LOCUS       NZ_VTZW01000018        20256 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomonospora sp. PA3 scaffold15.1, whole genome shotgun
            sequence.
ACCESSION   NZ_VTZW01000018
VERSION     NZ_VTZW01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomonospora sp. PA3
  ORGANISM  Streptomonospora sp. PA3
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Streptomonospora.
REFERENCE   1  (bases 1 to 69112)
  AUTHORS   Matroodi,S., Siitonen,V., Baral,B., Yamada,K., Akhgari,A. and
            Metsa-Ketela,M.
  TITLE     Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated
            Halophilic Streptomonospora sp. PA3
  JOURNAL   Front Microbiol 11, 1237 (2020)
   PUBMED   32582127
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 69112)
  AUTHORS   Matroodi,S., Siitonen,V., Baral,B., Yamada,K., Akhgari,A. and
            Metsae-Ketelae,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-2019) Department of Biochemistry, University of
            Turku, Turun Yliopisto, Turku 20014, Finland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2018
            Assembly Method                   :: a5-MiSeq v. MAY-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: GCA_000695235.1
            Genome Coverage                   :: 292.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009728995.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 10:59:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,000
            CDSs (total)                      :: 4,917
            Genes (coding)                    :: 4,877
            CDSs (with protein)               :: 4,877
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 8, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 16S)
            partial rRNAs                     :: 7, 10 (16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 40
            CDSs (without protein)            :: 40
            Pseudo Genes (ambiguous residues) :: 0 of 40
            Pseudo Genes (frameshifted)       :: 8 of 40
            Pseudo Genes (incomplete)         :: 35 of 40
            Pseudo Genes (internal stop)      :: 0 of 40
            Pseudo Genes (multiple problems)  :: 3 of 40
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:29:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 20256
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VTZW01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20256
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20256
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20256
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[7997:10256](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7998..10256
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(<1..719)
                     /locus_tag="FZ103_RS19190"
                     /old_locus_tag="FZ103_19175"
                     /pseudo=""
     CDS             complement(<1..719)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FZ103_RS19190"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FZ103_19175"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MISPEDVPIPPVDCDAVEKAGEKLKGDGDDVSQAGQDIKSSWQGL
                     QGIYSAPEQETLFAAIDPVATKGDDFDGAVTSVGTALINFANDVRPIKRRLQTLKADAE
                     SFQSKISGDEDWREDEDKINELDSLNNDILQAVFEYQRAERECANTITALFGGTTFVAT
                     EPGEQGSLGANQVAHGTSEALKDIETPWVTPQEHDAPWWEDVGNGIKDFGVGIAEDLGA
                     LVGLYGEDGWGVSSWSE"
     gene            827..1360
                     /locus_tag="FZ103_RS19195"
                     /old_locus_tag="FZ103_19180"
     CDS             827..1360
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017614707.1"
                     /locus_tag="FZ103_RS19195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19180"
                     /product="putative immunity protein"
                     /protein_id="WP_156003045.1"
                     /transl_table=11
                     /translation="MDTVSGDFELTMDELRAVARYVAQSAEEVLPVFEVARPDDPRPRA
                     AVAAAWEFADGARRTRLQRVTSLDAHRAAKEAPTEAARLAARCAGDAASAAYLHPLADA
                     RQVGHILRAAASAARVAELEAGGDPGVADRAIERARQRAAPVLVDVLRRYPPAATARNR
                     VAELMSTLDSSLRA"
     gene            complement(1463..2494)
                     /locus_tag="FZ103_RS19200"
                     /old_locus_tag="FZ103_19185"
     CDS             complement(1463..2494)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FZ103_RS19200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FZ103_19185"
                     /product="hypothetical protein"
                     /protein_id="WP_156003046.1"
                     /transl_table=11
                     /translation="MVRRIRGSADVGPYDGSPDQQEAKRKWAEREEAHRRFVAKALEIA
                     EFASLGVDRHSPSPIRRLAELSAETMADPQTIAELLNDEGSFREEPWNTITVMSCIEQL
                     WPHSGYFAWPKEFGTYPGYLGGLRDRMGGGEVASNALRIGPGRSQQRCIRCESRWPPGW
                     PGTERESTYPGEPATGCPDCGCPWTSSGLVRGADAREHSIIDLHWMLYRFAPRKPGPCP
                     VCGAERVLANSGRPDWIIIRQLDWACSAADPWASPDPLVPAGRRAAEMEHYRAALEPAE
                     WESEAAHYAYWMAVDVLRVAAANGEEAELPLGAVYEALDGSGQRWVYGSGGWRPVPTEH
                     DDG"
     gene            complement(2586..3359)
                     /locus_tag="FZ103_RS19205"
                     /old_locus_tag="FZ103_19190"
     CDS             complement(2586..3359)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FZ103_RS19205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FZ103_19190"
                     /product="hypothetical protein"
                     /protein_id="WP_156003047.1"
                     /transl_table=11
                     /translation="MSYSAKVSGPVRYLPVELGGEVIGYLYAGVRTSGASFIRRLSAQD
                     VKTGFQAARVWSERLEEGYAARLPAEETLRRWIGAEEHPIAGAVPRRAEFAELGSYEEL
                     RQLANPDHSEPPVPPAPPEPEFFPDGTPTDRSKGWGPLGPFTTNGPGYKMATDSAVRYL
                     PAYRGDVLLGYLWVAETDDAAGFVPRAKARADGHRAERRWIDRMREAESQGLPPSEMLR
                     SWIGAEEDPKAGRLPSDAAEQRAESLDDLRIRARD"
     CDS             complement(3463..>5924)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /codon_start=2
                     /inference="COORDINATES: protein motif:HMM:NF015461.5"
                     /locus_tag="FZ103_RS19210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19195"
                     /product="ADP-ribosyltransferase"
                     /protein_id="WP_222936805.1"
                     /transl_table=11
                     /translation="TKGDDFDGAVTSVGTALINFANDVRPIKRRLQTLKADAESFQSKI
                     SGDEDWREDEDKINELDSLNNDILQAVFEYQRAERECANTITALFGGTTFVATEPGEQG
                     SLGANQVAHGTSEALKDIETPWVTPQEHDAPWWEDVGNGIKDFGVGIAEDLGALVGLYG
                     EGGWGVSSWSEWGSNLKNNWGDTLNGLGSLVGFYGKDGWGVSSFGEWWGNFSSGWTEFA
                     HAVVPWREWGDRPGYVITQSVLNIGSMALGGAGVVKALAKGARKVGGDGSETSGDTNGD
                     TDSNGQPSDGQLQGLQQIGNRPGQQSTQDLQNQLDDMSLDQDQLQGLQNSLDDAEALEN
                     RATPVGGGNDPVDVDPAFNNGNGGQYQSTGNGGGSPGGSGGPGGGSPDGPGSGGHPSDP
                     GGPGGPSGPSGPLGGLDGNGGPDGQQNGNQQDAGNTETPADPVDTDPARPGNTPDGDAP
                     NSDLGETTDPVDTDPVDTDPADTDPVDADTGDTDPADTDPVDTDPVDNVDNNAPAGDTT
                     PGADPDSGIDPNDPSTWPGQVDEDGVRHFDTDDAGEQYGEEVLRPETYERLTESQREGL
                     EDYTRQSWLNPILRGQATTQQILDMKWKSVGPGMHLMDMVDGRISMTDVERAFDNQKDL
                     TEEQRIIVNDIMQSENPDARLEQWIDSAGGRGRMIQTFDGFPTPEEVDQRIADMDAGFQ
                     RTALPEDVEVVRGLHDFSFMKGFDPSSPNAYEALKKMIGETQSDNAYMSTSLGKNPTVV
                     DNNPYEYKFHLNVPEGHPGVWMGKSSIYPDQRELILPRGTEYVIRSVEKLGDGSIKVNA
                     DVLMPGKD"
     gene            complement(3463..>5926)
                     /locus_tag="FZ103_RS19210"
                     /old_locus_tag="FZ103_19195"
     misc_feature    complement(4020..4022)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     assembly_gap    5927..6226
                     /estimated_length=300
                     /gap_type="within scaffold"
                     /linkage_evidence="align xgenus"
     gene            complement(<6227..7512)
                     /locus_tag="FZ103_RS24950"
                     /pseudo=""
     CDS             complement(<6227..7512)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FZ103_RS24950"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MISPEDVPIPPVDCDAVEKAGEKLKGDGDDVSQAGQDIKSSWQGL
                     QGIYSAPEQETLFAAIDPVATKGDDFDGAVTSVGTALINFANDVRPPGGGVLSEKVISP
                     EDVPIPPVDCDAVEKAGEKLKGDGDDVSQAGQDIKSSWQGLQGIYSAPEQETLFAAIDP
                     VATKGDDFDGAVTSVGTALINFANDVRPIKRRLQTLKADAESFQSKISGDEDWREDEDK
                     INELDSLNNDILQAVFEYQRAERECANTITALFGGTTFVATEPGEQGSLGANQVAHGTS
                     EALKDIETPWVTPQEHDAPWWEDVGNGIKDFGVGIAEDLGALVGLYGEGGWGVSSWSEW
                     GSNLKNNWGDTLNGLGSLVGFYGKDGWGVSSFGEWWGNFSSGWTEFAHAVVPWREWGDR
                     PGYVITQSVLNIGSMALGGAGVVKALANP"
     gene            7998..10256
                     /locus_tag="FZ103_RS19215"
                     /old_locus_tag="FZ103_19200"
     CDS             7998..10256
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017594229.1"
                     /locus_tag="FZ103_RS19215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19200"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_156003048.1"
                     /sec_met_domain="T1TS (E-value: 3.3e-80, bitscore: 262.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAFTLPDFYLSHPARINPHVERSRRHTVDWARRMGMLDTPAPRG
                     GLVWDEHDLAVMDYALLCAYTHPDCDGPTLDLITDWYVWVFFFDDHFLELFKYSGDLAG
                     AQAYLDGLERFMTAADGESPEPANPAEAGLRDLWQRTVPHRSDDWRQRFIRSTHNLMVE
                     SLWELDNINRNRVANPIEYIQMRRRVGGAPWSANLVEVAAGAEVPPEIVGSRPVTVLVD
                     TFADAVHLRNDLFSYQREVGEEGENSNAVLVFERFFGCSTQEAAELVNDLLTSRMLQFE
                     DTALIETPALLAEHGLPPDRQAAVAAFAKGLQDWQAGGHEWHARSSRYMNDGATARSGG
                     LSGPTGLGTSGGRPAFSSIGPGLRRRSRQHSQPLLPQTGSLECEPLYMPFPIRRSTHLD
                     DARAYAVGWARDMGMLASVPGAGTGAVWTEQEFIDLDLAYCASMIHADADPEQLHLSSD
                     WLAWGTYGDDAYPRWFGATRNLQAAKLQNERLALFMPLDSDEAVPEPANPIERGLADLW
                     RRTTAPWTPAARRRFRPVVETMTDSWLWELHNQAQNRVPDPVDYIEMRRRTFGSDMTIS
                     LARLAHDEEVPEGIYETRTLRELETAAQDYACFLNDLYSYQKEVEFEGEVHNLVLVVEN
                     FLDVGRETARDIVVDLARARMEQFEHILATGLEDLLDQWGLDDRARAVITGHAEGLKDW
                     MSGILEWHRSCLRYKEDYLRRKHAPDPRRGFSWGPTGLGTAAARIGRPPVAAGGGARS"
     gene            complement(10296..10637)
                     /locus_tag="FZ103_RS19220"
                     /old_locus_tag="FZ103_19205"
     CDS             complement(10296..10637)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040449.4"
                     /locus_tag="FZ103_RS19220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19205"
                     /product="DUF6507 family protein"
                     /protein_id="WP_156003049.1"
                     /transl_table=11
                     /translation="MSKWDIQVSEVNGVVQTVGSHVAGADGEGGLVAKIETFGTHIGEA
                     GTAAASGPIGTALEEFVGEYGTTLQEMVLKSGSCIKGCVDATTAYLNGNLQMASDAQGN
                     AGNIDDLDL"
     gene            complement(10668..11141)
                     /locus_tag="FZ103_RS19225"
                     /old_locus_tag="FZ103_19210"
     CDS             complement(10668..11141)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FZ103_RS19225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FZ103_19210"
                     /product="hypothetical protein"
                     /protein_id="WP_156003050.1"
                     /transl_table=11
                     /translation="MKFELVDPAEWPDDDGSAAPADPGAEEFDDPDLAESGGPAEDADS
                     DEAGEAEQDPQKRLQASTRRLSAQVKQDAALIRDSLSKLEQQVADLEAPVADSGHSAPP
                     PSSFRAERFSTDHAGFAPPASAAWGRAAGGGPPAGPTMEPGAPGIRPIFDDRR"
     gene            11327..11662
                     /locus_tag="FZ103_RS19230"
                     /old_locus_tag="FZ103_19215"
     CDS             11327..11662
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621223.1"
                     /locus_tag="FZ103_RS19230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19215"
                     /product="hypothetical protein"
                     /protein_id="WP_156003051.1"
                     /transl_table=11
                     /translation="MSRWDFGDQTLITLTRNTSGTGDELGTLITQLIDAAEPLAGRFNG
                     SGKAAFDSFKARADQITADLNAGLTNINQGQGGMQAAFSTGNQTMADDANKNMGAANFD
                     AAKFRTA"
     gene            11689..11991
                     /locus_tag="FZ103_RS19235"
                     /old_locus_tag="FZ103_19220"
     CDS             11689..11991
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615257.1"
                     /locus_tag="FZ103_RS19235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19220"
                     /product="pore-forming ESAT-6 family protein"
                     /protein_id="WP_156003052.1"
                     /transl_table=11
                     /translation="MSTGRNSYDIGASQEAQTNIHSIMTRLEGLIGEHQGDVTTAMSDF
                     IADGVDDEYSAKEQKWHDAANEVREIIRLVRETLETNDGTAQESLSKANAAVQGI"
     gene            12331..13416
                     /locus_tag="FZ103_RS19240"
                     /old_locus_tag="FZ103_19225"
     CDS             12331..13416
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615256.1"
                     /locus_tag="FZ103_RS19240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19225"
                     /product="TNT domain-containing protein"
                     /protein_id="WP_156003053.1"
                     /transl_table=11
                     /translation="MARDYDSQLLESVAVRRKRLREAVLFGPQRTRRLLDENIGKIITG
                     LVISAVACAGSVGWSFLQSQLSSQEEAAQAQEQAQAPPPAAPSAPVPADWVGGEVTMDM
                     LAAELDDAGVPPELYVLPGEPQPPAGTATSYYLVTENERGYSAGIVEYEQGRTGMDFPT
                     EDEAARWVYGELVLVDADPKALTAAAENKGRQKTEKAVREVRKQLREGTGGSVQYTLRP
                     GTLVDAFGQESGSLLFPDGQPFSERGLPEIARGTAPGDTSPAPSPQETGTSAPSAPAES
                     PEAQTGTEAATPAESYHRYRVIHPFKVDASLSPNEGANPGGGVRFTVEAGGFVQPPALP
                     SIRWLLSNGYLERVEVTRVPA"
     gene            13502..14827
                     /gene="eccD"
                     /locus_tag="FZ103_RS19245"
                     /old_locus_tag="FZ103_19230"
     CDS             13502..14827
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="eccD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014913391.1"
                     /locus_tag="FZ103_RS19245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19230"
                     /product="type VII secretion integral membrane protein
                     EccD"
                     /protein_id="WP_156003054.1"
                     /transl_table=11
                     /translation="MTSWSRVTLVGENRRVDAVLPAQEPIGALMPEVLRLLGDQVRNPA
                     LPVHLTTASGVHLDGDSTLADRGVSDGDVLRLVRVDEPVPAPVVHEVPDAVGDVLDGNL
                     GRWNPAAARWSATGAVTVLALAIGALLWTGTGGASGVLALSASAAALLGLGLTLAATWR
                     EPAGTALAIAGGALGGEALWLAAGVYGWPGWALWCGLAAIAGAVVIGLGLTTPLGRGGT
                     IGGAVTLALTAVWAGGSALGMPVSQVGAAVAIACVVVLSLVLRFAMAMSGLTALDDRRG
                     GGSAVARSDVMTALANAHRTMTIATVAAAVSAGVAGVGLAADLGGWTAALAGLLAIVIG
                     SRSRLFPLILQKAPLMAAALAIVVALAFAWVEQSAWALWPAIGGLLAVLLIPAVVLSSD
                     PADHTRARLRRIANRFEAVAVIVLIPVAIGSFGTYERLINTF"
     gene            14870..15778
                     /locus_tag="FZ103_RS19250"
                     /old_locus_tag="FZ103_19235"
     CDS             14870..15778
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622706.1"
                     /locus_tag="FZ103_RS19250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19235"
                     /product="hypothetical protein"
                     /protein_id="WP_156003055.1"
                     /transl_table=11
                     /translation="MHDSAEPSAGTAAARAARHGDSLLRRFGRGAVRPFRPPEDVLVPI
                     RLGRELQRPVTTGRRVVVSRPQGWAAESTVTALLALVFAHFRYDRVLALDLGPGNSGLG
                     PRLGVPASAAPGLAGGAIESDSFDDVATCLEPIGDGLWLLPGLQEEMAQGRLDANAYQG
                     SVLPLTRFFGLTVIDRAADMSDGLNRAAQASAHVHVLVVPSTREGAASIGRAFDWMTAN
                     GAESLPHRIVVVFTEQSRGQDPAFDFRGSAAILRGSGAEVFRLGFDRHLAEGTRIDPAR
                     VSAATHATATRIAAECLRRSL"
     misc_feature    complement(17881..17896)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.4"
                     /tool="antismash"
     misc_feature    18606..18621
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.9"
                     /tool="antismash"
     gene            18702..18917
                     /locus_tag="FZ103_RS19255"
                     /old_locus_tag="FZ103_19240"
     CDS             18702..18917
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FZ103_RS19255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FZ103_19240"
                     /product="hypothetical protein"
                     /protein_id="WP_156003056.1"
                     /transl_table=11
                     /translation="MSAVAGSAEARAFIEGTNPAPSSPARPAPGRPDSYERRLRELPGV
                     PVSLLPRALYKATGGRIRLGGRTRAG"
     gene            19276..20106
                     /locus_tag="FZ103_RS19260"
                     /old_locus_tag="FZ103_19245"
     CDS             19276..20106
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013130640.1"
                     /locus_tag="FZ103_RS19260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_19245"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_156003057.1"
                     /transl_table=11
                     /translation="MSTDPGQDGGHGVPTVPSAARLYDYYLGGKNNFAVDRELAAKIES
                     QVPEIKQMARANRRFLTRAVEYMARQGIDQFLDIGSGLPASDPVHEVARRHSPEARVVY
                     VDHDPVVRVHAEALLADRAEITGVIQADMRDPEGIFADPALTGRIDPDRPVGLLLVAML
                     HFLQDHEDPYGLLRRYLERLPAGSFVAISHVENETAPERAAALERFYASTSSPGQTRSR
                     AEIARFFEGLELVDPPGLAHGGDWTTDPSPVVDADDHIPPEQAWGLAGVARIPG"
ORIGIN
        1 cactcactcc aggagctcac accccagccg tcctcgccgt agaggcccac cagagcaccc
       61 aggtcctcgg cgatacccac accgaagtcc ttgatgccgt tgccgacgtc ctcccaccac
      121 ggcgcatcat gctcctgcgg cgtcacccac ggcgtctcga tgtccttcaa cgcctcactc
      181 gtgccgtgcg ccacctggtt ggcacccaag gagccctgct cacccggctc ggtggccacg
      241 aacgtcgtgc ccccgaacaa cgcggtgatc gtgttggcgc actcccgctc ggcccgctga
      301 tactcaaaca ccgcctgcag gatgtcgttg ttcagcgagt ccagctcatt gatcttgtcc
      361 tcgtcctcac gccagtcctc atcaccggag atcttggact ggaacgactc cgcatcggcc
      421 ttcagcgtct gcaaccgcct cttgatcggc cgcacatcgt tggcgaagtt gatcaacgcc
      481 gtgcccaccg aggtgaccgc cccgtcgaag tcgtcgccct tggtcgccac cggatcgatc
      541 gccgcaaaca gcgtctcctg ctccggagcc gagtagatcc cctgcagccc ctgccaggag
      601 gacttgatgt cctgacccgc ctgggacaca tcgtccccgt cgcccttgag cttctccccg
      661 gccttctcca ccgcatcgca atcgaccggg ggaatcggga cgtcctcggg actgatcacc
      721 ttctcactca aaacgccacc gccgggagga tcagggagtt ctacacaggc cttcccgatc
      781 taccacagcc gcctccggga cggccacccc atgagatcgt cgtctcatgg ataccgtgtc
      841 cggcgacttc gagctgacca tggacgaact acgggccgtg gcacgctacg tggcgcagag
      901 cgctgaagag gtcctccccg ttttcgaggt cgcccgtccc gacgacccgc ggccccgcgc
      961 ggccgtggcc gcggcatggg agttcgcgga cggcgcgcgc aggaccaggt tgcagcgcgt
     1021 cacctcgctg gatgcccatc gggcggccaa ggaggccccc accgaggcgg cgcgcctcgc
     1081 cgcgcgctgc gccggcgacg ccgcctccgc cgcctacctg catccactcg ccgatgcccg
     1141 ccaggtgggc cacatcctgc gcgcagccgc gagtgcggcg cgggtggcgg aactggaagc
     1201 gggcggcgat cccggcgtcg cagacagggc gatcgagcgt gctcggcagc gggcggcacc
     1261 ggtcctggtc gacgttctcc gccggtatcc ccccgcagcg acggccagga atcgcgtcgc
     1321 ggagctgatg agcaccctgg actcctcgct gcgcgcctga gccgcacaac ggggcgcgca
     1381 cggcgccggc acggccgtgt ccgcccgcac ccccgagtcc cccttcgcgc ggcgtccggg
     1441 gcctcgcccg cggcttcgcc ggtcagccgt cgtcgtgctc ggtcggcacc ggccgccacc
     1501 cgcccgaacc gtagacccag cgctgcccgc tgccgtcgag cgcctcatac accgcgccga
     1561 ggggcagctc ggcctcctca ccgttcgcgg cggccacccg cagcacgtcc acggccatcc
     1621 agtaggcata gtgcgccgcc tcggactccc actccgcggg ttcgagcgcg gcgcggtaat
     1681 gctccatctc tgcggctctc ctgcccgcgg ggaccagggg atccggcgaa gcccacggat
     1741 ccgcagcgga gcacgcccag tccagttgcc ggatgatgat ccaatcgggg cgtcccgaat
     1801 tggccagtac acgctcggca ccgcacaccg ggcacgggcc cggtttccgg ggggcgaagc
     1861 ggtagagcat ccagtgcagg tcgatgatgc tgtgctcgcg ggcgtccgcg ccgcggacca
     1921 ggccgctgga ggtccacggg cagccgcagt cgggacagcc cgtggccggc tcaccggggt
     1981 aagtcgactc ccgttcggtc cccggccagc cgggcggcca ccgggactcg caccggatgc
     2041 accgctgttg cgagcgcccc gggccgatcc gcaaggcgtt ggaggccacc tccccaccgc
     2101 ccatccggtc gcgcagcccg ccgaggtagc ccggatacgt cccgaactcc ttgggccagg
     2161 cgaagtaccc cgaatgcggc catagctgtt cgatgcagct catcaccgtg atggtgttcc
     2221 acggctcctc acggaagctg ccctcgtcgt tgaggagctc ggctatggtc tgggggtcgg
     2281 ccatcgtctc ggcactgagt tcggccagcc gccggatggg cgagggactg tgccggtcca
     2341 cacccagcga cgcgaattcc gcgatctcca acgccttcgc cacgaagcgg cgatgcgcct
     2401 cttcgcgctc ggcccacttg cgcttcgcct cctgctggtc cggactcccg tcgtaggggc
     2461 cgacatcggc actgccgcgg attcgtcgca ccatggaaca gcattctgct gggccgactc
     2521 acgacgtgcc aacggctgtg tcgggcgggg ccgccgcggg aacagccccg cggcggcgca
     2581 cccgatcagt cgcgggcgcg aatcctcaaa tcgtcgaggc tttcggcgcg ctgctccgcg
     2641 gcgtcggacg ggaggcggcc ggccttgggg tcctcctcgg cgccgatcca gctgcggagc
     2701 atctccgagg gcggcaggcc ctggctctcg gcctcacgca tccggtcgat ccaccgcctc
     2761 tcggcgcggt ggccgtcggc gcgggccttg gcacgcggaa cgaatccggc cgcgtcgtcg
     2821 gtctccgcca cccacaggta acccagcagc acatcgccgc ggtaggcggg caggtagcgc
     2881 accgccgaat cggtggccat cttatagccc gggccgttgg tcgtgaacgg ccccagcggg
     2941 ccccatccct tcgaccggtc cgtcggggtg ccgtccggga agaactcggg ttcgggcggg
     3001 gccggaggca ccggcggctc gctgtggtcc ggattcgcca gttgccgcag ctcctcatag
     3061 ctgcccagtt ccgcgaactc ggctcgtcgc ggaaccgcac ccgctatggg atgctcctcg
     3121 gcgccgatcc accgccgcag ggtctcctcg gcgggaagcc gcgcggcgta tccctcctcc
     3181 agtcgttccg accatactcg ggcggcctgg aagccggtct tgacgtcctg tgcactaagg
     3241 cggcggataa aggaagcccc gctggtacgc acgccggcat acaggtaccc gatcacctcg
     3301 ccaccgagtt ccaccggcag atagcgcacc ggtcccgaca ccttcgccga atagctcact
     3361 ccgggcgttc ctctgcggga tgcgcccccg ccgccggacg cgtttgccga tggcgcggaa
     3421 gctgcgggga acgcttcgct gtcgctgttc acaccgtcac ctctaatcct tgccaggcat
     3481 caggacgtcc gcattcacct tgatgctgcc gtcgccgagc ttctcgacgc tcctgatgac
     3541 gtactccgta ccccgcggga ggatgagttc ccgctggtcc gggtagatgc tgctcttgcc
     3601 catccacacg ccgggatggc cctcgggcac gttgaggtgg aacttgtact cgtagggatt
     3661 gttgtcgacc acggtcgggt tcttgccgag cgacgtcgac atgtaggcgt tgtcggactg
     3721 ggtctccccg atcatcttct tcagcgcctc ataggcgttc ggactgctgg ggtcgaagcc
     3781 cttcatgaag ctgaaatcgt ggaggccccg gaccacttcg acgtcttcgg gaagcgcggt
     3841 cctctggaag ccggcgtcca tgtccgcgat tcgctggtcg acctcttccg gcgtggggaa
     3901 cccgtcgaac gtctgaatca tccgcccacg gccgccggcg ctgtcgatcc actgttcgag
     3961 ccgcgcatcg gggttctccg actgcatgat gtcgttgacg atgatgcgct gttcttccgt
     4021 aaggtccttc tgattgtcga atgcgcgctc gacgtcggtc atgctgatac gcccatcgac
     4081 catgtccatg aggtgcatgc cggggccgac gctcttccac ttcatgtcga ggatctgctg
     4141 ggtggtcgcc tggccccgca gaatggggtt gagccaggac tggcgggtgt agtcctccag
     4201 tccttcacgc tgcgattcgg tcagcctctc gtaggtctcc gggcggagca cctcctcgcc
     4261 gtattgctcg cccgcgtcgt cggtgtcgaa gtggcggacg ccgtcctcgt cgacctggcc
     4321 cggccaggtg gagggatcgt tcgggtcgat gccgctgtcg gggtcggcgc ccggagtggt
     4381 gtcgccggcc ggggcgttgt tgtcgacgtt gtccaccggg tcggtgtcga ccggatcggt
     4441 gtcggcgggg tcggtgtctc cggtatccgc gtccaccgga tcggtgtccg ccgggtccgt
     4501 gtcgaccgga tcggtgtcca cggggtcggt ggtttcgccc aggtcgctgt tcggggcgtc
     4561 accgtcgggc gtgttgcccg gccgcgcggg atcggtgtcg accgggtcgg cgggggtctc
     4621 cgtgttgccg gcgtcctgct ggttgccgtt ctgttggccg tcgggcccgc cgttgccgtc
     4681 cagaccgccg aggggaccgc ttgggccgct cgggcctccc ggaccaccgg ggtcgctcgg
     4741 gtgaccgccg ctgccggggc cgtcagggct tccgccgccg gggccacccg atccgcccgg
     4801 gctgccaccg ccgttgccgg tggactggta ctggccgccg ttgccgttgt tgaacgccgg
     4861 atcgacgtcg accggatcgt tgccgccgcc caccggagtt gcgcggttct ccagggcctc
     4921 ggcgtcgtcc agggagttct gcaggccctg cagctggtcc tggtcgaggc tcatgtcgtc
     4981 gagctggttc tgcaggtcct gggtggactg ctgccccggg cggttgccga tctgctggag
     5041 cccctgcagc tggccgtcgg agggctggcc gttgctgtcg gtgtcgccgt tggtgtcgcc
     5101 cgaggtctcg gagccgtcgc cgccgacctt gcgggcgccc ttggccagcg ccttgaccac
     5161 gccggcacca cccagcgcca tactcccgat gttcagcacc gactgcgtga tcacataccc
     5221 cggccgatcc ccccactcgc gccagggcac caccgcgtgg gcgaactccg tccagcccga
     5281 ggagaagttg ccccaccact cgccgaagga gctcaccccc cagccgtcct tgccgtagaa
     5341 gccaacgagg ctgcccaggc cgttgagagt gtcgccccag ttgttcttga ggttgctgcc
     5401 ccactcactc caggagctca caccccagcc gccctcgccg tagaggccca ccagagcacc
     5461 caggtcctcg gcgataccca caccgaagtc cttgatgccg ttgccgacgt cctcccacca
     5521 cggcgcatca tgctcctgcg gcgtcaccca cggcgtctcg atgtccttca acgcctcact
     5581 cgtgccgtgc gccacctggt tggcacccaa ggagccctgc tcacccggct cggtggccac
     5641 gaacgtcgtg cccccgaaca acgcggtgat cgtgttggcg cactcccgct cggcccgctg
     5701 atactcaaac accgcctgca ggatgtcgtt gttcagcgag tccagctcat tgatcttgtc
     5761 ctcgtcctca cgccagtcct catcaccgga gatcttggac tggaacgact ccgcatcggc
     5821 cttcagcgtc tgcaaccgcc tcttgatcgg ccgcacatcg ttggcgaagt tgatcaacgc
     5881 cgtgcccacc gaggtgaccg ccccgtcgaa gtcgtcgccc ttggtcnnnn nnnnnnnnnn
     5941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncgcg ggttggccag
     6241 cgccttgacc acgccggcac cacccagcgc catactcccg atgttcagca ccgactgcgt
     6301 gatcacatac cccggccgat ccccccactc gcgccagggc accaccgcgt gggcgaactc
     6361 cgtccagccc gaggagaagt tgccccacca ctcgccgaag gagctcaccc cccagccgtc
     6421 cttgccgtag aagccaacga ggctgcccag gccgttgaga gtgtcgcccc agttgttctt
     6481 gaggttgctg ccccactcac tccaggagct cacaccccag ccgccctcgc cgtagaggcc
     6541 caccagagca cccaggtcct cggcgatacc cacaccgaag tccttgatgc cgttgccgac
     6601 gtcctcccac cacggcgcat catgctcctg cggcgtcacc cacggcgtct cgatgtcctt
     6661 caacgcctca ctcgtgccgt gcgccacctg gttggcaccc aaggagccct gctcacccgg
     6721 ctcggtggcc acgaacgtcg tgcccccgaa caacgcggtg atcgtgttgg cgcactcccg
     6781 ctcggcccgc tgatactcaa acaccgcctg caggatgtcg ttgttcagcg agtccagctc
     6841 attgatcttg tcctcgtcct cacgccagtc ctcatcaccg gagatcttgg actggaacga
     6901 ctccgcatcg gccttcagcg tctgcaaccg cctcttgatc ggccgcacat cgttggcgaa
     6961 gttgatcaac gccgtgccca ccgaggtgac cgccccgtcg aagtcgtcgc ccttggtcgc
     7021 caccggatcg atcgccgcaa acagcgtctc ctgctccgga gccgagtaga tcccctgcag
     7081 cccctgccag gaggacttga tgtcctgacc cgcctgggac acatcgtccc cgtcgccctt
     7141 gagcttctcc ccggccttct ccaccgcatc gcaatcgacc gggggaatcg ggacgtcctc
     7201 gggactgatc accttctcac tcaaaacgcc accgccgggc ggccgcacat cgttggcgaa
     7261 gttgatcaac gccgtgccca ccgaggtgac cgccccgtcg aagtcgtcgc ccttggtcgc
     7321 caccggatcg atcgccgcaa acagcgtctc ctgctccgga gccgagtaga tcccctgcag
     7381 cccctgccag gaggacttga tgtcctgacc cgcctgggac acatcgtccc cgtcgccctt
     7441 gagcttctcc ccggccttct ccaccgcatc gcaatcgacc gggggaatcg ggacgtcctc
     7501 gggactgatc accttctcac tcaaaacgcc accgccggaa ctcgcaggat gtctacacgc
     7561 acgcggacac gaccgcggga cagggggtcg tcagcaggat tccactcgct ccgcgtttcc
     7621 ccaagcgcac tgtccgtttc cggccagcgc acagacctga tcgcggccct ccgattcccg
     7681 tatcgcgcgg aaccgggcga ggcgcgcagc aggggcggac gatccgttcg ctcagcgccg
     7741 gaccggacgg ccgaccgcgt caccgctggc actctcactc tccgcttccg tcgcctacgg
     7801 ggtgcacttc cgatcggacg cacaccgccc gcgaaaagtt gcattgatcc cgcacttcgc
     7861 atatcaggct tcctccgccg ccacatccgc ctcaccggga gcgttcgcga atcgacacat
     7921 ccggccgata cagcgtgcga ccaatagaat tcgcagggta gagacacccc ggtcggtcga
     7981 tgagagtagg tacgcggatg aacgcgttca cactgcccga cttctatctg tcgcaccccg
     8041 ctcgcatcaa tccgcacgtc gagcggtccc gccggcacac ggtggactgg gcgcggcgca
     8101 tggggatgct ggacaccccc gcccccagag gcggcctcgt ctgggacgaa cacgacctcg
     8161 ccgtcatgga ctacgcgctg ctgtgcgctt acacccaccc cgactgcgac ggccccacgc
     8221 tcgacctgat caccgactgg tacgtctggg tgttcttctt cgacgaccac ttcctggagc
     8281 tgttcaaata ctccggcgac ctcgccggcg cccaggccta cctcgacgga ctcgaacgct
     8341 tcatgaccgc cgcggacggc gagtcccccg aacccgccaa ccccgccgaa gccggcctgc
     8401 gcgacctctg gcagcgcacg gtcccgcacc ggtccgacga ctggcggcag cgcttcatcc
     8461 gcagcaccca caacctgatg gtcgagtcgc tgtgggagct cgacaacatc aaccggaacc
     8521 gggtggccaa cccgatcgag tacatccaga tgcgccgccg ggtcgggggc gctccgtggt
     8581 cggccaacct ggtcgaggtc gccgcgggcg ccgaggtccc gccggagatc gtcggctcgc
     8641 ggcccgtcac cgtgctcgtc gacaccttcg ccgacgccgt gcacctgcgc aacgacctgt
     8701 tctcctacca gcgcgaggtc ggcgaggagg gcgagaactc caacgccgtg ctcgtcttcg
     8761 agcggttctt cggctgctcc acccaggagg ccgccgaact cgtcaacgac ctgctcacct
     8821 cgcgcatgct gcagttcgag gacaccgcac tgatcgagac gcccgcgctg ctggccgaac
     8881 acggcctgcc gccggaccgg caggcagccg tggccgcgtt cgccaagggc ctgcaggact
     8941 ggcaggccgg cgggcacgag tggcacgcgc gctccagccg gtacatgaac gacggcgcca
     9001 ccgcgcgctc gggcgggctc agcggcccga ccggcctggg cacctcgggc ggccgtccgg
     9061 ccttctcctc gatcgggccg ggcctgcgcc gcaggtcccg ccagcactcc cagcccctgc
     9121 tgccgcagac tggcagtctg gagtgcgaac cgctgtacat gcccttcccg atccgccgca
     9181 gcacgcacct ggacgacgcg cgcgcctatg ccgtgggctg ggcccgcgac atgggcatgc
     9241 tcgcatccgt ccccggggcc ggcaccggcg cggtctggac cgagcaggag ttcatcgatc
     9301 tcgacctcgc ctactgcgcg tcgatgatcc acgcagacgc cgaccccgag cagctccacc
     9361 tctccagcga ctggctggcc tggggcacct acggcgacga cgcctacccc cggtggttcg
     9421 gcgccacccg caacctccag gccgcgaagc tgcagaacga gcggctcgcg ctgttcatgc
     9481 cgctggactc cgacgaggcc gtccccgagc ccgccaaccc gatcgaacgc ggcctggccg
     9541 acctgtggcg ccgcaccacc gcgccctgga cccccgccgc acgccgccgg ttccgccccg
     9601 tggtggagac catgaccgac agctggctgt gggagctgca caaccaggcg cagaaccggg
     9661 tgcccgaccc cgtcgactac atcgagatgc gccgccgcac cttcggctcg gacatgacca
     9721 tcagcctggc gcggctcgcg cacgacgagg aggtccccga ggggatctac gagacgcgca
     9781 cgctgcgcga actcgaaacc gccgcgcagg actacgcctg cttcctgaac gatctgtact
     9841 cctatcagaa ggaggtcgag ttcgagggag aggtccacaa cctggtcctg gtggtcgaga
     9901 acttcctcga cgtcggccgc gagaccgcgc gcgacatcgt cgtcgacctc gcgcgcgccc
     9961 gcatggagca gttcgaacac atcctcgcca ccgggctcga ggaccttctc gaccagtggg
    10021 gcctcgacga ccgcgcccgc gccgtcatca ccggccacgc cgaaggcctc aaggactgga
    10081 tgtcgggaat cctggagtgg caccggtcgt gcctgcggta caaagaggac tacctgcggc
    10141 gcaagcacgc ccccgacccc cggcgggggt tctcctgggg acccaccggg ctgggtaccg
    10201 ctgcggcccg catcgggcgg ccgccggtcg ccgcgggggg cggcgcgcgc agctgatccg
    10261 cgtccgcggg ccggccgcgc ggcgcggccg gcccgtcaga ggtcgaggtc gtcgatgttg
    10321 ccggcgttgc cctgggcgtc ggaggccatc tgcaggttgc cgttcaggta cgccgtcgtg
    10381 gcgtcgacgc agcccttgat gcagctgccg ctcttgagca ccatctcctg cagcgtggtg
    10441 ccgtactcgc cgacgaactc ctccagggcc gtgccgatgg ggccgctggc cgcggccgtg
    10501 ccggcctcgc cgatgtgggt tccgaacgtc tcgatcttgg cgaccaggcc cccttcgccg
    10561 tccgcgccgg cgacgtggga gccgaccgtc tgcacgaccc cgttgacctc agagacctga
    10621 atgtcccact tgctcatcgg ttccggttcc ctcctcctgc gcgggcctca acgccggtcg
    10681 tcgaagattg ggcgtatccc gggcgcgccc ggttccattg tcggcccagc cggcggcccg
    10741 ccgcccgccg cacggcccca tgcggccgat gccggcggtg cgaaaccggc gtgatcggtg
    10801 ctgaaccgct cggcgcggaa actggagggc gggggcgcgg aatggccgga atcggccacc
    10861 ggtgcttcga ggtcggcgac ctgctgctcc agcttggaca ggctgtctcg gatcagcgcg
    10921 gcgtcctgct tgacctgcgc actcagtcgc cgggtcgagg cctggagccg cttctggggg
    10981 tcctgctcgg cctcgcccgc ctcatcggaa tcggcgtcct cggccggacc gccggattcg
    11041 gccaggtcgg ggtcgtcgaa ttcctcggcg cccgggtcgg cgggcgccgc ggatccgtcg
    11101 tcatcgggcc attcagcggg atcgacgagt tcgaacttca tgcggtcgcc ccccacaggt
    11161 gcgcacgtaa ccgtccggtg cttcccactg ccgtcggcag gttcgaccaa tataatttag
    11221 cggcgattcc tcccgtttac cgtcgactcc ggatcgccgg aaccggtgac ccggcggagg
    11281 cgtccaaccg cggaagactg caggtaaccg aggagcaggt gaacagatgt cacgttggga
    11341 cttcggcgat cagaccctca tcaccctgac ccgcaacacc tcgggcacgg gcgacgagct
    11401 cggcaccctg atcacgcagc tgatcgacgc cgccgagccc ctggccggac ggttcaacgg
    11461 ctcgggcaag gcggccttcg actcgttcaa ggcgcgcgcg gaccagatca cggccgacct
    11521 caacgccggt ctgaccaaca tcaaccaggg tcagggcggg atgcaggccg cattttcgac
    11581 cggtaaccag accatggccg acgacgccaa caagaacatg ggcgccgcga acttcgacgc
    11641 cgccaagttc cgtacggcct gaccccaccg cggttgagga ggacccccat gtcgaccgga
    11701 cgcaacagct acgacatcgg cgcctcgcag gaggcgcaga ccaacatcca ctcgatcatg
    11761 acgcgcctgg aaggcctgat cggcgagcac cagggcgacg tgaccaccgc gatgtccgac
    11821 ttcatcgccg acggcgtcga cgatgagtac agcgccaagg agcagaagtg gcacgacgcc
    11881 gccaacgagg tgcgtgagat catccggctg gtgcgcgaga ccctggagac caacgacggc
    11941 accgctcagg agtccctgag caaggcgaac gccgccgtcc agggaatcta ggcggcgggc
    12001 gcggcgcctg cgaaccggtc ttccgccggg atcgccccgg ccgccggtcg gcggccccgc
    12061 gccgggcccg ccgcgctccg ctcgaaccgc cggcgggtcg gcgccccggg gcgtcggccg
    12121 ccgcccctct ctcccccgga tcgggcggcc gcgaacccgc cgctcgtcct ccgcggcgcc
    12181 ccgagcgccg cccgccccgc gctgtccgcg ggcccgcgaa cgccccgtac tctggcgggt
    12241 gacctcgctt cagcacgccc tgcggccgcc acacggcctg ccccagccgc cacggaccgt
    12301 atccgccgcc cgctttcgga aggaggcttg atggcccgcg actacgacag ccaactgctc
    12361 gaatcggtcg ccgtgcgccg caagcggctc cgggaggcgg tcctcttcgg tccccagcgc
    12421 acccgcagac tcctcgacga gaacatcggc aagatcatca ccgggctggt catctccgcc
    12481 gtcgcctgcg cgggcagcgt gggctggtcg ttcctgcaga gccagctcag cagccaggag
    12541 gaggccgccc aggcccagga acaggcccag gccccacctc cggccgcgcc gtcggccccc
    12601 gttcccgccg actgggtggg cggcgaggtc accatggaca tgctggccgc cgaactcgac
    12661 gacgccggcg tgccgcccga gctctacgtg ctgccgggcg aaccgcagcc gccggccggc
    12721 accgccacca gctactacct ggtgaccgag aacgagcgcg gctactccgc gggcatcgtc
    12781 gagtacgagc agggccgcac cggcatggac ttcccgaccg aggacgaagc ggcccgctgg
    12841 gtctacggcg aactcgtcct cgtcgacgcc gaccccaagg ccctgaccgc cgccgcggag
    12901 aacaaggggc ggcagaagac ggagaaggcc gttcgcgagg tccgcaagca gctccgcgag
    12961 ggcaccggcg gcagcgtcca gtacaccctg cggccgggca cgctcgtcga cgccttcggc
    13021 caggagagcg gctccctgct cttccccgac ggccagccct tcagcgagcg cgggctgccc
    13081 gagatcgcgc gcggcaccgc gccgggcgac accagccccg cgccgtcgcc gcaggagacc
    13141 ggcacctcgg cgccgtccgc gcccgccgag agccccgaag cccagaccgg gaccgaggcg
    13201 gccaccccgg ccgagagcta ccaccgatac cgtgtgatcc accccttcaa ggtcgacgcg
    13261 tcgctgtccc ccaacgaggg cgccaacccg ggcggaggcg tccggttcac cgtcgaggca
    13321 ggcgggttcg tccagccccc ggcgctgccg agcatccgct ggctgctgag caacggctac
    13381 ctcgaacggg tcgaggtgac ccgggtgccc gcctgacccc cggccgcgac cgcggcggcg
    13441 tcccccaccc cctgcgccga ccgggcaggg accgcagcga agaagtgatg ggaaaggctc
    13501 gatgacgtcc tggagccgcg tgacactcgt cggcgagaac cgccgggtcg acgccgtcct
    13561 gcctgctcag gagccgatcg gagcgctgat gcccgaggtg ctgaggctgc tgggcgacca
    13621 ggtgcgcaac cccgccctgc cggtgcacct gaccaccgcc tccggcgtgc acctcgacgg
    13681 cgactccacg ctggccgacc gcggcgtctc cgacggcgac gtgctgcgtc tggtccgcgt
    13741 cgacgagccc gtcccggcgc ccgtcgtcca cgaggtgccc gacgcggtgg gcgacgtcct
    13801 cgacggcaac ctcgggcggt ggaaccccgc cgccgcccgg tggagcgcca ccggtgccgt
    13861 caccgtactg gccctggcca tcggcgccct gctgtggacg ggcaccggcg gagcgtccgg
    13921 ggtcctcgcg ctgagcgcca gcgcggcggc gctgctcgga ctgggcttga cgctcgcggc
    13981 gacctggcgc gaacccgcgg gcaccgcgct cgcgatcgcc ggcggggcgc tgggcggaga
    14041 agcgctctgg ctggccgcgg gtgtctacgg ctggccgggc tgggcgctgt ggtgcgggct
    14101 ggcggccatc gccggcgccg tcgtgatcgg actggggctg acgactccgc tgggccgcgg
    14161 cgggaccatc ggcggcgccg tcacactggc gctgacggcg gtgtgggccg gcggttcggc
    14221 cctgggcatg ccggtctccc aggtgggcgc cgcggtcgcg atcgcatgcg tggtggtgct
    14281 cagcctggtc ctgcgcttcg ccatggccat gtccgggctg acggcgctgg acgaccggcg
    14341 cggcggcggc tcggcggtgg cgcgcagcga cgtcatgacg gcgctggcca acgcccaccg
    14401 cacgatgacg atcgccaccg tcgcggccgc cgtgtcggcg ggggtggccg gggtcgggct
    14461 ggccgcggac ctcggcgggt ggacggcggc gctggccggc ctgctggcga tcgtcatagg
    14521 cagccggtcg cggctgttcc ccctcatcct gcagaaggcg ccgctgatgg cggcggcgct
    14581 ggcgatcgtc gtcgcgctgg ccttcgcctg ggtcgagcag tcggcctggg cgctgtggcc
    14641 ggcgatcgga gggctgctgg cggtgctgct catcccggcc gtggtgctct cctccgaccc
    14701 ggccgaccac acccgggcgc ggctgcggcg catcgccaac cggttcgagg cggtggcggt
    14761 gatcgtgctg atcccggtgg cgatcgggtc gttcggcacc tacgaacgcc tcatcaacac
    14821 cttctgacgt cggatcccac cctcggcaca cgttcccgga ggccagacga tgcacgacag
    14881 cgcggaaccg tccgccggca cggccgccgc ccgcgccgcc aggcacggtg actcgctgct
    14941 gcgccggttc ggccgcgggg ccgtgcgccc gttccggccg ccggaggacg tgctggtgcc
    15001 gatccggctg gggcgggagc tgcagcggcc ggtgaccacc gggcgccgcg tcgtggtcag
    15061 ccggccgcag ggctgggcgg cggagagcac ggtgacggcg ctgctggcgc tggtcttcgc
    15121 gcacttccgc tacgaccggg tgctggcgct ggacctgggt ccgggcaaca gcgggctggg
    15181 gccacggctg ggggtgccgg cgtccgccgc gccggggctg gcggggggcg cgatcgagtc
    15241 ggactccttc gacgacgtgg cgacgtgcct ggagccgatc ggcgacgggc tgtggctgct
    15301 gcccgggttg caggaggaga tggcgcaggg gcggctggac gcgaacgcct accaggggtc
    15361 ggtgctgccg ctgacccggt tcttcgggct gacggtgatc gaccgcgccg ccgacatgtc
    15421 cgacgggctc aaccgggccg cgcaggccag tgcgcacgtc cacgtgctcg tggtgccctc
    15481 cacccgcgag ggcgcggcga gcatcggacg cgccttcgac tggatgaccg ccaacggcgc
    15541 cgagtcgctg ccgcaccgta tcgtcgtggt gttcaccgag cagtcgcgcg ggcaggatcc
    15601 cgccttcgac ttccggggat ccgcggcgat cctgcgcggg agcggggccg aggtgttccg
    15661 gctcggcttc gaccggcacc tcgccgaggg gacgcgcatc gacccggccc gcgtctccgc
    15721 cgccacacac gccacagcga cccggatcgc ggcggaatgt ctgcgccgat ccctgtgacg
    15781 gccgtgccgc ggtggggatc cgcggcggcc cgatccgtgt gacgatgact accggggcgc
    15841 gatgagtgcg ccgcgcccga accgacgccc gggagtgccc gacgatgctc gaccgaccgc
    15901 cgaacggaga gaacggggaa ccgcaggagc cggccccgaa cacaccggag gcaccacagg
    15961 acggcgcctc cccgtacgcg gacttcgacg cgcctccgcc gccctatgcc cggtacgggc
    16021 cgcaggagta ccggtccgag cagcggtcgg gaggtcaggc gccgccgtat ccggagcaca
    16081 ccggccgccc cggccgcggc cgccacgcgg cccaggggga tgcggcggac ggcaacccct
    16141 accgcctgcc ggggcgcggc gagcaggggg gccgcagcgc tgatcccgct cagcagcggc
    16201 ctggcagtgg gccgcagcgg ccgccggacg gcgggacatc ggggcagcag gggcagcagc
    16261 aggtcggcgg gacgcccgcg gcaggccgcc cggctcaccc tcaggcgagc ccgcagtggc
    16321 ccggcagcac ggctggatac gaggcgcccc ggcagtccgg ggcctccgcg gcccccaagc
    16381 cggaagacca gacgaccccg ctgaaccgct ccgccacccc ggcgcacccg gcggccggtc
    16441 cccagcagtc gggcaccgcc cgccccgcga ccggaccgca gcaggccggc agcacgcccg
    16501 gccccggctc ggcgagcccg gccaccgggg cccggcagca gagcggcaga accggcaacc
    16561 cccgtccggt caccggtccg cagcagccga ctgcgaacgc ggagggaggc acggggcgcc
    16621 ctggcaccgg tccccagcag tcgggggccg cccgccccgc aaccggaccg cagcaggccg
    16681 gcagcacggc ccatcccgga tcagcgaacc cggcttggga tacccaccag cccagcggcc
    16741 cgcaggggtc ccgcacccca taccccgcct ccgggccgca gcgatcccac gccccgcacc
    16801 ccgacaccgg ggggcaccgg ccgtccagtg gcacccagga caccagcacc gcgcggccgg
    16861 gcaccgcccg ccccgcgacc ggaccccagc aggccgaggc accacgccct gacacgggcg
    16921 cacagtcgcc cggcagccca gcccgccccc acacatctca ggcctccgcc ggacctcagc
    16981 aggcgagcgg tacgcagggc gccacctccg cgcggccggc caccggtccc cagcagtcgg
    17041 gcaccgcccg acctgcgacc gggccccggc aatcggccac cgacccggca accggcaccg
    17101 cgcagtccgg taccggttcc gcgcagcaca gcggtacgca ggacaccccc gcccggccgg
    17161 ccaccggtcc gcagcagccc cggtcccccc gcccgaacac ggggccgcag caggtggcgg
    17221 gttccgccga ttccggggag ccgaatccgg aggacgagac gacgccgctg cggcgttcgt
    17281 cgactccgga gaagtccggt cccgcccggc ctgcgaccgg gcgccaggct cacagcggcg
    17341 cttcggggac gggctcggcg cagggcgttt ccggaccgca gcatcccggc acgaccgcgg
    17401 ccggctccgg cccggcgcgc ccgagtaccg gtcggcaagg gccgggcggc ggcgagcagc
    17461 ccgatcggct cggggaaccc gaggctgccg agcagaccgt gctcctgccg cccgtcgacg
    17521 catcggcgcc acccgcgacc ccgcgcccca ccgccgagtc ctggggcggg caagccggtc
    17581 cgccggaatc tgacgctcgg cgcccggcga ccgggcctca ggcgtccggg gcgaccccgc
    17641 aggcaccggg cacagaccag gggcggcccc cgcaggaatc agtgacggcg cgcccggcaa
    17701 ccggaccgca gtcgtcaaac cccccatcgg gaaccggccc gcgccaaccg caagcagcgc
    17761 ggccggcaac tggaccgcag ggctcgcccg gcgcccccgg atcgcgcgcc ggttacccgg
    17821 cgaccggttc tccacagccg ggtgcagggg ccgctccgca ggcggaggag cccaagccgg
    17881 aagagcagac cgtcaacctg cagcgcatcg acgcttcggc caccgacacg gccgggcctc
    17941 ccctgccctc ggtccgaccg cgccgggtag gcggttcggg acgtgccgag caggcggacc
    18001 ggtcggccca ggagcattct gagcgatcgc ggtacgagcc ggaccggaaa gctccggagg
    18061 gagaccggcg ttccgccggg acccgatggc cggggcaggc gcccgggtcg tctccgacgg
    18121 gtccgggcgg aggcgcagcg cagcccggcc gggaccgccc ggcgcccggg ccgcagcaga
    18181 ccgccggacc ggaacaggac cgtgagcggc aggccgctca cggagcggag ggataccggc
    18241 gtccccagcc cgaggggcag gcgggaaccc gggaacaggc ggctcagccg cgcccggcga
    18301 ccggaccgca gcggccggag gtgcgtcccg ataccggtcc ccagcaagcc ggtacggcct
    18361 atcatccgcc ggccgatccg tccgcaggcg ctgcggaccg gaccgcgcaa ccgggtgaga
    18421 cggcgcggca ggcgcccgct tcggggccgc aggccgcgtt ccggcaacag gcgcccgcct
    18481 cggggccgca ggcggcgttc cggcagcaga ctccctccgc gggttcgccg tcgccgcacg
    18541 agcggccgcc gtcgtcggcg ccttcggccg gataccccgc cgcaagcgcc gcctccgctc
    18601 aggcgccgcc gggagcggac actgcgctgt cccacgtcgc gccggttccg cccgccgagc
    18661 acccgtccgg gccgcaggcc ggctacgcgg ccgggcactc ggtgtctgcc gtcgcgggct
    18721 ccgcggaggc tcgggccttc atcgagggga cgaaccctgc tccgtcctcg ccggcgcgcc
    18781 ccgcgcccgg tcggcccgac tcctacgagc gccgtctgcg cgagctgccc ggagtccccg
    18841 tctcgctgct gcccagggct ctctacaagg cgaccggcgg caggatccgc ctgggcggcc
    18901 gcacacgcgc cgggtagccg gggagcaccg gccgcggcgg gcgaccagcg gggcgcccgg
    18961 attacaggat gccggtgcgc cgcgccagag cgcgggcgcg tccacaaccg gcccgcgccc
    19021 gcagaggccc gttccgcgcc gacgggcgtg ccggcacatg ggcacgtccg tgagcgatgc
    19081 ttccgcgctg aagtggtgga actgcggcac ggtgaaccgc gcgcggcgcc ggacaggacc
    19141 cccgcgcccc gcgggggtcc tgtccggcgc atgcgcgcca gtcgtaatcc cgaacatcga
    19201 gggtgacgaa gcagcacccg tgtcgggcaa aatgtgctgt ctcacggcca atcgcgttct
    19261 gaggagacgg ccccgatgag caccgatccc ggtcaggacg gggggcacgg cgtcccgacc
    19321 gtgcccagcg cggcccgcct ctacgactac tacctcggcg gcaagaacaa cttcgcagtg
    19381 gaccgcgagc tcgcggcgaa gatcgagtcg caggtccccg agatcaagca gatggcgcgc
    19441 gcgaaccggc ggttcctcac tcgcgcggtg gagtacatgg cccgccaagg gatcgatcag
    19501 ttcctggaca tcggctccgg cctgcccgcg tcggacccgg tccacgaggt cgcgcgccgg
    19561 cacagtcccg aggcacgcgt ggtctacgtc gaccacgacc ccgtggtgcg ggtccacgcc
    19621 gaggcgctgc tggcggaccg ggccgaaatc acgggcgtca tccaggcgga catgcgcgat
    19681 ccggagggca tcttcgccga cccggcgctc accggccgca tcgaccccga ccgcccggtc
    19741 gggctgctgc tcgtcgcgat gctgcacttc ctgcaggacc acgaggatcc ctacggcctg
    19801 cttcggcgct acctggagcg gctgccggcc ggctccttcg tggccatcag ccacgtcgag
    19861 aacgagacgg cccccgaacg cgccgccgcc ctggagcggt tctacgcgag caccagctca
    19921 ccaggccaga cccgctcccg cgcggagatc gcccgcttct tcgagggcct ggaactcgtc
    19981 gacccgcccg gcctcgccca cggcggcgac tggaccaccg acccctcgcc cgtcgtcgac
    20041 gccgacgacc acatcccgcc ggaacaggcc tggggcctgg ccggagtggc ccggatcccc
    20101 gggtagtcct taccggaggc gggattggcc gggctcggcg cggccgtccc tcgggacgtt
    20161 ctcggcgacg aacccggccc tgcggataag agcggcgggc gggcggctcg gcgcctcgcc
    20221 ccgcgtgctg cggcggacga gagccggcgg cccccg
//
