN
                     YFAKRDDLFTQAGGRIYERLQPDAATLGGMLEGPRDLARVTALLTETVGRISAFRTGYL
                     ALLELRLEATRRPGLRAVLTERVREDVEANVARHLESGMPGDATTVRLLYLTLNWLIVE
                     NLTLPEVFTEEDVRRLVADAVERSLPRQDPR"
     gene            complement(2578..3624)
                     /locus_tag="GNZ18_RS21970"
                     /old_locus_tag="GNZ18_21975"
     CDS             complement(2578..3624)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630638.1"
                     /locus_tag="GNZ18_RS21970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_21975"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_156218388.1"
                     /transl_table=11
                     /translation="MTGPGSWARWARGRFGERGLALTALVALLALAVVPLVALPAVRCE
                     VFGSGCRTPPPEVRADPVSAPGRQFTPVEAATRGGYVALGDSYSSGVGAEATVGDNNPL
                     ERCHRTSKAYYNEVSKAFPFAKGTSFWACSGATTADIRDGRHGEPSQLGRLNADTSLVT
                     LSVGGNDIGFSKVVAGCVVKLPWSRSCFRQGDDIARKMSDLRRNLPELIGQIHARAPHA
                     RIILMGYPKAFSEVEGTGGDNLRVSEQQWLNARAYDLGRLIRETAAEADRRIAARHQQG
                     SVEFVDSYSAFAGHEVGSGQPYMNGLTVNLSALEAEPRSYHPTVSGQHALAGLFIEQVK
                     KGPGRPVS"
     gene            complement(3770..4267)
                     /locus_tag="GNZ18_RS21975"
                     /old_locus_tag="GNZ18_21980"
     CDS             complement(3770..4267)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630640.1"
                     /locus_tag="GNZ18_RS21975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_21980"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_156218389.1"
                     /transl_table=11
                     /translation="MEYEVRLARPADLAVLPAIENSADPLFAPLGIVFPPGPTVIEQMD
                     GADVEILVAGDPPVAFAAVEEVDGATHLEQISVRGDLVGRGIGTRLLATVRERAAAAGS
                     PGVSLLTFRDVPWNGPWYAAHGFAELPEERWGPGLRAYWKAEIEAGLHDLGPRTVMWAP
                     SR"
     misc_feature    complement(4292..4301)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(4355..4996)
                     /locus_tag="GNZ18_RS21980"
                     /old_locus_tag="GNZ18_21985"
     CDS             complement(4355..4996)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544254.1"
                     /locus_tag="GNZ18_RS21980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_21985"
                     /product="response regulator transcription factor"
                     /protein_id="WP_156218390.1"
                     /transl_table=11
                     /translation="MTDRTLRVIVVDDHTVMRAGVVALLATEPGIEIVGEAGDGRAAVD
                     LAAGLRPDVALVDLRMPVLDGASATAEIVAGASGTRVLILTTYDTDAEIERAIEAGAVG
                     YLLKDTTRERLADAIRSAARGETVLAPRVAERLVARMRRPAQVPLTAREVDVLNGVADG
                     LSNADIGRRLVIAEATVKTHLLRVFAKLDVSDRTHAVVVAMERGLLPRPH"
     misc_feature    4947..4962
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.25"
                     /tool="antismash"
     gene            complement(4998..6206)
                     /locus_tag="GNZ18_RS21985"
                     /old_locus_tag="GNZ18_21990"
     CDS             complement(4998..6206)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="GNZ18_RS21985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_21990"
                     /product="sensor histidine kinase"
                     /protein_id="WP_156218391.1"
                     /transl_table=11
                     /translation="MDARPQLDDRFQVRALVRWYAALWLVLGLIPQVLAAADDPGAARV
                     SGIVLPVVLGACYAVTELYPRVLPPMAYLCVLAAGVGALSYVRGGGASLYIASLPQFWI
                     LTRSQRYAVALSGAAGLATLAGEVAAGAAHLPTGNMLFTVGGFLAGLLLGLAAHRYVRQ
                     TEERARRLSAELAVAQRELAEANRRQGAAEERERLAREIHDTLAQGFASIIVLAEAARA
                     GLGAEPGRSEQQLRSIERTARDNFAEARALVDSARRDGPAQGPVAATLRRVLDRFTEDT
                     GIPVGAELPDVECDQPARIALLRCTQESLANIRKHAGASSVGVVLERHPHGVELEITDD
                     GRGFVVGAAAGFGLEGMRRRLAELGGGLTVTSSVGDGTRIHVMIPLSPQDPPTPLISTS
                     PQE"
     misc_feature    complement(6172..6186)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.1"
                     /tool="antismash"
     gene            complement(6212..8374)
                     /locus_tag="GNZ18_RS21990"
                     /old_locus_tag="GNZ18_21995"
     CDS             complement(6212..8374)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.5"
                     /locus_tag="GNZ18_RS21990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_21995"
                     /product="MMPL family transporter"
                     /protein_id="WP_156218392.1"
                     /transl_table=11
                     /translation="MMNLPVRAARWSAGHPWRAIAGWFLFVALCLGVGISVGGHAATSA
                     DFRVGEAGRAEAMAAEGGLQNKPVERVMISGEGARDAAARDIAGRMKGLPEVESVAAPV
                     RAPGGDVVRVDVTLKGAELDGRKHVEPLREQTDAVRAAYPGLRVEETGGPSVSKGVEEL
                     RGKDLSRTEVIALPVTLITLLLVFGSVALAVVPLLLALSSIVAAVGLSMLASHVFPDAG
                     VGTNVILLIGLAVGVDYTLFYLKREREERARAGGRLSPRAVVELAAATSGHAVVVSGLA
                     VAVSSATLFLADDVIFSSLATGAIVVTLVAVASSMTVLPALLAKLGARAERRRERRARR
                     GKAVRAHREDGAGRITTALLRPTEKRPAVTLAVAVLAMLALASPLLGLKLTDMGRETHP
                     RSIPAVQSYHRMNAVFPELKSTHQVVVRADAGRSDEVRAALGDLAGRTRGDRRFAGAPS
                     LRTSADGRVSLLELPVPHYGSEDAARASLRDLRKRYIPASLGKLDADVAVSGDVARYTD
                     YPEHQKDKLPMIIGALLLVTFAMTAWAFRSVVLGLVGVVLNLLSAAASLGVLVAVFQYT
                     WAEGLLGFTSTGSIGSRVPLLLFVILFGLSMDYQVFVISRIREAALAGVPTRQAVLEGV
                     GGSARVVTSAAFVMVTVFASFVPLHIIEMKQMGFSLAVAVLLDAAIIRIMILPAAMLLL
                     GERSWWPSRGMRRVRAAAERPAEKVG"
     gene            8470..9369
                     /locus_tag="GNZ18_RS21995"
                     /old_locus_tag="GNZ18_22000"
     CDS             8470..9369
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891210.1"
                     /locus_tag="GNZ18_RS21995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22000"
                     /product="phosphotransferase"
                     /protein_id="WP_156218393.1"
                     /sec_met_domain="APH (E-value: 1.3e-23, bitscore: 78.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIYAETPLTGAMRKAVQDAWNVPADGPAERLFGGEESAAYRIGDL
                     VVRVGPAWRSDAETEWCHAVAAHAASRMPEAVAPLRARDGATVVRGDGRPLSLWRHVEG
                     EWPDTEEPTTRTQAAALLARLHRALADHAPPPRPTRSFAEIGLDGAFPEDVPELADPDL
                     DRWLAAFHARTPARQVVHGDYYEGNTLARGGRLVALLDWDEAFVAAPEFEVASAALEWT
                     DEHARAPELRRRFVADYHAAGGTAGPMDEETVAQLIRHRLRRETAYFNLARARGVEHDE
                     DDLDYHRRRVREFFALKP"
     misc_feature    9581..9598
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.69"
                     /tool="antismash"
     gene            9875..9982
                     /locus_tag="GNZ18_RS22000"
                     /old_locus_tag="GNZ18_22005"
     CDS             9875..9982
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039305.4"
                     /locus_tag="GNZ18_RS22000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22005"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_156218394.1"
                     /transl_table=11
                     /translation="MQKYETPALVAAGSFRKVTGLLGFHGNDRVILSKN"
     gene            10001..11833
                     /locus_tag="GNZ18_RS22005"
                     /old_locus_tag="GNZ18_22010"
     CDS             10001..11833
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="GNZ18_RS22005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22010"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_156218395.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.1e-45, bitscore:
                     151.4, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDHDGMPGHGEASFVVLPDHEAALAVAAGLPTPPERILRHRSGR
                     PWLAGRWSDAEMTEAAAGDARIAIIGTCPIGPERLAREAGRLRDLASLDRLVRSLPGSF
                     HLVAALDGRTRVQGDAAGLRLVFHTRAGGVTVAADRADTLAALTGAALDERQIAARLLW
                     PLPHPLLHTPLWRGVEGVEPGAHLLLEPDGRARTRRWWAAPEAVRPLATAADEVAAALT
                     AAVDARTAGGGVVSCDLSGGLDSTSICFLAARGEAEVVAATWPGRDPADEDLAWARRAA
                     AHLPGVEHTVWPAEDASLVYAGLLEIDDPLDEPSIGVMDRARMLDHVPRLAARGSRLHL
                     TGIGGDHVAWCSEAHYHGLLRRRPLLALRRLRGFRALFDWPLAPAARALADGRPYRRWL
                     LDAAGDLRAPARPAVAGALGWDTAPRLFDWVTPEAAEAAAQVLREAARTAEPLAPDRGQ
                     HLDLHSIRACTRIIRQWERMSARAGLPMASPFLDDRVIEACLAVRAEDRVTPWRYKPLL
                     VAAMRGVVPAECLARANKAEASMDAADGLRAHSRDLMELCEDSRLARLGLVDGERLKAL
                     LARPDTPALRGAILYSTLGCEVWLRTLDRRRARR"
     misc_feature    complement(11868..11881)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.43"
                     /tool="antismash"
     aSDomain        11871..12023
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GNZ18_RS22010_Lasso_Fused_RRE.1"
                     /evalue="7.60E-09"
                     /identifier="RREFam003.1"
                     /label="GNZ18_RS22010"
                     /locus_tag="GNZ18_RS22010"
                     /protein_end="51"
                     /protein_start="0"
                     /score="26.5"
                     /tool="antismash"
                     /translation="MGLRLRPGVSTTDTAYGTVLLDERSGDYWQLNPTAALALRLLADG
                     RTAEQA"
     gene            11871..12128
                     /locus_tag="GNZ18_RS22010"
                     /old_locus_tag="GNZ18_22015"
     CDS             11871..12128
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="GNZ18_RS22010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22015"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_156218396.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1e-07, bitscore:
                     26.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 7.5e-27,
                     bitscore: 87.8, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.7e-19, bitscore: 64.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLRLRPGVSTTDTAYGTVLLDERSGDYWQLNPTAALALRLLADG
                     RTAEQAAAAMAEEFDVDEPRALRDVTALVGQLRAAGLVRP"
     aSDomain        11877..12122
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GNZ18_RS22010_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.40E-28"
                     /identifier="RREFam002.1"
                     /label="GNZ18_RS22010"
                     /locus_tag="GNZ18_RS22010"
                     /protein_end="84"
                     /protein_start="2"
                     /score="87.8"
                     /tool="antismash"
                     /translation="LRLRPGVSTTDTAYGTVLLDERSGDYWQLNPTAALALRLLADGRT
                     AEQAAAAMAEEFDVDEPRALRDVTALVGQLRAAGLVR"
     gene            12125..12565
                     /locus_tag="GNZ18_RS22015"
                     /old_locus_tag="GNZ18_22020"
     CDS             12125..12565
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017559151.1"
                     /locus_tag="GNZ18_RS22015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22020"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_242887280.1"
                     /sec_met_domain="PF13471 (E-value: 2.6e-24, bitscore: 80.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPSALERPPKGPLRRRAAARLAVLLARLVALLPPARIRTLLTL
                     LSRGASPATYDQAKRARDAVLAGSLACLGPRGCLPRSLATVLLCRMWGVWPSWCVGARV
                     RPPFGAHAWVEAEGRLVEENVPDGYLAALITVPPRRDGARGR"
     gene            12555..14465
                     /locus_tag="GNZ18_RS22020"
                     /old_locus_tag="GNZ18_22025"
     CDS             12555..14465
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="GNZ18_RS22020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22025"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_216651400.1"
                     /transl_table=11
                     /translation="MDAEAPAPGGRAGHRRSTAGPREVLRLAAGHRGAIAATVAATLLA
                     SALALAQPLVARDVIAAAASGRTPWAAVGALVALFAGQALVQALVRFQLARTGEGIVLG
                     VRLNLIDHLLRLRMPVYDRHRIGDLISRADADTLALRQIIAGGLTDAVTGAIGLAATVV
                     LMLWLDWALFACVAAVVAGAGTALALALRGMRAASLRGREAAGEMAAGLERALSAIRTV
                     KAGRAEPRESARIGGRAEAAYAANVRMAGFDALVSPATQLAVTGSFLVVLLVGGTRVAG
                     GTGSVADLVAFLLYMLYLTAPLGSIFEAFSAVQQGTGAVHRITEALALPRETDAAPGLP
                     ALPRPPGATSGLAGDEVSAGPCAQGGTVAEPGANGGRAAALEFREVWFGYRRGRPVLRG
                     VSFQVPAGGHVALIGRSGAGKSTVFALAERFYDPDRGEVLVEGVRADSLSRDGHRSRIG
                     LVEQDCPVLDGTLRDNLVYAVPEAGEEEIRRAVAMTNLDELVSRLPEGLDTRVGEHGRE
                     LSGGERQRLAIARALVARPRLLLLDEPTSHLDLESEVALHRAIEEAAGRCALLVIAHRF
                     TTVRAAAGVIVLDQGRIAASGTHEQLLETSAYYRDLASQWLARRGDRSATGSGCEHAGR
                     G"
     gene            complement(15048..17165)
                     /gene="uvrB"
                     /locus_tag="GNZ18_RS22025"
                     /old_locus_tag="GNZ18_22030"
     CDS             complement(15048..17165)
                     /EC_number="3.1.25.-"
                     /GO_component="GO:0009380 - excinuclease repair complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="uvrB"
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657177.1"
                     /locus_tag="GNZ18_RS22025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22030"
                     /product="excinuclease ABC subunit UvrB"
                     /protein_id="WP_156218397.1"
                     /transl_table=11
                     /translation="MRPVTDLRRRVAPFEVVTEMTPSGDQPQAISELAERIGRGDKDAV
                     LLGATGTGKTATIAWLVEKLQRPVLVMQPNKTLAAQFANELREMMPGNAVEYFVSYYDY
                     YQPEAYIPQTDTYIEKDSSINDEVDRLRHSATNSLLTRRDTVVVASVSCIYGLGTPQEY
                     VDRMVRLQTGQRIERDDLLRQLVGMQYTRNDLAFTRGTFRVRGDTVEIIPQYEELAVRI
                     EMFGDEIEKLATLHPLTGEVITEDDELYVFPASHYVAGPERMERAIAGIEAELEETLAV
                     MERQGKLLEAQRLRMRTTYDVEMMRQVGTCSGIENYSRHIDGRGAGTAPNTLLDYFPED
                     FLLVIDESHQTVPQIGAMYEGDASRKRMLVEHGFRLPSAIDNRPLKWEEFLERIGQTVY
                     LSATPGNYEMTRVGGDVVEQVIRPTGLIDPEIVVKPTKGQIDDLIHEIRLRTDKDERVL
                     VTTLTKKMSEDLTDYLLELGIQVRYLHSEVDTLRRIELLRELRAGEFDVLVGINLLREG
                     LDLPEVSLVAILDADKEGFLRSETSLIQTIGRAARNVSGQVHMYADTVTPSMERAIDET
                     NRRRAKQQAYNTEHGIEPQALRKRIADILDSLAREDADTETLIGGAGRQQSRGKAPVPG
                     LASRTREVGRHAADLVGERPREELEGLIEQMTAQMHQAATDLQFELAARLRDEIKELKR
                     ELREMKEAGVS"
     misc_feature    complement(17213..17228)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            complement(17254..18408)
                     /locus_tag="GNZ18_RS22030"
                     /old_locus_tag="GNZ18_22035"
     CDS             complement(17254..18408)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657178.1"
                     /locus_tag="GNZ18_RS22030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22035"
                     /product="sensor histidine kinase"
                     /protein_id="WP_156218398.1"
                     /transl_table=11
                     /translation="MQLRGWWSAAWPTPRSRALDLTLAVSLAVVDGVFLWFAPQDFWLP
                     PAVTSVGSFLLGLGLVFRRRHPVRLALVAVALGTVAGAGVFALVVILYSLAAYTPNRRT
                     VWTIAAFGYVSGIAFPGPTESDDPFLAQAIFGVAFTAVPILLGLYMGARKQLLASLQER
                     ASRLEREQHLLAERARGEERTRIAREMHDVVANRISVMVVHAGALKAIAVRDPGRAAET
                     ATVIGDMGRQALEELRHVIGVLRQGEEALPQEAVTLAHVRELVDQSGAAGLVVDLAVRG
                     EERPMPPAVGRTVYRLVQEALTNVHKHAGAADTRVGLGLLPEAVEVEIANDAPTAPPDH
                     GLPSGGHGLVGLRERVTALGGSFEAGPSADGGYAVRARLPLPAS"
     misc_feature    18583..18594
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.15"
                     /tool="antismash"
     gene            18596..19609
                     /locus_tag="GNZ18_RS22035"
                     /old_locus_tag="GNZ18_22040"
     CDS             18596..19609
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543765.1"
                     /locus_tag="GNZ18_RS22035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22040"
                     /product="hypothetical protein"
                     /protein_id="WP_156218399.1"
                     /transl_table=11
                     /translation="MTRFATWLGKNADAFIALILAITVAVLGVGVDLPHEDEVTNSAIL
                     AVVGLLATSVLRDRGRRVPVEAEVRDTLRASSATLDELSGKLTHIETFEGVLADTKRAL
                     DETTIVRVISGAQVAQVLEEARRDTDRWIFKGGTGTYIRAKTLPETVAAARRDGRTLLF
                     RLEIIDPTDVEVCEAYARHRRSSADGPDGTGEPWTLERTRKEAYATILAACWHKQRFGM
                     LDIDIGLARTMTTLRYDLSSSLIVVTRDNPRGQALVVDSTKFYYSWLSAELLTSLDQAR
                     RVPVEQARLAPLDDEPTVEEVRRLFEVIGIDMAQGYTDRDVIEIIRKALRPKDPYE"
     gene            19674..20390
                     /locus_tag="GNZ18_RS22040"
                     /old_locus_tag="GNZ18_22045"
     CDS             19674..20390
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889677.1"
                     /locus_tag="GNZ18_RS22040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22045"
                     /product="hypothetical protein"
                     /protein_id="WP_214617874.1"
                     /transl_table=11
                     /translation="MRYEEIRREIEAGTAARTLPAWAGRVLADVAEGRSRVPAVRHPLG
                     FLCLPVERAGDFGVCLHIWTSEVDPAPSTTSPVHCHSWDLLSFVLYGTVRNVRMDVGEG
                     PGGAAAQVFEVVSRGEVDELRATGRTVRYSPGRSTAHGTGESYTLPAGVFHSTLIEDGR
                     DAATVALGRQTPGGGDLSLGPPDVATHRVRRARSDPGEAARALHRSAREVANAYAARPA
                     PPGPGRPRDDLSPTRR"
     gene            20438..21331
                     /locus_tag="GNZ18_RS22045"
                     /old_locus_tag="GNZ18_22050"
     CDS             20438..21331
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889676.1"
                     /locus_tag="GNZ18_RS22045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22050"
                     /product="inositol monophosphatase"
                     /protein_id="WP_156218400.1"
                     /transl_table=11
                     /translation="MRSTTASPALPVDLGEARRVAVDAAEAAGALLRAGTGGPLVARPK
                     GGNGDVVTELDTAAEELILGRLRAAYPGHRIIAEESGVLDGADGSHLVWLVDPLDGTNN
                     VAIGMPVYAVGLALCAGSVPVLGVVHDPVSGRTWTAVRGEGALDPDGAPLTLAPRPRPG
                     RERNPVLGWTQGHAVKAGDPSALALRTALELRCSRLLQLWAPLVAWAMLARGDIDGIVG
                     YRPELVDLPPGALLAAEAGAELRRLDGGPYELSIDRTPSELGFVAARPELLARLVETAN
                     RALDTAGPDGQIPLVR"
     gene            complement(21332..22555)
                     /locus_tag="GNZ18_RS22050"
                     /old_locus_tag="GNZ18_22055"
     CDS             complement(21332..22555)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630649.1"
                     /locus_tag="GNZ18_RS22050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_22055"
                     /product="SLC13 family permease"
                     /protein_id="WP_312874664.1"
                     /transl_table=11
                     /translation="MPSPPATLRRAVRSMGLLDRVRVGLLALGLVFVATGLLPPATARD
                     SVERIAPLLLFLLSVIVLAELTKEAGVFDAIAQRMASAGRGNYAALFLLCVGFAAATTV
                     FLNLDTTAVLLTPVMLALAARARIAALPLAMTTVWLANTASLLLPVSNLTNLLAADRVA
                     LETPAFAARMWLPQVAVLAVTMLLLWAFFWRRGMRGADTYDPPDVAPVRDRVLFSATGA
                     ACLLFIGAILAGVHTGLQLGLAATAAAVVAVAAFAVRDRSALRGELVPWRLMVFVTGLF
                     LVVPTLERYGLDEVMRSLVGGDDGAAGAVRAGFAGAGLSNVLNNLPAYVAGESAVPEAN
                     RDQLLSLLIGTNVGPVITPWGSLATLLWFEWCRRWDVRVPMRKFVLTGTVLAVLGCAAA
                     IAALPATR"
ORIGIN
        1 acgtcgtgag cgtgctgcgg ccgcgcgccc cccacaccgt cggctaccgc ggccccggcg
       61 acatctccag caaggtcaag gccgcctgcg acaacggccg gcccccctac accctcgtgt
      121 acttcgccgg gcgtgccgag gacctgcccg gcctgatgaa cggcctcgtc cagggcggct
      181 gcacccggca ccgcctgctc ctgatcgcgg gcgacgacgt cagcaagtcc cgcttcggca
      241 ccggtccgca cgaggtgccg ctcccccaga acaccaccct gtaccacacc gtgttcgcct
      301 acctgcccca cctgatcgcc aaggacgccg acgtgaccgg cgacttcttc ctcatggccc
      361 gcaaccgctt cggcatcggc gccccccgcg tccggcccga cgagccgctg ctggtggacg
      421 gccagatggc catcaccttc gacgccacgt tcgcgctgag ccaggccgcg cagaacgcct
      481 acgacctgct cggcccccgg ctggtgacgg gcgagcggtc cgtcacgtcc gggacggtgc
      541 tggaggagct gcggcacctg cggatcacgc ggggcggctc ggcgaccggc gacatcgact
      601 tcaccaacga ccacggggac ccgccgcggc cccgcaaccg gggcctcacg ctcgtcaagg
      661 tcaccctgaa ggacggccgg ccgcagccca ccgcgatctg cggccgcctc ggcggcggcg
      721 tgccggtcga gggcctgcgg ccgtgctgac gcctcacccc ggccgcagga ccgtgctgcg
      781 gcccccgcag gcgtcgcggc ggcggccgca cacctggagg tggacggccg aggacgcgcc
      841 cgtccaggcg taggcgaagg cgacctcgcg ggtctgcccg caggcgaggc ccgccgcgtg
      901 ctcggcgtcg ggcagcccgg ccagcaccac ggtgatcttc aggtaggacg ggccgtcctc
      961 gcagcgcagg tcccggtgcg tgccccgcac caccacccct cgcgcgccga ccgtgaccgt
     1021 gccgtggctg acgccctgcc cgcgcaacgt cttcgcgtag cgcaggccgc ggttccccct
     1081 ggccgcgccc cgcccgttcc gctgcgccga cgtcgccgag accgtggaca tcgtcagcgg
     1141 gacggacacc ccctccaccg cgccgtaccc cacgatcgcg acggccggca cgagcacggc
     1201 cgccgacagc aggccgagcg ccggcctcac ccagatcatc tgccccctcg acacctcgcg
     1261 atccgccggt gccgacgagg ctaagggctc gtgatcaccc gccctagggc cctagggccc
     1321 tatgcgcgag cggccgggac cccaatgcgg gctagggcgt gcgggtgagc caggtgacct
     1381 gggtgccgtt gtcgaactcc tcgcgcgccg tcggcgtgaa ccgggtcggc cggaacccgc
     1441 ccgcgaaggc ggggacgccc gcccccgcca ccaccgggta gctcttgacg atcatctcgt
     1501 cgatctccgg cagcagcgcg gcggcgagcc tgccgccgcc cgcgagccag acgtccatgc
     1561 cgccgtcctc ggccttgagc gagcgggcga gctccagcgg gtcgcggacg agcgtcacgg
     1621 cggggtcggc gatctcgggc agcgtggtgg aggcgacgta ctgccggacg tgcgcgtagg
     1681 ggctggtcac gccgatgtcg agggccggcc ggtaggtccc gaggcccatc acgagcgtgt
     1741 cgaagcgctg gttcggcgcg tcctggatgc cgaggtgcgg gcggacgtgc gtcgggagcg
     1801 tctcgggata gtgctcgccg atccaggcca tcacctggtc gctgaccggc aggaagtcga
     1861 tctcaccgcc ggggcccgcg atgaagccgt cgaggctcgt tccgacgtag tagacgagct
     1921 tgcgcatagg ggattccgtt cgtagtactc tacttgaagt ggttggaacg tagtactacg
     1981 tctggagtgg tgtcaagtga ggaagaacgt cgagcggcgc gccgccctgg tcgacgcggc
     2041 gatcgaggtg ctggccaggg acggcgcgcg cggcctgacg ttccgcgcgg tggacgccga
     2101 ggccggcgtg cccgtcggca ccgcgtccaa ctacttcgcc aagcgcgacg acctgttcac
     2161 gcaggcgggc gggcggatct acgagcggct ccagccggac gcggccacgc tcggcggcat
     2221 gctggagggc ccccgcgacc tggcccgggt caccgcgctg ctgaccgaga ccgtcggccg
     2281 gatctcggcg ttccggaccg gctacctcgc cctgctggag ctgcggctgg aggccacccg
     2341 gcggcccggg ctgcgcgccg tcctgaccga gcgggtgcgc gaggacgtcg aggcgaacgt
     2401 ggcgcggcac ctggagtcgg gcatgccggg cgacgccacc accgtccggc tgctgtacct
     2461 gacgctgaac tggctgatcg tcgagaacct gaccctgccg gaggtgttca ccgaggagga
     2521 cgtgcggcgc ctcgtcgccg acgccgtcga acgctccctc ccccggcagg acccccgcta
     2581 ggagacgggg cggcccggcc ccttcttgac ctgctcgatg aacagcccgg cgagggcgtg
     2641 ctggccgctc accgtggggt ggtagctgcg cggctcggcc tccagggccg acaggttcac
     2701 cgtgaggccg ttcatgtacg gctggccgct gccgacctcg tggcccgcga acgcgctgta
     2761 ggagtcgacg aactcgacgc tgccctgctg gtgccgggcg gcgatgcggc ggtcggcctc
     2821 ggcggcggtc tcccggatga gccgcccgag gtcgtaggcg cgcgcgttga gccactgctg
     2881 ctccgacacc ctgaggttgt cgccgccggt gccctccacc tcggagaacg ccttcgggta
     2941 gcccatcagg atgatgcggg cgtggggtgc gcgcgcgtgg atctggccga tcagctcggg
     3001 caggttgcgg cgcaggtcgg acatcttcct ggcgatgtcg tcgccctgcc tgaagcagct
     3061 cctgctccac ggcagcttca ccacgcagcc cgcgacgacc ttggagaacc cgatgtcgtt
     3121 gccgccgacg ctcagcgtga cgaggctcgt gtcggcgttg agccggccga gctgcgaggg
     3181 ctcaccgtgc ctgccgtcgc ggatgtccgc cgtggtggcg cccgagcacg cccagaacga
     3241 ggtgcccttg gcgaacggga acgccttgga gacctcgttg tagtacgcct tggacgtccg
     3301 gtggcagcgc tccagcgggt tgttgtcgcc gacggtcgcc tcggcgccga caccggagga
     3361 gtaggagtcg ccgagcgcga cgtagccgcc ccgcgtcgcc gcctccaccg gggtgaactg
     3421 gcggcccggc gccgacaccg ggtcggcgcg gacctcgggc ggcggcgtgc ggcacccgct
     3481 cccgaacacc tcgcagcgga cggccggcag cgccaccagc gggacgaccg ccagcgccag
     3541 caacgccacc agcgcggtca gcgcgagccc ccgctcgccg aaacgcccgc gcgcccaccg
     3601 tgcccatgac cccggacccg tcatcgtcct cctccggctc cctcaggctg acgctcgcgc
     3661 gacgtcaccg gttcccacct ttacattgta gatttttagt ggcgcaccgc cgtccccggc
     3721 gggtctccgg gagaccacat tacgtgccgg ggcggtgccg gggcggcgct cagcgggacg
     3781 gcgcccacat gaccgtccgg gggcccaggt cgtgcaggcc cgcctcgatc tcggccttcc
     3841 agtaggcgcg caggccgggc ccccagcgct cctcgggcag ctcggcgaac ccgtgcgcgg
     3901 cataccatgg cccgttccac gggacgtcgc ggaacgtcag caggctgacg cccggcgagc
     3961 cggcggcggc cgcgcgctcg cgcaccgtcg ccagcagccg ggtgccgatc ccccggccca
     4021 ccaggtcgcc ccgtacggag atctgctcca ggtgggtcgc accgtccacc tcctcgacgg
     4081 cggcgaacgc caccggcggg tcgcccgcca cgaggatctc cacgtccgcg ccgtccatct
     4141 gctcgatcac cgtcgggccc ggcgggaaca cgatcccgag cggggcgaac agcgggtcgg
     4201 ccgagttctc gatcgccggc agcaccgcca gatcggcggg tcgcgccagg cgcacctcgt
     4261 actccatacg gcgatggtag gtccccgccg gggccgcctt cccggactcc cgcgcgacac
     4321 ttccgggacg ttcgcgcggg cggccccggg agggtcagtg cggccggggc agcagcccgc
     4381 gctccatcgc cacgacgacc gcgtgcgtgc ggtcgctgac gtcgagcttc gcgaacaccc
     4441 gcagcaggtg cgtcttcacc gtcgcctccg cgatcacgag ccgccggccg atgtcggcgt
     4501 tggacaggcc gtcggcgacg ccgttcagca cgtccacctc gcgcgcggtc agcggcacct
     4561 gcgcgggccg ccgcatccgc gccaccaggc gctcggcgac ccgcggcgcg agcacggtct
     4621 cgccgcgcgc cgccgacctg atcgcgtcgg cgagccgctc gcgggtggtg tccttgagca
     4681 ggtagccgac cgcgcccgcc tcgatcgccc gctcgatctc ggcgtcggtg tcgtaggtgg
     4741 tgaggatcag cacccgcgtc cccgacgcgc ccgcgacgat ctcggcggtg gcgctcgccc
     4801 cgtccaggac gggcatccgc aggtcgacca gcgccacgtc gggccggagc ccggcggcga
     4861 ggtcgacggc cgcgcggccg tcgcccgcct cgccgacgat ctcgatgccg ggctcggtgg
     4921 ccagcagcgc caccaccccg gcgcgcatca ccgtgtggtc gtccaccacg atgacgcgga
     4981 gcgtgcggtc ggtcatgtca ctcctgcggg ctcgtcgaga tcaggggggt cggcgggtcc
     5041 tgcgggctca gcgggatcat cacgtggatc cgggtgccgt cgccgaccga gctggtgacg
     5101 gtcagcccac cgccgagctc ggccagccgg cggcgcatgc cctccaggcc gaagccggcg
     5161 gcggcgccga ccacgaagcc gcggccgtcg tcggtgatct ccagctcgac gccgtgcggg
     5221 tggcgctcca gcacgacgcc gaccgacgag gcgcccgcgt gcttgcggat gttcgcgagc
     5281 gactcctgcg tgcagcgcag cagcgcgatc cgggccggct ggtcgcactc gacgtcgggc
     5341 agctccgcgc cgacggggat gccggtgtcc tcggtgaagc ggtccaggac gcggcggagc
     5401 gtcgccgcga ccgggccctg cgcggggccg tcgcgccgcg cggagtcgac cagggcgcgc
     5461 gcctccgcga agttgtcgcg cgccgtccgc tcgatcgagc ggagctgctg ctcgctgcgg
     5521 cccggctcgg cgccgagccc cgcgcgggcc gcctccgcca gcacgatgat cgaggcgaag
     5581 ccctgcgcga gcgtgtcgtg gatctcccgg gcgaggcgct cgcgctcctc cgccgcgccc
     5641 tgccgccggt tcgcctcggc cagctcccgc tgcgccaccg ccagctccgc cgacagccgc
     5701 cgcgcccgct cctcggtctg ccgcacgtac cggtgcgccg ccaggccgag cagcagcccg
     5761 gccaggaagc cgccgacggt gaagagcatg ttgccggtcg ggaggtgcgc ggcgcccgcc
     5821 gcgacctccc cggccagcgt cgccagcccg gcggcgccgc tcagcgcgac cgcgtaccgc
     5881 tggctcctgg tgaggatcca gaactgcggg agggaggcga tgtagagcga ggcaccgcct
     5941 ccccgcacgt acgacagggc gcccacaccg gcggcgagca cgcagaggta cgccatcggc
     6001 ggcagcacgc gcgggtacag ctccgtcacc gcgtagcagg cgccgagcac gaccggcagc
     6061 acgatccccg agacccgcgc cgcgccgggg tcgtcggccg cggcgaggac ctgcgggatc
     6121 aaccccagca cgagccacag cgcggcgtac caccggacga gggcgcggac ctggaaccga
     6181 tcgtcgagct gcggccgggc gtccatgccg gtcagcctac tttttcggcg ggacgctccg
     6241 ccgcggcccg cacccggcgc atcccccgcg agggccacca gctccgctcc ccgagcagca
     6301 gcatcgccgc cggcaggatc atgatccgga tgatcgccgc gtccagcagc accgcgaccg
     6361 cgaggctgaa ccccatctgc ttcatctcga tgatgtgcag cggcacgaag ctcgcgaaca
     6421 ccgtcaccat cacgaacgcc gcgctcgtca cgacccgcgc ggacccgccg acgccctcca
     6481 ggacggcctg ccgggtcggc accccggcca gggccgcctc ccggatgcgg ctgatcacga
     6541 acacctggta gtccatcgac aggccgaaca ggatcacgaa cagcagcagc gggacgcgcg
     6601 agccgatcga ccccgtcgag gtgaagccga gcaggccctc cgcccaggtg tactggaaca
     6661 ccgccaccag cacgccgagc gacgcggcgg ccgacagcag gttcagcacg acgccgacca
     6721 ggccgagcac caccgaccgg aacgcccacg cggtcatcgc gaacgtcacc agcagcagcg
     6781 ccccgatgat catcggcagc ttgtccttct ggtgctcggg gtagtcggtg tagcgggcga
     6841 cgtccccgga caccgcgacg tccgcgtcca gctttccgag cgaggccggg atgtaccgct
     6901 tcctgaggtc gcgcagggaa gcacgcgccg cgtcctcgct gccgtagtgc gggacgggca
     6961 gctccaggag gctgacccgg ccgtccgccg aggtgcgcag gctcggggcg cccgcgaagc
     7021 gccggtcgcc gcgcgtgcgc ccggcgaggt cgccgagggc ggcgcgcacc tcgtccgacc
     7081 gtccggcgtc ggcgcggacg acgacctggt gcgtggactt cagctccggg aacaccgcgt
     7141 tcatgcggtg gtaggactgg acggcgggga tgctgcgggg atgcgtctcc cggcccatgt
     7201 ccgtgagctt gaggccgagc agcggggagg cgagcgccag catcgccagc acggcgacgg
     7261 ccagggtgac cgcggggcgc ttctcggtgg ggcgcagcag cgccgtggtg atccgcccgg
     7321 cgccgtcctc gcggtgcgcc cggacggcct tgccgcgccg cgccctgcgc tcccggcgcc
     7381 gctcggcccg cgcgccgagc ttcgcgagca gcgcgggcag gacggtcatc gagctggcca
     7441 ccgcgaccag cgtcaccacg atcgcgccgg tggcgagcga ggagaagatc acgtcgtcgg
     7501 ccaggaacag cgtcgcgctc gacaccgcga ccgcgaggcc ggacaccacc acggcgtgcc
     7561 ccgaggtcgc cgcggccagc tccaccaccg cccgcgggct gagccgtccg cccgcgcggg
     7621 cccgctcctc ccgctcccgc ttgaggtaga agagggtgta gtcgacgccg acggccagcc
     7681 cgatcagcag gatgacgttc gtgccgaccc ccgcgtccgg gaacacgtgc gaggcgagca
     7741 tcgacaggcc caccgccgcg acgatcgacg acagcgccag cagcagcggc accaccgcga
     7801 gcgccaccga cccgaagacc agcagcagcg tgatcagcgt caccgggagc gcgatcacct
     7861 cggtgcgcga gaggtccttc ccgcgcagct cctcgacgcc cttgctgacc gacggcccgc
     7921 cggtctcctc cacccgcagc cccgggtagg cggcccgcac cgcgtcggtc tgctcccgga
     7981 gcggctcgac gtgcttgcgc ccgtccagct cggcgccctt gagggtcacg tcgacgcgga
     8041 cgacgtcccc gccgggggcc cgcaccggcg cggcgaccga ctcgacctcc ggcagcccct
     8101 tcatccgtcc cgcgatgtcg cgcgcggcgg cgtccctggc cccctcgccc gagatcatca
     8161 cccgctcgac gggcttgttc tggagcccgc cctcggccgc catcgcctcc gcccggccgg
     8221 cctcgccgac ccggaagtcc gcggacgtgg cggcgtggcc gcccaccgag atgcccacgc
     8281 cgaggcacag cgcgacgaac aggaaccatc cggcgatcgc ccgccagggg tgcccggcgc
     8341 tccaccgggc cgcgcgtact ggaagattca tcatgtgctc gatgctgctg gccgggcccc
     8401 cttccccggc agcggcgaac ggctgaacct gccgtccacc gatcggtgga ccccccggaa
     8461 ggagacagga tgatctacgc cgagacgccg ctcacgggcg ccatgcggaa ggcggtccag
     8521 gatgcttgga acgttcccgc cgacggcccc gccgagcggc tgttcggcgg cgaggagtcg
     8581 gccgcgtacc ggatcggcga tctcgtggtg cgcgtcggcc ccgcctggcg gagcgacgcc
     8641 gagaccgagt ggtgccacgc ggtggcggcg cacgccgcgt cccgcatgcc cgaggcggtg
     8701 gcgccgctgc gcgcccgcga cggcgccacg gtcgtccggg gcgacggccg cccgctgtcg
     8761 ctgtggcgcc acgtggaggg cgagtggccc gacaccgagg agcccacgac gcgcacgcag
     8821 gccgccgcgc tcctcgcccg gctgcaccgg gcgctggccg accacgcccc gccgccgcgt
     8881 ccgacccgct ccttcgccga gatcgggttg gacggcgcct tccccgagga cgtccccgaa
     8941 ctcgccgacc ccgacctcga ccggtggctc gcggccttcc acgcccgcac cccggcgcgc
     9001 caggtcgtcc acggcgacta ctacgagggc aacaccctgg cgcgcggcgg ccgcctggtc
     9061 gccctcctgg actgggacga ggcgttcgtc gccgcccccg agttcgaggt ggcctccgcc
     9121 gccctcgaat ggacggacga gcacgcgcgg gcccccgagc tgcggcgccg cttcgtcgcc
     9181 gactaccacg cggcgggcgg caccgccggg cccatggacg aggagaccgt cgcccagctc
     9241 atccgccacc gcctccggcg cgagaccgcc tacttcaacc tggcacgcgc gcgaggcgtc
     9301 gagcacgacg aggacgatct cgactaccac cggcgccgcg tgcgggagtt cttcgccctg
     9361 aagccgtagc cggccctcgg gctcccgcac ctaaaggacg ggtcaagggg aattcccaag
     9421 tacccgaaca aaggccggta caaagagcgg ggcgataggc ggggcgaagg ccggaccaaa
     9481 gggcgggcga cctcccgtac ccccgttcga cgcgaccgga tattggaccg cgcacacccg
     9541 tcctcatagg tcgcgtattt gcaccaagcg gcatcattct gggttacgga caggttaata
     9601 tgatccttcg cctgtggcac cgaacaatgt ccgcagggac aggtaatccg atttaccgga
     9661 agccccatac caccgggtat ggttgcctta tcccgttttc tcctcctcga agccgccatc
     9721 gatcgctccg gcgccatgaa gatcggatat cggcgggatg gtcaaccggc gcgcccggat
     9781 gtcatgcttc tcgcgtttcg cattccaccg agaagagcgg aaggcggaac acgggagatc
     9841 tcccctggga aacccacggc aagaggagga gaaaatgcag aagtacgaga cccccgccct
     9901 tgtggcggcc ggctccttcc gcaaggtcac cggactgctc ggcttccacg gcaacgaccg
     9961 tgtgatcctc agcaagaact gagccgggcg ttcacggccc atgcctgatc acgatggcat
    10021 gccgggccac ggcgaggcgt ccttcgtggt ccttccggac cacgaggcgg ccctcgccgt
    10081 ggccgcgggc ctgcccacac cccccgaacg catcctgcgg caccgctccg ggcggccctg
    10141 gctggcgggc cgctggagcg acgccgagat gaccgaggcc gcggcgggag acgcccggat
    10201 cgcgatcatc ggcacctgcc cgatcggtcc cgagcggctc gcccgggagg ccgggcggct
    10261 gcgcgacctc gcctccctcg accggctcgt ccgctccctg ccgggaagct tccacctggt
    10321 cgccgcgctg gacggccgga cgcgcgtcca gggcgacgcc gccgggctgc ggctggtctt
    10381 ccacacccgc gcgggcggcg tcacggtggc cgccgaccgc gccgacacgc tcgcggccct
    10441 gaccggggcc gcgctggacg agcgccagat cgccgcgcgc ctgctgtggc cgctcccgca
    10501 cccgctgctc cacacaccgc tgtggcgcgg ggtcgaaggc gtcgagccgg gtgcccacct
    10561 gctgctggag ccggacggcc gcgcgcggac gcgccgctgg tgggccgcgc cggaggcggt
    10621 gcgcccgctc gccaccgccg cggacgaggt cgcggcggcg ctcaccgcgg cggtcgacgc
    10681 gcgcaccgcg ggcggcggcg tcgtgagctg cgacctgtcc ggcggcctgg actcgacctc
    10741 gatctgcttc ctggcggccc ggggcgaggc cgaggtcgtc gccgccacct ggcccggccg
    10801 cgatccggcc gacgaggacc tggcctgggc gcggcgcgcc gccgcgcacc tgcccggtgt
    10861 cgagcacacg gtctggcccg ccgaggacgc gtcgctggtc tacgcggggc tcctggagat
    10921 cgacgacccg ctggacgagc cgagcatcgg cgtgatggac cgcgcccgca tgctcgacca
    10981 cgtcccccgg ctggcggcca ggggcagccg cctgcacctg accggcatcg gcggcgacca
    11041 cgtcgcctgg tgctccgagg cccactacca cgggctgctg cgcaggcggc cgctcctcgc
    11101 gctgcggcgg ctgcgggggt tccgggcgct gttcgactgg ccgctcgccc cggcggcgcg
    11161 cgccctggcc gacggccgcc cctaccgccg gtggctcctg gacgcggccg gtgacctccg
    11221 cgcccccgcc cgcccggccg tcgcgggcgc gctcggctgg gacacggctc cgcgcctgtt
    11281 cgactgggtc acccccgagg cggcggaggc ggcggcgcag gtgctgcgcg aggccgcccg
    11341 gacggccgag ccgctggccc ccgaccgggg gcagcacctc gacctgcact cgatccgggc
    11401 ctgtacccgc atcatccggc agtgggagcg gatgagcgcc cgcgccggcc tgccgatggc
    11461 ctcgcccttc ctggacgacc gggtcatcga ggcctgcctc gccgtgcgcg cggaggaccg
    11521 ggtcaccccg tggcggtaca agccgctcct cgtcgcggcc atgcgcggcg tcgtcccggc
    11581 cgaatgcctc gcacgcgcca acaaggcgga ggcgtccatg gacgccgccg acgggctgcg
    11641 cgcgcacagc cgcgacctga tggagctgtg cgaggactcc cggctggccc ggctcggcct
    11701 cgtcgacggc gagcggctga aggccctcct cgcccgtccc gacacgcccg cgctgcgcgg
    11761 ggcgatcctg tactccacgc tcggctgcga ggtctggctg cgcaccctgg accgccggcg
    11821 cgcgcggcga tgacccgtcc ggaagaccgg tactgaaagg aagaccccgc atgggtttgc
    11881 gactgcgccc cggcgtgtcc acgaccgaca ccgcctacgg cacggtgctc ctcgacgagc
    11941 gcagcggcga ctactggcag ctcaatccga ccgccgccct ggccctgcgg ctgctggcgg
    12001 acggccgcac cgccgagcag gccgccgcgg ccatggccga ggagttcgac gtcgacgagc
    12061 cgcgggcgct gcgggacgtc acggcgctgg tgggacagct gcgcgcggcg ggactggtgc
    12121 ggccgtgacc gtcccgagcg cgctggagcg ccccccgaag ggcccgctgc ggcgccgcgc
    12181 ggccgcgcgg ctggccgtcc tgctggcccg gctcgtcgcc cttctgccgc ccgcgcggat
    12241 ccgcacgctc ctcaccctgc tctccagggg cgcctccccc gccacctatg accaggcgaa
    12301 gcgggcgcgc gacgccgtcc tcgccggcag cctcgcctgc ctcgggccgc gggggtgcct
    12361 gccccggtcg ctggcgaccg tcctgctgtg ccggatgtgg ggcgtgtggc cgagctggtg
    12421 cgtcggcgcc cgggtgcggc cgccgttcgg ggcgcacgcg tgggtggagg ccgagggccg
    12481 cctcgtggag gagaacgtgc cggacggcta cctcgccgcg ctgatcaccg tgccaccgcg
    12541 ccgggacggg gcccgtggac gctgaggcgc ccgcgccggg cggccgggcc gggcaccgga
    12601 ggagcacggc gggaccgcgc gaggtgctgc ggctggccgc cgggcaccgc ggcgccatcg
    12661 ccgccaccgt cgcggcgacc ctgctggcgt cggcgctggc gctggcccag cccctggtcg
    12721 cgcgggacgt gatcgcggcc gccgcgtcgg gccggacgcc gtgggccgcc gtgggggcgc
    12781 tggtcgcgct gttcgccggc caggcgctgg tgcaggccct ggtccgcttc cagctcgcgc
    12841 ggaccggcga ggggatcgtc ctcggcgtcc ggctgaacct gatcgaccac ctgctgcggc
    12901 tccgcatgcc cgtctacgac cggcaccgga tcggcgacct gatctccagg gcggacgcgg
    12961 acaccctcgc gctgcggcag atcatcgcgg gcgggctcac cgacgccgtg accggcgcca
    13021 tcggcctggc cgcgacggtg gtgctgatgc tctggctgga ctgggcgctg ttcgcctgcg
    13081 tcgcggccgt cgtcgcgggc gcgggcacgg ccctcgccct cgcgctgcgg ggcatgcggg
    13141 ccgcgtcgct gcggggtcgg gaggcggccg gcgagatggc cgccggtctg gaacgcgcgc
    13201 tcagcgcgat ccgcaccgtg aaggccgggc gcgccgagcc ccgcgagagc gcccgcatcg
    13261 gcgggcgcgc cgaggccgcc tatgccgcga acgtccggat ggccggtttc gacgcgctgg
    13321 tctcccccgc cacccagctc gcggtgaccg gctccttcct cgtggtcctc ctggtgggcg
    13381 ggacgcgcgt cgcgggcggc acgggctccg tcgccgacct ggtcgcgttc ctgctctaca
    13441 tgctgtacct gacggcgccg ctgggctcga tcttcgaggc gttcagcgcc gtccagcagg
    13501 gcaccggggc cgtccaccgg atcaccgagg ccctggcact gccccgggag accgacgccg
    13561 ccccgggcct ccccgcgctg ccccgcccac ctggcgcgac cagcggactc gccggggacg
    13621 aggtctccgc cgggccctgc gctcagggcg gcaccgtagc ggagcccggt gcgaacggtg
    13681 gccgagcggc cgcactggag ttccgggagg tgtggttcgg gtaccggcgg gggcggccgg
    13741 tgctgcgggg ggtgtcgttc caggtgccgg cgggcgggca cgtggccctg atcgggcgct
    13801 ccggcgcggg caagtcgacg gtcttcgcgc tcgccgagcg gttctatgat cccgaccgcg
    13861 gcgaggtgct ggtcgagggc gtgcgggccg actcactgag ccgcgacggc caccggtcga
    13921 ggatcgggct ggtcgagcag gactgcccgg ttctggacgg gaccctgcgc gacaacctgg
    13981 tctacgcggt cccggaggcc ggggaggagg agatccgccg ggcggtcgcc atgaccaacc
    14041 tggacgagct ggtctcgcgg ctgcccgagg ggctggacac ccgcgtcggc gagcacggga
    14101 gggagctgtc gggcggggag cggcagcgcc tggcgatcgc ccgcgcgctc gtcgcgcggc
    14161 cccgtctcct gctgctggac gagccgacct cgcatctgga cctggagagc gaggtggcgc
    14221 tgcaccgcgc gatcgaggag gccgccgggc ggtgcgcgct gctcgtcatc gcgcaccgct
    14281 tcaccaccgt ccgcgcggcg gcgggcgtca tcgtcctcga ccagggcagg atcgccgcgt
    14341 ccggcaccca tgagcaactc ctggagacca gcgcctacta ccgcgacctc gcctcgcagt
    14401 ggctggcgcg ccggggagac cgctccgcca ccgggagcgg ctgtgagcac gccggccgag
    14461 gctgaggacc gagccatgcc gggtggccgg caggcagccc cggaacgcga gcgtgtttgc
    14521 ccgccgcctc ccggccgccc tggtcacgga cgtccccgac cacgtcaggg acgtggtcgg
    14581 cgagcgtgac cagcaggcgt gaccggcgag cgtgaccagc aggcgtgacc ggcggacagg
    14641 atcggcggac aggatcggcg gacggggtcg gcggagggca cggtggcgcc aagggccgga
    14701 gcccatggcg tgttccgaag tggcctcggc caccgcgcgg gcgcgtggct gagcggtggg
    14761 gccgacgccg gaggcgaggc cccaccgcga agatcgcgaa gcgatgccgc gcccgccaag
    14821 gcacggtcac cccccgagcc gccaggcgag gggggtgggc cgggtcttca tgagaacagc
    14881 cgggacttta cgagtacagc cagggggcct agggcgtttc tgatggatca tcagggcgac
    14941 cttgcgggtc ctggaacggc tccacaaacc acctctcggc gacctgctgc cacagcagca
    15001 acaaccacgt tgctcgttgg gtccgcccaa gattcatcag aagcgcccta gctgacgccc
    15061 gcctccttca tttcgcggag ttcgcgcttg agttccttga tctcgtcgcg gaggcgggcg
    15121 gccagctcga actggaggtc ggtggcggcc tggtgcatct gggcggtcat ctgctcgatg
    15181 aggccctcca gctcctcgcg ggggcgctcg ccgacgaggt cggcggcgtg gcggcccacc
    15241 tcgcgggtgc gggaggcgag gccgggcacg ggcgccttgc cgcggctctg ctggcggccc
    15301 gcgccgccga tgagggtctc ggtgtcggcg tcctcgcggg cgagggagtc gaggatgtcg
    15361 gcgatgcgct tgcgcagcgc ctggggctcg atgccgtgct cggtgttgta ggcctgctgc
    15421 ttggcgcggc gccggttggt ctcgtcgatc gcgcgctcca tcgacggggt gacggtgtcg
    15481 gcgtacatgt ggacctggcc ggagacgttg cgggccgcgc ggccgatcgt ctggatgagg
    15541 gaggtctccg agcgcaggaa gccctccttg tcggcgtcca ggatcgcgac cagggagacc
    15601 tcggggaggt cgaggccctc gcgcagcagg ttgatgccga ccagcacgtc gaactcgccg
    15661 gcgcgcagct cgcgcagcag ctcgatgcgg cgcagcgtgt cgacctcgct gtgcaggtag
    15721 cggacctgga tgccgagttc gaggaggtag tcggtgaggt cctcggacat cttcttggtg
    15781 agcgtggtga ccaggacgcg ctcgtccttg tcggtgcgca gccggatctc gtggatgagg
    15841 tcgtcgatct ggcccttggt gggcttgacg acgatctcgg ggtcgatcag gccggtgggg
    15901 cggatgacct gctcgaccac gtcgccgccg acgcgggtca tctcgtagtt gccgggcgtc
    15961 gcggacaggt agacggtctg cccgatgcgc tccaggaact cctcccactt cagcggccgg
    16021 ttgtcgatcg ccgagggcag ccggaacccg tgctcgacca gcatccgctt gcgggacgcg
    16081 tcgccctcgt acatcgcgcc gatctgcggg acggtctggt gcgactcgtc gatgacgagg
    16141 aggaagtcct cggggaagta gtccaggagg gtgttggggg cggtcccggc gccgcggccg
    16201 tcgatgtggc gggagtagtt ctcgatgccc gagcaggtgc cgacctgccg catcatctcg
    16261 acgtcgtagg tggtgcgcat gcgcagccgc tgcgcctcca gcagcttgcc ctgccgctcc
    16321 atgacggcga gcgtctcctc cagctcggcc tcgatgccgg cgatggcccg ctccatccgc
    16381 tcggggccgg cgacgtagtg ggaggcgggg aagacgtaca gctcgtcgtc ctcggtgatg
    16441 acctcgccgg tgagggggtg cagggtggcg agcttctcga tctcgtcgcc gaacatctcg
    16501 atccggacgg cgagctcctc gtactgcggg atgatctcga cggtgtcgcc gcggacgcgg
    16561 aaggtgccgc gcgtgaacgc caggtcgttg cgggtgtact gcatgccgac cagctggcgg
    16621 aggaggtcgt cgcgctcgat ccgctgcccg gtctggagcc gcaccatccg gtcgacgtac
    16681 tcctgcgggg tgccgaggcc gtagatgcac gacaccgagg cgacgacgac ggtgtcgcgg
    16741 cgggtcagca gcgagttggt cgccgagtgc cgcagccggt cgacctcgtc gttgatcgag
    16801 gagtccttct cgatgtaggt gtcggtctgc gggatgtagg cctcgggctg gtagtagtcg
    16861 tagtaggaga cgaagtactc caccgcgttg ccgggcatca tctcgcgcag ctcgttggcg
    16921 aactgggcgg cgagcgtctt gttcggctgc atcaccagga cgggccgctg gagcttctcg
    16981 accagccacg cgatcgtggc ggtcttgccg gtgccggtgg cgccgagcag taccgcgtcc
    17041 ttgtcgccgc ggccgatccg ctcggccagc tcgctgatcg cctgcggctg gtcgccggac
    17101 ggcgtcatct cggtgacgac ctcgaagggc gccacccggc gccgaagatc ggtgactggc
    17161 cgcatcccgg cccccctccc ctgtgactac tcccccactg tacgcacggc gtccgacaaa
    17221 ccggtccacg ctggtcagcg ggccggacgg cgatcaggac gcgggcagcg gcagccgcgc
    17281 ccggacggcg tacccgccgt ccgcgctggg cccggcctcg aagctgccgc cgagcgcggt
    17341 gacccgctcg cgcagcccca ccaggccgtg cccgccgctc ggcaggccgt ggtcgggcgg
    17401 ggcggtgggc gcgtcgttgg cgatctcgac ctcgacggcc tcggggagca gcccgaggcc
    17461 gacgcgggtg tcggcggcgc ccgcgtgctt gtggacgttg gtcagcgcct cctggacgag
    17521 ccggtagacc gtccgcccga cggcgggcgg catgggccgc tcctcgccgc gcacggccag
    17581 gtcgaccacc aggcccgccg cccccgactg gtcgaccagc tcgcggacgt gggcgagcgt
    17641 caccgcctcc tggggcagcg cctcctcgcc ctggcgcagg acgccgatca cgtgccggag
    17701 ctcctccagc gcctgccgtc ccatgtcgcc gatgacggtg gcggtctcgg cggcccggcc
    17761 cgggtcgcgg acggcgatcg ccttcagggc gcccgcgtgg acgaccatga cgctgatccg
    17821 gttggcgacg acgtcgtgca tctcgcgggc gatgcgggtg cgctcctcgc cccgcgcgcg
    17881 ctccgcgagg aggtgctgct cgcgctccag ccgggacgcc cgctcctgga gggaagccag
    17941 tagttgcttg cgggccccca tatagaggcc cagcaggatg gggacggccg tgaacgccac
    18001 cccgaagatc gcctgggcga ggaacgggtc gtcgctctcg gtggggccgg ggaaggcgat
    18061 cccggagacg tacccgaagg cggcgatcgt ccacaccgtc cggcggttgg gggtgtaggc
    18121 ggccagcgag tagaggatca ccaccagcgc gaacacgccc gcgcccgcga ccgtgccgag
    18181 cgccacggcg acgagcgcga gccggaccgg gtgccgcctg cggaagacca ggcccaggcc
    18241 gaggaggaag ctgccgaccg acgtcacggc gggcggcagc cagaagtcct gaggggcgaa
    18301 ccacaggaac acgccgtcca cgaccgccag cgacaccgcg agggtgaggt ccagcgcccg
    18361 tgaacgcggt gtcggccatg ccgccgacca ccagccccgc agctgcatgc gatgagtgta
    18421 gggggcggag gggaccaagg tcgtccatgc cggaaagcgt ggtcgtccgc ggcccgaggg
    18481 gaacgtgacc tgcggcgcct cagccccggc cgcgtagggg acgcgggccg gtggcccccc
    18541 tcgcggtgct gtggttacga tgacggcgcc gacaaggacg gggaaaacgc atacaatgac
    18601 ccgcttcgcc acgtggctcg ggaagaacgc cgacgccttc atcgcgctga tcctcgccat
    18661 cacggtcgcg gtgctcgggg tcggggtgga cctcccccac gaggacgagg tcaccaacag
    18721 cgcgatcctc gcggtggtcg gcctcctggc gacgtcggtg ctgcgggacc gggggcggcg
    18781 cgtcccggtc gaggcggagg tgcgcgacac gctgcgggcg tcctcggcca cgctggacga
    18841 gctgagcggc aagctgaccc acatcgagac gttcgagggc gtgctggccg acaccaagcg
    18901 cgcgctggac gagaccacga tcgtccgggt gatcagcggc gcgcaggtgg cgcaggtgct
    18961 ggaggaggcg cgccgcgaca ccgaccgctg gatcttcaag ggcggcaccg gcacctacat
    19021 ccgcgccaag acgctgcccg agaccgtcgc cgccgcccgc cgggacggcc ggacgctgct
    19081 gttccggctg gagatcatcg acccgacgga cgtcgaggtc tgcgaggcct acgcgcggca
    19141 ccgccgctcc tcggcggacg ggcccgacgg caccggcgag ccgtggacgc tggagcgcac
    19201 ccgcaaggag gcctacgcca cgatcctcgc ggcgtgctgg cacaagcagc ggttcgggat
    19261 gctcgacatc gacatcgggc tggcgcggac gatgacgacg ctgcgctacg acctgtcgtc
    19321 ctcgctgatc gtggtcaccc gcgacaaccc gcgcggccag gcgctggtgg tcgacagcac
    19381 gaagttctac tacagctggc tgagcgcgga gctgctgacg agcctggacc aggcgcgccg
    19441 cgtgccggtc gagcaggcgc ggttggcgcc gctggacgat gagccgaccg tcgaggaggt
    19501 ccgcaggctc ttcgaggtga tcggcatcga catggcccag ggctacaccg accgggacgt
    19561 catcgagatc atcaggaagg cgctgcggcc caaggacccc tacgagtgac cgcgtccgcg
    19621 cgggcaggac gcacgcggac gccacaaagg aacagcgaca tcgggtgcga gcgatgaggt
    19681 acgaggagat ccgcagggag atcgaggccg ggacggcggc gcggacgctc ccggcgtggg
    19741 cgggccgcgt cctggcggac gtcgcggagg ggcggtcccg cgtcccggcc gtgcggcatc
    19801 ccctggggtt cctgtgcctg ccggtggagc gcgccggcga cttcggcgtg tgcctgcaca
    19861 tctggacgtc cgaggtcgac ccggcgccct ccaccacctc gcccgtgcac tgccacagct
    19921 gggacctgct gagcttcgtc ctgtacggga cggtgcgcaa cgtccggatg gacgtcggcg
    19981 agggccccgg cggggcggcg gcgcaggtct tcgaggtcgt cagccggggc gaggtcgacg
    20041 agctgagggc caccgggcgc accgtccgat actctcccgg ccgttccacc gcccacggga
    20101 cgggcgagtc gtacactctg cccgcgggcg tgttccacag cacgctgatc gaggacgggc
    20161 gggacgcggc cacggtcgcg ctcggccgcc agacgcccgg gggcggcgac ctgtcgctcg
    20221 gcccgccgga cgtcgcgacc caccgggtgc gccgcgcgcg gtccgacccc ggcgaggcgg
    20281 cgcgcgccct ccaccggtcg gcccgcgagg tcgcgaacgc atacgccgct cgtcccgcgc
    20341 cgcccgggcc gggacgcccc cgcgacgacc tgtcaccgac gcgccggtag gcggccgccg
    20401 gaccccgagc ccccggaccc gactggagag gcccccgatg agatccacga cagcgtcacc
    20461 ggccctaccg gtcgatctcg gcgaggcccg ccgggtggcg gtcgatgcgg ccgaggcggc
    20521 gggggcgctg ctgcgcgccg gcacgggcgg cccgctggtc gcccggccca agggcgggaa
    20581 cggcgacgtc gtcaccgagc tggacaccgc cgccgaggag ctgatcctcg ggcggctgcg
    20641 cgccgcctac cccgggcacc ggatcatcgc cgaggagtcg ggggtgctcg acggcgcgga
    20701 cggctcccac ctcgtctggc tggtcgaccc cctcgacggc accaacaacg tcgcgatcgg
    20761 catgcccgtg tacgcggtgg ggctggcgct gtgcgcgggc tccgtcccgg tgctgggcgt
    20821 cgtccacgac cccgtctcgg ggcggacgtg gacggcggtg cgcggcgagg gcgcgctcga
    20881 ccccgacggc gccccgctga cgctggcgcc gcgcccgcgc cccggccggg agcgcaaccc
    20941 ggtgctgggc tggacgcagg gccacgcggt caaggcgggc gacccgtcgg cgctggcgct
    21001 gcgcacggcg ctggagctgc gctgctcgcg gctcctccag ctgtgggcgc cgctggtcgc
    21061 gtgggcgatg ctggcgcgcg gcgacatcga cggcatcgtc ggctaccggc ccgagctcgt
    21121 cgacctgccg ccgggcgcgc tgctggcggc cgaggcgggc gctgagctgc gccgcctgga
    21181 cggcggcccc tacgagctga gcatcgaccg cacgccgtcg gagctggggt tcgtggcggc
    21241 ccgtccggag ctgctcgcgc ggctcgtgga gaccgcgaac cgcgcgctgg acaccgccgg
    21301 gccggacggc cagatcccgc tcgtccggta gtcagcgggt cgccggcaat gccgcgatgg
    21361 cggcggcgca gcccagtacg gccaggacgg tcccggtgag gacgaacttg cgcatgggga
    21421 cgcgcacgtc ccagcggcgg caccactcga accacagcag cgtcgccagc gacccccacg
    21481 gcgtgatcac cgggcccacg ttcgtgccga tgagcaggga cagcagctgg tcccggttgg
    21541 cctcggggac cgccgactcc cccgcgacgt aggcgggcag gttgttgagg acgttggaga
    21601 gccccgcccc cgcgaacccg gccctgacgg cgcccgcggc gccgtcgtcg ccgccgacga
    21661 gggagcgcat cacctcgtcc agcccgtacc gctcaagggt cgggacgacc aggaacagcc
    21721 cggtcacgaa caccatcagc cgccacggca ccagctcgcc ccgcagcgcc gaccggtcgc
    21781 ggacggcgaa cgcggccacc gccacgacgg cggcggcggt cgcggcgagg ccgagctgga
    21841 ggccggtgtg gacgcccgcg aggatcgcgc cgatgaacag caggcacgcg gcgcccgtcg
    21901 cggagaacag gacgcggtcg cggacgggcg cgacgtccgg cgggtcgtag gtgtcggcgc
    21961 cgcgcatgcc gcgccgccag aagaacgccc acagcagcag catggtgacg gcgaggacgg
    22021 cgacctgcgg cagccacatc cgggcggcga acgcgggggt ctccagggcc acccggtcgg
    22081 cggcgaggag gttggtcagg ttggacacgg gcagcagcag gctcgcggtg ttggccagcc
    22141 acacggtcgt catggcgagc ggcagcgcgg cgatccgcgc gcgcgccgcg agcgccagca
    22201 tgaccggcgt cagcagcacg gcggtcgtgt ccaggttcag gaagacggtg gtggccgccg
    22261 cgaaccccac gcacagcagg aacagcgcgg cgtagttgcc ccggcccgcg ctcgccatcc
    22321 gctgggcgat cgcgtcgaag accccggcct ccttggtcag ctccgccagc acgatgacgc
    22381 tgagcaggaa cagcagcagc ggcgcgatgc gctcgacgct gtcgcgggcc gtcgcgggcg
    22441 ggagcaggcc cgtcgcgacg aagaccagcc cgagggccag cagccccacc ctgacgcggt
    22501 ccaggaggcc catggaccgg acggctcggc gcagggtcgc gggcggggac ggcacgcgcg
    22561 acatg
//
