LOCUS       NZ_WOFH01000001        24734 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Actinomadura litoris strain NEAU-AAG5 Scaffold1, whole genome
            shotgun sequence.
ACCESSION   NZ_WOFH01000001
VERSION     NZ_WOFH01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura litoris
  ORGANISM  Actinomadura litoris
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 1015624)
  AUTHORS   Cao,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2019) Northeast Agricultural University, College
            of Life Science, No. 600 Changjiang Road, Harbin, Hei Longjiang
            150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 109x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009733595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 03:46:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,194
            CDSs (total)                      :: 8,115
            Genes (coding)                    :: 8,044
            CDSs (with protein)               :: 8,044
            Genes (RNA)                       :: 79
            rRNAs                             :: 5, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 1 (5S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 14 of 71
            Pseudo Genes (incomplete)         :: 60 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:00:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 448967
            Orig. end                         :: 473701
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WOFH01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24734
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24734
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24734
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14734](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14734
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            233..1114
                     /locus_tag="GNZ18_RS02035"
                     /old_locus_tag="GNZ18_02040"
     CDS             233..1114
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF016550.5"
                     /locus_tag="GNZ18_RS02035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02040"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_173390604.1"
                     /transl_table=11
                     /translation="MTDKATFDWAAARADLDGFDTARAMMARLWNLWAGGKDAFPGDRE
                     FCDRAQETYPQITRLARYRLVFRARVVRALMSRYGIDQFLIVGTDLPLHSEVHDIVHRA
                     APLARVVYADSDVWVIRTAEALLNPLPGSVCGYVSAGLDDPAALLEDTARWLDLERPVG
                     VVMLNSLDVLPDLSAAAALKVLRAALAPGSCLAFCALTDDGYETRLFEAMGAGQYPCLA
                     LPRSRAAVQDLLAGTRLLAPGVVPVSRWCPEWRWPELDTDDLWCGVGQILDQDEDVAAA
                     RSQLTDTTARRS"
     gene            1750..2244
                     /locus_tag="GNZ18_RS02040"
                     /old_locus_tag="GNZ18_02045"
     CDS             1750..2244
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01549.1"
                     /locus_tag="GNZ18_RS02040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02045"
                     /product="HAD family hydrolase"
                     /protein_id="WP_173390605.1"
                     /sec_met_domain="HAD_2 (E-value: 5.7e-10, bitscore: 35.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSTPITTAAIALDYGKTISLDHVDPAFGQKPVDPGAAETLRVLY
                     GRKKRLILASNTLPSESRWPALQAAGIDDVFTLALLSHSLGVGKPDPLFYHLVIAAADC
                     PAQEILFVGDHLVNDVLEPMGHGMRAALVRQDGLRADEELPDGAVLIRHVRELPELLAE
                     Q"
     misc_feature    complement(2362..2375)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.89"
                     /tool="antismash"
     gene            2403..4511
                     /locus_tag="GNZ18_RS02045"
                     /old_locus_tag="GNZ18_02050"
     CDS             2403..4511
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS02045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GNZ18_02050"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_173390606.1"
                     /transl_table=11
                     /translation="MLLPAPPGRIRDRERERSLLVVVAARYLTPDRGEGRGEVGVRPDL
                     LVISGPGGVGATALAADLAHRAVHAGSAPAGALWADLSALGKAEIAPAATGAVLAGWLR
                     TLGAAWIPAHPGEAAAMLRSLTTDGVVAVIDRATSAAQVRALLPATGLVIVTSRHRLPE
                     LAADGAHNVELGSLPFDAGMDVAADVIGSRATADPAGLRALVAACGGLPAAIVAAASYV
                     AARPHRPIGELAARLSRPRLRPCPPRAMAGRDDPPLSSTPEHTVTVAEEENIVNAAVDA
                     AYSELSPQLQHAYQVLAVLPGPIFSTDAAAAALQLRDEATDSVLAHLRQAHLVQHEIGD
                     QWRLRDPTQAARLVGQMAADEHDAVVATAARHYLMWAAGIDTAMSQRRRYAAVFTWHPE
                     RPSAVTGRQAAIAAMQPWVATLLASQAAAADAGQHYLAWQFTDVLWGYVIHRQDYATGQ
                     QVCQVALDSARRCGDVGAQARIHMLAGALARRQGHLDAALDHHAVSDELARQAGDTLSC
                     AATREHLGATLRELGRPDEAIAVLETGLALYDASPPYPRGRALLLRQLGAALSDRGRHH
                     EAAPHFAEAEQIFVNLGEEYPRARLALNQAEAAINRGDFDQALDRLDLAADLLPDSSAP
                     HDGYLHCLYAKAHTGTGDTDAARRALATAEHLGAALPADHPTAHFIRSIRDDLAATGPE
                     VNSDANPV"
     gene            4575..5429
                     /locus_tag="GNZ18_RS02050"
                     /old_locus_tag="GNZ18_02055"
     CDS             4575..5429
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS02050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GNZ18_02055"
                     /product="hypothetical protein"
                     /protein_id="WP_156214343.1"
                     /transl_table=11
                     /translation="MSETETWDKPVILRVGTYNLFEGGLANLADHNQSGDIGEPDLDDS
                     RLRKQLGLLSRHNFDVVGLQEATWGVHSPQLEKLVAAELGMRWSFVGRSNFYGCDLATF
                     VRTGDNLTVEHVEHLTGAPFVHGLTNVTVRVNGRRRPIHVLVGHSAPSSPGVRHLEAET
                     ITVHRHLDVIYLCDHNSAALDDNPKTTGLDPYKTAKKLDTTPAQELDAAGFRDVGRVWK
                     DPTPTVGHGTPNEDGGGDHLAYRCDQVRTTLPTACITGYGVELNGDKWSDHRLVWAEFT
                     IGR"
     gene            5476..6354
                     /locus_tag="GNZ18_RS02055"
                     /old_locus_tag="GNZ18_02060"
     CDS             5476..6354
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS02055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GNZ18_02060"
                     /product="hypothetical protein"
                     /protein_id="WP_156214344.1"
                     /transl_table=11
                     /translation="MTNSALDVEPFGSTDPTARIDHLYRLRRATHHFIVRYGEAHWAEE
                     QRFSGRLTAPPTITALPARRRPKALAADEARRVADAHLYGLDEVAATTAVTLGARMVEF
                     TSSDADPDVDRAWSPVARPPAESGLLWWAGGIGYDNLGVPLVAAHWGPMAEGTWLAFWA
                     DNRAVVQNEMAQHGWTRSQAHLVLQEFGPLATTGIAAGLSPRLDAKPPPDPGARQPPPP
                     TDSPLALTATVAASWALLTTPGAARLITREPDPDEAVRDRRAGLTPRPATLAAAPIDPQ
                     ILQRLYTQEQR"
     gene            6483..6812
                     /locus_tag="GNZ18_RS02060"
                     /old_locus_tag="GNZ18_02065"
     CDS             6483..6812
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS02060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GNZ18_02065"
                     /product="hypothetical protein"
                     /protein_id="WP_173390607.1"
                     /transl_table=11
                     /translation="MGALAAQAEITMKIVRGGGLDDLPLPGVVDALGCLMHNVEVLHQL
                     VAAVNERAAQIREREVTERPAGTTLETMDSALMTLGYGQETAMSMHRLLSLGHRELVLV
                     DEGEV"
     gene            6909..7481
                     /locus_tag="GNZ18_RS02065"
                     /old_locus_tag="GNZ18_02070"
     CDS             6909..7481
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS02065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GNZ18_02070"
                     /product="hypothetical protein"
                     /protein_id="WP_156214346.1"
                     /transl_table=11
                     /translation="MTITPEKPVTAAQPDQINQVGRDPRELIPAPAFALLVEDVRKATH
                     ATHDYCQRVVGQHLVFLKAVGEIRRAERQDPSNYVRIVPTPPVDQAWHLSLQRTEVYVP
                     MSYRFAESFIHHRPVMDDDIRSGTALARTIPRLHATGYYVDPEFWEGEAGASCCPPDCN
                     DMDGRGWRSVVDWSGHLPLEAPLTIAI"
     gene            7478..8308
                     /locus_tag="GNZ18_RS02070"
                     /old_locus_tag="GNZ18_02075"
     CDS             7478..8308
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.5"
                     /locus_tag="GNZ18_RS02070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02075"
                     /product="phosphotransferase"
                     /protein_id="WP_173390608.1"
                     /sec_met_domain="APH (E-value: 2.1e-09, bitscore: 33.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEKEPRVRTDWSDLPEDLRTEIEAHTGPVVDVEPAPTGNHADIA
                     STLYTTGGPVFVKAARKLADRDGPEVKSLRREASVNPVVTELAPRLRWQVEAGEWLALG
                     FDHVQGRPADFSPGSPDLDVLAKTIQAIHNAPCPDAVRLVVERRWQKHTADVAFLAGHT
                     LLHTDLNQDNFIITSDGRAYVVDWAFVSRGAAWVELGLLIPWLLKAGHSPNEAEAWVSQ
                     FPSWEQTAAADIDTFAAAFAMQWRKASQMREDPWVHLHADLTGRWDDHRRQLAT"
     misc_feature    7736..7738
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8389..8399)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            8448..9731
                     /gene="fxlM"
                     /locus_tag="GNZ18_RS02075"
                     /old_locus_tag="GNZ18_02080"
     CDS             8448..9731
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629699.1"
                     /locus_tag="GNZ18_RS02075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02080"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_312874250.1"
                     /sec_met_domain="PCMT (E-value: 1.6e-30, bitscore: 102.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVDTASRADRAEELRNALVDTIITDHRGKGLAMPAEVEAAMRTV
                     PREVFTPGVTLEEAYENTAVITARRGEEAVSSVSAPYLIAEMLGQAVEALGGLEGRAVL
                     EVGSGGYNASLLRELVGPSGSVTTVDIDPEVTDRAASCLERAGYNDVTVVCADAEHPVE
                     PARRYDLITVTAGAWDIPPAWREQLAEDGVLVVPLRTWGLTRSWALRRSGDRLTSLSHR
                     QCGFVSMRGDGGRSLRYVDVAEGVHLRLDEDTLAAPDALARTVGDLLSQPREVAWAGVS
                     LPPRTMLSNLDLWLATRFAGEAGEFMVLTAQEEAVESGIVAPSWRFGAPAALVEGTFSY
                     RSALKWTDRRFDLGATAHGPAAAAAAERIVEHMRAWLNAASPIPALEVLPARTPDGDLP
                     DGTVLDKRHSRIVLSFPTVISQPEGTNS"
     gene            9731..9883
                     /locus_tag="GNZ18_RS02080"
                     /old_locus_tag="GNZ18_02085"
     CDS             9731..9883
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="GNZ18_RS02080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02085"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_156214349.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.3e-13, bitscore:
                     46.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHDEQYDLNIRLVDSGDVASGHATSTDDNCGSGNTDSDACTTNA
                     DAGVR"
     gene            10001..12874
                     /locus_tag="GNZ18_RS02085"
                     /old_locus_tag="GNZ18_02090"
     CDS             10001..12874
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629697.1"
                     /locus_tag="GNZ18_RS02085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02090"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_156214350.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.8e-12,
                     bitscore: 42.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.1e-94, bitscore:
                     310.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.2e-15, bitscore:
                     51.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFHATSAALIRAAAYPDDLVLPAWPDLAADQPGPWREWLEEAWAL
                     PGFAPAVTSAAPDLAAQIGRVLDGQAMQTRRLRRLVEATIRYLLRWTTRATPFGRFAGV
                     APVELGPRAAVHWSGRHRAAARPDDRFIAEQTARAERELPVLRAVAVMTNPLGYARGGR
                     WVLPCARTEQDRMWDVEIELTEPVRAAVERAVSAVAFTDLAVTVADKLPDGMAEAERLL
                     AALVNAGVLVSAIRPPMTVTDPSAHLTRHLADHAAGRLDLPDPGDQIAVDLRVGCSVTL
                     PPAVVAAAEDAASTLTAVAPRLPGWTVYHRAFIERWGPGAAVPLREVVNVLGFPAGYRS
                     SARRDPAAFTARDALLADLAQQSALDGCADVLLDDDLIAALRGEDPRPPIPHTELRFTL
                     TAPTPRHLDRGAFTLTVVSGARHAGVAAARFLYLLTPDELERFRSVYTCLPAAMPGADI
                     VQLSAPPLDAGLATLARTPQVLPVLPVGDFHPAPSWTLADLAVAGDGERLWLVSATTGR
                     PVEPLLFNCVMLPTAQQPLVRFLTEIWTAWTAPCARFDWGHATGLPFLPRVRRGRAVLH
                     PARWSVRAAALPGRTTSWPQWRDAWQRYRERHRLPHQVLISAGRGVDDVRLRLDLDETA
                     HLVLLRSHLHRHDAAVLTEADGPSGWIGGRPAELLLTLTSTPPHPRRPPRPSRPTGILQ
                     HLPGRSRWLDARVFGRSQTTITDILTRLPELPAGWWFLRYPDPTPHLRLRIPLRDRNHF
                     AAITHDLAQWAEQLHNNGLVNDYALATYRPETRHGSGPALAAAEAVFAADSRAVLGRLS
                     GELEAAAAAGMITIAHGFTGGDGLRWLVDHVPHRSGPRLEPAQLARARHPHHGPDHELA
                     TELATALATYRAIAARDGLDTDQVLADLLHLHHARMIGVDTASERHCLRLARTIAHTHL
                     HTNRNSYMRTNLHDQDTRGRDPISRTS"
     misc_feature    10229..10231
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10451..10714
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GNZ18_RS02085_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.20E-13"
                     /identifier="RREFam001.1"
                     /label="GNZ18_RS02085"
                     /locus_tag="GNZ18_RS02085"
                     /protein_end="238"
                     /protein_start="150"
                     /score="42.5"
                     /tool="antismash"
                     /translation="VMTNPLGYARGGRWVLPCARTEQDRMWDVEIELTEPVRAAVERAV
                     SAVAFTDLAVTVADKLPDGMAEAERLLAALVNAGVLVSAIRPP"
     gene            12871..13944
                     /locus_tag="GNZ18_RS02090"
                     /old_locus_tag="GNZ18_02095"
     CDS             12871..13944
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629696.1"
                     /locus_tag="GNZ18_RS02090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02095"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_156214351.1"
                     /sec_met_domain="LANC_like (E-value: 8e-35, bitscore:
                     116.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTGQNLADGAAGIALLHLETGDWEAAYTALREAVADGVSIAGGA
                     SLYYGAPALAFVLAASDRADLTRAKAVAAAGTATVTRRRLEAAHRRIDQRQRPPYAEFD
                     LIGGLTGLGVALRRIGDLDLLRDVLTYLVRLTEPLDGLPGWWCPTGPHRTKPGPPGGHS
                     NHGMAHGITGPLALMALTLRDGMHVPGQPAAIARICTWLDQWEQQTDDGSAWWPQTITL
                     EELHYGDTDQPGPLRPSWCYGTPGIARAQQLAGHALSDTARQRKAEKAFTACVSDHEQL
                     VLLTCRSLCHGTSGLLAAGRRIAADAHAPISAPLPLDLHPKPAPPGEPPGFLNGTAGAE
                     LTTTGTVTSWDACLLLC"
     gene            13961..14734
                     /locus_tag="GNZ18_RS02095"
                     /old_locus_tag="GNZ18_02100"
     CDS             13961..14734
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629695.1"
                     /locus_tag="GNZ18_RS02095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02100"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_156214352.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-17, bitscore:
                     60.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEPPCETSSWTQVNIAFPGHNARERERRAAAHLVRILPAAEADG
                     RITSWFFTRKTRWRIRYRPAKASDSRPLRSLLTQGVDSTNDIYEPEVHAFGGHPSMETA
                     HQLFHADSHHLLTFLNGAPTDRRERSLILLTTLMRAAGLEFGEQGDVWARVAEQRSPLR
                     SDLPEPATWASFTHGVRHLLLGKPRPDDIGSHWLTAFETAGGQLKDLRERGQLTRGIRA
                     ITALHVIFHWNRIGLTGPTQAELAQAVKEAILAPY"
     gene            15245..17701
                     /gene="hsdR"
                     /locus_tag="GNZ18_RS02100"
                     /old_locus_tag="GNZ18_02105"
     CDS             15245..17701
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0015666 - restriction
                     endodeoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene="hsdR"
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_185101612.1"
                     /locus_tag="GNZ18_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02105"
                     /product="EcoAI/FtnUII family type I restriction enzme
                     subunit R"
                     /protein_id="WP_216651119.1"
                     /transl_table=11
                     /translation="MTSSNGPLEDETCKRFVLPALDRAGWGEDQIKAQYRINRGRIQPT
                     ARRHRQERPLVADYLLEYSDGLPLAVVEAKRSRRDPAAGFEQVKRYAALLDVPFAYTTN
                     GTKTLEIDSCTGLTTEITEFPAPEDLWTRYCATRGLNEDFQTALASAPFNHNVRNWDNT
                     PKEPRYYQRNAINRAVQAIAQGERRVLLVLATGTGKTLVASQIVAKLWNASWPGDRRPR
                     VLYLADRNILVDQPKDDYFERMFGEAVHKLTRGVALTSRNIYFALYQSLTRGGDAEDLY
                     QQFDRDFFDVIVVDECHRGSATEGSQWREVLDHFHSAIQLGLTATPISKRDADTYGYFG
                     DPIYEYTLAQGIQDGFLAPYRVRNVRLDLDLFGWRPSEGQLDMYGREIPDELYGPREFE
                     RIVAVLDRTDAAARYLTEYLHKTNRMAKTIVFCQTKDHALRMVQALHNANADLVRQYGN
                     SYVCRITSDDGDAGRERLGEFRDDSTQIPTIAVTARLLSTGVDIPTVRNIVIFRVIRSM
                     PEFKQTIGRGTRLSPETDKYAFDIIDFVEATRLFYDPDFDGPPIRRLRDETDDEGNIVT
                     TIAEDLTDPDPDPDSDAAAEPEPEYEEQDRGGLPPTIVTDPDEIDDIRAQGSTYYVDDV
                     PVTVFGTAMYVTETDGSGTRLRLVSIEQYIRGRLRELDLSPHQLLTQWAQTESRKELRD
                     RLDEFGITPADLGELTGRPDADTIDLLIYIGWDLPVLSRSERALRFKLRHRNFLESFAD
                     DAREVLDRVLEQYSTRGAEELDVQALRSPAYADLGTVVELASRFGGGAGLRSAIDALGV
                     QLYEAS"
     misc_feature    18096..18109
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            18116..19591
                     /locus_tag="GNZ18_RS02105"
                     /old_locus_tag="GNZ18_02110"
     CDS             18116..19591
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001926643.1"
                     /locus_tag="GNZ18_RS02105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02110"
                     /product="class I SAM-dependent DNA methyltransferase"
                     /protein_id="WP_156214353.1"
                     /transl_table=11
                     /translation="MAPSAKKDTTSRARLSAVIKSARDIMRKDAGLNGDLDRLPLLSWL
                     LFLRAFDALEAEREVTGEESIIKPDYQWRAWADDETFTGEDLLSFINNELIPYLRGLSS
                     DEPGDPRNVLSQVFGGVQNRMLSGYLFRDLVNQIRKIDFNSSDDIHTMAFLYESLLKEM
                     RDAAGDSGEFYTPRPVIRFMVEQTFPKLGESILDPACGTGGFLVEAYTELAPQATGRML
                     QQQLVYNLRGIEKKPLPYLLCMMNLTLHGISAPNILNANALRKMIADTSPSTQVDIILT
                     NPPFGGEEEDSIAKSFPSGYQTRETAWLFLHAVIRKLKPGGRCAIVLPNGALFGEGIGT
                     KIRKKLLQECNLHTIVRLPQSVFAPYTDIPSNLLFFEKTGPTKEIWFYQIDPPEGRKGY
                     SKTKPMRYEEYAACAEWWGGEERKERRENDHAWRVLISEIAESGYDLNILKPTVEASLP
                     HHPPVDILKEIISTENSITATLISLLEELDSEA"
     gene            19588..20724
                     /locus_tag="GNZ18_RS02110"
                     /old_locus_tag="GNZ18_02115"
     CDS             19588..20724
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013579.5"
                     /locus_tag="GNZ18_RS02110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02115"
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_156214354.1"
                     /transl_table=11
                     /translation="MKLPERPLGDAIRLNLMPVDVSAGTNYPIAGLYSFGRGFIRRPTI
                     DGSETAYSRLFRISKDQLVMSKLGAWEGAFAVVPDEFDGAFVSPEYPSFDIDSSVATTA
                     YIAHLVRWPAFWERVNPRGSMARRKRITPARLAEIAVPLPDLEEQRRIASRLDAAEERL
                     KEVGRQRDYSIKLHDSLRESMFSNEQLGEPARLGDVLTLERIPAIIDPEENYTQIGIRS
                     FGKGIFHRDGSLGSELSKLKYYEIRPGNLIVSNIMAWEGAIAVSSEADNGCIGSHRFLS
                     FKPTESVDIRYLSHFFQSRQGRELIKTTSTGTVLRNQTLSIKHFENLKVPLPPIGEQKR
                     VASILERSNVIQGRVATQGELSNTLTRSLLHAAFSGKL"
     gene            21467..>21628
                     /locus_tag="GNZ18_RS02115"
                     /old_locus_tag="GNZ18_02120"
                     /pseudo=""
     CDS             21467..>21628
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012393239.1"
                     /locus_tag="GNZ18_RS02115"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02120"
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTENRYRAVLEVLIGGPVTEVARRYGVPRQTIYVWCRRYRQDGVE
                     GLQGKSRRP"
     gene            21846..22190
                     /locus_tag="GNZ18_RS43965"
     CDS             21846..22190
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GNZ18_RS43965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216651120.1"
                     /transl_table=11
                     /translation="MSAAVLVPSLGAGLQGLGLGATADVESGLVLIERDRAVDRQIAGD
                     HDQIDIVLVVLASQGIDGVQEVPVDREIAVEEQHAVIVGRLSFALERGGQRAAQTGVGV
                     GIGQGCGGGG"
     gene            22462..23256
                     /locus_tag="GNZ18_RS02125"
                     /old_locus_tag="GNZ18_02130"
     CDS             22462..23256
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949000.1"
                     /locus_tag="GNZ18_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GNZ18_02130"
                     /product="transposase family protein"
                     /protein_id="WP_156214356.1"
                     /transl_table=11
                     /translation="MGGVLRAEPLWVEVFTGLRMTQFQRLVRAVRERGGNGPQKGPRIG
                     RPWCLPLADRVLLVAMYYRTNLTMRQLAPLFGTSPATVCRVVQRLGPLLALEPAPRPAE
                     PLERLWIVDGTLIPVCDRRVGSSSRNYRFSANVQVVVDADTRLVLAAARPVPGTTADAQ
                     AWRRSHLPEYCRGVTVLGDGAYTGCGLVIPHRKRPGRPLLPVQEADNAEHRKVRARVEH
                     TFARMKNYKILRDCRQRGDDLPNAVQAVAHMHNLAHTPAPAA"
     gene            <23319..>23988
                     /locus_tag="GNZ18_RS41675"
                     /pseudo=""
     CDS             23319..>23988
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_029622100.1"
                     /locus_tag="GNZ18_RS41675"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFPVPERVLGHSSTTRPSRRSWPGSTGRPACVLPGSAACSTSSAS
                     SPRAWASSSSPTASLLWTLRR"
     misc_feature    23628..23630
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            <23983..>24124
                     /locus_tag="GNZ18_RS43970"
                     /old_locus_tag="GNZ18_02140"
                     /pseudo=""
     CDS             23983..>24124
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012948682.1"
                     /locus_tag="GNZ18_RS43970"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="GNZ18_02140"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRDGGITPRIARPGIESAERLGRHRWMIERTLAWLLGYRRLTIRY
                     ER"
     misc_feature    complement(24250..24263)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: strong, score: 24.74"
                     /tool="antismash"
     misc_feature    complement(24649..24661)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.32"
                     /tool="antismash"
ORIGIN
        1 tggcctcggt cgccgccgct taccaagacc aactcggagt cggaacgctc cgcactaccg
       61 agcagatcac cgccctgttc ggtggctggg agttggtacc gccaggagtg acgcctctcc
      121 cagactggcg ccccgccgtc ggcgagcccg ctaccgaccg ggcagcggcg gagcttggcc
      181 tgggcggagt cgcgcgcaag cccgccagag tcgtcgagaa gggatgcgtg cgatgaccga
      241 caaagccacg ttcgactggg cggccgcccg tgccgacctc gacgggttcg acaccgcgcg
      301 ggcgatgatg gcccggctct ggaacctgtg ggcgggcggc aaggacgcct tccctggcga
      361 ccgagagttc tgtgatcggg cgcaggagac ctacccgcag atcacaaggc tggcgcgata
      421 ccggctggtg tttcgggccc gcgtggtgcg agccctgatg agcaggtatg ggatcgatca
      481 gttcttgatc gtcggcaccg atctaccgct gcattcggaa gtccacgaca tcgttcaccg
      541 ggccgccccg ctggcccgtg tggtttacgc cgactccgac gtctgggtca tccggaccgc
      601 cgaggcgcta ctgaatcccc tcccgggaag cgtatgcggc tatgtgtccg caggcttgga
      661 cgaccccgcc gcgttgctgg aagacaccgc ccgctggctg gatctggagc gccccgtcgg
      721 tgtcgtgatg cttaacagcc tggacgtgtt gcccgacctc tccgcagcgg ccgcgctgaa
      781 ggtgctacgt gccgctttgg cgcctgggag ttgcctggcg ttctgcgccc tcaccgacga
      841 cggctacgaa acgaggctgt tcgaggctat gggtgccgga cagtacccct gcctcgctct
      901 gccccgtagc cgggctgctg ttcaagatct cctcgctgga acacgactcc tggcacctgg
      961 ggtcgtgccg gtatcccgtt ggtgtcctga gtggcgttgg cccgaactcg acaccgacga
     1021 cctgtggtgc ggcgtcggcc agatcctcga ccaggatgag gacgtcgcgg cagctcgaag
     1081 ccagctcacg gacaccacgg ctagaaggtc gtgatggacc cccaaccaat ctcgggtgcc
     1141 gaccccagag cgccgatgga ccgcgttctg tcccggcccg ccgcctctgc cgatccctac
     1201 cacgccccca gagagaggac cagcactcat gccacatgag aagcacccgc ccacccctga
     1261 cctcggttct gccgacgatc cgcgcctggc tgagacactc ggaacgagcc tgcgtctaca
     1321 agccgccctt cagtaccgcg ccccacgact ggaactccgc accggcttcg acggtgagac
     1381 cggctgctat ctgtctgtcc tttgcagaga cggggcgatg cgcatcgcat gggccgggac
     1441 gacctaccgg tggagagccg agcccgatgg cccttgggag cggctgtctg cggacccggt
     1501 tcaggctgcg gacgatatcg cgctggggct cgacgtggac cgacgtcgcg ggcggcggca
     1561 cgtgctagcc accctggcga ccgcagcccg cggactcatg cgcggcacac cccgatagcc
     1621 gcctacagcg catagcccag ccgtcatttt cctgattctt gtctggccag gggcgtcagc
     1681 ccgcacttgg gatcttccgc cctcgtcatg cgattccctc tccggccggg cgagccaaca
     1741 gttcggagca tgatgtccac gccgatcaca accgcggcca tcgcactgga ttatgggaag
     1801 acgatctccc tcgatcatgt cgatccggca ttcggtcaaa agcccgtcga tcccggcgcg
     1861 gccgagacgt tgcgcgtgct gtacgggcgc aagaagaggc tcatcctcgc gtcgaacacc
     1921 ctgcccagcg aaagccgttg gccagcactc caagccgccg gtatcgacga cgtgttcacg
     1981 ctggcgctgc tctcccattc gcttggcgtc gggaagcccg atccgctgtt ctatcacctg
     2041 gtcatcgccg ctgcggactg tccagcgcaa gagatcttgt tcgtcggcga ccacctggtc
     2101 aacgacgtgc ttgagccgat gggccacggt atgcgtgcgg cgcttgtgcg ccaggacggt
     2161 ctgcgggccg acgaggaact tcccgacggc gcggtgctga tccgccacgt ccgcgagctg
     2221 cccgaactgc tggcagaaca gtgaccacca ccggatccag caccgcgcct accagcgagc
     2281 ccctcaccgg ctcacagaac aggcttgagg caggggcacc ggtcggcacg atggtgcagg
     2341 ccgccaccgt ccacggcggt gtgcatgtgc acacggccgt ggacgggagt agacggccgc
     2401 cgatgctgct gcccgctcca cccggccgga tccgtgaccg ggaacgtgag cgcagcctcc
     2461 tggtagttgt ggcggccagg tacttgacgc ccgaccgagg tgaagggcgc ggcgaagttg
     2521 gtgtacggcc ggacctgctg gtgatcagcg ggccgggcgg tgtcggcgct accgccctgg
     2581 ccgccgacct cgcacaccgg gcggtccacg ccggatcagc gcccgccggc gccctgtggg
     2641 ccgacctcag cgccctgggc aaggcggaga tcgcccctgc cgccaccggt gccgtgctcg
     2701 cgggctggtt gcggacgctg ggagccgcct ggatccccgc ccacccaggc gaagccgccg
     2761 cgatgctgcg gtcgctgacc acggacggtg tcgtggcggt catcgaccgt gcgaccagcg
     2821 ccgcgcaggt gcgggcactg ctgcccgcca ccggcctggt catcgtcacc agccgccacc
     2881 ggctgcccga gctggccgcc gacggcgccc acaatgttga gctgggctcg ctgccattcg
     2941 acgccgggat ggacgtggcc gccgatgtca tcggttcccg cgccaccgca gacccggccg
     3001 ggctccgcgc gttggtggcc gcgtgtggtg ggctccccgc tgcgatcgtc gccgccgcat
     3061 cttacgtggc tgcccggccg caccgcccca tcggtgaact ggccgcccgc ctctcccgac
     3121 cccgcctccg tccgtgcccg ccgcgcgcca tggcgggccg tgatgatcca ccgctttcca
     3181 gcaccccaga acacaccgtc accgtcgctg aggaggagaa catcgtgaac gccgctgtgg
     3241 atgccgccta ctccgaactg tccccccaac ttcaacacgc ctaccaggtt ctggccgtcc
     3301 tgcctggccc gatcttcagc accgacgcgg ccgcagccgc gctccagctg cgtgacgaag
     3361 ccaccgacag cgtgctcgcc cacctccgac aggcgcacct ggtgcaacac gagatcggcg
     3421 accagtggcg gctgcgggac cccacgcagg ccgcgcgcct ggtcggccag atggcagccg
     3481 acgagcacga tgccgtcgtg gccaccgccg cccgccacta cctgatgtgg gccgccggca
     3541 tcgacaccgc catgtcgcaa cgtcgccgct acgccgcggt tttcacctgg caccccgagc
     3601 gtccctcggc cgtgaccgga cgccaggccg cgatcgcggc gatgcagcca tgggttgcga
     3661 cgcttctcgc ctcccaagcg gccgcggccg acgcgggcca gcactacctg gcctggcagt
     3721 tcaccgacgt gctgtggggc tacgtcatcc accggcagga ctacgccacc ggacagcagg
     3781 tctgccaggt cgcgctggac tcggcccggc gctgcggcga cgtgggcgcc caggcccgca
     3841 tccacatgct ggccggcgcc ctggcacgac gccagggtca tctggacgcc gcgctggatc
     3901 accatgccgt cagcgacgaa ctcgcccgcc aagccggcga caccctctcc tgcgccgcca
     3961 ctcgcgagca tctcggggcg acgctgcggg agctgggacg tccggatgag gcaatagccg
     4021 tcctggaaac ggggctcgcg ctttacgacg cgtcaccgcc ctacccccgt gggcgggcac
     4081 tgctgctccg ccaactcggc gccgccctga gtgaccgagg acgccaccac gaagccgccc
     4141 cacacttcgc cgaggccgaa cagatcttcg tcaacctcgg cgaggagtac ccgcgcgccc
     4201 gcctcgccct caatcaggcc gaagcagcca tcaatcgcgg cgacttcgac caagccctcg
     4261 atcgcctcga cctcgccgcc gatctccttc ccgactcctc cgcaccccac gacggatacc
     4321 tgcactgcct gtatgccaag gcccacaccg gcaccgggga caccgacgcc gcccgccgag
     4381 ccctggccac cgccgagcac ctcggggcag ccctccccgc cgaccacccc accgcccact
     4441 tcatccgctc gatcagggac gacctggccg ccaccggccc ggaggtcaac tcggacgcta
     4501 atccggtctg atggccgccg ggcttccctg tcagagcgcg cagatcctcc acaaacttct
     4561 cgctgggagc acgcatgtct gaaacggaga cgtgggacaa gcccgtcatc ctccgggtcg
     4621 gcacctacaa cttgttcgaa ggcggcctgg ccaacctcgc cgaccacaac cagtccggcg
     4681 acatcggcga gcccgatctc gacgattccc gcttgcgcaa gcagctcggg ttgctgtcac
     4741 gccacaactt cgacgtggtc ggactccagg aggccacctg gggtgtgcac tcgccgcagc
     4801 tggaaaagct cgtcgccgcc gagctcggaa tgcgctggtc gttcgtgggc cgctcgaact
     4861 tctacggttg cgacctggcg accttcgtcc gcacaggcga caatctcacc gtcgaacacg
     4921 tcgagcacct gaccggtgca ccattcgtcc atggcctcac caacgtaacc gtccgggtta
     4981 acgggcgccg tcggcccatc catgtcctgg tcggccactc agcccccagc tcccccggcg
     5041 ttcggcatct tgaggccgaa acaatcaccg tgcaccggca cctcgacgtg atctacctat
     5101 gcgatcacaa ttccgcggcg ctcgacgaca acccaaagac caccggactc gatccctaca
     5161 aaacggccaa gaagctcgac accaccccgg cgcaggagct cgacgccgcc ggtttccgcg
     5221 acgtcggccg cgtctggaag gacccgaccc cgaccgtggg gcatggaacc cccaacgagg
     5281 acggcggtgg tgatcatctc gcctaccgat gcgaccaggt ccgaacgacg ctgcccaccg
     5341 catgcatcac cgggtacggc gtcgagctca acggagacaa atggtccgac caccgtctcg
     5401 tgtgggctga gttcaccatc ggcagatagc gccgccccca gatccgccta tccccggagc
     5461 agagatccat tccgcatgac caattccgcg ctcgacgtcg aaccgttcgg ctccaccgat
     5521 cccaccgcgc ggatcgatca cctgtaccgc ctgcgccgcg cgacccacca tttcatcgtc
     5581 cgatacggcg aagcccactg ggccgaggag cagcgattct ccgggcggct caccgccccg
     5641 ccgaccatca ccgctctccc cgcccgccga cggcccaagg cgctggcggc cgacgaagcg
     5701 cgccgcgtcg ccgacgcaca cctctacggg ctggacgagg tggccgccac caccgccgtc
     5761 accctgggcg cccgcatggt cgagttcacc tccagcgacg ccgacccaga cgtcgaccga
     5821 gcgtggagcc ccgttgccag accacccgcc gagtccggcc tcctgtggtg ggccggcggc
     5881 atcggctacg acaacctcgg tgtcccgttg gtcgccgccc actgggggcc gatggcggag
     5941 ggcacatggc tggcgttctg ggccgataac cgtgccgtcg tccaaaacga gatggcccag
     6001 cacggctgga cacgtagcca agcccatctc gttctgcagg agttcggccc cctggccacg
     6061 accgggatcg ccgctggtct cagcccacgc ctggatgcca agccgccccc cgatcccggc
     6121 gcgaggcagc cgcctccacc gaccgactct ccactcgcgc tgaccgcgac cgtcgcggcc
     6181 tcgtgggcgc tgctgaccac gcccggcgcc gcccgcctga tcacacgcga acccgacccg
     6241 gacgaggccg tccgcgaccg ccgagccggg ctcacgcccc gccccgcaac cctggccgcc
     6301 gcgccgatcg accctcagat cctccaacgc ctgtacaccc aggagcagcg gtgaaccggg
     6361 accgaggcat gcaagagcaa cgacctccgc gcgagcaggt ccctccgaga caagctccac
     6421 gagagcaggc tccgcaggag cagaaggctg cgccaaggcg aggaggggac attctgacgg
     6481 ccttgggcgc ccttgctgcc caggcagaga tcacgatgaa gatcgtgcgc ggcggcggcc
     6541 tagacgacct gcccttgcct ggggtcgtgg acgcgctggg atgcctgatg cacaacgtcg
     6601 aggtgctcca tcagctggtg gcggcggtga acgaacgcgc ggcacagatc cgagagcgag
     6661 aggtcaccga acggcccgcc ggaaccaccc tggaaacgat ggactcggcg ctgatgacgc
     6721 tgggctacgg gcaagagacc gcgatgtcga tgcatcgcct gctatcgctg gggcaccgcg
     6781 aactggtcct cgtggacgag ggcgaggtgt gatcagcccc tgaccatctt cctggccccc
     6841 gagccagttg acacccgatc cacccagagg ttggacagac acaagagagg cgcgcacagg
     6901 aggttcccat gacgatcact ccagagaagc ccgtaactgc cgcccaaccg gaccagatca
     6961 accaggttgg ccgtgacccg cgtgaactga tccctgctcc tgcgttcgct ctactggtcg
     7021 aggacgtccg caaagccacg cacgccaccc acgactactg ccagcgcgtc gtcggccagc
     7081 acctggtgtt cctcaaggcc gtaggtgaga tccgccgcgc cgagcgccaa gacccgagca
     7141 actacgtccg catcgtcccg accccgccgg tagatcaggc gtggcacctg agcctccagc
     7201 gcaccgaggt gtacgttccg atgagctacc ggttcgccga gtcgttcatc caccaccgac
     7261 cggtcatgga cgacgacatc cgatccggta ccgccctcgc ccgcaccatc cctcgactgc
     7321 acgccaccgg ctactacgtg gacccggagt tctgggaggg cgaggccggg gcgagctgct
     7381 gtccgcctga ttgcaacgac atggacggcc gaggctggcg atcggtggtg gactggagcg
     7441 ggcacctgcc gctggaagcc ccactcacca tcgccatttg agcgagaagg agccgcgcgt
     7501 gcgcacggac tggtctgatc tgcccgagga cctgcgaacc gagatcgaag cccataccgg
     7561 ccccgtcgtc gacgtcgaac cggcccccac gggcaaccac gcggacatcg catccaccct
     7621 gtacaccacc ggcggccccg tgttcgtcaa ggccgcacgc aagctggccg acagggacgg
     7681 tcccgaggtc aagtcgctgc gccgcgaagc ctccgtcaac cccgtagtga ccgagttagc
     7741 tcctcggctg cgttggcagg tcgaagccgg ggagtggctc gccctcggct tcgaccacgt
     7801 gcaaggacgc cccgccgact tctctccagg gtcgcccgac ctggatgtgc tggccaagac
     7861 catccaggcg attcacaacg ctccgtgccc cgacgcggta cgactggtcg tcgagcgacg
     7921 ctggcaaaaa cacactgctg acgtggcctt tctagccggg cacacgctgc ttcacaccga
     7981 cctcaaccag gacaacttca tcatcacctc cgacggccgc gcctacgtgg tggactgggc
     8041 gttcgtatcc cgcggtgccg cctgggtgga gttggggctg ctgatcccct ggctgctcaa
     8101 ggccggccac tcgccgaacg aagccgaggc gtgggtttcc cagttcccgt cctgggagca
     8161 gactgcggcg gccgacatcg acaccttcgc cgcggcgttc gccatgcagt ggcggaaggc
     8221 gagtcagatg cgcgaggacc cttgggttca ccttcacgcc gatctgaccg ggcggtggga
     8281 cgaccaccgc cgccagctgg caacgtgaaa ccgactatca ccaccccgcc cgttccctcg
     8341 accacgccaa agggcggatg gtcgaacagc gacaaggagg ctctcttcgt gacatcgcac
     8401 cgtcgccggt tcgcacaccg gttcgtaccg acccggggaa gtgcgtcgtg agcgtcgaca
     8461 ctgcaagccg tgccgaccgg gccgaggagc ttcgcaacgc cctggtcgac acgatcatca
     8521 ccgaccatcg gggcaagggt ttggcgatgc ctgccgaggt ggaggcggcg atgcggacgg
     8581 ttcctcgcga ggtgttcact ccgggcgtca cgttggagga ggcgtacgag aacactgcgg
     8641 tgatcaccgc ccggcgtggt gaggaggcgg tcagttcggt atcggcgcca tacctgatcg
     8701 ccgagatgct cggccaggcg gtcgaggcgc tcggcgggtt ggagggccgc gccgtcctgg
     8761 aggtcggcag cggcggctac aacgcctcgc tgctgcgcga gctcgtcggc ccgtccgggt
     8821 cggtcacgac cgtcgacatc gaccccgagg tgaccgaccg ggccgcctcc tgcctggagc
     8881 gggcgggcta caacgacgtc accgtggtct gcgcggacgc cgagcacccg gtcgagccgg
     8941 cccgccgcta cgacctgatc accgtgactg cgggggcctg ggacattcca cccgcgtggc
     9001 gcgagcaact cgccgaggac ggtgtcctgg tcgtccccct gcgcacgtgg gggctgaccc
     9061 ggtcgtgggc actgcgacgc tccggagacc ggttgaccag cctcagccac cggcagtgcg
     9121 ggttcgtctc aatgcggggg gacggcggca ggagcctgcg gtacgtcgac gtcgccgagg
     9181 gtgtgcacct gcgcctcgat gaggacaccc tcgccgcccc tgacgcgctc gcccgcacgg
     9241 tcggcgacct gctcagccag ccccgcgagg tggcatgggc cggggtaagc cttccgcccc
     9301 gcaccatgtt gtccaacctg gacctgtggc tggccactcg tttcgcgggg gaggccggcg
     9361 agttcatggt gctgacggcg caggaggagg ccgtcgagtc cggcatcgtc gcgccgtcgt
     9421 ggcggttcgg tgcccccgcc gccctggtcg agggcacgtt ctcctaccgg tcggcgctga
     9481 agtggaccga ccggaggttt gatctcggcg caaccgccca cggacccgcc gccgctgcgg
     9541 cggccgagcg gatagtcgag cacatgcgcg catggctgaa cgccgccagt ccgattccgg
     9601 ctctggaggt tctgcccgcg cgcactcccg acggcgacct gccggacggg accgtcctgg
     9661 acaagcgaca cagccgcatc gtcctttcct tccccaccgt catctcccag ccagaaggga
     9721 caaactcctg atggagcacg acgagcagta cgacttgaac atccgtctgg tcgactccgg
     9781 ggacgtcgcc agcggtcacg ccaccagcac cgacgacaac tgcggctcgg gcaacaccga
     9841 ctcggacgcc tgtaccacca acgccgacgc tggcgtgcgc taaccacccc gcaacgcctc
     9901 ttgccgggcc tggtcccgcg cgcggctccg tccgcaacag ggccgggccc ggcccgcgtt
     9961 gaacgccccc tctgccgacc gccaggacgg tgagcgaccc atgttccacg cgacgagcgc
    10021 ggcactgatc agagcggccg cctatcccga tgatctggtc ctgcccgcct ggcccgacct
    10081 ggccgccgac cagcctggac cgtggcggga gtggctggag gaggcgtggg cgctgcccgg
    10141 gttcgcgccc gctgtcacct cggccgcgcc cgacctcgcc gcccagatcg ggcgcgtact
    10201 ggacggacag gccatgcaga cgcgccgatt acggcgcctg gtggaggcca cgatccgata
    10261 cctactgagg tggacgaccc gcgcgactcc cttcggccgc ttcgccggtg tggcgccggt
    10321 cgagctcggc ccgcgcgcgg cggtgcactg gagcgggcga caccgtgccg cagcccgtcc
    10381 cgacgaccgt ttcattgcgg agcagaccgc gcgggccgag cgggagctgc cggtcctgcg
    10441 tgcggtcgcg gtgatgacca accctcttgg atacgcccgt ggcggacgtt gggtgctgcc
    10501 atgcgcacgc accgagcagg accggatgtg ggacgtggag atcgagctga ccgaaccggt
    10561 gcgggctgcg gtcgagcggg ccgtctccgc cgtcgcgttc actgatcttg ccgttacggt
    10621 ggccgacaag cttcccgatg gtatggccga ggccgaacga ttgctggccg cgctggtgaa
    10681 cgccggggtg ctggtgtcgg cgatacgacc gccgatgacc gtgaccgacc cgtccgcgca
    10741 cctgacccgc cacctcgccg accacgctgc cggacgcctc gacctgcccg accccggcga
    10801 ccagatcgcc gtcgacctgc gggtcggctg ctcggtgacc ctgccaccag cagtggtcgc
    10861 cgccgctgaa gacgcggcta gcacgctcac cgccgtggcg ccgcggctgc ccggctggac
    10921 cgtctaccat cgcgcgttca tcgaacggtg ggggccaggc gccgccgtcc cgctacgcga
    10981 ggtggtgaac gtcctaggat ttcccgccgg ctaccgaagc tcggcccgtc gcgacccggc
    11041 ggccttcacc gcccgcgacg cgctgctcgc cgacctggcc cagcagtcgg ccttggacgg
    11101 ctgcgccgac gtcctgctcg atgacgacct gatcgccgcg ctgcgcggcg aggatccgcg
    11161 gccaccgatc ccgcacaccg aactccggtt caccctcacc gccccgacac cacggcacct
    11221 ggatcggggc gcgttcaccc tgaccgtggt gagcggcgcc cgccacgccg gcgtcgcggc
    11281 cgcccggttc ctgtacctgc tcacccccga cgagctggag cgcttccgca gcgtctacac
    11341 ctgtcttccg gccgcgatgc ccggcgccga catcgtgcag ctctcggcgc ctccactcga
    11401 cgcgggcctg gcgaccctcg cccgcacacc ccaggtgctg cccgtgctgc cggtcgggga
    11461 cttccacccc gccccgtcct ggacgctggc ggacctggcg gtggcgggag acggcgagcg
    11521 gctgtggctg gtctcggcga ccaccgggcg gccggtcgag ccgctgctgt tcaactgcgt
    11581 gatgctgccg accgcccagc aaccactcgt gcggttcctg accgagatct ggacagcgtg
    11641 gaccgcgccg tgcgcccggt tcgattgggg gcacgccacc ggtttgccgt tcctgcccag
    11701 ggtccggcgt ggccgcgccg tcctgcaccc ggctcgctgg agcgtccgcg cggccgcgct
    11761 gcccggccgc accacctcgt ggccgcagtg gcgagacgcc tggcagcgat accgcgaacg
    11821 gcaccggctg ccgcaccagg tcttgatcag cgcagggcgc ggcgtcgatg acgtgcggtt
    11881 gcgcctggac ctggacgaga ccgcccacct agtgctgctg cgcagccacc tgcaccggca
    11941 cgacgccgcc gtcctcaccg aggccgacgg gccgtcgggc tggatcggcg gcagaccggc
    12001 cgaactcctg ctcaccctca cctccacccc accacacccc cgtcgcccac cccggccttc
    12061 ccgccccacc ggcatccttc agcacctgcc cggacggtca cgatggctgg acgcccgcgt
    12121 ttttggccga tcccagacca cgatcaccga catcctcacc cgcctccccg aactccccgc
    12181 gggctggtgg ttcctgcgct accccgaccc caccccccac ctgcggctac gaataccgct
    12241 gcgcgacagg aaccacttcg cggccatcac ccacgacctc gcccagtggg ccgagcagct
    12301 gcacaacaac ggattggtga acgactatgc cctggcgacc taccgacctg aaacccgcca
    12361 cggaagcggc ccggccctgg ccgcggccga agcggtcttc gccgccgact cccgcgccgt
    12421 cctcgggcgg ctgtcgggcg agttggaggc cgccgcagcc gccgggatga tcaccatcgc
    12481 gcacgggttc accggcggcg acggcctgcg gtggctcgtc gaccacgtgc cgcaccgcag
    12541 cggaccacgc ctggaacccg cccaactcgc ccgcgcccgc cacccacacc acggcccaga
    12601 ccacgagctg gcgacggagt tggctacggc cctggccacc taccgagcca tcgccgcccg
    12661 ggacgggctg gacaccgacc aggtattggc cgacctgctg cacctgcacc acgcccgcat
    12721 gatcggcgtc gacaccgcat ccgagcgaca ctgcctgcga ctcgcccgca ccatcgccca
    12781 cacccacctc cacaccaacc gcaacagcta catgcgcacc aaccttcatg accaagacac
    12841 tcgtggccgc gaccccatca gcaggacgtc atgagcacgg ggcaaaacct cgccgacggc
    12901 gccgccggaa tcgccctcct ccacctggaa accggcgact gggaagccgc gtacacggcg
    12961 ctacgggagg ccgtcgccga cggcgtcagc atcgccggcg gggccagcct ctactacggc
    13021 gctcccgctc tggcgttcgt cctcgccgcc tccgaccggg cggaccttac ccgcgccaaa
    13081 gccgtcgccg ccgcagggac cgcgacggtg acgcgccgtc gcctggaggc cgcccaccgg
    13141 cgcatcgacc aacgccagcg tccgccctac gccgaattcg acctcatcgg cgggctcacc
    13201 ggcctcggcg tcgccctacg ccgcatcggc gacctcgacc tgctccgcga cgtcctgacc
    13261 tacctggtcc gcctcaccga gccactcgac ggactccccg gctggtggtg ccccaccggc
    13321 ccccaccgca ccaaacccgg cccgcccgga ggccacagca accacggaat ggcacacggc
    13381 atcaccggac cactcgccct aatggcgctg accctacgcg acggcatgca cgtccccgga
    13441 caaccagcgg caatcgcccg catctgcacg tggctcgacc aatgggaaca gcaaaccgat
    13501 gacggctccg catggtggcc gcagaccatc accctagaag aactacacta cggcgacacc
    13561 gatcagccgg gcccgttgcg gccgtcgtgg tgctacggga ctccgggcat cgcccgcgcc
    13621 cagcaactcg ccggccacgc cctcagcgac accgcacgcc agagaaaagc cgaaaaggcc
    13681 ttcaccgcat gcgtgagcga ccacgaacaa ctggtcctcc tcacctgccg cagcctctgc
    13741 cacggaacca gcggcctcct agccgccgga cgacgaatcg ccgccgacgc ccatgccccc
    13801 atctctgccc cactgccgct ggacctgcac ccaaaacccg ccccacccgg cgagccaccc
    13861 ggcttcctca acgggacggc cggagcagaa ctgaccacca ccggaaccgt cacctcctgg
    13921 gacgcctgcc tcctcctgtg ctgacgaaag acaccacatc atggacgaac ccccctgcga
    13981 gacttcctcc tggacgcagg tgaacatcgc cttccccggc cacaacgccc gtgagcgcga
    14041 acgacgagcc gccgcccatc tcgtgcggat tctccccgca gccgaggccg acggccgcat
    14101 cacctcatgg ttcttcaccc gcaagacccg ctggcgcatc cgctaccgcc ccgcaaaagc
    14161 cagcgacagc cgccccctcc gttccctcct cacccaaggc gtcgactcga ccaacgacat
    14221 ctacgagccc gaagtccacg ccttcggcgg ccaccccagc atggaaaccg cgcaccagct
    14281 gttccacgcc gacagccacc acctgctcac cttcctcaac ggcgctccca ccgaccgcag
    14341 agaacgatca ctgatcctgc tcaccacact catgcgagcc gcaggcctgg agttcggcga
    14401 gcaaggcgac gtatgggccc gcgtcgccga acaacgctcc cccctacgca gcgacctccc
    14461 cgaacccgca acatgggcct ccttcaccca cggcgtccga cacctcctcc tcggcaagcc
    14521 ccgacccgac gacatcggca gccactggct caccgcgttc gagacagccg gggggcaact
    14581 caaagacctg cgcgagaggg gccagctcac gcgagggata cgcgcgatca ccgccctcca
    14641 tgtgatcttc cactggaacc gaatcggtct caccggcccc acgcaggcag aactcgcgca
    14701 agccgtgaag gaagcgattc ttgctcccta ctgaacagga cctcgatcac gcttctcgca
    14761 ggatgctcgc agccagttgg tagtcgatgg gcgccgctac tcttcccgtc cggctccgca
    14821 cgatcgcgtc ccggccaggg agccccggtg cggcgaacgg caggggggca gcatccgtct
    14881 ggtgctcgcc caatcacgcg cccgatgacg gtccccgctc tcgccacgtc ggatcgtcgc
    14941 ggacgtccac gccgccgtgg gacgcggcaa catcgccctc gccgacacgg gggcggtgaa
    15001 gatccggatc gcgcgcatgt atccgaccta ggagccgaac acgatagatc caaggctgac
    15061 tggtcagtca gcgctctccg ccttgccaca tggccagccc aagggtaacg gacctgccag
    15121 aaggcagccg gggcccggtg agcctcctac ctagtccacc aacaggccga ccttacgaca
    15181 gccatgtccc gcaaatgagg ccgaatgtct gaacgtgtca gtgtctccgg gtacaaagga
    15241 tgctgtgact tccagcaacg gccccctcga ggacgagacc tgcaagcgct tcgtcctacc
    15301 cgccctcgat cgggctggct ggggcgagga ccagatcaag gcccagtacc gaatcaaccg
    15361 gggacggatc cagcccacag cacgccgcca ccgccaggaa cgtcccctag tcgccgacta
    15421 tctgctggag tactcggacg gtctgccgct ggctgtggtg gaggccaagc gctcccgccg
    15481 agaccctgcc gctggcttcg aacaggtgaa gcgctacgcc gccctgctgg acgtgccgtt
    15541 cgcctacacc accaacggga cgaagaccct cgagatcgac tcctgcaccg gcctcactac
    15601 cgagatcacc gagttccccg cgcctgagga tctctggacg cgctactgcg ccactcgagg
    15661 tctcaatgag gacttccaaa ccgcgctagc atccgccccg ttcaaccaca atgtccgaaa
    15721 ctgggacaac acccccaagg aaccacggta ctaccaacgc aatgcgatta atcgggcggt
    15781 gcaggcgatc gctcaaggcg agaggcgtgt gctgctggtt ctggccacgg gaaccggcaa
    15841 gaccctagtc gcttcccaga tcgtcgcgaa actgtggaac gcgagctggc caggcgaccg
    15901 ccgtcctcgg gtcctttacc tcgctgaccg taatatcctc gtcgaccaac ccaaagacga
    15961 ctacttcgaa cgaatgttcg gcgaagctgt tcacaagctc acccgcggcg tcgcgttgac
    16021 gagtcggaac atctacttcg ccctctatca gtcgctcaca cgtggcggcg atgcagaaga
    16081 tctctaccag cagttcgacc gagacttctt cgacgtgatc gtcgttgacg aatgccatcg
    16141 cggtagtgca accgagggtt cccaatggcg cgaggtgctt gaccacttcc attcggccat
    16201 ccaactcggc ctgacggcaa cgccgatcag caagcgcgac gccgacacct acggatactt
    16261 cggcgacccg atctacgaat acactctggc tcagggtatt caggacggct ttcttgcccc
    16321 ctaccgggtc cgcaatgttc gccttgacct cgacctgttc ggctggcgac caagcgaagg
    16381 acagctcgac atgtacggcc gtgagatccc ggacgagctg tatgggccga gggagttcga
    16441 gcgaatcgta gcagtcctcg accgaaccga cgccgcagca cgatatctga cggagtacct
    16501 gcataagacc aaccgtatgg ccaagacgat cgtcttctgt cagacgaaag accacgccct
    16561 ccgcatggtg caagcgctgc acaatgccaa cgccgatctc gttcggcagt acggcaactc
    16621 ctacgtctgc cggatcacct ccgacgacgg cgacgctggc cgcgagcgtc tcggggagtt
    16681 ccgcgacgat agcacccaga tcccgacgat cgcggtaact gccaggctct tgtcgacggg
    16741 tgttgacatt cccaccgttc gcaacattgt catcttccga gtaatccggt ctatgccgga
    16801 gttcaagcag accatcggcc gcggcacccg cctgtcccct gagacagaca agtacgcctt
    16861 cgacatcatc gatttcgtag aagctactcg cctcttctat gatcctgact tcgatgggcc
    16921 gccgatccgc aggctgcgcg acgagaccga cgacgagggc aatatcgtca ccacaatcgc
    16981 cgaagacctg actgacccag accctgaccc ggattccgac gcagcggccg aacctgagcc
    17041 tgagtacgag gaacaggaca ggggaggtct gccaccgaca atcgtcaccg accctgatga
    17101 aattgacgat atccgcgcac aaggcagcac ctactacgtc gacgacgtac cggtcactgt
    17161 ctttggaacg gccatgtacg tcacggagac tgacggctcc gggacgcgac tgcgtctggt
    17221 gagcatcgag caatatatcc gaggtcgtct ccgcgaactc gacctatcac cgcaccaact
    17281 gctcacccaa tgggcccaaa ctgagagccg caaggaactc cgagatagac tggacgagtt
    17341 cgggatcacc ccggcggatc tcggcgaact gacgggtcgc ccggacgctg acacgatcga
    17401 tctgcttatc tacattggtt gggacctgcc cgtactgtcc cgctcagagc gggcactccg
    17461 attcaaactt cgccatcgca acttcctcga gtcttttgca gacgatgccc gcgaggtcct
    17521 ggaccgcgtt ctcgagcagt actcgactcg aggcgcggag gagttggacg ttcaggcgct
    17581 gaggtcaccg gcatacgccg acctcggcac agtcgttgag ctagcttccc gattcggtgg
    17641 cggcgcaggc ctacggagcg ccatcgacgc tctcggcgtt cagttgtatg aggcgtccta
    17701 ggaataattt gcttatcttg tagcccaatg caggcatccc acacaaaacc caacgcgact
    17761 attggttcga catgcgctat ccttggccca tgcagcagcg agaagagggc cctcgagccc
    17821 aactgtggcg ccgagccgcg caacagtgtg gctactgcac cactgcgcag gccctgatgg
    17881 gcggctactc ctaccagtcg cactacttcc gtgtccggct cggcggcagg acacgatcgc
    17941 ccgcagcgtc tatcaatttt acgaatttgc caacgttgca actcacgata gctaccaaag
    18001 cgatactgtc ccgccaccaa cagggggcga attttttcac cgccacagga gccgctatct
    18061 gtcaaacaga gctgtcactg gaacgcgcct ctaacgaaac ggatctttga taatcatggc
    18121 cccatccgcg aagaaggaca caacatcccg tgcccggctg tcagccgtca tcaagtctgc
    18181 gcgcgacatc atgcgcaaag atgcgggcct caacggcgac ttggaccgcc tgcctctgtt
    18241 gtcgtggctg ctgttcctgc gcgccttcga cgcccttgag gccgagcgag aagtcactgg
    18301 cgaagagtca atcatcaagc cggactacca gtggcgcgcg tgggcggacg atgagacctt
    18361 cactggcgaa gatctcttgt cgtttatcaa caatgagctc attccttatc tcaggggcct
    18421 gagtagcgac gagcccggcg accctcgaaa cgtcctgagc caggtcttcg gcggcgtcca
    18481 gaaccgcatg ctttcgggct acctattccg tgatctggtc aaccagatcc gcaagattga
    18541 cttcaacagc agtgacgaca tccatacgat ggcgttcctg tacgagtcgc tactaaagga
    18601 gatgcgcgat gccgccggcg actcagggga attctacaca ccacgtccag tcatccggtt
    18661 catggtcgag caaacattcc ccaagctggg tgagtctatt ttggacccag cttgcgggac
    18721 tggtggtttt cttgtcgagg cttacaccga actggctcct caagccactg gtcgcatgct
    18781 ccagcaacag ttggtttaca acctgcgcgg cattgagaag aaaccacttc cctacttgct
    18841 gtgcatgatg aacctcaccc tacatggaat ctcggccccc aatattctga atgcaaacgc
    18901 cctacgaaaa atgatcgccg acacgagccc gagtactcaa gtcgatatta tcctcaccaa
    18961 cccacctttc ggcggcgagg aagaggattc catcgccaag agctttccca gtggctacca
    19021 gacccgcgaa acagcctggt tgtttcttca cgcggttatc cgcaagctta agcccggcgg
    19081 gcgctgcgcc attgtcctcc ccaacggtgc tctcttcggc gaaggaatcg ggacgaagat
    19141 tagaaagaag cttctacaag aatgcaattt gcatacaatt gtgcggcttc ctcagtccgt
    19201 cttcgctccg tacaccgaca ttccctccaa tctccttttc tttgagaaga ccggcccgac
    19261 gaaggaaatc tggttctacc agatcgaccc acccgaagga cgcaaaggct attccaagac
    19321 caaaccaatg agatacgaag agtacgctgc atgcgctgaa tggtggggag gggaggaacg
    19381 caaggagcga cgggaaaatg atcacgcgtg gcgagtgcta atcagtgaga tcgccgaaag
    19441 tggttatgac ctcaacatcc ttaagccaac agtcgaggct agcttgcccc atcatccacc
    19501 agtcgacatc cttaaggaaa ttataagcac cgaaaattct attacggcga cactgatctc
    19561 cctcttggaa gaattggata gcgaagcatg aaacttccgg aaaggccttt gggggatgcc
    19621 attaggctga atctaatgcc agtcgacgta tctgcaggca ccaactaccc gatcgctggg
    19681 ttgtacagct ttgggagagg cttcattcgt cgccctacca ttgatggatc agaaacagcc
    19741 tactcccgtc ttttcaggat aagcaaggac cagcttgtaa tgagtaagtt gggagcctgg
    19801 gaaggtgcct tcgctgtcgt cccagatgaa ttcgatggag cgttcgtctc tccagagtac
    19861 ccaagctttg acatcgacag ttcagtcgcc accacagctt atatagccca tctcgtcagg
    19921 tggccggcat tttgggagcg agtgaatcct cgcggttcca tggcgcgcag aaaacgtatc
    19981 acccctgcga gactggcaga aatcgctgtc ccgctacctg atctggaaga gcagcgacgt
    20041 atcgcttccc gcctcgacgc tgccgaggaa cgacttaaag aagtgggtag gcaacgggac
    20101 tactccatca agcttcatga ttctctgagg gaatcaatgt tttctaacga acaactcggc
    20161 gagcctgcga gacttggaga cgtactcaca ctcgaaagaa ttcctgcgat tatcgaccca
    20221 gaggaaaatt atactcagat cggcattcgg tcctttggca agggcatctt tcacagagat
    20281 ggctctctag ggtccgagct gagcaaattg aagtattatg agatccgccc cggaaatctg
    20341 attgtaagca acattatggc atgggagggc gcaattgcag tctcgtctga agccgacaac
    20401 ggctgcattg gctcccaccg gttcctcagt ttcaaaccaa cagagagtgt ggatattcgc
    20461 tacctcagcc atttcttcca gtccaggcaa ggacgggagc tgataaagac aacgtcaacc
    20521 ggaaccgtgc tacgcaacca gacactttcg atcaaacact ttgagaacct aaaagtgccg
    20581 cttccgccta tcggcgagca gaagagagtg gcatcaattc tcgaacgaag caatgtcatc
    20641 caaggcaggg tggcgacgca aggagagctt tcaaacacgc ttaccaggtc cctcctgcac
    20701 gcggcattca gcggaaaact ctagttttgc caaggctctc gcctacctca cgagggggaa
    20761 tcagagtgcg gtcggacacc tcgtcccgtc agtgggacgc tctctagggg cagacccgca
    20821 gcgtcaaaga gcactacgcc tgctcgttcg tgacgcaggc tgcccagcaa cggcgcagca
    20881 gcaaaggcaa tgtccgccga gatagttgcc ctgccttttg tgtttccggg cgggccactg
    20941 gcgctgcgaa ctgcttcgga ggccgcagcg acccgagctg cccccgttat cttctccacg
    21001 tacccggtga tcagggatct tggtcgccag gccgggcatg actgattgcc cctgtcgttg
    21061 atgatcccgg cgggggtgtt gtcaccgggt ctggtggcgt cgatgaaccg ctggtaggga
    21121 ccggccgccc cgatcgttgt gggcaagtct cgtcataacg tagctgccgg gcatcatcgc
    21181 ctgaccgcgg ccaggcatgc aggattggtt ggacgggagt gtcttgcagc aagtacgcgg
    21241 tgttcctcgg gttggacgtc gacaagagcg ggcatcacgc gggcgcgctg gacccctctg
    21301 gcaaacgtct gcacgacagg gcgctgccca actggctatg taaggtctca tgactttgtt
    21361 gacagaccgt tctctgtaga tgcctgacag cgctccccaa tgagtgcttg tctttcctgg
    21421 ttcgtctcgt gagggtgggg ggcatggggt ggcggatcgt tcgtggatga cggagaaccg
    21481 ataccgggcg gtgctggagg ttctgattgg tggcccggtc accgaggtcg cgcggcggta
    21541 cggggtgcct cgccaaacga tctacgtatg gtgtaggcgc tatcggcagg acggcgtcga
    21601 ggggctccag gggaagtccc gccgccccgc tccagcccga ctcgcctggc cgccgacgtc
    21661 gaggcgctga tctgcgagaa gaaggagccg ccaggcgggg tggacatcga accggccgac
    21721 cacgtcctcg ccgctcccgc ggcggcctga ccagcaagtt tcatctggcc tgcgaacacc
    21781 gacagcgcct gttgtccctg gtcctccccg ctgggcagcg cggcgacagt ccacagttcg
    21841 tgcccgtgtc ggcggcggtt ctggtgccca gcctgggtgc cggcctccag ggtctcggcc
    21901 tcggtgcgac cgccgacgta gagtccgggc tggtcctcat agagcgcgat cgggccgttg
    21961 accgtcagat tgccggtgat cacgatcaga tcgacatcgt cctcgtcgtc ctcgcttcgc
    22021 agggcattga cggcgtccag gaagtccccg tcgaccgcga gatcgccgtc gaagaacagc
    22081 acgctgtcat agtcggacga ctctccttcg ctctcgaacg cggcggacaa cgcgccgctc
    22141 agacgggcgt cggcgtcggc ataggacagg gatgcggggg tgggggatag cgacatggcg
    22201 acgagcatag gtccgcgctg tgacagccct acgggaaagt ccagcgccgt cgtgaggcgg
    22261 ctggctgccc cgccgtcgac atcagtagca gaagttgaac acagccccac tgttcattgg
    22321 tgagatcccc acgcgcctca tcggtgagat ccccgcgcgc cacaccagga tcatcccggc
    22381 gtggcgcgat caacgcgaca gcgttctgaa acacgcccta aagcctgttg cagaaggctg
    22441 tgatctggga actttctgtg tatgggtggg gtgttgcgag ccgagccgtt gtgggttgag
    22501 gtgttcaccg ggctgcggat gacacagttc cagcggctgg tgcgggcggt gcgcgagcgt
    22561 ggcggcaacg gtccgcagaa gggtccacgg atcgggcggc cgtggtgcct gccgctggcc
    22621 gaccgggtac tgctggtggc gatgtactac cgcaccaacc tgaccatgcg gcaactggca
    22681 ccgctgtttg ggacctcgcc ggccacggtg tgccgggtgg tgcagcggct gggcccactg
    22741 ctggccctgg agccggcacc gcgccccgcc gagccgctgg aacggctgtg gatcgtggac
    22801 ggtaccttga tcccggtctg cgaccggcgg gtgggatcct ccagccgcaa ctaccggttc
    22861 tcggcgaacg tgcaggtcgt ggtggacgct gacactcggc tggtgctggc cgcagcccgc
    22921 ccggtgccgg gcaccaccgc cgacgcccag gcctggcgtc gctcgcacct gcccgagtac
    22981 tgccgcggtg tcaccgtgct gggcgatggt gcctacaccg gctgtggact ggtgatccca
    23041 caccgcaaac gccccggacg gccgctgctg ccggtccagg aggccgacaa cgccgagcac
    23101 cgcaaggtcc gtgcccgcgt cgagcacacc ttcgcccgca tgaagaacta caagatcctg
    23161 cgcgattgcc ggcaacgcgg tgacgatctg cccaacgccg tccaggccgt cgctcacatg
    23221 cacaacctcg cccacacacc cgccccagca gcgtgatcga ctaccgacgc ccaacagctc
    23281 gaacacgcct actcacagcc ttctgcaaca ggctttaggt cttccctgtc cccgaacgcg
    23341 ttctcgggca cagctcgacc acccggccgt cccggagatc ctggccaggt tcgacggggc
    23401 gcccggcctg cgtgctgccg ggcagcgcgg cctgctcaac ctcgtccgca agctcgcccc
    23461 gtgcatgggc gagcagctcg tcaccgacag catcactgct ctggacgctc agacggtgac
    23521 cgtcccggac taaacgccag ccgaggccgt gctgccccgt ctggccgtcc cgctgcgcaa
    23581 cgtcctcgat caacgcaagc agaccgccgc ggaggtcgaa atcatgctta atgcgcaccc
    23641 tctcgccaag gccctgacct caatgccggg cttcggggtc aggaccgcct ccctagtgcg
    23701 gctcgaggtc gggtacggct cggccttccc cacgcccggc catctggccg cctacgcagg
    23761 tctcgccccg gtaaccaagc agtccggcac ctcgatcaag gacaacgccc gcccaaaggc
    23821 agcaacaagt acctcaagca cgccatgttc ttggccgcct tcgcctccct cgctgacctc
    23881 gtcagcaggg cctactaccg caagaagaga gaacagggca aacgtcacaa cgccgccctg
    23941 atctgcctgg cccaacgacg cagcgacgac ctgttcgcca tgctccgcga cggcggaatc
    24001 acgccgcgca tcgcccgccc cggcatcgag tccgcagaac gcctgggccg ccaccgctgg
    24061 atgatcgaac ggacgctggc ctggctgctg ggctatcggc gtctgaccat ccgctacgag
    24121 cgccacggcc acctgttcaa cgccttcctc gtcctctcag ccaccatcac ctgctacaag
    24181 aaactcaccc gcgacccaca tgagacgccc tcttagagcg tgtcctatgt ggtgaggcgg
    24241 tcgttgggtt tgatatgggt caaggtaggt ggagttggat cgtgccggac ggattatggg
    24301 agatcgccaa gccgttgatc ccgccgtcgc gggtgcgccc gcagggcggg ggaacgcagg
    24361 acacccctga tgagacggtg ttcgcggcga tcatctatgt gctggtgagt ggttgtgcgt
    24421 ggcgggcgtt gccgccgtgt ttcgggatgt cgaagcgacg gctcaccgcc ggtttgtaat
    24481 ctggtcgcgg gcgagggtgt ggggccggtt gcaagaggcg gtgctgcatc ggctggatga
    24541 tggcgggctt gatcgacgtc tcgcgtgtgg tgctcgattc ggcccatgtg agagcgaaaa
    24601 agggggcgaa cacacaggtc cgagccccgt ggaccggggt aggccgggtt ccacaatgca
    24661 tgtgctgtcg gatgcgaacg gactgcccct ggtcgtcggc gtctcggccg gcaacgtcca
    24721 cgacagccag ggtc
//
