LOCUS       NZ_VTZW01000019        21041 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomonospora sp. PA3 scaffold6.1, whole genome shotgun sequence.
ACCESSION   NZ_VTZW01000019
VERSION     NZ_VTZW01000019.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomonospora sp. PA3
  ORGANISM  Streptomonospora sp. PA3
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Streptomonospora.
REFERENCE   1  (bases 1 to 723971)
  AUTHORS   Matroodi,S., Siitonen,V., Baral,B., Yamada,K., Akhgari,A. and
            Metsa-Ketela,M.
  TITLE     Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated
            Halophilic Streptomonospora sp. PA3
  JOURNAL   Front Microbiol 11, 1237 (2020)
   PUBMED   32582127
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 723971)
  AUTHORS   Matroodi,S., Siitonen,V., Baral,B., Yamada,K., Akhgari,A. and
            Metsae-Ketelae,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-2019) Department of Biochemistry, University of
            Turku, Turun Yliopisto, Turku 20014, Finland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2018
            Assembly Method                   :: a5-MiSeq v. MAY-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: GCA_000695235.1
            Genome Coverage                   :: 292.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009728995.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 10:59:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,000
            CDSs (total)                      :: 4,917
            Genes (coding)                    :: 4,877
            CDSs (with protein)               :: 4,877
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 8, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 16S)
            partial rRNAs                     :: 7, 10 (16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 40
            CDSs (without protein)            :: 40
            Pseudo Genes (ambiguous residues) :: 0 of 40
            Pseudo Genes (frameshifted)       :: 8 of 40
            Pseudo Genes (incomplete)         :: 35 of 40
            Pseudo Genes (internal stop)      :: 0 of 40
            Pseudo Genes (multiple problems)  :: 3 of 40
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:29:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 331178
            Orig. end                         :: 352219
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VTZW01000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21041
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21041
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21041
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11041](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11041)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    350..363
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.23"
                     /tool="antismash"
     gene            complement(414..1475)
                     /locus_tag="FZ103_RS20775"
                     /old_locus_tag="FZ103_20765"
     CDS             complement(414..1475)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021446.5"
                     /locus_tag="FZ103_RS20775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20765"
                     /product="DUF2157 domain-containing protein"
                     /protein_id="WP_186356616.1"
                     /transl_table=11
                     /translation="MSESKPARQAALRGLVERGVISSAQAEEVRAALEAADAGPGRVRW
                     TEIAGYIGGGLVLAGGVALATAYWEELSRDLRIGLLAVLAVVAVGGAMVMTGGPQEMRG
                     RRHRLPDVRRRVAGVLLALAAVLAAFSVGIAVDGEPLYLPALVGVAVAAAGYAALPTAV
                     GHVTTWWLAAALAALVVRETGQPDPGDEFLAIGGAWLGLGLAWAALSALGAAAERRLGL
                     GLGAGLALAAGQFLLGWGADGAWGYGATLAVAAACLAYYYADRTAVLLVLGILGITVGL
                     PEMVWDLTDGAIGAAAVLLLAGAVLLVASWLGIRLHRRGNGPQSPAAPSGPPAAGPAQQ
                     PADDAGPRPSAGP"
     misc_feature    1472..1490
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.46"
                     /tool="antismash"
     gene            complement(1713..2756)
                     /gene="pdxA"
                     /locus_tag="FZ103_RS20780"
                     /old_locus_tag="FZ103_20770"
     CDS             complement(1713..2756)
                     /EC_number="1.1.1.262"
                     /GO_function="GO:0050570 - 4-hydroxythreonine-4-phosphate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pdxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153480.1"
                     /locus_tag="FZ103_RS20780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20770"
                     /product="4-hydroxythreonine-4-phosphate dehydrogenase
                     PdxA"
                     /protein_id="WP_156003533.1"
                     /transl_table=11
                     /translation="MPETNSPRSDRPALAVTVGDPVGIGPEITVRTLSEVGTTASARGV
                     VVADPAVLRRAAAVCGLDVRIRALDSWDLPEERDGVIDCFDIGELGETELPWGTVDKRA
                     GAAAVRAIEVATRAAMDRRVAGIVTGPINKEAIWAAGSEHLGHTEMLGALTGVTRQNTM
                     FVVRGKKIFFATRHVSLRTALDQVGADQQVAAIEEALTALRVFGHDEPRLAVAAINPHG
                     GENGAFGTEEIDHLVPAVERVRTAGADVVGPVPADSVFHQLLQDRYDGVLSQYHDQGHI
                     AAKTFDFDGTISVTVGLPILRTSVDHGTAFDIAGTGVADPGTMRSAFLHGCEFSHFADR
                     IRAEYGS"
     gene            complement(2846..4312)
                     /locus_tag="FZ103_RS20785"
                     /old_locus_tag="FZ103_20775"
     CDS             complement(2846..4312)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017592632.1"
                     /locus_tag="FZ103_RS20785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20775"
                     /product="four-carbon acid sugar kinase family protein"
                     /protein_id="WP_343233627.1"
                     /transl_table=11
                     /translation="MAQVLVVADDLTGANATGARFARAGMRVATVTPEQAPRAARDYDA
                     VVINLDSRHVPAEQAGRLVADAVASAWPAGLVVKRTDTTLRGNVGAELEAAWRTVRERV
                     PEPTPVRALFAPAFPASGRVTVDGVQLLDGVPLERGELALDPLNPMHTSVVADIVGAQT
                     DLPLRHVPLRRVAQGPLAADLAAGDEPVVLCDALTEQHLADIAEAAAQVHRDTGTVWLA
                     VDPGPAGALLAEALQLRGRAAAAGPLLGVVGSATELTRRQLDAAARSGPVRFVDVDAAR
                     LAGGEAGYRAAIARQLADHLAAAAFPEPVVLRTAQSARDVVELPSAAKLALPGLLAGLV
                     AEVVDSAGAAVPSGLYTSGGEVTSAVLDALHVRAFEVGGEVVPLAVHGRISGGVLDGIP
                     VVTKGGLVGDDATLVECLAKLRRAVQARLRTVPAEVPEHHAPPAAHSRQVPGERPAPGR
                     DPGAATDHPPGPTDHPPGPPPGPLRTPPRV"
     gene            complement(4324..5766)
                     /locus_tag="FZ103_RS20790"
                     /old_locus_tag="FZ103_20780"
     CDS             complement(4324..5766)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153482.1"
                     /locus_tag="FZ103_RS20790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20780"
                     /product="GntP family permease"
                     /protein_id="WP_156003534.1"
                     /transl_table=11
                     /translation="MDVQLLAALVLGVAAVVAIIVWSRLDAFVGLLAGALVTGVVAGVP
                     VTDLIGHITTGFGDTLAGIGIVIALGVMIGKVLEESGGADALARMFVRAFGKGREDVAM
                     TATGAVVSVPVFCDSGFVILHPLARSLARRYGKPLVGVSLALAGGLAVTHHLVPPTPGP
                     LAAVGLLGADLGTVILAGLVMAGVLVPVVVAYARIMGPRLEPHLDPDLVPDLAGAPAAA
                     RAAGSGAPTGPQDAPAAPAAGGGTAEPAGSGETAEQAKPRVHPALAALPLLLPLLLIVG
                     NTVTAAVAEGSRIAEVFTFIGEPAIALLIGLVIAVYLLPRLHTGRKTVTGWLTAAAASA
                     GMIVFITGAGGAFGEVLRQSGVGDALAEEVSTWPVPLFLMPFLIATFVRIAQGSGTVAI
                     ITAATLSAPLVQSAGVDPTLAVLSACSGSFVFSYVSDSFFWVVTRFTGLTGGAAMKMWT
                     GATTTLWLASIPLLGIAALILG"
     gene            complement(5786..6571)
                     /locus_tag="FZ103_RS20795"
                     /old_locus_tag="FZ103_20785"
     CDS             complement(5786..6571)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017540630.1"
                     /locus_tag="FZ103_RS20795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20785"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_186356617.1"
                     /transl_table=11
                     /translation="MRHQELLDAVVDGIQRVEDLARVLGISPSTVRRGLTELEQAGKVV
                     RTHGGAVPSPSGGELSWTQKSQRNAPAKRRIAALAADLVEDGQVVLLDAGSTTTFIAER
                     LASRSGLTVVTNGLGPMTALHDAEGIELIVIGGRVRRRRGSIVGDYARGVLDRISADIA
                     FIGADGVVPGRGVNCPSPELAAVKELQMRSAREVVVVADSSKLHAGEHHHWAVLPGPHV
                     LVTDDGISDEDARTFGADPSCRLRVVPTAGGPTTPASTD"
     misc_feature    complement(6602..6616)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.06"
                     /tool="antismash"
     misc_feature    6626..6640
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.11"
                     /tool="antismash"
     misc_feature    complement(7869..7883)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.91"
                     /tool="antismash"
     gene            complement(8663..9970)
                     /locus_tag="FZ103_RS20800"
                     /old_locus_tag="FZ103_20790"
     CDS             complement(8663..9970)
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017541260.1"
                     /locus_tag="FZ103_RS20800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20790"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_156003536.1"
                     /transl_table=11
                     /translation="MTQTAAPTTGSGGTAPAPATVLVADRLVRAHAPDLSCPAADLVAG
                     EVGRRGARPVRGALRMSAEPAGAAAATPADVPEHARGHAAVIPGSDPPAGLGAAGLSGA
                     EHPAGDRAAREALDAWLAVAGVPRSVLLAAPRSFCAGVERAIEIVEQALEQRGSPVYVR
                     KQIVHNTHVVADLESRGAVFVDDLDAVPEGATVVFSAHGVSPQVHSQAAERGLSVIDAT
                     CPLVTKVHTEARRFASRGDTVVLIGHAGHEEVEGTLGEAPGRTVLVETPEDAASLEVED
                     PERVSYLTQTTLAVDEAAEVVDALRARFPALRGPSSDDICYATTNRQDALSAIAEEADL
                     VLVMGSDNSSNSRRLVELARRRGTGAHLVDDTGDIRPEWLAGVRTVGLTAGASAPPGLV
                     DAVITALRGLGPLTVREYEITRETIHFTLPPQVRPS"
     gene            complement(10001..11041)
                     /locus_tag="FZ103_RS20805"
                     /old_locus_tag="FZ103_20795"
     CDS             complement(10001..11041)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017607099.1"
                     /locus_tag="FZ103_RS20805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20795"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_156003537.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.3e-62, bitscore:
                     206.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAIDETTGGRPAAEVLAGVRDTVDPALRAAVETLPPSPQAIAAY
                     HFGWRDERGDPIGGAGGKLFRPALCLLAAQAAGGTAEDAVPAAVAVELVHNFSLLHDDV
                     MDGDTTRRHRATAWSVFGMGGAVLAGDALLSLAFDTLAASGHPAAGDAVRRLNATVQRL
                     IDGQSADIDFERRADVDPAECRAMAEAKTGALLGCACGLGAALGGGTPRQVQDLRRFGE
                     LLGLSFQIADDLLGIWGDPATTGKPVHSDLRNRKKTLPVVAALTSAAAESGELAALLAR
                     DRPLHGAELVRAAELVELAGGRSWGERESAVLLERALGHLRSAAAAAAPAAELADLARL
                     ATRRDH"
     gene            complement(11082..12476)
                     /locus_tag="FZ103_RS20810"
                     /old_locus_tag="FZ103_20800"
     CDS             complement(11082..12476)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017541264.1"
                     /locus_tag="FZ103_RS20810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20800"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_156003538.1"
                     /transl_table=11
                     /translation="MTDPTLENARPERLSLDTAAARNLATTTKTPPQMRGITSRWLLRV
                     LPWVQVDGGVYRVNRRFTCTVGDGRVSFVSTGTRVRVVPPELAELPALRGFADTAVLEA
                     LADRFEQREYRPGDVIAAAGDPVDHVFLMAHGKAGVHRAGEYGDDNVVGVLVDGDHFGD
                     AAMEARPGAWQDTVKARTACTVLVLPRNRFQQAVDDSAALRSHLEDVRSRSRRPSNRYG
                     EADIAVAAGHAGEPDLPGTFVDYEASPREYELSVAQTVLRVHTRVADLYNQPMNQVEEQ
                     LRLTVEALRERQEDELVNNRDFGLLHNADLSQRIPTRTGPPTPDDLDELVSRRRKTQVV
                     LAHPRAIAAFGRECSRRGVYPDTLHYDGHAVTGWRGIPMLPCDKIPVTASGTSSILAMR
                     TGEHDQGVVGLHHIGLPDEYQPGLSVRFMGISEKAIMSYLVSTYYSAAVLVPDALGILE
                     NVEIGR"
     gene            complement(12687..14087)
                     /locus_tag="FZ103_RS20815"
                     /old_locus_tag="FZ103_20805"
     CDS             complement(12687..14087)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017623772.1"
                     /locus_tag="FZ103_RS20815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20805"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_156003539.1"
                     /transl_table=11
                     /translation="MTESGVENAEQRLSLGTEAARKLATTTKTPPQMQGITSRWLLRLL
                     PWIEAAGGSYRVNRRLTYTVGDGRVSFVSTGADVRVIPRELCELSLLRDFGDESALEAL
                     AERFIQEEYAPGDVIVEHGGAADRVYLIAHGKVNRLGVGDYGDETVLGTMIDGDHFGSA
                     ALLEDEGSWDATAKAVTPCTVLSLRRSDFQEVAERSEALSAHLAELRSRPAREADPSGE
                     AAIAVAAGHAGEPDLPGTFVDYEGSPREYELSVAQTVLRVHTRVADLYNQPMNQVEEQL
                     RLTVEALRERQEDELVNNRDFGLLHNADLSQRFPTRTGPPTPDDLDELLGTVWKEPSFL
                     LAHPRAIAAFGRECSRRGVYPHSVDVEGHRVPSWRGVPMFPCNKIPVTATRSTSIMLMR
                     TGQEKQGVVGLHQTGLPDEYQPGLSVRFMGISEKAIMSYLVSTYYSAAVLVPDALGILE
                     NVEIGRES"
     misc_feature    complement(14625..14639)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.07"
                     /tool="antismash"
     misc_feature    14642..14655
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.76"
                     /tool="antismash"
     misc_feature    complement(14643..14656)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.01"
                     /tool="antismash"
     misc_feature    14643..14657
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.27"
                     /tool="antismash"
     misc_feature    complement(14648..14657)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     misc_feature    complement(14672..14681)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     gene            complement(14811..>16679)
                     /locus_tag="FZ103_RS20820"
                     /old_locus_tag="FZ103_20810"
                     /pseudo=""
     CDS             complement(14811..>16679)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204: transketolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004559.0"
                     /locus_tag="FZ103_RS20820"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20810"
                     /product="transketolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KTMTDRQRLKELGQQLRVDAVRAADAAGSGHPTSSMSAADLMAVL
                     ASEHLRYDFDSPEHSGNDHLIFSKGHASPLLYALYKACGAISDPELLRYRRLGSPLEGH
                     PTPRLPWVDVATGSLGQGLPIGAGVALAGASLDRLPYRVWVLCGDSELAEGSVWEAMEY
                     AGQAGLANLTAILDINRLGQRGPTRHGWDLDAYRRRVEAFGWHTVEIDGHDIDEIDAAY
                     RRAQEETERPTAIIARTVKGAGVSAVADQEGAHGKPLTDAEQAIAELGGERDLRIEVAA
                     PDSGGVRQRPGGAQVDLPAYEVGEEAATRDAFGQAAAAIGAARPDVVVLDGEVADSTRA
                     KFFAEQHPDRFFEFYIAEQQMVAAAIGLQVRGWTPYAATFAAFFSRAYDFIRMAAVSRA
                     DINLVGSHAGVSIGEDGPSQMGLEDIAALRAVHNSVVLHPCDANSTARLTAGMAEHDGV
                     SYLRTLRGKTPVLYGPDEGFRIGGSKVLRSSPDDRVTVVGAGATVHEALAAADALAGEG
                     IGVRVIDAYSIKPVDAPTLRAAAEETGRIVTVEDHWPEGGLGDAVLDVFADTRSTPRMM
                     KLAVTGMPASATPQEQLREAGIDSGAIEAAVRGILRQEQAPAAAGS"
     gene            complement(16727..17923)
                     /locus_tag="FZ103_RS20825"
                     /old_locus_tag="FZ103_20815"
     CDS             complement(16727..17923)
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042398 - cellular modified amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1165: carboxylate-amine ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017555524.1"
                     /locus_tag="FZ103_RS20825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20815"
                     /product="glutamate--cysteine ligase"
                     /protein_id="WP_156003541.1"
                     /transl_table=11
                     /translation="MVITQAGPRDCTDVPTMGVEEEFFLVEDSGLLSPCSVEVLDGAAS
                     GPGELFGEFTRSQVEAAGPVCATVEDLLAGLRSARLRLAESAARHGARVVAGGVPVLPE
                     AGPQRLNPGSRYHRIAERFGAVADAAGTNCGCHVHVAVPDRDSGVAASNHMRPWLPVLL
                     ALSANSPVCAGADTGYASWRQPRWSRWPTAGPPPPMESARHYETCVAALLESGAALDRR
                     MLYWDVRLSDRHPTVEIRVCDVPATPEESALVAVLVRALVSAALDAAAAGRTPLRRDPA
                     VLRGDLWRAARDGLEGSCPDPLGGGRLRPVHAVLEGAVEHLRPYLDRSGDLEFVRAVLG
                     TLRVRGGGAVRQRAAYARRSRAADVVDYLAEATVTGLDGALAPPPAVLPPAHVRPSGG"
     gene            18262..18903
                     /locus_tag="FZ103_RS20830"
                     /old_locus_tag="FZ103_20820"
     CDS             18262..18903
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017572516.1"
                     /locus_tag="FZ103_RS20830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_20820"
                     /product="phosphoribosyltransferase family protein"
                     /protein_id="WP_343233628.1"
                     /transl_table=11
                     /translation="MQVFRDRDDAGEQLAERVRELGLRDPVVLALPRGGVPVGAVVAER
                     LGAPLDVTVVRKIAVPDFPETAVGAVTAEGAPIMNPKLSRMVRADQDELARSAEEERAE
                     ARRRVAAYRGDRPAPQVAGRDVVVVDDGLATGMSARAALSSLAEQGAASVTLAVPVCSP
                     DAARDLEDVCDRVVCVLSPPQFQAVSLWYERFPQIDDTEVQELLRRAGVA"
     misc_feature    complement(18302..18316)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(19029..19040)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.34"
                     /tool="antismash"
ORIGIN
        1 cctcggccgg gccgccgccc acctgctgtt ccgccgccga ccgggcacct gggagctcgc
       61 attcgaccac gccaaccgcc ccgccgcgcg gttctggccc ggcgcggtcg acgccgtcgc
      121 cgccggccct gtcaccgtcg tcgagcggta tccgcccgag accgcggtgc ccgggaccct
      181 gctccgcttc gacgtcccgg ccccgcagac ctaggttcaa caacgtcggg ggcgccgcct
      241 tcgaggaacc cccgggtacc cctggggcgg ccgccatcgg ggttgcggcg acgggtgcgc
      301 ctcgcctagc gcggtccggc cccatggccg cagccgctgt ggtgtccgga ttcttaacca
      361 ggacgtagac ccgggccccg gatcggcggg cccccttgcg ctgtcggcgc cggctacggc
      421 ccggccgagg ggcgcggtcc ggcgtcgtcc gccggctgct gagcagggcc cgcggcgggc
      481 ggtccgctcg gtgcggccgg ggactgcgga ccgttcccgc gccgatgcag ccggatgccc
      541 agccagctgg cgaccagcag gaccgccccg gccagcagca gcacggccgc ggccccgatc
      601 gcgccgtcgg tcaggtccca gaccatttcg ggcaggccga cggtgatccc gaggatgccc
      661 agcaccagca gcaccgcggt gcggtcggcg tagtagtagg cgaggcaggc cgccgccacc
      721 gccagggtgg cgccgtagcc ccaggcgccg tcggcgcccc aacccagcag gaactggccg
      781 gccgcaagcg ccaatcccgc gcccaggccc agtcccaggc ggcgctcggc cgccgctccc
      841 agggccgaca gggccgccca tgccagtccc agccccagcc acgcgccgcc gatcgccagg
      901 aactcgtcgc cggggtcggg ctgtccggtc tcccgcacga ccagggcggc aagggccgcg
      961 gccagccacc aggtcgtcac gtggcccacg gccgtgggca gggccgcata gcccgcggcc
     1021 gccaccgcga ccccgacgag agccggcagg tagaggggct cgccgtccac ggcgataccc
     1081 accgagaagg cggccagcac cgcggccagc gccagcagca ccccggcgac gcgacggcgg
     1141 acgtcgggca accggtggcg gcgcccgcgc atctcctggg gcccgcccgt catgaccatc
     1201 gctccgccca ccgcgacgac ggccagcacg gccagcagcc cgatgcggag gtcccggctc
     1261 agctcctccc agtaggccgt ggccagcgcg accccgccgg ccagcaccag gccgccgccg
     1321 atgtatccgg cgatctccgt ccagcgcacg cgcccgggac cggcatcggc ggcctccagc
     1381 gcggcccgca cctcctcggc ctgcgcggag gagatgaccc cgcgctcgac gaggccgcgc
     1441 agagccgcct gccgggcggg cttcgactcg ctcacgttgt gctccccttc cgcctgcgac
     1501 gtgcctccgg ggcggccccg gatgcgccca tcccatcgtg gcgggcgcct ggacgcctga
     1561 gtaccactac tcagatcgcc tccgcgaccg catgcgaccg cggccgtggt ggcggacggc
     1621 cggggccggc gggcggcggg gcggcggagg atcgcgcggg gcggccgccg gtgcgccccc
     1681 gtaggcgccg gcgaccgccc gcccgcccgc cgctaggagc cgtactcggc gcggatgcgg
     1741 tcggcgaagt gggagaactc gcagccgtgc aggaacgcgg aacgcatggt gccggggtcc
     1801 gcgaccccgg tgccggcgat gtcgaaggcc gtgccgtggt cgaccgaggt ccgcaggatg
     1861 ggcaggccga cggtgaccga gatggtgccg tcgaagtcga aggtcttcgc ggcgatgtgg
     1921 ccctggtcgt ggtactggga gaggacgccg tcgtagcggt cctgcagcag ctggtggaag
     1981 acggagtcgg cgggcaccgg cccgacgacg tcggcgcccg cggtccgcac ccgctccacc
     2041 gcgggaacca ggtggtcgat ctcctcggtg ccgaaggccc cgttctcccc gccgtggggg
     2101 ttgatggcgg ccaccgccag gcggggctcg tcgtggccga agacccgcag ggcggtgagc
     2161 gcctcctcga tggcggccac ctgctggtcg gcgccgacct ggtccagcgc ggtgcgcagg
     2221 gagacgtggc gggtggcgaa gaagatcttc ttgccccgca caacgaacat ggtgttctgc
     2281 cgggtgacgc cggtgagcgc gcccagcatc tcggtgtggc cgaggtgctc gctgccggcc
     2341 gcccagatcg cctccttgtt gatgggaccg gtgacgatcc cggccacgcg gcggtccatg
     2401 gccgcgcgcg tggcgacctc gatggcgcgg acggcggcgg cgccggcgcg cttgtccacc
     2461 gtgccccagg ggagttcggt ctcgcccagc tcgccgatgt cgaagcagtc gatcacgccg
     2521 tcgcgctcct cgggcaggtc ccaggagtcc agcgcacgga tccgcacgtc cagcccgcac
     2581 accgcggcgg cgcgccgcag cacggccggg tcggcgacca cgacgccgcg ggcggaggcg
     2641 gtcgtgccca cctcgctgag cgtgcgcacg gtgatctcgg gaccgattcc caccggatcg
     2701 ccgacggtga cggcgagggc cgggcggtcg cttcgggggc tgttggtctc gggcatctcg
     2761 cttccctccc aggatgcccg gccgcgctcg cgcggtcggg cgggtgccgg ttcgtttctc
     2821 gtgccgcgcc gccggcgcgg gcggttcaca cccgcggcgg cgtgcgcagc ggccctgggg
     2881 gcgggccggg gggatggtcc gtcgggccgg ggggatgatc ggtcgcggcg ccggggtcgc
     2941 gtcccggggc gggccgctcc ccgggcacct gccgggagtg ggcggcgggc ggggcgtggt
     3001 gctcgggcac ctcggcgggg accgtgcgca ggcgcgcctg caccgcgcgg cgcagcttgg
     3061 ccaggcactc caccagcgtc gcgtcgtcgc cgacgaggcc gcccttggtc acgaccggga
     3121 tcccgtcgag cactcccccg ctgatgcggc cgtgcacggc cagcgggacg acctcgccgc
     3181 ccacctcgaa ggcgcgcacg tgcagggcgt cgagcacggc ggaggtgacc tcgcccccgc
     3241 tggtgtagag gccgctgggc acggcggcgc ctgcgctgtc caccacctcg gcgaccagtc
     3301 cggcaaggag tccgggcagg gcgagcttgg cggcgctggg aagctccacg acgtcgcggg
     3361 ccgactgggc ggtgcgcagt acgacgggtt cggggaaggc ggccgcggcc aggtggtcgg
     3421 cgagctgtcg ggcgatcgcg gcccggtagc cggcctctcc tccggccagg cgggcggcgt
     3481 cgacgtcgac gaaccggacg gggccgctgc gcgccgcggc gtcgagttgg cgacgggtca
     3541 gctcggtggc gctgccgacc acccccagca gcgggccggc cgcggctgcg cggccgcgca
     3601 gctgcagcgc ctcggccagc agcgccccgg ccgggccggg gtcgacggcc agccacaccg
     3661 ttccggtgtc gcggtgcacc tgcgccgcgg cctcggcgat gtcggccagg tgctgctcgg
     3721 tcagcgcgtc gcagagcacg accggttcgt ctccggcggc caggtcggcg gcgagcgggc
     3781 cctgggcgac ccggcgcagc ggcacgtggc gcagcggcag atcggtctgg gcgcccacga
     3841 tgtcggccac gacgctcgtg tgcatcgggt tgagcggatc cagcgccagc tcgccgcgtt
     3901 ccagcgggac cccgtcgagc agctggacac cgtcgacggt gacccgcccc gaggccggga
     3961 acgcgggcgc gaacagggcc cgaaccgggg tcggctcggg cacgcgctcg cgcacggtcc
     4021 gccacgccgc ctcaagctcc gcgccgacgt tgccgcgcag ggtggtgtcg gtgcgcttga
     4081 ccaccaggcc cgccggccag gccgacgcga ccgcgtcggc gaccagccgg ccggcctgct
     4141 cggcgggcac gtggcggctg tcgaggttga tcaccacggc gtcgtagtcg cgggccgcgc
     4201 gcggcgcctg ctcgggggtg accgtggcca cccgcatgcc ggcgcgcgcg aaccgggcgc
     4261 ctgtcgcgtt ggcgccggtg aggtcgtcgg cgacgacgag aacctgggcc acggttgtca
     4321 cccctaaccg agaatcagcg ctgcgatgcc cagcagcggg atgctcgcca gccacagcgt
     4381 ggtggtggcg ccggtccaca tcttcatcgc cgcaccgccg gtgaggccgg tgaagcgggt
     4441 gacgacccag aagaaggagt cgctcacgta ggagaagacg aaggagccgg agcaggcgga
     4501 gagcaccgcg agcgtggggt ccaccccggc cgactgcacc agcggggcgc tgagcgtggc
     4561 cgcggtgatg atggcgacgg tgcccgagcc ctgggcgatg cgcacgaagg tggcgatgag
     4621 gaagggcatc aggaacagcg gcaccggcca ggtcgagacc tcctcggcga gcgcgtcgcc
     4681 gacgcccgac tggcgcagca cctcgccgaa ggctccgccc gcacccgtga tgaagacgat
     4741 catgccggcg gatgcggccg cggcggtgag ccagccggtg acggtcttgc ggccggtgtg
     4801 caggcgcggc agcaggtaga cggcgatgac caggccgatc agcagcgcga tcgcgggttc
     4861 gccgatgaag gtgaacacct cggcgatgcg ggatccttcg gcgacggcgg cggtgacggt
     4921 gttgccgacg atcagcagca gcggcaggag gaggggaagc gcggccagtg ccggatgcac
     4981 gcgcggcttg gcctgttcgg cggtttcgcc ggagccggcc ggctcggcgg tgccgccgcc
     5041 tgcggccgga gccgccgggg cgtcctgcgg gccggtcggg gcgccgctgc ccgcggcacg
     5101 ggcggcggcg ggtgcgccgg cgaggtcggg aaccaggtcg gggtccaggt ggggctccag
     5161 gcgcggtccc atgatgcggg cgtaggccac cacgaccggc accagcacgc ccgccatgac
     5221 cagaccggcc aggatgacgg tacccaggtc ggcgccgagc aggcccacgg cggccagcgg
     5281 tccgggggtg ggcgggacca ggtggtgggt gacggccagg ccgccggcca gcgcgaggga
     5341 cacgcccacc agcggcttgc cgtagcgccg ggcgagcgag cgcgccaggg ggtggaggat
     5401 gacgaagccg gagtcgcaga agaccggcac ggacacgacg gctccggtcg cggtcatcgc
     5461 gacgtcctcg cggcccttgc cgaatgcgcg gacgaacatc cgggccaagg cgtcggcgcc
     5521 gccgctctcc tccaggacct ttccgatcat gacaccgagc gcgatgacga tgccgatgcc
     5581 ggcgagggtg tcgccgaagc cggtggtgat gtggccgatc aggtcggtga ccgggacgcc
     5641 ggcgaccacg ccggtgacca gcgcgccggc cagcaggccg acgaacgcgt ccagccgcga
     5701 ccagacgatg atcgcgacga cagcggcgac gccgaggacc agcgccgcga gcagctgcac
     5761 atccatgtcc gcacctttcg tggggtcaat cggttgacgc aggcgtggtg gggccgcctg
     5821 cggtcggcac gacgcggagc cggcaggagg ggtccgcgcc gaacgtgcgg gcgtcctcgt
     5881 cgctgatgcc gtcatcggtg acgaggacgt gggggccggg cagaaccgcc cagtggtggt
     5941 gctcgcctgc atggagcttg ctggagtcgg cgaccacgac gacttcgcgg gcgctgcgca
     6001 tctgcagctc cttgacggcc gccagttccg ggctggggca gttgacgccg cgcccgggga
     6061 ccacgccgtc ggcgccgatg aaggcgatgt cggcgctgat ccggtcgagc acgccgcgcg
     6121 cgtagtcgcc cacgatggac ccgcgccgcc gccgaacgcg gccgccgatg acgatcagct
     6181 cgatgccttc ggcgtcgtgc agggcggtca tcggccccag cccgttggtg acgacggtga
     6241 gcccggagcg ggatgccaag cgctcggcga tgaaggtcgt ggtgctgcca gcgtcgagca
     6301 ggacgacctg gccgtcctcg acgagatcgg cggccagtgc ggcgatccgc cgcttggcgg
     6361 gtgcgttgcg ctggctcttc tgcgtccagg acagctcgcc gcccgagggg gagggcacag
     6421 cgccgccgtg ggtgcgcacg accttaccgg cctgctcaag ctcggtcagc ccgcgccgca
     6481 cggtggaagg gctgatcccc agcacacggg ccaggtcctc gacccgctgg atgccgtcga
     6541 cgacggcgtc cagcagctcc tgatggcgca ctcccactcc tacttgctca tttcgtgcag
     6601 atgaacagga caataatgac ttggtcgctc attttgcgca agatagggcg ctcaaatcga
     6661 acgaaacatg cagagggggt gggggcgagg gtgggggcga gggtgagagg cgccgggtgg
     6721 ggcggtgggt ggtcgaggtg ggtggtcgag gtgggcgatc agcggttggt gccagcggat
     6781 ggccgtccgc ccggcgaggc gacaagggcg gcgagggctg gccccgcgcc catcggtccc
     6841 ggtgcccgcc ggtgcaggtg ggcgacgggg gcggcgaggg cggcgggtgg cccggcccgc
     6901 gcccatcggt acgggtgccc gccggtgcag gcgagcgacg gaagcagcga ggtcagcggg
     6961 tggcccggcc ccagcgagtc ggccccggtg cccgccggta caggcgagcg acggaagcag
     7021 cgaggtcagc gggtggcccg gcccgcgccc atcggcacgg gtgcccgccg gcacaggcga
     7081 gcgacggaag cagcgacgtc ggtggatggc ccggcccgcg cccatcggca cgggtgcccg
     7141 ccggtgcagg tgtgcgacgg gggcggcgag ggcggcgggt ggccgggccc gcgcccatcg
     7201 gtacgggtgc ccgccggtgc aggtgggcga cgggggcggc caaggtggtc ggcgcatcgg
     7261 gctgcgcgca tgggtgcggc ggtgcgctgg gggtcggggg cgacaggtgc ggcgcggggg
     7321 cgtgttgggg tgtgccgcat ccaccagcac gccgcgaccg aaagcacgta tgcccggttt
     7381 gatttaactc gcttcgatcc cggtcgcgtc gagggtgtcc gtggggccac gctcggcgcc
     7441 gagcgtggcc ccacggacac cctcgactgc ggatccggag gtgcaagccg gacatagcgg
     7501 gcttctgggg cgacggcggg gcgacggcgg ggcgacgaga cgcgccgcgc gaccgccggg
     7561 gcgggctccg gccgcgcggc gggcgatttc aagcgccgaa tcgtcccgag atgtccggta
     7621 tgcgggggcg ccaagacggt ccgcacggcc cggatcggcg atgatcatgg cgtttggagc
     7681 ggaatcggcg cccgaagcgc tccaaacgcg cacctcgtgg caccccggcc gcctccaccc
     7741 cccgccacag gcgggcattc cggacaaacc accccggatt ccttccgcat cccggaagat
     7801 ccgggatgcg acgcgccgcg cagccccacc gcgcgccatc ggcgggcatc gtcgacccgc
     7861 gcgaggcgaa atgcccgaaa agtccccgcc cgggccgtgt cccaggacgg cgggggctgc
     7921 cgtccaggaa cccaccggga accacccggg gcggccacca tcggggctgc ggcaatgggt
     7981 gcgcctcgcg aagcgcggtc acagcttgcc gccgagcgca cgcagcccgt cccaggtgga
     8041 gccgcaccac cggtggcggg cctccgaaac aagggtgcgc cgtgcgctcg gcggcaagct
     8101 ggcgcaccgc gcttcgcgca tcacagcccc attgccgcaa cctcctgtgg tgaccgactc
     8161 cttgaacacg acgtaggcgg cccccaccac cgccctcgcc gccaccgtcg cctgtcgcac
     8221 cggcgggcac cgggttcggt gggctcgggc ccggccatcc gccgccctcg ccgcccccgt
     8281 cggacgatca accggcgagc acccgaaccg gtgggcgcag gctgaaccgc gtgcggccct
     8341 cgttgccctc gtcggatgat caaccggcga gcacccgacc gaatgggctc gggccgagcc
     8401 atccgccgac ctcgctgccc ccgtcgtatg ggccaccggc gggcacccga accgatccgc
     8461 gcgggcaaag cccaccgccg acctcgccgc ccccgtcgca cgggccaccg gcgagcaccc
     8521 gaaccggtgg gcgcaggcga caccacccac cacctccact cccctccccc gcttgccgct
     8581 ccctcccccg ctccccgctc ccctcagcct tctccccctt ccccgctccc ctctcaggcg
     8641 ggctcgtgcc ccccgatcgc tgtcacgatg gacggacctg gggcggcaag gtgaagtgga
     8701 tggtctcgcg ggtgatctcg tattcgcgca cggtcagcgg gcccagtccg cgcaaggcgg
     8761 tgatcaccgc atccaccagt cccggtggcg cggaggcgcc ggcggtcagc ccgacggtgc
     8821 gtacccccgc cagccactcc gggcggatgt cgccggtgtc gtcgacgagg tgggccccgg
     8881 tgccgcggcg ccgggcgagt tccaccagcc gccgggagtt ggaggagttg tccgacccca
     8941 tcaccagcac caggtcggcc tcctcggcga tggccgacag ggcgtcctgg cggttggtgg
     9001 tggcatagca gatgtcgtcg gaggaaggcc cgcgcaaggc ggggaagcgg gcgcgcaggg
     9061 cgtcgacgac ctcggcggcc tcgtcgacgg ccagggtggt ctgggtgagg taggagaccc
     9121 gttcggggtc ctcgacctcc agggacgcgg cgtcctcggg agtctcgacc aggacggttc
     9181 ggcccggggc ctcgccgaga gtgccctcga cctcctcgtg gccggcgtgg ccgatgagca
     9241 cgaccgtgtc tccccgggag gcgaaccggc gggcctcggt gtgcaccttg gtgaccagcg
     9301 ggcaggtggc gtcgatgacg ctgagcccgc gttcggccgc ctggctgtgc acctgcggtg
     9361 agactccgtg cgcggagaag accacggtcg cgccctcggg gaccgcgtcg aggtcgtcga
     9421 cgaagacggc gccccgcgat tcgaggtcgg cgacgacgtg ggtgttgtgc acgatctgct
     9481 tgcgcacgta gacggggctg ccgcgctgct caagcgcctg ctccacgatc tcgatggcgc
     9541 gttcgactcc ggcgcagaaa gagcgcggcg cggcgagcag gacgctgcgc ggcactccgg
     9601 cgacggcgag ccaggcgtcg agggcctcgc gcgcggcccg gtcgcctgcc gggtgctccg
     9661 cgccggagag gccggccgcg cccaggccgg cgggcgggtc ggagccgggg atcaccgcgg
     9721 catggccgcg ggcgtgctcg ggcacgtcgg cgggcgtcgc ggcggcggcg ccggcgggtt
     9781 cggcggacat gcgcagagcc ccgcgcacgg gccgtgcgcc gcggcggccg acttcgccgg
     9841 cgacgaggtc ggccgccggg caggagaggt cgggggcgtg cgcgcgcacg aggcggtcgg
     9901 cgaccaggac ggtggccggg gcgggggccg tcccgcctga tccggtggtc ggtgctgcgg
     9961 tctgggtcat gctgcggtgc ctcctcggct cggccgtcgg tcagtggtcg cggcgggtgg
    10021 ccaggcgggc caggtcggcg agttcggccg cgggcgcggc cgccgcggcg gcggagcgca
    10081 ggtggcccag cgcccgctcc agcaggaccg cgctttcgcg ttcgccccag gagcgtcctc
    10141 cggccagctc caccagctcg gcggcgcgca cgagttcggc gccgtgcagc ggccggtcgc
    10201 gggcgagcag ggccgccagc tcccccgact cggcagcggc ggaggtcagc gcggccacca
    10261 ccggcaaggt cttcttgcgg ttgcgcaggt cggagtggac tggcttgccg gtggtcgcgg
    10321 ggtcgcccca gatgcccagg aggtcgtcgg cgatctggaa ggacagtccc agcagttcgc
    10381 cgaaccgccg caggtcctgt acctggcgcg gtgtgcctcc gccgagggcg gcccccaggc
    10441 cgcaggcgca ccccagcagc gcgccggtct tggcctcggc catggcgcgg cactcggcgg
    10501 ggtcgacgtc ggcgcggcgc tcgaagtcga tgtcggcact ctggccgtcg atgagccgct
    10561 gcacggtggc gttgaggcgg cgcaccgcgt cgccggccgc ggggtggccg gaggccgcca
    10621 gggtgtcgaa ggccagagag agcagcgcgt cgccggccag gacggcgccg cccatgccga
    10681 agacgctcca ggcggtggcg cggtgccgcc gggtggtgtc gccgtccatg acgtcgtcgt
    10741 gcagcagcga gaagttgtgc acgagttcga ccgcgaccgc ggccgggacc gcgtcctcgg
    10801 cggtgccgcc ggcggcctgc gcggccagca ggcacagcgc gggccggaac agcttcccgc
    10861 ccgcgccgcc gatcgggtct ccccgctcgt cgcgccagcc gaagtggtag gcggcgatcg
    10921 cctgcggcga ggggggcagg gtctcgaccg ccgcgcgcag agcggggtcg acggtgtcgc
    10981 ggacgccggc gagtacctcg gccgccggac ggccgcccgt ggtctcatcg attgccacca
    11041 tgaggcgggt cccttctgtg cggtgggtgc cgtcggggcc gtcagcgtcc gatctcgacg
    11101 ttctcgagga tcccgagggc gtcggggacg agtacggcgg cggagtagta ggtgctgacc
    11161 aggtaggaca tgatcgcctt ctcgctgatg cccatgaatc gcaccgacag ccccggctgg
    11221 tactcgtcgg gcaggccgat gtggtggagt ccgacgacgc cctggtcgtg ctcgccggtg
    11281 cgcatcgcga ggatggagct ggtgccggag gcggtgaccg ggatcttgtc gcagggcagc
    11341 atcgggatgc cgcgccagcc ggtcacggcg tgaccgtcgt agtggagggt gtcggggtag
    11401 acgccgcggc ggctgcactc gcggccgaag gcggcgatgg cgcgggggtg ggcgaggacg
    11461 acctgcgtct tgcggcggcg cgagacgagt tcgtcgaggt cgtcgggggt gggcgggccg
    11521 gtgcgggtgg ggatgcgctg gctgaggtcg gcgttgtgca gcagcccgaa gtcgcggttg
    11581 ttgaccagct cgtcctcctg gcgctcccgc agcgcctcca ccgtcagccg cagctgctcc
    11641 tcgacctggt tcatcggctg gttgtagaga tcggccaccc gcgtatgcac ccgcagcacc
    11701 gtctgcgcga cactgagctc gtactcccgc ggcgaggcct cgtagtccac gaacgtcccc
    11761 ggaagatccg gctcccccgc atgccccgcg gccaccgcga tgtcggcctc gccgtacctg
    11821 ttgctcgggc gccgcgaccg ggaccgcacg tcctccaggt gagagcgcag cgcggcggag
    11881 tcgtcgaccg cctgctggaa ccggttccgc ggcaggacca gcacggtgca ggcggtcctg
    11941 gccttgaccg tgtcctgcca ggctccgggc cgggcctcca tcgcggcgtc gccgaagtgg
    12001 tcgccgtcga ccagcacgcc gaccacgttg tcgtcgccgt attcgccggc ccggtgcacg
    12061 ccggccttcc cgtgggccat caggaacacg tggtcgacgg ggtcgccggc ggcggcgatg
    12121 acgtcgcccg gccggtattc gcgctgctcg aagcggtcgg cgagggcctc cagcacggcc
    12181 gtgtcggcga agccccgcag cgcgggcagt tcggcgagct cgggcggcac gacccggacc
    12241 cgggtcccgg tggagacgaa gctgaccctg ccgtctccga cggtgcaggt gaacctccgg
    12301 ttcacccggt agactccgcc gtcgacctgc acccagggca ggacgcgcag cagccatcgg
    12361 gacgtgatcc cgcgcatctg cgggggcgtc ttggtcgtgg tcgcgaggtt gcgcgccgcc
    12421 gcggtatcga ggctcaggcg ctcgggccgg gcgttctcaa gggtcggatc cgtcatgtga
    12481 tgcaccacct aactctgctg gtgtcgggcg ccgatcccgc ggggcgcggg cgtgtccggc
    12541 ggtggaagag gtcgtcggag cggagtcggt cctgatcggg gccgggcggc gcggtgcgga
    12601 cgcgccgccg ccggcgcccg tgcggcctgc gtcggggggc gcggaggggt gccgcacggg
    12661 cgggtcggcg ggcgggggcg gggcggctag ctctcgcgtc cgatctcgac gttctcgagg
    12721 atcccgaggg cgtcggggac gagcacggcg gcggagtagt aggtgctgac caggtaggac
    12781 atgatcgcct tctcgctgat gcccatgaat cgcaccgaca gccccggctg gtactcgtcg
    12841 ggcaggccgg tctggtggag tccgacgacg ccctgcttct cctggccggt gcgcatgagc
    12901 atgatcgagg tgctgcgcgt ggcggtgacc gggatcttgt tgcaggggaa catgggcacg
    12961 ccccgccagg agggcaccct gtggccctcg acgtcgacgc tgtgggggta gacgccgcgg
    13021 cggctgcact cgcggccgaa ggcggcgatg gcgcgggggt gggcgagcag gaaggagggc
    13081 tccttccaca cggtgcccag cagctcgtcg aggtcgtcgg gggtgggcgg gccggtgcgg
    13141 gtggggaagc gctggctgag gtcggcgttg tgcagcagcc cgaagtcgcg gttgttgacc
    13201 agctcgtcct cctggcgctc ccgcagcgcc tccaccgtca gccgcagctg ctcctcgacc
    13261 tggttcatcg gctggttgta gagatcggcc acccgcgtat gcacccgcag caccgtctgc
    13321 gcgacactca gttcgtactc gcggggggag ccctcgtagt ccacgaacgt ccccggaaga
    13381 tccggctccc ccgcatgccc cgcggccacc gcgatcgcgg cctcgccgct gggatcggcc
    13441 tcccgggcgg ggcgggagcg cagctcggcc aggtgcgcgc ttagcgcctc ggagcgctcg
    13501 gcgacctctt ggaagtccga gcgccgcagg gagagaacgg tgcagggggt gacggccttg
    13561 gcggtggcgt cccaggatcc ctcgtcctcg agcagtgcgg ccgagccgaa gtggtcgccg
    13621 tcgatcatgg tccccaggac ggtctcgtcg ccgtagtcgc ccacgcccag ccggttcacc
    13681 ttgccgtggg cgatgaggta gacgcggtcg gcggcgccgc cgtgctcgac gatgacgtcg
    13741 ccgggcgcgt attcctcctg gatgaagcgc tcggccaggg cctccagcgc ggattcgtcg
    13801 ccgaagtcgc gcagcagcga cagctcgcag agttcgcgcg ggatcacccg cacgtcggct
    13861 ccggtggaga cgaagctgac cctgccgtct ccgacggtgt aggtcagccg ccggttgacc
    13921 cggtaggagc cgccggcggc ctcgatccag gggagcaggc gcagcagcca tcgggaggtg
    13981 atgccctgca tctgcggagg ggtcttggtt gtcgtcgcca gtttccgtgc ggcctcggtt
    14041 cccaggctca gccgctgctc cgcgttctcc acgccggact cggtcatggt ggttccaccc
    14101 aatccttcgc tgaccgttga tgctgtgccg attcatttcg acaggcgtgc gcggctctgc
    14161 ggaatccgtc cgcagacccc cgatccgcgg aacgcggtgc ggcgaatgcg ccgtgttctc
    14221 catcgttttc gtttcagcag tccgccgttc tcggggaccc gaatggtcac cggatgcgcg
    14281 ttcgccgcat cccggattcc ggggccgatc ccgtcggtcg ccgcgtcggt gtgtcgatct
    14341 cacgcctggt cggcacccca cgtacccggc ggttccacac gcatgcgccc cgaacgccga
    14401 ctttcatcgc ggacgcacaa cccgccctca tagtccccga attcggcccg tccgcgaaca
    14461 gccggcggcg ttcccgcggc aacccggcgg cctgcgcccc gggatttccg atgggcgtta
    14521 gggacaactg gaatcccgga tcagaaacca ccggcaacgg gaaacacgag ccgcgcacag
    14581 cacccatccg gacattcgga aaacaccgcc gcggcaggac tggaaacaaa agatatccag
    14641 gcttgtatca taaaatagac ccgcaaagcg gtcaaaaaag aagagcagtc cggatgcccc
    14701 gaactgctca gatgtcctaa gttatgcccg gtcttcgttt ttgcccgaga gacgccgaac
    14761 cggagggcgg ggtcctgcgc accccgccct ccggccgggc gggaccgctg tcagctcccc
    14821 gctgcggcgg gggcctgctc ctggcggagg atgccgcgta cggccgcctc gatggccccg
    14881 gagtcgatcc cggcctcgcg gagctgctcc tgcggcgtgg cagacgccgg catgcccgtc
    14941 accgcgagct tcatcatccg cggcgtggac cgggtgtcgg cgaacacgtc gagcacggcg
    15001 tcgcccagtc cgccttcggg ccagtggtcc tcgacggtga cgatacggcc ggtctcctcg
    15061 gcggccgccc gcagggtcgg ggcgtccacc ggcttgatgg agtaggcgtc gatcacccgg
    15121 acgccgatgc cctcgccggc cagggcgtcg gccgcggcca gcgcctcatg gaccgtggca
    15181 ccggcgccca cgaccgtcac ccggtcgtcc ggcgacgaac gcagcacctt gctgccgccg
    15241 atccggaagc cctcatcggg cccgtagagg accggcgtct tgccgcgcag tgtgcgcagg
    15301 tagctcacgc cgtcgtgctc ggccatcccc gcggtgaggc gggcggtgga gttggcgtcg
    15361 caggggtgca ggaccacgct gttgtgcacg gcgcgcaggg cggcgatatc ctccaagccc
    15421 atctgggagg ggccgtcctc cccgatcgac acccccgcgt gggatcccac caggttgatg
    15481 tcggcccggc tgaccgccgc catgcggatg aagtcgtagg cgcgcgagaa gaacgccgcg
    15541 aacgtcgcgg catacggcgt ccagccgcgg acctgcagtc cgatcgcggc ggcgaccatc
    15601 tgctgctcgg cgatgtagaa ctcgaagaag cggtcggggt gctgctcggc gaagaacttg
    15661 gcgcgcgtgg agtcggcgac ctcgccgtcc agcacgacca cgtcggggcg cgcggcgccg
    15721 atcgccgcgg ccgcctggcc gaacgcgtcg cgtgttgcgg cctcctcacc cacctcgtag
    15781 gcgggcaggt ccacctgcgc gccgccgggc cgctggcgca ctcccccgct gtcgggtgcg
    15841 gccacctcga tgcgcaggtc gcgctccccg cccagctcgg cgatggcctg ctcggcgtcg
    15901 gtcagcggct tgccgtgggc gccctcctgg tcggcgaccg cgctgacacc ggcacccttg
    15961 accgtgcggg cgatgatcgc ggtgggccgt tcggtctcct cctgcgcccg gcggtaggcc
    16021 gcgtcgatct cgtcgatgtc gtgtccgtcg atctcgacgg tgtgccagcc gaacgcctcg
    16081 acgcggcgcc ggtaggcgtc caggtcccag ccgtggcggg tcgggccgcg ctggccgagc
    16141 cggttgatgt ccaggatcgc ggtcaggttg gccagacccg cctggccggc gtactccatg
    16201 gcctcccaga ccgagccctc ggcgagctcg ctgtcgccgc acaggaccca cacccggtag
    16261 ggcagccggt ccaggctcgc ccccgccagc gccacgccgg ctccgatcgg caggccctgg
    16321 cccagggagc cggtggcgac gtcgacccac ggcagccgcg gcgtggggtg gccctccagc
    16381 gggctgccca ggcggcgata gcgcagcagc tcgggatcgg agatggcgcc gcaggccttg
    16441 tagagggcgt acagcagcgg cgaggcgtgg cccttggaga agatcaggtg gtcgttgccc
    16501 gagtgctcgg gcgagtcgaa gtcgtagcgc aggtgctccg aggccagcac cgccatcagg
    16561 tccgccgccg acatcgacga ggtcgggtgc cccgaacccg cggcgtcggc ggcgcggacc
    16621 gcgtcgacgc gcaactgctg tcccagctcc ttgagccgtt gccggtcggt catcgtcttc
    16681 ttcctcctcg aatggcgtcg tgccgtggaa cggcaacccg gatccgctac ccgccggagg
    16741 ggcgcacatg cgccggcggc aggaccgcgg gtgggggtgc gagcgccccg tcgaggccgg
    16801 tgacggtggc ctcggccagg tagtcgacga cgtcggcggc gcgggaccgg cgtgcgtagg
    16861 cggcgcgctg ccgtaccgca ccgcccccgc gcacccgcag cgtgccgagc accgcccgca
    16921 cgaactccag atcgccggag cggtcgaggt aggggcgcag gtgctccacg gccccttcca
    16981 gcaccgcgtg caccgggcgc agccgcccgc cgcccagggg gtcggggcag ctgccctcca
    17041 agccgtcgcg cgcggcgcgc cacaggtcgc cgcgcaggac cgccgggtcg cggcggagag
    17101 gggtgcggcc ggcggccgcg gcgtccaggg cggcgctgac cagtgcccgc accagtaccg
    17161 ccaccagcgc ggactcctcg ggtgtggccg ggacgtcgca cacccggatc tcgacggtgg
    17221 ggtggcggtc ggagaggcgg acgtcccagt agagcatccg ccggtccagg gcggcgcccg
    17281 actccagcag ggccgccacg caggtctcgt agtgccgggc cgactccatc ggcggaggcg
    17341 gtcccgcggt gggccagcgc gaccagcggg gctggcgcca gctggcgtat ccggtgtcgg
    17401 cgcccgcgca gaccggggaa ttggcgctca gcgccagcag gaccggcagc cacgggcgca
    17461 tgtggttgct ggccgccacc ccgctgtcgc ggtcgggcac cgccacgtgc acgtggcagc
    17521 cgcagttggt gccggcggcg tcggcgaccg cgccgaagcg ctcggcgatg cggtggtagc
    17581 gcgagcccgg gttgagccgc tggggtccgg cctcggggag caccggaacg cccccggcca
    17641 ccacccgcgc tccgtgccgg gccgccgact cggccaggcg cagccgcgcc gaacgcagcc
    17701 ccgccagcag gtcctccacc gtggcgcaga ccggcccggc ggcctcgacc tggctgcggg
    17761 tgaactcgcc gaacagctcg ccggggcccg atgcggcgcc gtcgaggacc tccacgctgc
    17821 acggtgagag caggcccgaa tcctcgacca ggaagaactc ctcttcgacg cccatcgtcg
    17881 gcacgtccgt gcagtcgcgg gggcctgcct gggtgatgac catagatcac cgccctctcc
    17941 acgtgtcgcc cggctgacgg cggcgccgat cgcgcgcagg ccgttcccgt ggcctcgccg
    18001 ggagccggag gctggtctgg atggtgggcg gcgccgctgc gggccgtggc ccggatgcgg
    18061 cgcggcggcg gccccggcgc gctcgcgccc cgggctgacc gccgtctccc agcgcctacc
    18121 ccgtgcgagc gggcggtaac cgctgcggcg ctgagcgggg cccggtcggg gcggccggcc
    18181 gtggccgccc cgaccggttt ccgccgccgg agcgggggta gccgggcggc gacgacccac
    18241 gacggcgtgg aggtgagggg cgtgcaggtc tttcgcgacc gcgacgacgc cggagagcaa
    18301 ctggccgagc gggtccggga actggggctg cgtgatccgg tggtcctggc gctgccccgc
    18361 ggcggggtac cggtgggcgc cgtcgtcgcc gagcggctgg gggctccgct ggatgtaacc
    18421 gtcgtgcgca agatcgccgt tcccgacttc cccgagacgg cggtgggcgc cgtgacggcc
    18481 gaaggcgccc cgatcatgaa cccgaagctg agccgcatgg tccgggccga ccaggacgag
    18541 ttggcgcgca gcgccgagga ggagcgagcc gaggcccggc ggcgggtcgc ggcctatcgg
    18601 ggcgatcggc ccgcgccgca ggtcgccggc cgcgacgtgg tggtcgtgga cgacgggctc
    18661 gccacgggga tgagcgcccg cgccgcgctg tcgtccctgg ccgagcaggg ggcggcgtct
    18721 gtcaccctgg cggtgccggt ctgctccccc gacgccgccc gcgacctgga ggacgtctgc
    18781 gaccgggtcg tctgcgtact cagcccgccg cagttccagg cggtcagcct gtggtacgag
    18841 cgcttccccc agatcgacga caccgaggtc caggagctcc tgcgccgggc gggggtcgcc
    18901 tagtttccgg gcggagcccg atcccgcaca gccgcgccgg cgggtgaagc gcgtcgttga
    18961 atcgatttta tcgaatccct tcccgcatgc gccgacgcgt gttagattca tcgacctaac
    19021 agagcgctgt aagcgctttc catccccgga cccatagtcc cgaagaacct ggagcagggc
    19081 ctttgcggct gcctgcaccg atccgccgtt tcccgagttc accggcgaac ccgggcggcg
    19141 atccaaagat cgattcatcc cgtcccccat cccatccccc ggtcccgaat gcggccgcgg
    19201 cctttcgccg ctcggccgca tatcggcacg gatgcgagga gtccgccata tgacagcagg
    19261 aatccccccg gccggcgccg gccggccgcg gctcggccgc ggcctcgcgg cagcgacggt
    19321 gctggcgctg ggcgcggccg tgctggccgc ggccccgccc gcgagcgccg ccgccggctg
    19381 cagcgtcgac tacaccgtcc accagtggaa ctccggcttc accgccgacg tgcagatcac
    19441 caacctcggc gaccccgtcg acgggtgggc gctggagtgg gagttcgccg acggccagcg
    19501 gatcaccagc gcatggaacg gcgagtacag ccagtccggc gcgagcgtgc gcgtggagaa
    19561 cgcctcctac aacgccgcca tccccaccgg cggcacggtc gggttcggct ttcaggccac
    19621 ccacaccggc accaacgagg cgcccggcgc cttcacgctc aacggcaccg agtgcgacgg
    19681 ctcggccggc ggccccggag acggcgacga cggcgacgac ggcggcagcg gtgaagaccg
    19741 ctcgggccgc caggtcgagg cgttggaccg cggcctggtc agcgtccgca gcggcggcgg
    19801 caacctgatc agctggcggc tgctggccac cgacccccgc gacgtcgcct tcaacgtcta
    19861 ccgcggcggc acccgggtga actccgagcc cgtcgccggc gccacctcct acctggactc
    19921 ccaggccccc tccggcgccg agtacaccgt gcggcccgtc gtcgacggcc aggagcggca
    19981 ggcgtcgtcg gcggcgctgc ggttcgccga gggctacctg gacgttccgc tgcagcggcc
    20041 cgcgggcggc agcacccccg acggctccta cacctatgcg gccaacgacg ccggcgtggg
    20101 cgacctggac ggcgacggct cctacgagat cgtgctcaag tggcagccga gcaacgccaa
    20161 ggacaactcc cagtcgggct acaccggcaa caccatcgtg gacgcctacg agctcgacgg
    20221 cacccgcctg tggcgcatcg acctgggccg caacatccgc gccggcgcgc actacaccca
    20281 gttcatggtc tacgacctcg acggcgacgg cgccgcggag gtcgcgatga agacgggcga
    20341 cggcaccgtc gacggccggg gcacagtgat cggcgacgcc ggcgccgacc accgcaacgg
    20401 cagcgggttc gtgctgaccg gtccggagta cctgaccgtc ttcgacggcg ccaccggggc
    20461 cgaactgagc accgtcgact accgcccgcc gcgcggcgac ctggaggact ggggcgacga
    20521 ctacggcaac cgcgccgacc ggttcctggc cggggtggcc tacctggacg gcgagcggcc
    20581 cagcctgatc atggcgcgcg gttactacac ccgttcggtg atcgtggcct gggactggcg
    20641 caacggcgag ctcagcgagc gctggacctt cgacagcgac gaggccggct ccgcctggga
    20701 ggggcagggc aaccaccagc tcagcgtggc cgacgccgac ggcgacggcc acgacgagat
    20761 cgtctacggc gcgatggcga tcgacgacga cggcagcggg ctgtggaaca ccggctacgg
    20821 ccacggggac gcgctgcacg tgggcgactt cctgcccgac cgcgacggac tggaggtctt
    20881 cgacctccag gagcggaccg gcggcgaggc cggagcgcac ctggacgacg ccgcgaccgg
    20941 tgagaccatc tggcgcaagc ccacggccga aggcgaagag ggacccggcc gcggcgtggc
    21001 cgccgacgtg tgggccggca accccggcgc cgagttctgg g
//
