GCF_009728995.1 - 13 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_VTZW01000009.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	T2PKS	300,595	373,095	High	persiamycin A	PKS:Type II

NZ_VTZW01000004.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	terpene	200,285	220,566	High	isorenieratene	terpene

NZ_VTZW01000020.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	ectoine	90,810	101,226	High	ectoine	other:other

NZ_VTZW01000018.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	terpene	1	20,256	High	geosmin	terpene:Sesquiterpene

NZ_VTZW01000003.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	T1PKS	473,467	516,481	Low	arginomycin	other:other

NZ_VTZW01000016.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	RiPP-like	160,537	171,967
Region 17.2	phosphonate	514,765	560,726

NZ_VTZW01000008.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	terpene-precursor	207,290	228,360
Region 19.2	betalactone	408,465	436,078

NZ_VTZW01000019.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 20.1	NRP-metallophore,NRPS	142,181	208,569	Medium	Fuscachelin A/Fuscachelin B/Fuscachelin C	NRPS:Type I
Region 20.2	terpene-precursor	331,179	352,219
Region 20.3	T1PKS	371,713	435,261

NZ_VTZW01000015.1 (Streptomonospora sp. PA3)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	lanthipeptide-class-ii	179,183	205,443

No secondary metabolite regions were found in these records:: NZ_VTZW01000001.1 (Streptomonospora sp. PA3); NZ_VTZW01000006.1 (Streptomonospora sp. PA3); NZ_VTZW01000022.1 (Streptomonospora sp. PA3); NZ_VTZW01000002.1 (Streptomonospora sp. PA3); NZ_VTZW01000011.1 (Streptomonospora sp. PA3); NZ_VTZW01000017.1 (Streptomonospora sp. PA3); NZ_VTZW01000021.1 (Streptomonospora sp. PA3); NZ_VTZW01000005.1 (Streptomonospora sp. PA3); NZ_VTZW01000012.1 (Streptomonospora sp. PA3); NZ_VTZW01000014.1 (Streptomonospora sp. PA3); NZ_VTZW01000013.1 (Streptomonospora sp. PA3); NZ_VTZW01000010.1 (Streptomonospora sp. PA3); NZ_VTZW01000007.1 (Streptomonospora sp. PA3); NZ_VTZW01000023.1 (Streptomonospora sp. PA3)

Compact view

NZ_VTZW01000009.1 - Region 1 - T2PKS

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Location: 300,595 - 373,095 nt. (total: 72,501 nt) Show pHMM detection rules used

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

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SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

FZ103_RS09715: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

FZ103_RS09720: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

FZ103_RS09765: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

FZ103_RS09900: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

FZ103_RS26015: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase carboxylase glycosyltransferase halogenase methyltransferase transferase

FZ103_RS09795: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

FZ103_RS09825: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

FZ103_RS09830: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

FZ103_RS09835: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

FZ103_RS09860: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

FZ103_RS09885: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

FZ103_RS09905: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Hydrolases: deacetylase hydrolase

FZ103_RS09920: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

FZ103_RS09960: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

FZ103_RS09990: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: cyclase dehydratase

FZ103_RS09810: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

FZ103_RS09855: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

FZ103_RS09870: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

FZ103_RS09840: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

FZ103_RS09845: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002045.3	1.00	PKS	persiamycin A	Streptomonospora sp. PA3
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.76	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000231.5	0.62	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0000234.5	0.61	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.59	PKS	oviedomycin	Streptomyces antibioticus
BGC0000271.5	0.57	PKS	spore pigment	Streptomyces avermitilis
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001817.5	0.56	other (other)	vancosamine	Streptomyces sp. WAC2288

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002045.3	1.00	PKS	persiamycin A	Streptomonospora sp. PA3
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.76	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000231.5	0.62	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0000234.5	0.61	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.59	PKS	oviedomycin	Streptomyces antibioticus
BGC0000271.5	0.57	PKS	spore pigment	Streptomyces avermitilis
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001817.5	0.56	other (other)	vancosamine	Streptomyces sp. WAC2288

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.08 out of 18.57

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 25.56 out of 30.11

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 25.56 out of 30.11

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.17 out of 25.31

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 25.55 out of 30.11

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.02 out of 20.01

Confidence: medium

Additional weak hits (25):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.25 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.56 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.80 out of 27.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.33 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.36 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.12 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.17 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.27 out of 39.62

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.52 out of 29.25

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.98 out of 27.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.07 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.00 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.26 out of 35.63

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.23 out of 27.55

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.62 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.54 out of 20.01

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.27 out of 20.01

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.91 out of 35.63

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.45 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.33 out of 28.14

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.02 out of 18.57

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.92 out of 28.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

TFBS Finder

Type II PKS gene cluster prediction details

Cluster section:: 300594 to 373095
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 664.8; E-value: 9.1e-203)
Product class(es):: tetracenomycin
Product molecular weight(s):: acetyl-CoA_8: 570 Da
acetyl-CoA_9: 612 Da

FZ103_RS09715: KR (Score: 62.4; E-value: 1.2e-19)
FZ103_RS09720: KR (Score: 79.0; E-value: 1e-24)
FZ103_RS09765: KR (Score: 132.8; E-value: 4e-41)
FZ103_RS09795: MET C10 (Score: 439.6; E-value: 1.5e-134)
FZ103_RS09830: GT (Score: 344.4; E-value: 2.6e-105)
FZ103_RS09840: CLF 8|9 (Score: 664.8; E-value: 9.1e-203)
FZ103_RS09845: KS (Score: 768.9; E-value: 2.7e-234)
FZ103_RS09855: CYC C4-C21/C2-C23|C2-C19 (Score: 110.8; E-value: 6.9e-35)
FZ103_RS09870: CYC C9-C14 (Score: 252.3; E-value: 3e-78)
FZ103_RS09880: ACP (Score: 105.7; E-value: 2.1e-33)
FZ103_RS09900: KR (Score: 155.0; E-value: 6.9e-48)
FZ103_RS09905: HAL (Score: 401.9; E-value: 7.9e-123)

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CatR	H2O2-responsive repressor
CelR	Cellobiose uptake repressor
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_VTZW01000004.1 - Region 1 - terpene

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Location: 200,285 - 220,566 nt. (total: 20,282 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase synthase

FZ103_RS03690: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

FZ103_RS03735: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

FZ103_RS03750: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: methyltransferase

FZ103_RS03755: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: synthase

FZ103_RS03690: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Ligases: synthetase

FZ103_RS03730: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.74	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.68	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.65	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.63	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.63	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000645.3	0.53	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000648.3	0.53	terpene	carotenoid	Myxococcus xanthus
BGC0000640.3	0.50	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000641.3	0.49	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.49	terpene	carotenoid	Enterobacteriaceae bacterium DC260

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.74	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.68	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.65	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.63	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.63	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000645.3	0.53	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000648.3	0.53	terpene	carotenoid	Myxococcus xanthus
BGC0000640.3	0.50	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000641.3	0.49	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.49	terpene	carotenoid	Enterobacteriaceae bacterium DC260

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

FZ103_RS03730: PT_FPPS_like

Domain 1 (65 - 380): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

FZ103_RS03740: PT_phytoene_like

Domain 1 (17 - 314): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → squalene; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

FZ103_RS03760: Lycopene_cycl

Domain 1 (5 - 380): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.09 out of 20.47

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.87 out of 29.72

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.07 out of 26.85

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.99 out of 20.97

Confidence: medium

Additional weak hits (9):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.09 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.23 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.38 out of 20.97

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 15.75 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.84 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.84 out of 29.38

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.50 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.13 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
NtrC	Nitrogen regulatory protein C
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_VTZW01000020.1 - Region 1 - ectoine

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Location: 90,810 - 101,226 nt. (total: 10,417 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

FZ103_RS22810: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.82	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.81	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.60	other (other)	ectoine	Methylarcula marina
BGC0000859.3	0.55	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.55	other (other)	ectoine	Methylomicrobium kenyense
BGC0000854.3	0.54	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000857.3	0.51	other (other)	ectoine	Methylophaga alcalica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.82	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.81	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.60	other (other)	ectoine	Methylarcula marina
BGC0000859.3	0.55	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.55	other (other)	ectoine	Methylomicrobium kenyense
BGC0000854.3	0.54	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000857.3	0.51	other (other)	ectoine	Methylophaga alcalica

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.86 out of 18.57

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 25.09 out of 30.12

Confidence: medium

Additional weak hits (6):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.82 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.07 out of 21.55

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.17 out of 32.74

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.46 out of 21.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.09 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
OsdR	Development and stress management regulator
ToxT	Regulator of MSHA biosynthesis

NZ_VTZW01000018.1 - Region 1 - terpene

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Location: 1 - 20,256 nt. (total: 20,256 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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other genes

resistance

TTA codons

binding site

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KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

FZ103_RS19215: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	terpene	Similarity score	Type	Compound(s)	Organism
BGC0001181.4		0.80	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3		0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0001181.4		0.80	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3		0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		germacradienol	C15	C1-C10	OH
sesquiterpene		geosmin	C12	C1-C10	OH

Genes with terpene domains:

FZ103_RS19215: T1TS + T1TS

Domain 1 (2 - 329): Type 1 terpene synthase

Subtype: Geosmin synthase, N terminal domain

Reactions:: FPP → germacradienol

Domain 2 (332 - 708): Type 1 terpene synthase

Subtype: Geosmin synthase, C terminal domain

Reactions:: germacradienol → geosmin

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.40 out of 26.85

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.90 out of 30.22

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description

NZ_VTZW01000003.1 - Region 1 - T1PKS

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Location: 473,467 - 516,481 nt. (total: 43,015 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FZ103_RS02470: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase

FZ103_RS25260: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

FZ103_RS02570: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: decarboxylase hydratase

FZ103_RS02485: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

FZ103_RS02540: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase synthase

FZ103_RS02475: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FZ103_RS02495: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FZ103_RS02550: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.60	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.60	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.60	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001268.4	0.58	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002154.2	0.56	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002192.3	0.56	PKS	FR901512	fungal sp. No.14919
BGC0000037.4	0.56	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001160.5	0.56	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.60	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.60	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.60	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001268.4	0.58	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002154.2	0.56	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002192.3	0.56	PKS	FR901512	fungal sp. No.14919
BGC0000037.4	0.56	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001160.5	0.56	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.84 out of 29.72

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.43 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

Additional weak hits (15):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.29 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.80 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.98 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.92 out of 29.38

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.38 out of 29.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.51 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.58 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.58 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.33 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.22 out of 36.54

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.52 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.35 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.54 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.19 out of 28.19

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

FZ103_RS02475: X

AMP-binding (13..423): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NGTLHANGWTYTCAVTAGATHVYGLTETTPFITV
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

FZ103_RS02495: X

AMP-binding (12..399): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NNSAHTAALNMLFGLCGGAVQGYGLTEAAPGALL
Nearest Stachelhaus code(s):: Val DALFLGGTFK (41% 8Å match)
Stachelhaus code match:: 60% (weak)

FZ103_RS25260: pk

PKS_AT (549..827): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 60.8
Methoxymalonyl-CoA: 57.2
Malonyl-CoA: 55.1
Ethylmalonyl-CoA: 34.1
Isobutyryl-CoA: 27.8
Propionyl-CoA: 22.3
Acetyl-CoA: 20.7
fatty_acid: 20.5
trans-1,2-CPDA: 20.3
CHC-CoA: 20.3
2-Methylbutyryl-CoA: 13.2
Benzoyl-CoA: 13.1
inactive: 10.3
3-Methylbutyryl-CoA: 9.9

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
NtrC	Nitrogen regulatory protein C

NZ_VTZW01000016.1 - Region 1 - RiPP-like

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Location: 160,537 - 171,967 nt. (total: 11,431 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

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other genes

resistance

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

FZ103_RS17235: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000468.5	0.31	ribosomal	bottromycin A2	Streptomyces bottropensis DSM40262
BGC0000470.6	0.31	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0001157.6	0.31	ribosomal	bottromycin A2	Streptomyces scabiei 87.22
BGC0000469.6	0.29	ribosomal	bottromycin A2	Streptomyces sp. BC16019
BGC0000193.3	0.26	PKS	aclacinomycin	Streptomyces galilaeus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000468.5	0.31	ribosomal	bottromycin A2	Streptomyces bottropensis DSM40262
BGC0000470.6	0.31	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0001157.6	0.31	ribosomal	bottromycin A2	Streptomyces scabiei 87.22
BGC0000469.6	0.29	ribosomal	bottromycin A2	Streptomyces sp. BC16019
BGC0000193.3	0.26	PKS	aclacinomycin	Streptomyces galilaeus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

Additional weak hits (9):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.94 out of 27.78

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.88 out of 25.75

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.52 out of 29.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.19 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.97 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.01 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.81 out of 39.62

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.46 out of 28.19

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.33 out of 27.18

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_VTZW01000016.1 - Region 2 - phosphonate

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Location: 514,765 - 560,726 nt. (total: 45,962 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

Legend:

core biosynthetic genes

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transport-related genes

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resistance

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase phosphate reductase

FZ103_RS18735: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

FZ103_RS18785: N-acetyl-gamma-glutamyl-phosphate reductase

smcogs: SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase

FZ103_RS18790: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

FZ103_RS18825: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

FZ103_RS18895: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

Transferases: acyltransferase aminotransferase halogenase

FZ103_RS18815: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

FZ103_RS18855: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

FZ103_RS18870: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

Hydrolases: hydrolase

FZ103_RS18800: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002608.2	0.77	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0001859.4	0.51	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000903.3	0.49	other (other)	fluorometabolite	Streptomyces cattleya
BGC0002036.4	0.48	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000897.5	0.47	other (other)	dehydrophos	Streptomyces luridus
BGC0000904.5	0.45	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000842.5	0.45	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000926.5	0.44	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.3	0.43	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002608.2	0.77	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0001859.4	0.51	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000903.3	0.49	other (other)	fluorometabolite	Streptomyces cattleya
BGC0002036.4	0.48	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000897.5	0.47	other (other)	dehydrophos	Streptomyces luridus
BGC0000904.5	0.45	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000842.5	0.45	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000926.5	0.44	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.3	0.43	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.63 out of 18.46

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 29.02 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 29.02 out of 30.11

Confidence: strong

Additional weak hits (9):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.65 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.62 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.65 out of 26.12

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.92 out of 36.54

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.72 out of 28.14

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.86 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.58 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CelR	Cellobiose uptake repressor
RpoN	Regulator of nitrogen assimilation and virulence

NZ_VTZW01000008.1 - Region 1 - terpene-precursor

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Location: 207,290 - 228,360 nt. (total: 21,071 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

FZ103_RS06880: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: carbamoyltransferase phosphorylase

FZ103_RS06830: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

FZ103_RS06870: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

Ligases: ligase synthase synthetase

FZ103_RS06820: carbamoyl phosphate synthase small subunit

smcogs: SMCOG1249: carbamoyl phosphate synthase small subunit

FZ103_RS06855: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

FZ103_RS06865: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002405.2	0.46	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0001521.3	0.44	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000677.5	0.43	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000649.3	0.42	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000922.5	0.42	PKS	2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one	Pseudomonas aeruginosa PAO1
BGC0000597.4	0.42	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000595.3	0.41	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0002343.3	0.41	other (other), ribosomal	ammosester A, ammosester B, ammosester C, ammosamaic acid cogener	Streptomyces uncialis
BGC0000664.5	0.41	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002405.2	0.46	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0001521.3	0.44	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000677.5	0.43	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000649.3	0.42	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000922.5	0.42	PKS	2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one	Pseudomonas aeruginosa PAO1
BGC0000597.4	0.42	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000595.3	0.41	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0002343.3	0.41	other (other), ribosomal	ammosester A, ammosester B, ammosester C, ammosamaic acid cogener	Streptomyces uncialis
BGC0000664.5	0.41	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

FZ103_RS06855: PT_FPPS_like

Domain 1 (49 - 345): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.67 out of 30.11

Confidence: medium

Additional weak hits (12):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.10 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.43 out of 31.73

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.56 out of 21.84

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.18 out of 21.55

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.34 out of 26.85

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.16 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.20 out of 30.11

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.91 out of 23.43

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor
VqsM	Regulator of quorum-sensing signalling systems

NZ_VTZW01000008.1 - Region 2 - betalactone

Download region GenBank file

Download region SVG

Location: 408,465 - 436,078 nt. (total: 27,614 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: phosphate reductase

FZ103_RS07715: N-acetyl-gamma-glutamyl-phosphate reductase

smcogs: SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase

Transferases: aminotransferase kinase

FZ103_RS07720: acetylglutamate kinase

smcogs: SMCOG1174: acetylglutamate kinase

FZ103_RS07740: aminotransferase

smcogs: SMCOG1019: aminotransferase

Ligases: ligase synthase

FZ103_RS07700: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

FZ103_RS07735: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0002584.2	0.42	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0001831.3	0.42	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000188.5	0.41	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0002110.3	0.40	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000895.5	0.40	other (other)	citrulline	Lactobacillus plantarum subsp. plantarum
BGC0000904.5	0.39	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000537.3	0.39	ribosomal	nisin U	Streptococcus uberis
BGC0000515.4	0.39	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0002584.2	0.42	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0001831.3	0.42	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000188.5	0.41	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0002110.3	0.40	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000895.5	0.40	other (other)	citrulline	Lactobacillus plantarum subsp. plantarum
BGC0000904.5	0.39	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000537.3	0.39	ribosomal	nisin U	Streptococcus uberis
BGC0000515.4	0.39	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.35 out of 26.85

Confidence: medium

Additional weak hits (5):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.67 out of 26.06

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.94 out of 27.55

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.84 out of 25.75

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.14 out of 30.22

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
RutR	Regulator of the pyrimidine and purine metabolism

NZ_VTZW01000019.1 - Region 1 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 142,181 - 208,569 nt. (total: 66,389 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

FZ103_RS20155: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

FZ103_RS20175: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase halogenase

FZ103_RS20145: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

FZ103_RS20270: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

FZ103_RS20160: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: hydratase

FZ103_RS20230: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase

FZ103_RS20170: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

FZ103_RS20135: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FZ103_RS20165: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002017.3	0.97	NRPS	potensibactin	Nocardiopsis potens DSM 45234
BGC0002341.2	0.95	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.92	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001833.4	0.89	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.87	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.85	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001128.4	0.84	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001185.5	0.83	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0001132.4	0.82	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.81	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002017.3	0.77	NRPS	potensibactin	Nocardiopsis potens DSM 45234
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.76	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001185.5	0.73	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.29 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.73 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.71 out of 36.53

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

Additional weak hits (34):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.24 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 13.87 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.73 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.44 out of 29.38

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 12.89 out of 18.57

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.67 out of 29.72

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.36 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.57 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.95 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.91 out of 27.78

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 39.62

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.49 out of 29.25

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.56 out of 21.84

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.62 out of 39.62

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.05 out of 21.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.74 out of 26.33

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.80 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.75 out of 29.38

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.87 out of 20.97

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.06 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.48 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.33 out of 24.78

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.27 out of 24.78

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.56 out of 23.43

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.12 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.95 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.71 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.23 out of 32.74

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.93 out of 27.04

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.00 out of 31.73

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.58 out of 26.85

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 142180 - 208569:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Ser - D-Ser) + (X - OH-Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FZ103_RS20135: X - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (487..888): X

nrpys: Ac-OH-Orn, OH-Orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTAGFDVAFWEMGLLAGTEFNCYGPTETTVNATL
Nearest Stachelhaus code(s):: Ac-OH-Orn DVWALGAVNK (71% 8Å match); OH-Orn DVWALGAVNK (68% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1550..1959): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSHWFDAAWQPWEVGVGGEFNLYGPTEATVDALA
Nearest Stachelhaus code(s):: OH-Orn DAQEGGLVDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

FZ103_RS20140: Gly - Ser - Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (493..884): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FDMTFDISALELQALVGGEVNLYGPTETTIWSTA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1553..1957): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEANLYGPTEAAVDVTA
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2622..3027): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEANLYGPTEAAVDVTA
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

FZ103_RS20165: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..445): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SASLFPMSSPGGAVQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_VTZW01000019.1 - Region 2 - terpene-precursor

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Location: 331,179 - 352,219 nt. (total: 21,041 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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KnownClusterBlast

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: transketolase

FZ103_RS20820: transketolase

smcogs: SMCOG1204: transketolase

Ligases: ligase synthetase

FZ103_RS20805: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

FZ103_RS20825: carboxylate-amine ligase

smcogs: SMCOG1165: carboxylate-amine ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002162.3	0.50	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0000657.5	0.46	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0002400.2	0.43	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001911.3	0.37	terpene	raimonol	Streptomyces anulatus
BGC0001075.5	0.36	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0000678.5	0.35	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000644.3	0.35	terpene	carotenoid	Dietzia sp. CQ4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002162.3	0.50	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0000657.5	0.46	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0002400.2	0.43	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001911.3	0.37	terpene	raimonol	Streptomyces anulatus
BGC0001075.5	0.36	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0000678.5	0.35	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000644.3	0.35	terpene	carotenoid	Dietzia sp. CQ4

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

FZ103_RS20805: PT_FPPS_like

Domain 1 (59 - 344): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.46 out of 20.47

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.34 out of 20.97

Confidence: medium

Additional weak hits (10):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.23 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.11 out of 29.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.91 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.27 out of 27.78

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.46 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.76 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.01 out of 26.06

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.06 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.07 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_VTZW01000019.1 - Region 3 - T1PKS

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Location: 371,713 - 435,261 nt. (total: 63,549 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FZ103_RS21040: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

FZ103_RS21145: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

FZ103_RS25910: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase kinase

FZ103_RS20985: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

FZ103_RS21150: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Ligases: synthase

FZ103_RS20950: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

FZ103_RS21045: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000041.3	0.68	PKS	oronofacic acid	Pseudomonas syringae
BGC0001275.3	0.67	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000041.3	0.68	PKS	oronofacic acid	Pseudomonas syringae
BGC0001275.3	0.67	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 17.93 out of 23.79

Confidence: medium

Additional weak hits (28):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.26 out of 39.62

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.08 out of 19.26

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.63 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.61 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.56 out of 21.84

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.54 out of 19.26

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 17.94 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.21 out of 28.19

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.60 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.10 out of 30.11

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 15.58 out of 29.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 16.81 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.32 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.66 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 11.90 out of 26.06

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.67 out of 29.72

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 16.77 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.21 out of 30.97

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.84 out of 36.53

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.66 out of 23.43

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.84 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.85 out of 28.14

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.45 out of 29.25

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.34 out of 39.62

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.32 out of 30.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.18 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.75 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 14.80 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 371712 - 435261:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-redmal) + (Me-ohmal) + (pk)
Non-colinear ordering:: FZ103_RS25910 + FZ103_RS21045 + FZ103_RS21040

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FZ103_RS21040: pk

PKS_AT (597..896): pk

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 198.9
Methylmalonyl-CoA: 190.9
Methoxymalonyl-CoA: 159.0
2-Methylbutyryl-CoA: 122.6
trans-1,2-CPDA: 95.9
Malonyl-CoA: 94.1
Propionyl-CoA: 89.9
Isobutyryl-CoA: 73.6
CHC-CoA: 69.0
Benzoyl-CoA: 63.1
Acetyl-CoA: 46.0
inactive: 41.6
3-Methylbutyryl-CoA: 24.7
fatty_acid: 23.3

FZ103_RS21045: mmal

PKS_AT (530..844): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 198.6
Ethylmalonyl-CoA: 187.7
2-Methylbutyryl-CoA: 163.2
Methoxymalonyl-CoA: 162.6
trans-1,2-CPDA: 125.6
Propionyl-CoA: 113.0
Malonyl-CoA: 91.6
CHC-CoA: 78.7
Isobutyryl-CoA: 75.7
Benzoyl-CoA: 55.4
3-Methylbutyryl-CoA: 48.9
Acetyl-CoA: 47.2
inactive: 43.7
fatty_acid: 21.9

FZ103_RS25910: mal - mmal

PKS_AT (588..893): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.1
inactive: 61.6
Methoxymalonyl-CoA: 61.0
Methylmalonyl-CoA: 50.2
Isobutyryl-CoA: 31.9
Propionyl-CoA: 23.0
Ethylmalonyl-CoA: 19.4
Acetyl-CoA: 17.4
CHC-CoA: 13.1
2-Methylbutyryl-CoA: 10.8
Benzoyl-CoA: 5.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1944..2241): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.0
Ethylmalonyl-CoA: 176.2
Methoxymalonyl-CoA: 162.9
2-Methylbutyryl-CoA: 141.5
trans-1,2-CPDA: 118.4
Propionyl-CoA: 97.7
Malonyl-CoA: 91.2
Isobutyryl-CoA: 82.1
CHC-CoA: 74.1
Acetyl-CoA: 52.7
inactive: 45.0
Benzoyl-CoA: 39.5
3-Methylbutyryl-CoA: 26.8
fatty_acid: 22.3

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_VTZW01000015.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 179,183 - 205,443 nt. (total: 26,261 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

FZ103_RS15810: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Lyases: cyclase

FZ103_RS15835: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

FZ103_RS15845: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.60	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.57	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5	0.56	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002663.2	0.50	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.60	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.57	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5	0.56	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002663.2	0.50	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FZ103_RS15835

FZ103_RS15840

Leader:

MNRITRDAETGYVPEEELLQLTEPADDLVAGA

Core:

AEVQSTTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

Core with dehydrations:

AEVQDhaDhbDhbVVCysGIDhaAVDhbDhaAIDhbAADhaAAMGDNCysPDhbDhbACysDhbDhbYCys

antiSMASH-DB 4.0 matches for FZ103_RS15840

100.0%

NZ_VTZW01000015.1and 1 other:

NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15840_lanthipeptide

Lanthipeptides: FZ103_RS15840_lanthipeptide

1

AEVQSTTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

AEVQSTTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

1

AEVQSTTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

46.2%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

+TTV C A+ + A SAA+ D CPT ACTT C

3

TTTVPC---AIGGGVIAISAALPDFCPTGACTTRC

34

43.6%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide

Lanthipeptides: BUE45_RS13105_lanthipeptide

12

ISAVTSAITAASAAMGDNCPTTACTTYC

39

ISA +++TA SAA GD CPTT CT+ C

1

ISATVASVTAISAAWGDGCPTTVCTSRC

28

with 74 more sequence matches

Only the first 10 are displayed here.

43.6%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

STTV CGI S IT + A CPT+ CT C

2

STTVPCGIG---STITISIAY----CPTSKCTERC

29

41.9%

NZ_BNBV01000031.1and 3 others:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22990_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide

Lanthipeptides: IE286_RS22990_lanthipeptide

2

EVQSTTVVCGISAVTSAIT-AASAAMGDNCPTTACTTYC

39

E+ V G + V+ A+T AASAA CPTT CT C

8

ELSEADVTGGTTPVSIAVTVAASAAF---CPTTKCTNDC

43

41.0%

NZ_BQXZ01000001.1and 1 other:

NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05005_lanthipeptide

Lanthipeptides: OCU69_RS05005_lanthipeptide

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

ST +V ISA ++ TA SA T+ACTT C

1

STPIVSAISATVASATAISALFTV---TSACTTKC

32

41.0%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

8

VVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

+V ISAVT A+TA S CPT+AC+ C

10

IVTAISAVT-AVTAQSP-----CPTSACSKSC

35

41.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide

Lanthipeptides: MT347_RS12965_lanthipeptide

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

+TT C ++ +T AA+AA+ CPT ACTT C

1

TTTAPCAVAGLT---IAATAALPGFCPTGACTTRC

32

38.1%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

1

AEVQ-STTVVCGISAVTSAITAASAAMGDN-CPTTACTTYC

39

AEV TTV C + T IT + CPT+AC++ C

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

37.2%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35805_lanthipeptide

Lanthipeptides: TNCT1_RS35805_lanthipeptide

2

EVQSTTVVCGISAVTSAIT-AASAAMGDNCPTTACTTYC

39

E+ V G + V+ A+T AAS A CPT CT+ C

8

ELSEADVTGGTTPVSIAVTVAASVAF---CPTIKCTSAC

43

35.9%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

16

TSAITAASAAMGDN-CPTTACTTYC

39

T I A SA + D CPTTACT C

8

TPVIVAVSAYVSDKTCPTTACTRAC

32

35.9%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

12

ISAVTSAITAASAAMGDN-CPTTACTTYC

39

+ A T A+TA S + N CP+TACT C

5

VLATTGALTAVSGYISSNTCPSTACTRAC

33

35.9%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

15

VTSAITAASAAMGDN-CPTTACTTYC

39

V+ A+TA S + N CPTTACT C

5

VSIALTAVSGYISSNTCPTTACTRAC

30

MIBiG 4.0 matches for FZ103_RS15840

35.9%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

6

TTVVCGISAVTSAI-TAASAAMGDNCPTTACTTYC

39

T ++ GI A+ + + SAA CPTT CT+ C

6

TGLILGIVAIQAGVAVGVSAAF---CPTTKCTSRC

37

17.9%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

30

CPTTACTTYC

39

CPTT CT+ C

17

CPTTKCTSKC

26

FZ103_RS15850

Leader:

MPNPNVGILDEIDEQNIADTTVGA

Core:

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

Core with dehydrations:

DANDhaIDhaIADhbACysVDhaCysLADhaWAVGNEGWACysDhbVDhbVECysQDGCys

antiSMASH-DB 4.0 matches for FZ103_RS15850

100.0%

NZ_VTZW01000015.1and 1 other:

NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15850_lanthipeptide

Lanthipeptides: FZ103_RS15850_lanthipeptide

1

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

1

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

67.5%

NZ_FQZK01000006.1and 1 other:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13115_lanthipeptide

Lanthipeptides: BUE45_RS13115_lanthipeptide

1

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

D NSISIA+ C SCLASWA+GN GWACT++VECQ C

4

DPNSISIASLCPSCLASWAIGNPGWACTLSVECQGSC

40

48.6%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

7

IATACVSC-LASWAVGNEGWACTVTVECQDGC

37

+A + VSC L S+A+GN+GW CT T ECQ C

5

VAKSIVSCSLISFALGNDGWICTWTAECQATC

36

with 102 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

3

NSISIATACVSCLA-SWAVGNEGWACTVTVECQDGC

37

N+IS +T C+A S VGN+G CT TVEC + C

4

NTISTST----CIAVSHFVGNDGKVCTYTVECVNNC

35

45.9%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide

Lanthipeptides: LL065_RS24800_lanthipeptide

6

SIATACVSCLASWAVGNEGWACTVTVECQDGC

37

+I V CLAS+A+GN+G CT +VECQ+ C

5

TILQGTVGCLASYALGNQGKICTWSVECQNNC

36

45.9%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

5

ISIATACVSCLA-SWAVGNEGWACTVTVECQDGC

37

I +SC SWA+GN+G CT TVECQ C

3

IGTTVTTLSCYGVSWALGNDGNFCTATVECQSNC

36

43.2%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

7

IATACVSC-LASWAVGNEGWACTVTVECQDGC

37

+A + SC L S +GN+GW CT T ECQ C

5

VAKSITSCSLLSIGLGNDGWVCTWTAECQATC

36

43.2%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

15

LASWAVGNEGWACTVTVECQDGC

37

+ASWA+GN G CTVTVECQ C

10

VASWALGNNGHLCTVTVECQKNC

32

43.2%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

1

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

D N+++ +T S L S +GN GW CT T EC C

2

DTNTLTTST---SILISMTLGNNGWVCTATKECMPSC

35

42.5%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

2

ANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

A +I + AC + AS+ +GN G CT+TVECQ C

6

AETILTSLACAA--ASYILGNPGHVCTLTVECQKKC

39

40.5%

NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

7

IATACVSCLASWAVGNEGWACTVTVECQDGC

37

I T V+ S +GN+G+ CTVTVEC C

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNC

31

40.5%

NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide

Lanthipeptides: O1G21_RS35415_lanthipeptide

16

ASWAVGNEGWACTVTVECQDGC

37

ASWA+GN G+ CTVT ECQ C

14

ASWAMGNNGYLCTVTAECQKNC

35

39.5%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

12

VSCLA-SWAVGNEGWACTVTVECQDGC

37

+SCLA S +G++G CT TVECQ+ C

10

LSCLAASIMIGDKGQVCTGTVECQNNC

36

MIBiG 4.0 matches for FZ103_RS15850

32.4%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

17

SWAVGNEGWACTVTVECQDGC

37

S A+GN G CT+T ECQ C

9

SNALGNNGGWCTLTKECQPNC

29

27.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

20

VGNEGWACTVTVECQDGC

37

+GN+G CT+TVEC C

10

LGNKGAYCTLTVECMPSC

27

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTVTVECQDGC

37

CT++ ECQ C

28

CTLSKECQPNC

38

allorf_199757_199942

Leader:

MLIGSRHCCGVEGVPGA

Core:

GERSRPSGSSARLRGSRRRGRSRACACRAGLPRLHVTGGAAART

Core with dehydrations:

GERDhaRPDhaGDhaDhaARLRGDhaRRRGRDhaRACysACysRAGLPRLHVDhbGGAAARDhb

antiSMASH-DB 4.0 matches for allorf_199757_199942

100.0%

NZ_VTZW01000015.1:

Lanthipeptides: allorf_199757_199942_lanthipeptide

1

GERSRPSGSSARLRGSRRRGRSRACACRAGLPRLHVTGGAAART

44

GERSRPSGSSARLRGSRRRGRSRACACRAGLPRLHVTGGAAART

1

GERSRPSGSSARLRGSRRRGRSRACACRAGLPRLHVTGGAAART

44

13.0%

NZ_JAGGRJ010000031.1:

Lanthipeptides: allorf_023069_023305_lanthipeptide

26

ACRAGLPRLH

35

AC+A +PR+H

6

ACKARMPRIH

15

MIBiG 4.0 matches for allorf_199757_199942

11.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

9

SSARLRGSRRRGRSRACACRAGLP

32

S+ R + AC + LP

24

DSSMFDDESSRPAAPACHTLSSLP

47

Lanthipeptide(s) for FZ103_RS15845

FZ103_RS15840

Leader:

MNRITRDAETGYVPEEELLQLTEPADDLVAGA

Core:

AEVQSTTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

Core with dehydrations:

AEVQDhaDhbDhbVVCysGIDhaAVDhbDhaAIDhbAADhaAAMGDNCysPDhbDhbACysDhbDhbYCys

antiSMASH-DB 4.0 matches for FZ103_RS15840

100.0%

NZ_VTZW01000015.1and 1 other:

NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15840_lanthipeptide

Lanthipeptides: FZ103_RS15840_lanthipeptide

1

AEVQSTTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

AEVQSTTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

1

AEVQSTTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

46.2%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

+TTV C A+ + A SAA+ D CPT ACTT C

3

TTTVPC---AIGGGVIAISAALPDFCPTGACTTRC

34

43.6%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide

Lanthipeptides: BUE45_RS13105_lanthipeptide

12

ISAVTSAITAASAAMGDNCPTTACTTYC

39

ISA +++TA SAA GD CPTT CT+ C

1

ISATVASVTAISAAWGDGCPTTVCTSRC

28

with 74 more sequence matches

Only the first 10 are displayed here.

43.6%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

STTV CGI S IT + A CPT+ CT C

2

STTVPCGIG---STITISIAY----CPTSKCTERC

29

41.9%

NZ_BNBV01000031.1and 3 others:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22990_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide

Lanthipeptides: IE286_RS22990_lanthipeptide

2

EVQSTTVVCGISAVTSAIT-AASAAMGDNCPTTACTTYC

39

E+ V G + V+ A+T AASAA CPTT CT C

8

ELSEADVTGGTTPVSIAVTVAASAAF---CPTTKCTNDC

43

41.0%

NZ_BQXZ01000001.1and 1 other:

NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05005_lanthipeptide

Lanthipeptides: OCU69_RS05005_lanthipeptide

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

ST +V ISA ++ TA SA T+ACTT C

1

STPIVSAISATVASATAISALFTV---TSACTTKC

32

41.0%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

8

VVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

+V ISAVT A+TA S CPT+AC+ C

10

IVTAISAVT-AVTAQSP-----CPTSACSKSC

35

41.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide

Lanthipeptides: MT347_RS12965_lanthipeptide

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

+TT C ++ +T AA+AA+ CPT ACTT C

1

TTTAPCAVAGLT---IAATAALPGFCPTGACTTRC

32

38.1%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

1

AEVQ-STTVVCGISAVTSAITAASAAMGDN-CPTTACTTYC

39

AEV TTV C + T IT + CPT+AC++ C

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

37.2%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35805_lanthipeptide

Lanthipeptides: TNCT1_RS35805_lanthipeptide

2

EVQSTTVVCGISAVTSAIT-AASAAMGDNCPTTACTTYC

39

E+ V G + V+ A+T AAS A CPT CT+ C

8

ELSEADVTGGTTPVSIAVTVAASVAF---CPTIKCTSAC

43

35.9%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

16

TSAITAASAAMGDN-CPTTACTTYC

39

T I A SA + D CPTTACT C

8

TPVIVAVSAYVSDKTCPTTACTRAC

32

35.9%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

12

ISAVTSAITAASAAMGDN-CPTTACTTYC

39

+ A T A+TA S + N CP+TACT C

5

VLATTGALTAVSGYISSNTCPSTACTRAC

33

35.9%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

15

VTSAITAASAAMGDN-CPTTACTTYC

39

V+ A+TA S + N CPTTACT C

5

VSIALTAVSGYISSNTCPTTACTRAC

30

MIBiG 4.0 matches for FZ103_RS15840

35.9%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

6

TTVVCGISAVTSAI-TAASAAMGDNCPTTACTTYC

39

T ++ GI A+ + + SAA CPTT CT+ C

6

TGLILGIVAIQAGVAVGVSAAF---CPTTKCTSRC

37

17.9%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

30

CPTTACTTYC

39

CPTT CT+ C

17

CPTTKCTSKC

26

FZ103_RS15850

Leader:

MPNPNVGILDEIDEQNIADTTVGA

Core:

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

Core with dehydrations:

DANDhaIDhaIADhbACysVDhaCysLADhaWAVGNEGWACysDhbVDhbVECysQDGCys

antiSMASH-DB 4.0 matches for FZ103_RS15850

100.0%

NZ_VTZW01000015.1and 1 other:

NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15850_lanthipeptide

Lanthipeptides: FZ103_RS15850_lanthipeptide

1

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

1

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

67.5%

NZ_FQZK01000006.1and 1 other:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13115_lanthipeptide

Lanthipeptides: BUE45_RS13115_lanthipeptide

1

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

D NSISIA+ C SCLASWA+GN GWACT++VECQ C

4

DPNSISIASLCPSCLASWAIGNPGWACTLSVECQGSC

40

48.6%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

7

IATACVSC-LASWAVGNEGWACTVTVECQDGC

37

+A + VSC L S+A+GN+GW CT T ECQ C

5

VAKSIVSCSLISFALGNDGWICTWTAECQATC

36

with 102 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

3

NSISIATACVSCLA-SWAVGNEGWACTVTVECQDGC

37

N+IS +T C+A S VGN+G CT TVEC + C

4

NTISTST----CIAVSHFVGNDGKVCTYTVECVNNC

35

45.9%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide

Lanthipeptides: LL065_RS24800_lanthipeptide

6

SIATACVSCLASWAVGNEGWACTVTVECQDGC

37

+I V CLAS+A+GN+G CT +VECQ+ C

5

TILQGTVGCLASYALGNQGKICTWSVECQNNC

36

45.9%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

5

ISIATACVSCLA-SWAVGNEGWACTVTVECQDGC

37

I +SC SWA+GN+G CT TVECQ C

3

IGTTVTTLSCYGVSWALGNDGNFCTATVECQSNC

36

43.2%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

7

IATACVSC-LASWAVGNEGWACTVTVECQDGC

37

+A + SC L S +GN+GW CT T ECQ C

5

VAKSITSCSLLSIGLGNDGWVCTWTAECQATC

36

43.2%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

15

LASWAVGNEGWACTVTVECQDGC

37

+ASWA+GN G CTVTVECQ C

10

VASWALGNNGHLCTVTVECQKNC

32

43.2%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

1

DANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

D N+++ +T S L S +GN GW CT T EC C

2

DTNTLTTST---SILISMTLGNNGWVCTATKECMPSC

35

42.5%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

2

ANSISIATACVSCLASWAVGNEGWACTVTVECQDGC

37

A +I + AC + AS+ +GN G CT+TVECQ C

6

AETILTSLACAA--ASYILGNPGHVCTLTVECQKKC

39

40.5%

NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

7

IATACVSCLASWAVGNEGWACTVTVECQDGC

37

I T V+ S +GN+G+ CTVTVEC C

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNC

31

40.5%

NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide

Lanthipeptides: O1G21_RS35415_lanthipeptide

16

ASWAVGNEGWACTVTVECQDGC

37

ASWA+GN G+ CTVT ECQ C

14

ASWAMGNNGYLCTVTAECQKNC

35

39.5%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

12

VSCLA-SWAVGNEGWACTVTVECQDGC

37

+SCLA S +G++G CT TVECQ+ C

10

LSCLAASIMIGDKGQVCTGTVECQNNC

36

MIBiG 4.0 matches for FZ103_RS15850

32.4%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

17

SWAVGNEGWACTVTVECQDGC

37

S A+GN G CT+T ECQ C

9

SNALGNNGGWCTLTKECQPNC

29

27.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

20

VGNEGWACTVTVECQDGC

37

+GN+G CT+TVEC C

10

LGNKGAYCTLTVECMPSC

27

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTVTVECQDGC

37

CT++ ECQ C

28

CTLSKECQPNC

38

FZ103_RS15905

Leader:

MSREITEVPAG

Core:

TWNRRGFRKSSYSQSEAACVEVADWDTAGAIRDTKHRDLGALVFPSPEWRAFLAAVKDGEI

Core with dehydrations:

DhbWNRRGFRKDhaDhaYDhaQDhaEAACysVEVADWDDhbAGAIRDDhbKHRDLGALVFPDhaPEWRAFLAAVKDGEI

antiSMASH-DB 4.0 matches for FZ103_RS15905

100.0%

NZ_VTZW01000015.1:

Lanthipeptides: FZ103_RS15905_lanthipeptide

1

TWNRRGFRKSSYSQSEAACVEVADWDTAGAIRDTKHRDLGALVFPSPEWRAFLAAVKDGEI

61

TWNRRGFRKSSYSQSEAACVEVADWDTAGAIRDTKHRDLGALVFPSPEWRAFLAAVKDGEI

1

TWNRRGFRKSSYSQSEAACVEVADWDTAGAIRDTKHRDLGALVFPSPEWRAFLAAVKDGEI

61

39.3%

NC_021177.1:

Lanthipeptides: SFUL_RS11355_lanthipeptide

9

KSSYSQ-SEAACVEVADWDTAGAIRDTKHRDLGALVFPSPEWRAFLAAVKDGEI

61

KSSYS S+ C+EVA +RD+K D AL+F W F+ AVK GE+

2

KSSYSGGSQGECLEVARGYATVPVRDSKATDGPALMFSPQGWTRFVTAVKHGEL

55

21.3%

NZ_KB900614.1:

Lanthipeptides: SALPAC6_RS0114115_lanthipeptide

30

AIRDTKHRDLGALVFPSPEWRAFLAAVKDG

59

A RD+K + AL+F W FL KDG

2

ACRDSKDPNGPALLFGRTAWTNFLTETKDG

31

allorf_199757_199942

Leader:

MLIGSRHCCGVEGVPGA

Core:

GERSRPSGSSARLRGSRRRGRSRACACRAGLPRLHVTGGAAART

Core with dehydrations:

GERDhaRPDhaGDhaDhaARLRGDhaRRRGRDhaRACysACysRAGLPRLHVDhbGGAAARDhb

antiSMASH-DB 4.0 matches for allorf_199757_199942

100.0%

NZ_VTZW01000015.1:

Lanthipeptides: allorf_199757_199942_lanthipeptide

1

GERSRPSGSSARLRGSRRRGRSRACACRAGLPRLHVTGGAAART

44

GERSRPSGSSARLRGSRRRGRSRACACRAGLPRLHVTGGAAART

1

GERSRPSGSSARLRGSRRRGRSRACACRAGLPRLHVTGGAAART

44

13.0%

NZ_JAGGRJ010000031.1:

Lanthipeptides: allorf_023069_023305_lanthipeptide

26

ACRAGLPRLH

35

AC+A +PR+H

6

ACKARMPRIH

15

MIBiG 4.0 matches for allorf_199757_199942

11.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

9

SSARLRGSRRRGRSRACACRAGLP

32

S+ R + AC + LP

24

DSSMFDDESSRPAAPACHTLSSLP

47

allorf_202437_202625

Leader:

MRKGRREAGNRRTPPGS

Core:

GLRCVRGVLGDGAQADPRRCASHRLAQAPPLTGCPPLPAASLSRP

Core with dehydrations:

GLRCysVRGVLGDGAQADPRRCysADhaHRLAQAPPLDhbGCysPPLPAADhaLDhaRP

antiSMASH-DB 4.0 matches for allorf_202437_202625

100.0%

NZ_VTZW01000015.1:

Lanthipeptides: allorf_202437_202625_lanthipeptide

1

GLRCVRGVLGDGAQADPRRCASHRLAQAPPLTGCPPLPAASLSRP

45

GLRCVRGVLGDGAQADPRRCASHRLAQAPPLTGCPPLPAASLSRP

1

GLRCVRGVLGDGAQADPRRCASHRLAQAPPLTGCPPLPAASLSRP

45

20.0%

NZ_KV797630.1:

Lanthipeptides: HMPREF2609_RS10940_lanthipeptide

12

GAQADPRRCASHRLAQAPPLTGCP

35

G ++DP +C ++A P+TG P

1

GKKSDPAKC-----SKAGPITGVP

19

17.8%

NC_010572.1and 7 others:

NC_010572.1 Lanthipeptides: allorf_5658701_5658922_lanthipeptideNC_010572.1 Lanthipeptides: allorf_5658701_5658922_lanthipeptideNC_010572.1 Lanthipeptides: allorf_5658701_5658922_lanthipeptideNZ_GL877172.1 Lanthipeptides: allorf_5864018_5864239_lanthipeptideNZ_GL877172.1 Lanthipeptides: allorf_5864018_5864239_lanthipeptideNZ_GL877172.1 Lanthipeptides: allorf_5864018_5864239_lanthipeptideNZ_GL877172.1 Lanthipeptides: allorf_5864018_5864239_lanthipeptide

Lanthipeptides: allorf_5658701_5658922_lanthipeptide

31

LTGCPPLPAASLSRP

45

L GCP LP S+ P

15

LCGCPKLPVVSMCSP

29

with 4 more sequence matches

15.6%

NZ_BMJA01000001.1:

Lanthipeptides: allorf_0181822_0181917_lanthipeptide

14

QADPRRCAS

22

QA+P RCAS

9

QAEPHRCAS

17

15.6%

NZ_CP073365.1and 1 other:

NZ_JABMKX010000014.1 Lassopeptides: HQN87_RS23545_lassopeptide

Lassopeptides: KDC22_RS04065_lassopeptide

9

LGDGAQADPRRCASH

23

+ D QADP SH

6

IADSFQADPEEIVSH

20

15.6%

NZ_JACSPZ010000014.1:

Lanthipeptides: allorf_27695_27844_lanthipeptide

21

ASHRLAQAPPLTGCPPL

37

+S L P +TGCP

2

SSDFLDDLPAITGCPFF

18

13.3%

NZ_CP009280.1:

Lassopeptides: P40081_RS38190_lassopeptide

9

LGDGAQADPRRCASH

23

+ D Q+DP SH

6

IADSFQSDPEEIVSH

20

allorf_202511_202738

Leader:

MRTAADLPARHRRALRGRIAGRSQGA

Core:

FAGSPPPGALSARTLWANAPPIESARPVARSPMRRPAARWIPRGRRGCR

Core with dehydrations:

FAGDhaPPPGALDhaARDhbLWANAPPIEDhaARPVARDhaPMRRPAARWIPRGRRGCysR

antiSMASH-DB 4.0 matches for allorf_202511_202738

100.0%

NZ_VTZW01000015.1:

Lanthipeptides: allorf_202511_202738_lanthipeptide

1

FAGSPPPGALSARTLWANAPPIESARPVARSPMRRPAARWIPRGRRGCR

49

FAGSPPPGALSARTLWANAPPIESARPVARSPMRRPAARWIPRGRRGCR

1

FAGSPPPGALSARTLWANAPPIESARPVARSPMRRPAARWIPRGRRGCR

49

20.4%

NZ_CP095740.1:

Lanthipeptides: allorf_1761025_1761225_lanthipeptide

15

LWANAPPIESARPVARSPMRRPAA

38

++A P+ +ARSP+RRP A

2

VFARQEPMHRRSCLARSPLRRPFA

25

18.4%

NC_014098.1:

Lanthipeptides: allorf_2904154_2904300_lanthipeptide

2

AGSPPPGALSARTLWANAP

20

GSP G + L+ANAP

6

VGSPCSGFSAVFVLFANAP

24

with 1 more sequence matches

14.3%

NC_015711.1:

Lanthipeptides: allorf_5704565_5704741_lanthipeptide

30

RSPMRRPAARWIPRG

44

R RRP RW+ R

1

RDEERRPCVRWLSRN

15

allorf_203506_203724

Leader:

MRKSRQVGPHLPGPVGNRNRYAQRTRDADTGDSAASGPGRLPGRAQAPATYGAAALFGA

Core:

LACYIFSLAPFVL

Core with dehydrations:

LACysYIFDhaLAPFVL

antiSMASH-DB 4.0 matches for allorf_203506_203724

100.0%

NZ_VTZW01000015.1:

Lanthipeptides: allorf_203506_203724_lanthipeptide

1

LACYIFSLAPFVL

13

LACYIFSLAPFVL

1

LACYIFSLAPFVL

13

22.7%

NZ_CP054018.1and 2 others:

NZ_KV815277.1 Lanthipeptides: allorf_235630_235746_lanthipeptideNZ_KV820076.1 Lanthipeptides: allorf_135222_135338_lanthipeptide

Lanthipeptides: allorf_0084659_0084775_lanthipeptide

3

CYIFSLA

9

CY+FS+A

13

CYLFSVA

19

allorf_204916_205050

Leader:

MGYDTTVTGA

Core:

AAAIAELWERGEAFSDYFDHCIAARPIPRRAAGT

Core with dehydrations:

AAAIAELWERGEAFDhaDYFDHCysIAARPIPRRAAGDhb

antiSMASH-DB 4.0 matches for allorf_204916_205050

100.0%

NZ_VTZW01000015.1:

Lanthipeptides: allorf_204916_205050_lanthipeptide

1

AAAIAELWERGEAFSDYFDHCIAARPIPRRAAGT

34

AAAIAELWERGEAFSDYFDHCIAARPIPRRAAGT

1

AAAIAELWERGEAFSDYFDHCIAARPIPRRAAGT

34

24.5%

NC_017765.1:

Lanthipeptides: SHJG_RS52475_lanthipeptide

5

AELWERGEAFSDYFDHCI---AARPIPRRAAG

33

AEL E GE +D + + RP+P A G

8

AELREDGEVVNDKRVARVMQASGRPVPACAGG

39

23.5%

NZ_QFWW01000059.1:

Lanthipeptides: allorf_179935_180036_lanthipeptide

21

CIAARPIPRRAAGT

34

C A R +PRR +GT

10

CPAERELPRRRSGT

23

with 3 more sequence matches

14.9%

NZ_CZBP01000025.1:

Lanthipeptides: ARA22_RS13915_lanthipeptide

5

AELWERGEAFSD

16

AE++ GE+FSD

9

AEVFSAGESFSD

20

14.0%

NZ_CP051204.2and 1 other:

NZ_CP051205.1 Lanthipeptides: HF329_RS14580_lanthipeptide

Lanthipeptides: HF324_RS23005_lanthipeptide

17

YFDHCIAARPIPR

29

Y C+A RP P

24

YISSCVATRPSPN

36

13.2%

NZ_CP073318.1:

Lanthipeptides: allorf_01110585_01110794_lanthipeptide

18

FDHCIAARPIPRRAAG

33

F CI RP R + G

19

FGSCITLRPATRTSVG

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47

Confidence: strong

Additional weak hits (9):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.79 out of 30.22

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.56 out of 21.55

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.69 out of 19.26

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.66 out of 29.38

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.75 out of 23.43

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.24 out of 32.74

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.32 out of 20.97

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.30 out of 20.01

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FZ103_RS15840 - Class II

Cleavage pHMM score: -2.70

RODEO score: 0

Monoisotopic mass: 3552.7 Da

Molecular weight: 3555.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3573.0 Da N = 1; 3591.0 Da N = 2; 3609.0 Da N = 3; 3627.0 Da N = 4; 3645.1 Da N = 5; 3663.1 Da N = 6; 3681.1 Da N = 7; 3699.1 Da N = 8

FZ103_RS15850 - Class II

Cleavage pHMM score: -1.90

RODEO score: 0

Monoisotopic mass: 3607.6 Da

Molecular weight: 3610.0 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3628.0 Da N = 1; 3646.0 Da N = 2

allorf_199757_199942 - Class II

Cleavage pHMM score: -2.90

RODEO score: 0

Monoisotopic mass: 4472.5 Da

Molecular weight: 4475.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4493.1 Da N = 1; 4511.1 Da N = 2; 4529.1 Da N = 3; 4547.1 Da N = 4; 4565.1 Da N = 5; 4583.2 Da N = 6

FZ103_RS15840 - Class II

Cleavage pHMM score: -2.70

RODEO score: 0

Monoisotopic mass: 3552.7 Da

Molecular weight: 3555.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3573.0 Da N = 1; 3591.0 Da N = 2; 3609.0 Da N = 3; 3627.0 Da N = 4; 3645.1 Da N = 5; 3663.1 Da N = 6; 3681.1 Da N = 7; 3699.1 Da N = 8

FZ103_RS15850 - Class II

Cleavage pHMM score: -1.90

RODEO score: 0

Monoisotopic mass: 3607.6 Da

Molecular weight: 3610.0 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3628.0 Da N = 1; 3646.0 Da N = 2

FZ103_RS15905 - Class II

Cleavage pHMM score: -3.70

RODEO score: 0

Monoisotopic mass: 6692.4 Da

Molecular weight: 6696.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6714.4 Da N = 1; 6732.4 Da N = 2; 6750.4 Da N = 3; 6768.4 Da N = 4; 6786.5 Da N = 5; 6804.5 Da N = 6; 6822.5 Da N = 7

allorf_199757_199942 - Class II

Cleavage pHMM score: -2.90

RODEO score: 0

Monoisotopic mass: 4472.5 Da

Molecular weight: 4475.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4493.1 Da N = 1; 4511.1 Da N = 2; 4529.1 Da N = 3; 4547.1 Da N = 4; 4565.1 Da N = 5; 4583.2 Da N = 6

allorf_202437_202625 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 4515.4 Da

Molecular weight: 4518.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4536.2 Da N = 1

allorf_202511_202738 - Class II

Cleavage pHMM score: -2.70

RODEO score: 0

Monoisotopic mass: 5226.9 Da

Molecular weight: 5230.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5248.1 Da N = 1; 5266.1 Da N = 2; 5284.1 Da N = 3; 5302.1 Da N = 4

allorf_203506_203724 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 1437.8 Da

Molecular weight: 1438.8 Da

Number of bridges: 1

allorf_204916_205050 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3694.8 Da

Molecular weight: 3697.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3715.1 Da N = 1

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems