LOCUS       NZ_WOFH01000002        26066 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Actinomadura litoris strain NEAU-AAG5 Scaffold2, whole genome
            shotgun sequence.
ACCESSION   NZ_WOFH01000002
VERSION     NZ_WOFH01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura litoris
  ORGANISM  Actinomadura litoris
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 842719)
  AUTHORS   Cao,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2019) Northeast Agricultural University, College
            of Life Science, No. 600 Changjiang Road, Harbin, Hei Longjiang
            150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 109x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009733595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 03:46:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,194
            CDSs (total)                      :: 8,115
            Genes (coding)                    :: 8,044
            CDSs (with protein)               :: 8,044
            Genes (RNA)                       :: 79
            rRNAs                             :: 5, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 1 (5S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 14 of 71
            Pseudo Genes (incomplete)         :: 60 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:00:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 414606
            Orig. end                         :: 440672
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WOFH01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26066
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26066
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26066
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16066](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16066)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(400..561)
                     /locus_tag="GNZ18_RS40740"
     CDS             complement(400..561)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS40740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_173390667.1"
                     /transl_table=11
                     /translation="MNQRNSTLSRHVTSEGTVIWSRCACGRLRMDLVPHGSAPRLTAGP
                     CAHGHPPK"
     misc_feature    587..602
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     misc_feature    619..635
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.51"
                     /tool="antismash"
     misc_feature    619..635
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.85"
                     /tool="antismash"
     gene            634..1587
                     /locus_tag="GNZ18_RS06385"
                     /old_locus_tag="GNZ18_06395"
     CDS             634..1587
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077754.1"
                     /locus_tag="GNZ18_RS06385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06395"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_214618868.1"
                     /transl_table=11
                     /translation="MIDLRRLHLLRLVHQYGTVTAAAEAMHLTPSAVSHHLRELARELG
                     VVLLEPQGRRVRLTPAAHLLIGHADALHARWEEALSDLESHRAGAAGPLRMCGFTTAVS
                     GLIAPAAGRLTAADPDLAIEIRECDTDVAMGLLAAGETDLAVIEPTPEAPPPGDPRFDR
                     EPLLEEALDLIVPVGHPLARRGTAVLEDAASEAWISVEPDGCAHHQQVMTYCAAAGFTP
                     RIAHNATTWSVIWALVANGLGVSLVPRLADGQSGQTVVRVPLTGDSVPKRRVLTCVRRG
                     SRTHPLIARGLAALHEAVPAQCDLLPAATRAVPVAS"
     gene            complement(1591..4131)
                     /locus_tag="GNZ18_RS06390"
                     /old_locus_tag="GNZ18_06400"
     CDS             complement(1591..4131)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024116.5"
                     /locus_tag="GNZ18_RS06390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06400"
                     /product="ABC transporter permease"
                     /protein_id="WP_173390668.1"
                     /transl_table=11
                     /translation="MVKLVFRGLAAHRARLLLSVVAVVAGVAFVSGTLIFSATLSRSFD
                     RAFDDLGRGTDTVVRARQSFRTGPGERAAPRPVPASALAAVRRAPGVAKAEGVITGFAA
                     AVDRQGRIAGAEPQTGVAWSGDRDLSLTRLTAGAPPRAPDEVAMDATTARDARYRVGDR
                     VTVALRSGTRTFRLTGLFRVGDSALGSSISMTAFAPDAAPRLLGQRPGTYERIVVHADG
                     GVTQERLRDAVAAVLPPGVEAVTGAEAAAEQAGPLKDIIKIMRTFLLVFALIAVFVGSF
                     IIFNTFAMLVGGRVRELALLRAVGASRGQVTRSILGEAAGVGLAGSTLGLAAGAVVALG
                     LARLMTLVTGGEELPFGPLALPASAVLAAYLVGTPVALAAAFVPARRAARIPPVAALRE
                     DAAPPRPLRRRALGGCAVLAVGGILAAAGLAGDGTSGLTLAGTGAALLFAGVVVVSPAL
                     SRPVARVLARPFARFGGGAGRMGARNAVRDPRQTSATASALTIGLALIATVSIIVQSLA
                     ASVDRQLEAALTADYQVTGRSQVTPVEAGAAAAVGRVPGVRAAIPVRTARFRLEGAVQA
                     ATAGSPGELLAHFRLPLQQGSAAVRGEDLLVGRSVARDRGWRIGGTIPGEYQDGTRRTF
                     RIAGIYADRPALTPSAPTVIIDWAGYRAHDPDAPIERIEVTVAGARRAALESALAPWPN
                     LELKDRAQVKDDAAGEIDLFLTLVLGLLVLSVLVAALGIVNTLALAVTERTREIGLLRA
                     VGTQRRQLRRMIRYEAVVVSLFGAVLGVGTGSVLGVVLQKAIAGGEDGMEVLAVPYGRL
                     ALCVAAAAAIGVVAAVWPAARAARLDILQAIATD"
     misc_feature    complement(4113..4127)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.72"
                     /tool="antismash"
     gene            4276..5562
                     /locus_tag="GNZ18_RS43555"
                     /old_locus_tag="GNZ18_06405"
     CDS             4276..5562
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="GNZ18_RS43555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06405"
                     /product="sensor histidine kinase"
                     /protein_id="WP_216651179.1"
                     /transl_table=11
                     /translation="MRLTPPPAPPGRDLAADAVAVVCALALSLQTAAGPDSVLRGHHGA
                     TAAVVALPALALAVRRRFPMTVAWLTAAVAALLDAVERLAPGTLLRDGPPGAFDPIVWW
                     PPALPFAVYAAMAFPRDGDRPVWARALPVLALVPLVGLTQDVIPDESIRRVSGQETSSV
                     ETMVFRSMAMLVAAALLGMYVAARRRVLQGLTERAERAERERHLLAERARAEERARLAA
                     EMHDVVAHRVTLMVLRAGALRVRAPDEETRAAAEELRDDGCHALEELRDVIGLLRRGAG
                     AAGAAPAPASGPLPDLSELVAESAAVGVRVELVERGEPAPASPAVGRTAYRVVQEALTN
                     ARKHAPGAAVRVEVGYRSDGVRLSVLCAAPERDPDAALAASGSGTGLAGLRERVETVGG
                     TFSAGPAGDGFRVEASLPAYVPLPTPPAP"
     gene            complement(5529..6032)
                     /locus_tag="GNZ18_RS06400"
                     /old_locus_tag="GNZ18_06410"
     CDS             complement(5529..6032)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019656.5"
                     /locus_tag="GNZ18_RS06400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06410"
                     /product="DUF1707 domain-containing protein"
                     /protein_id="WP_156215239.1"
                     /transl_table=11
                     /translation="MTTPEGIRSGDVRVGDAERDAVMVALHDHFAAGRLDREELDERLG
                     TTLAARTRGDLRAVVLDLPDPQGLAVPEAAPARHHRGRPHHLGHHHLGRHHHGRHRHGP
                     PFPLLLGLFLVLAFTMGPGPGFLVVLQVALAVWAVRALLMALGHRHLRHHAHRQGAGGV
                     GRGT"
     gene            complement(6029..6811)
                     /locus_tag="GNZ18_RS06405"
                     /old_locus_tag="GNZ18_06415"
     CDS             complement(6029..6811)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631347.1"
                     /locus_tag="GNZ18_RS06405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06415"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_156215240.1"
                     /transl_table=11
                     /translation="MGATHRSGPDWRWAFAAAAIGAKAAHAASRHGHGHEHGFGPGHGH
                     GHGHEHAHGGPWQWGPPGGFGPGGGRPPWARGGGRGPWGRGRKAPKGNVRAAILALLAE
                     EPRNGYQIIQEINERSGEAWKPSPGAVYPALQQLADEGLITAEEGGGRRTYRLTAEGGA
                     YVAEHADELEEPWAQMAPDFGEGAPELFRQVAQTGAAVMQIVHSGTPDQVRRATEILSE
                     TRRALYRVLAGEEPRAGGADAGPTAEGPTAQGPGEEPA"
     misc_feature    complement(6950..6970)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            7000..8985
                     /locus_tag="GNZ18_RS06410"
                     /old_locus_tag="GNZ18_06420"
     CDS             7000..8985
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025736.5"
                     /locus_tag="GNZ18_RS06410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06420"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_156215242.1"
                     /transl_table=11
                     /translation="MGTDEAMTAPDAVVTGGGAVARGRLRGELLLGMAVFGLYALVVML
                     PQDARERAARGHGRALYDLERALRLDVERTLNGWLAGQPVWRVLANYEYAITYIASAVA
                     LLAWLYLRHPERYRTARNAFLLINLVGIACFALYPVMPPRLMPELGFVDTVRLGRTWGS
                     WGSPMVEHADRFAAVPSLHMAWTLWVGVELARVSARRWVQSVNAVHILLTLYVIMATAN
                     HYLLDALAAVPLVGFAVYAAERATPRGAGERVRGPDAFFLAVETPEAPQHAGGLIVLDT
                     ARAPVTRDDLAALVAARLEDHPRFRQRLADGGRWRRPLWRDDPAIDWAWHVQERRVDGM
                     AGLRAVVAAIQSEPLPRDRPLWRMILVTGVAPGRDAVVFLMHHVVADGVGVVAHAMALM
                     EPYPLDYGGTGRRRRPVQEALATATGLGQLAADAARPARLPAAGTSERRFGTLLVPLDQ
                     ARDVARRHGARVTDVVLCAVAGGLHRVLRETPGAGDSCRVAVPLMMRSPGDGAEGNHTS
                     AVMIDLPIGKMPEADRLAETARRARVLRSGTRPLAAWFVMRQAGRVMPAPLHARFARYA
                     YSARFLQGIVSSLPGPDRLLRLAGAPLLEVYPVIPLAPGAPLAAGALGVDRDLCFGVCA
                     DPGLVDDADRMTAAVAEVVRELREAD"
     gene            complement(8996..10000)
                     /gene="hpnH"
                     /locus_tag="GNZ18_RS06415"
                     /old_locus_tag="GNZ18_06425"
     CDS             complement(8996..10000)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540959.1"
                     /locus_tag="GNZ18_RS06415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06425"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_156215244.1"
                     /sec_met_domain="PF04055 (E-value: 7.9e-19, bitscore: 64.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 6.2e-09, bitscore: 31.1,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGMPLRQSLRVGGYILRNRLARRAKFPLLVELEPLYACNLACAGC
                     GKIQHPASLLKQRMPVEQAVAAVRESGAPMVSIAGGEPLMHPGIGEMVAELVKMKRYVF
                     LCTNAALIPKKIDLFEPSRYFAWAVHVDGLRERHDASVCKDGVFDQVVEAIAMCRERGF
                     RVTTNTTVFNTDTPQTVIDVLDYLNDDLGVDQMMISPAYAYEKAPDQEHFLGVQETREL
                     FRKVFADGRRRRWRFNHSPLFLDFLEGRADFPCTAWAIPSYSLKGWQRPCYLMDDGYAD
                     TYEELVRTTNWGAYGRGRDDRCSNCMAHCGYEPTAVFATIGSLTESLRAIRSG"
     misc_feature    9994..10010
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.52"
                     /tool="antismash"
     gene            complement(10001..11884)
                     /gene="shc"
                     /locus_tag="GNZ18_RS06420"
                     /old_locus_tag="GNZ18_06430"
     CDS             complement(10001..11884)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01507.1"
                     /locus_tag="GNZ18_RS06420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06430"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_156215246.1"
                     /sec_met_domain="T2TS (E-value: 1.1e-143, bitscore: 475.1,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTAEPAAPSTREAARKTLDAAREHLLGLQSPEGWWKGELQTNV
                     TMDAEDLLLREFLGVRDEEETREAARWIRSQQREDGTWANFFGGPPDLSTTVEAYVALR
                     LAGDPTGADHMRRAAAYVREAGGLPATRVFTRYWLALFGRWPWDALPVVPPEMIYLPSW
                     FPLNVYDFGCWARQTIVPLTVAAALRPVRPLPFDIAELHGQHVRRRRQGPPGWAEAFHA
                     LDRALRVYQRRPVKAVRRAALRRAAEWIIARQEPDGSWGGIQPPWVYSLIALNLLGHDV
                     DHPVMRRGLQGLERFTIRDGQGRRLEACQSPVWDTALAMTALADAGMPAGHPALEKAAA
                     WVVGEEVKGPGDWQVRRPGLPPGGWSFEFDNDYYPDVDDTAEVVLALGRVAHPDAPPAV
                     ERGLRWMAGMVSRDDGFGAFDADNTRELCRRLPFCDFGEVIDPPSADVTAHVVEALCAQ
                     GMGDSQLCKRAVVWLLKAQEQDGSWYGRWGANHVYGTGAVVPALIAAGVRPGKPVIRRA
                     VAWLERHQRDDGGWGEDLRSYRDPAWIGRGASTPSQTAWALLALLAAGERGPAVERGVG
                     WLTERQRPDGTWDEDHFTGTGFPGYFYINYHLYRLVFPVSALGRYLREDAS"
     gene            complement(11884..12876)
                     /locus_tag="GNZ18_RS06425"
                     /old_locus_tag="GNZ18_06435"
     CDS             complement(11884..12876)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634145.1"
                     /locus_tag="GNZ18_RS06425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06435"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_156215626.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3e-62, bitscore:
                     205.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVRELVDGALRAAVGRLDPHTYRVAAYHLGWADAEGRPRKEPA
                     GKALRPALALLSARAAGAPPESALPGAVAVELTHAFSLLHDDIMDGDRTRRHRPAAWAV
                     YGEPAAILAGDALLALAGEVLLEAPGQGSARAARALAVATRHLIAGQSLDLSFETRHKI
                     TLEECQSMAAGKTAALLACSCSIGAVLDGAPEGLAAALEGFGADLGVAFQLTDDLLGIW
                     GDPAATGKPALSDLRSRKMSLPVVAALNSGTPASAALAELYARPEPPGEDELAEAARLV
                     DLAGGRAWARAEAARRVESAGEHLAGAGVPTPVRTEFLRVADFVTHRDH"
     misc_feature    12893..12908
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(12894..14216)
                     /gene="hpnE"
                     /locus_tag="GNZ18_RS06430"
                     /old_locus_tag="GNZ18_06440"
     CDS             complement(12894..14216)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634146.1"
                     /locus_tag="GNZ18_RS06430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06440"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_312874330.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.1e-08, bitscore:
                     29.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 3.9e-11, bitscore: 38.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVVVVGGGLAGISAALALQEAGADVTLVEARPWLGGATHSFGRG
                     DLTVDNGQHVALRCCTAYQGLLQRLGTDHLLDVQRRFDVTVLRPGGAPARLRRAPLPSP
                     LHLLPALARYAPLSAAERLRAVWAAARIRSLDPADPVLDGVAAGTWLAERGQRPWAREA
                     LWGLFVTAALNAEVDDAALGLSAMVCRRALFGRADAADIGVPSVPLADLHGGPALARIE
                     EAGGTVLLKAKVEAVTADPKVIVDGAPIAADAVVMAVPHEAAARLLPAEALPDPLRWPE
                     LGASPIVNVHVVYDRPVLGLPFVAAVGSPVQWAFDRTVVGGLRGDGQYLAVSLSAADRW
                     IDVPTARLRERFTRELRRLLPAARHASVTDFFVTRERRATFRQRPGSGAARPGAATRAP
                     GLFLAGAWTDTGWPDTMEGAVRSGLTAARLVRRHLEGVRGR"
     gene            complement(14230..15147)
                     /gene="hpnD"
                     /locus_tag="GNZ18_RS06435"
                     /old_locus_tag="GNZ18_06445"
     CDS             complement(14230..15147)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540950.1"
                     /locus_tag="GNZ18_RS06435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06445"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_156215248.1"
                     /sec_met_domain="phytoene_synt (E-value: 4.4e-59, bitscore:
                     195.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.1e-65,
                     bitscore: 215.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSETCERPEWVVEAYRHCERVVREEARNFGYGIRLMPAPKRRA
                     MSAIYAFARGVDDIGDGPEPACVRMDLLDRARGRLETVQEVLWRRADSRALEGHPVLTA
                     LADAAGRYPIPLDAFAELIDGCESDVRGAAYETFDDLLRYCQQVAGTVGRLSLGVFGYD
                     GRQRAEGLADSLGVAFQLTNILRDVREDRLAGRVYLPAEDLDRFGCTLELDETGEFVDP
                     ASRLHDLVAFQAERARAWYAEGLRLLPLLDRRSAACTAAMAGIYRRLLERIAESPALAL
                     TSRVSLPTWQKAVVAARALTGVER"
     misc_feature    15137..15148
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.92"
                     /tool="antismash"
     gene            complement(15203..16066)
                     /gene="hpnC"
                     /locus_tag="GNZ18_RS06440"
                     /old_locus_tag="GNZ18_06450"
     CDS             complement(15203..16066)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634148.1"
                     /locus_tag="GNZ18_RS06440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06450"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_312874331.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.6e-42,
                     bitscore: 141.2, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 1.2e-40, bitscore:
                     134.9, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEPPWSAREHERGLDALARRENFPVAARLLPGRHRAHLRAVYG
                     FARLVDDIGDEAPGAHRVALLDSVDADLDLLYKGRAPVLPQLRRLAETVHARGIPQEPF
                     RRLVQANRRDQEVTRYASFDELLGYCVLSANPVGRIVLHVFGAEGRGLEEASDRVCTAL
                     QVIEHCQDVAEDFRAGRIYLPGEDLRRFGCAEDDLSRAVTPTRLRGVLALESNRARDLL
                     DRGAAPLMAGLRGWARIAVAGYVAGGRAALAALVRGRYDVLARTPRPRGPVLLANWASA
                     LGGGRR"
     misc_feature    complement(15806..15808)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16172..16186
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.84"
                     /tool="antismash"
     misc_feature    complement(16176..16189)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.14"
                     /tool="antismash"
     gene            complement(16210..17142)
                     /locus_tag="GNZ18_RS06445"
                     /old_locus_tag="GNZ18_06455"
     CDS             complement(16210..17142)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016533.5"
                     /locus_tag="GNZ18_RS06445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06455"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_156215250.1"
                     /sec_met_domain="APH (E-value: 4.5e-09, bitscore: 32.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPILPGPLPSVLVENAVEVWGDDGRRWLKRLPGLLAEIAREWRL
                     EIEAARYGLSYHWVAPVRREDGTKAVLKLGPPEPGHLGIEAAALEIYGGEGAVRLLEHD
                     PGRGALLLERAEPGRVLSELVPDKDEEATAVFLDVARRLRHVPPPGCALPGLEKESASF
                     SGHLRRFPGDGPLPRHLVERAGRLFDELCASAPERLVLHGDLHHDNILSAEREPWLAID
                     PHGVVGDPGYEAGVLFYNPGPDDRDGRLVDLVPARIEQVADGLAMPVERVVAWGFVMAV
                     LSEVWTAQGDGTPGSRALDVALSLVGRLP"
     gene            17200..20760
                     /locus_tag="GNZ18_RS06450"
                     /old_locus_tag="GNZ18_06460"
     CDS             17200..20760
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019334.5"
                     /locus_tag="GNZ18_RS06450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06460"
                     /product="WD40 repeat domain-containing serine/threonine
                     protein kinase"
                     /protein_id="WP_156215251.1"
                     /sec_met_domain="Pkinase (E-value: 2.4e-40, bitscore:
                     134.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPLVPGDPRELGDYWLARRLGAGGQGVVYEAYGADGARVAVKA
                     LHGVFAGERAGGPRDVLAREIDAVTRVSPFCTARVLAFDLDAEPPYVVSEYVPGPDLER
                     AVASGGPFGSGELGRLAIGVATALVAIHRGGVVHRDLKPGNVLLGPDGPRVIDFGLARA
                     EDMTRSATGAKGTPRYMSPEVFAGEPASAASDVWAWGAVVLFGALGRPPFAGENLMQLS
                     HTVQHVEPELHVLDEPLRSVVAAALAKRPRDRPSAREVLLDLLGGSFDEGAMLSEGSRV
                     AAAAAAGAAPPSLADVAEAAYRRLDPLAREAVPAILLRMVLPGEGAADTLRRAAVDEFG
                     DGAERAVEEFTRAGLLVREGDRVAICGAALLRAWPRLRGWVDDERAGLAVHRSLADAAR
                     VWDRHGRRAGDLLQGSVLARAVQWAATGRRHLTLNAVERAFLDASAALGRRRARSRGAL
                     TAALAVLLVVAVGGAVVAVNQRAVLSRQRDRAIADRLAALAASLQRDDPRTSRRLALAA
                     ARVGDDDQTRKALINAMYQWEGDTFNPASNAQVVLTPDGRTATFDDRVQVTRWDLKTHQ
                     RVPMPPGAEPKSAAVFSPDGRHMAQLLSTGGDLSRRGVVQVYDAATGKPQGRPMGDPRQ
                     SFWNLRYSVSGNLLMMDNGPGGSGDPRTTAPEMALWDARSGRLAMSWKERPYAWAVSAD
                     DALVAMVLPSGFQLWDVAARKRIPTPWLGAALASESASQRIRQVGFGPAGARLALVAGS
                     GVTVLDLNNLARTEPVASRSRVPWHERSARGVDEPVFSPDGRLLAVGFTLWNLDGSAEA
                     PLMARGLDDETPTDCRFSAAGDLLRCATTLDRVVTTNISGYADRISVGRDAGHGVLSPS
                     GDLLASMGADSVSITGNPAGWTSPFSVPSLRSVWRGMVFSPDGGLVAIPDRNPDDGFGV
                     WDARTLQKVAELDWPDGALGKGVAFSPDGRSLVGGLNAEVIDPRHPYKSWLQEWDARSG
                     RRTRVIPLESSGSGELFYRSDGRTVTLKSAVVDMDSGQVHKRFDFFSVVDVLAVSPDGS
                     VALVIINPDNLYLWDLRGDKRRGTPLAAVPDVEDLPAAFSPDGRLVATSDARGGVHLYE
                     VATGRPYGPTLPGHAGGVDTFAFSRDGTVLYTYGGDRTIQATTLDPARLTDRLCAQVGG
                     LSEAEWNQYVPDLSYRPVCG"
     misc_feature    19006..19008
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19207..19209
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            21148..23013
                     /locus_tag="GNZ18_RS06455"
                     /old_locus_tag="GNZ18_06465"
     CDS             21148..23013
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00976.1"
                     /locus_tag="GNZ18_RS06455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06465"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_156215253.1"
                     /transl_table=11
                     /translation="MRARRRTTWANRRSRSWRLSLVAAAVVLLAGVAAPGAPADAAPKA
                     EVCEFSVQKDVPATMRDGTVLRSNVFTPKGDGKFPVILMRLPYNKEGALSFVYGAPDRY
                     AKACYLVVVQDVRGEYKSDGAFYPYRTEAEDGYDTIEWSAALPHSNGKVGMYGFSYPGL
                     TQWLPATLTPPHLVTIAPAFTSSDIYDGWTYEGGALYQAFIQDWLLSFLNGGVISKLPD
                     AAKLRAEMTQASRDLHTKWYRHQPLNNFPPLYPGDNRIAPYYFDWIDHPSDDDYWKRWS
                     IRTKYPRVNVPSLNFGGWSDIFLNGTVENFAGMRAQGGSEVARQGSQLLVGPWTHGGSG
                     RTVGAVDFGPEAVVAVGDLHLRWFDHWLKGIANGVDADPPVKVFVMGANKWRTADSWPI
                     PGTANTTYYLHSKGDANTANGGGTLDNTAPATGEKADQYQYDPANPVPSVGGRFQSSVP
                     GGPQDQRSVEQRRDVLVYSTPRLTKDTEVTGPISVTLYARSSAKDTDWTAKLTDVQPDG
                     TSMLVRDGIQRARYRVSLEKPELITPGEVYKYTIKLWPTSNVFKAGHRIRLEISSSNFP
                     MYDRNPNTGGKFGADTTTQPASQTVLHDPEHPSSITLPIIPVPVR"
     misc_feature    21166..21181
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.08"
                     /tool="antismash"
     gene            complement(23142..23789)
                     /locus_tag="GNZ18_RS06460"
                     /old_locus_tag="GNZ18_06470"
     CDS             complement(23142..23789)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017601542.1"
                     /locus_tag="GNZ18_RS06460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06470"
                     /product="response regulator transcription factor"
                     /protein_id="WP_156215255.1"
                     /transl_table=11
                     /translation="MSVRVLVADDQPIVRTGLTMLLDAQPGIEVVGAAADGREAVRLAL
                     RLRPDVGLFDIRMPLMDGIEATRRLAGPDVTDPLPIVVITTFDLDEYVYGALKAGARGF
                     LLKDAGPALLTQAIHAAADGDALIAPSVTVRLLAAFAHAQTPPRRQPIEPLTAREEEVL
                     VPVAQGRTNNEIAGELHITPSTVKAHVASLMRKLGARNRVEVAMWAHETGRI"
     gene            complement(23789..24937)
                     /locus_tag="GNZ18_RS06465"
                     /old_locus_tag="GNZ18_06475"
     CDS             complement(23789..24937)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017578697.1"
                     /locus_tag="GNZ18_RS06465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06475"
                     /product="sensor histidine kinase"
                     /protein_id="WP_156215257.1"
                     /transl_table=11
                     /translation="MATNALRSLWAEPRPAKAPALGPRDWALVAVLICWSVAEAVLRQD
                     LAPRPLLLLAVLAVLGPLLWRRTHPLVAVVVSCGTLTIIDVVRVLTGTQGALLNSGIAV
                     LILAYALFRWGSGREAASGLGVILLWPALITALGADPTTLAEVVAGYAFFLFAAALGTA
                     IRYRTKIRIRDIDHAKAREREQLARDLHDTVAHRVTGIAIQAQAGRAVAASHPERAVEA
                     LAVIEDAASRTLTELRAIVGVLRATQDAGFAPQPGVAEVEQLATDGRTRPCVKVTLSGE
                     FDDLSPAVGTAIYRLAQESVTNARRHARHASKVTVAVTGDADQVRLTVDDDGSAAGGRA
                     PAGYGLVGMRERASLLGGTFHAGPAAGRGWRVEAVLPRTGTP"
     gene            25095..25607
                     /locus_tag="GNZ18_RS06470"
                     /old_locus_tag="GNZ18_06480"
     CDS             25095..25607
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039408.4"
                     /locus_tag="GNZ18_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_06480"
                     /product="DUF6326 family protein"
                     /protein_id="WP_156215259.1"
                     /transl_table=11
                     /translation="MRTPQSQAAPENPSPQSTLEDLRLPVQAKLAAAWTSFMFLYIYVD
                     YLALYKPGFLDDLLGGTVHEFDTGPTFVAVALSLMAVPILMILLSATLPARVNRTINVV
                     VAALYIPVSVFNAAGEPLSYSYFYGLSIGLELLLLAFILRSAWSWPRRITSPATLATTL
                     DSEPQQA"
     misc_feature    complement(25798..25811)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
ORIGIN
        1 cccggttcct ggtcagcccc ggctgcacgc cccggctcca ggcggcgatg gtcgcgacgg
       61 gcctgccgtt cctgcccggc gtcgccaccg cgtccgaggc cgtcgcgctg ctggagggcg
      121 ggatcacggc gatgaagttc ttccccgccg aggcggcggg cggccgcgcc tacctgaagg
      181 cgctcggcgg cccgctgccg gacgcccggt tctgcccgac cggcggcgtc acccccggca
      241 acgccgccga ctacctcgcg ctgccgaacg tcggctgcgt cggcgggtcg tggctgacgc
      301 cgggcgacgc cgtccgcgcg ggcgactggg accggatccg cgcgctcgcc gccgacgccg
      361 ccgccctcgg gaagggctga cccctccgcc ggcgggcccc tacttcggcg ggtggccgtg
      421 ggcgcagggg ccggcggtga gccgcggggc cgagccgtgc gggacgaggt ccatccgcag
      481 ccgcccgcag gcgcagcggc tccagatgac ggttccttcg ctggtcacat ggcgggagag
      541 ggtgctgttc cgctggttca tgcgaccagt ctcccgccgc cgaacgtgcg cgtctatttc
      601 acgttttcgg atctgatcgt gcaatatgat gacatgattg atctgcggcg gctgcacctg
      661 ctccggctcg tccaccagta cgggacggtc acggcggcgg cggaggcgat gcacctcacg
      721 ccgtcggcgg tctcccacca cctgcgcgag ctggcgcggg agctgggggt ggtgctgctg
      781 gagccgcagg gccgccgggt gcggctcacc ccggcggcgc acctgctgat cgggcacgcg
      841 gacgcgctgc acgcccgctg ggaggaggcc ctctccgacc tggagtcgca ccgcgccggg
      901 gccgccgggc cgctgcgcat gtgcgggttc acgacggcgg tcagcgggct gatcgccccg
      961 gccgccggga ggctgacggc cgccgacccc gatctggcga tcgagatccg cgagtgcgac
     1021 accgacgtcg cgatgggcct gctcgccgcc ggggagaccg acctcgccgt gatcgagccc
     1081 accccggagg caccgccgcc cggcgacccg cgcttcgacc gggagccgct gctggaggag
     1141 gccctcgacc tgatcgtccc ggtcgggcat ccgctcgcgc ggcgcggcac ggccgtgctg
     1201 gaggacgcgg cgtccgaggc gtggatcagc gtcgagcccg acggctgcgc ccaccaccag
     1261 caggtcatga cctactgcgc cgccgccggg ttcacgcccc ggatcgccca caacgccacg
     1321 acctggtcgg tgatctgggc gctggtcgcc aacggcctcg gcgtgtcgct ggtgccgagg
     1381 ctggccgacg ggcagtccgg ccagaccgtc gtccgggtgc cgctgacggg cgactccgtc
     1441 ccgaagcggc gggtgctgac gtgcgtccgc cgggggagcc gcacccaccc gctgatcgcc
     1501 cgcggcctgg ccgcgctgca cgaggccgtc cccgcccaat gcgatctcct ccccgccgcg
     1561 acccgggccg ttcccgtcgc gagctgagcc tcagtcggtc gcgatcgcct ggaggatgtc
     1621 caggcgcgcg gcgcgggcgg cgggccagac ggcggcgacc acgccgatgg ccgcggcggc
     1681 cgcgacgcac agcgcgaggc gcccgtaggg gacggcgagc acctccatgc cgtcctcgcc
     1741 gcccgcgatc gccttctgca ggacgacgcc gagcacgctc ccggtcccga cgccgagcac
     1801 cgcgccgaac agcgacacca cgacggcctc gtagcggatc atgcggcgga gctggcggcg
     1861 ctgcgtgccg accgcgcgca gcagcccgat ctcccgcgtc cgctcggtga ccgcgagcgc
     1921 gagcgtgttg acgatgccga gcgcggcgac cagcaccgac agcaccagca gcccgaggac
     1981 cagcgtgagg aacaggtcga tctcgcccgc cgcgtcgtcc ttgacctgcg cgcggtcctt
     2041 cagctccagg ttcggccacg gcgcgagcgc cgactccagc gccgcccgcc gggcacccgc
     2101 gaccgtgacc tcgatgcgct cgatcggcgc gtccgggtcg tgggcgcggt acccggccca
     2161 gtcgatgatc accgtgggcg cggacggggt gagcgccggc cggtcggcgt agatcccggc
     2221 gatgcggaac gtccgcctcg tcccgtcctg gtactcgccg gggatcgtgc cgccgatcct
     2281 ccagccgcgg tcgcgggcga cgctgcggcc gaccagcagg tcctccccgc gtacggccgc
     2341 cgagccctgc tggagcggca gccggaagtg ggccagcagc tcgcccggcg aaccggcggt
     2401 cgcggcctgc acggcgccct ccagccggaa ccgggccgtc cggaccggga tcgccgcgcg
     2461 gacgcccggg acgcggccca ccgccgccgc cgcgcccgcc tcgaccggcg tgacctggct
     2521 gcgcccggtg acctggtagt cggcggtcag cgcggcctcc agctgccggt cgaccgaggc
     2581 cgccaacgac tggacgatga tcgacacggt cgcgatgagc gccagcccga tcgtcagcgc
     2641 cgacgcggtc gccgacgtct gccgggggtc gcggaccgcg ttgcgggcgc ccatccgtcc
     2701 ggcgccgccg ccgaaccgcg cgaacgggcg ggcgaggacg cgggcgaccg ggcggctcag
     2761 cgcgggcgag accaccacga cgcccgcgaa cagcagcgcc gcgccggtcc cggcgagcgt
     2821 gaggccggac gtcccgtccc ccgcgagccc ggccgcggcc aggatcccgc cgaccgccag
     2881 caccgcgcat ccgccgaggg cgcggcgccg cagcgggcgg ggcggcgccg cgtcctcccg
     2941 cagcgccgcg accggcggga tccgcgccgc gcgccgcgcc gggacgaacg ctgcggccag
     3001 cgccaccggc gtccccacca ggtaggcggc gaggacggcg gacgcgggca gcgcgagcgg
     3061 cccgaacggc agctcctccc cgccggtgac cagcgtcatc agcctggcga gcccgagcgc
     3121 gaccacggcc cccgccgcga ggccgagcgt cgagcccgcc aggccgaccc cggccgcctc
     3181 gccgaggatc gagcgcgtca cctgcccgcg cgaggccccg acggcgcgca gcagcgccag
     3241 ctcccggacc cgcccgccga ccagcatcgc gaaggtgttg aagatgatga acgacccgac
     3301 gaacaccgcg atcagcgcga agaccagcag gaacgtgcgc atgatcttga tgatgtcctt
     3361 gagtgggccg gcctgctcgg ccgccgcctc cgccccggtg acggcctcga cgcccggcgg
     3421 gaggacggcg gcgaccgcgt cccgcaggcg ctcctgggtg acgccgccgt ccgcgtgcac
     3481 gacgatgcgc tcgtaggtgc cgggacgctg cccgagcagg cgcggcgcgg cgtccggcgc
     3541 gaacgcggtc atcgagatcg aggagccgag cgcggagtcg ccgacccgga acaggccggt
     3601 cagccggaac gtccgcgtgc cggaccgcaa cgcgaccgtc acccggtcgc cgacccggta
     3661 gcgggcgtcg cgggcggtgg tggcgtccat ggcgacctcg tccggcgcgc gcggcggcgc
     3721 cccggcggtc aggcgggtca gcgacaggtc gcggtcgccg ctccacgcca ccccggtctg
     3781 cggctccgcc ccggcgatcc tcccctgccg gtcgacggcg gccgcgaacc cggtgatgac
     3841 gccctccgcc ttcgcgacac cgggcgcccg ccggacggcc gcgagcgccg acgcgggcac
     3901 cggacgcggc gccgcgcgct cgcccggccc cgtccggaac gactgccgcg ccctgacgac
     3961 cgtgtccgtc ccgcgcccga ggtcgtcgaa ggcgcggtcg aacgagcggc tcagcgtggc
     4021 cgagaagatc agcgtgccgg agacgaacgc gacgcccgcg acgaccgcca ccaccgacag
     4081 cagcaggcgg gcgcggtgcg cggccagccc acggaatacg agcttcacca tcatggccac
     4141 gattcgaccg gtgcggggcg gggccgcggc agggcgcatc gtcgcgtccg catccgggcg
     4201 gcgcacgacg aacggcaggc cggacccgac tttcgtaggg gtccccggcg gggcaggggt
     4261 gcgtacggtg ggcccgtgcg cctcacaccg ccgcccgcgc cccccggacg cgacctcgcc
     4321 gccgacgccg tggccgtggt gtgcgcgctg gcgctgagcc tccagacggc ggcgggcccc
     4381 gactcggtcc tgcgcggcca ccacggcgcg acggccgcgg tggtggcgct ccccgcgctc
     4441 gcgctggcgg tccgccgccg gttcccgatg acggtcgcgt ggctcaccgc ggcggtcgcc
     4501 gcgctgctgg acgccgtcga gcgcctcgcg cccggcacgc tgctgcgcga cggcccgccc
     4561 ggcgcgttcg acccgatcgt gtggtggccg cccgcgctgc cgttcgccgt ctacgccgcg
     4621 atggccttcc cccgcgacgg ggaccggccc gtctgggcgc gggcgctgcc ggtcctcgcg
     4681 ctcgtcccgc tggtcggcct cacccaggac gtgatccccg acgagtcgat caggcgcgtc
     4741 tcggggcagg agacgtcctc ggtcgagacg atggtcttcc ggagcatggc gatgctggtc
     4801 gcggcggcgc tgctcggcat gtacgtggcg gcgcggcgcc gcgtcctgca agggctgacc
     4861 gagcgggccg agcgcgccga gcgggagcgg cacctgctcg ccgagcgggc gcgggccgag
     4921 gagcgcgccc ggctcgccgc cgagatgcac gacgtcgtcg cgcaccgggt gacgctgatg
     4981 gtgctgcgcg cgggcgcgct gcgggtcagg gcgcccgacg aggagacccg cgccgccgcc
     5041 gaggagctgc gcgacgacgg ctgccacgcg ctggaggagc tgcgcgacgt catcggcctg
     5101 ctgcggcgcg gcgccggggc ggcgggcgcg gcccccgccc ccgcgtcggg gccgctaccc
     5161 gacctgtcgg agctggtcgc cgagtccgcc gccgtcggcg tccgggtcga gctggtggag
     5221 cgcggggagc ccgcgcccgc ctcgcccgcc gtcgggcgca ccgcctaccg ggtcgtccag
     5281 gaggcgctga ccaacgcgcg caagcacgcg ccgggcgccg ccgtccgggt ggaggtcggc
     5341 taccgctccg acggcgtccg gctgagcgtg ctctgcgccg ccccggaacg ggacccggac
     5401 gcggcgctcg cggccagcgg ctccgggacg ggcctcgccg ggctccgcga gcgcgtcgag
     5461 accgtcggcg gcaccttcag cgcgggcccg gccggggacg ggttccgcgt cgaggcgtcg
     5521 ctgcccgcct acgtccccct cccgacgccg cccgcgccct gacggtgcgc gtggtggcgg
     5581 aggtgccggt gccccaacgc catcaggagg gcccgcaccg cccagaccgc cagcgccacc
     5641 tggaggacga ccaggaaccc cgggcccggc cccatcgtga acgccagcac caggaacagc
     5701 ccgagcagca gcgggaacgg cggcccgtga cggtggcggc catggtggtg gcggccgagg
     5761 tggtggtggc cgaggtggtg cggccggccc cggtggtgac gcgcgggcgc cgcctccggc
     5821 accgccaggc cctgcgggtc gggcaggtcg aggacgaccg cccgcaggtc gccccgcgtc
     5881 cgggccgcca gcgtcgtgcc gagccgctcg tcgagttcct cgcggtcgag ccgtccggcc
     5941 gcgaagtggt cgtgcagggc gaccatgacc gcgtcgcgct cggcgtcgcc gacgcggacg
     6001 tcgccggagc ggatcccctc gggggtcgtc acgccggctc ctcacccggg ccttgggcgg
     6061 tggggccttc ggcggtgggg cccgcgtcgg ccccgcccgc gcgcggctcc tcgccggcga
     6121 ggacgcggta cagggcgcgc cgggtctcgg agaggatctc ggtggcccgc ctgacctggt
     6181 ccggcgtccc ggagtggacg atctgcatca ccgccgcgcc cgtctgcgcg acctgccgga
     6241 acagctccgg cgcgccctcg ccgaagtcgg gcgccatctg cgcccacggc tcctccagct
     6301 cgtcggcgtg ctcggcgacg taggcgccgc cctcggccgt gagccggtag gtgcggcggc
     6361 cgccgccctc ctcggcggtg atcagcccct cgtccgcgag ctgctggagc gccgggtaga
     6421 ccgcgccggg gctcggcttc cacgcctcgc cgctgcgctc gttgatctcc tggatgatct
     6481 ggtagccgtt gcgcggctcc tcggcgagca gggcgaggat cgccgcgcgg acgttgccct
     6541 tgggcgcctt gcgcccccgt ccccacgggc cgcgcccgcc gccgcgcgcc cagggcgggc
     6601 gtcccccgcc gggtccgaag ccgccgggcg ggccccactg ccagggcccg ccgtgcgcgt
     6661 gctcatggcc gtgcccgtgc ccgtggcccg gcccgaagcc gtgctcatgc ccgtgcccgt
     6721 gccgggacgc cgcgtgcgcg gccttcgcgc cgatcgccgc cgccgcgaac gcccagcgcc
     6781 agtcgggccc gctccgatgc gtcgctccca tggtcaccac caccttctga gatctctcta
     6841 tgatctctcg cgataggaca acgatatatc gaagacgtac ggttcgggaa gatggttccc
     6901 gcgaaaaccg cgcctccggc gcgtcgcgcg ggtccgccgg atccgggcat ggtcgtctga
     6961 ccggcggaaa tcctgggtaa ccacccctgt ggggggacga tggggacgga cgaggcgatg
     7021 accgcgccgg acgcggtcgt gaccgggggc ggcgcggtcg cgcgcgggcg cctgcggggc
     7081 gagctgctgc tgggcatggc ggtcttcggc ctgtacgcgc tggtcgtgat gctgccgcag
     7141 gacgccaggg agcgggccgc gcgcgggcac ggccgcgcgc tctacgacct ggagcgggcg
     7201 ctgcggctgg acgtcgagcg gacgctgaac ggctggctcg ccgggcagcc ggtctggcgc
     7261 gtgctggcca actacgagta cgcgatcacc tacatcgcga gcgcggtcgc gctgctcgcc
     7321 tggctgtacc tgcggcaccc ggagcgctac cggacggcgc gcaacgcgtt cctgctgatc
     7381 aacctggtcg ggatcgcctg cttcgcgctg tacccggtga tgccgccgcg gctgatgccc
     7441 gagctcgggt tcgtcgacac ggtccggctg ggccgcacgt gggggtcgtg gggctcgccg
     7501 atggtcgagc acgccgaccg gttcgcggcc gtcccgtccc tgcacatggc ctggacgctg
     7561 tgggtcggcg tcgagctggc ccgggtgtcg gcgcggcggt gggtgcagtc ggtgaacgcg
     7621 gtccacatcc tgctgaccct gtatgtgatc atggcgaccg ccaaccacta cctgctggac
     7681 gcgctggcgg ccgtcccgct ggtgggcttc gcggtgtacg ccgccgagcg cgcgaccccg
     7741 cgcggcgcgg gcgagcgggt ccgcgggccc gacgcgttct tcctggccgt ggagaccccg
     7801 gaggcgcccc agcacgccgg ggggctgatc gtcctggaca ccgcgcgggc gccggtgacc
     7861 cgcgacgacc tggccgccct ggtcgccgcg cggctggagg accacccgcg gttccggcag
     7921 cggctcgccg acggcggccg gtggcggcgg ccgctctggc gcgacgaccc ggcgatcgac
     7981 tgggcgtggc acgtccagga gcgccgcgtg gacggcatgg ccggactgcg cgccgtggtc
     8041 gccgcgatcc agtccgagcc gctgccccgc gaccggccgc tgtggcggat gatcctggtg
     8101 accggggtcg cgccgggacg cgacgcggtc gtgttcctca tgcaccacgt cgtcgccgac
     8161 ggcgtcgggg tcgtcgcgca cgcgatggcg ctcatggagc cctacccgct cgactacggc
     8221 gggacggggc gccgccgcag gcccgtccag gaggcgctcg cgacggcgac cgggctcggc
     8281 cagctcgccg cggacgcggc gcgccccgcg cggctgcccg ccgccgggac gtccgagcgc
     8341 cggttcggca ccctgctcgt cccactcgac caggccaggg acgtcgcgcg gcggcacggc
     8401 gcgcgggtca ccgacgtcgt gctgtgcgcg gtggcgggcg ggctgcaccg ggtgctccgc
     8461 gagacgccgg gcgccggcga ctcctgccgg gtcgcggtgc cgctgatgat gcgctcaccg
     8521 ggcgacggcg cggagggcaa ccacaccagc gccgtcatga tcgacctgcc gatcggcaag
     8581 atgcccgagg ccgaccggct cgccgagacc gcccggcgcg cccgcgtgct gcggtcgggg
     8641 acgcgcccgc tcgccgcctg gttcgtgatg cgccaggccg ggcgggtcat gcccgccccg
     8701 ctgcacgccc gcttcgcccg ctacgcctac agcgcccggt tcctccaggg catcgtgtcg
     8761 agcctgccgg gccccgaccg gctgctgcgg ctggcgggcg ccccgctgct ggaggtctac
     8821 ccggtgatcc cgctggcgcc cggcgcgccg ctcgcggccg gggcgctcgg cgtcgaccgc
     8881 gacctgtgct tcggcgtctg cgccgacccc ggcctcgtgg acgacgccga ccggatgacg
     8941 gccgccgtcg cggaggtcgt ccgcgaactc cgcgaggccg actagccccg gagggtcagc
     9001 cgctgcggat cgcgcgcagc gactcggtca gcgacccgat cgtggcgaag acggcggtcg
     9061 gctcgtagcc gcagtgcgcc atgcagttgg agcagcggtc gtcgcggccc cggccgtagg
     9121 cgccccagtt ggtcgtccgc acgagctcct cgtaggtgtc ggcgtagccg tcgtccatca
     9181 ggtagcaggg gcgctgccag cccttcagcg agtaggacgg gatcgcccac gccgtgcacg
     9241 ggaagtcggc cctgccctcc aggaagtcca ggaacagcgg cgagtggttg aaccgccagc
     9301 ggcggcgccg gccgtcggcg aacaccttcc ggaacagctc ccgcgtctcc tgcacgccga
     9361 ggaagtgctc ctggtcgggc gccttctcgt aggcgtaggc gggggagatc atcatctggt
     9421 cgacgcccag gtcgtcgttg aggtagtcga ggacgtcgat gacggtctgc ggggtgtcgg
     9481 tgttgaacac ggtcgtgttc gtcgtgaccc ggaaaccgcg ctcgcggcac atcgcgatgg
     9541 cctccacgac ctggtcgaac acgccgtcct tgcagacgga cgcgtcgtgc cgctcgcgca
     9601 gcccgtccac gtgcaccgcc cacgcgaagt accgggacgg ctcgaacagg tcgatcttct
     9661 tcgggatcag ggcggcgttc gtgcacagga acacgtaccg cttcatcttg accagctcgg
     9721 cgaccatctc gccgatcccc gggtgcatca gcggctcgcc gcccgcgatc gacaccatcg
     9781 gcgcgccgct ctcgcggacc gccgcgaccg cctgctcgac cggcatccgc tgcttcagca
     9841 ggctcgccgg atgctggatc ttcccgcacc ccgcgcaggc gaggttgcac gcgtacagcg
     9901 gctccagctc gaccagcagc gggaacttcg cgcggcgggc gagcctgttg cgcaggatgt
     9961 agccgccgac ccgcaggctc tggcgtagtg gcatgcccat ttacgacgcg tcctccctca
    10021 ggtagcggcc gagggcgctc accgggaaca ccagccggta caggtggtag ttgatgtaga
    10081 agtagccggg gaacccggtt ccggtgaagt ggtcctcgtc ccaggtcccg tcggggcgct
    10141 gccgctctgt gagccagccg acgccgcgct cgaccgccgg tccgcgctcg ccggcggcca
    10201 gcagcgccag cagcgcccac gcggtctggg acggggtgga cgcgccgcgt ccgatccacg
    10261 ccgggtcgcg gtaggagcgc aggtcctcgc cccagccgcc gtcgtcgcgc tggtgccgct
    10321 ccagccaggc caccgcccgc cggatcaccg gcttgccggg ccggacgccc gccgcgatca
    10381 gcgcgggcac gacggcgccg gtcccgtaga cgtggttggc gccccaccgc ccgtaccagg
    10441 agccgtcctg ctcctgcgcc ttcagcagcc acaccacggc gcgcttgcac agctgcgagt
    10501 cgcccatccc ctgcgcgcac agcgcctcca cgacgtgcgc ggtgacgtcg gcggacggcg
    10561 ggtcgatgac ctcgccgaag tcgcagaacg ggagcctgcg gcacagctcg cgggtgttgt
    10621 cggcgtcgaa cgcgccgaac ccgtcgtcgc gcgagaccat cccggccatc cagcgcaggc
    10681 cccgctcgac ggcgggcggc gcgtccggat gcgcgacgcg gccgagcgcc agcacgacct
    10741 cggcggtgtc gtcgacgtcg gggtagtagt cgttgtcgaa ctcgaacgac cagccgccgg
    10801 gcggcaggcc ggggcggcgc acctgccagt cgccggggcc cttcacctcc tcgccgacca
    10861 cccacgcggc ggccttctcc agcgccgggt gcccggcggg catgcccgcg tcggcgagcg
    10921 cggtcatggc gagcgcggtg tcccagaccg gggactggca cgcctccagg cgccgcccct
    10981 gcccgtcccg gatcgtgaag cgctccaggc cctggagccc gcgccgcatg accgggtggt
    11041 cgacgtcgtg gccgagcagg ttcagcgcga tgagcgagta cacccacggc ggctggatgc
    11101 cgccccacga cccgtccggc tcctgccgcg cgatgatcca ctcggcggcg cggcgcagcg
    11161 cggcccgccg caccgccttc accgggcgcc gctggtagac gcgcagcgcg cggtcgagcg
    11221 cgtggaacgc ctcggcccag ccgggcggcc cctggcgcct cctccgcacg tgctggccgt
    11281 gcagctcggc gatgtcgaag ggcagcggcc ggacggggcg cagcgccgcc gccaccgtca
    11341 gcggcacgat cgtctgccgc gcccagcacc cgaagtcgta gacgttcagc gggaaccacg
    11401 acggcaggta gatcatctcc ggcgggacga cgggcagcgc gtcccacggc cagcgcccga
    11461 acagcgccag ccagtagcgc gtgaacacgc gcgtcgccgg gaggccgccc gcctcgcgca
    11521 cgtacgcggc ggcgcggcgc atgtggtcgg cgccggtcgg gtccccggcg agccgcagcg
    11581 cgacgtaggc ctcgaccgtc gtggacaggt cgggcgggcc gccgaagaag ttcgcccacg
    11641 tcccgtcctc gcgctgctgg gagcggatcc agcgggccgc ctcccgcgtc tcctcctcgt
    11701 cgcggacgcc gaggaactcg cggagcagca ggtcctcggc gtccatggtc acgttcgtct
    11761 ggagctcgcc cttccaccag ccctcggggg actggaggcc gagcaggtgc tcccgcgccg
    11821 cgtcgagcgt cttgcgcgcc gcctccctgg tggagggggc ggcgggttcg gctgtcgtgg
    11881 tcatcagtgg tcccggtggg tgacgaagtc ggcgacgcgc aggaactcgg tgcggacggg
    11941 ggtgggcacg cccgctccgg cgaggtgctc cccggcgctc tccacccggc gcgcggcctc
    12001 ggcccgcgcc cacgccctgc cgcccgcgag gtcgacgagc cgcgccgcct cggccagctc
    12061 gtcctcgccc ggcggctccg gccgggcgta cagctcggcc agcgccgcgg acgcgggcgt
    12121 gccggagttc agcgccgcca cgaccggcag cgacatcttg cgggaccgca ggtccgacag
    12181 cgcgggcttg ccggtcgccg ccggatcgcc ccagatgccg agcaggtcgt cggtgagctg
    12241 gaacgcgacg ccgaggtcgg cgccgaaccc ctccagcgcg gccgcgaggc cctcgggcgc
    12301 cccgtccagc acggcgccga tcgagcacga gcaggccagc agcgcggcgg tcttcccggc
    12361 ggccatcgac tggcactcct ccagcgtgat cttgtggcgg gtctcgaagc tcaggtcgag
    12421 cgactggccc gcgatgaggt gccgggtcgc gacggccagc gcgcgcgccg cccgcgccga
    12481 gccctggccc ggcgcctcca gcagcacctc cccggcgagg gcgagcagcg cgtccccggc
    12541 caggatcgcg gcgggctcgc cgtagacggc ccacgccgcc gggcggtgcc gccgcgtccg
    12601 gtcgccgtcc atgatgtcgt cgtgcaggag cgagaacgcg tgcgtcagct cgaccgcgac
    12661 cgcgcccggc agcgcgctct ccggcggcgc gcccgccgcg cgggccgaca gcagggccag
    12721 cgcggggcgc agcgccttcc cggcgggctc cttgcgcggc cgcccctccg cgtcggccca
    12781 gccgaggtgg taggccgcca cccggtaggt gtgcgggtcg agccgcccga ccgcggcgcg
    12841 cagcgccccg tcgaccagct cgcggacatc ggtcatcgag accggaacgg tcgtcaccgg
    12901 cccctcaccc cctcaaggtg gcggcggacc aggcgtgcgg cggtcagacc gctgcgcact
    12961 gctccctcca tcgtgtcggg ccagcccgtg tcggtccacg cgccggcgag gaacaggccc
    13021 ggcgcccgcg tcgccgcgcc gggacgcgcc gcgccgctgc cgggacgctg gcggaacgtc
    13081 gcccgccgct cccgcgtgac gaagaagtcg gtgacggacg cgtgccgggc ggcgggcagc
    13141 agccggcgca gctcgcgtgt gaaccgctcg cgcagccggg ccgtcgggac gtcgatccag
    13201 cggtcggccg ccgacagcga gacggccagg tactgcccgt cgccgcgcag cccgccgacc
    13261 accgtccggt cgaacgccca ctggacgggc gagccgaccg ccgccacgaa cggcagcccc
    13321 agcaccggcc ggtcgtagac gacgtgcacg ttgacgatcg ggctcgcgcc cagctccggc
    13381 cagcgcagcg ggtcgggcag cgcctcggcg ggcagcagcc gcgccgccgc ctcgtgcggc
    13441 acggccatga ccaccgcgtc ggccgcgatc ggcgccccgt ccacgatcac cttcgggtcg
    13501 gcggtgaccg cctccacctt cgccttgagc aggacggtgc cgcccgcctc ctcgatccgc
    13561 gccagcgcgg gcccgccgtg caggtccgcc agcgggacgg acgggacgcc gatgtcggcc
    13621 gcgtccgcgc gcccgaacag cgcccgccgg cacaccatcg ccgacaggcc gagcgccgcg
    13681 tcgtccacct cggcgttcag cgcggccgtg acgaacagcc cccacagcgc ctcgcgcgcc
    13741 caggggcgct ggccccgctc cgccagccag gtgcccgccg ccaccccgtc caggacgggg
    13801 tcggccgggt cgagggaccg gatcctcgcc gccgcccaca ccgccctcag ccgctcggcc
    13861 gccgacagcg gcgcgtagcg ggccagggcg ggcagcaggt gcagcgggct cggcagcggc
    13921 gcccgccgca gccgcgcggg cgccccgccg ggccgcagca ccgtcacgtc gaacctgcgc
    13981 tgcacgtcca gcaggtggtc ggtgcccagg cgctggagca gcccctggta ggcggtgcag
    14041 cagcgcagcg cgacgtgctg gccgttgtcg acggtcaggt cgccgcgccc gaacgagtgg
    14101 gtggcgccgc ccagccaggg gcgcgcctcc accagcgtga cgtcggcccc cgcctcctgg
    14161 agcgccaacg ccgcgctgat gcccgcgagg cccccgccga cgacgacgac gctcaccgcc
    14221 cgccccccgt caccgctcga cgcccgtcag ggcgcgggcc gccacgacgg ccttctgcca
    14281 ggtcggcagc gacacccgcg aggtcagcgc gagcgccggg ctctccgcga tgcgctccag
    14341 cagccgccgg tagatccccg ccatcgccgc cgtgcacgcc gccgagcgcc ggtcgagcag
    14401 cggcagcagc cgcagcccct cggcgtacca ggcccgcgcc cgctccgcct ggaacgcgac
    14461 gaggtcgtgc agccgcgacg ccgggtcgac gaactcgccc gtctcgtcca gctccagcgt
    14521 gcacccgaac cggtcgaggt cctcggcggg caggtacacc cggcccgcga gccggtcctc
    14581 cctgacgtcc cgcaggatgt tcgtgagctg gaacgcgacc ccgagcgagt ccgcgagccc
    14641 ctccgcgcgc tgccgcccgt cgtagccgaa cacgcccagc gacaggcggc ccaccgtgcc
    14701 cgcgacctgc tggcagtacc gcagcaggtc gtcgaacgtc tcgtaggcgg cgccgcgcac
    14761 gtcgctctcg cagccgtcga tcagctccgc gaacgcgtcc agcgggatcg ggtagcggcc
    14821 cgccgcgtcc gccagcgccg tcagcaccgg gtgcccctcc agcgcccgcg agtcggcccg
    14881 ccgccacagc acctcctgga ccgtttcgag ccgcccgcgc gcccggtcca gcaggtccat
    14941 ccggacgcac gcgggctccg ggccgtcccc gatgtcgtcc acgccccgcg cgaacgcgta
    15001 gatcgcgctc atcgcgcggc gcttcggggc gggcatcagc cggatcccgt agccgaagtt
    15061 gcgggcctcc tcccggacca cccgctcgca gtgccgatac gcctccacga cccactcggg
    15121 ccgctcgcac gtctccgaaa ccgtcatcgc tcaccctctc cgagagcgcg ggttctgcct
    15181 cgtccgtcct ggagcggatg cgtcatcgcc ggccccctcc gagagcggag gcccagttgg
    15241 cgaggagcac cggcccgcgc ggacgcggcg tccgcgccag cacgtcgtag cggccgcgca
    15301 cgagcgcggc cagcgccgcg cgccccccgg cgacatagcc cgccaccgcg atccgggccc
    15361 acccgcgcag gcccgccatg agcggcgcgg cgccccggtc gagcaggtcc cgcgcccggt
    15421 tcgactccag cgccagcacc ccgcgcagcc gcgtcggcgt caccgcccgg gacaggtcgt
    15481 cctcggcgca gccgaaccgc cgcaggtcct cgccgggcag gtagatccgc ccggccctga
    15541 agtcctcggc cacgtcctgg cagtgctcga tcacctgcag cgcggtgcag acccggtcgg
    15601 acgcctcctc cagcccccgc ccctccgcgc cgaacacgtg cagcacgatc cgcccgaccg
    15661 gattggccga caggacgcag taccccagca gttcgtcgaa ggaggcgtag cgggtcacct
    15721 cctggtcccg gcggttcgcc tggaccagcc gccggaaagg ctcctgcgga attcccctcg
    15781 cgtggacggt ctccgccagc cgccttaact gcggaagaac cggcgcccgc cctttgtaga
    15841 ggaggtccag gtccgcgtcc accgaatcga gcagcgccac ccggtgcgcg cccggcgcct
    15901 cgtcgccgat gtcgtcgacg aggcgcgcga aaccgtagac cgcgcgcagg tgggcgcggt
    15961 gccgccccgg cagcagccgg gccgcgaccg ggaagttctc ccgccgcgcg agcgcgtcca
    16021 ggccccgctc gtgctcccgc gcgctccagg gtggttcagt ggtcaccact aggagattcg
    16081 ccggtgcggc accagaaaaa ctctgatcaa ggtatggagt tattgaaccg gcgcgcgttt
    16141 ccgcgaccga aaggacgcga caggaaagtc gccttttgtg gtaattagct cgctatcggg
    16201 cgcggccggt cacggcagcc ggccgaccag gctgagcgcg acgtccagcg cgcggctgcc
    16261 gggcgtcccg tcgccctgcg ccgtccacac ctccgacagg acggccatca cgaaccccca
    16321 cgcgacgacc cgctccaccg gcatcgcgag cccgtcggcc acctgctcga tccgcgcggg
    16381 caccaggtcg accagcctgc cgtcccggtc gtcggggccc gggttgtaga acaggacgcc
    16441 cgcctcgtac ccggggtcgc ccaccacgcc gtgcgggtcg atcgccagcc acggctcgcg
    16501 ctccgcgctc aggatgttgt cgtggtgcag gtccccgtgc aggacgagcc gctcgggcgc
    16561 gctcgcgcac aactcgtcga acagccgtcc ggcgcgctcg acgaggtggc gggggagcgg
    16621 gccgtcgccc gggaagcggc gcaggtggcc ggagaacgac gcgctctcct tctccaggcc
    16681 cgggagggcg catccgggag gcggcacgtg ccggagccgc cgcgccacgt cgaggaacac
    16741 ggcggtggcc tcctcgtcct tgtccgggac gagttcgctc agcaccctcc ccggctcggc
    16801 acgctccaac agcagcgcgc cccggcccgg gtcgtgctcc agcagccgca ccgcgccctc
    16861 gccgccgtag atctccaggg ccgccgcctc gatgccgagg tgtccgggtt cgggcgggcc
    16921 gagcttcagg accgccttcg tcccgtcctc cctccggacg ggcgcgaccc agtggtagct
    16981 gaggccgtac cgggcggcct cgatctccag ccgccactcg cgggcgatct cggcgagcag
    17041 gccgggcagc cgcttcagcc agcggcggcc gtcgtccccc cagacctcga cggcgttctc
    17101 gacaaggacg gacgggagcg gaccaggaag aatcggcggc atccgcccaa ccctgccaca
    17161 gggcgtgaac gcgtaggaac gccgaatcgt cctaggaatg tgacgacccc actggttccc
    17221 ggcgatcccc gcgagctcgg cgactactgg ctggcccgcc gcctcggcgc gggcgggcag
    17281 ggggtggtct acgaggcgta cggcgcggac ggcgcgcgcg tcgcggtcaa ggcgctgcac
    17341 ggggtgttcg cgggggagcg cgccggcggg ccccgggacg tgctcgcccg cgagatcgac
    17401 gccgtgaccc gggtgtcgcc gttctgcacc gcccgcgtgc tggcgttcga cctggacgcc
    17461 gagcccccgt acgtggtcag cgagtacgtc cccgggcccg acctggagcg cgccgtcgcc
    17521 tccggcggcc cgttcgggtc cggcgagctg ggacggctcg cgatcggcgt cgcgaccgcg
    17581 ctcgtcgcga tccaccgggg cggggtcgtc caccgcgacc tcaagcccgg gaacgtcctg
    17641 ctcggccccg acgggccccg cgtcatcgac ttcgggctcg cccgcgccga ggacatgacc
    17701 cgcagcgcga ccggcgccaa gggcacgccc cgctacatgt ccccggaggt cttcgcgggc
    17761 gagcccgcga gcgccgcgtc ggatgtgtgg gcgtgggggg cggtggtgct gttcggcgcg
    17821 ctcgggcggc cgccgttcgc gggcgagaac ctgatgcagc tctcccacac cgtccagcac
    17881 gtggagccgg agctgcacgt gctggacgag ccgctccggt cggtggtggc tgcggcgctg
    17941 gcgaagcggc cgcgggaccg cccgtcggcg cgcgaggtgc tgctggacct cctcggcggc
    18001 tccttcgacg agggggcgat gctctcggag gggagccggg tcgccgccgc ggccgcggcg
    18061 ggtgccgcgc cgccctcgct cgcggacgtc gccgaggccg cctaccggcg gctcgacccg
    18121 ctcgcgcggg aggccgtccc cgcgatcctg ctgcgcatgg tgctgccggg cgagggcgcc
    18181 gccgacaccc tccgccgggc cgcggtcgac gagttcggcg acggtgccga gcgggcggtc
    18241 gaggagttca cgcgcgccgg gctgctggtc cgcgagggcg accgggtggc gatctgcggc
    18301 gcggcgctgc tccgcgcctg gccgcggctg cgcgggtggg tcgatgacga gcgcgccggg
    18361 ctggccgtgc accgctcgct cgcggacgcc gcgcgggtct gggaccggca cggccgccgg
    18421 gccggtgacc tgctccaggg gagcgtgctg gcccgcgccg tccagtgggc cgcgaccgga
    18481 cgccgccacc tgacgctgaa cgccgtcgag cgcgcgttcc tggacgcctc ggcggccctc
    18541 ggccgccgcc gcgcccgcag ccggggcgcg ctgacggccg ccctcgccgt cctgctggtc
    18601 gtggccgtgg gcggggccgt cgtcgcggtg aaccagcgcg cggtcctctc ccgccagcgc
    18661 gaccgggcca tcgccgaccg gctcgccgcg ctcgccgcgt ccctccaacg cgacgacccg
    18721 cgcaccagcc gccgcctcgc cctcgccgcc gcgcgcgtcg gcgacgacga ccagacccgg
    18781 aaagccctca tcaacgccat gtaccagtgg gagggcgata cgttcaaccc cgcctccaat
    18841 gcccaggtgg tcctcacccc cgacggccgc accgccacgt tcgacgatcg cgtccaggtg
    18901 acacgctggg atctgaagac gcaccagcgc gttccgatgc cgccgggggc cgagccgaaa
    18961 agcgcggccg tgttcagtcc ggacggacgc catatggcgc agctcttatc caccggggga
    19021 gatctgagcc ggcgcggtgt ggtccaggtc tacgacgcgg ccaccggaaa gccgcagggc
    19081 aggccgatgg gcgatccgcg tcaatccttc tggaacctgc ggtacagcgt gagcggcaac
    19141 cttttgatga tggacaacgg gcctggaggc tccggcgatc cccgaacaac cgctcccgaa
    19201 atggctttat gggacgcgcg cagcggtcgc ctcgccatga gctggaagga gcgcccctac
    19261 gcctgggccg tgagcgccga cgacgccctt gtcgcgatgg tcctgccgag cggcttccaa
    19321 ctgtgggacg tcgcggcccg caaacggatt cccacgccgt ggctgggtgc ggcgctggct
    19381 tccgagagcg cgtcccagcg gatacgccag gtcgggttcg ggcccgccgg agccaggctc
    19441 gccctggtcg ccggcagcgg ggtgaccgtg cttgatctga acaacctggc gcgcaccgag
    19501 cccgtcgcct cgcggtctcg ggtcccctgg cacgagcgga gtgcgcgcgg cgtggacgaa
    19561 ccggtgttca gccccgacgg ccgcctcctg gccgtcgggt tcactctatg gaatctggac
    19621 ggctccgccg aggcgcccct gatggcccgc gggctcgacg acgagacgcc gaccgactgc
    19681 cgcttctccg ccgccggtga cctgctgcgc tgtgcgacga ccctcgaccg cgtcgtcacc
    19741 acgaacatct cgggctacgc cgaccggatc tccgtcggac gcgacgccgg acacggggtg
    19801 ctcagcccgt ccggcgacct cctcgcctcc atgggcgcgg acagcgtctc catcaccggt
    19861 aatccggcgg ggtggacgtc ccctttctcc gtgccttcct tgagaagcgt ttggcgaggg
    19921 atggtcttca gccccgacgg cggtctggtg gccattcccg accggaaccc ggacgacggc
    19981 ttcggcgtgt gggacgcgcg cacgctccag aaggtcgcgg agctcgactg gcccgacggc
    20041 gcgctcggca aaggcgtcgc gttctccccg gacggccggt ccctcgtcgg cggcctgaac
    20101 gcggaggtca tcgacccgcg gcacccctac aagtcgtggt tgcaggagtg ggacgcccgc
    20161 tcgggccggc gcacccgcgt catcccgttg gagtcctccg gatcggggga gctgttctac
    20221 cgatccgacg gtcgtacggt gaccttgaag agcgccgtcg tcgacatgga ttcaggacag
    20281 gtccacaagc ggttcgactt cttcagcgtc gtcgacgtgc tggccgtgtc tcccgacggt
    20341 tccgtcgccc tggtcatcat caaccccgac aacttgtacc tgtgggacct ccgaggcgac
    20401 aagcgaagag gaacgcccct ggccgccgtg cccgacgtgg aagacctgcc cgccgcgttc
    20461 tcccccgacg gccgcctggt cgccaccagc gacgcgcgcg gcggcgtcca cctgtacgag
    20521 gtggccactg gacggcccta cggccccacc ctccccggcc acgccggtgg tgtcgacacc
    20581 ttcgcgttct cccgagacgg caccgtgctc tacacctacg gaggcgaccg cacgattcag
    20641 gccaccaccc ttgatcccgc ccgcctcacc gaccggctat gcgcccaggt cggcggcctg
    20701 agcgaagccg agtggaacca gtacgtcccc gacctctcct atagacccgt ttgtggctaa
    20761 agatctttac atgtaggcca tcatgtcggg ccgggatggc tccagccatt tcggcgaaat
    20821 gcgccacagc ggcctcggct gagccttgca ggtcagcgcc ctggcgtccc aatcgatctt
    20881 gcggagaaaa ctttgaaagt atggccggga atggtgtttt cgggtcgtcc ggcttgtccc
    20941 cgcatgggga gatcggtgat cttggagcga ccgggacggg tcggtcaatt cgccacaaac
    21001 ggaccgttcg gcgcaccgat cgaccgttcg gccgacaggc cctgaccgcc ctcctgacaa
    21061 gccgtcgtga tcatgcgatg ctccgcccga cgacgtcgaa cagtcgacgg gcggcccggc
    21121 cgccccggcc aggaaggggt cacggcgatg cgcgcgagac gacggacgac ctgggcgaac
    21181 agaagaagtc gcagctggcg gctgtccctt gtggcggcgg ccgtggtgct gctggccggc
    21241 gtcgccgcgc ccggtgcgcc ggccgacgcg gccccgaagg cggaggtgtg cgaattcagc
    21301 gtccagaagg acgtccctgc cactatgcgg gacgggacgg tgttgcgcag caacgtgttc
    21361 acgccgaaag gggacggcaa gttccccgtc atcctgatgc ggctgcccta caacaaggag
    21421 ggcgccctga gcttcgtcta cggcgccccg gaccgttacg ccaaggcctg ctacctcgtc
    21481 gtggtgcagg acgtccgcgg cgagtacaag tcggatggcg ccttctaccc gtaccggacc
    21541 gaggctgagg acggctacga caccatcgag tggtccgccg ctctgccgca ctccaacggc
    21601 aaggtcggca tgtacgggtt ctcctatccg gggctcacgc agtggctgcc cgccactctc
    21661 acgcctccgc acctggtcac gatcgccccg gcgttcacgt cctccgacat ctacgacgga
    21721 tggacctacg agggcggcgc gctgtaccag gcgttcatcc aggactggct gctgagcttc
    21781 ctcaacgggg gcgtcatcag caagctcccg gacgccgcga agctgcgggc ggagatgacc
    21841 caggcgtcgc gggacctgca caccaagtgg taccggcacc agccgctgaa caacttcccg
    21901 ccgctgtacc cgggggacaa ccgcatcgcg ccgtactact tcgactggat cgaccacccg
    21961 agcgacgacg actactggaa gcgctggagc atccgcacga agtatccgcg ggtcaacgtg
    22021 ccgtcgctga acttcggcgg ctggtccgac atcttcctca acgggacggt ggagaacttc
    22081 gccgggatgc gcgcccaggg cgggtccgag gtcgcccggc aggggtcgca gctcctcgtc
    22141 gggccgtgga cgcacggcgg ctcgggccgc acggtgggcg ccgtcgactt cggtccggag
    22201 gcggtcgtcg cggtgggcga tctgcacctc cgctggttcg accactggct gaaggggatc
    22261 gccaacggcg tggacgcgga tccgccggtg aaggtcttcg tgatgggcgc caacaagtgg
    22321 cgcacggctg actcctggcc gatccccggc accgccaaca ccacgtacta cctgcacagc
    22381 aagggcgacg cgaacaccgc gaacggcggc ggcacgctcg acaacaccgc gcccgcgacg
    22441 ggcgagaagg ccgaccagta ccagtacgac ccggcgaacc cggtgccgag cgtcggcggc
    22501 cgtttccaga gctcggtgcc cggcggcccg caggaccagc ggtccgtcga gcagcggcgg
    22561 gacgtgctgg tctacagcac cccgcggctc accaaggaca ccgaggtcac cggcccgatc
    22621 tcggtcacgc tgtacgccag gtcctcggcg aaggacaccg actggacggc gaagctcacc
    22681 gacgtccagc cggacggcac ctcgatgctg gtccgggacg gcatccagcg cgcccggtac
    22741 cgggtctcgc tggagaagcc ggagctgatc acccccgggg aggtctacaa gtacacgatc
    22801 aagctgtggc cgaccagcaa cgtgttcaag gcgggccacc gcatccggtt ggagatctcc
    22861 agcagcaact tcccgatgta cgaccggaac ccgaacacgg gcgggaagtt cggcgccgac
    22921 acgaccacgc agcccgcgtc gcagaccgtc ctgcacgacc cggagcaccc gtcgtcgatc
    22981 acgctgccga tcattccggt gcccgtccgc tgatccggcg caacggctgg cccgcgcccc
    23041 cgccgcgggt cagccggagg ccgggtaggg gccggccgcc gcggtcgaac cgcggccggt
    23101 acctccgctc ggcgagccgc agccgcccag cgggggcggc gtcagatgcg gccggtctcg
    23161 tgggcccaca tggcgacctc gacgcggttc cgggcgccga gctttcgcat gaggctggcg
    23221 acgtgggcct tgacggtgct cggggtgata tgcagctcgc cggcgatctc attgttggtg
    23281 cggccttggg ctacaggcac gaggacttcc tcctcgcggg cggtgagcgg ttctatcggc
    23341 tgcctccgtg gtggggtctg tgcgtgggcg aaggccgcga gcagccggac ggtcacgctg
    23401 ggcgcgatca gggcgtcccc gtcggcggcg gcgtggatgg cctgggtcag cagggcgggt
    23461 ccggcgtcct tgagcaggaa cccgcgggcg ccggccttga gcgccccgta gacgtactcg
    23521 tcgaggtcga aggtggtgat gaccacgatc ggcagtggat cggtgacgtc ggggccggcg
    23581 aggcgccggg tggcctcgat gccgtccatc agcggcatcc ggatgtcgaa caggccgacg
    23641 tcggggcgca gccggagcgc caggcggacc gcctcgcgcc cgtcggcggc cgcgccgacc
    23701 acctcgatgc cgggttgggc gtcgagcagc atggtcagcc cggtgcgcac gatgggctgg
    23761 tcgtcggcga cgaggaccct gacgctcatc atggcgtccc ggttcggggc aggaccgcct
    23821 ccacccgcca gccccgcccg gcggcggggc ccgcgtggaa ggtgccgccg agcagcgagg
    23881 cgcgctcccg catgcccacc aggccgtagc ccgccggggc gcggccgccg gcggcggagc
    23941 cgtcgtcgtc gacggtcagc cgcacctggt cggcgtcgcc tgtgacggcg acggtgacct
    24001 tcgacgcgtg ccgggcgtgc cgccgggcgt tggtgacgga ctcctgggcc aggcggtaga
    24061 tcgcggtccc gaccgccggg ctgaggtcgt cgaactcgcc ggacagcgtc accttgacgc
    24121 aggggcgcgt ccggccatcg gtggcgagct gctcgacctc ggccacaccg ggctgcggcg
    24181 cgaacccggc gtcctgcgtg gcgcggagca cgccgacgat ggcgcgcagc tcggtgaggg
    24241 tgcggctcgc cgcgtcctcg atgacggcca gggcctcgac ggcacgctcg gggtgggagg
    24301 ccgcgacggc acgtcctgcc tgggcctgga tggcgatgcc cgtgacgcgg tgggcgacgg
    24361 tgtcgtggag gtcacgggcg agctgttcgc gttcgcgggc cttggcgtgg tcgatgtcgc
    24421 ggatgcggat cttcgtgcga tagcggatcg cggtgccgag cgcggcggcg aacaggaaga
    24481 acgcgtatcc cgcgaccacc tccgccaggg tggtggggtc ggcgccgagg gcggtgatga
    24541 gggccggcca gagcaggatg acgccgaggc cgctcgcggc ttcccggccg gagccccacc
    24601 ggaacaaggc gtaggccagg atcagcaccg cgatgccgct gttcagcagg gcgccctgcg
    24661 tcccggtgag gactctgacg acgtcgatga tcgtcaacgt gccgcaggag accacgaccg
    24721 cgacgagcgg gtgcgtgcgt cgccacagca gtgggccgag gaccgcgagc accgcgagta
    24781 gcagcagcgg gcgtggcgcc aggtcctgac gaagcaccgc ttccgccacg gaccagcaga
    24841 tcagtaccgc gaccaaggcc cagtcccgcg gccccagggc cggggctttc gcgggtcgag
    24901 gttcggccca cagcgagcgg agtgcgttgg tggccatctg atgagcctag gcagcccgcg
    24961 ggctcaatgt atccgccgaa agtacaagag cccggctgtg ccaaaggcca ggtcaaacca
    25021 ggttccgcgg ccgatgtgcc cgccgccggc atccgtgagg gtggaagcac ccacccgatc
    25081 acagggagtc cgtgatgaga acgccccaat cccaagccgc accagagaat ccgtcgcccc
    25141 agagcacgct ggaggacctg cgcctacccg tgcaggccaa gctcgcagcg gcatggacca
    25201 gcttcatgtt cctctacatc tacgtcgact acctcgccct gtacaagccc ggcttcctcg
    25261 acgacctcct gggcggcacc gtccacgagt tcgacaccgg cccgaccttc gtcgccgtcg
    25321 cgctctcgct catggccgtc ccgatcctca tgatcctgct ctccgcgaca ctgcccgccc
    25381 gcgtcaaccg caccatcaac gtcgtcgtcg cagcgctcta catccccgtc tcggtgttca
    25441 acgcggcagg ggagccgttg tcctactcct acttctacgg cctctccatc ggacttgagt
    25501 tgctgctcct ggccttcatc ctgcgctccg cctggtcctg gccacgccgc atcacatcac
    25561 ctgcgaccct ggccaccacc ctcgacagcg agccgcagca ggcgtgacca ccccccgcgc
    25621 ctgaccatcc ctcgcccgcg ccacccgcga gcacggatgg tcatgccggc aatgccccag
    25681 cgctcgccca gagcggcaga acaccggccc ctctcccctt cgcgtacctc cagcttttcg
    25741 ccctgagcac ccggaaccgc ggcacggtca tcgcgtcctc gtcgcctctg cgagagcttg
    25801 gtcgcgatcg acgtggacga gacgccgcta cctagtcgag gacgccgcgt ccggggcctg
    25861 aatgggggac tgcggggtta accggtcgcc tgaacgaaga cgccgaccga ggcaccagaa
    25921 catgatcgcc ccagcggcac ccaccccctg ccggtcccta ggccgaagcc accgcatgaa
    25981 cgcagcaggt gaggggcttc gacccgcgag gagaccaagc catgccatca acggcatccg
    26041 cggggaatta tcctggcggg gtagac
//
