LOCUS       NZ_VTZW01000008        21071 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomonospora sp. PA3 scaffold5.1, whole genome shotgun sequence.
ACCESSION   NZ_VTZW01000008
VERSION     NZ_VTZW01000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomonospora sp. PA3
  ORGANISM  Streptomonospora sp. PA3
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Streptomonospora.
REFERENCE   1  (bases 1 to 559326)
  AUTHORS   Matroodi,S., Siitonen,V., Baral,B., Yamada,K., Akhgari,A. and
            Metsa-Ketela,M.
  TITLE     Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated
            Halophilic Streptomonospora sp. PA3
  JOURNAL   Front Microbiol 11, 1237 (2020)
   PUBMED   32582127
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 559326)
  AUTHORS   Matroodi,S., Siitonen,V., Baral,B., Yamada,K., Akhgari,A. and
            Metsae-Ketelae,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-2019) Department of Biochemistry, University of
            Turku, Turun Yliopisto, Turku 20014, Finland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2018
            Assembly Method                   :: a5-MiSeq v. MAY-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: GCA_000695235.1
            Genome Coverage                   :: 292.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009728995.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 10:59:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,000
            CDSs (total)                      :: 4,917
            Genes (coding)                    :: 4,877
            CDSs (with protein)               :: 4,877
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 8, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 16S)
            partial rRNAs                     :: 7, 10 (16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 40
            CDSs (without protein)            :: 40
            Pseudo Genes (ambiguous residues) :: 0 of 40
            Pseudo Genes (frameshifted)       :: 8 of 40
            Pseudo Genes (incomplete)         :: 35 of 40
            Pseudo Genes (internal stop)      :: 0 of 40
            Pseudo Genes (multiple problems)  :: 3 of 40
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:29:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 207289
            Orig. end                         :: 228360
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VTZW01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21071
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21071
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21071
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11071](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11071
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(344..358)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.1"
                     /tool="antismash"
     misc_feature    617..631
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(1102..1118)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.43"
                     /tool="antismash"
     misc_feature    complement(1923..1937)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    2464..2477
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(2835..4019)
                     /gene="carA"
                     /locus_tag="FZ103_RS06820"
                     /old_locus_tag="FZ103_06810"
     CDS             complement(2835..4019)
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="carA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017617044.1"
                     /locus_tag="FZ103_RS06820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06810"
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="WP_186355925.1"
                     /transl_table=11
                     /translation="MTPQAPTGGSVPAVLVLEDGRAFHGRSFGAQGETLGEIVFNTGMT
                     GYQETLTDPSYHRQIVVMTAPHIGNTGVNDDDPESGRIWVSGYVVREPARISSNWRSQR
                     TLEEELVRQNVVGIALDGTRALTRHLRDRGAMRAAISTVETDPERLRERVLASPQMAGA
                     DLAGEVTTTEPYTVRPPEGVPTRFRVAAVDLGIKAMTPQRLAERGCEVTVLPAGAGAEE
                     ILGLRPDGVFFSNGPGDPATADAPVAAMRAVLESRTPLFGICFGNQILGRALELGTFKL
                     PFGHRGVNQPVQDVHTGRVYITSHNHGFAVDAPTGGPFETPFGRAEVSHVDLNDGVVEG
                     LRLLDRPAFSVQYHPEAAAGPHDAAEHFDAFCDLMAASTDPSSSSGRPAEPAQS"
     gene            complement(4016..5314)
                     /locus_tag="FZ103_RS06825"
                     /old_locus_tag="FZ103_06815"
     CDS             complement(4016..5314)
                     /EC_number="3.5.2.3"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291502.1"
                     /locus_tag="FZ103_RS06825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06815"
                     /product="dihydroorotase"
                     /protein_id="WP_156000048.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 3.1e-15, bitscore:
                     51.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHSSAAYLIRGARIAGGDPADILIRDGAIAEIGTGLGAAGAAVV
                     EADGLIALPGLVDLHTHLREPGREDAETVASGTRAAAAGGYTAVHAMANTDPVADTAGV
                     VEQVWRLGRESGRCDVQPVGAVTRDLAGAQLAELGAMADSAAGVRVFSDDGHCVSDALL
                     MRRALEYVKAFDGVVAQHAQEPRLTENAQMNEGVVSDRLGLAGWPAVAEEAVIARDCLL
                     TEHVGSRLHVCHVSTKGSVQILRWAKSRGCDVTAEVTPHHLLLTDDLAESYDPVYKVNP
                     PLRTAEDVQALREGLADGTIDCVATDHAPHPAEAKETEWATAAMGMLGLETALSVVQHT
                     MVDTGLLDWAGLARRMSAEPARIGRLAGHGRPIAPGEPANVTLYDADTASDIDPAALAS
                     KSANTPFRGMRLPGSIQATFLRGVPTVLDGKIQ"
     gene            complement(5399..6307)
                     /locus_tag="FZ103_RS06830"
                     /old_locus_tag="FZ103_06820"
     CDS             complement(5399..6307)
                     /EC_number="2.1.3.2"
                     /GO_function="GO:0004070 - aspartate carbamoyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016597 - amino acid binding [Evidence
                     IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014913461.1"
                     /locus_tag="FZ103_RS06830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06820"
                     /product="aspartate carbamoyltransferase catalytic subunit"
                     /protein_id="WP_155999702.1"
                     /transl_table=11
                     /translation="MRHLLSAGDLTRDEALLVLDTAAELAQVSGRSVKKLPTLRGRTVV
                     NLFYEDSTRTRTSFELAAKRLSADVVNFSAKGSSVSKGESLKDTALTLQAMGADGVVVR
                     HSASGAAHRLAEWVDGSVLNAGDGTHEHPTQALLDVYTMRERLGRLDGLRVAIVGDVLH
                     SRVARSNVLLLHTLGAEVTLVAPPTLVPVSVHTWPCSVSYDLDAVLPKSDVVMLLRVQA
                     ERMHDAFFPTAREYSRRYGLDGERFARMQDDAIVMHPGPMVRGMEISAEVADSARSTVN
                     EQVANGVSVRMAVLYLLLGGS"
     gene            complement(6307..6951)
                     /gene="pyrR"
                     /locus_tag="FZ103_RS06835"
                     /old_locus_tag="FZ103_06825"
     CDS             complement(6307..6951)
                     /EC_number="2.4.2.9"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017617047.1"
                     /locus_tag="FZ103_RS06835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06825"
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="WP_186355926.1"
                     /transl_table=11
                     /translation="MCAQSRAERDSDAPGGSAAERVPEPARTVLDGPEMQRALTRIAHE
                     VLERTKGGADVTLLGIPSRGVPLAARLAERIERVEGRTVPQGSLDITMYRDDLRLAPAR
                     ALGRTEIPPEGVDGRLVVLVDDVLFSGRTVRAALDALNDIGRPRAVQLAILVDRGHREL
                     PIRADYVGKNLPTSLRETVTVQLSEYDGTDAVLLGPAKPRAGAESPAAEEA"
     misc_feature    7068..7083
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    7088..7105
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.18"
                     /tool="antismash"
     misc_feature    complement(7227..7241)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.67"
                     /tool="antismash"
     misc_feature    7228..7242
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.2"
                     /tool="antismash"
     gene            7473..7967
                     /locus_tag="FZ103_RS06840"
                     /old_locus_tag="FZ103_06830"
     CDS             7473..7967
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622275.1"
                     /locus_tag="FZ103_RS06840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06830"
                     /product="transcriptional regulator"
                     /protein_id="WP_155999704.1"
                     /transl_table=11
                     /translation="MPSEYAKSLGARLRAIRTQQGLSLHGVEEKSHGRWKAVVVGSYER
                     GDRAVTVQKLAELADFYGVPMSELLPGGAAPAPLGPTPKLVIDLERMQQLPQEKAGPLA
                     RYVATIQSQRGDYNGRVLSIRQEDLRSLAVIYDRSPGDLTEELINWGVLDPEARRAVDA
                     F"
     misc_feature    8350..8365
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.94"
                     /tool="antismash"
     gene            8443..9057
                     /locus_tag="FZ103_RS06845"
                     /old_locus_tag="FZ103_06835"
     CDS             8443..9057
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622276.1"
                     /locus_tag="FZ103_RS06845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06835"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_343233417.1"
                     /transl_table=11
                     /translation="MQTTDIELWELAAPAFLHALPALLEIYTAAMDPPPEQIPGRHSIM
                     REHARQPRFRSVVALPRSGTGAAGFAYGFHGSGGQWWHDVVTAELRERDPGADRRWFAD
                     SFEVAELHVHPAQQGRGIGRGLLEAVTAARKERTAVLSTPTGRTAARGLYRSCGFVDVL
                     PEFHFPGSPHRPFTIMAAPLPLPGGGQRRPARRSPVWQWTG"
     gene            complement(8975..9928)
                     /gene="metF"
                     /locus_tag="FZ103_RS06850"
                     /old_locus_tag="FZ103_06840"
     CDS             complement(8975..9928)
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591131.1"
                     /locus_tag="FZ103_RS06850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06840"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_155999705.1"
                     /transl_table=11
                     /translation="MVGSTTRNGSAPAAAPRPRDIRELLKTGEPTFSFEFFPPKTDEGL
                     RKLWRVIRQIEALQPSFISVTYGAGGGTRDLTVEITEQVATDTTLLPVAHMTAVNHSVR
                     ELRHLIGRFAGVGVGNFLALRGDPPGDPLGEWVKHPEGLEYAEDLVRLLKETGDFSVGV
                     AAFPYKHPRSPDIESDTKYLVQKCRAGADYAVTQMFFDPEDYLRLRDRVAAAGCETPII
                     PEIMPVVKYSTIDMSEQLSGAPFPRHLAAEFDKVKDDPEAVRKLGIEQAQRMCERLLDE
                     GAPGIHFITFNQSTATREIYEQVAADRLPAMAGARP"
     misc_feature    complement(9921..9936)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.34"
                     /tool="antismash"
     gene            10001..11071
                     /locus_tag="FZ103_RS06855"
                     /old_locus_tag="FZ103_06845"
     CDS             10001..11071
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291498.1"
                     /locus_tag="FZ103_RS06855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06845"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_155999706.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.4e-42, bitscore:
                     140.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFSASSPISFVRTAVDGEIAGFVARRRAQLLEIGSELAPIVDAL
                     EAMLAGGKRLRPAFCYWGWRGAGGDDVPGIHAAAASLEFLQACALIHDDVIDNSDTRRG
                     LPATHKRLEALHERSGWSGSAEAFGRGAAILIGDLCLAWSEDLYQSSGLGLEALRAGRT
                     PFDAMRTEVMAGQYLDMLEQVREGGGVEATLRVMHYKAAKYTVERPLHLGAALAGRYGD
                     LAPVYTAYGLPLGVAFQLRDDILGVFGDPEQTGKPAGDDLREGKRTLIVAETLERAGAA
                     DRAEFLRRLGDPALGAEQVEWMRGVAEDCGALAACERRIDDYAAQATAALETGRLDDTA
                     RSPLADLVVAATARKH"
     gene            11226..12500
                     /locus_tag="FZ103_RS25990"
                     /old_locus_tag="FZ103_06850"
     CDS             11226..12500
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017592896.1"
                     /locus_tag="FZ103_RS25990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06850"
                     /product="DUF418 domain-containing protein"
                     /protein_id="WP_343233418.1"
                     /transl_table=11
                     /translation="MDPTPAPARGPVRPGERAPGPDLARGFMLLLIALANTPWYLYTAD
                     QAATGAHPADGSAADRVVQFAMLTAVDGRVYPMFACLFGYGLIRIYDRQRDAGASAREA
                     AAVVRRRNLWLLVFGFAHAALLFFGDILGAYGLIGLVAGRLLLRRGEAAMRVTASVLIG
                     LVMALWLMCILGAVVAASAPAVRGGQAAMAIPGFLRSSFSEPGYVDAMADRIAGWALMA
                     PLQALSLVLPAMVVLGMLIGRRRVLERTDRYRGVLIWTAAGGIGLAWASGLPEALVHVG
                     LVEVSGPVASALGGVRQLSGVFGGAGYVALFGLVGGALARRARMGAGAAAVAAVGKRSL
                     SCYLAQSVICAPLLAAWGLGLGAHLGSATMALFAAGVWLVTLAGAYALERAGRRGPAEV
                     LLRRLSYRSAAGRGGEGSGAEAPAR"
     gene            complement(12538..14163)
                     /locus_tag="FZ103_RS06865"
                     /old_locus_tag="FZ103_06855"
     CDS             complement(12538..14163)
                     /NRPS_PKS="Domain: AMP-binding (30-435). E-value: 6.5e-88.
                     Score: 287.0. Matches aSDomain:
                     nrpspksdomains_FZ103_RS06865_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622286.1"
                     /locus_tag="FZ103_RS06865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06855"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_155999707.1"
                     /sec_met_domain="AMP-binding (E-value: 7.5e-102, bitscore:
                     335.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTMQDVPLSVGNLVRYGVSVHSRARITTWTGGEPRRATLGEVG
                     ARAARLAHALRDLGVTGDQRVATFQWNNQEHLEAYLAVPAMGAVLHTLNIRLHADQVAY
                     IADHAEDHAVIVDASLLPLFAPILPRLRTVRHVIVAGGDPGDLAAEGVAVHAYEDLIAG
                     RPETFDWPETDERDAAAMCYTSGTTGAPKGVAYSHRSIYLHSMQGCMTDGEALAQSDTA
                     LAVVPMFHAMSWGLPYSALLVGASLLLPDRFLQPGPIADMIEAERPTVAAAVPTIWQGL
                     LEELESSPRDLSSLHSVVVGGSACPPALMQRFEERYGIPLLHAWGMTETSPVGSVARPP
                     AGSSGDERWAYRLSQGRLLAPVQGRLIGPGGEPVPHDGTSVGELEVRGPWVTGSYYGDE
                     DPEKFHDGWLRTGDVGTLTPDGFLRLTDRAKDVIKSGGEWISSVELENAVMAHPAVAEA
                     AVVAVPDPKWDERPMVAVVLKEGATAEAAELRAFLADRLARWQLPEFWAFVDEVPKTSV
                     GKFDKKTLRSKQSAGDLKVVEVRG"
     aSDomain        complement(12859..14073)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FZ103_RS06865_AMP-binding.1"
                     /evalue="6.50E-88"
                     /label="FZ103_RS06865_AMP-binding.1"
                     /locus_tag="FZ103_RS06865"
                     /protein_end="435"
                     /protein_start="30"
                     /score="287.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="WTGGEPRRATLGEVGARAARLAHALRDLGVTGDQRVATFQWNNQE
                     HLEAYLAVPAMGAVLHTLNIRLHADQVAYIADHAEDHAVIVDASLLPLFAPILPRLRTV
                     RHVIVAGGDPGDLAAEGVAVHAYEDLIAGRPETFDWPETDERDAAAMCYTSGTTGAPKG
                     VAYSHRSIYLHSMQGCMTDGEALAQSDTALAVVPMFHAMSWGLPYSALLVGASLLLPDR
                     FLQPGPIADMIEAERPTVAAAVPTIWQGLLEELESSPRDLSSLHSVVVGGSACPPALMQ
                     RFEERYGIPLLHAWGMTETSPVGSVARPPAGSSGDERWAYRLSQGRLLAPVQGRLIGPG
                     GEPVPHDGTSVGELEVRGPWVTGSYYGDEDPEKFHDGWLRTGDVGTLTPDGFLRLTDRA
                     KDVIKS"
     CDS_motif       complement(13570..13626)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FZ103_RS06865_0001"
                     /evalue="1.00E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="FZ103_RS06865"
                     /protein_end="198"
                     /protein_start="179"
                     /score="21.3"
                     /tool="antismash"
                     /translation="AMCYTSGTTGAPKGVAYSH"
     gene            complement(14312..14962)
                     /gene="thiE"
                     /locus_tag="FZ103_RS06870"
                     /old_locus_tag="FZ103_06860"
     CDS             complement(14312..14962)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591126.1"
                     /locus_tag="FZ103_RS06870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06860"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_186355927.1"
                     /transl_table=11
                     /translation="MNASLRERLDRARLYLCTDARAEQGDLAEFLDAALAGGVDIVQLR
                     DKSLEARQELAALETVRAACERHGALMSVNDRADIALAAGADVLHLGQNDLPVRHARSV
                     VGPGPLIGRSNSDAAMAAASAEEEGVDYFCVGPTWTTPTKPGRPAAGLELVERTAAMAP
                     ERPWFAIGGIDLANLDRVLAAGARRVVVVRAITRADDPRAAAAEFQRRLAAAD"
     gene            complement(15042..15401)
                     /locus_tag="FZ103_RS06875"
                     /old_locus_tag="FZ103_06865"
     CDS             complement(15042..15401)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017617053.1"
                     /locus_tag="FZ103_RS06875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06865"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_186355928.1"
                     /transl_table=11
                     /translation="MNENDRDTDALVGEWMTLKDAAKALNVSPNRIKQFIADHKLLGVR
                     RDGELCIPAAFISGGDIVKGLPGTLTVLADSGFSTDEALQWMFTPDDTLPGAPIQALSE
                     NRGTEVRRRAQAMAF"
     misc_feature    complement(15451..15466)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.16"
                     /tool="antismash"
     regulatory      15515..15627
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(15584..15597)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            15625..16842
                     /gene="thiO"
                     /locus_tag="FZ103_RS06880"
                     /old_locus_tag="FZ103_06870"
     CDS             15625..16842
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622291.1"
                     /locus_tag="FZ103_RS06880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06870"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_186355929.1"
                     /sec_met_domain="DAO (E-value: 4.7e-63, bitscore: 208.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRANPSSQSPTDVVVVGAGLIGLVTAWRAACAGLSVTVVAEHLDG
                     AASTVAAGMLTPATEASFGEEALMRFGILSRDRYPAFVAELEEESGVSAGYRAEGTLQV
                     AFDSDDMARLGHLSELRARLGLTTERLTGRECRRLEPMLAPSVRGGYLAAEDHSVDPRA
                     LLGALRAAAERRGAVGVRDRVRRLVVEDGRARGVVLDSGGEISAGQVVLAAGVATPAVE
                     GVPEGVVPPLRPVKGQLLRLRMAEGEPPIVARTVRGLVKGSPVYLVPRGTGEIVLGATQ
                     EEQGFDTRLTAGGLWEVLRDAHELVPGVSELEVAETCVGLRPGSPDNEPLLGPTAVPGL
                     HLAAGHFRHGVLFTPATGDAMAEALTTGALPDYARRFAATRVADRIPAGAAGGGPIEGG
                     EQDQWT"
     gene            16833..17033
                     /gene="thiS"
                     /locus_tag="FZ103_RS06885"
                     /old_locus_tag="FZ103_06875"
     CDS             16833..17033
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565075.1"
                     /locus_tag="FZ103_RS06885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06875"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_186355930.1"
                     /transl_table=11
                     /translation="MDVIINGERRAVSPRTTVEEVVRSLTREPGGVAVALNDEVVPKAG
                     WATTEVGENDRIDVLTAVQGG"
     gene            17035..17865
                     /locus_tag="FZ103_RS06890"
                     /old_locus_tag="FZ103_06880"
     CDS             17035..17865
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017617057.1"
                     /locus_tag="FZ103_RS06890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06880"
                     /product="thiazole synthase"
                     /protein_id="WP_155999708.1"
                     /transl_table=11
                     /translation="MTSTHSPALPDSPAEPAGAPRQAAGGDPLVIAGRSFTSRLITGTG
                     GAPSLRILEDALVASGTELTTVALRRVSPDAEGSVWDLLRRNGIRPLPNTAGCFTAGDA
                     LRTARLAREALETDWIKLEVVADDRTLLPDPVELLDAAERLVDEGFTVLPYTNDDPVLA
                     RRLEQVGCAAVMPLGAPIGSGLGIRNPHNIELIVEQAGVPVVIDAGIGTASEAALAMEL
                     GCDAVMLATAVTRAQDPVLMARAMRDAVAAGRAARRAGRIPVRRYAQASSPAVD"
     misc_feature    complement(18052..18065)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.91"
                     /tool="antismash"
     gene            18219..20174
                     /gene="pknB"
                     /locus_tag="FZ103_RS06895"
                     /old_locus_tag="FZ103_06885"
     CDS             18219..20174
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573837.1"
                     /locus_tag="FZ103_RS06895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06885"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_186355931.1"
                     /sec_met_domain="Pkinase (E-value: 1.1e-52, bitscore:
                     173.8, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 4.8e-07, bitscore: 24.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDMTTADPLVGTTLDQRYHVEARVASGGMATVYVAHDRRLDRRLA
                     CKVMHPSLAQDPSFVRRFINEAHSVAKLSHPNVVQVYDQGTDQGHVYLAMEYVPGQTLR
                     DMLNARGRLAPADALEVISPVLAALGAAHQAGLVHRDVKPENVLLTEDGRVKVADFGLA
                     RAVESAQQGTTKTGTVMGTAAYLAPEQIERGAADARTDVYAAGIMLYELLTGSQPHTGD
                     TPISIAYQHVNEDVPRPSRAVPGLPPQVDTLVTRATERDPRYRPGDAGQYLALVLNVKS
                     ALPAGAAAGPTAGPQAIGAAPAGGDGNDTLVVETGGLPDAAPVEPDYGDRGRNRRLDLD
                     YRSLPVIVVAGVLAVLMLGFGWWFLVGRYEPVPDVVGMHQQDARAVLGDIPVQVEVGDK
                     RVYSQEDPGSVAKVEPAVGERILPEDTVTVFLSKGPQTVEMPDLVGQSAQDARAALEDD
                     GFAEIVEEETTSQDHPAGTVISTDPEPGADADREAPVTLTVSEGFEVPDVEGLQQDQAQ
                     STLQEAGLQVSVTEQPSEDVPEGEVISQDPAAGGTVSSGDSVTITVSSGPEEIEIPDVT
                     GWKVDDAKKHLEELGFKVKVSRLFGGDRVTRYSPQGSATEGTEIELIASPFAPQGGDDG
                     GGGGRPGNGNGNGNDD"
     gene            20212..20916
                     /locus_tag="FZ103_RS06900"
                     /old_locus_tag="FZ103_06890"
     CDS             20212..20916
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654830.1"
                     /locus_tag="FZ103_RS06900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FZ103_06890"
                     /product="response regulator transcription factor"
                     /protein_id="WP_155999709.1"
                     /transl_table=11
                     /translation="MAEQPPAGGSAAAPPQRPIRVMVVDDHPMWRDAVARDLAEAGLEV
                     VATAGDGAKAVRVAPAARPTVAVLDLQLPDIGGVEVTRRLLEGADPPRVLVLSASGEQT
                     DVLEAVKAGATGYLVKSAGREELLEAVRRVHDGEAVYTPGLAGLVLGEYRRMAAEPRPG
                     RDPAAPSLTPRETEVLRLVAKGLGYKQIAERLTLSHRTVQNHVQNTLSKLHLHNRVELA
                     RYAIDRGLDGDE"
ORIGIN
        1 gcgtaggcgg cgccgaagtc ggcgtccagg cccatcacct cgccggtgga gcgcatctcc
       61 gggcccagca cggtgtccac gccctcgccc tggcggtcga tgaaccggtt gaagggcagc
      121 accgcctcct tgaccgacac gggggcgtcc atgggcaggg tgccgccgtc gccctcggcg
      181 ggcagcagcc cctcggcccg cagttcgcgc acgctcgcgc ccagcatcac ccgcgcggcg
      241 gccttggcca gcggcaccgc ggtcgccttg gagacgaagg gcgcggtgcg cgaggcgcgc
      301 ggattggcct ccagcacgta cagcaccccc gaggccaggg cgtactgcac attgagcagc
      361 ccgcgcacgc ccgtgccgcg ggcgatggcc tcggtggagt agcggatgcg ctcgaagtcc
      421 tccttgccca gcgtcaccgc cggcagcgcg caggcggagt cgccggagtg gatgccggcc
      481 tcctcgatgt gctccatgat gccgccgagg tagaggtcgg tgccgtcgta gatggcgtcg
      541 acgtcgatct cgatggcgtc gtcgaggaac cggtcgatca gcacggggta gtcggggctg
      601 acctcggcgt tgcgctcgat gtagtcggcc agcatgcgct cgtcgtagac gatctccatg
      661 ccgcgcccgc ccagcacgta ggagggccgc accatcaccg ggtagccgat ctcggcggcg
      721 acctcgcggg cgccggcgaa ggagtgggcg gtgccgtgct tgggcgcggg caggcccgcg
      781 tcggccagca ccttgccgaa ctcgccgcgg tcctcggcca ggtcgatggc ctcggggctg
      841 gtgccgacga tgggcacacc ggcctccttg aggccgcgcg ccaggcccag cggggtctgc
      901 ccgccgagct ggacgaccac ccccaccagc tcgccggtgg cgcgctcggc gcgcaccacc
      961 tccagcacgt cctccagggt gagcggctcg aagtagaggc ggtcgctggt gtcgtagtcg
     1021 gtggagacgg tctcggggtt gcagttgacc atgaccgtct cgtagccggc ctccgacagg
     1081 gcgaaggcgg cgtgcacgca gctgtagtcg aactccacgc cctggccgat gcggttggga
     1141 cccgagccca ggatgatcac cttggggcgc tcgcccgggg ggacctcggt ctcctcgtcg
     1201 tagctggagt agaggtaggg cgtcttggcg gcgaactccg cggcgcaggt gtcgacggtc
     1261 aggtagaccg ggtggatgcc cagcgcatag cgcagttcgc gcaccacctc ctcggtcttg
     1321 ccggtgatct cgccgatctg ggcgtcggag aagcccaggc gcttggcgcc gcgcagccgc
     1381 cgggtgtcca gccggccctg cgcgaggtcg cgggcggtct cctccagcag cagcatctgg
     1441 tccaggaacc aggggtcgat gccggtggcc tcgtggagct cggtgacgga ggcgccggcg
     1501 cgcagggcct gctggatgcg gcgcagccgc agctcgccgg gggtccgcac ggcctgcagc
     1561 agctcggcgg cgtcgccggg ctcgcccgcc caggtgaggc cgacgccgtt cttctccacc
     1621 gaccgcatgg ccttctgcag cgcctcgggg aaggagcggc cgatggccat ggcctcgccg
     1681 accgacttca tcgtggtggt cagggccggg tcggcgccgg ggaacttctc gaaggcgaac
     1741 cggggcacct tgaccacgac gtagtccagg ctcggctcga agctggccgg ggtctctgcg
     1801 gtgatgtcgt tggggatctc gtcgagggtg tagcccacgg ccagcttggc ggcgatcttg
     1861 gcgatgggga acccggtggc cttggaggcc agcgccgagg agcgcgagac gcgcgggttc
     1921 atctcgatga cgatgatgcg cccggtgccg gggtgcacgg cgaactggat gttgcagccg
     1981 ccggtgtcga cgccgacctc gcggatgacc gcgatgccga ggtcgcgcat gtgctggtat
     2041 tcgcggtcgg tcagcgtcat ggccggggcc acggtgatcg agtcgccggt gtgcacgccc
     2101 atcgggtcga agttctcgat ggagcagacg acgaccacgt tgtcgttgcc gtcgcgcatc
     2161 agctccagct cgtactcctt ccagccgagg atggactcct caagcaggac ctcggtgacg
     2221 ggcgaaagcg cgagcccctg gccggcgatg cggcgcagct ccttctcgtc gtgggcgaag
     2281 cccgagccgg acccgcccat ggtgaaggag gggcggacca ccaccgggta gttcagctcc
     2341 tcggcggcgt ccaggcactc ctggagggtg tggcagatgc gcgagcgggc ggactccccg
     2401 ccgatgcgct cgacgatgcc cttgaaggtc tcgcggtcct cgcccgactg gatggcctcg
     2461 acgttggcgc cgatcagctc gacgttgtac ttggccagca cgccggagtc gtgcagcgcg
     2521 acggcggtgt tgagcgcggt ctggccgccc agggtcggca gcagcgcgtc cgggcgctcc
     2581 ttggcgatga tcttctcgac catctccgcg gtgatcggct cgacgtaggt ggcgtcggcg
     2641 atctcgggat cggtcatgat cgtggccggg ttggagttca ccaggatgac gcgcaggccc
     2701 tcggccttga gcacgcggca ggcctgggtg ccggagtagt cgaactccgc ggcctgcccg
     2761 atcacgatcg gccccgagcc gaccacgagg acggacttca ggtcattacg gcgcggcatg
     2821 tgtggtcccc tggcttacga ctgtgcgggc tcggccggcc ggccggagct gctggacgga
     2881 tcggtggagg cggccatgag gtcgcagaag gcgtcgaagt gctcggcggc gtcgtgcggg
     2941 ccggcggcgg cctcggggtg gtactggacg ctgaaggcgg gccggtcgag cagccgcagg
     3001 ccctcgacca cgccgtcgtt gaggtcgacg tggctgacct cggcgcggcc gaagggggtc
     3061 tcgaaggggc cgccggtggg cgcgtcgacg gcgaagccgt ggttgtggct ggtgatgtag
     3121 acccgcccgg tgtgcacgtc ctggaccggc tggttcaccc cgcggtggcc gaacggcagc
     3181 ttgaaggtgc ccagctccag cgcgcggccc aggatctggt tgccgaagca gatgccgaac
     3241 agcggcgtgc gcgactccag cacggcgcgc atcgcggcca ccggcgcgtc ggcggtggcc
     3301 gggtcgccgg ggccgttgct gaagaacacg ccgtcggggc gcaggccgag gatctcctcg
     3361 gcgccggcgc cggccggcag gacggtgacc tcgcagccgc gctcggccag gcgctggggg
     3421 gtcatcgcct tgatgcccag gtccaccgcc gcgacgcgga agcgggtggg caccccttcg
     3481 ggcgggcgca cggtgtaggg ctctgtggtg gtgacctcgc cggccaggtc ggcgcccgcc
     3541 atctgcgggc tggccagcac ccgctcgcgc agccgctcgg ggtcggtctc gacggtgctg
     3601 atggcggcgc gcatggcccc gcggtcgcgc aggtggcggg tgagggcgcg ggtgccgtcc
     3661 agcgcgatgc ccaccacgtt ctggcgcacc agctcctcct ccagggtgcg ctgggagcgc
     3721 cagttggagg agatgcgggc gggctcgcgc accacgtagc ccgagaccca gatccgcccg
     3781 gattcggggt cgtcgtcgtt gacgccggtg ttgccgatgt gcggggcggt catcacgacg
     3841 atctggcggt ggtaggaggg gtcggtgagg gtctcctggt agccggtcat gccggtgttg
     3901 aagacgatct cgccgagggt ctcgccctgg gcgccgaagg acctgccgtg gaaggcgcgc
     3961 ccgtcttcga ggacgaggac ggcgggtacg gagccgccgg tcggtgcttg tggagtcact
     4021 ggatcttccc atcgaggacc gtggggacgc cgcgcaggaa cgtcgcctgg atgctgccgg
     4081 gcaggcgcat gccccggaag ggggtgttcg cgctcttgga ggccagggcc gccgggtcga
     4141 tgtccgaggc ggtgtccgcg tcgtacagcg taacgttggc gggctcgccg ggggcgatcg
     4201 ggcgcccgtg acctgcgagg cgcccgatgc gagccggttc ggccgacatc cgccgggcca
     4261 gtccggccca gtcgagcagg ccggtgtcga ccatggtgtg ctggacgacc gacagcgcgg
     4321 tctccagtcc gagcatgccc atcgcggccg tggcccactc ggtctccttg gcctcggcgg
     4381 ggtggggcgc gtggtcggtg gcgacgcagt cgatggtgcc gtcggccagg ccctcgcgca
     4441 gcgcctgcac gtcctcggcc gtgcgcagcg gcgggttgac cttgtagacc gggtcgtagc
     4501 tctcggcgag gtcgtcggtg agcagcaggt ggtgcggggt gacctcggcg gtgacgtcgc
     4561 agccgcggct cttggcccag cgcaggatct gcaccgagcc cttggtggag acgtggcaga
     4621 cgtgcagccg ggagccgacg tgctcggtga gcaggcagtc gcgggcgatg accgcctcct
     4681 cggccacggc cggccagccg gccaggccca ggcggtcgga gaccacgccc tcgttcatct
     4741 gggcgttctc ggtcagccgg ggctcctggg cgtgctgggc gaccacgccg tcgaacgcct
     4801 tgacgtactc cagggcgcgg cgcatcagca gcgcgtcgga gacgcagtgg ccgtcgtcgg
     4861 agaagacgcg caccccggcg gcggagtcgg ccatggcgcc cagttccgcc agttgggcgc
     4921 ctgccaggtc gcgggtgacc gcgccgacgg gttggacgtc gcagcggccc gactcgcgcc
     4981 ccagccgcca gacctgctcg acgacgccgg cggtgtcggc gacggggtcg gtgttggcca
     5041 tggcgtgcac ggcggtgtag ccgccggcgg ccgcggcgcg ggtgccgctg gcgacggtct
     5101 cggcgtcctc gcggccgggt tcgcgcaggt gggtgtgcag gtcgaccagg ccgggcaggg
     5161 cgatgagccc gtcggcctcg accacggcgg cgccggcggc gccgagcccg gtgccgatct
     5221 cggcgatcgc gccgtcgcgg atgaggatgt cggccgggtc tcccccggcg atgcgggcgc
     5281 cgcggatcag gtaggcggcg ctgctgtggg tcatgtctgt catcgcttct gtgtcagtcg
     5341 ttgcggtgcg gcgcggcggt gcggcggcgc ccccggcggg tcgggggccg agccgcggct
     5401 aggagccgcc caggagcagg tagagcaccg ccatgcgcac gctgacgccg ttggcgacct
     5461 gctcgttgac ggtgctgcgg gcggagtcgg cgacctcggc ggagatctcc atgccgcgga
     5521 ccatgggccc ggggtgcatg acgatggcgt cgtcctgcat ccgcgcgaag cgctcgccgt
     5581 cgagcccgta gcggcggctg tactcgcgcg cggtgggaaa gaacgcgtcg tgcatgcgct
     5641 cggcctgcac ccgcagcagc atgaccacgt cgctcttggg cagcacggcg tcgaggtcgt
     5701 aggagaccga gcagggccag gtgtgcaccg agaccgggac cagggtcggc ggcgcgacca
     5761 gggtgacctc ggcccccagg gtgtgcagca gcagcacgtt ggacctggcg acccggctgt
     5821 gcagcacgtc gcccacgatg gccacgcgca ggccgtcgag ccggcccagg cgctcgcgca
     5881 tggtgtagac gtccagcagc gcctgcgtgg ggtgctcgtg ggtgccgtcg ccggcgttga
     5941 gcaccgagcc gtcgacccac tcggcgagcc ggtgggcggc ccccgaggcg ctgtggcgca
     6001 cgaccacgcc gtcggcaccc atggcctgca gcgtcagcgc ggtgtccttg aggctctcgc
     6061 ccttggacac gctggagccc ttggcggaga agttgacgac gtcggccgag aggcgcttgg
     6121 cggcgagttc gaaggaggtg cgcgtacggg tggagtcctc gtagaagagg ttgaccacgg
     6181 tgcggccgcg cagggtgggc agcttcttca ccgagcggcc gctgacctgg gcgagctcgg
     6241 cggcggtgtc gagcaccagc agggcctcgt cgcgggtgag gtcgccggcg gagagcaggt
     6301 ggcgcatcag gcctcctccg ccgcggggct ctccgcgccg gcgcgcggct tggccgggcc
     6361 gagcaggacg gcgtcggtgc cgtcgtactc gctcagctgc acggtgacgg tctcgcgcag
     6421 ggaggtgggc aggttcttgc ccacgtagtc ggcccggatc ggcagctcgc ggtggccgcg
     6481 gtcgacgagg atggccagct gcaccgcgcg ggggcggccg atgtcgttga gggcgtcgag
     6541 cgcggcgcgc accgtgcggc cggagaagag cacgtcgtcg acgaggacga cgaggcggcc
     6601 gtcgaccccc tcgggcggga tctcggtgcg ccccagggcg cgggccgggg ccagccgcag
     6661 gtcgtcgcgg tacatggtga tgtcgagtga gccctggggg acggtgcggc cctcgacgcg
     6721 ctcgatgcgc tcggccaggc gcgcggccag cggtacgccg cgggagggga tgcccagcag
     6781 ggtgacgtcg gcgccgccct tggtgcgctc caggacctcg tgggcgatgc gggtgagcgc
     6841 ccgctgcatc tcgggaccgt ccaggaccgt ccgcgcgggc tcggggacgc gttcggcggc
     6901 ggagccgccc ggcgcatccg aatcacgttc ggcgcgcgat tgcgcacaca cagtagtgac
     6961 ccccttccct gcctcacagg acaggccgtt aaaggatgtc gatcggcttc acgctaccag
     7021 cgggaagcgg gcgcgccggt cggcgcgaac agcgaaaccc ggaggaatgt gactctcgcc
     7081 acaaccgaag ttattgacat attgccccat agatcggtga aaagggcgca acgccgggcc
     7141 cgcttctcgg acagagcagc gaaaaccctg cgccatcggg ctttccgcca ccgacggcga
     7201 ggcgggatgt ccgcatcggt ccggaaatga gagccctctc acttacacac ggtttggcca
     7261 ctgaatcgtc gcttttccac ccaacggctt gacctggcaa ccgaacagcc ctaccgtcac
     7321 tgtccgtaac caatctcggg cggggccgct ccgtccgggc cctgcggcag gagcccaccg
     7381 ggcgccttcg gccgggcgcg gtcacccacg ggcgacttcg gggccccacc gcccacacca
     7441 gccaccttca cggccgggga gcgacgaaga agatgccatc cgaatacgcc aagtccctcg
     7501 gtgcgcggct gcgcgccatc cgcacccagc aagggctttc cctgcacgga gtggaggaga
     7561 agtcccacgg ccgctggaag gccgtcgtcg tgggctccta cgagcgcggc gaccgcgctg
     7621 tgaccgtcca gaagctcgcc gaactggccg acttctacgg cgtccccatg tcggaactgc
     7681 tgcccggcgg cgcggcgccc gcaccgctgg ggcctacgcc caagctggtc atcgacctgg
     7741 agcgcatgca gcagctgccg caggagaagg ccggtccgct cgcccgctac gtggccacca
     7801 tccagagcca gcgcggcgac tacaacgggc gagtgctgtc catccgccag gaggacctgc
     7861 gctcgctggc ggtcatctac gaccgctcgc ccggcgacct gaccgaggag ctgatcaact
     7921 ggggcgtcct cgatcccgaa gcgcgccgcg cggtcgacgc cttctagcgc cgggagaccc
     7981 ttcgtcagcc cccttgcacc ggggccgcac agcggtgccg ccgctgcgcc gcgccggtgc
     8041 cgcacggacc ggccctgccc ggcgccccgc cggcccgggc gcggccccga gcccggacga
     8101 cgacggccac gtcccacgcg gatccccccg cgggacgtgg ccgttcgcag tgcgcgggcg
     8161 ccgcgccgga cgcggcgccc ggccccggac gagcgcgcct gaacgcccgg ggaaggccgc
     8221 ggccgggcaa gaggcttccc ctccccccgc ccggccgctt cccgcactcg cgtgtccgcg
     8281 cggagcgcgg cggcgagcgc gagtcatcga cgtactctcg gacacccccg tctctcggac
     8341 accggggatt cgaacgtgag tacgaacaga accagttaag cgtaccccgg ccgccctcgt
     8401 caacagctcc gcgcgcaagc gcccgtcgca taccgtggcc ctgtgcagac caccgacatc
     8461 gagctgtggg aactggccgc tccggccttc ctgcacgccc tgcccgcact gctggagatc
     8521 tacaccgcgg cgatggatcc gcccccggag cagatccccg ggcgccactc catcatgcgc
     8581 gagcacgccc gccagccgcg gttccgctcg gtggtcgccc tgccccggtc gggcacgggc
     8641 gccgccgggt tcgcctacgg cttccacggc tccggggggc agtggtggca cgacgtcgtc
     8701 acggccgagc tgcgcgagcg cgatcccggc gccgaccggc gctggttcgc cgactccttc
     8761 gaggtggccg agctgcacgt gcatcccgcc cagcaggggc gcggcatcgg ccgcggactg
     8821 ctggaagcgg tgacggcggc gcgcaaagag cgcaccgccg tcctgtcgac cccgaccggc
     8881 cggacggccg cccggggcct gtaccgctca tgcggtttcg tcgacgttct accggagttc
     8941 cacttccccg gcagccctca ccggcccttc accatcatgg ccgcgcccct gccattgccg
     9001 ggaggcggtc agcggcgacc tgctcgtaga tctcccgtgt ggcagtggac tggttgaagg
     9061 tgatgaagtg gatgccgggg gcgccctcgt ccagcagccg ctcgcacatg cgctgcgcct
     9121 gctcgattcc cagcttgcgc accgcctcgg gatcgtcctt gaccttgtcg aactccgcgg
     9181 cgaggtggcg cgggaagggc gcgccggaca gctgctcgga catgtcgatg gtggagtact
     9241 tcaccaccgg catgatctcg gggatgatcg gagtttcgca gcccgcggcc gccacgcggt
     9301 cgcgcaggcg caggtagtcc tcggggtcga agaacatctg ggtgacggcg tagtcggcgc
     9361 ccgcacggca cttctggacg aggtacttcg tgtcggactc gatgtcgggc gagcgggggt
     9421 gcttgtaggg gaaggcggcg acgccgacgc tgaagtcgcc ggtctccttg agcagccgga
     9481 ccaggtcctc ggcgtactcc agtccctcgg ggtgcttgac ccactcgccc agcggatcgc
     9541 ccggggggtc cccgcgcagc gcgaggaagt tgcccacccc cacgccggcg aagcgcccga
     9601 tgaggtggcg cagttcgcgc acggagtggt tcacggcggt catgtgggcg acggggagca
     9661 gggtggtgtc tgtggcgacc tgctcggtga tctcgacggt gagatcacgg gtaccgccgc
     9721 cggcgccgta ggtgaccgag atgaacgacg gctgcagcgc ctcgatctgg cggatgaccc
     9781 gccagagctt gcgcagccct tcgtccgtct tcggggggaa gaactcgaag gagaatgtcg
     9841 gttcgccggt cttgagcagt tcgcggatgt cgcgcggccg cggcgctgcg gccggcgcgc
     9901 tcccgttgcg tgtcgttgac ccaaccatac ggtccacctt aggcgactcc ctgtccagcg
     9961 ccgggagggt gggtgcccac tacccgataa cctgcagccc atgaccttct ccgcctcctc
    10021 cccgatctcc ttcgtgcgca cggccgtcga cggcgagatc gccggcttcg tcgcccgccg
    10081 gcgcgcccag ctgctggaga tcggctccga gctggcgccg atcgtcgacg cgctggaggc
    10141 catgctcgcc ggcggcaagc ggctgcgccc ggcgttctgc tactggggct ggcgcggcgc
    10201 gggcggcgac gacgtccccg gcatccacgc cgccgcggcc tcgctggagt tcctgcaggc
    10261 ctgcgcgctc atccacgacg acgtcatcga caacagcgac acccgccgcg gcctgcccgc
    10321 cacccacaag cgcctggagg cgctgcacga gcgctcgggc tggagcgggt cggccgaggc
    10381 gttcggccgc ggcgcggcga tcctcatcgg cgatctgtgc ctggcctgga gcgaggacct
    10441 ctaccagtcc agcgggctgg gtctggaggc gctgagagcc gggcgcacgc ccttcgacgc
    10501 catgcgcacc gaggtgatgg ccggccagta cctggacatg ctggagcagg tgcgcgaggg
    10561 cggcggagtc gaggcgacgc tgcgggtcat gcactacaag gccgccaagt acaccgtcga
    10621 gcggccgctg cacctggggg cggcgctggc gggccgctac ggcgacctcg cccccgtcta
    10681 caccgcctac ggcctgccgc tgggggtggc cttccagctg cgcgacgaca tcctgggggt
    10741 cttcggcgac cccgagcaga ccggcaagcc ggcgggcgac gacctgcgcg agggcaagcg
    10801 cacgctgatc gtggccgaga ctttggagcg cgccggcgcc gccgaccgcg cggagttcct
    10861 gcgccgcctg ggcgaccccg ccctgggcgc cgagcaggtg gagtggatgc gcggcgtggc
    10921 cgaggactgc ggcgccctgg cggcctgcga gcggcgcatc gacgactacg ccgcccaggc
    10981 caccgcggcg ctggagaccg gccgcctcga cgacacggcc cgctcccccc tggccgacct
    11041 cgtcgtggcc gccaccgccc gcaagcactg agcaccggcg ctgctctcgg ccggccggcg
    11101 cgcgcctccc ccgcgcggcg gatgcggatc gtgcccgcgg cggattccgc cggtgcccga
    11161 acctggggca ggctggggta cgagcccgat tcgcggcgct tcgccccggt ctgaaaggca
    11221 ccaccgtgga tcccacaccg gcccccgcac gcgggcccgt ccgccccggc gagcgcgccc
    11281 cggggcccga tctcgcccgc gggttcatgc tgctgctgat cgcgctggcc aacacgccct
    11341 ggtacctcta caccgccgac caggcggcca ccggcgccca tcccgcggac gggtcggcgg
    11401 ccgaccgcgt cgtccagttc gccatgctca ccgcggtgga cgggcgggtg tacccgatgt
    11461 tcgcgtgcct gttcggctac gggctgatcc gcatctacga ccgccagcgc gacgccggcg
    11521 cctcggcgcg cgaggccgcc gcggtggtgc gccggcgcaa cctgtggctg ctggtgttcg
    11581 ggttcgccca tgcggcgctg ctgttcttcg gcgacatcct tggggcctac ggcctgatcg
    11641 ggctggtggc gggccggctg ctgctgcgcc gcggcgaggc ggcgatgcgg gtgaccgcct
    11701 cggtgctgat cggtctggtg atggcgctgt ggctgatgtg catcctgggc gcggtggtgg
    11761 ccgcctcggc cccggccgtg cgcggcgggc aggcggccat ggcgattccc ggcttcctgc
    11821 ggtcctcctt cagcgaaccc ggctacgtcg acgccatggc cgaccggatc gccgggtggg
    11881 cgctcatggc gccgctgcag gcgctgtccc tggtgctgcc cgccatggtg gtgctgggca
    11941 tgctgatcgg ccgccgccgc gtgctggagc ggaccgaccg gtaccgcggc gtgctgatct
    12001 ggaccgccgc gggcgggatc ggcctggcct gggcgtccgg gctgcccgag gcgctggtgc
    12061 acgtgggcct ggtcgaggtc tccggcccgg tcgcctccgc cctgggcggc gtccggcagc
    12121 tgagcggggt gttcggcggc gccggctacg tcgccctgtt cgggctggtc ggcggcgcgc
    12181 tcgcgcgccg ggcgcggatg ggcgcgggtg cggcggccgt cgcggcggtc ggcaagcggt
    12241 ccctgtcgtg ctacctggcc cagtcggtga tctgcgcgcc gctgctggcg gcctggggcc
    12301 tggggctggg cgcgcacctg ggcagcgcca cgatggccct cttcgccgcc ggcgtgtggc
    12361 tggtgacgct cgccggcgcc tacgcgctgg agcgggccgg ccggcgcgga ccggccgagg
    12421 tgctgctgcg ccggctgagc taccggtcgg cggccgggcg cggcggcgag ggcagcgggg
    12481 cggaggcgcc ggcccgctga aggccgcgcg cccgggccgg ccccgccccc gcgcgggtca
    12541 gccgcggacc tcgacgacct tgaggtcacc cgcggactgc ttgctgcgca gggtcttctt
    12601 gtcgaacttg ccgacgctgg tcttgggcac ctcgtcgacg aaggcccaga actcgggcag
    12661 ctgccagcgc gccagccggt cggccaggaa cgcgcgcagc tccgcggcct cggcggtggc
    12721 gccctccttg aggacgacgg cgaccatggg ccgctcgtcc cacttgggat cgggcacggc
    12781 cacgacggcg gcctcggcga ccgccgggtg ggccatgacg gcgttctcca gctcgaccga
    12841 ggagatccac tcgccgccgg acttgatgac gtccttggcg cggtcggtca ggcgcaggaa
    12901 gccgtcgggg gtgagggtgc cgacgtcgcc ggtgcgcagc cagccgtcgt ggaacttctc
    12961 cgggtcctcg tcgccgtagt aggagccggt cacccagggg ccgcgcacct ccagctcgcc
    13021 cacgctggtt ccgtcgtggg gcaccggctc gccgccgggg ccgatgagcc gcccctgcac
    13081 gggcgccagc agccggccct ggctcaggcg gtaggcccag cgctcgtcgc cggaggatcc
    13141 ggccggcggg cgggcgacgc tgcccaccgg ggaggtctcg gtcatgcccc aggcgtgcag
    13201 cagcgggatg ccgtagcgct cctcgaagcg ctgcatcagc gcgggcgggc aggccgagcc
    13261 gccgaccacg acgctgtgca gcgaggagag gtcgcgaggc gacgactcca gctcctccag
    13321 caggccctgc cagatggtgg gcacggcggc ggcgacggtg gggcgttcgg cctcgatcat
    13381 gtcggcgatg ggtcccggct gcaggaagcg gtcgggcagc agcagcgagg cgccgacgag
    13441 cagcgcggag tagggcagtc cccagctcat cgcgtggaac atcggcacga cggccagcgc
    13501 ggtgtcgctc tgggcgaggg cctcgccgtc ggtcatgcac ccctgcatcg agtgcaggta
    13561 gatggaccgg tggctgtagg cgacgccctt gggcgcgccg gtggtgccgg aggtgtagca
    13621 catggcggcg gcgtcgcgct cgtcggtctc gggccagtcg aaggtctcgg gccggccggc
    13681 gatgaggtcc tcgtaggcgt gcacggcgac cccctcggcc gccaggtcgc cggggtctcc
    13741 cccggcgacg atcacgtggc gcacggtgcg cagccgcggc aggatcggcg cgaacagcgg
    13801 cagcagggag gcgtcgacga tgacggcgtg gtcctcggcg tggtcggcga tgtaggcgac
    13861 ctggtcggcg tgcagccgga tgttgagggt gtgcagcacg gcgcccatgg ccggcacggc
    13921 gaggtaggcc tccaggtgct cctggttgtt ccactggaag gtggccacgc gctggtcgcc
    13981 ggtgaccccg aggtcgcgca gggcgtgggc gagccgggcg gcgcgggcgc cgacctcgcc
    14041 gagggtggcg cggcggggtt cgccgccggt ccaggtggtg atgcgggccc ggctgtgcac
    14101 cgagacgccg tagcggacga ggttgccgac ggacagcggg acgtcctgca tggtgctgcg
    14161 cattcgccct cacccttcgc gctgatcgga cgtggcgtgt tccactgacg ctagagggct
    14221 gaggatgccg cgggaaagag ggcggggggc atcgttaccc gacactgtca ggcgggtggc
    14281 ggccccgacc ggcgcggtcg gcgcagccgg ctcagtccgc ggcggcgagg cggcgctgga
    14341 actccgcagc ggcggcacgc gggtcgtcgg cccgggtgat ggcgcgcacg accacgacgc
    14401 gccgggcgcc ggcggcgagc acccggtcga ggttggccag gtcgatgccg ccgatggcga
    14461 accaggggcg ctcgggcgcc atcgcggccg tgcgctccac cagctccagt ccggcggccg
    14521 ggcggcccgg cttggtgggg gtggtccagg tggggcccac gcagaagtag tcgacgccct
    14581 cctcctcggc ggaggccgcg gccatcgcgg cgtcgctgtt ggagcggccg atcagcggcc
    14641 cggggccgac cacggagcgg gcgtggcgca ccgggaggtc gttctggccc aggtgcagca
    14701 cgtcggcgcc ggccgccagc gcgatgtcgg cgcggtcgtt gaccgacatc agggcgccgt
    14761 gccgctcgca ggcggcccgc acggtctcca gggcggcgag ctcctggcgc gcctccaggg
    14821 acttgtcgcg cagctgcacg atgtcgacgc cgccggccag cgcggcgtcg aggaactcgg
    14881 ccaggtcgcc ctgctcggcg cgggcgtcgg tgcacaggta caggcgcgcc cggtccaggc
    14941 gctctcgcaa gctcgcgttc acggggccag ggtagccgcc ggggtccggg cgcctgcgag
    15001 cgcaccgggc atcggacgcg cccgccgccc gggccggccg ctcagaaggc catggcctgg
    15061 gcgcggcggc ggacctccgt gccgcggttc tccgagagcg cctggatggg tgcccccgga
    15121 agcgtgtcgt cgggggtgaa catccactgc agcgcctcgt cggtgctgaa cccggagtcg
    15181 gccaggacgg tgagcgtgcc gggcaggccc ttgacgatgt cgccgccgga gatgaaggcg
    15241 gccgggatgc acagttcgcc gtcgcgccgc acgcccagca gcttgtggtc ggcgatgaac
    15301 tgcttgatcc ggttcgggct gacgttgagc gccttggccg cgtccttcag cgtcatccat
    15361 tcgccgacga gggcgtcggt gtcgcggtcg ttctcgttca cgctgccaat gtgccacacg
    15421 cgcccccgcg ccaaacgccc gcgcggcgcc gtatcgctct aggcgtactg cccgagcgct
    15481 cgcgggatcg gggtcataga atggtaggtg gacgagaaca ccccgcggga gccgggtcgg
    15541 aacccggctg agagggaggc tggcagtctc cgaccgcatg aacctgatcc gggtcatacc
    15601 ggcgaaggaa gtggcagcag acccgtgcgc gcaaacccct cttcgcaatc gccgaccgac
    15661 gtggtcgtgg tcggcgccgg gctcatcggc ctggtcaccg cctggcgggc cgcctgcgcc
    15721 gggctgagcg tcaccgtggt ggccgagcac ctcgacggcg ccgcctccac cgtggccgcg
    15781 ggcatgctca cccccgcgac cgaggcgtcc ttcggcgagg aggcgctgat gcgcttcggc
    15841 atcctctccc gcgaccgcta tcccgccttc gtggccgaac tggaggagga gagcggggtc
    15901 tcggcgggct accgcgccga gggcaccctc caggtcgcct tcgactccga cgacatggcg
    15961 cggctgggcc acctcagcga actgcgggcg cggctggggc tgaccaccga gcggctcacc
    16021 ggccgcgagt gccgcaggct ggaaccgatg ctcgcgccgt cggtgcgcgg cggctacctg
    16081 gccgccgagg accattcggt ggacccgcgc gcgctgctgg gggcgctgcg ggccgccgcc
    16141 gagcgccgcg gggccgtggg cgtgcgcgac cgggtccgcc ggctcgtcgt cgaggacggc
    16201 cgcgcccgcg gcgtggtgct cgactccggc ggcgagatca gcgccgggca ggtggtgctg
    16261 gccgcggggg tggccacccc ggccgtcgag ggggttcccg agggcgtggt tccgccgctg
    16321 cgcccggtca agggccagct gctgcgcctg cgcatggccg aaggcgagcc gcccatcgtc
    16381 gcccgcaccg tgcggggcct ggtcaagggc tcccccgtct acctcgtgcc gcgcggcacc
    16441 ggcgagatcg tgctcggcgc gacccaggag gagcagggat tcgacaccag gctgacggcc
    16501 ggcgggctgt gggaggtgct gcgcgacgcc cacgagctgg tgcccggcgt cagcgaactg
    16561 gaggtcgccg agacctgcgt ggggctgcgg cccggctccc ccgacaacga gccgctgctg
    16621 ggacccaccg cggttcccgg cctgcacctg gccgccggcc acttccggca cggggtgctg
    16681 ttcacaccgg ccaccggcga cgccatggcc gaggcactga ccaccggcgc gctccccgac
    16741 tacgcgcgcc ggttcgccgc cacccgcgtc gcggaccgga tcccggccgg cgcagcgggc
    16801 ggcggcccca tcgagggagg cgagcaggac cagtggacgt gatcatcaac ggcgagcgcc
    16861 gcgcggtctc accccggacc accgtggagg aggtcgtgcg gtcgctgacg cgggagcccg
    16921 gcggcgtggc cgtcgcgctc aacgacgagg tcgtgcccaa ggccggctgg gccaccaccg
    16981 aggtcggcga gaacgaccgc atcgacgtgc tcaccgcggt ccaaggaggc tgacatgaca
    17041 tccacgcaca gcccggcgct gcccgactcc cccgccgaac cggccggggc gccccgtcag
    17101 gccgccggcg gcgacccgct ggtcatcgcc gggcgctcgt tcacctcccg gctgatcacc
    17161 ggcaccggcg gcgccccgtc gctgcgcatc ctggaggacg cgctggtcgc ctcgggcacc
    17221 gagctgacca ccgtcgcgct gcgccgcgtc tcccccgacg ccgagggctc ggtgtgggac
    17281 ctgctgcgcc gcaacggaat ccggccgctg cccaacaccg cgggctgctt caccgcgggc
    17341 gacgcgctgc gcaccgcccg cctggcccgc gaggcgctgg agaccgactg gatcaagctg
    17401 gaggtcgtcg ccgacgaccg caccctgctg cccgaccccg tcgaactgct ggacgccgcc
    17461 gagcgcctcg tcgacgaggg cttcaccgtc ctgccctaca ccaacgacga cccggtcctg
    17521 gcccgccgcc tggagcaggt gggctgcgcc gcggtcatgc cgctgggcgc gccgatcggc
    17581 tcgggcctgg gcatccgcaa cccgcacaac atcgagctga tcgtggagca ggcgggcgtc
    17641 ccggtggtca tcgacgccgg catcggcacc gccagcgagg ccgcgctggc catggagctg
    17701 gggtgtgacg cggtgatgct ggccacggcg gtcacccgcg cgcaggaccc ggtgctgatg
    17761 gcccgcgcca tgcgcgacgc cgtcgccgcc ggccgcgccg cccgccgcgc cggccgcatc
    17821 ccggtgcggc gctacgccca ggcgtcctcc ccggcggtgg actgagtccc gttccgcggg
    17881 ggcccgtcgc gccccgggcg ggatgcgccc gggtgcgcag gacaggctcc aggccccgca
    17941 cccgggcggc cccggcgacc ggcccgggcg gcgggcccgg ctccgcgcgg gcggcgggcc
    18001 cggctccgcg cgggcggcgg cgatccccgg gcgcgcgtat ccggcgtttc gtcacccagg
    18061 gtgatcgaac cgttgcgcga agcctggtgg accggggttg gcaacatcac cccggaagcc
    18121 gacaaacccc caggccagcg ggttacgcgc cggtagtcta cgcccccggg cggccgtcgg
    18181 cgcagtcgcg aagcgttgga cgccttacac tcccgtgtgt ggacatgacg actgccgacc
    18241 ctctggtggg cacgacactc gatcagcgct accacgtcga ggcacgggtg gccagcggcg
    18301 gcatggccac ggtctatgtc gcgcacgacc ggcggctgga ccgccgcctg gcgtgcaagg
    18361 tcatgcaccc ctcgctggcc caggaccctt ccttcgtgcg ccggttcatc aacgaggcgc
    18421 actcggtggc caagctctcc caccccaacg tcgtacaggt ctacgaccag ggcaccgacc
    18481 agggccacgt ctacctggcc atggagtacg tgcccggcca gaccctgcgc gacatgctca
    18541 acgcccgcgg ccggctcgcc cccgccgacg cgctggaggt catctcgccg gtgctggccg
    18601 ctctgggcgc cgcccaccag gccgggctgg tccaccgcga cgtcaagccc gagaacgtgc
    18661 tgctcaccga ggacgggcgc gtcaaggtcg ccgacttcgg cctggcgcgc gcggtcgagt
    18721 ccgcccagca gggcaccacc aagaccggca cggtcatggg taccgccgcc tacctggctc
    18781 ccgagcagat cgagcgcggc gccgccgacg cgcgcaccga cgtctacgct gccgggatca
    18841 tgctgtacga gctgctgacc ggttcgcagc cgcacaccgg cgacaccccc atctccatcg
    18901 cctaccagca tgtcaacgag gacgtgccgc ggccctcgcg cgccgtcccc ggcctgccgc
    18961 cgcaggtcga cacgctggtc acccgcgcca ccgagcgcga cccgcgctac cgtcccggcg
    19021 acgccgggca gtacctcgcg ctggtgctta acgtgaagtc ggcgctgccc gccggcgccg
    19081 cggcgggccc cactgccggg ccgcaggcga tcggcgcggc gcccgcgggc ggcgacggca
    19141 acgacaccct ggtcgtcgag accggcgggc tgcccgacgc cgcaccggtg gagcccgact
    19201 acggcgaccg cggccggaac cggcggctgg acctggacta ccgcagcctc ccggtgatcg
    19261 tggtcgccgg tgtgctcgcg gtgctgatgc tggggttcgg ctggtggttc ctggtgggcc
    19321 gctacgagcc cgtgcccgac gtggtcggca tgcaccagca ggacgcccgc gcggtgctgg
    19381 gcgacatccc ggtgcaggtg gaggtcggcg acaagcgcgt ctactcccag gaggaccccg
    19441 gatcggtggc caaggtcgaa cccgccgtcg gcgagcgcat cctgcccgag gacacggtga
    19501 ccgtgttcct gtccaagggc ccccagaccg tcgagatgcc cgacctggtg ggccagagcg
    19561 cccaggacgc ccgcgcggcg ctggaggacg acggcttcgc cgagatcgtc gaggaggaga
    19621 ccacctccca ggaccacccc gcgggaacgg tgatcagcac cgaccccgag ccgggcgccg
    19681 acgccgaccg cgaggccccg gtcacgctca ccgtcagcga gggcttcgag gtccccgacg
    19741 tcgaggggct gcagcaggac caggcgcaga gcacgctgca ggaggcgggg ctgcaggtct
    19801 cggtcaccga gcagcccagc gaggacgtgc ccgagggcga ggtcatctcc caggaccccg
    19861 ctgcgggcgg caccgtcagc tccggcgaca gcgtcacgat cacggtctcc tcgggccccg
    19921 aggagatcga gatccccgac gtgaccgggt ggaaggtcga cgacgccaag aagcacctgg
    19981 aggagctggg cttcaaggta aaggtctccc gcctgttcgg gggcgaccgc gtcacccgct
    20041 acagcccgca gggctcggcg accgaaggca ccgagatcga gctgatcgcc agcccgttcg
    20101 cgccccaggg cggcgacgac ggcggtggcg gcggccgtcc gggcaacggg aacggcaacg
    20161 gcaacgacga ctgatcggcc ggcgccgcgc ccggtccgct agggtcgccc catggcagag
    20221 cagcccccgg ccggtggatc ggccgcagcg ccgccgcagc ggcccatccg cgtgatggtc
    20281 gtcgacgacc acccgatgtg gcgcgacgcc gtggcgcgcg acctcgccga ggccggcctg
    20341 gaggtggtgg ccacggcggg cgacggcgcc aaggcggtgc gcgtggcccc ggcggcccgg
    20401 cccacggtgg cggtcctgga cctgcagctg cccgacatcg ggggcgtgga ggtcacccgc
    20461 cgactgctgg agggcgccga tccgccgcgc gtgctggtgc tctcggccag cggcgagcag
    20521 accgacgtcc tggaggcggt caaggccggg gcgaccggtt acctggtcaa gtcggccggg
    20581 cgcgaggagc tgctggaggc ggtgcgccgg gtccacgacg gcgaggccgt ctacaccccc
    20641 gggctggccg ggctggtgct gggcgagtac cggcgcatgg ccgccgagcc gcggccgggt
    20701 cgcgacccgg ccgcgccgtc gctgacccct cgcgagaccg aggtgctgcg gctggtggcc
    20761 aaggggctgg gctacaagca gatcgccgag cgcctgacgc tgtcccaccg caccgtgcag
    20821 aaccacgtgc agaacacgct gagcaagctg cacctgcaca accgggtgga gctggcccgc
    20881 tacgccatcg accggggact cgacggcgac gagtgaggcg ggggcgccgg ggcccgcgcc
    20941 cccgcactcc gccgccgcct cggcggctgc cgaggcggcg gcgggggcga ccgggctcag
    21001 cccagctcgg cccagccctt ggagcgctcc acggcctcgc gccagcgcgt gtgggcggcg
    21061 tcgtcgcggg c
//
